Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| studies of glial lineage and proliferation in vitro using an early marker for committed oligodendrocytes. | the potential of immature glial cells to differentiate into astrocytes (ass) or oligodendrocytes (ols) has been examined using a monoclonal antibody (007) that is specific for ols in vivo. cells were dissociated from 2-day postnatal mouse cortex and labeled with the 007 antibody 2 hr after plating. the cells which were labeled during this single, brief exposure to the antibody retained the antibody on their surfaces over the course of the experiments. cells were double stained at various timepoi ... | 1991 | 1798055 |
| a case of citrullinemia with abnormal messenger rna for argininosuccinate synthetase. | a male neonate, thus far healthy and fed with breast milk, developed rapidly increasing apathy on the third day of life. sucking became poor and hyperhidrosis was present. hyperammonemia (3,305 micrograms/dl) was noted. he became comatose and died on the fourth day. there was a profound derangement of amino acid concentration in the body fluids, with highly elevated citrulline levels (4.70 mumols/ml in serum and 8.47 mumols/ml in urine). autopsy showed diffuse pulmonary bleeding, as the only not ... | 1991 | 1799125 |
| [hematologic parameters of the white donkeys of asinara]. | in 14 albino donkeys (6 males and 8 females) aged 1-12 years, about 25% of the whole population, 30 blood parameters were determined, with automatic equipment, monthly, for 4 months. no significant differences between sexes or compared with other donkey breeds were found, in spite of the particular characteristics of the population and of their environment. | 1991 | 1804239 |
| studies on the ascorbic acid 2-sulfate biosynthesis in rat. | the possible biosynthesis of ascorbic acid 2-sulfate (ass) in rat was investigated. a in vivo test was conducted according to mumma and mohamram. 10 mumoles ascorbic acid (asa) and 25 mu ci35so4(2-) were injected intraperitoneally into rats once a day for four days. 24 hours after the final administration, the animals were sacrificed and the liver, kidneys and urine were collected. the result did not confirm the biosynthesis of ass under the test conditions, though there appeared the possibility ... | 1991 | 1806537 |
| morphological examination of epididymal epithelium in the mule (e. hinnus) in comparison with parental species (e. asinus and e. caballus). | following previous studies about the ultrastructure of male genital tract in parental species, a comparative study of epididymis of one of the possible hybrids, the mule, has been undertaken. apart from small differences, general features of epididymal epithelium in the mule are similar to those of parental species. however, extension of our studies from the donkey to the horse to the hybrid permits a deeper insight into the morphology of this tract of excurrent duct. in the meantime, it is poss ... | 1991 | 1810531 |
| division of astroblasts and oligodendroblasts in postnatal rodent brain: evidence for separate astrocyte and oligodendrocyte lineages. | what precursor cells are the source of the macroglia generated during postnatal development? in order to answer this question, we studied the expression of glial specific antigens in proliferating neuroglia in postnatal rodent brain and optic nerve. immunocytochemistry using antibodies to oligodendrocyte (ol) specific markers (sulfatide and galactocerebroside) and an astrocyte (as) specific marker (glial fibrillary acidic protein) was combined with thymidine autoradiography. during the first wee ... | 1991 | 1827776 |
| donkey and horse alpha 1 b-glycoprotein: partial characterization and new alleles. | 1. the donkey postalbumin protein has been shown to be the equivalent of human alpha 1 b-glycoprotein by protein immunoblotting and n-terminal amino acid sequence. 2. the horse a1b system (already identified as the homologue of human alpha 1 b-glycoprotein) and the donkey alpha 1 b-glycoprotein were characterized further for terminal sialic acid content, isoelectric point, amino acid composition and affinity for the dye-ligand, cibacron blue f3ga (known to bind human alpha 1 b-glycoprotein). 3. ... | 1991 | 1868686 |
| [analytical studies on amino acids and trace elements in donkey-hide gelatin]. | this paper reports the contents of amino acids in donkey-hide gelatin made in different pharmaceutical factories before and after processing. an analytical comparison of trace elements in the gelatin is also presented. | 1991 | 1872968 |
| venezuelan equine encephalomyelitis virus infection in and transmission by the tick amblyomma cajennense (arachnida: ixodidae). | to assess a possible role of ticks as the maintenance host for epizootic strains of venezuelan equine encephalomyelitis (vee) virus, laboratory experiments were conducted to determine if ticks could become infected, maintain, and transmit the virus. larval and nymphal amblyomma cajennense (f.) and larval dermacentor nitens neumann ticks were exposed to epizootic vee virus (trinidad donkey strain) by allowing them to feed on viremic guinea pigs (strain 13). in a. cajennense, transstadial transmis ... | 1991 | 1875367 |
| circadian and seasonal rhythms of melatonin production in mules (equus asinus x equus caballus). | the present study describes the patterns of melatonin production in the mule (equus asinus x equus caballus). blood was sampled hourly for 24 h from eight mule mares in spring and fall. the data obtained show the presence of a circadian rhythm of production of melatonin, with highest values during the dark phase both in spring and fall. in fall the nightly rise of melatonin production begins earlier in the dark phase and reaches higher quantitative levels than in spring. the morning decline of m ... | 1991 | 1880708 |
| allosteric modifier and substrate binding of donkey deoxycytidylate aminohydrolase (ec 3.5.4.12) | the hexameric allosteric enzyme deoxycytidylate aminohydrolase from donkey spleen is shown by equilibrium dialysis to bind specifically the allosteric inhibitor, dttp, the activator dctp, and the substrate analog damp each at six sites (the dttp and dctp sites may or may not be identical). these conclusions contrast with earlier ones that there were four sites for each effector; reasons for the discrepancy are discussed. with the knowledge of site numbers and the kinetic information from the acc ... | 1991 | 1898061 |
| antibodies in horses, mules and donkeys following monovalent vaccination against african horse sickness. | a total of 256 sera collected from three species of domesticated equidae in four different spanish provinces were examined 1-4 months after the administration of attenuated monovalent african horse sickness virus (ahsv) serotype 4 vaccine. approximately 10% of the sera were negative by elisa, virus neutralization, agar gel immuno-diffusion and complement fixation tests. similar negative reactions were recorded with sera from two ponies after experimental primary vaccination. the rapid rise in an ... | 1991 | 1902185 |
| zebra chorionic gonadotropin: partial purification and characterization. | six samples of pregnant zebra (z) serum from the first and second trimesters of pregnancy were analyzed by ria and shown to have chorionic gonadotropin levels comparable to that of the mare (0.9-5.3 micrograms/ml); first trimester levels in most cases were higher than second trimester levels. a pool of the sera (10 ml) was fractionated by methods previously employed for the purification of equine (e) and donkey (d) chorionic gonadotropin to achieve a concentration of the zebra chorionic gonadotr ... | 1991 | 1907860 |
| a single amino acid change in the e2 glycoprotein of venezuelan equine encephalitis virus affects replication and dissemination in aedes aegypti mosquitoes. | four monoclonal antibody-resistant variants (marvs) of venezuelan equine encephalitis (vee) virus were used to study mosquito-virus interactions. in vitro experiments using an aedes albopictus cell line, c6/36, demonstrated that an amino acid change in the glycoprotein e2h epitope (marv 1a3b-7) decreased virus growth when compared with the wild-type, trinidad donkey virus, and its vaccine derivative, tc-83. the marvs replicated as efficiently as the parent virus when inoculated into aedes aegypt ... | 1991 | 1919525 |
| oestrogen production by the preimplantation donkey conceptus compared with that of the horse and the effect of between-species embryo transfer. | aromatase distribution in membranes of preimplantation horse and donkey conceptuses was compared by measuring the incorporation of [3h]androstenedione into oestrone and oestradiol-17 beta. in the donkey conceptus, aromatase activity was similar in all the tissues examined (yolk sac, chorionic girdle and allantochorion), whereas in the horse it was generally lower and showed the relationship chorionic girdle greater than yolk sac greater than allantochorion. a higher proportion of labelled precur ... | 1991 | 1920283 |
| piromyces rhizinflata nov. sp., a strictly anaerobic fungus from faeces of the saharian ass: a morphological, metabolic and ultrastructural study. | a new species of strictly anaerobic chytridiomycete was isolated from dried faeces of the saharian ass that had been stored for up to 150 days. because of its monocentric thallus and uniflagellate zoospores it belongs to the genus piromyces. it exhibits a high affinity for p. mae and p. dumbonica but differs from them in its morphological and ultrastructural characteristics. its flagellar apparatus is similar to that of all previously reported fungi. | 1991 | 1936931 |
| [motor activity of the point of the tongue in forming dento-alveolar consonants]. | electromagnetic articulography, a new tool for the study of articulatory movements, was used for the examination of apical tongue dorsum movements during the production of repeated vcv sequences. in our study of 16 normal german speakers, the trajectories of three apicolingual consonants, /t/, /s/ and /ss/, in an aca sequence were assessed for inclination and length of the articulatory movement trajectories. a clear differentiation in length and direction of articulatory movements for the vcv ut ... | 1991 | 1937297 |
| immunohistochemistry of amyloid-related neuropathies. | studying eight sural nerve biopsy specimens of a biopsied trigeminal ganglions and peripheral nerves from eight autopsies, some of them retrieved 30 years ago, with a panel of antibodies against several types of amyloid revealed the presence of af, al of the lambda type, aa and ass in peripheral nerve specimens while ab, ae, asc, asb, acc, aprp could not be detected. amyloid of the af type in the endoneurial space was associated with loss of unmyelinated and small caliber myelinated axons. avail ... | 1991 | 1959254 |
| intake, digestion and gastrointestinal transit time in resting donkeys and ponies and exercised donkeys given ad libitum hay and straw diets. | four donkeys and four ponies maintained in climate rooms, were provided with meadow hay or barley straw supplemented with minerals and vitamins ad libitum. both diets were given to all animals for periods of 21 days. measurements were made during the last seven days following single doses of two non-absorbable markers (cr-fibre and co-edta). after six weeks the donkeys repeated the trial, walking 14 km and ascending 260 m five days per week. at rest ponies ate more than donkeys, however the donk ... | 1991 | 1959523 |
| studies of the acute phase response in experimental serum sickness. | the acute phase behavior of c-reactive protein (c-rp), the third component of complement (c3) and total haemolytic complement activity was studied during the course of acute serum sickness (ass) in rabbits. the specific aim was to establish whether the induction protocol caused a significant change in the serum concentration of proteins (such as c3) which could modify the outcome of the disease. ass was induced by an intravenous (iv) bolus of bovine serum albumin (250 mg/kg) with or without prio ... | 1990 | 1966987 |
| a molecular genetic linkage map of mouse chromosome 2. | interspecific backcross mice were used to create a molecular genetic linkage map of chromosome 2. genomic dnas from n2 progeny were subjected to southern blot analysis using molecular probes that identified the abl, acra, ass, c5, cas-1, fshb, gcg, hox-5.1, jgf-1, kras-3, ltk, pax-1, prn-p, and spna-2 loci; these loci were added to the 11 loci previously mapped to the distal region of chromosome 2 in the same interspecific backcross to generate a composite multilocus linkage map. several loci ma ... | 1990 | 1970329 |
| assignment of the structural gene for argininosuccinate synthetase to proximal mouse chromosome 2. | in order to develop linkage markers for the murine argininosuccinate synthetase locus (ass-1), we have searched for restriction fragment length polymorphisms in the mouse genome using cloned sequences from the mouse arginosuccinate synthetase structural gene. five restriction fragment length polymorphisms were found among the recombinant inbred progenitor strains akr/j, balb/cbyj, c3h/hej, c57bl/6j, c57l/j, dba/2j, and swr/j. of these, four polymorphisms were found to distinguish the swr/j strai ... | 1990 | 1970331 |
| identification of a highly polymorphic microsatellite vntr within the argininosuccinate synthetase locus: exclusion of the dystonia gene on 9q32-34 as the cause of dopa-responsive dystonia in a large kindred. | dopa-responsive dystonia is a clinical variant of idiopathic torsion dystonia that is distinguished from other forms of dystonia by the frequent occurrence of parkinsonism, diurnal fluctuation of symptoms, and its dramatic therapeutic response to l-dopa. linkage of a gene causing classic dystonia in a large non-jewish kindred (dyt1) and in a group of ashkenazi jewish families, to the gelsolin (gsn) and arginino-succinate synthetase (ass) loci on chromosome 9q32-34, respectively, was recently det ... | 1991 | 1985454 |
| equine chorionic gonadotropin. | cells from the chorionic girdle of the equine trophoblast invade the maternal endometrium at day 36 of gestation and become established as secretory elements known as the endometrial cups. these structures, which persist for 40-60 days, produce a gonadotropin which can be found in circulation until about day 130 of gestation. this glycoprotein has been identified in the horse and the donkey, with the former having received much better characterization. it consists of 2 noncovalently linked pepti ... | 1991 | 2026120 |
| transmission of venezuelan equine encephalomyelitis virus by strains of aedes albopictus (diptera: culicidae) collected in north and south america. | experimental studies were undertaken to ascertain the vector potential of north american (houston and alsace) and south american (sao paulo and santa teresa) strains of aedes albopictus (skuse) for an epizootic (trinidad donkey) strain of venezuelan equine encephalomyelitis (vee) virus. infection rates were similar in all four strains of ae. albopictus tested after ingestion of vee virus from a viremic hamster. virus disseminated from the midgut to the hemocoel in about 80% of infected mosquitoe ... | 1991 | 2033608 |
| use of a new synthetic-peptide-derived monoclonal antibody to differentiate between vaccine and wild-type venezuelan equine encephalomyelitis viruses. | we have prepared a murine monoclonal antibody (mab) capable of distinguishing between wild-type venezuelan equine encephalomyelitis (vee) virus and the tc-83 vaccine derivative. this mab, 1a2b-10, was derived from immunization with a synthetic peptide corresponding to the first 19 amino acids of the e2 glycoprotein of trinidad donkey vee virus. the mab reacts with prototype viruses from all naturally occurring vee subtypes except subtype 6 in an enzyme-linked immunosorbent assay. it does not rea ... | 1991 | 2037683 |
| syntenic conservation between humans and cattle. i. human chromosome 9. | bovine x hamster hybrid somatic cells have been used to investigate the syntenic relationship of nine loci in the bovine that have homologous loci on human chromosome 9. six loci, aldh1, aldob, c5, ggtb2, gsn, and itil, were assigned to the previously identified bovine syntenic group u18 represented by aco1, whereas the other three loci, abl, ass, and grp78, mapped to a new, previously unidentified autosomal syntenic group. additionally, a secondary locus, abll, which cross-hybridized with the a ... | 1990 | 2081596 |
| chromosomal and molecular evolution in asiatic wild asses. | chromosomal studies of tibetan wild ass, equus kiang holdereri are reported for the first time. a robertsonian polymorphism resulting in diploid numbers of 2n = 51 and 2n = 52 was identified. this polymorphism involves the same elements that participate in the polymorphic robertsonian rearrangement producing diploid numbers of 54-56 in e. hemionus kulan and e. hemionus onager. comparison of mitochondrial dna restriction fragment patterns among three unrelated kiang individuals and between kiangs ... | 1990 | 2090563 |
| mycoplasmas from donkeys and horses in the sudan. | seventeen isolates (4.27%) were recovered from 398 samples. twelve isolates (4%) were obtained from 300 donkey nasal swabs, three (4.3%) and two (6.89%) isolates were recovered from 69 horse nasal swabs and 29 mare uterine washings, respectively. nine isolates were lost during storage at -20 degrees c and the remaining eight were identified as mycoplasmas and their biological, biochemical and serological reactions were investigated. the isolates could be divided into two groups on the basis of g ... | 1990 | 2103053 |
| [antimicrobial action of a repin bandage in periodontology]. | the paper deals with the antimicrobial activity of repin bandages used commonly in periodontology. the main criterium for evaluation was the number of bacteria in the wound beneath the bandage, ass ossessed by cultivation. the authors compared three types of bandages (repin with traumacel, repin with framykoin and repin alone). repin with framykoin reduced most effectively the number of micro-organisms for the longest period of time. the results revealed that the amount of bacteriabacteria benea ... | 1990 | 2103618 |
| elephant pituitary gonadotropins. | we describe for the first time the purification and some properties of luteinizing hormone (lh) and follicle-stimulating hormone (fsh) isolated from anterior pituitary tissue of the african elephant (loxodonta africana). methodology previously applied to equine and donkey pituitaries was used to obtain purified preparations of elephant lh and fsh in yields of 8.8 and 0.48 mg, respectively, per 10 g pituitary powder. the preparations were characterized by hplc gel filtration and amino acid analys ... | 1990 | 2118115 |
| measurement systems and indices of miners' exposure to radon daughter products in the air of mines. | this paper presents the classification of measurement systems that may be used for the assessment of miners' exposure to radiation in mines. the following systems were described and characterized as the air sampling system (ass), the environmental control system (ecs), the individual dosimetry system (ids), the stream monitoring system (sms) and the exhaust monitoring system (ems). the indices for evaluation of miners' working environments, or for assessment of individual or collective miners' e ... | 1990 | 2134320 |
| cutaneous habronemiasis in horses and domestic donkeys (equus asinus asinus). | cutaneous habronemiasis in 15 horses and 5 donkeys is described. the lesions were distributed in many parts of the body involving the medial canthus, shoulder and pectoral regions, knee and fetlock joints, abdominal wall and prepuce. some animals had more than one lesion. the lesions were ulcerative and filled with soft light red granulation tissue. when curretted, the deeper layers revealed a dense fibrous tissue with calcified foci. close examination of the lesions showed that the superficial ... | 1990 | 2145616 |
| [characteristics of lateralization in rats prone to audiogenic epilepsy]. | differences in asymmetry of audiogenic seizure susceptible rats (ass) as compared with resistant rats (asr) were analysed in the present study. it was found that ass rats were more lateralized in behavioral tests (the choice of one side of t-maze and the preference of one paw in obtaining food from the tube) and after systemically injected apomorphin. it was also established that there were more sexual differences of asymmetry in the ass group than in the asr one. | 1990 | 2162590 |
| comparative studies of the proteins of equine herpesviruses 4 and 1 and asinine herpesvirus 3: antibody response of the natural hosts. | proteins of purified virions of equine herpesvirus 4 (ehv-4; equine rhinopneumonitis), ehv-1 (equine abortion virus) and asinine herpesvirus 3 (ahv-3) were compared by metabolic labelling with [35s]methionine or [14c]glucosamine during growth of low passage virus in natural host cells (horse or donkey) and high passage virus in an appropriate cell line and analysis by sds-page. approximately 25 different proteins (mr 300k to 21.5k) were clearly resolved for each virus. the three viruses had simi ... | 1990 | 2170572 |
| [stomach tolerance of buffered and unbuffered low-dose acetylsalicylic acid: an endoscopy controlled double-blind study in volunteers]. | in this randomised double-blind cross-over study the gastroduodenal tolerability of buffered acetylsalicylic acid (ass) (aspalox = 325 mg ass plus 300 mg magnesium aluminium hydroxide) daily has been compared with unbuffered ass (325 mg) daily in 12 healthy volunteers using upper gl-endoscopy. the treatment period lasted 14 days: endoscopic controls were performed at entry and repeated at day 14. at day 0 the mean endoscopic score averaged 0.8 +/- 0.1 in both groups (mw +/- sem). one tablet aspa ... | 1990 | 2188449 |
| [prevention of thromboembolism in para-articular femoral fractures of the hip--results of a prospective randomized study of heparin-dhe and ass-dhe]. | the effectiveness of prophylaxis of thromboembolism either by acetyl-salicylic-acid (asa) 0.5 g + dihydroergotamin (dhe) 2.5 mg three times a day or by heparin 5000 iu + 0.5 mg dhe (hdhe) three times a day was compared in 404 patients, elder than 55 years, with fractures close by the hip joint. effectiveness was proved daily clinical controls, perfusion scintigraphy on the day after admission, the fourth postoperative day and the day before discharge and by autopsy of the died patients. clinical ... | 1990 | 2200187 |
| a comparison between the digestibility of hay by donkeys and ponies. | 1990 | 2206326 | |
| disposition of oxytetracycline in horses, ponies and donkeys after intravenous administration. | 1990 | 2209525 | |
| the median cleft of the lower lip and mandible and its surgical correction in a donkey. | 1990 | 2209530 | |
| dystocia attributable to a fetal monster resembling schistosomus reflexus in a donkey. | a schistosomus reflexus fetal monster was removed from a jenny via cesarean section. this type of anomaly is seen principally in ruminants and swine. only 3 cases have been reported in equidae. | 1990 | 2211309 |
| time course of adaptation and recovery from adaptation in the cat auditory-nerve neurophonic. | the auditory-nerve neurophonic (ann) reflects the ensemble response of phase-locked firing in single auditory-nerve fibers to sustained signals. consequently, neural response properties such as adaptation and recovery from adaptation can be observed. in this study, ann responses to 800-hz, 100-ms tones presented at 10-30-db sl were recorded using bipolar platinum-iridium electrodes placed on the auditory nerve of the cat. the cat ann adaptation properties were determined and fit to the equation: ... | 1990 | 2212311 |
| serum thromboxane generation by platelets in several domestic animal species. | blood collected from calves, sheep, goats, pigs, dogs, horses, ponies and donkeys, was allowed to clot under standard conditions. thromboxane b2 generated during the clotting process was measured by radioimmunoassay in serum harvested from each sample. highly significant differences were found between species and also between genera within a species. highest concentrations of thromboxane b2 were detected in the dog samples (887.7 +/- 123.7 ng/ml) and lowest concentrations in samples from sheep ( ... | 1990 | 2224484 |
| 'donkeys' and dinner duty. | 2016 | 2235603 | |
| [experiences from general practice: use of acetylsalicylic acid and anticoagulants in patients following acute myocardial infarct]. | an effective therapy with coumarin derivatives within the secondary prevention after acute myocardial infarction makes great demands on the dispensary care. the risk of serious complications is relatively high. the risk of therapy with acetyl salicylic acid (ass) in low dosage is significantly smaller. a significant decrease of the rate of reinfarctions and lethality by acetyl salicylic acid was made evident. the retrospective evaluation of the duration of treatment and effectiveness of the ther ... | 1990 | 2247990 |
| [the sportmed commission of the ass (swiss sports association)]. | 1990 | 2255887 | |
| elevated argininosuccinate synthetase activity in adult t leukemia cell lines. | argininosuccinate synthetase (ass) is a atp-dependent and rate-limiting enzyme of the urea cycle which catalyzes l-citrulline to l-arginine in combination with argininosuccinate lyase (asl). we demonstrate here that (a) human normal t and b lymphocytes did not express ass activity, (b) however, three adult t leukemia (atl) cell lines tested here exhibited significant elevation of ass activity, and (c) asl activity remained relatively constant in normal lymphocytes and various leukemia cell lines ... | 1990 | 2259230 |
| ca repeat polymorphism at the ass locus. | 1990 | 2259653 | |
| pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia. | oculomotor functioning of 26 probands with schizophrenia, 12 spectrum and 46 nonspectrum first-degree relatives, and 38 nonpsychiatric control subjects was evaluated. spectrum relatives had more anticipatory saccades (ass) and lower pursuit gain than nonspectrum relatives, who had more ass and lower pursuit gain than control subjects. probands also had lower pursuit gain than nonspectrum relatives and control subjects but did not differ from other groups on as frequency. control subjects had mor ... | 1990 | 2266205 |
| suspected congenital origin of bilateral hydrosalpinx in a jenny donkey. | 1990 | 2269270 | |
| differential cellular localization of enzymes of l-arginine metabolism in the rat brain. | polyclonal rabbit antisera specific to argininosuccinate synthetase (ass), argininosuccinate lyase and arginase revealed that these enzymes of l-arginine metabolism are generally localized in different cells of the rat brain. in the main olfactory bulb and the cerebellar cortex the three immunoreactivities were localized in different cells: in the somatic motor nuclei ass-like immunoreactivity was localized in incoming fibers, and the other two enzymes were found in the motor neurons. the result ... | 1990 | 2271938 |
| an investigation of the relationships between body condition and plasma lipid and lipoprotein concentrations in 24 donkeys. | obese donkeys are susceptible to a hyperlipaemic crisis characterised by high plasma triglyceride concentrations. in this study, the relationships between the body condition of 24 donkeys and their basal lipid metabolism were investigated. plasma cholesterol, triglyceride and lipoprotein cholesterol concentrations were measured in healthy donkeys classified according to their body condition as thin, ideal or obese. there were significant differences between the groups in the concentrations of tr ... | 2007 | 2275089 |
| covalent structure of the minor monomeric beta-lactoglobulin ii component from donkey milk. | the complete primary structure of the minor beta-lactoglobulin ii component from donkey milk is presented. it has been established by amino-acid sequencing and mass-spectrometry analysis of intact protein and peptides obtained after enzymatic and chemical cleavages. the molecular mass and the pi of the protein are calculated to be 18,261 da and 4.5 respectively. despite the close structural similarity of the donkey and horse major beta-lactoglobulin i components, their minor beta-lactoglobulin i ... | 1990 | 2291812 |
| probable paratuberculosis in a sicilian ass. | a presumptive diagnosis of paratuberculosis was made in a sicilian ass on the basis of a history of chronic diarrhea and weight loss, pasture exposure to a heifer with paratuberculosis confirmed by bacterial culture of feces, postmortem identification of granulomatous inflammation of the intestine containing acid-fast organisms, the absence of acid-fast organisms in extraenteric tissues, and the absence of exposure to tuberculosis. the literature on paratuberculosis in equids is reviewed. the po ... | 1990 | 2298679 |
| blood lead and zinc protoporphyrin levels in donkeys and mules near a secondary lead smelter in jamaica, 1987-88. | during the course of an investigation into community lead poisoning near a secondary lead smelter in jamaica, blood lead and zinc protoporphyrin levels were measured in 8 exposed and 6 (3 jamaican, 3 us) unexposed donkeys and mules. the blood lead levels of 6 animals in the contaminated area ranged from 7.5 to 33 micrograms/dl (mean = 17.6 micrograms/dl), compared to 1.8 and 2.4 in unexposed jamaican animals. more striking was the difference in zinc protoporphyrin levels; all 8 exposed donkeys a ... | 1990 | 2301150 |
| reference ranges and the influence of age and sex on hematologic and serum biochemical values in donkeys (equus asinus). | hematologic and serum biochemical values were determined in blood samples from 217 donkeys (equus asinus). donkeys were classified on the basis of size, sex, age, and whether they were domestic or feral. parametric (mean +/- 2 sd) and nonparametric (2.5th to 97.5th percentile) reference ranges were calculated for each analyte. for all donkeys, 26 of 46 analytes significantly departed from gaussian distribution. serum lactate dehydrogenase activity in miniature donkeys was higher than that in oth ... | 1990 | 2316919 |
| dystonia gene in ashkenazi jewish population is located on chromosome 9q32-34. | idiopathic torsion dystonia (itd) is a neurological disorder characterized by sustained muscle contractions that appear as twisting movements of the limbs, trunk, and/or neck, which can progress to abnormal postures. most familial forms of itd follow autosomal dominant transmission with reduced penetrance. the frequency of itd in the ashkenazi jewish population is five to ten times greater than that in other groups. recently, a gene for itd (dyt1) in a non-jewish kindred was located on chromosom ... | 1990 | 2317008 |
| zoonotic cutaneous leishmaniasis due to leishmania (viannia) braziliensis associated with domestic animals in venezuela and brazil. | after outbreaks of cutaneous leishmaniasis in solano state, venezuela, 5% of the population had parasitized ulcers while after similar outbreaks in mesquita, rio de janeiro state, brazil, 9% had the disease. in these foci children, including some under six years of age, were affected. there was no significant difference in the occurrence of the disease according to sex or type of employment. in solano, 3% of dogs and 28% of donkeys had parasitized lesions, while in mesquita these indices were 19 ... | 1989 | 2319948 |
| an immunohistochemical study of various peptide-containing endocrine cells and neurones at the equine ileocaecal junction. | the ileocaecal junctions of 5 horses and 2 donkeys were examined by using antisera to the following peptides: somatostatin, glucagon, gastrin, neurotensin, vasoactive intestinal peptide (vip), peptide histidine isoleucine (phi), calcitonin gene-related peptide (cgrp), substance p (sp) and neuropeptide y (npy). antisera to somatostatin, neurotensin and npy demonstrated endocrine cells in the ileal- and caecal parts of the ileocaecal junction, while immunoreactivity for glucagon was demonstrated i ... | 1990 | 2338994 |
| scanning electron and light microscopy of the mucosa of the equine ileocaecal junction. | the ileocaecal junction mucosal surface morphology of 5 horses and 1 donkey was examined using scanning electron microscopy and light microscopy. based on differences in surface morphology, the junction could be divided into 4 distinct regions. the distal extremity of the ileum was characterized by the presence of typical finger-like villi followed by a narrow zone displaying short, stubby villi which gradually merged into a 3rd region representing the true transitional zone between the small an ... | 1990 | 2338995 |
| tracheal obstructions in two horses and a donkey. | the clinical signs associated with intramural tracheal obstructions in two horses and a donkey were respiratory distress and coughing, which were aggravated by exercise and excitement. the obstructions were at the level of the thoracic inlet and consisted either of flattening of the cartilage rings in the dorsoventral plane or of cartilage rings having a scroll-like conformation. they appeared to be developmental in origin and to have been present for a considerable time before the onset of clin ... | 1990 | 2343517 |
| partial cdna sequence for the donkey chorionic gonadotrophin-beta subunit suggests evolution from an ancestral lh-beta gene. | a 246 bp cdna clone representing the c-terminal region of the donkey (equus asinus) chorionic gonadotrophin (cg)-beta subunit was isolated from a placental library. the transcript contained the 3' untranslated region and 42% of the cg-beta subunit coding region (amino acid residues 85-146 of the mature peptide). comparison of the deduced donkey amino acid sequence with the published horse cg-beta subunit protein sequence (where they overlapped) revealed an overall homology of 61%. however, most ... | 1990 | 2344391 |
| [left-ventricular bypass: characteristics of homeostasis]. | experiments were conducted on donkeys to study the peculiarities of homeostasis in establishment of left ventricular bypass (lvb) by means of an artificial heart ventricle (ahv). preliminary modelling of acute cardiac insufficiency makes the work of the ahv effective and ensures longer survival than that among intact animals. however, arterial hypertension and anemia accompanying prolonged work of the ahv and resulting from the interaction of the last named with the cardiovascular system sharply ... | 1990 | 2357402 |
| [is sodium salicylate suitable as a protective agent in the analgesic-induced asthma syndrome?]. | the protective effect of nas in analgetic-induced asthma (aia) was investigated in patients with aia. in none of the patients was the asthmatic reaction to acetylsalicylic acid (ass) completely inhibited by the oral administration of nas. in a single patient, an intolerance reaction occurred after oral ingestion of the substance. in several patients, induction of tolerance towards acetylsalicyclic acid was facilitated after prior ingestion of nas. | 1990 | 2367419 |
| [the patient following ptca]. | diagnostic measures after ptca consist of history, clinical findings, after 3 months and thereafter in 6 months intervals as well as ergometry in case of recurrency of complaints of after 3 months and then in 6 months intervals. a thallium-scintigraphy is done eventually. a repetition of a coronarography is indicated only in cases of typical symptoms or registration of ischemia. therapy consists of lifelong ass and calcium channel blockers for 3 months and treatment of risk-factors. repetition o ... | 1990 | 2368418 |
| [risk profile and macroangiopathy in type ii diabetics in medical practice]. | the risk profile and the macro-vascular complications of patients with type ii diabetes mellitus (niddm) was investigated in general practice patients for the first time in the frg. it was the aim of the study to evaluate the efficacy of the therapy and possible improvements after detailed instructions in a random sample of well defined niddm in the greater munich area. 290 niddm (187 female, 103 male) out of a total of 1500 patients treated by 22 general practitioners were randomly recruited fo ... | 1990 | 2371785 |
| suppression of lymphocyte proliferation by a greater than 30,000 molecular weight factor in horse conceptus-conditioned medium. | in this experiment we have identified and partially characterized the immunosuppressive activity of preimplantation horse conceptus-conditioned medium (hccm). horse conceptuses were nonsurgically flushed from mares at days 9-10 (n = 6), 15-16 (n = 3), and 25-26 (n = 3). after incubating the conceptuses for 24 h in rpmi-1640 supplemented with 15% fetal calf serum (fcs) and 1% penicillin/streptomycin, hccm was obtained from cultures and tested for immunosuppressive activity in lymphocyte prolifera ... | 1990 | 2378942 |
| cystic echinococcosis in the xinjiang/uygur autonomous region, people's republic of china. i. demographic and epidemiologic data. | demographic and epidemiologic data on those factors potentially related to the prevalence and transmission of hydatid disease caused by echinococcus granulosus were collected in 1987 from each household in 85 villages in the two communities of yuanhucun and ershilidian within hutubi county in the xinjiang/uygur autonomous region, prc, with additional questionnaire data collected from approximately 40 households randomly selected from each of 16 villages within those communities. yuanhucun and er ... | 1990 | 2382094 |
| [gastrointestinal tolerance of 30 mg versus 300 mg acetylsalicylic acid daily. an endoscopically controlled double-blind study of healthy subjects]. | acetylsalicylic acid (ass) is increasingly used in the prevention of cardiovascular diseases. in recent years daily ass-doses (100 to 300 mg) have been given for this indication. studies with still lower ass-doses (f. i. 30 mg daily) are the focus of ongoing clinical trials. in a randomized double-blind study we have evaluated the gastroduodenal tolerability of 30 mg ass and 300 mg ass daily in 20 healthy volunteers using upper gi-endoscopy. both ass-dosages have been taken for a period of four ... | 1990 | 2385209 |
| role of complement and the fc portion of immunoglobulin g in immunity to venezuelan equine encephalomyelitis virus infection with glycoprotein-specific monoclonal antibodies. | we have previously characterized with monoclonal antibodies (mabs) seven unique epitopes on the two envelope glycoproteins of venezuelan equine encephalomyelitis (vee) virus vaccine strain tc-83. the epitopes important in protection from vee virus infection were determined in passive antibody transfer studies, with virulent vee (trinidad donkey) virus as the challenge virus. selected high-avidity mabs to the three major protective epitopes (e2c, e1b, and e1d) were assayed for in vitro complement ... | 1985 | 2410632 |
| the isoelectric focusing of keratins in hair followed by silver staining. | an isoelectric focusing method followed by silver staining has been developed for the study of keratins which is as effective as two-dimensional electrophoresis and fluorography for hair species identification. hair from dogs, rabbits, horses, cows, guinea-pigs, donkeys, sheep and cats were successfully identified. narrow ph ranges were used to observe heterogeneity in human hair. although this heterogeneity may be affected by environmental conditions, it may be of use in criminalistics. | 1985 | 2416657 |
| effect of somatocrinin and a somatostatin antiserum on liver growth in the rat. | this study examines the effects of somatocrinin (grf) and somatostatin antiserum (ass) alone, and in combination, on liver growth. twenty-four-day-old rats were injected s.c. twice daily for 14 days with either saline or grf (4 and 20 micrograms x kg-1). ass was given i.p. every 2 days. grf alone had no effect on liver weight, but produced hyperplasia and increased rna content. ass alone had no effect on rna, dna, and protein contents. potentiation of the effects of grf by ass was observed on li ... | 1987 | 2432209 |
| effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat. | this study examines the effects of somatocrinin (grf) and somatostatin antiserum (ass), jointly and separately on gastric and duodenal growth. 24-day-old rats received twice daily sc injections of saline or grf (4 and 20 micrograms x kg-1) for 14 days. ass was given ip every 2 days. alone, grf increased gastric fundus weight concomitantly with dna, rna and protein contents producing hyperplasia and hypertrophy within this gland. alone, ass increased rna and protein cellular concentrations. joint ... | 1986 | 2433713 |
| effect of somatocrinin with or without a somatostatin antiserum on pancreatic growth. | the current study examines the effects of somatocrinin (grf) and somatostatin antiserum (ass) alone and in combination on pancreatic growth. twenty-four-day-old rats were injected daily s.c. at 10:00 and 16:30 h for 14 days with either saline or grf (4 and 20 micrograms x kg-1). ass was given i.p. every other day. pancreatic weights and dna, rna, protein, amylase, and chymotrypsin total contents and concentrations were evaluated at the end of treatment. grf alone was associated with significant ... | 1986 | 2437558 |
| abnormal expression of surface immunoglobulin isotypes on antigen-binding b lymphocytes from mice tolerant to trinitrophenyl determinants. | temporary b-cell tolerance to the trinitrophenyl (tnp) hapten can be produced in bdf1 mice by intraperitoneal injection of trinitrobenzene sulfonic acid (tnbs). antigen-binding cells (abc) specific to tnp, measured as tnp donkey erythrocyte rosettes, are found in tolerant mice as well as in immune mice. we have studied the surface immunoglobulin isotype profile of these tnp-binding lymphocytes (tnp-abc) in four groups of animals: nonimmune, immune, tolerant, and tolerant-challenged. immune mice ... | 1987 | 2439212 |
| [the proteolytic pretreatment of formalin-fixed tissue in immunohistochemical diagnosis]. | proteolytic enzymes were tested for improving histochemical localization of tissue antigens. sections, 2-4 micron in thickness, were prepared on sodium-silicate coated slides from formalin-fixed, paraffin-embedded human biopsies. a modification of the sternberger technique (pap) and the indirect immunofluorescence method were used for the localization of 15 various antigens: heavy chain immunoglobulins, light chain immunoglobulins, alpha 1-fetoprotein, alpha 1-antichymotrypsin, myoglobin, fibron ... | 1988 | 2458612 |
| recombinant vaccinia/venezuelan equine encephalitis (vee) virus expresses vee structural proteins. | cdna molecules encoding the structural proteins of the virulent trinidad donkey and the tc-83 vaccine strains of venezuelan equine encephalitis (vee) virus were inserted under control of the vaccinia virus 7.5k promoter into the thymidine kinase gene of vaccinia virus. synthesis of the capsid protein and glycoproteins e2 and e1 of vee virus was demonstrated by immunoblotting of lysates of cv-1 cells infected with recombinant vaccinia/vee viruses. vee glycoproteins were detected in recombinant vi ... | 1988 | 2462013 |
| field monitoring versus individual miner dosimetry of radon daughter products in mines. | the paper presents the results realised simultaneously by two different and independent systems of measurement of an assessment of miners' exposure to radon daughter products which naturally occur in the air of mines. the first one, called the air sampling system (ass), was based on the field monitoring of radon progeny in air, the second one, called the individual dosimetry system (ids), was based on the individual dosimeters worn by miners. experimental comparison of these two systems has been ... | 1989 | 2489420 |
| baermannization of dictyocaulus spp. from faeces of cattle, sheep and donkeys. | faeces were collected per rectum from calves infected with dictyocaulus viviparus (d.v.), from lambs infected with dictyocaulus filaria (d.f.) and donkeys infected with dictyocaulus arnfieldi (d.a.). in one experiment, the influence of storage temperature before baermannization was investigated. recovery rate for d.v. was approximately 80% after 24 h at 4 degrees c or 16 degrees c but only 40% at 20 degrees c. after two days at 20 degrees c the rate had fallen to 20%. recovery rates for d.f. dec ... | 1989 | 2523174 |
| the full-length nucleotide sequences of the virulent trinidad donkey strain of venezuelan equine encephalitis virus and its attenuated vaccine derivative, strain tc-83. | nucleotide sequence analysis of cdna clones covering the entire genomes of trinidad donkey (trd) venezuelan equine encephalitis (vee) virus and its vaccine derivative, tc-83, has revealed 11 differences between the genomes of tc-83 virus and its parent. one nucleotide substitution and a single nucleotide deletion occurred in the 5'- and 3'-noncoding regions of the tc-83 genome, respectively. the deduced amino acid sequences of the nonstructural polypeptides of the two viruses differed only in a ... | 1989 | 2524126 |
| critical and controlled tests of activity of a macrocyclic lactone (compound f28249-alpha) against natural infections in internal parasites of equids. | thirteen critical tests (n = 11 horses and 2 ponies) and 4 controlled tests (n = 4 donkeys and 6 horses) were performed to evaluate the activity of the experimental macrocyclic lactone compound f28249-alpha against internal parasites of equids. in the critical tests, activity was determined mainly against the large parasites, but 1 critical test also included benzimidazole-resistant small strongyles. in the controlled tests, evaluation of drug activity included large parasites and stomach worms ... | 1989 | 2527481 |
| an approach to the evaluation and documentation of adverse drug reaction. | this paper reviews an approach to the evaluation and documentation of suspected adverse drug reaction (adr). i propose an algorithm for the evaluation of suspected adr. i recommend that the adverse drug reaction scoring system(ass) or the adverse drug reactions probability scale(aps) be used when evaluating suspected adr. in these two scoring systems, points are allotted according to response to a series of questions on events relating to the clinical manifestations of the suspected adr. dependi ... | 1989 | 2531469 |
| isolation of a/equi-2 virus during 1987 equine influenza epidemic in india. | processing of nasal materials from clinical cases during the 1987 influenza epidemic in northern and central india resulted in the isolation of two haemagglutinating agents; one each from donkeys and horses at bhiwani in haryana state and ludhiana in punjab state, respectively. these were typed as influenza a/equi-2 viruses by haemagglutination inhibition test. the two isolates were designated as a/equi-2/bhiwani/1/87 and a/equi-2/ludhiana/1/87. the bhiwani/87 isolate was confirmed to have h3n8 ... | 1989 | 2550218 |
| multilocus linkage analysis with the human argininosuccinate synthetase gene. | we have identified three restriction fragment length polymorphisms (rflps) from within the argininosuccinate synthetase (ass) gene which maps to human chromosome 9q34-qter. although rflps at pseudogene loci are detected by the cdna, these are the first polymorphisms reported at the ass locus. the three rflps are in linkage equilibrium with each other, and haplotypes for the ass locus are highly informative. two-locus recombination estimates between ass and seven other 9q markers indicated that a ... | 1989 | 2575581 |
| leptospirosis in man, in wild and in domestic animals at waste disposal sites in cairo. | the authors examined 65 rattus rattus, 28 pigs, 12 donkeys, 67 goats, 5 sheep, 1 cow and 1 dog as well as 196 inhabitants at two settlements on the waste disposal sites at the periphery of cairo. rattus norvegicus were positive in 55.4% for l. ictero-haemorrhagiae, pigs in 14.3% for l. pomona and in 3.6% for l. ictero-haemorrhagiae. 2 out of 12 donkeys were positive for l. pomona, 1 of them for l. pyrogenes and l. icterohaemorrhagiae as well, goats in 1.5% for l. grippotyphosa. human sera reacte ... | 1989 | 2583498 |
| [the significance of detecting corynebacterium equi in the conjunctiva of children in cairo]. | the probable correlations between certain corynebacterium are discussed. carpenter et al. (1976) describes a corynebacterium equi-pneumonia in a patient with hodgkin's disease; gardner et. al. (1976) also reports on a case of pneumonia. golub et. al. (1967) demonstrates a lung abscess resulting from corynebacterium equi. williams et. al. (1971) demonstrates a thoracic infection in an immunosuppressed patient. although, our findings have been demonstrated only in conjunctivitis of children, hithe ... | 1989 | 2583507 |
| immunization of equines with phospholipase a2 protects against the lethal effects of crotalus durissus terrificus venom. | equines (2 horses and 2 donkeys) immunized with whole crotalus durissus terrificus venom or its phospholipase a2 component either presented an increased survival time determined 3 days after challenge or were totally resistant to a challenging lethal dose of 200 mg crude venom 270 days after the initial immunization or 90 days after the last booster injection. the resistance was demonstrable on the basis of a good correlation with antibody titers determined by the elisa method but not with the f ... | 2008 | 2590734 |
| [a case of argininosuccinate synthetase (ass) deficiency diagnosed by the measurement of ass with the liver biopsy specimen]. | 1989 | 2592835 | |
| the epidemiology of echinococcus granulosus in great britain. v. the status of subspecies of echinococcus granulosus in great britain. | twenty-five years ago williams and sweatman suggested that in great britain there are two subspecies of echinococcus granulosus--e. granulosus granulosus and e. granulosus equinus. echinococcus granulosus granulosus does not mature either in foxes or in horses: e. granulosus equinus will mature in either. the prepatent period of e. granulosus granulosus in the definitive host is about 42 days while that of e. granulosus equinus is about 70 days. each subspecies has a characteristic morphology. m ... | 1989 | 2596902 |
| a survey of leptospirological studies carried out on the cape verde islands. | the authors subjected 611 human sera, 1295 sera of domestic and 211 sera of wild living animals from two islands of the cape verde archipelago to serological tests for leptospirosis. among the human sera 7.2% reacted positively. antibodies to l. bratislava of the serogroup australis were most frequent (59.1% of all positive sera). antibodies to l. icterohaemorrhagiae were found in 1.3% of the sera tested, to l. sejroe in 1.1%, to l. canicola in 0.7%, to l. pyrogenes in 0.3% and to l. pomona, l. ... | 1989 | 2599387 |
| stimuli of thirst in donkeys (equus asinus). | a study of the stimuli of thirst was conducted on six feral donkeys. donkeys were found to be stimulated to drink by overnight water deprivation, by the diuretic furosemide, and by hypertonic saline infusion, all in the absence of heat stress or work. donkeys compensate accurately for the fluid deficit caused by overnight water deprivation. after 19 hr without water, they drank 8.8 +/- 2.4 (mean +/- se) liters within 60 min. their undeprived overnight intake was 8.4 +/- 1.5 liters. however, late ... | 1989 | 2602491 |
| reciprocal unconditional-conditional organization of the fundamental emotions and paraadaptive personality reactions. | paraadaptive personality reactions (ppr) are modes of behavior and experience on the borderline of normal psychology and psychopathology. in them the thinking is overdetermined or obsessive. overdetermined ppr are well illustrated in common proverbs. the people's wisdom has also knowledge of the obsessive (or "magic") paraadaptive rituals for prevention of possible misfortunes (such as touching wood, keeping away from a black cat, etc.). one part of the ppr is described in the psychoanalytical l ... | 1989 | 2616226 |
| babesia equi and trypanosoma vivax infections in donkeys. | six donkeys (equus asinus) were purchased locally. to screen them before and during trypanosoma vivax infection, thin and thick blood smears, temperature, haematocrit centrifuge technique (hct), packed cell volume (pcv), white blood cell counts, and indirect immunofluorescent antibody test (ifat) were done for babesia equi. for the ifat, an anti-horse conjugate was used. in spite of patent b. equi or t. vivax parasitaemia, the donkeys' temperatures remained below 38.5 degrees c; pcv was depresse ... | 1989 | 2626573 |
| [presence of nerve terminations in the episclera of the horse and ass]. | the episclera of horse and ass is provided, just like in the bovine, with both vegetative and sensitive somatic innervation. the former is constituted by isolated or grouped ganglionic cells located along the course of the nerve bundles. the sensitive nervous component consist, above all, of encapsulated receptors such as pacini, pacini-like and golgi-mazzoni corpuscles. most of these are pacini-like receptors which also show some structural features. in fact they are very small and supplied wit ... | 1989 | 2627337 |
| [optimal dosage of acetylsalicyclic acid (ass). ii: use in preventing thrombosis of the cerebrovascular circulation--prevention of strokes and preliminary stages]. | 1989 | 2651859 | |
| [sudden death during mass running events in switzerland 1978-1987: an epidemiologico-pathologic study]. | between 1984 and 1987 there were 7 cases of sudden cardiac death during organized mass runs in switzerland, and between 1978 and 1987 there were 3 cases during the nine largest mass running events (total 8 cases of sudden death during the race). based on numbers of participants in all events 1984-1987, or in the nine largest events 1978-1987, an incidence of 1 sudden death per 129,500 hrs. of running (95% confidence interval 1/62,500-1/263,000 hrs.), or 1 sudden death per 117,000 hrs. of running ... | 1989 | 2655076 |
| health effects of air pollutants: sulfuric acid, the old and the new. | data from exposure of experimental animals and human subjects to sulfuric acid presents a consistent picture of its toxicology. effects on airway resistance in asthmatic subjects were well predicted by data obtained on guinea pigs. sulfuric acid increases the irritant response to ozone in both rats and man. in donkeys, rabbits, and human subjects, sulfuric acid alters clearance of particles from the lung in a similar manner. these changes resemble those produced by cigarette smoke and could well ... | 1989 | 2667973 |
| phase-derivative imaging. ii: effects of beam diffraction and scatterer density. | the potential of using the phase derivative (pd) of the radio-frequency echograms for producing 2-dimensional grey scale images was further investigated. the pd images were produced by five different algorithms, which according to the results described in the companion paper yield pd images dominated by the amplitude (envelope, env), mixed pd-am images and pure pd images. these images are termed according to their algorithms: zcs, zero crossing counter with squelch; ass, analytic signal with squ ... | 1989 | 2675450 |
| [serologic studies of domestic animals for listeriosis, q-fever, and brucellosis in cairo]. | first serological investigations among domestic animals (donkey, goat, sheep, swine, dog) and rats (rattus norvegicus) carried out in the surroundings of persons from waste disposal sites in cairo indicate the occurrence of listeriosis, q fever and brucellosis. | 1989 | 2684762 |
| [endoscopic studies of gastroduodenal tolerance of 100 mg versus 500 mg acetylsalicylic acid daily: a randomized double-blind study with healthy probands]. | acetylsalicylic acid (ass) is increasingly used in the prevention of cardiovascular diseases. in recent years lower daily ass-doses (100-300 mg) have been given for this indication. however, only marginal knowledge is available about the upper gi-tolerability of ass in this dosage regiment. in a randomized double-blind study we have evaluated the gastroduodenal tolerability of 100 mg ass and 500 mg ass daily in 20 healthy volunteers using upper gi-endoscopy. both ass-dosages have been taken over ... | 1989 | 2692315 |