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[effect of the adrenocorticotropic hormone on peripheral blood levels of hydrocortisone, testosterone and their precursors in baboons].the time-course of changes in hydrocortisone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone and testosterone levels in the peripheral blood of male sacred baboons was studied after exogenous acth injection by radioimmunoassay. it was shown that the hydrocortisone secretion character following acth injection correlates with the change of other adrenal steroids studied: 17-hydroxypregnenolone, 17-hydroxyprogesterone and dehydroepiandrosterone. maximum concentration growth ...20166270645
[encephalomyocarditis in hamadryas baboons].in 1978--1979, four cases of encephalomyocarditis were recorded in baboons in a simian preserve of the ussr ams research institute of experimental pathology and therapy located in the zapadnyaya gumista river valley. the diagnosis was made on the basis of virological and pathomorphological examinations. the isolate recovered from the dead monkeys was identical with the prototype strain of encephalomyocarditis virus (emc) and the emc-70 strain previously isolated by us from m. rhesus monkeys. the ...19826291247
enzyme-linked immunosorbent assay for detection of antibodies to epstein-barr virus antigens.enzyme-linked immunosorbent assay (elisa) was standardized for measurement of antibody activity of reference human and baboon (papio hamadryas) sera to soluble epstein-barr virus (ebv) antigens. a comparison with the immunofluorescent (if) method showed that elisa detects antibody specifically and sensitivity. in elisa, herpesvirus papio (hvp) nuclear antigen (hupna) positive baboon serum reacted with ebv nuclear antigen (ebna), as a further indication of the antigenic similarity between hvp and ...19836318497
[etiological aspects of leukemias in primates including man].attempts have been made to induce viral leukemia in monkeys (papio hamadryas and macaca arctoides) by inoculating them with blood from humans with different types of leukemias. in hamadryas baboons, the disease spread horizontally. by today 218 p. hamadryas and 5 m. arctoides monkeys had died of malignant lymphoma. the following viruses have been isolated from sick monkeys: lymphotropic baboon herpes virus (hvp), endogenous baboon c type viruses--xenotropic (biln), and ecotropic (evpg). c type o ...19836318850
[study of virus-associated lymphomas in primates using a model of malignant lymphoma of the baboon].an outbreak of malignant lymphoma was registered in a population of hamadryas baboons. animals inoculated with blood from patients with various forms of leukemia were planted into the stock 10 years ago. 218 out of 3219 animals have already died from lymphoma. the morphological pattern of horizontally-spreading lymphoma was similar to basic cell patterns of hodgkin's and non-hodgkin lymphoma in man. as far as the immunologic classification of tumor lymphoid cells is concerned, baboon lymphomas w ...19836320540
[effect of luliberin and chorionic gonadotropin on luteinizing hormone and testosterone levels in the blood of monkeys under acute stress].the effect of immobilization stress on luteinizing hormone (lh) and testosterone (t) secretion following injections of luliberin (lh-rh) and human chorionic gonadotropin (hcg) was investigated in male hamadryas baboons. it was established that in control animals a single injection of hcg (4500 iu) led to a more prolonged and more demonstrable increase of plasma testosterone concentration than injection of a pharmacological dose (100 micrograms) of lh-rh. preliminary stimulation of the testes wit ...19846369303
new inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon.a new inhibitor of human renin (h. 189) is described. it is a decapeptide analogue of human renin substrate with the amino acid, statine, substituted for leucine in the scissile bond. its inhibitory potency as shown by ic50 is 1.0 x 10(-8) m with human plasma renin and 1.5 x 10(-8) m with baboon plasma renin. it is less effective with dog and rat renin, but its inhibitory potency with human renin is similar to that of another inhibitor of ours (h. 142) having a reduced isostere in the scissile b ...19836398331
fibrinopeptides a and b of baboons (papio anubis, papio hamadryas, and theropithecus gelada): their amino acid sequences and evolutionary rates and a molecular phylogeny for the baboons.amino acid sequences of fibrinopeptides a and b from savanna baboons, papio anubis and papio hamadryas, and highland baboon, theropithecus gelada, were established. the sequences of the fibrinopeptides a from the three baboons were identical: (sequence: see text) the fibrinopeptides b were composed of 9 residues and demonstrated the sequence: (sequence see text) where x3 = arg in p. anubis, his in p. hamadryas, and gly in th. gelada. position-3 of the b peptides was the only replacement site obs ...19836423621
[incidence of chromosome aberrations in the bone marrow of monkeys and their progeny after exposure to aflatoxin b1].a mutagenic effect of aflatoxin b1 (afb1) was studied in somatic cells of primates. it is shown that afb1 elevates the chromosome aberration frequency in bone marrow cells of two monkey species: macaca mulatta and papio hamadryas. genome mutations were found in these experimental primates simultaneously with chromosome aberrations. the afb1-induced chromosome aberrations were revealed at least during two years of the study. the fact of the chromosome aberration frequency increase was established ...19846431671
frequency of chromosome aberrations in bone marrow of monkeys and their f1 after aflatoxin b1 injection.a mutagenic effect of aflatoxin b1 (afb1) in somatic cells of primates is investigated. it is shown that afb1 elevated the frequency of chromosome aberrations in the bone marrow of two species of monkeys: macaca mulatta and papio hamadryas. beside chromosome aberrations, genome mutations were found in these experimental primates. afb1-induced chromosome aberrations were constantly revealed during two years of study. increase in the frequency of chromosome aberrations could be demonstrated in mac ...19846440807
characterization of various molecular species of follicle-stimulating hormone in baboon pituitary preparations.the properties of baboon (papio hamadryas) follicle-stimulating hormone (bfsh) have been studied after isoelectrofocusing (ief) of individual pituitary extracts from five female and three male baboons and of a partially purified bfsh preparation (cm-1). the in vitro bioactivities of the female and male pituitary extracts and of cm-1 were 6.0 (range 4.1-9.6), 10.8 (6.9-18.2), and 34.1 (30.3-38.3) mg equivalent of ler 1909-2 reference standard per mg protein, respectively. the corresponding ratios ...19846440996
[circadian rhythms of the sex steroids of female papio hamadryas in long-term hypokinesia].radioimmunoassay was used to study the effect of restricted motor activity on circadian rhythms of blood plasma sexual steroids and cortisol in female papio hamadryas during different phases of the menstrual cycle. instact animals manifested clear-cut circadian rhythms of the testosterone and cortisol content during both the phases and those of estradiol and progesterone during the follicular phase of the cycle. two-week immobilization did not produce any changes in the general pattern of circad ...19846487794
conservation of blood plasma fluids in hamadryas baboons after thermal dehydration.after 2 days of water deprivation in a warm climate, papio hamadryas baboons lost 10% of their body mass, 12.5% of their total body water (3h2o) space, but only 4% of their plasma volume [evans blue (eb) space]. hematocrit and hemoglobin concentration as well as blood viscosity and blood pressure were not affected by thermal dehydration. plasma colloid osmotic pressure (cop) in the dehydrated animals was, however, 8 torr higher than in fully hydrated baboons. total mass and concentration of plas ...19846490462
[effect of human chorionic gonadotropin on the endocrine function of papio testes].radioimmunoassay was used to study secretion of papio hamadryas testis under stimulation with human chorionic gonadotropin (hcg). it was discovered that hcg had an acute stimulating effect on testicular secretion of testosterone, androstendione and 17-hydroxyprogesterone. it was demonstrated that repeated stimulation with hcg in the presence of the maximal secretory response of the testis (24 h after the first injection and in the presence of its partial reduction (after 72 h) did not provoke an ...19846504879
endometriosis with bacterial peritonitis in a baboon.an adult female papio hamadryas being used in reproductive studies was found moribund unexpectedly. palpation revealed acute abdominal pain and a pelvic mass. a tentative diagnosis of endometriosis and shock was made. necropsy and histological examination confirmed the diagnosis of endometriosis and identified an associated bacterial peritonitis.19846513512
[testicular endocrine function in hamadryas baboons (papio hamadryas) during chronic emotional stress].radioimmunoassay was applied to examine the time course of blood plasma testosterone content in 10 adult male hamadryas baboons under repeated immobilization stress (is). in the first series of experiments, the monkeys (5) were subjected to daily is for 2 h during 6 days. in the second series, 5 animals were exposed to 2-hour immobilization 3 days prior to the analogous stressful cycle. in response to intermittent is the first series males demonstrated profound and long-term suppression of blood ...19846538448
standard values of blood constituents in free-ranging hamadryas baboons in the forests of abkhazia. 19836613371
[cytoarchitectonics of the frontal area fields of the cerebral cortex in the hamadryas baboon and the rhesus macaque in ontogeny].structural organization of the fields 8, 9, 10, 11, 12, 47, 44 + 45 + 46 has been studied in papio hamadryas and in macaca rhesus during pre- and postnatal periods of development. volumes of the fields, size of the cells, thickness of the cortex and its layers have been defined. not only certain similarities, but some essential differences have been revealed in the development of the fields mentioned. the differences are manifested in complicating the frontal area of the papio hamadryas cerebral ...19836615248
[effect of naloxone in hypotension caused by acute blood loss in papio hamadryas baboons].naloxone or physiological solution were injected in different doses to 11 baboons (papio hamadryas) weighing 7-8 kg after bloodletting in a volume of 40% of the total amount of the blood. naloxone effectively raised (in all the doses) the arterial blood pressure which dropped after bloodletting. the action of naloxone injected in small doses was more pronounced and had unique time parameters. besides, the respiratory rate was also increased. injection of nalorphine in a dose of 1 mg/kg produced ...19836626736
increased antibody responses to herpes virus papio (hvp) antigens in pre-lymphomatous baboons (papio hamadryas) of the sukhumi high lymphoma stock.antibody responses to herpes virus papio (hvp) antigens were studied in 21 pre-lymphoma baboons (which subsequently died of malignant lymphoma), 21 paired controls, i.e. age-, sex- and population-matched healthy baboons, and 185 randomly selected healthy baboons of the same population. the sera were all collected at the same time and were tested blind in the fixed-cell indirect immunofluorescence test against hvp viral capsid antigen (vca)-positive, early antigen (ea)-positive cell targets befor ...19836642757
[plasma corticosteroid level in male hamadryas baboons in various seasons of the year].the levels of hydrocortisone, 11-deoxycortisole, 17-hydroxypregnenolone, 17-hydroxyprogesterone, 20-dihydroprogesterone, pregnenolone and progesterone were measured in blood plasma of adult male hamadryas baboons within a year using radioimmunoassay. seasonal fluctuations characterized by the highest content of corticosteroids in spring-summer period and a considerable decrease of their concentration in autumn months have been revealed.20166647431
inbreeding effects on dental morphometrics in papio hamadryas.the dentition of nonhuman primates (papio hamadryas) was utilized to investigate the hypothesis that inbreeding will affect mean tooth size and shape. more than five hundred dental casts were collected from baboons at the institute of experimental pathology and therapy in sukhumi, ussr. in addition, inbreeding coefficients for each monkey were obtained from pedigree records, some going back seven to nine generations. each tooth was measured and scored for the presence of discrete morphological s ...19836650676
[characteristics of the adrenal endocrine function of papio hamadryas in the metopyrone test].hormonal function of the adrenals of preadolescent and adult monkeys (papio hamadryas) was examined by the metopyrone test. after a single injection of metopyrone the content of cortisol, 11-deoxycortisol, progesterone, pregnenolone, 17-hydroxyprogesterone and 17-hydroxypregnenolone was measured in the blood of monkeys by radioimmunoassay. the reasons for age-associated differences in the hormonal response of the primate adrenals to metopyrone injection are discussed. the conclusion is drawn on ...19846718337
[effectiveness of revaccinating hamadryas baboons with niss live dried plague vaccine and fraction i of the plague microbe].the effectiveness of some vaccine preparations for the revaccination of hamadryas baboons after their primary immunization with live plague vaccine " niis " administered in the form of aerosol was studied. the study was carried out under the conditions of the aerosol challenge of the animals with y. pestis. the subcutaneous injection of plague vaccine " niis " was found to have advantages over its aerosol administration. revaccination with y. pestis fraction i, absorbed, was found to be 8 times ...19846741359
fine structure of the parathyroid glands in baboons, papio hamadryas in response to experimental hypercorticoidism.female baboons maintained under laboratory conditions were subjected to a series of 10 weekly injections (4 mg/kg body weight) of the synthetic glucocorticoid, triamcinolone hexacetonide. in response to the treatment, serum immunoreactive parathyroid hormone (pth) levels were raised, though blood calcium levels remained within normal physiological limits. light and electron-microscopic studies were made on the parathyroid glands at the end of the experimental period. the baboon parathyroid gland ...19806770575
antistreptococcal antibodies, rheumatoid factors and haptoglobin in apes and monkeys.sera of 157 baboons (papio hamadryas and p. anubis) 21 chimpanzees (pan troglodytes) five orang utans (pongo pygmaeus) three mountain gorillas (gorilla gorilla beringei) and three gibbons (hylobates lar lar) were examined for the content of antistreptolysin o, antidesoxyribonuclease b, for the presence of rheumatoid factors as well as for the level and type of haptoglobin. the mean antistreptolysin o titer (ast) in baboons was 106 asu +/- 18 in dextransulfate absorbed sera ("real" ast) and 182 a ...19806775442
immunohistochemical localization of fsh and lh in the pars distalis of vervet (cercopithecus aethiops) and baboon (papio hamadryas) pituitaries.antisera against olh, beta olh and beta hfsh were used to localize gonadotropic cells in the pars distalis of cercopithecus aethiops and papio hamadryas. three separate cell types were observed for fsh and lh: 85% of immunohistochemically identified gonadotropic cells reacted to all the various antisera; 10% reacted with the anti-beta olh antibody only; and 5% with the anti-beta hfsh antibody only. comparisons between adjacent serial sections treated with various antisera, other than anti-gonado ...19816786752
[biological characteristics of lymphoid cell lines producing lymphotropic primate herpesviruses].lymphoid cell lines of monkey and human origin were characterized by proliferative activity, electrophoretic mobility, and percentage of colony-forming cells. papio hamadryas cell lines were divided into two types similar to those of humans. one of them includes cell lines of tumor origin with high proliferative activity, decreased electrophoretic mobility, and a high percentage of colony-forming cells. the other type includes lymphoblastic lines of non-tumor origin with low proliferative activi ...19836845722
the bp graded blood group system of the baboon: its relationship with macaque red cell antigens.the first blood group system to be defined in baboons by means of isoimmune agglutinating reagents is composed of five graded types: b4, b3, b2, b1 and b, inherited, as postulated, by five allelic genes with decreasing dominance order. there are significant differences in distribution of the bp blood groups between hamadryas baboons on the one hand, and cynocephalus and anubis on the other, which may serve as auxiliary taxonomic criteria. antibodies of specificities related to the bp graded anti ...19836884908
genetic variants of properdin factor b (bf) in papio hamadryas baboons. 19816914999
[changes in the hormone balance of the baboon papio hamadryas during chronic stress]. 20157020294
[structural organization of caudate-frontal relationships in lower monkeys].cellular structure of the caudate nuclei has been studied in intact monkeys (macaca rhesus and papio hamadryas) after bilateral extirpation of the frontal area fields. methods of retrograde cellular degeneration and quantitative analysis with application of the computer "klassimat" have been used. only in one macaca operated on, the frontal premotor and motor fields have been removed, in other monkeys the frontal fields have been predominantly removed. only in one macaca operated on, a statistic ...19817034692
[projections of the thalamic dorsomedial nucleus onto the prefrontal area of the cortex in hamadryas baboons].in 6 monkeys (papio hamadryas) by means of the retrograde degeneration method projections of the thalamic dorsomedial nnucleus on field 9, 10 and 47 in the prefrontal cortical area have been studied. morphological investigation of the frontal cerebral sections stained after nissl has demonstrated that multiform part of the thalamic dorsomedial nucleus makes projections towards field 9. the frontal superior sector of the parvocellular part of the dorsomedial ucleus is projected on field 10, and t ...19827115099
[induction of chromosome aberrations and mitotic disorders in a bone marrow cell culture of papio hamadryas in exposure to cytochalasin b].a 24-48 hours' treatment with cytocholasin b (1 mg/ml) increases significantly the number of chromosomal aberrations and mitotic abnormalities in primary cultures of bone marrow of the baboon papio hamadrias. the addition of erythropoietin in concentration of 0.25 units per ml, either before or after the addition of cytochalasin, increases the number of chromosomal aberrations due to hormone stimulation of cell division. at this concentration, erythropoietin alone does not induce any chromosomal ...19827135481
peripheral plasma levels of 12 steroids during pregnancy in the baboon (papio hamadryas). 19807194812
steroid-induced ultrastructural changes in the proximal convoluted tubule cells of baboon kidneys with special reference to peroxisomes.an electron microscopic study was performed on kidneys of immature female baboons, papio hamadryas, that received a series of 10 consecutive weekly injections of the synthetic glucocorticoid, triamcinolone hexacetonide (4 mg/kg body wt). in the steroid-treated kidneys the most distinctive change found is a significant increase in the number and a marked change in the form of peroxisomes (microbodies) in proximal convoluted tubule cells. these cells also develop hypertrophic mitochondria and in s ...19807212287
[characteristics of the relationship between the circadian rhythm of the concentrations of corticosteroids and their precursors in the blood of baboon hamadryas and the initial functional state of the pituitary-adrenal cortex system].the occurrence of a single-phase circadian rhythm in the content of cortisole, 11-deoxycortisole, 17-hydroxypregnenolone, 17-hydroxyprogesterone, pregnenolone and progesterone in the blood plasma of hamadryas baboons was established by radioimmunoassay with peak levels early in the morning and minimum ones in the evening. the time course of changes in aldosterone levels in the intact animals significantly differs from that in the adapted ones. the maintenance of animals under other ecological co ...19817225562
[peculiarities of the adrenal cortex in response to repeated stress in papio hamadryas hamadryls during different phases of the sexual cycle]. 20137257668
[circadian rhythm of cortisol levels and its precursors in different phases of the menstrual cycle in baboons].radioimmunoassays were used to study in experiments on sacred baboons the circadian rhythms of dehydrocortisone, 11-deoxycortisol, progesterone, pregnenolone and 17-hydroxypregnenolone in the folliculin and luteal phases of the menstrual cycle. the circadian rhythms of dehydrocortisone and 11-deoxycortisol secretion were seen in both phases of the cycle. the maximum content of the plasma steroids were recorded in the morning while the minimum one in the evening and at night. the circadian rhythm ...20167291143
[changes in the morphological and cytogenetic indices of the hematopoietic system of papio hamadryas in chronic irradiation at low doses]. 20067313090
[macroscopic structure of the inferior tracheobronchial lymph nodes of papio hamadryas baboons].the investigation has been performed in 58 corpses of practically healthy papio hamadryas beginning from birth up to 20 years of age. age changeability is manifested as an increasing size and number of the nodes in the group, as the connective tissue framework development (thickening of the capsule and increasing number of trabecules) as well as increasing complexity in the structure of the cortical and medullary substance, by the time of puberty they reach their optimal correlation. seasonal ch ...19817316808
sexual dimorphism in two subspecies of ethiopian baboons (papio hamadryas) and their hybrids.sexual dimorphism in mammals has been related to such variables as absolute body size, ecology, and various aspects of social behavior. attempts to relate dimorphism to any of these variables have necessarily used small heterogeneous samples to represent the relevant species. we are concerned by the inevitable exclusion of any measure of variability in dimorphism and the consequent impossibility of assessing the significance of observed interspecific differences. in this paper we describe aspect ...19817325215
[hemorrhagic diathesis and hematopoiesis in papio hamadryas with hemoblastoses]. 19817336669
home range and daily march in a hamadryas baboon troop. 19817338334
isolation of lymphotropic baboon herpesvirus (hvp) from oral swabs of hamadryas baboons of the sukhumi monkey colony.ways of lymphotropic baboon herpesvirus (hvp) secretion and its excretion into the environment were investigated. oral swabs and feces from the sukhumi main stock hamadryas baboons characterized by a high risk for malignant lymphoma and the baboon stock living in isolation in the forest were used as materials for the investigations. macaque groups of the sukhumi stock were used as controls. it could be shown that the hvp was resistent in the oral cavity of the main stock baboons and was isolated ...19807409079
[construction and cellular composition of the deep cervical lymph nodes of hamadryad baboons].the deep cervical lymph nodes in the papio hamadryas at the age of 1.5--2.5 years have a peculiar even distribution of the cortical and medullary substances, and in histological sections a comparatively small area is occupied by follicles (predominantly by those without light centers), myelin cords and some portal sinuses. every structure studied has its own set of cellular elements, but lymphocytes are the predominant cellular form in every structural component. plasmic cell content in the cort ...19807436763
a reassessment of the karyotype of papio ursinus. homoeology between human chromosome 15 and 22 and a characteristic submetacentric baboon chromosome.the giemsa-banded karyotype of the chacma baboon, papio ursinus, was shown to be identical to that of papio hamadryas. comparison of g-banded p. ursinus (pur) chromosomes with those of man (hsa) showed close morphological homoeology between pur and hsa chromosomes 5, 8, 12, 19, and x, and partial homology for seven and 22 and was the only papio chromosome containing a nucleolar organizer region (nor). this baboon chromosome, therefore, shows genetic homoeology with human acrocentrics for a least ...19807449436
haemodynamic actions of a nitric oxide (edrf) synthesis inhibitor in conscious baboons (papio hamadryas).1. the haemodynamic effects of intravenous nitric oxide inhibitor, n-nitro-l-arginine (nola), were examined in four conscious non-restrained baboons (papio hamadryas). mean arterial pressure, (map), systemic vascular resistance (svr) and cardiac output (co) were measured at timed intervals up to 24 h after a bolus injection of nola. 2. n-nitro-l-arginine increased blood pressure in a dose-dependent manner up to 9.5 mg/kg. increases in blood pressure were accompanied by increases in svr and decre ...19947529664
a baboon (papio hamadryas) model of insulin-dependent diabetes.over a period of four years, streptozocin has been used to induce diabetes in 10 baboons, all of whom are insulin dependent. we describe our experience with their husbandry, induction of diabetes, insulin therapy, metabolic control and growth rate. streptozocin dosage of 60 mg/kg readily induces hyperglycemia with minimal hepatic or renal toxicity. using a once daily injection of mixed short and intermediate acting insulins at a dosage of 2-4 u/kg, it is possible to maintain a degree of metaboli ...19957563008
a non-human primate study (baboon; papio hamadryas) to determine if a long-acting progestogen, levonorgestrel butanoate, combined with a long-acting androgen, testosterone buciclate, can suppress spermatogenesis: i. dose-finding study.this study in adult male baboons was conducted to establish the dose of a long-acting progestogen, levonorgestrel butanoate, and that of a long-acting androgen, testosterone buciclate, which, when combined, would achieve optimal and prolonged suppression of spermatogenesis. two intramuscular injections of levonorgestrel butanoate at 3-month intervals and in the dose range 1-8 mg/kg reduced sperm production and plasma concentrations of testosterone, lh and fsh for periods of up to 6 months. the s ...19957665213
a non-human primate study (baboon; papio hamadryas) to determine if a long-acting progestogen, levonorgestrel butanoate, combined with a long-acting androgen, testosterone buciclate, can suppress spermatogenesis: ii. efficacy study.two combined injections of levonorgestrel butanoate (4 mg/kg) and testosterone buciclate (8 mg/kg) at 3-month intervals to adult male baboons initiated a decrease in sperm concentration from baseline values of 490x10(6)/ml to minimum values of 17x10(6/ml. this suppression was sustained until week 32, during which time between one and three azoospermic samples were collected from each of four out of five treated baboons in the period 10-24 weeks. circulating plasma levels of lh and testosterone d ...19957665214
establishment and characteristics of an interleukin-2-dependent stlv-1-producing lymphoid cell line, sph-7(t), obtained from papio hamadryas with malignant lymphoma. 19947842161
brainstem auditory evoked response development in preterm and term baboons (papio hamadryas).brainstem auditory evoked responses were recorded longitudinally from 11 neonatal baboons (papio hamadryas), 6 of which were preterm. recordings were made in unsedated animals from day 161 to day 362 after conception (term = 182 days). the pattern of development of both waveform morphology and of wave latency was consistent with that seen in the human neonate, with a rapid maturation of the response during the perinatal period, and then a slower development to adult values. brainstem conduction ...19947842507
[spontaneous coronavirus infection in monkeys].a high level of the spread of coronavirus (cv) infection among hamadryas baboons and macaques of different species (about 50%), both resident in the animal house and imported, has been established. the tropism of cv to the gastrointestinal and respiratory tracts has been demonstrated. the course of spontaneous cv infection is accompanied by enterocolitis and/or pneumonia with periodic exacerbations, or takes the inapparent form. cases of virus persistence have also been noted. infected macaques ...19947856336
observations on the ascending aortic fold in two chacma baboons (papio hamadryas ursinus).baboons (papio) were used to study the ascending aortic fold. the fold was present in two out of 20 hearts examined. its position and shape was comparable to that observed in human subjects. the principal difference was the absence of paraganglia. the functional role of the baboon fold is unclear.19947897641
[the cytogenetic characteristics of b-lymphoid lines from papio hamadryas baboons and macaca arctoides brown macaques].a cytogenetic analysis of 9 permanent suspension cell lines was performed. cell lines were obtained from papio hamadryas and macaca arctoides cells by different methods. five cell lines originated from non-malignant parental cells. lines spg-5 and spg-6 were analysed at early stages of cultivation, with normal karyotypes being identified. in cell lines pl-11, mal-1 and mal-4 pathological clones with structural and numerical chromosomal rearrangements appeared only following a long-term cultivati ...19947900211
[a new variant of the simian t-lymphotropic retrovirus type i (stlv-if) in the sukhumi colony of hamadryas baboons].polymerase chain reaction (pcr) was developed for the detection of simian t-lymphotropic virus type 1 (stlv-1) infection of p. hamadryas and direct sequencing using oligo-nucleotide primer pairs specific for the tax and env regions of the related human t-lymphotropic virus type 1 (htlv-1). excellent specificity was shown in the detection of stlv-1 provirus in infected baboons by pcr using htlv-1-derived primers. the nucleotide sequences of env 467bp and tax 159bp of the proviral genome (env posi ...19937905690
a primate t-lymphotropic virus, ptlv-l, different from human t-lymphotropic viruses types i and ii, in a wild-caught baboon (papio hamadryas).searching for clues to the evolution of the primate t-lymphotropic viruses (ptlvs), which include the human and the simian t-lymphotropic viruses (htlv and stlv), we have identified another ptlv, which differs sufficiently from the known ptlv-i and ptlv-ii types to be designated here ptlv-l. the virus was isolated from a wild-born baboon (papio hamadryas) from eritrea. in a cdna library a 1802-bp-long fragment was identified that extends from the env region, including the complete transmembrane ...19947908445
recombinant growth hormone and insulin-like growth factor i do not alter gonadotrophin stimulation of the baboon testis in vivo.in vitro studies indicate a physiological role for insulin-like growth factor i (igf-i) in paracrine regulation of testicular function and recent clinical studies suggest a potential role for growth hormone (gh) and/or igf-i in the treatment of hypogonadotrophic states in males. this study aimed to examine the effects of pretreatment with recombinant human gh (rhgh) or rhigf-i on the response to gonadotrophins of the non-human primate testis in vivo. using a balanced latin square design with rep ...19947921230
[the immunological efficacy of francisella tularensis outer membranes for hamadryas baboons].the protective properties of the preparation of f. tularensis outer membranes (om), obtained from f. tularensis vaccine strain 15, were studied in experiments on hamadryas baboons challenged subcutaneously with f. tularensis virulent strain schu (nonarctic subspecies). the subcutaneous immunization with the om preparation prevented the development of clinically pronounced infection in more than 70% of the monkeys challenged with f. tularensis strain schu in a dose of 787 live microbial cells 30 ...19947941871
temporal organisation of action in baboons: comparisons with the temporal segmentation in chimpanzee and human behaviour.the durations of sequences of functionally related movements, or action units, were analysed in the baboons papio hamadryas and papio anubis. action units are completed within a narrow time span or temporal segment as found previously in pongids and humans. although the temporal segmentation is generally similar in the three species, baboons show several differences from both chimpanzees and humans. firstly, their temporal segments are shorter and less variable and the different sorts of action ...19947953607
infection of a yellow baboon with simian immunodeficiency virus from african green monkeys: evidence for cross-species transmission in the wild.many african primates are known to be naturally infected with simian immunodeficiency viruses (sivs), but only a fraction of these viruses has been molecularly characterized. one primate species for which only serological evidence of siv infection has been reported is the yellow baboon (papio hamadryas cynocephalus). two wild-living baboons with strong sivagm seroreactivity were previously identified in a tanzanian national park where baboons and african green monkeys shared the same habitat (t. ...19947966642
helminthic infestation complicated by intussusception in baboons (papio hamadryas).two juvenile baboons presented with diarrhoea, which did not resolve completely following antibiotic therapy. ileal intussusception was identified at autopsy in both cases. trichuris was the only gastrointestinal pathogen for which evidence could be found. this helminth is well-recognized as a cause of intussusception in human infants, but the complication has not been reported previously in non-human primates. it is likely to be fatal if undiagnosed.19947967467
[the evaluation in hamadryas baboons of the possibility for the specific prevention of ebola fever].the protective role of virus-neutralizing antibody was demonstrated in ebola virus-infected animals (papio hamadryas) used in experiments on the development of passive humoral immunity by using specific immunoglobulin. two immunizations of the monkeys with purified concentrated ebola virus antigen with complete freund adjuvant was shown to confirm intensive immunity to subsequent challenge protecting 80% of the immunized animals. it is concluded that effective preparations may be developed for s ...19948017061
baboon and cotton-top tamarin b2m cdna sequences and the evolution of primate beta 2-microglobulin.nonhuman primates represent phylogenetic intermediates for studying the divergence of human and murine beta 2ms. we report the nucleotide sequences of b2m cdna clones from a baboon cell line, 26cb-1 (papio hamadryas; primates: cercopithecoidea), and a cotton-top tamarin cell line, 1605l (saguinus oedipus; primates: ceboidea). the baboon and tamarin b2m sequences indicate a very slow rate of b2m evolution in primates relative to that in murid rodents. phenotypic evolution of beta 2m has also been ...19948026986
[the properties of simian coronavirus].properties of 20 coronavirus (cv) isolates obtained from spontaneously infected papio hamadryas and rhesus monkeys were investigated. two of them were selected as simian cv prototype strains-cvrm 281 (rhesus monkey) and cvp 250 (papio hamadryas), and can be offered as candidates to the coronaviridae family. they are closely related to each other, but differ in some biological properties and polypeptides. these strains belong to the 2nd antigen group of mammalian cv with the prototype strain hcv ...19938073751
fetotoxicity of angiotensin-converting enzyme inhibition in primate pregnancy: a prospective, placebo-controlled study in baboons (papio hamadryas).serious concerns have been raised about angiotensin-converting enzyme inhibition in pregnancy. the central question remains: does toxicity of angiotensin-converting enzyme inhibition pertain to pregnant humans?19948092208
nuclear dna polymorphisms in a wild population of yellow baboons (papio hamadryas cynocephalus) from mikumi national park, tanzania.yellow baboons (papio hamadryas cynocephalus) from mikumi national park, tanzania were studied for polymorphisms in nuclear dna. the study population consists of four social groups that inhabit overlapping home ranges and exchange males. as a result, these groups are considered to be members of a single interbreeding population. human dna clones were used as probes to screen five loci (at3, ren, hexb, vim, and apob) for restriction fragment length polymorphisms (rflp). a total of 14 polymorphism ...19938097371
cross-sectional growth standards for captive baboons: i. organ weight by chronological age.we present the first cross-sectional organ weight reference standards for captive baboons (papio hamadryas). organ weight data were obtained from necropsy reports for 634 healthy, pedigreed, captive female and male baboons. from summary statistics we calculated and fit cross-sectional, sex-specific percentile curves for: adrenals, brain, eyes, heart, kidneys, liver plus gall bladder, lungs, pancreas, pituitary gland, spleen, and thyroid gland in two year age class intervals and summary statistic ...20078169943
cross-sectional growth standards for captive baboons: ii. organ weight by body weight.we present the first cross-sectional organ weight by body weight reference standards for captive baboons (papio hamadryas). organ weight data were obtained from necropsy reports for 634 healthy, pedigreed, captive female and male baboons. from summary statistics we calculated and fit cross-sectional sex-specific percentile curves for: adrenals, brain, eyes, heart, kidneys, liver plus gall bladder, lungs, pancreas, pituitary gland, spleen, and thyroid gland in three kilogram body weight intervals ...20078169944
[the effect of psychotropic preparations on the behavioral and hormonal manifestations of emotional stress in monkeys].ethological and radioimmunological techniques were used to examine the effects of psychotropic agents on the behaviour of the male papio hamadryas and the hormonal activity of the steroid-producing glands at physiological rest and during emotional stress. prior (15 minutes before immobilization) intramuscular administration of haloperidol, 0.1 mg/kg, amitriptyline, 2.0 mg/kg or diazepam, 0.76 mg/kg, was demonstrated to produce no stress protective effect, but to result in predominant effects of ...19938220002
a primate model of monotypism in atherosclerotic lesions.we have characterized the expression of allelic variants of x-linked glucose 6-phosphate dehydrogenase (g6pd) in aorta from homozygous, hemizygous, and heterozygous baboons (papio hamadryas). fibrous plaques from heterozygous baboons fed a high cholesterol, saturated fat diet contained distributions of g6pd allelic variants that differed from those of normal arterial wall and fatty streaks. the skewed allelic expression patterns in fibrous plaques of heterozygotes reflect decreased cellular hete ...19938224112
integrating behavior and cardiovascular responses: posture and locomotion. i. static analysis.heart rate, arterial blood pressure, and renal and mesenteric or femoral blood flow were telemetered from 11 papio hamadryas in an untethered free-ranging situation. the animals' behavior was recorded on videotape, and the cardiovascular (cv) data were recorded on the audio channels of the tape. the behavior was coded, and the codes were linked to the cv data via a time-code generator and computer control. the cv data were digitized into 1-s intervals, and the static relations between cv measure ...19938285290
[a trial to produce an inactivated lassa fever vaccine].a single and double immunization of papio hamadryas monkeys with an inactivated concentrated purified adsorbed preparation of lassa virus in doses of 0.5-1.0 and 1.1-2.1 mg by protein, respectively, protected the animals against the development of the disease and occurrence of viremia after an intramuscular challenge with 0.4 pfu dose. upon aerogenic infection of monkeys protection of 50% of the animals was achieved by a single immunization with the inactivated preparation in a dose 1.1 mg by pr ...19938303891
effect of protein diets on the renal function of baboons (papio hamadryas) with remnant kidneys: a 5-year follow-up.to assess the progression of renal disease and the effects of protein intake in a species phylogenically close to humans, 14 adolescent baboons (papio hamadryas) were subjected to infarction of one third of the left kidney and, 2 months later, to right nephrectomy. they were then randomized to a synthetic protein diet containing either 8% or 25% casein. hemodynamic and metabolic measurements were obtained in awake animals every 4 months. modest proteinuria developed immediately after left kidney ...19948311075
the sukhumi primate monkey model for viral lymphomogenesis: high incidence of lymphomas with presence of stlv-i and ebv-like virus.t-cell leukemia virus-like proviral sequences (stlv-i) as well as ebv-like sequences were detected in pbls and tissues of non-human primates (papio hamadryas baboons, green monkeys and macaca arctoides; sukhumi primate center/georgia) by pcr. surprisingly, two different types of stlv-i within papio hamadryas baboons were found. one of its represents the baboon prototype stlv-i-su described earlier, present in lymphomatous baboons from the "high-lymphoma stock", which shows about 83% homology to ...19938395624
corticotropin-releasing hormone in baboon pregnancy.during human pregnancy, plasma crh immunoreactivity (crh-ir) rises progressively, peaking during labor and falling after delivery. among animal species, only higher primates have elevated crh-ir during pregnancy. this study examines whether changes in plasma crh-ir in the baboon (papio hamadryas) are similar to those in the human. crh-ir was determined by ria in 16 baboons at different stages of gestation (44 samples) and in 3 males. assays were performed on vycor extracts of plasma and crh-ir d ...19938473382
linkage mapping in papio baboons: conservation of a syntenic group of six markers on human chromosome 1.we have established multipoint genetic linkage among six loci in baboons (papio hamadryas). published pcr primers designed to amplify five human microsatellite loci were used to amplify homologous loci in 229 pedigreed baboons. southern blotting was used to type two rflps in a functional gene (anti-thrombin iii) in a subset of those animals. all six loci are known to map to human chromosome 1q, a region of the genome predicted by karyotype studies to be conserved in baboons. pairwise recombinati ...19958530033
zoonotic intestinal parasites of hamadryas baboons papio hamadryas in the western and northern regions of saudi arabia.six hundred and thirty-three faecal samples were randomly collected and examined for ova and cysts of intestinal parasites from five groups of hamadryas baboons of different population densities, with different human contact and in different ecological conditions (al-baha, turabah and al-taif in south-western and al-rihat and al-akhal in north-western saudi arabia). nine parasites were recorded (giardia lamblia, entamoeba histolytica, escherichia coli, balantidium coli, enterobius sp., trichuris ...19958544227
androgens regulate circulating levels of insulin-like growth factor (igf)-i and igf binding protein-3 during puberty in male baboons.to examine the role of androgens in initiating the pubertal rise in circulating insulin-like factor-i (igf-i) levels, a longitudinal study of puberty in 13 male hamadryas baboons was conducted over 3 yr. the five control baboons commenced puberty (initial testicular enlargement) at a mean +/- se age of 4.2 +/- 0.4 yr. another eight baboons were castrated prepubertally; of those four received testosterone pellets (dose equivalent: 12.5-50 mg every 6 weeks) implanted se from the time of puberty. b ...19968550796
failure of experimental infection of baboons (papio hamadryas) with the eggs of asian taenia.the infectivity of the eggs of asian taenia sp. for humans is not known. using baboons (papio hamadryas) as a model to extrapolate the findings, three animals were exposed per os with 1000, 10,000 and 50,000 infective eggs of the asian taenia sp. the serological, biochemical, haematological and parasitological (based on necropsy) results show that baboons are refractory to the infection. it is concluded that the asian taeniid eggs may fail to develop in man.19958583131
[standardization of conditions for the evaluation of effectiveness of antibacterial drugs in pneumonic plague in sacred baboons].the signs of pneumonic plague in sacred baboons infected by aerosol are: fever, hurried breathing, depression and constantly increasing bacteremia. some infected animals isolate the plague microbes while coughing and thus could be a source of the infection. by the clinical and pathomorphological signs, pneumonic plague in sacred baboons is similar to that in humans which makes it possible to use the animals in the development of schemes for special prophylaxis and treatment of the disease. in ef ...19958593090
the presence of a divergent t-lymphotropic virus in a wild-caught pygmy chimpanzee (pan paniscus) supports an african origin for the human t-lymphotropic/simian t-lymphotropic group of viruses.we isolated a divergent simian t-lymphotropic virus (stlv) (strain pp1664) from a wild-caught african bonobo (pygmy chimpanzee, pan paniscus). molecular and phylogenetic characterization of this virus show that it reliably separates from the two well-established primate t-lymphotropic virus types, htlv-i/stlv-i (ptlv-i) and ptlv-ii, and from a third type isolated from an african-born papio hamadryas and designated by us as ptlv-l. four of eight bonobos kept at the antwerp zoo, belgium, showed an ...19968609475
influence of neuropeptides on the processes of higher nervous activity in primates. the action of cyclic analogs of enkephalins on the behavior of the lower monkeys.the effect of two cyclic enkephalin analogs (ivs-43 and ivs-46) on the group and individual behavior of rhesus macaques and hamadryas baboons has been studied. a pronounced influence of ivs-46 on competitive and operant goal-directed behavior of the monkeys was identified.19958614479
the genomic structure of a new simian t-lymphotropic virus, stlv-ph969, differs from that of human t-lymphotropic virus types i and ii.a new simian t-lymphotropic virus, stlv-ph969, was recently isolated from a wild-born hamadryas baboon. previous analysis had revealed that it differs sufficiently from the other htlv/stlvs to be considered a new type, provisionally designated primate t-lymphotropic virus-l. here we analyse a 3850 bp cdna fragment spanning the 3' part of the stlv-ph969 genome. the fragment encodes three major proteins: env, tax and rex. sequence comparison and phylogenetic analysis indicate that in general stlv- ...19968627239
the three human t-lymphotropic virus type i subtypes arose from three geographically distinct simian reservoirs.to investigate the origin of human t-lymphotropic virus i (htlv-i), strains of diverse geographical origin were analysed. we sequenced the ltr and env genes of htlv-i strains from brazil, central african republic, taiwan and zaire, and the simian t-lymphotropic virus type i (stlv-i) strain phsu1 from a baboon from the sukhumi primate centre. we performed phylogenetic analyses using neighbour-joining, parsimony and maximum likelihood methods. three separate htlv-i clusters were identified intersp ...19968627240
interspecies transmission of macaque simian t-cell leukemia/lymphoma virus type 1 in baboons resulted in an outbreak of malignant lymphoma.an outbreak of malignant lymphoma has been observed in one of the baboon (papio hamadryas) stocks of sukhumi primate center. more than 300 cases in this "high-lymphoma stock" have been registered since 1967. human t-cell lymphotropic virus type 1 (htlv-1)-related virus was implicated as the etiologic agent of sukhumi baboon lymphoma. the origin of this virus remained unclear. two possibilities were originally considered: the origin could be baboon simian t-cell leukemia/lymphoma virus type 1 (st ...19968627684
low blood protein heterozygosity in zoo-bred hamadryas baboons.an electrophoretic study of erythrocyte allozymes and serum proteins representing 32 genetic loci in 32 hamadryas baboons (papio h.hamadryas) from cologne and frankfurt zoos revealed biallelic polymorphism in phosphoglucomutase (pgm), mannose phosphate isomerase (mpi) and transferrin (tf). polymorphism amounted to p = 0.097 over 31 loci and observed heterozygosity to h(o) = 0.011, indicating significant reduction from the respective gene diversity parameters encountered in free-living hamadryas ...19968653592
[development and study of the properties of immunoglobulin against ebola fever].immunoglobulin to ebola fever has been for the first time prepared from hyperimmune equine blood sera by alcohol fractionation after cohn. preclinical study of the physicochemical and immunobiological properties of immunoglobulin showed that it protects up to 100% papio hamadryas infected intramuscularly at doses of 110 to 29 ld50 ebola virus. scheme for the use of ebola immunoglobulin has been experimentally validated.19958686265
effects of age, sex, and heredity on measures of bone mass in baboons (papio hamadryas).bone mass and bone density were estimated in 219 pedigreed baboons (papio hamadryas) by radiographic morphometry of the left second metacarpal. compact bone width (total bone width--medullary canal diameter) and bone ratio (compact bone width/total bone width) decreased with increasing age squared in both sexes. the heritability of medullary canal diameter was 0.64 +/- 0.11, of compact bone width was 0.40 +/- 0.15 and of bone ratio was 0.67 +/- 0.13. the results indicate baboons are a useful mod ...19958750499
comparative antigenicity of recombinant wild-type staphylokinase (sakstar) and a selected mutant (sakstar.m38) in a baboon thrombolysis model.staphylokinase, a bacterial plasminogen activator, is a potent, highly fibrin-specific but antigenic thrombolytic agent in humans. in an effort to attenuate the antigenicity of wild-type staphylokinase (sakstar variant), 2 of its 3 immunodominant epitopes were altered by substituting clusters of 2 or 3 charged amino acids with alanine, yielding the mutant sakstar.m38 (k35a, e38a, k74a, e75a, r77a), which was less antigenic in inbred new zealand white rabbits. in the present study, groups of 6 ba ...19968761847
hamadryas baboons papio hamadryas as maintenance hosts of schistosoma mansoni in saudi arabia.free ranging hamadryas baboons (papio hamadryas) in four localities in the west and north of saudi arabia were examined for natural infection with schistosoma mansoni. faecal examination revealed infection with s. mansoni on four occasions within one year (at a prevalence rate of 2.5-4.0%) in only one locality, the al-baha area. the eggs were viable, as shown by miracidial hatching tests, and were recorded at a density of 140-280 eggs/g of faeces (7000-14,000 eggs/day). post-mortem examination o ...19968765452
questions on the evolution of primate t-lymphotropic viruses raised by molecular and epidemiological studies of divergent strains.in human and simian t-lymphotropic viruses (htlv and stlv), collectively referred to as primate t-lymphotropic viruses (ptlv), four distinct clades can be distinguished: ptlv-i, ptlv-ii, and the newly discovered divergent stlvs isolated from hamadryas baboons and from bonobos (pygmy chimpanzees). the hamadryas stlv is clearly distinct from types i and ii, in terms both of sequence divergence and of genomic structure, and would qualify as a separate type, provisionally called ptlv-l. the bonobo s ...19968797730
a comparison of tspy genes from y-chromosomal dna of the great apes and humans: sequence, evolution, and phylogeny.the genes for testis-specific protein y (tspy) were sequenced from chimpanzee (pan troglodytes), gorilla (gorilla gorilla), orangutan (pongo pygmaeus), and baboon (papio hamadryas). the sequences were compared with each other and with the published human sequence. substitutions were detected at 144 of the 755 nucleotide positions compared. in overviewing five sequences, one deletion in human, four successive nucleotide insertions in orangutan, and seven deletions/insertions in baboon sequence we ...19968798990
phylogenetic characterization of simian t lymphotropic virus type i (stlv-i) from the ethiopian sacred baboon (papio hamadryas). 19968835205
the development of the baboon prostate: ultrasound methodology, modelling, and natural history.in order to evaluate the potential of ultrasound for serial, nontraumatic estimation of prostate size in the hamadryas baboon (papio hamadryas), we adapted the technique of planimetric ultrasound to study a captive-bred colony of 30 male baboons (median age 8.4 years, range 3.3-17 years) including 4 long-term castrates. most (19) were studied on another two occasions (at 33-and 43-day intervals) to estimate reproducibility of the prostate size (dimensions, volume) measurement. prostatic dimensio ...20168889696
cyclical changes in the renin-angiotensin-aldosterone system during the menstrual cycle of the baboon (papio hamadryas).this study characterizes the renin-angiotensin-aldosterone system during the normal menstrual cycle in the baboon. ten animals received a daily dose of an ace inhibitor or placebo in a randomized blind cross-over design. data were obtained during the mid-follicular and early luteal phases of normal non-pregnant menstrual cycles. all examinations and blood collections were performed with ketamine sedation: 7-kg by im injection. blood pressure was recorded by sphygmomanometer. serum ace activity w ...19968906605
reproductive and neonatal outcomes in captive bred baboons (papio hamadryas).baboons are widely used in biomedical research. although it is widely held that papio hamadryas breed well in captivity, each established colony has a different reproductive success often hypothesised to be due to husbandry practices. the national baboon colony in australia is a unique colony that houses papio hamadryas to mimic that structure seen in the wild. in this article; we have analysed their reproductive parameters and neonatal outcomes. the success of the colony husbandry practices was ...19968906608
a unique design for ease of access and movement of captive papio hamadryas.baboons are widely used in biomedical research but their size and behaviour present potential problems with accessibility. a unique system has been developed that ensures ease of access to all animals in a colony of papio hamadryas. two distinct caging complexes were linked by a network of overhead races, that are connected to a physical restraint area where individual animals could be separated, restrained and weighed without being handled. access to and separation of individual family groups w ...19968938619
molecular features of the tspy gene of gibbons and old world monkeys.restriction pattern, chromosome localization and the sequence of the testis-specific gene, tspy, were investigated in the white-handed gibbon, agile gibbon, siamang, hamadryas baboon and japanese monkey. southern blot analysis showed the tspy gene to be male specific in the primates used and disclosed variability of restriction pattern in gibbons. fluorescence in situ hybridization demonstrated that the probe pptspy2372, biotinylated using polymerase chain reaction, is located as a slight signal ...19968939361
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