Publications

improvement of identification of capnocytophaga canimorsus by matrix-assisted laser desorption ionization-time of flight mass spectrometry using enriched database.	capnocytophaga canimorsus and capnocytophaga cynodegmi can be transmitted from dogs or cats and cause serious human infections. we aimed to evaluate the ability of matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) to identify these two capnocytophaga species. ninety-four c. canimorsus and 10 c. cynodegmi isolates identified by 16s rrna gene sequencing were analyzed. using the maldi biotyper database, correct identification was achieved for only 16 of 94 ...	2016	26508105
capnocytophaga canimorsus meningitis diagnosed by 16s rrna pcr.	capnocytophaga canimorsus is a common gram-negative anaerobic bacterium from the oral flora of dogs, typically transmitted to humans by dog bites. we report a case of c. canimorsus meningitis where there was (on presentation) no apparent predisposing risk factor and in whom we used 16s rrna pcr gene sequencing to identify the pathogen quickly and to switch to appropriate antibiotic therapy. physicians should be aware of potential c. canimorsus meningitis if conventional cerebrospinal fluid bacte ...	2016	26608220
[epidemiology, microbiology and diagnostics of dog and cat bites related infections].	animal bites represent a significant global health problem and account for approximately 1-2% of all visits to the emergency department. the vast majority of animal bite injuries are inflicted by dogs (80-90%,) and cats (5-15%). the most common complication following an animal bite is a wound infection, which tends to be polymicrobial and include both aerobic and anaerobic bacteria mainly of oropharyngeal origin. the likelihood of a cat bite becoming infected is double of that of a dog bite. pas ...	2015	26608484
[severe sepsis after dog bite caused by capnocytophaga canimorsus].	we describe a case of a life-threatening septicemia resulting from a previous dog bite wound. the isolated bacterium was capnocytophaga canimorsus, a slow-growing gram-negative bacillus commonly found in dog saliva. known risk factors for invasive c. canimorsus infections are alcohol abuse, cigarette smoking, splenectomy or other forms of immunosuppression. any clinician seeing patients with a history of a dog bite should consider this pathogen as a causative agent and take detailed history rega ...	2015	26608488
modification of the 1-phosphate group during biosynthesis of capnocytophaga canimorsus lipid a.	capnocytophaga canimorsus, a commensal bacterium of dog's mouth flora causing severe infections in humans after dog bites or scratches, has a lipopolysaccharide (lps) (endotoxin) with low-inflammatory lipid a. in particular, it contains a phosphoethanolamine (p-etn) instead of a free phosphate group at the c-1 position of the lipid a backbone, usually present in highly toxic enterobacterial gram-negative lipid a. here we show that the c. canimorsus genome comprises a single operon encoding a lip ...	2016	26644381
correction: the n-glycan glycoprotein deglycosylation complex (gpd) from capnocytophaga canimorsus deglycosylates human igg.		2015	26671777
capnocytophaga canimorsus meningitis: three cases and a review of the literature.	bacterial meningitis is a disease with a high morbidity and mortality. it may be caused by the zoonotic pathogen capnocytophaga canimorsus, which is part of the commensal oral flora in dogs and cats. we report three cases of c. canimorsus meningitis in a nationwide cohort study of bacterial meningitis patients and performed a review of the literature. three episodes of c. canimorsus meningitis were identified in three patients included in a nationwide cohort study from 2006 through 2014. the cal ...	2016	26693951
capnocytophaga canimorsus sepsis following a minor dog bite to the finger: case report.	capnocytophaga canimorsus is a gram-negative bacillus present in the oral cavities of 22% to 74% of healthy dogs. capnocytophaga canimorsus has unique virulence factors that enable it to evade the human immune system and cause life-threatening sepsis following a dog bite. we report a previously well 68-year-old woman who presented with septic shock and multiorgan failure following a seemingly minor dog bite to the finger. the patient required intensive care treatment, intravenous antibiotic ther ...	2016	26710739
mycotic aneurysm following a dog bite: the value of the clinical history and molecular diagnostics.	a 63-year-old caucasian taxi driver presented with a 3-week history of malaise, night sweats, 7 kg weight loss, generalized arthralgia, and persistent mid-lower abdominal pain. blood inflammatory markers were raised, and a computed tomography scan demonstrated an irregular degeneration of the infrarenal aorta, with a differential diagnosis including aortic infection. an urgent type iv thoracoabdominal aneurysm repair was performed with a rifampicin-soaked aortic tube graft during an open procedu ...	2016	26802291
urticarial exanthem associated with capnocytophaga canimorsus bacteremia after a dog bite.		2016	27051842
capnocytophaga canimorsus bacteremia: clinical features and outcomes from a helsinki icu cohort.	capnocytophaga canimorsus is a gram-negative rod capable of causing severe sepsis or septic shock. we studied the characteristics of patients with c. canimorsus bacteremia treated in intensive care unit (icu).	2016	27251795
lick of death: capnocytophaga canimorsus is an important cause of sepsis in the elderly.	a 70-year-old caucasian woman was treated for capnocytophaga canimorsus septicaemia. the source of bacteraemia was very likely to be her household pet, an italian greyhound. the patient presented with a presumed complex partial seizure but deteriorated rapidly with sepsis and multiorgan dysfunction. neither scratch nor bite was established, although close petting including licks was reported. blood cultures grew gram-negative rods, identified by molecular techniques as c. canimorsus-a bacterium ...	2016	27364692
atypical hemolytic uremic syndrome associated with capnocytophaga canimorsus.		2017	27580961
[pets are a risk for asplenic patients: capnocytophaga canimorsus infection in an asplenic patient].	post-splenectomy sepsis is a serious condition with high mortality rates. we present a case of a 64-year-old patient with a medical history of splenectomy who was referred to the emergency department with a fever, shivers, and an altered mental state. the symptoms had started twelve hours before. upon arrival in the hospital the patient was tachypnoeic, hypotensive and febrile. blood cultures were taken and broad-spectrum antibiotics were started. he was directly admitted to the intensive care u ...	2016	27581861
diagnosis of capnocytophaga canimorsus sepsis by whole-genome next-generation sequencing.	we report the case of a 60-year-old man with septic shock due to capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. this technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis.	2016	27704003
identification of a new lipoprotein export signal in gram-negative bacteria.	bacteria of the phylum bacteroidetes, including commensal organisms and opportunistic pathogens, harbor abundant surface-exposed multiprotein membrane complexes (sus-like systems) involved in carbohydrate acquisition. these complexes have been mostly linked to commensalism, and in some instances, they have also been shown to play a role in pathogenesis. sus-like systems are mainly composed of lipoproteins anchored to the outer membrane and facing the external milieu. this lipoprotein localizatio ...	2016	27795390
capnocytophaga canimorsus – an underestimated danger after dog or cat bite – review of literature	capnocytophaga canimorsus is a gram-negative, capnophilic rod constituting normal bacterial flora of the oral cavity of dogs and cats. it is also considered to be an etiological factor of infections in human that may lead to multiple complications, i.a. sepsis, endocarditis and meningitis. c. canimorsus poses a serious threat, especially to patients with asplenia, cirrhosis or alcohol abuse. in most cases, infection occurs after a dog bite. isolation and identification of the bacteria from the b ...	2017	27837588
[dyspnea and skin rash in a 49-year-old male patient].	we report on the case of a 49-year-old man who presented with increasing dyspnea and a skin rash. the community-acquired pneumonia was initially treated with broad spectrum antibiotics. the patient's respiratory condition rapidly worsened and the clinical picture of waterhouse-friderichsen syndrome developed with disseminated intravasal coagulopathy and necrosis of the toes. an infection with capnocytophaga canimorsus, which had been caused by an initially unmentioned dog bite was confirmed. in ...	2017	27900398
evidence for a los and a capsular polysaccharide in capnocytophaga canimorsus.	capnocytophaga canimorsus is a dog's and cat's oral commensal which can cause fatal human infections upon bites or scratches. infections mainly start with flu-like symptoms but can rapidly evolve in fatal septicaemia with a mortality as high as 40%. here we present the discovery of a polysaccharide capsule (cps) at the surface of c. canimorsus 5 (cc5), a strain isolated from a fulminant septicaemia. we provide genetic and chemical data showing that this capsule is related to the lipooligosacchar ...	2016	27974829
inactivation of human coagulation factor x by a protease of the pathogen capnocytophaga canimorsus.	essentials capnocytophaga canimorsus causes severe dog bite related blood stream infections. we investigated if c. canimorsus contributes to bleeding abnormalities during infection. the c. canimorsus protease ccdpp7 causes factor x dysfunction by n-terminal cleavage. ccdpp7 inhibits coagulation in vivo, which could promote immune evasion and trigger hemorrhage.	2017	28029716
capnocytophaga canimorsus, a rare cause of bacterial meningitis.		2017	28034443
fatal infection caused by capnocytophaga canimorsus.		2017	28134123
"identification of virulent capnocytophaga canimorsus isolates by capsular typing".	capnocytophaga canimorsus is a dog oral commensal that causes rare but severe infections in humans. c. canimorsus was recently shown to be endowed with a capsular polysaccharide implicated in the resistance to the innate immune system of the host. here we developed the first c. canimorsus capsular serotyping scheme. we describe nine different serovars (a to i), which allowed to type 25/25 isolates from human infections but only 18/52 isolates from dog mouths, indicating that the repertoire of ca ...	2017	28381610
a small 'lick' will sink a great ship: fulminant septicaemia after dog saliva wound treatment in an asplenic patient.	capnocytophaga canimorsus is a bacterium transmitted through the saliva of dogs. an infection can cause severe sepsis with acral necrosis and is potentially fatal. here, we report the case of a 41-year-old man who was infected through a wound that was licked by his dog. he went into septic shock with disseminated intravascular coagulation and subsequently lost both lower legs, his nose and all the fingers on both hands.	2017	28425162
		2017	28443707
capnocytophaga canimorsus - an underestimated cause of periprosthetic joint infection?	periprosthetic joint infection (pji) is a major clinical problem in orthopedic surgery. capnocytophaga canimorsus (c. canimorsus) is an unusual and hardly detectable bacterium. a review of the literature indicates that c. canimorsus affects mainly immunocompromised patients. it has not been reported to cause periprosthetic joint infections in immunocompetent patients so far. this case report aims to raise awareness of c. canimorsus in orthopedic surgery with special regard to joint arthroplasty.	2017	28526202
[capnocytophaga canimorsus: a cause of multi-organ failure accompanied by livedo].		2017	28549666
cave canem: hbo₂ therapy efficacy on capnocytophaga canimorsus infections: a case series.	dog bites are a frequent injury, but the incidence and type of lesions vary across countries. although only few patients develop complications, the treatment of advanced injuries has a considerable medical, social and economic impact. a frequently isolated pathogen in dog bite wounds is capnocytophaga canimorsus, a bacterium that can cause sepsis or meningitis. hyperbaric oxygen (hbo₂) therapy has been shown to be useful in treating anaerobic infections, most likely because it creates an inhospi ...	2017	28777909
capnocytophaga canimorsus sepsis in a methotrexate-treated patient with rheumatoid arthritis.	capnocytophaga canimorsus is a gram-negative rod that can be transmitted primarily by dog bites. this life-threatening organism commonly causes sepsis in patients with splenectomy or alcoholism. a 53-year-old rheumatoid arthritis male treated with methotrexate (mtx) for 5 years was admitted for a 4-day history of fever and dyspnea. he had been bitten on a finger by the family dog 4 days before onset. laboratory tests revealed pancytopenia, acute renal failure, and evidence of disseminated intrav ...	2017	28831382