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influence of melatonin on pubertal development in male deer mice (peromyscus maniculatus).the role of melatonin in pubertal development was assessed in male deer mice (peromyscus maniculatus bairdii) exposed to photoperiodic and social stimuli. exogenous melatonin retarded puberty in males reared in a long photoperiod, but was without effect in males reared in short days. melatonin did not retard pubertal development induced by exposure of short-day males to an adult female. these results suggest that pineal melatonin mediates photoperiodic, but not social, control of pubertal develo ...19846512757
hypothyroidism in reproductively inhibited prairie deer mice (peromyscus maniculatus bairdi) from laboratory populations.several thyroid function parameters were compared between reproductively inhibited prairie deer mice of both sexes taken from laboratory populations and corresponding reproductively capable controls. the results of these experiments indicated the following: 1) prairie deer mice females had a statistically significant daily variation in mean serum thyroxine concentration and males displayed a similar trend; 2) total serum thyroxine and triiodothyronine were significantly lower in both male and fe ...19846518231
rhythms of barbiturate-induced sleep time in deermice entrained to non-twenty-four hour photocycles.the present experiment examined whether entrainment to twenty-four hour days is advantageous for physiological and behavioral adaptations to a pharmacological challenge. adult, male deermice (peromyscus maniculatus) were injected with sodium pentobarbital at 8.5, 14.5, 20.5, 2.5 and again at 8.5 hr after light onset while entrained to a 24 hr day (light/dark (ld) 14:10). time to recover from anesthesia was recorded. subsequently, the dark phase of the ld cycle was reduced 15-20 min every 10 days ...19836635008
pathogenesis of trypanosoma brucei infection in deer mice (peromyscus maniculatus). v. macrophage ultrastructure and function.macrophage numbers increased in the spleen, liver, testes, heart, and kidney of deer mice infected for seven to ten weeks with trypanosoma brucei eatro 110. the macrophages were activated as indicated by their increased size and significant increases in numbers of cell organelles including profiles of rough endoplasmic reticulum (which also increased in length), mitochondria, primary and secondary lysosomes, bundles of golgi's apparatus, and free lysosomes compared to macrophages from control mi ...19836636469
development and characterization of a homologous radioimmunoassay for deer mouse (peromyscus maniculatus bairdii) prolactin.a highly specific and sensitive homologous radioimmunoassay has been developed for the secreted form of prolactin from the deer mouse peromyscus maniculatus bairdii. peromyscus serum and pituitary homogenates displayed parallel dilution response curves, and no cross reaction was seen with either mouse prolactin, mouse growth hormone or rat prolactin. the assay was sensitive to 25 picograms per tube and the intra- and inter-assay coefficients of variation were 5 and 3.6%, respectively. in additio ...19836645802
latitude of origin influences photoperiodic control of reproduction of deer mice (peromyscus maniculatus).three subspecies of peromyscus maniculatus originating from different latitudes were maintained from birth in light dark cycles that provided between 10 and 18 h of light per day. at 50 days of age, chihuahua, mexico mice (latitude of origin 27 degrees n) and south dakota, u.s.a. mice (44 degrees n) kept in the 10l:14d photoperiod had reduced gonadal and seminal vesicle weights and a lower spermatogenic index than corresponding mice kept in a 14l:10d photoperiod. some chihuahua and south dakota ...19836681991
influence of feeding chlorocholine chloride and glyphosine on selected immune parameters in deer mice, peromyscus maniculatus.exposure to the plant growth regulators, chlorocholine chloride (ccc) and glyphosine (gps), resulted in significant immunomodulatory effects after feeding to deer mice (peromyscus maniculatus) for 28 days. cyclophosphamide (cp) and saline controls were included. both ccc and gps feeding levels were equivalent to 1, 10, 20, 40 and 80 mg/kg mouse/day. the parameters assessed were: spleen plaque forming cell (pfc) assays, hemolysin titers, white blood cell counts, bone marrow cellularity, hematocri ...19846710535
naloxone inhibition of stress-induced daily torpor.peromyscus maniculatus, deermice , were induced into daily torpor by restricting food to one-half daily ration. intraperitoneal injection of naloxone (20 mg/kg) into mice habituated to daily ip injections of saline inhibited or modified the expression of daily torpor. in those individuals demonstrating long duration/deep bouts (greater than 300 min/body temperature 20 degrees c or below) naloxone administration resulted in 1) a significant decrease in the duration of torpor, 2) a significant ele ...19846727554
effects of ingestion of chlorocholine chloride and cyclophosphamide on venezuelan equine encephalitis virus infections in deer mice (peromyscus maniculatus).we investigated the effects of chlorocholine chloride (ccc), a plant growth regulator, and cyclophosphamide (cp), a known immunosuppressant, on the ability of deer mice (peromyscus maniculatus) to resist challenge with a sublethal dose of venezuelan equine encephalitis virus ( veev ). the toxicants were continuously delivered in low doses in the feed; cp at 20 mg/kg body wt/day and ccc at 1, 10, 20 or 40 mg/kg body wt/day. mice were inoculated with 3 x 10(4) plaque forming units (pfu) of veev af ...19846729837
pathogenesis of trypanosoma brucei infection in deer mice (peromyscus maniculatus). ultrastructural pathology of the spleen, liver, heart, and kidney.trypanosoma brucei eatro 110 infection of the deer mice (peromyscus maniculatus) produced moderate to marked lesions in the spleen, liver, heart, and kidney seven to ten weeks after infection. splenic lesions consisted of marked splenomegaly, with infected spleens weighing 25.9 times control spleens. transmission electron microscopy of the sinuses and billroth's cords of the splenic red pulp demonstrated an increased cellularity with greater contact between cells due partly to proliferation of m ...19846730206
pathogenesis of trypanosoma brucei infection in deer mice (peromyscus maniculatus). light and electron microscopic study of testicular lesions.the results of light and electron microscopic studies demonstrated that trypanosoma brucei infection produced marked testicular degeneration in deer mice (peromyscus maniculatus) with highly significant (p less than 0.001) decreases in testicular weight, seminiferous tubular diameter, and epithelial thickness. lesions in seminiferous tubules consisted of necrosis of spermatids, spermatocytes, and sometimes the spermatogonia. sertoli's cells had marked vacuolation and accumulation of phagocytic m ...19846730207
maximum oxygen consumption during exercise and cold exposure in deer mice, peromyscus maniculatus.convenient methods were developed for measuring maximum oxygen consumption (vo2 max) in untrained small mammals during treadmill exercise and cold exposure. deer mice (peromyscus maniculatus) were run once, for 6-min periods at velocities exceeding maximal aerobic running speed, while instantaneous oxygen consumption was measured. the vo2 max during cold exposure was determined using high wind speeds to increase heat loss rates. during running, the kinetics of gas exchange were rapid and similar ...19846739991
hepatic aldehyde dehydrogenase activity in peromyscus genetically deficient in alcohol dehydrogenase.1. hepatic aldehyde dehydrogenase (aldh) activity was measured in two strains of deer-mouse, peromyscus maniculatus. 2. there is no difference in the subcellular distribution of aldh activity in the two strains. animals of adhn/adhn genotype, lacking liver alcohol dehydrogenase (adh), had 90% of total aldh activity in the mitochondrial fraction compared to 94% for the adhf/adhf animals with normal adh activity. almost all of the remaining aldh activity was in the hepatic cytosol with less than 1 ...19826751681
immunological factors in peromyscus speciation.reciprocal interspecific f1 hybrids of deermice (peromyscus maniculatus) and oldfield mice (p. polionotus) differ significantly and substantially in fetal and placental, as well as adult, size and weight. hybrid fetal mortality is associated with large conceptus size. skin grafts were exchanged between and within the two species to ascertain whether any relationship exists between mean graft retention time and body size of fetuses and adults. p. maniculatus skin grafted to p. polionotus rejected ...19826757375
sarcocystis idahoensis sp. n. in deer mice peromyscus maniculatus (wagner) and gopher snakes pituophis melanoleucus (daudin). 19806768882
transmission studies with sarcocystis idahoensis of deer mice (peromyscus maniculatus) and gopher snakes (pituophis melanoleucus).transmission studies with sarcocystis idahoensis of deer mice (peromyscus maniculatus) and gopher snakes (pituophis melanoleucus) were conducted to determine host specificity of various stages of the parasite. sporocysts were not passed by four dogs or four cats fed infected skeletal muscle from deer mice. seven white mice (mus musculus) and 34 white-footed mice (peromyscus leucopus) were negative for sarcocysts and liver meronts following oral inoculation with s. idahoensis sporocysts; however, ...19806776292
isolation, purification, and characterization of deer mouse (peromyscus maniculatus bairdii) prolactin.prolactin (prl) secreted by peromyscus maniculatus bairdii anterior pituitaries was purified by gel filtration on sephadex g-100 and ion-exchange chromatography on deae-cellulose. peromyscus prl (pmprl) eluted from sephadex g-100 with an elution-to-void volume ratio of 1.9 and at a salt concentration of 100 mm nacl on deae-cellulose. electrophoretic homogeneity of the hormone was demonstrated in several gel systems. on 7 1/2% alkaline polyacrylamide gels, pmprl migrated with an rf of 0.65. the m ...19836847207
photoperiodic stimulation of pubertal development in male deer mice: involvement of the circadian system.pubertal development in prairie deer mice (peromyscus maniculatus bairdii) is accelerated by exposure of juveniles to a long-day photoperiod, and, conversely, retarded by exposure to short days. the purpose of the present study was to evaluate the possible involvement of the circadian system in the photoperiodic regulation of puberty. weanling males, previously housed on a short-day light cycle of 6l:18d, were subjected to a "resonance" protocol in which they received one of the following light ...19836850042
juvenile ataxia--a new behavioral mutation in the deermouse.an autosomal recessive behavioral mutation designated juvenile ataxia (ja) was first isolated from f2 progeny of four blonde (bl) peromyscus maniculatus bairdi siblings. juvenile ataxic homozygotes exhibit an ataxic gait without an associated tremor from 15 days postpartum. this ataxia continues but does not increase noticeably in severity until between 35 and 43 days of age. thereafter, a rapid and dramatic improvement in the behavior pattern is seen, so that juvenile ataxic deermice over 45 da ...20036863895
pathogenesis of trypanosoma brucei infection in deer mice (peromyscus maniculatus): hematologic, erythrocyte biochemical, and iron metabolic aspects.trypanosoma brucei eatro 110 infection in deer mice (peromyscus maniculatus) produced anemia in 15 of 42 mice between postinoculation days 14 and 70. the infected anemic (ia) mice had significantly higher reticulocyte counts (p less than 0.025), spleen (p less than 0.001) and liver (p less than 0.005) weights, and higher parasitemia than did infected nonanemic (ina) mice. gamma-globulin concentrations of infected mice were markedly increased, and values for ina mice were 10% higher than values f ...19836869960
pathogenesis of trypanosoma brucei infection in deer mice (peromyscus maniculatus): light and electron microscopic studies on erythrocyte pathologic changes and phagocytosis.light microscopic and scanning and transmission electron microscopic studies demonstrated that trypanosoma brucei eatro 110 produced several alterations in rbc structure including microspherocytes, schistocytosis, vacuolation, doughnut-cell formation, and keratocytosis. mature rbc and reticulocytes were constantly observed to adhere firmly to trypanosomes in heart blood and in blood vessels of the testes, heart, liver, and kidney, as well as in the sinuses and pulp cords of the spleen. adhesion ...19836869961
gonadal hormone activation of male courtship ultrasonic vocalizations and male copulatory behavior in castrated male deer mice (peromyscus maniculatus bairdi).the influence of testosterone (t), a 5 alpha-reduced metabolite of t, dihydrotestosterone, and an aromatized metabolite of t, estradiol, on 35-khz ultrasonic calling and male copulatory behavior by male deer mice (peromyscus maniculatus bairdi) was examined. daily treatment with testosterone propionate (tp), dihydrotestosterone propionate (dhtp), or estradiol benzoate (eb) restored male ultrasonic calling in long-term castrated males. both tp and dhtp restored male copulatory behavior, but eb wa ...19836871034
recovery from sexual satiety in deer mice (peromyscus maniculatus bairdi).two experiments were completed in order to delineate the time course of recovery from sexual satiety in deer mice, peromyscus maniculatus bairdi. the total numbers of ejaculations and intromissions attained in satiety tests were significantly decreased on the day following satiation and recovered gradually as measured in tests run after 3 and 7 days of recovery. whereas some measures characteristic of individual series were altered by incomplete recovery, others were unaffected. in experiment 2, ...19836872505
influence of photoperiod and social environment on sexual maturation in female deer mice (peromyscus maniculatus bairdii).female deer mice (peromyscus maniculatus) were reared on either a long photoperiod (15:9 hr light/dark) or on short days (8:16 hr light/dark) from birth. beginning at weaning, females were housed with an adult male, with an adult female, or in social isolation. in the first experiment, vaginas opened more slowly in females on short days than in those on long days. vaginal introitus was also retarded in females reared with an adult female in comparison with females reared in isolation. when exami ...19836872508
testosterone acts as a prohormone to stimulate male copulatory behavior in male deer mice (peromyscus maniculatus bairdi).in order to determine the importance of reduced and aromatized metabolites of testosterone for male sexual behavior in peromyscus maniculatus bairdi, castrated males were treated with 5 alpha-reductase and aromatase inhibitors. in the first experiment, testosterone propionate (tp) activation of male copulatory behavior was blocked by the administration of the 5 alpha-reductase inhibitor 4-androsten-3-one-17-beta carboxylic acid (17 beta c). these treatments also prevented tp stimulation of semin ...19827056894
blonde, a new mutation in peromyscus maniculatus affecting fur, skin, and eye pigmentation.an autosomal recessive mutation affecting hair and eye pigmentation was discovered in the f2 progeny of wild-type deer mice, (peromyscus maniculatus), trapped near east lansing, michigan. when homozygous, the mutation (designated as blonde, bl), reduces both black and yellow pigmentation deposited in the fur, reduces or eliminates pigmentation in the non-follicular melanocytes of the outer ear, peri-orbital skin and tail, slightly reduces the amount of pigmentation in the choroidal melanocytes, ...20037069191
feeding pattern in peromyscus maniculatus: the response to periodic food deprivation.the prairie deermouse (peromyscus maniculatus bairdi) is strongly nocturnal on a 12:12 ld-cycle with a bimodal, dusk-dawn feeding pattern. it has been suggested for the rat that the dusk peak is more dependent on the animal's immediate energy needs while the dawn peak has an anticipatory function in storing food. the present study investigates this pattern in terms of the feeding response of deermice following periodic food deprivation. it was found that the response is not uniform within the d- ...19827079329
social stimulation of reproductive development in male deer mice housed on a short-day photoperiod.male deer mice (peromyscus maniculatus), born of mothers housed on a long-day (ld) photoperiod (15:9 hr light/dark), were either switched to a short-day (sd) photoperiod (6:18 hr) at birth or continued on their prenatal ld photoperiod. from weaning until 6 wk of age, the males were housed either in cohabitation with an adult female or in social isolation. males reared on an sd photoperiod had smaller testes, seminal vesicles, and ventral sebaceous glands than did males reared on ld. postweaning ...19827096680
2,3-diphosphoglycerate in high- and low-altitude populations of the deer mouse.erythrocyte dpg concentrations were studied in populations of peromyscus maniculatus native to different altitudes. deer mice native to, and resident at, high altitude showed higher dpg/hb ratios than did deer mice native to, and resident at, low altitude. however, after prolonged acclimation to low altitude, the high-altitude natives showed lower dpg/hb ratios than did low-altitude natives. the differences in baseline dpg levels appear to be determined primarily by genetic factors. the heritabi ...19827111916
blood oxygen affinity in high- and low-altitude populations of the deer mouse.there is little solid evidence for specific genetic adaptations in animal populations native to high altitude. there is also continuing debate over what oxygen transport characteristics are truly adaptive at high altitude. we have attempted to elucidate both problems through population genetic and physiological studies of the deer mouse, peromyscus maniculatus. that species is noteworthy because it inhabits the widest range of altitudes of any north american mammal, and it shows a high degree of ...19827111920
an assessment of "hidden" heterogeneity within electromorphs at three enzyme loci in deer mice.allelic heterogeneity within protein electromorphs at three loci was examined in populations of deer mice (peromyscus maniculatus) collected from five localities across north america. we used a variety of electrophoretic techniques (including several starch and acrylamide conditions, gel-sieving, and isoelectric focusing) plus heat denaturation. of particular interest was the supernatant glutamate oxalate transaminase system (got-1; aspartate aminotransferase-1 of some authors), which under stan ...19827152246
aggressive behaviour of female prairie deer mice in laboratory populations.prairie deer mice (peromyscus maniculatus bairdii), living in asymptotic laboratory populations established two years earlier, were observed for agonistic responses to conspecific intruders. in the first experiment, intruders of six age-sex classes were placed into 10 of the populations for 10 min. the sex of the intruder did not influence the behaviour of the residents, but juveniles elicited more regression than did adults. a second experiment revealed that female residents were responsible fo ...19807194609
effects of urine from conspecifics on sexual maturation in female prairie deermice, peromyscus maniculatus bairdii. 19807217792
male sexual behavior in deer mice (peromyscus maniculatus) following castration and hormone replacement. 19817250909
ultrasonic vocalizations in male deer mice (peromyscus maniculatus bairdi): their role in male sexual behavior. 19817323194
cataract-webbed trait in peromyscus. ii. biomicroscopy and histology of eyes.a longitudinal biomicroscopic study of lenses and fundi of over 2,000 peromyscus maniculatus (deer mice) which have cataracts as an autosomal recessive trait has been correlated with histologic development of cataracts. by selective breeding, early-onset cataracts (type i), which are frequently associated with abnormal closure of the fetal fissure and hyaloid vascular abnormalities, have been separated from later-onset (type ii) cataracts, which are more heterogeneous. type i cataracts occur in ...19807350132
experimental trypanosoma brucei infection in deer mice: splenic changes.forty deer mice (peromyscus maniculatus) were infected with trypanosoma brucei organisms and were killed 33 to 83 days after inoculation (average, 63). the outstanding lesion was infiltration of plasma cells in various tissues. these cells caused disruption of the periarteriolar lymphocytic sheaths and thickening of red pulp cords in the spleen. the lymph node was almost completely replaced by plasma cells. the spleen and lymph nodes also had marked hyperplasia of germinal centers and granulomat ...19807361379
ultrastructure and acid phosphatase activity in hereditary cataracts of deer mice.lenses of cataract-webbed (cw) peromyscus maniculatus were examined by electron microscopy and compared to age-matched normal deer mouse lenses. precataractous lenses of offspring of cw/cw matings were examined and compared to early cataract development in the opposite eye of the same animal. the earliest ultrastructural change leading to disturbance of lens transparency was cell fusion and formation of fiber cell syncytia in the posterior subcapsular region. fiber cells lost their regular hexag ...19807390724
a study of hetero-specific sperm-egg interactions in the rat, mouse, and deer mouse using in vitro fertilization and sperm injection.hetero-specific fertilization of zone-free eggs is used in these experiments as a tool to analyze the barriers to hybridization and to gain insight into the mechanisms of normal fertilization. when the zonae of rat eggs, which are a barrier to hetero-specific fertilization, are removed with pronase, the eggs can be fertilized by mouse sperm and the zygotes start to develop normally. a rat egg fertilized with mouse sperm completes meiosis and forms both male and female pronuclei. chromosomes from ...19807420048
baseline levels of selected trace elements in colorado oil shale region animals.baseline levels of boron, fluorine, molybdenum, and copper are described for 18 mule deer (odocoileus hemionus) and for 45 composite samples of deer mice (peromyscus maniculatus) from the piceance creek basin, rio blanco county, colorado. these data were collected before oil shale mining took place, and can be used to compare with levels found after mining is initiated. the data can thus be used to monitor changes in levels in animal tissues and as a basis for mitigating possible harmful effects ...19807431515
sex affects the initial strength but not the extinction of poison-based taste aversions in deer mice (peromyscus maniculatus bairdi). 19807447866
evolutionary conservation of linkage groups: additional evidence from murid and cricetid rodents.in mus musculus, family muridae, the glucosephosphate isomerase (gpi-l), pink-eyed dilution (p), albinism (c), and beta-type globin (hbb) loci are known to be linked in the order gpi-l-p-c-hbb. in rattus norvegicus, another murid rodent, the p, c, and hbb loci are known to be linked in the same order and with similar recombination frequencies. in peromyscus maniculatus, family cricetidae, it was previously known that p and c are linked and by analogy to mus musculus that linkage group should be ...19807447921
social factors influencing delayed reproductive maturation in prairie deermice (peromyscus maniculatus bairdii) in laboratory populations. 19807462866
modes of ectoparasite reinfestations of deer mice (peromyscus maniculatus).modes of ectoparasite reinfestations were studied on ectoparasite-free deer mice (peromyscus maniculatus) returned to their natural habitat on the tule lake national wildlife refuge, siskiyou county, california, during the summer of 1977. the age of the host made no significant difference in the mode of reinfestation of lice, fleas, or mites. flea reinfestation rates were related to the sex of the host, requiring 4 and 2 days, respectively, to reach control levels on male and female hosts. mite ...19807463612
coexistence of several novel hantaviruses in rodents indigenous to north america.three genetically distinct members of the hantavirus genus have been detected in nevada rodents by rt-pcr and nucleotide sequence analysis. these include sin nombre (sn), el moro canyon (elmc), and prospect hill (ph)-like viruses which are primarily associated with peromyscus maniculatus (deer mouse), reithrodontomys megalotis (western harvest mouse), and microtus spp. (voles), respectively. although this region of the united states is ecologically diverse, rodents infected with different hantav ...19957483255
complete genetic characterization and analysis of isolation of sin nombre virus.this study reports completion of the genetic characterization of the entire genome of sin nombre (sn) virus (nmh10) detected in autopsy tissues from a patient who died of hantavirus pulmonary syndrome (hps). the large (l) genome segment was found to be 6,562 nucleotides in length and encoded a putative l polymerase that was 2,153 amino acids in length. no evidence of segment reassortment with other well-characterized hantaviruses was obtained. the sequence of the entire s, m, and l genome segmen ...19957494336
p-nitrosophenol reduction by liver cytosol from adh-positive and -negative deermice (peromyscus maniculatus).liver cytosolic fractions are known to catalyze the reduction of certain c-nitroso compounds to their corresponding hydroxylamines and amines. alcohol dehydrogenase (adh), nad(p)h:quinone oxidoreductase, and xanthine and aldehyde oxidases have been implicated as c-nitroso reductases. to probe the role of these cytosolic enzymes in the reduction of c-nitroso compounds we have studied the effects of classical inhibitors of these enzymes on the ability of liver cytosolic fractions from adh+ and adh ...19957532387
differential testicular responses to short daylength in deer mice are reflected by regional and morphological differences in the gnrh neuronal system.male deer mice (peromyscus maniculatus) respond to short photoperiod with a range of spermatogenic responses. about one-third of all short day exposed mice exhibit a complete cessation of spermatogenesis (reproductive responsive), while about an equal number remain reproductively competent (reproductive nonresponsive). these differential spermatogenic responses are mirrored by endocrine measures; reproductive responsive males exhibit reduced circulating levels of testosterone and luteinizing hor ...19957583239
transmission of borrelia burgdorferi by ixodes pacificus nymphs and reservoir competence of deer mice (peromyscus maniculatus) infected by tick-bite.the transmission of borrelia burgdorferi to deer mice (peromyscus maniculatus) by ixodes pacificus nymphs was investigated experimentally. deer mice were exposed to infected nymphs for 24, 48, or 72 hr, or until ticks had fed to repletion (> or = 96 hr). infection status of hosts was assessed 4 wk later by culture of ear-punch biopsies in bsk ii medium and by indirect immunofluorescence. eight mice exposed to ticks for 24 hr did not become infected. in contrast, infection was acquired by 1 of 9 ...19957707191
oocyst output, periodicity, and immunity of two deer mouse (peromyscus maniculatus) eimerians (eimeria arizonensis and eimeria delicata).we compared the life histories of 2 eimerians (eimeria arizonensis and eimeria delicata), which co-occur in the deer mouse (peromyscus maniculatus). laboratory-reared deer mice were given 10(3), 10(4) (e. delicata), or 10(3), 10(4), or 10(5) (e. arizonensis) oocysts by stomach intubation. eimeria arizonensis infections lasted longer (11-13 days) than e. delicata infections (9-10 days). eimeria arizonensis infections also produced more oocysts for each oocyst ingested at both levels compared. bot ...19957707193
toxicological foundations of ecological risk assessment: biomarker development and interpretation based on laboratory and wildlife species.ecological risk assessments based on chemical residue analysis and species demographics tend to ignore the bioavailability and bioaccumulation of the chemicals of concern. this study describes the incorporation of mechanistically based biomarkers into an ecological risk assessment of a poly-cyclic aromatic hydrocarbon (pah)-contaminated site. a combination of soil residue analysis, tissue residue analysis, biomarkers in one-site trapped animals and biomarkers in animals confined to enclosures wa ...19947713037
a household-based, case-control study of environmental factors associated with hantavirus pulmonary syndrome in the southwestern united states.during an outbreak of hantavirus pulmonary syndrome (hps) in the southwestern united states, trained environmental assessment teams conducted surveys at 17 case-patient homes and matched controls from june through august 1993. variables related to rodent abundance were quantified and standardized rodent trapping was conducted around and within households. the majority of households were located in pinon-juniper vegetation zones, and there were no significant differences in the type of house in w ...19957771603
photoperiodic effects on tumor development and immune function.seasonal changes in adaptations associated with winter coping strategies have been frequently studied. central among the suite of energy-saving, winter-coping strategies is the suspension of reproductive activities. the inhibition of reproduction by nontropical rodents is mediated by daylength changes. although balanced annual energy budgets are critical, survival and subsequent reproductive success also require avoiding predators, illness, and early death. because the stressors of winter could ...19947772792
distribution of borrelia burgdorferi in host mice in pennsylvania.host mice (peromyscus leucopus and peromyscus maniculatus) were sampled throughout the state of pennsylvania to determine the geographical and ecological distribution of the lyme disease spirochete borrelia burgdorferi. all 67 counties of the state were sampled. a total of 1,619 mice were captured from a total of 157 sites during the period 1990 to 1993 for an overall capture rate of 29.69%. a total of 112 (6.92%) isolations of b. burgdorferi were made. the distribution of isolations revealed th ...19947814489
antibody responses to four corners hantavirus infections in the deer mouse (peromyscus maniculatus): identification of an immunodominant region of the viral nucleocapsid protein.antibody responses to four corners hantavirus (fcv) infections in the deer mouse (peromyscus maniculatus) were characterized by using fcv nucleocapsid protein (n), glycoprotein 1 (g1), and glycoprotein 2 (g2) recombinant polypeptides in western immunoblot assays. strong immunoglobulin g reactivities to fcv n were observed among fcv-infected wild p. maniculatus mice (n = 34) and in laboratory-infected p. maniculatus mice (n = 11). no immunoglobulin g antibody reactivities to fcv g1 or g2 linear d ...19957853538
a newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in louisiana.genetic analysis of virus detected in autopsy tissues of a fatal hantavirus pulmonary syndrome-like case in louisiana revealed the presence of a previously unrecognized hantavirus. nucleotide sequence analysis of pcr fragments of the complete s and m segments of the virus amplified from rna extracted from the tissues showed the virus to be novel, differing from the closest related hantavirus, sin nombre virus, by approximately 30%. both genome segments were unique, and there was no evidence of g ...19957853545
isolation and initial characterization of a newfound hantavirus from california.a fatal case of hantavirus pulmonary syndrome (hps) in northern california prompted our attempt to isolate viruses from local rodents. from tissues of two deer mice, peromyscus maniculatus, two hantaviruses (convict creek virus 107 and 74, cc107 and cc74) were established in cell culture. viral antigens, proteins, and rnas of the first and archetypical isolate (cc107) were examined, and portions of the medium (m) and small (s) genome segments of both isolates were sequenced. antigenically, cc107 ...19957856107
complete nucleotide sequences of the m and s segments of two hantavirus isolates from california: evidence for reassortment in nature among viruses related to hantavirus pulmonary syndrome.we report the complete nucleotide sequence of the m and the s genome segments and a portion of the l segments of two hantavirus isolates from peromyscus maniculatus trapped in eastern california. the isolates, convict creek 107 and 74 (cc107 and cc74) are genetically similar to viruses known to cause hantavirus pulmonary syndrome in new mexico. cc107 and cc74 each have an m segment consisting of 3696 nucleotides with a coding potential of 1140 amino acids in the virus complementary-sense rna (cr ...19957856108
etiology and epidemiology of the four corners hantavirus outbreak.in may and june 1993, a handful of previously healthy residents of rural areas in the four corners region of the southwestern united states died of acute unexplained respiratory distress, later diagnosed as hantavirus pulmonary syndrome. their illnesses were characterized most prominently by a prodrome of fever and myalgias, followed by thrombocytopenia, the presence of immature white blood cells on the peripheral smear, and catastrophic respiratory decline associated with the sudden onset of no ...19947866656
short report: prevalence of hantavirus infection in rodents associated with two fatal human infections in california.rodents living near two fatal human cases of hantavirus pulmonary syndrome in california were surveyed for evidence of hantavirus infection. seventeen (15%) (14 peromyscus maniculatus and one each of p. truei, eutamias minimus, and microtus californicus) of 114 rodents tested had evidence (enzyme-linked immunosorbent assay or polymerase chain reaction) of hantavirus infection. this suggests that peromyscus mice, and p. maniculatus in particular, may be the reservoir for the virus causing this ne ...19957872450
coccidian parasites (apicomplexa) from snakes in the southcentral and southwestern united states: new host and geographic records.four hundred thirty-five leptotyphlopid, colubrid, elapid, and viperid snakes were collected from various localities in arkansas, new mexico, oklahoma, and texas, and their feces were examined for coccidian parasites. of these, 131 (30%) were passing oocysts or sporocysts of at least 1 coccidian; 88 (67%) of the infected snakes had only 1 species of coccidian when they were examined. aquatic and semiaquatic snakes accounted for 48% of the infections, whereas strictly terrestrial snakes comprised ...19957876980
hantavirus pulmonary syndrome. pathogenesis of an emerging infectious disease.a recent outbreak of a severe pulmonary disease in the southwestern united states was etiologically linked to a previously unrecognized hantavirus. the virus has been isolated from its major reservoir, the deer mouse, peromyscus maniculatus, and recently named sin nombre virus. clinically, the disease has become known as the hantavirus pulmonary syndrome (hps). since may 1993, 44 fatal cases of hps have been identified through clinicopathological review and immunohistochemical (ihc) testing of t ...19957887439
natural and experimental borrelia burgdorferi infections in woodrats and deer mice from california.sequestration of spirochetes and concurrent histopathologic lesions were evaluated in tissues of borrelia burgdorferi-infected dusky-footed woodrats (neotoma fuscipes) and deer mice (peromyscus maniculatus). rodents were either wild-caught and naturally infected or were experimentally infected by tick bite, by intramuscular (i.m.) injection of cultured spirochetes, or by i.m. injection of tick suspensions. samples of host tissues, including skin, blood, ear, brain, eye, heart, lung, liver, splee ...19947933283
genetic evidence for a hantavirus enzootic in deer mice (peromyscus maniculatus) captured a decade before the recognition of hantavirus pulmonary syndrome.to determine if the emergence of hantavirus pulmonary syndrome in the united states was a consequence of recent amino-acid altering mutations and/or genetic reassortment with pathogenic hantaviruses, we examined lung and spleen tissues from seropositive deer mice trapped in august 1983 in mono county, california, for hantaviral rna by reverse transcriptase-directed polymerase chain reaction. alignment and comparison of 1485 nucleotides of the s and m genomic segments enzymatically amplified from ...19947941323
bioavailability of metals and arsenic to small mammals at a mining waste-contaminated wetland.in support of a baseline ecological risk assessment evaluating the impacts of mining wastes at the milltown reservoir sediments superfund site in montana, a food chain transfer analysis was performed for resident small mammals. deer mice (peromyscus maniculatus) and meadow voles (microtus pennsylvanicus) were trapped from a 200 a portion of a mixed upland and palustrine wetland, and concentrations of as, cd, cu, pb, and zn in carcass, liver, kidney, and testes were quantified. concurrent to smal ...19948024321
vector competence of ixodes pacificus and dermacentor occidentalis (acari: ixodidae) for various isolates of lyme disease spirochetes.the vector competence of the western black-legged tick, ixodes pacificus cooley & kohls, and the pacific coast tick, dermacentor occidentalis marx, for the lyme disease spirochete (borrelia burgdorferi johnson, schmid, hyde, steigerwalt & brenner) was compared. rabbits, hamsters, and the deer mouse, peromyscus maniculatus (wagner), were injected with cultured spirochetes or infected tick-suspensions, or were fed upon by spirochete-infected ticks. five of seven isolates used as inocula were reiso ...19948057316
isolation of the causative agent of hantavirus pulmonary syndrome.investigation of a recent outbreak of acute respiratory illness in the southwestern united states resulted in the recognition of a new disease, hantavirus pulmonary syndrome (hps) with high mortality. different animals and cell lines were used in attempts to isolate the causative agent. a previously unknown hantavirus was passaged in laboratory-bred deer mice, recovered from lung tissues of a deer mouse, peromyscus maniculatus, and propagated in the e6 clone of vero cells. virus antigen was read ...19948059907
day length affects immune cell numbers in deer mice: interactions with age, sex, and prenatal photoperiod.the extent to which day length affects immune function was examined in the present study. three goals were pursued: 1) to confirm and extend the observation that the immune systems of adult deer mice (peromyscus maniculatus) are responsive to changes in photoperiod, 2) to examine the development of the photoperiod-associated changes in immune function, and 3) to discover whether photoperiodic information transmitted to the young during gestation influences immune function. in experiment 1, adult ...19948067473
comparison of chromosomal distribution of a retroposon (line) and a retrovirus-like element mys in peromyscus maniculatus and p. leucopus.chromosomal distribution for two interspersed elements (lines and mys) that are thought to have established their chromosomal position primarily by transposition was compared between two species of deer mice (peromyscus leucopus and p. maniculatus). both lines and mys generally produced an autosomal banding pattern reflective of g-bands and both hybridized preferentially to the sex chromosomes. the pattern on the long arm of the x was unique for each, with mys reflecting the g-bands (four bands ...19948069462
role of gonadal steroids and inhibitory photoperiod in regulating body weight and food intake in deer mice (peromyscus maniculatus).we investigated the role of declining daylength and gonadal steroids on body weight and food intake in male deer mice (peromyscus maniculatus). this species was chosen for study because individual males display different reproductive responses to inhibitory daylength. about one-third of all mice exposed to short days undergo testicular regression and exhibit reduced circulating levels of luteinizing hormone and testosterone (reproductive responsive males). in contrast, testicular function and ci ...19948073049
coat color genetics of peromyscus: iv. variable white, a new dominant mutation in the deer mouse.the variable white mutation arose spontaneously in 1983 within a laboratory stock of wild-type deer mice (peromyscus maniculatus). the original mutant animal was born to a wild-type pair that had previously produced several entirely wild-type litters. other variable white animals were bred from the initial individual. variable white deer mice exhibit extensive areas of white on the head, sides, and tail. usually a portion of pigmented pelage occurs dorsally and on the shoulders, but the extent o ...19948120357
[pulmonary syndrome caused by hantavirus--a new syndrome with high mortality].an outbreak of a previously unknown, severe infectious disease with rapidly fatal respiratory distress was reported from southwestern usa in may 1993. the case fatality rate was about 60 per cent. using pcr hantavirus rna could be demonstrated in lungs and other tissues from patients. mice and others rodents, e g peromyscus maniculatus, were shown to be a reservoir of the virus. this new virus, designated four corner virus, has been further characterised and seems to be closely related to puumal ...19948139902
sexually dimorphic spatial learning varies seasonally in two populations of deer mice.spatial learning in photoperiodically induced breeding (reproductive) and non-breeding (non-reproductive) adult male and female deer mice (peromyscus maniculatus) was examined in a morris water-maze task. sexually mature, adult male and female deer mice that were derived from either a mainland population (p. m. artemisiae) or an island population (p. m. angustus) were required to learn the spatial position of a hidden, submerged platform in a water maze. deer mice were tested either during the b ...19948173954
h-2t24 and pemat24: orthologous expressed mhc class ib genes from mouse and peromyscus maniculatus. 19948188318
serologic and genetic identification of peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern united states.an outbreak of hantavirus pulmonary syndrome (hps) in the southwestern united states was etiologically linked to a newly recognized hantavirus. knowledge that hantaviruses are maintained in rodent reservoirs stimulated a field and laboratory investigation of 1696 small mammals of 31 species. the most commonly captured rodent, the deer mouse (peromyscus maniculatus), had the highest antibody prevalence (30%) to four hantavirus antigens. antibody also was detected in 10 other species of rodent and ...19948195603
comparative toxicity of azinphos-methyl to house mice, laboratory mice, deer mice, and gray-tailed voles.a laboratory toxicity study on house mice and laboratory mice (mus musculus), gray-tailed voles (microtus canicaudus), and deer mice (peromyscus maniculatus) was conducted as part of a comprehensive laboratory and field study to field validate laboratory-based risk assessment of pesticides. the single dose oral ld50 for the organophosphorus insecticide azinphos-methyl (guthion) was 10, 11, 32, and 48 mg/kg body weight in wild house mice, laboratory mice, gray-tailed voles, and deer mice, respect ...19948198427
molecular basis of the alcohol dehydrogenase-negative deer mouse. evidence for deletion of the gene for class i enzyme and identification of a possible new enzyme class.the molecular basis of the alcohol dehydrogenase (adh)-negative deer mouse (peromyscus maniculatus) has been investigated. several classes of mammalian adhs have been recognized based upon biochemical and structural properties. adh cdna clones identified by hybridization to a mouse class i adh cdna clone were obtained from a deer mouse adh-positive liver cdna library. this cdna has been identified as being a class i sequence and represents the deer mouse adh-1 gene. an additional cdna sequence i ...19938227055
genetic identification of a hantavirus associated with an outbreak of acute respiratory illness.a mysterious respiratory illness with high mortality was recently reported in the southwestern united states. serologic studies implicated the hantaviruses, rodent-borne rna viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. a genetic detection assay amplified hantavirus-specific dna fragments from rna extracted from the tissues of patients and deer mice (peromyscus maniculatus) caught at or near patient residences. nucleotide sequence analysis revealed ...19938235615
winter adaptations of male deer mice (peromyscus maniculatus) and prairie voles (microtus ochrogaster) that vary in reproductive responsiveness to photoperiod.individuals of many nontropical rodent species restrict breeding to the spring and summer. seasonal reproductive quiescence putatively reflects the energetic incompatibility of breeding and thermoregulatory activities. however, so-called "out-of-season" breeding occurs in virtually all rodent populations examined, suggesting that the incompatibility can be resolved. both reproductive inhibition and development of energy-saving adaptations are mediated by environmental photoperiod, but some indiv ...19938280911
sex differences in the antinociceptive effects of the enkephalinase inhibitor, sch 34826.the effects of endogenous opioid peptides are limited by proteolytic enzymes such as endopeptidase 24.11 ("enkephalinase"), which cleaves the gly-phe bonds in met- and leu-enkephalin. sch 34826 [(s)-n-[n-[1-[(2,2-dimethyl-1,3-dioxolan-4- yl)methoxy]carbonyl]-2-phenylethyl]-l-phenyl-alanine-b-alanine] is a potent, highly specific, enkephalinase inhibitor that has marked analgesic effects in laboratory rodents. the present study compared the effects of sch 34826 on nociception and restraint stress ...19938309954
coat color genetics of peromyscus: ii. tan streak--a new recessive mutation in the deer mouse, p. maniculatus.the first mutant tan streak deer mice appeared in the initial laboratory-bred generation of a stock of peromyscus maniculatus nubiterrae collected in macon county, north carolina. laboratory progeny from the original animals were bred and mated among themselves and to wild-type individuals. the tan streak phenotype is characterized by nearly complete absence of coat pigmentation, except for a pale tan patch or narrow stripe extending mid-dorsally posteriorly from the head. the band is frequently ...19938340619
enteral and parenteral phases of trichinella nativa and trichinella pseudospiralis in the deer mouse, peromyscus maniculatus.trichinella nativa and trichinella pseudospiralis infections in a wild rodent host, the deer mouse (peromyscus maniculatus), were characterized. forty-six percent of 400 inoculated t. nativa were recovered on day 4 postinoculation (pi); 77% and 23% were found in the small and large intestines, respectively. thirty-one percent of the worms recovered on day 4 remained in the large intestine beyond day 20 pi. worms were embedded in the mucosa of the small intestine, cecum, and colon. females recove ...19938410546
update: hantavirus pulmonary syndrome--united states, 1993.a unique hantavirus has been identified as the cause of the outbreak of respiratory illness (hantavirus pulmonary syndrome [hps]) first recognized in the southwestern united states in may 1993. the habitat of the principal rodent reservoir for this virus, peromyscus maniculatus (deer mouse), extends throughout most of the united states except the southeast. through october 21, 1993, hps has been confirmed in 42 persons reported to cdc from 12 states (figure 1). this report summarizes major clini ...19938413170
diurnal rhythms of 5-ht1a and 5-ht2 receptor binding in euthermic and torpor prone deermice, peromyscus maniculatus.deermice display both spontaneous and induced daily torpor bouts, attaining minimum body temperatures of 15-20 degrees c. there is evidence that brain serotonin may be involved in the initiation and/or maintenance of torpor. inhibition of serotonin [5-hydroxytryptamine (5-ht)] synthesis markedly reduces the duration and depth of torpor. because a certain percentage of deermice will not enter torpor under any circumstances, we were able to compare 5-ht receptor subtypes in deermice that readily e ...19938415817
season affects tolerance of cohabitation by deer mice.we measured the resting metabolic rates of peromyscus maniculatus for 7 days before and 7 days following forced pairing in order to determine whether seasonal light cycles influenced the rates of behavioral and metabolic habituation of deer mice to cohabitation. we had earlier shown that winter photoperiod and/or huddling results in lower resting metabolic rates and core temperatures of deer mice. seasonal photoperiods were simulated by conditioning wild-caught mice to 24-h light cycles with dif ...19938451332
growth regulation in peromyscus species hybrids: a test for mitochondrial-nuclear genomic interaction.interspecific hybridization of peromyscus maniculatus (deer mouse) and p. polionotus (oldfield mouse) is accompanied by pronounced size differences between reciprocal f1 animals beginning in the fetus and continuing throughout life. since the mitochondrial genome is inherited through the maternal line in peromyscus, we tested the hypothesis that increased disparity between the species sources of mitochondrial and nuclear genomes within animals would exaggerate the reciprocal size effects through ...19938495994
competence of peromyscus maniculatus (rodentia: cricetidae) as a reservoir host for borrelia burgdorferi (spirochaetares: spirochaetaceae) in the wild.although capable of maintaining and transmitting borrelia burgdorferi johnson, schmidt, hyde, steigerwalt & brenner, the causative spirochete of lyme disease, in the laboratory, the specific ability of deer mice, peromyscus maniculatus le conte, to support this zoonosis has not been established. demonstration that p. maniculatus is a competent reservoir host in the wild would indicate that the spread of lyme disease is not limited to the range of the primary reservoir host, p. leucopus rafinesqu ...19938510121
dehydrogenase-dependent metabolism of alcohols in gastric mucosa of deer mice lacking hepatic alcohol dehydrogenase.deer mice (peromyscus maniculatus) lacking hepatic alcohol dehydrogenase (adh) have been used as a model for studies of ethanol elimination catalysed by non-adh systems like catalase and cytochrome p450. however, in an in vivo study on these animals (adh- deer mice), we detected reversibility in the oxidation of [2h]ethanol, indicating that a major part of the ethanol elimination was due to a dehydrogenase (norsten et al., j biol chem 264: 5593-5597, 1989). in the present investigation, we found ...19938512583
regional analysis of 5-ht1a receptors in two species of peromyscus.two species of deer-mice, peromyscus maniculatus (p. man) and peromyscus leucopus (p. leu), were compared for differences in 5-hydroxytryptamine1a (5-ht1a) receptor number and affinity. both species enter into torpor; however, p. man enters spontaneous torpor with a higher frequency and for a longer duration than p. leu. further, compared to p. leu a higher percentage of p. man exhibit daily torpor. deer mice can be induced to enter torpor by a reduction in food supply, shortened photoperiods, a ...19938516353
hantavirus serologies in patients hospitalized with community-acquired pneumonia.in many patients, the etiology of community-acquired pneumonia is not known but may be caused by previously undescribed pathogens in some cases. the recently identified hantavirus sin nombre (sn) causes hantavirus pulmonary syndrome. because sporadic cases have occurred outside the range of its reservoir (the deer mouse peromyscus maniculatus), an investigation sought to determine whether hantaviruses contributed to cases of community-acquired pneumonia in a large baltimore hospital. acute-phase ...19968537665
larval density and feeding success of ixodes scapularis on two species of peromyscus.one potential mechanism for the regulation of tick populations is density-dependent feeding success on vertebrate hosts. in a series of laboratory experiments, we tested whether the density of larval ixodes scapularis on the mice peromyscus maniculatus and peromyscus leucopus influenced tick feeding success. for both host species, the proportion of ticks feeding to repletion was constant (approximately 40-50%) over a range of infestation from 5 to 100 ticks per mouse. for p. leucopus, neither ma ...19958544056
naturally occurring sin nombre virus genetic reassortants.genetic reassortment has been shown to play an important role in the evolution of several segmented rna viruses and in the epidemiology of associated diseases. sin nombre (sn) virus is the cause of hantavirus pulmonary syndrome throughout the western united states. like other hantaviruses, it possesses a genome consisting of three negative-sense rna segments, s, m, and l. recent analysis has demonstrated the presence of at least three different hantaviruses in nevada and eastern california, incl ...19958553562
effects of bilateral adrenalectomy on initiation of fur growth cycles in the deer mouse (peromyscus maniculatus).the objectives of this study were to determine the effects of bilateral adrenalectomy on the initiation of hair growth in the deer mouse and the duration of the actively growing phase of the hair growth cycle (anagen). bilateral adrenalectomy plus deoxycorticosterone supplementation of adult deer mice resulted in the onset of hair growth 4 days earlier than in sham-operated mice supplemented with deoxycorticosterone. the duration of hair growth (anagen), based on guard hair measurements, was est ...19958569158
sexually dimorphic spatial learning in meadow voles microtus pennsylvanicus and deer mice peromyscus maniculatus.a number of studies examining developmental, neural and hormonal aspects of sexually dimorphic spatial learning (morris water-maze) in meadow voles (microtus pennsylvanicus) and deer mice (peromyscus maniculatus) are described. we found that, in adult deer mice, female spatial performance decreased during the breeding season relative to the non-breeding season, whereas the reverse pattern was observed in male performance. there was a sex difference favouring males in spatial learning during the ...19968576690
hantavirus pulmonary syndrome in florida: association with the newly identified black creek canal virus.hantavirus pulmonary syndrome (hps) is a recently recognized viral zoonosis. the first recognized cases were caused by a newly described hantavirus. sin nombre virus (previously known as muerto canyon virus), isolated from peromyscus maniculatus (deer mouse). we describe a 33-year-old floridian man who resided outside the ecologic range of p maniculatus but was found to have serologic evidence of a hantavirus infection during evaluation of azotemia associated with adult respiratory distress synd ...19968579086
population dynamics of two species of eimeria (apicomplexa: eimeriidae) in deer mice (peromyscus maniculatus): biotic and abiotic factors.i investigated whether biotic factors (competitive exclusion between parasites and host immunity), abiotic factors (high temperature, low temperature, and rainfall), or a combination of the 2 affected the population dynamics of eimeria arizonensis and eimeria delicata in naturally infected deer mice (peromyscus maniculatus). there was no evidence of competitive exclusion between e. arizonensis and e. delicata, nor were e. arizonensis population dynamics affected by host immunity (young deer mice ...19968604087
occurrence of hantavirus within the rodent population of northeastern california and nevada.these studies were initiated to determine the prevalence and hosts of hantaviruses within the rodent population of nevada and northeastern california. a total of 1,867 rodents were collected, sexed, weighed, identified, and tested by enzyme-linked immunosorbent assay for the presence of antibody against hantavirus nucleocapsid. the primary hosts for hantaviruses in this region were found within the family muridae (peromyscus maniculatus. reithrodontomys megalotis. and microtus montanus). studies ...19968619434
copper, zinc, and cadmium concentrations in peromyscus maniculatus sampled near an abandoned copper mineconcentrations of zinc, copper, and cadmium were determined in soil and liver, kidney, bone and stomach contents of deer mice (peromyscus maniculatus) from two sites near an abandoned mine and one control site, on vancouver island, british columbia, canada. soil concentrations of copper were significantly elevated at the mine and off site vs the reference site. in contrast, there was no difference in soil cadmium and zinc concentrations between the mine and reference site. concentrations of copp ...19968661524
expressed peromyscus maniculatus (pema) mhc class i genes: evolutionary implications and the identification of a gene encoding a qa1-like antigen.to gain insight into the evolution of rodent major histocompatibility complex (mhc) class i genes and identify important (conserved) nonclassical class i (class i b) gene products and residues in these proteins, six peromyscus maniculatus mhc (pema) class i cdna clones were isolated and sequenced. five pema class i cdnas appeared most similar to mouse and rat classical class i (class i a) genes. one exhibited highest similarity to an h2 class i b gene, h2-t23 (encoding the qa1 antigen). phylogen ...19968662082
hantavirus pulmonary syndrome: clinical, diagnostic, and virologic aspects.hantavirus pulmonary syndrome is an acute pneumonitis with a high mortality rate that is caused by a newly recognized hantavirus. four corners virus (also known as muerto canyon virus and sin nombre virus) is enzootic among deer mice (peromyscus maniculatus). incidental transmission to humans can result in a disease characterized by rapidly progressive respiratory insufficiency, diffuse noncardiogenic pulmonary edema, vascular volume contraction with hemoconcentration, lactic acidosis, depressed ...19958668854
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