Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| definition of two ld antigens in rhesus monkeys. | two rhesus (macaca mulatta) monkey lymphocyte-defined (ld) antigens have been identified using two typing cells as stiumlators in a one-way mixed leukocyte culture (mlc) assay. an analysis of the genetic behavior of these ld antigens in six rhesus monkey families revealed that both antigens were linked with rhla. one probable recombinant indicated that the ld locus lies outside the two known rhla-sd loci and the locus which controls the serum protein, properdin b(bf). these two antigens, ld1 and ... | 1979 | 87026 |
| two plasmodium knowlesi-specific antigens on the surface of schizont-infected rhesus monkey erythrocytes induce antibody production in immune hosts. | purified schizonts (6--10 nuclei) and membranes of schizont-infected erythrocytes from the malaysian and philippine strain of plasmodium knowlesi are analyzed immunochemically using immunoglobulin of rhesus monkey hyperimmune sera against schizonts and of sera from naturally immune monkeys. the anti-schizont ig identifies less than 20 immune components in triton x-100-solubilized schizonts and membranes of infected cells. of these antigens, 9 (component 1, 3, 4, 5, 6, 10, 11, 18, and 20) are com ... | 1979 | 87490 |
| suppression and reversal of allergic encephalomyelitis in rhesus monkeys with basic protein and peptides. | we have extended earlier studies on the suppression of clinically evident experimental allergic encephalomyelitis (eae) in monkeys, repeated injections of human basis protein. the results confirm that after suppressive treatment, recovered animals remain clinically normal and do not show spontaneous recurrence of symptoms. however, recovered animals are susceptible to eae upon renewed challenge, and they develop the disease more rapidly and more severely than after the initial challenge; resuppr ... | 1979 | 88679 |
| the major histocompatibility complex of rhesus monkeys. xii: cellular typing for d locus antigens in families. | typing cells (tc) were used for the identification of d locus antigens in rhesus monkey families. the antigens defined by this cellular method always segregated with the other rhla-controlled markers except in one offspring with a proven recombination within the rhla region; in that case, the d antigen was inherited in coupling with an antigen of the ia1 locus (the analog of the human dr locus). with two exceptions, each tc or group of tc's was associated with one of the serologically defined ia ... | 1979 | 88774 |
| the pathophysiology of asthma. | because postmortem studies of humans provide little information on the initial pathophysiologic events in asthma, animal models have been developed. recently the ascaris-allergic rhesus monkey has provided an opportunity to examine the onset of pathophysiologic changes following challenge and to correlate them with airway structure. these studies have suggested that the initial interaction between antigen and mast cells may occur in the bronchial lumen or in the epithelium superficial to the tig ... | 1979 | 89006 |
| vitreous body oxygen tension following experimental branch retinal vein obstruction. | we obstructed either temporal or nasal superior and inferior retinal veins on one eye of rhesus monkeys with xenon photocoagulation. this resulted in large areas of nonperfused retina adjacent to normal retina in the same eye. intraretinal neovascularization (new vessels in the retina) developed following the absorption of retinal hemorrhage and edema. we used microelectrodes to measure and compare vitreous body oxygen tensions over the nonperfused and over the normal retinal areas. there was no ... | 1979 | 90026 |
| protection of rhesus monkeys from lassa virus by immunisation with closely related arenavirus. | 1979 | 90819 | |
| hyperacute experimental allergic encephalomyelitis in rhesus monkeys as a model of acute necrotizing hemorrhagic encephalomyelitis. | a comparative study of clinical and morphological findings in three fatal cases of acute necrotizing hemorrhagic encephalomyelitis (anhe) and hyperacute experimental allergic encephalomyelitis (heae) in rhesus monkeys is reported. in all cases anhe was characterized clinically by definite prodromal respiratory infection. the course was rapidly progressive with fatal termination. the salient histopathological changes were necrosis of blood vessels with plasma exudation and fibrin impregnation, he ... | 1979 | 92540 |
| production of antibodies to human immunoglobulins in a gibbon. | immunization of a chimpanzee, a gibbon, a baboon and a rhesus monkey with human globulins gave different results. while chimpanzees did not produce any anti-human antibodies, baboon and rhesus monkey responded by producing anti-human igg antibodies that did not show subclass or allotype specificity. in the gibbon antiserum, on the other hand, six different antibodies were demonstrated with a specificity against one or more of the four human igg subclasses, including one allotype. comparative inv ... | 1979 | 93346 |
| has myelin basic protein received a fair trial in the treatment of multiple sclerosis? | autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (ms). enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (eae) to test this hypothesis. reports of therapeutic failure of the encephalitogen myelin basic protein (bp) in the treatment of ms have their counterparts in similar therapeutic failures in eae. only highly inbred strain 13 guinea p ... | 1979 | 93873 |
| myelin basic protein treatment of experimental allergic encephalomyelitis in monkeys. | treatment of experimental allergic encephalomyelitis (eae) in two strains of monkeys with large amounts of myelin basic basic protein (bp) fails unless an adjunct is also used. in both strains the adjunct by itself is more effective than bp by itself, but in the one strain which could be investigated sufficiently, the combination can be made almost totally effective in reversing eae. the adjunct varies with the strain of monkey, an antibiotic in macaca mulatta and a steroid in macaca fasciculari ... | 1979 | 93874 |
| histochemical studies of mucosubstances and keratins of thymic corpuscles. | keratin and prekeratin have been visualized histochemically by testing the reactivity of disulfide groups in the thymic corpuscles of the sheep. rhesus monkey, rabbit and dog, and the reactivity of sulfhydryl groups in the sheep, rhesus monkey, rabbit and rat. ten to 50% of the thymic corpuscles showed keratinization by this method. acidic mucosubstances were visualized histochemically in the rhesus monkey, sheep and rat but not in the rabbit. staining for vic-glycol groups was prominent in all ... | 1979 | 94996 |
| oral progestational activity of spironolactone. | spironolactone has progestational activity in the rabbit and rhesus monkey. it produced glandular development in the endometrium of the estrogen-primed immature female rabbit over the dosage range of 50 to 200 mg/kg and, at 400 mg/monkey, it delayed estrogen-withdrawal bleeding in ovariectomized monkeys and it inhibited menstruation in regularly cycling monkeys. these data are consistent with the menstrual irregularity and amenorrhea seen in women during treatment with spironolactone. | 1978 | 95623 |
| a new substance resembling luteinizing hormone in the blood of rhesus monkeys. | sera from a number of rhesus monkeys showed low or undetectable levels of lh according to radioimmunoassays which employ radioiodinated rhesus lh and antisera against rhesus lh or hcg. these same sera, when assayed by a system utilizing radioiodinated ovine lh and a unique anti-ovine lh serum which cross-reacts with lh from a variety of species, appeared to contain large and variable quantities of lh. the chromatographic behavior on sephadex g-100 of the lh-like material in these sera was indist ... | 1977 | 95703 |
| further evidence of impaired tactile learning after removals of the second somatic sensory projection cortex (sii) in the monkey. | four rhesus monkeys with bilateral removals of sii and five unoperated monkeys were trained on tests of tactile equivalence, weight discrimination and generalization, tactile discrimination learning (including concurrent learning and serial reversal) and inter-manual transfer of tactile learning. lesioned animals were impaired on almost all tactile learning tasks and on inter-manual transfer but not on the test of tactile equivalence nor on the propioceptive tasks. the results are considered in ... | 1978 | 95960 |
| mechanisms of neural integration in the parietal lobe for visual attention. | the impulse discharges of neurons in the inferior parietal association cortex (area 7) were studied in the alert, behaving rhesus monkey, trained to fixate and follow visual targets. four classes of cells related to visual or visuomotor function were found. cells of one of these are sensitive to visual stimuli and have large, contralateral receptive fields with maximal sensitivity in the far temporal quadrants. cells of the other three classes are related to visuomotor functions: visual fixation ... | 1978 | 95976 |
| fertility in the rhesus monkey following long-term inhibition of ovarian function with danazol. | danazol was previously reported to be an oral contraceptive in the rhesus monkey at doses of 200 and 400 mg/monkey/day for 90 days. the drug is now shown to be an effective long-term inhibitor of ovarian function in the monkey. in the final 3 months of a 27-month period of treatment at a dose of 400 mg/monkey/day, the drug continued to be an effective oral contraceptive. during the 27-month treatment period, three of seven monkeys were amenorrheic and the remaining had only 16 of the 109 expecte ... | 1978 | 95978 |
| metabolism in vitro of 3h-testosterone in testis, epididymis & sex accessories of the rhesus monkey macaca mulatta: effects of cyproterone acetate on androgen metabolism. | 1977 | 96015 | |
| chrinic toxicity studies of centchroman in rats & rhesus monkeys. | 1977 | 96022 | |
| the effect of blood on ocular fundus reflectance and determination of some optical properties of retinal blood vessels. | light reflected from 50 micrometer diameter spots on the fundi of two adult rhesus monkeys was measured as a function of wavelength in 10 nm jumps from 400 to 900 nm. the areas measured were a retinal artery and vein, areas of the disk, macula, and retina devoid of visible blood vessels, and the foveola. the eyes of the two monkeys were then exsanguinated, the blood vessels were filled with normal saline, and reflectances of the same spots on the fundi were again measured. the pairs of reflectan ... | 1978 | 96040 |
| an ultrastructural study of subacute combined degeneration of the spinal cord in vitamin b12-deficient rhesus monkeys. | prolonged deprivation of vitamin b12 in rhesus monkeys produced changes in the central nervous system that were indistinguishable topographically and histologically from those of human subacute combined degeneration. ultrastructural studies of early lesions of the spinal cord disclosed a degeneration of myelin characterized by separation of myelin lamellae and formation of intramyelinic vacuoles, leading eventually to complete destruction of myelin sheaths. at a later stage, there was degenerati ... | 1978 | 96220 |
| functional specificity of lateral geniculate nucleus laminae of the rhesus monkey. | 1. this study investigated the functional specificity of the lateral geniculate mucleus (lgn) of the rhesus monkey using microelectrode-recording techniques. 2. the parvocellular laminae of the lgn receive input predominantly from medium-conduction-velocity optic tract fibers, while the magnocellular laminae receive fast-conducting axons from the retina. 3. cells projecting from the parvocellular layers to area 17 have medium-conduction velocities, while those from the magnocellular layers are f ... | 1978 | 96227 |
| cerebral arterial responses to induced hypertension following subarachnoid hemorrhage in the monkey. | regional cerebral blood flow (rcbf), angiographic cerebral arterial caliber, and cerebrospinal fluid (csf) pressure were measured in rhesus monkeys to determine the effect of experimentally induced subarachnoid hemorrhage (sah) on cerebral arterial responses to graded increases in blood pressure. these measurements were also performed in a control group of monkeys subjected to a mock sah by injection of artificial csf into the cerebral space. before subarachnoid injection of blood or artificial ... | 1978 | 96231 |
| pharmacokinetics of iodoxamic acid in rhesus monkey: biliary excretion, plasma protein binding, and enterophepatic circulation. | the previously reported steady-state method allowed estimation of the capacity-limited pharmacokinetics of the cholangiographic agent, iodipamide. to circumvent the long time period required to establish each steady-state level, a dynamic method was applied to the study of the rate processes involved in the hepatic uptake and biliary excretion of a new cholangiographic agent, iodoxamic acid, in rhesus monkeys. the dynamic method has the advantage that the pharmacokinetic parameters involved in c ... | 1978 | 96248 |
| hemodynamic effects of systemic and central administration of alpha-methyldopa. | systemic and regional hemodynamic changes were measured in five restained conscious rhesus monkeys before and after a 2-hour intravenous infusion of 50 mg/kg of alpha-methyldopa and, in another group of five monkeys, 5 to 10 mg injected into a lateral cerebral ventricle. both routes of administration evoked similar degrees of hypotension, bradycardia and decreased cardiac output, although the cerebral intraventricular (i.c.v.) injections had more immediate and long-lasting effects. both groups ... | 1978 | 96250 |
| photic and pentylenetetrazol-induced seizure susceptibility in macaca mulatta. | ninety-five out of 100 male macaca mulatta of varying ages from a restricted habitat in n. india showed no abnormal seizure susceptibility or eeg response to photic stimulation and no electro-clinical features of epilepsy after pentylenetetrazol, 40 mg/kg sc.c. autopsy studies on the remaining five monkeys with increased seizure proneness revealed depressed skull fractures with cortical trauma in four and a neoplasm in one. presumably, these factors were responsible for the lowered seizure susce ... | 1977 | 96259 |
| genital ureaplasmas in nonhuman primates. | ureaplasmas were isolated from the genital tracts of four of 22 (18.4%) male chimpanzees and eight of 23 (34.8%) female chimpanzees. twenty-nine female rhesus monkeys, 38 female baboons, one gibbon, and black ape and one java monkey were shown to be free of genital ureaplasmas. the rate of reproductive failure among the chimpanzees was high and it is suggested that ureaplasma may be responsible in part. the chimpanzee may serve as a useful model for human ureaplasma genital infections. | 1977 | 96260 |
| plasma amine oxidase activity in 136 normal rhesus monkeys: relationships between enzyme activity and age, sex and genetic factors. | normative data on plasma amine oxidase activity were obtained for four primate species, m. mulatta, m. arctoides, c. aethiops and h. sapiens. significant between-species differences in activity were observed. in a large sample of m. mulatta, no significant relationship between age and plasma amine oxidase activity was observed, but adult males had significantly higher enzyme activities than adult females. | 1977 | 96261 |
| comparative metabolism of the amphetamine drugs of dependence in man and monkeys. | the use of animal models to study drug dependence and tolerance requires that the species used metabolizes the drugs like man, a condition frequently not fulfilled by non-primate species. the metabolic fate of several amphetamine drugs, namely amphetamine, norephedrine, chlorphentermine and phenmetrazine, in the rhesus monkey and the tamarin and two non-primate species has been investigated and compared to that found for man. the findings show that the two primate species metabolize these drugs ... | 1977 | 96262 |
| closed needle liver biopsy for assessment of monooxygenase activity in rhesus monkeys (macaca mulatta). | closed needle liver biopsy routinely provides 60-100 mg tissue from rhesus monkeys (macaca mulatta). no mortality or morbidity was observed in over 400 needle biopsies during a two-year period in which some monkeys were biopsied over 30 times. biopsy tissue was used as enzyme source in low-volume in vitro systems for measurement of hepatic monooxygenase activity. | 1978 | 96263 |
| dysgerminoma in a rhesus monkey: morphologic and biological features. | a female macaca mulatta was observed for 31 months after the initial surgical removal of an ovarian tumor. solitary metastatic lesions were surgically removed 26 and 28 months after excision of the primary tumor. the animal was killed after 31 months because of additional metastatic lesions. histological evaluation by light microscopy was not conclusive in determining the origin of neoplasm. transmission electron microscopy, lymphocyte marker studies, and hormone assays were utilized to confirm ... | 1978 | 96265 |
| suppression of visual observing by rhesus monkeys produced by conditioned aversive visual stimuli. | nine rhesus monkeys were tested in a visual observing situation to determine the influence of conditioned aversive visual stimulation. a set of meaningless visual stimuli was selected on the basis of cumulative frequency and cumulative duration of observing during a pretest phase of the experiment. three subsets of stimuli (low, medium, high) were formed indicating level of observing during pretesting. a portion of the "medium" category of slides then served as conditioned stimuli in a classical ... | 1978 | 96417 |
| malnutrition and social isolation: learning in the developing rhesus monkey. | 1978 | 96454 | |
| comparative effects of cocaine and pseudococaine on eeg activities, cardiorespiratory functions, and self-administration behavior in the rhesus monkey. | the effects of cocaine and pseudococaine on the eegs, heart and respiratory rates, and self-administration behavior were studied in rhesus monkeys. an intravenous injection of cocaine (2.5 and 4.0 mg/kg) in the monkey produced low-voltage fast waves (lvfws) in the eegs and behavioral hyperexcitation accompanied by marked increases in the heart and respiratory rates with mydriasis and excessive salivation. in contrast, pseudococaine produced high-voltage slow waves (hvsws) in the eegs and behavio ... | 1978 | 96463 |
| a comparison of the effects of 50 mevd leads to be neutron and cobalt-60 irradiation of the kidneys of rhesus monkeys. | twenty rhesus monkeys had one kidney irradiated (after undergoing unilateral nephrectomies) with one of four doses: 960 or 1080 rads of 50 mevd leads to be neutrons, or 2350 or 2700 rads of 60co. whereas animals treated with the lower dose of neutrons or 60co are alive with relatively normal renal function, those treated with the higher dose of neutrons died of radiation nephritis. animals treated with the higher dose of 60co developed radiation nephritis but survived. the physiological and hist ... | 1978 | 96490 |
| absorption, tissue distribution and excretion of 14c ethylenethiourea by the rhesus monkey and rat. | two female rhesus monkeys and four sprague-dawley rats were give 14c ethylenethiourea by gastric intubation and the rate of excretion was evaluated for 48 hours. the animals were subsequently sacrificed and the tissue distribution of 14c determined. the major route of 14c excretion was by way of the urine with 47 and 64% of the total radioactivity in the monkey urine and an average of 82% in the rat urine. the feces accounted for less than 1.5% of the radioactivity in both animal species. tissue ... | 1978 | 96502 |
| choice behavior in rhesus monkeys: cocaine versus food. | rhesus monkeys were allowed to choose between intravenous injections of cocaine and food reinforcement for lever pressing. a choice trial was available every 15 minutes continuously for 8 days. the animals chose cocaine almost exclusively, which resulted in high cocaine intake, decreased food intake, weight loss, and marked behavioral toxicity. the study provides evidence of the reinforcing efficacy of cocaine. | 1978 | 96531 |
| seminal vesicles as organs of sperm storage. | this study was done to determine whether or not the seminal vesicles store spermatozoa. half of the nonhuman primates' vesicles had sperm at autopsy as did one of the men dying a traumatic death. seminal vesicle sperm storage may be the reason for continued spermatozoa in the ejaculates of men after vasectomy. | 1978 | 96560 |
| pituitary-adrenal response to stimulation of the limbic system and lateral hypothalamus in the rhesus monkey (macacca mulatta). | various sites within the limbic system, frontal lobe and lateral hypothalamus of the rhesus monkey brain were electrically stimulated using chronically implanted electrodes. increases in plasma cortisol was observed after stimulation of the lateral hypothalamic area, basolateral amygdala, pyriform cortex, hippocampus, certain sites in the cingulate gyrus and orbital part of the frontal lobe. inactive sites included the caudate nucleus, putamen and white matter in the frontal lobe. | 1978 | 96644 |
| the effects of intravenous sodium octanoate on the rhesus monkey. | 1978 | 96693 | |
| lipoprotein immunogenetics and atherosclerosis. | the discovery of the first human lipoprotein polymorphism by allison and blumberg [lancet i:634-637, 1961] and the availability of alloimmune sera stimulated us to begin immunogenetic studies on swine in search of lipoprotein diversity and its relationship to biological functions. we found considerable lipoprotein polymorphism, complexity, and heterogeneity in this species. these results and the correlation between immunogenetically defined lipoprotein type and arterial lipidosis in swine, fed a ... | 1978 | 96696 |
| metabolism of sulpiride in man and rhesus monkeys. | the metabolism of 14c-carbonyl-sulpiride (form a) and of 14c-3, 4 pyrrolidine-sulpiride (form b) was studied in the rhesus monkey and man. in the monkey, the metabolites in both the urine and the bile were the same with form a and form b: 60-80% sulpiride, 10-30% 5-oxopyrrolidine sulpiride and 3-8% an unidentified metabolite (me-x). in four human volunteers given a single oral dose of either 108 mg form a or 100 mg form b, more than 95% of the 14c recovered in the urine and feces was unchanged s ... | 1978 | 96745 |
| stimulation of prolactin secretion by testosterone in juvenile male rhesus monkeys. | 1978 | 96879 | |
| fetal-placental weight relationships in the rhesus (macaca mulatta). | 1978 | 96882 | |
| effect of gastrointestinal hormone infusions of lower oesophageal competence of rhesus monkeys. | the lower oesophageal high pressure zone (hpz) was studied in 5 non-refluxing and 3 refluxing rhesus monkeys. the changes in hpz and reflux status in response to infusion of various doses of secretin, cholecystokinin and glucagon were measured in all animals, and, in the 5 non-refluxing monkeys, after oesophagogastrectomy with replacement of the lower oesophagus by a stomach tube. all three hormones consistently produced a transient decrease in the hpz pressure. the only change in response follo ... | 1978 | 96906 |
| the corticopontine projection in the rhesus monkey. origin and principles of organization. | 1978 | 96910 | |
| central neuroendocrine regulation of brain water permeability. | the brain vasculature, especially capillaries, may function in a very dynamic fashion under neuroendocrine control to regulate the internal environment of the brain. this is exemplified by new observations on the regulation of brain water permeability using the tracer h215o in vivo in adult rhesus monkeys. these studies reveal that brain water permeability, and hence brain water content and volume, are, at least in part, under the influence of the central noradrenergic system and centrally relea ... | 1978 | 97063 |
| coagulation changes following vasectomy: a study in primates. | thirty vasectomized rhesus monkeys were tested for changes in coagulation factors that might reflect an increased incidence of thrombosis. the results of tests on these monkeys were compared with results of tests on 18 control rhesus monkeys; there were no significant differences between control and vasectomized animals for any of the parameters tested. one vasectomized animal had increased levels of fibrin monomer in his plasma on repeated samples, but no evidence of thrombosis on postmortem ex ... | 1978 | 97098 |
| competitive social strategies in groups of deprived and experienced rhesus monkeys. | behavior during competition for water was observed in 2 social groups of young rhesus monkeys (3 females, 3 males in each). monkeys in one group were socially deprived and those in the other were socially experienced (raised with mother and agemates). social status, based on dyadic recording of displacements at the water bottle, was predictive of a number of measures related to water consumption and social orientation in both groups, but this measure was less reliable and predictive for the expe ... | 1978 | 97110 |
| susceptibility of human cultured cells to mason-pfizer monkey virus. | mason-pfizer monkey virus (m-pmv), originally isolated from mammary carcinoma of a rhesus monkey, is infectious to various human cells in tissue culture. human epithelioid cells (hela and hep-2), fibroblastic cells (embryonic cells as well as virus-transformed embryonic rsb cells), and glial cells (kc) have all been infected with m-pmv. electron microscope studies have shown that all infected cells produce progeny virus. the titer of infectious m-pmv in cultures of hela and hep-2 cells assayed b ... | 1978 | 97115 |
| metabolism of bile acids. v . metabolism of ursodeoxycholic acid in rhesus monkey. | 1977 | 97247 | |
| entry of beta-n-oxalyl-l-alpha,beta-diaminopropionic acid, the lathyrus sativus neurotoxin into the central nervous system of the adult rat, chick and the rhesus monkey. | 1978 | 97367 | |
| the strength of the reflex response to sinusoidal stretch of monkey jaw closing muscles during voluntary contraction. | 1. rhesus monkeys were trained to exert steady biting forces of 3--60 n for 1--2 sec. this behaviour was well maintained while sinusoidal or step opening and closing movements were imposed on the jaw. 2. the amplitude of the force modulation during sinusoidal stretching was divided by the amplitude of movement to obtain the magnitude of stiffness. this estimate was made at frequencies from 2 to 50 hz at amplitudes of 100 and 500 micrometer (half the peak-to-peak movement at the incisors). 3. pea ... | 1978 | 97378 |
| functional specialisation in the visual cortex of the rhesus monkey. | anatomical and functional studies of the visual cortex of the rhesus monkey have shown that it is made up of a multiplicity of distinct areas. these seem to be functionally specialised to analyse different features of the visual environment. | 1978 | 97565 |
| gamma hydroxybutyrate in the monkey. i. electroencephalographic, behavioral, and pharmacokinetic studies. | gamma hydroxybutyrate (ghb) was administered to adult and prepubescent rhesus monkeys intravenously in varying dosages while an electroencephalogram (eeg) was recorded from scalp electrodes and the body core temperature was monitored. blood and cerebrospinal fluid samples were assayed for gamma hydroxybutyrate. ghb produced a trancelike stupor in all the monkeys, associated with marked eeg changes and hypothermia. there was a striking age specificity in that prepubescent rhesus monkeys responded ... | 1978 | 97574 |
| application of basic research data to clinical amblyopia. | the rhesus monkey has evolved as a useful model for the study of amblyopia caused by neonatal lid closure and experimental strabismus and anisometropia. in view of the behavioral and anatomic similarities of the visual system in humans and rhesus monkeys, there is reason to believe that the neurophysiologic and anatomic anomalies identified in animals as part of the "visual deprivation syndrome" occur in humans as well. animal research has led to better understanding of the basic mechanisms resp ... | 1978 | 97608 |
| electric shock delivery system for rhesus monkeys: its effect on escape responding. | the present experiment evaluated a simple chronic electric shock delivery system for rhesus monkeys restrained by a harness and arm arrangement used in experiments involving intravenous drug delivery. electric shock was delivered via two small electrodes surgically implanted in the lumbar muscle. during experimental sessions, responding on a fixed-ratio 10 schedule terminated the delivery of a train of 100 electric shock pulses and produced a 3 min timeout. a maximum of 19 trials were possible d ... | 1978 | 97676 |
| the reinforcing property of ethanol in the rhesus monkey ii. some variables related to the maintenance of intravenous ethanol-reinforced responding. | 1978 | 97716 | |
| neurotoxicity of adriamycin (doxorubicin) perfused through the cerebrospinal fluid spaces of the rhesus monkey. | 1978 | 97803 | |
| androgen metabolism in the rhesus monkey. | a mixture of 3h-testosteron (t) and 14c-4-androstene-3, 17-dione (a) was injected intravenously into 2 (i and ii) rhesus monkeys (macaca mulatta). a third monkey (iii) was injected with 3h-t only. urine and bile samples were collected at intervals for 6 hours following the injection. the excretion, conjugation and aglycone metabolites of the steroids injected were studied using these samples. of the injected dose, animal i (male) excreted 32% 3h and 23% 14c in the bile and 30% 3h and 21% 14c in ... | 1978 | 97807 |
| comparative responses of the carotid and vertebral arterial systems of rhesus monkeys to betahistine. | a newly developed photoelectric method was used in 5 rhesus monkeys to measure the mean transit time of blood through the carotid and vertebral arteries, together with measurement of the blood flow through the tissues of the fronto-parietal area supplied by the carotid artery and of the cerebellar tonsil supplied by the vertebral artery. following intravenous administration of betahistine mesylate, a histamine analog, the mean transit times of blood through the 2 arteries were equally shortened ... | 1978 | 97809 |
| origin and differentiation of the yolk sac and extraembryonic mesoderm in presomite human and rhesus monkey embryos. | reexamination of presomite human and rhesus monkey embryos in the carnegie collection provides no evidence to corroborate the hypothesis that the trophoblast is the source of all extraembryonic tissues in these embryos. instead, the present study indicates that the developmental pattern of the yolk sac and extraembryonic mesoderm is homologous to that in other eutharian mammals. the primary yolk sac of 10- to 11-day human blastocysts is partially filled with a meshwork of extraembryonic endoderm ... | 1978 | 98035 |
| menstruation in intraocular endometrial transplants in the rhesus monkey. | 1978 | 98044 | |
| spectrographic analysis of laryngeal air sac resonance in rhesus monkey. | laryngeal air sacs are circular out-pocketings, located in the hyoid bone with their ostium in the midline of the anterior part of the larynx. from previous cadaver studies of the rhesus monkey it was deduced that the function of the air sac is to act as a resonating chamber. the present study was designed to test this hypothesis. recordings were made of three rhesus monkeys before and after surgical removal of the air sac. spectrographic analysis of the monkeys' vocalizations indicated that dif ... | 1978 | 98051 |
| scaling of organ weights in macaca arctoides. | the allometric scaling of nine internal organs was examined for macaca arctoides. significant organ weight-body weight regressions were obtained for heart, lungs, kidneys, pancreas, thyroid, liver, and testes. the spleen and adrenal glands exhibited strong variability and were only loosely correlated to body weight. using allometry as a criterion of subtraction, observed sex differences in mean organ weights were seen to be primarily the result of differences in average body weight. it is postul ... | 2001 | 98058 |
| accuracy of the regulation of caloric ingestion in the rhesus monkey. | in seven male monkeys, macaca mulatta, the infusion of nutrients into the stomach just prior to or 20 h before a 4-h feeding period reduced the feeding by an amount comparable to the calories infused. pure carbohydrates, fat, protein, and mixtures were employed as infusions and given in a random fashion over a caloric range of 75-300 kcal. in a second series of experiments, monkeys were partially fasted on 1 day and in this way deprived of 75, 150, 300, or 450 kcal. on successive days, they over ... | 1978 | 98062 |
| effect of staphylococcal enterotoxin b on cardiorenal functions and survival in x-irradiated rhesus macaques. | pretreatment of rhesus macaques with nonlethal total-body x-irradiation (400 r) prolonged survival time from an average of 15 hours to 101 hours after intravenous (iv) inoculation of 50 microgram of staphylococcal enterotoxin b (seb)/kg of body weight. radiation exposure per se did not produce detectable cardiorenal changes; however, the longer survival after seb challenge exposure in x-irradiated rhesus macaques was associated with improved cardiorenal functions if compared with that of nonirra ... | 1978 | 98079 |
| antimalarial activities of various 4-quinolonemethanols with special attention to wr-142,490 (mefloquine). | pilot appraisals of the activities of a selected group of 4-quinolinemethanols against acute plasmodium falciparum infections in owl monkeys indicated that compounds of this class are equally active against infections with chloroquine-resistant and chloroquine-susceptible strains and that this efficacy is not compromised by concomitant resistance to pyrimethamine, and in addition, identified three derivatives with outstanding activity (wr-226,253; wr-142,490; and wr-184,806). wr-142,490, the sec ... | 1978 | 98104 |
| effect of salicylic acid on the percutaneous absorption of hydrocortisone. in vivo studies in the rhesus monkey. | to document the effect of salicylic acid on hydrocortisone penetration in vivo in the rhesus monkey, hydrocortisone 14c, with and without salicylic acid, was applied in acetone and the solvent evaporated. the compounds also were applied in a formulation (60% ethanol, 5% propylene glycol, 5% glycerin, 30% water) in which salicylic acid enhances penetration in vitro. there was a difference in the kinetics of hydrocortisone absorption with the two formulations. in acetone, excretion of 14c peaked a ... | 1978 | 98115 |
| [alteration of the construction and cellular composition of ileo-colonic lymph nodes of rhesus macaques after administration of salmonella vaccine]. | in stained histological sections, percentage ratio of areas to different cellular elements in structural components of the ileocolonic lymph nodes was studied in mature macaca rhesus, normal and after injection of salmonella vaccine. a rather considerable reaction in all structural components and cell composition of the lymph nodes was demonstrated as a response to immunization of the animals. these changes were demonstrated in decreased area occupied by the cortical substance and in increased a ... | 1978 | 98134 |
| effects of increased ambient co2 on brain tissue oxygenation and performance in the hypoxic rhesus. | alterations of cerebral gas tensions and performance in response to hypoxia, with or without 5% co2 in the ambient inspirate, were studied in eight conscious rhesus monkeys. the animals were trained to perform a lever press (sidman) avoidance task. physiological and performance data were obtained during exposures to normal (21% o2) and hypoxic (12, 10, and 8% o2--all with n2 balance) breathing atmospheres, with or without the addition of 5% co2. with hypoxia, cerebral po2 and pco2 declined stead ... | 1978 | 98161 |
| in vitro effects of pemphigus antibodies on skin. | acantholysis occurring in rhesus monkey skin explants cultured on sera of 9 pemphigus patients was found to be largely dependent on the titre of intercellular antibody, and not on the participation of complement. skin explants cultured on normal human sera and pemphigoid sera failed to give rise to intercullular staining or to develop lesions. six of eight 'negative' pemphigus sera with intercellular antibody titres of less than 20 on skin (and titres ranging from 20 to 160 on monkey esophagus) ... | 1978 | 98177 |
| metabolism of lead-210 in juvenile and adult rhesus monkeys (macaca mulatta). | experiments were conducted measuring the gastrointestinal absorption and elimination of a single dose of lead-210 acetate in infant and adult rhesus monkeys. urinary and fecal excretion of absorbed lead was followed for 23 days. infant monkeys eliminated less and absorbed more orally administered lead. adult animals excreted more absorbed lead in feces, while urinary excretion between adults and infants was similar. increased absorption of administered lead and reduced fecal excretion of absorbe ... | 1978 | 98188 |
| information about movements in monkeys (macaca mulatta) with lesions of dorsal prefrontal cortex. | it is not known on what information prefrontal cortex acts. since it has been suggested that it might operate on information about movements, rhesus monkeys were trained on a counting task testing memory for movements. they had to tap a key until a light went out and then repeat, either immediately or after a delay, the number of presses they had made. monkeys with lesions of dorsal prefrontal cortex were impaired on this task, unlike monkeys with lesions of sulcus principalis alone. cortex on t ... | 1978 | 98214 |
| species variability in plasma s-sulfonate levels during and following sulfite administration. | it has been shown that s-sulfonate compounds (r-s-so-3) are produced by the action of sulfite on reactive disulfide bonds [4,5]. plasma s-sulfonate production was determined as a function of sulfite ingestion and intraperitoneal injection in rats, mice and rhesus monkeys. the tendency of these species and of the rabbit [8] to produce s-sulfonates in plasma was related to the availability of sulfite and of reactive disulfide bonds and to the stability of plasma protein s-sulfonates. the rhesus mo ... | 1978 | 98238 |
| enterotoxic shock in rhesus monkeys. the role of selected bloodborne factors. | 1978 | 98239 | |
| nature of immune complexes formed in rhesus monkeys immunized with pr-beta-hcg-tt on challenge with hcg. | 1978 | 98290 | |
| immunofluorescence and electron microscopic studies on kidney, choroid plexus and pituitary in rhesus monkeys immunized with the anti-hcg vaccine pr-beta-hcg-tt. | 1978 | 98291 | |
| the handedness of rhesus monkeys: ii. concurrent reaching. | of 171 monkeys tested for handedness, 60 were found to make occasional bilateral concurrent reaches. these reaches accounted for only 1.3% of the total of 600 reaches observed for each animal. younger animals were observed to make such reaches more frequently than older animals. concurrent reaching was characterized by a lower degree of preference for the overall preferred hand than unilateral reaches made by the same animals at comparable periods of testing. | 1978 | 98292 |
| appearance of eeg changes reminiscent of a secondary generalized epilepsy in a rhesus monkey inoculated with a strain of kuru. | in a group of rhesus monkeys (macaca mulatta) inoculated intracerebrally and intravenously with a strain (enage strain rhesus l6 56) of kuru already passaged in rhesus monkeys, 1 monkey presented the typical eeg pattern of epileptogenic encephalopathy reminiscent of the lennox-gastaut syndrome. this observation provides no direct evidence for the viral origin of epilepsies of this type. it does, however, show that it is possible to induce an epileptogenic encephalopathy by an unconventional infe ... | 1978 | 98316 |
| single unit responses in the inferior colliculus of the awake and performing rhesus monkey. | 1. the activity of single units in the inferior colliculus of unanesthetized monkeys was recorded during performance in an auditory reaction time task. stimulus intensity and frequency were varied. 2. spontaneous rate of unit discharge varied from 0 to 78.2 discharges per second, with a mean of 14.7 discharges/sec. 3. both broadly and narrowly tuned units were encountered in the central nucleus of the inferior colliculus. the temporal discharge pattern of most units varied with changes in stimul ... | 1978 | 98341 |
| preliminary studies of plasma growth hormone releasing activity during medical therapy of acromegaly. | the in vitro growth hormone releasing activity of plasma obtained from six acromegalic subjects was measured before and during therapy. in five subjects, plasmas were obtained before and during successful medical therapy with medroxyprogesterone acetate (mpa). the sixth subject was sampled before and after transphenoidal sr90-induced hypopituitarism. all subjects had a decrement in fasting growth hormone levels with respective therapies (29-88%). the in vitro growth hormone released from rhesus ... | 1978 | 98420 |
| effect of low dose norethindrone acetate released through subdermal silastic implant on lipid metabolism in female rhesus monkeys. | 1978 | 98430 | |
| comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of rhesus monkeys. | 1978 | 98439 | |
| anterior chamber volume determination in the rhesus monkey. | 1978 | 98472 | |
| effects of various types of separation experience on rhesus monkeys 5 months later. | 1978 | 98534 | |
| immunization with dextransucrases, levansucrases, and glycosidic hydrolases from oral streptococci. ii. immunization with glucosyltransferases, fructosyltransferases, and glycosidic hydrolases from oral streptococci in monkeys. | the feasibility of immunizing monkeys with enzymes from oral streptococci in an attempt to reduce dental caries was investigated. forty rhesus monkeys, macaca mulatta, were used. cariogenic streptococci, s mutans, were implanted into all the monkeys' mouths. there was no pathological effect resulting from immunization. of the 40 animals, 30 retained the implanted flora throughout the experiment; the remaining 10 were reimplanted until the streptococci remained. in six months, gross carious lesio ... | 1977 | 98540 |
| the bilateral response of the temporal muscle in the rhesus monkey (macaca mulatta) to short-term detachment of the muscle and increased loading of the mandible. | the electromyographic background activity of the temporal muscle was observed after short-term detachment of the muscle and with increased loads on the mandible. detachment of the muscle increased its mean spike discharge within the first 24 days but without significant changes in the spectral components. loading the mandible decreased both the spike discharge and spectral components. | 1977 | 98541 |
| an experimental study of the central gustatory pathways in the monkey, macaca mulatta and cercopithecus aethiops. | 1. the cortex at the base of the central fissure, that is the fronto-parietal operculum, represents primary sensory receptive cortex for gustatory modalities. 2. this primary receptive cortex for taste is linked to the anterior island of reil by short inter- and intracortical association fibers. thus the anterior island is a gustatory association area involved in the subjective recognition of gustatory modalities. 3. the nucleus ventralis posteromedialis pars parvocellularis of the dorsal thalam ... | 1978 | 98582 |
| alterations of body fluid compartments and distribution of tissue water and electrolytes in rhesus monkeys with rocky mountain spotted fever. | chair-restrained rhesus monkeys (macaca mulatta) were inoculated subcutaneously with 10(2)--10(3) plaque-forming units of virulent rickettsia rickettsii. the latent period for fever and rickettsemia was three to four days; death occurred six to eight days after infection. total circulatory electrolyte levels and fluid volumes, including plasma, red blood cell, true circulatory blood, and extracellular fluid, increased. the expansion of the extracellular and plasma volumes resembled findings repo ... | 1978 | 98595 |
| model for disseminated intravascular coagulation: bacterial sepsis in rhesus monkeys. | dic is a hemorrhagic syndrome frequently encountered as a complication in severe gram-negative bacterial sepsis. an animal model for sepsis-associated dic was developed in order to permit study of the appearance and development of this syndrome in relation to the entire disease process. rhesus monkeys (4 to 6 kg) were infected by intravenous injection of 10(9) salmonella typhimurium organisms and studied for a period of 7 to 10 days following infection. ten of 23 infected monkeys developed petec ... | 1978 | 98603 |
| aerosolized antigen dose-response studies in asthmatic monkeys. | this study used rhesus monkeys which had consistent respiratory responses to a standard (single dose) aerosolized concentration of a. beginning at lower concentrations of a which did not produce an airway response, fourfold increases in concentrations of a were aerosolized until an airway response occurred. compared with the single-dose sac after the tac, some consistently reactive animals did not respond to the sac, the maximal concentration of a used for testing. thus the tac may result in an ... | 1978 | 98604 |
| circadian variations in cortisol concentrations in the plasma of female rhesus monkeys. | 1978 | 98605 | |
| in vivo distribution of carbon-11 phenytoin and its major metabolite, and their use in scintigraphic imaging. | curie quantities (0.3--1.5 ci) of h11cn were used in the synthesis of c-11-tagged phenytoin (c-11.dph) and 5-(p-hydroxyphenyl)-5-phenylhydantoin (c-11.hpph), using a modified bücherer-bergs reaction. the h11cn was produced from a mixture of 95% nitrogen and 5% hydrogen by a 45-min bombardment with 10-mev protons at 10 mua. following i.v. infusions of c-11 dph (13.7 mg/kg at a rate of 29 mg/min) into the left femoral vein of rhesus monkeys, dph shows persistent concentration in the brain and live ... | 1978 | 98619 |
| facial growth after condylectomy and alloplastic condylar replacement. | condylectomy or condylectomy with immediate alloplastic condylar replacement was performed in six young and six adult rhesus monkeys to investigate the role of the mandibular condyl in facial growth. the experimental findings support the hypothesis that the condyle does not have a primary influence on mandibular growth and that alterations in biomechanics are mainly responsible for the observed alterations in mandibular morphology after condylectomy. | 1978 | 98620 |
| effects of enteral and parenteral nutrition on appetite in monkeys. | varied clinical observations of the presence of either hunger or anorexia during intragastric or intravenous alimentation have led to the current experiments. nine rhesus monkeys (macaca mulatta) were involved in studies of the long-term effects of enteral and parenteral nutrition on appetite as assessed by feeding behavior and gastric motility. the monkeys received either intragastric infusions of glucose or a complete liquid diet, or intravenous infusions of glucose or glucose/amino acid solut ... | 1977 | 98652 |
| observations on acute gastric dilatation in nonhuman primates. | in the years 1967-1977 we diagnosed 23 cases of acute gastric dilatation in monkeys. fourteen of these animals were macaca mulatta, five macaca fascicularis, and one each of macaca nemestrina, aotus trivirgatus, saimiri sciureus, and colobus guereza. fourteen of the animals were males, nine were females, and all were adults or subadults. mortality was 78% (18 of 23 animals). thirteen of the animals had received on anesthetic, immobilizing, or tranquilizing drug 1-2 days before developing acute g ... | 1978 | 98666 |
| experimental injury of the optic nerve with optic disc swelling. | an ultrastructural study utilizing horseradish peroxidase was performed to determine the mechanism and consequences of leakage of vascular protein following injury of the optic nerve. unilateral optic nerve injuries were produced in four rhesus monkeys by making a cautery lesion on the retrobulbar portion of the optic nerve. optic disc changes were followed with stereo fundus photography and fluorescein angiography. three to 14 days after injury horseradish peroxidase was given intravenously and ... | 1978 | 98667 |
| chronic ventricular cerebrospinal fluid sampling, drug injections, and pressure monitoring using subcutaneous reservoirs in monkeys. | animal models enabling reliable access to ventricular cerebrospinal fluid (csf) are crucial to the study of neuropharmacological and neurotoxicological effects of cytotoxic agents used to treat central nervous system neoplasms. this investigation concludes that 4th ventricular catheterization using subcutaneous csf reservoirs in rhesus monkeys: (a) provides chronic access to sterile csf without chronic immobilization, (b) enables mixing of injected drugs with lateral ventricular csf, (c) permits ... | 1977 | 98727 |
| the effects of sodium nitroprusside and trimethaphan camsylate on cerebral blood flow in rhesus monkeys. | hemispheric cerebral blood flow was measured in the rhesus monkey before and after infusion of the hypotensive agents sodium nitroprusside and trimethaphan camsylate. the intracarotid injections of 133xe was utilized, and flow was calculated by the "flow initial" technique. cerebral blood flow did not change significantly with the administration of trimethaphan camsylate. however, with a small reduction in blood pressure (10.6%) during the administration of sodium nitroprusside, the cerebral blo ... | 1978 | 98729 |