Publications

atropine inhibition of echothiophate cataractogenesis in monkeys.	one cynomolgus and three vervet monkeys were treated topicall twice daily in one eye with 63 microgram of echothiophate iodide and 750 microgram of atropine sulfate. the opposite eyes were treated with echothiophate alone. the eyes treated with echothiophate alone all developed posterior and/or anterior subcapsular cataracts within 26 to 66 days. the echothiophate plus atropine-treated cynomolgus eye developed a cataracts of much delayed onset and lesser severity compared to its echothiophate-on ...	1977	406884
subsurface cisterns in the cynomolgus retina.	subsurface cisterns were found in retinal neurons of the cynomolgus monkey. they were located in amacrine, bipolar and ganglion cells and were associated with the rough endoplasmic reticulum. subsurface cisterns were not found in müller cells. the possible functional significance of the subsurface cisterns is discussed.	1977	407003
respiratory pathogens in non-human primates with special reference to corynebacterium ulcerans.	an investigation of 272 non-human primates (75 macacca cynomolgus, 97 macacca mulatta and 100 cercopithecus aethiops) revealed a high incidence of respiratory disease caused by corynebacterium ulcerans, staphylococci, diplococci and streptococci. escherichia coli was also found as a secondary invader. most of the infections occurred during winter in macaca cynomolgus and were caused by corynebacterium ulcerans and diplococcus pneumoniae. the c. ulcerans strains were phage type vi g. a phage typ ...	1977	407395
differences in the virulence of plasmodium knowlesi for macaca irus (fascicularis) of philippine and malayan origins.	this report summarizes the results of a comparative study of the virulence of the "s-m," h, and c strains of p. knowlesi for indian rhesus monkeys (macaca mulatta) and cynomolgus monkeys [m. irus (fascicularis)] of malayan (west malaysia) and philippine origins. each of the above strains produced fulminating, uniformly fatal infections in the rhesus monkey and mild, chronic infections, characterized by relatively low level parasitemias in cynomolgus monkeys of philippine origin. in striking cont ...	1977	407808
application of freeze-dried monkey erythrocytes to measles viral hemagglutination and hemagglutination-inhibition tests.	erthrocytes collected from monkey species including grivet, rhesus, and cynomolgus monkeys were stabilized by fixation with glutaraldehyde of a low concentration and were freeze-dried in vacuo. these freeze-dried erythrocytes were compared with fresh erythrocytes for measles viral hemagglutination and hemagglutination inhibition and could be used in both tests instead of fresh erythrocytes. they maintained their initial appearance and sensitivity to measles viral hemagglutinins after storage at ...	1977	408375
composite pattern of circulating lh, fsh, estradiol, and progesterone during the menstrual cycle in cynomolgus monkeys.		1977	408814
the pathophysiology of induced sah in the spontaneously breathing cynomolgus monkey using different volumes of fresh autogenous blood.		1977	409070
the enzyme-linked immunosorbent assay and its application to parasitic infections.	the enzyme-linked immunosorbent assay (elisa) was used for the serodiagnosis of four parasitic infections. elisa was performed as a macromethod in polystyrene tubes and/or as a micromethod in polystyrene microplates. conventionally raised pigs were infected orally with different numbers of trichinealla spiralis larvae, and the pigs' sera were tested for antibody to t. spiralis. results were compared with those from sera of uninfected conventionally raised pigs. cynomolgus monkeys were infected o ...	1977	409790
a new paramyxovirus isolated from cynomolgus monkeys.	a new virus was isolated from cynomolgus monkeys for laboratory use imported from indonesia in july, 1973. the virus agglutinated erythrocytes of some avian and mammalian species and hemolyzed chick erythrocytes. the virus was eluted from the surface of chick red blood cells by its neuraminidase activity. the virus was inactivated by ether; its nucleic acid was rna. on electron micrographs, the particles varied from 250 to 400 nm in diameter, being covered with envelopes in which the surface pro ...	1977	409868
a comparison of neurovirulence of vaccinia virus by intrathalamic and/or intracisternal inoculations into cynomolgus monkeys.		1977	409906
exit sites of uveoscleral flow of aqueous humor in cynomolgus monkey eyes.		1977	410651
heart mitochondrial metabolism after feeding herring oil to rats and monkeys.	heart mitochondrial oxidation of palmityl coa and pyruvic acid was studied in rats and in the monkey macaca fascicularis to determine the effects of feeding partially hydrogenated herring oil. herring oil glycerides contain cetoleic acid (cis-11-docosenoic) which could have a similar effect to erucic acid (cis-13-docosenoic) in causing a rat cardiomyopathy. the initial rat heart mitochondrial response to dietary cetoleic acid (67% cis, 33% trans) was an in vitro decrease in palmityl coa oxidatio ...	1977	411003
the effect of hemorrhagic shock and resuscitation on regional blood flow in cynomulgus monkeys.	the effect of hemorrhagic hypotension and resuscitation on regional blood flow was studied in the macaca fascicularis monkey. the majority of the splanchnic vasculature demonstrated a profound decrease in flow. following fluid expansion and correction of acidosis, flow increased in these circulations but did not reach control values. exceptions were the small bowel flow which fell only moderately and hepatic arterial flow which did not significantly change. both coronary and adrenal circulations ...	1977	411605
a direct ventral connection between the bed nucleus of the stria terminalis and the amygdaloid complex in the monkey (macaca fascicularis).	a direct ventral connection, between the bed nucleus of the stria terminalis and the amygdaloid complex in the monkey is described. it consists of bundles of extremely fine unmyelinated axons of a median diameter between 0.16 and 0.2 micrometer. the total number of axons is estimated at over 500,000. using observations gained by other authors it is deduced, that the direction of conduction is probably from the bed nucleus of the stria terminalis to the amygdala. other observations in the literat ...	1977	411830
serum estradiol and progesterone during pregnancy and the status of the corpus luteum at delivery in cynomolgus monkeys (macaca fascicularis).	levels of estradiol and progesterone in peripheral serum of seven cynomolgus monkeys (macaca fascicularis) were measured from about the 30th day of pregnancy until parturition. although the pattern of each steroid in circulation differed somewhat from the respective patterns in rhesus monkeys (macaca mulatta), there were basic similarities. on the day of delivery, the corpus luteum was excised and in vitro incubation of dispersed luteal cells was performed. isolated luteal cells produced progest ...	1977	412283
metabolism of arylacetic acids. 1. the fate of 1-naphthylacetic acid and its variation with species and dose.	1. [carboxy-14c]-1-naphthylacetic acid has been administered to man, 6 primate species and 4 other mammalian species and the urinary metabolites examined by radiochromatogram scanning and reverse isotope dilution. animals all received a dose of 100 mg/kg and man received 5 mg, orally. 2. most species excreted at least 60% of the 14c in the urine in 48 h. unchanged acid was a minor (0-17% dose) excretion product in all species except the cynomolgus monkey (35%). 3. in man, in 24 h 95% of 14c was ...	1977	412330
the organization of agonistic relations within two captive groups of java-monkeys (macaca fascicularis).	the paper offers a detailed quantitative descripition of the distribution of agonistic activities over the members of two groups of java-monkeys (macaca fascicularis). these groups lived in captivity and were well-established: i.e. they had an extensive network of genealogical relationships. the study pays special attention to agonistic interactions with three or more participants. its main purpose is an analysis of the way dyadic agonistic relations (e.g. dominance relations) are affected by th ...	1977	412345
alpha1-antitrypsin polymorphism in malaysian macaca irus.	alpha1-antitrypsin types were determined in 200 individual specimens of malaysian macaca irus. we found the pattern b in 76 samples, bc in 116, and c in 8. assuming that these patterns are determined by codominant alleles at one locus, this distribution constitutes a significant (p less than 0.001) deviation from hardy-weinberg equilibrium, because of an excess of bc and low prevalence of c. we found no clear evidence for the presence of alpha1-antitrypsin deficiency comparable to the situation ...	1977	412492
effect of cytochalasin b on conventional drainage of aqueous humor in the cynomolgus monkey.		1977	412695
experimental pulpitis in immunized monkeys.	bovine serum albumin (bsa) was topically applied to exposed dentin to assess whether inflammatory reactions can be induced in the pulp of monkeys immunized against bsa. four cynomolgus monkeys received repeated injections of bsa emulsified with freund's incomplete adjuvant. pulp challenge was performed by applying bsa in freshly cut dentin cavities prepared on the buccal surface in 34 teeth. in 29 control teeth ovalbumin (ova) was applied. control applications of bsa were also performed in 15 te ...	1977	413185
metabolism of 15-methyl-prostaglandin f2alpha in the cynomolgus monkey and the human female.		1977	413545
projections from the primary somatosensory cortex to basal ganglia and thalamus in the monkey.	radioactive amino acids were injected into the postcentral cortex (areas 3, 1 and 2) in 6 monkeys (macaca fascicularis). fibers were traced to the ipsilateral putamen, to olszewski's n. ventralis posterior lateralis pars caudalis, n. ventralis posterior medialis and inferior, to n. pulvinaris oralis, n. suprageniculatus and corpus geniculatum mediale pars magnocellularis. furthermore, there were faint postcentral projections to claustrum, n. caudatus, n. centralis lateralis, n. centrum medianum, ...	1977	413731
measurement of hemolytic complement and the third component of complement in nonhuman primates.	complement, determined by hemolytic assay, and the third component of complement (c3), determined by radial immunodiffusion assay, were measured in nine nonhuman primate species. the species studied were the titi (callicebus mollach). the sooty mangabey (cercocebus atys), the thick-tailed galago or bushbaby (galago crassicaudatus panganiensis), the crab-eating monkey (macaca fascicularis), the rhesus monkey (macaca mulatta), the bonnet monkey (macaca radiata), the stumptailed macaque (macaca spe ...	1977	414024
ornithine decarboxylase activity in tooth surface plaque from monkeys (macaca fascicularis) fed pyridoxine, phytate and invert sugar.		1977	414701
rat lung hyper-reactivity to stress.	rats have been used frequently as a model for determining the pulmonary response to various stressful situations. it has been shown in the literature that rat lungs are remarkably sensitive to factors which result in the development of gross pulmonary injury, such as stress from exposure to hyperbaric oxygen. similarly, a high degree of pulmonary reactivity was found in rats after administration of various cns, convulsants and also exposure to mechanical vibration. the present study was confined ...	1978	414726
the enamel--dentine junction of human and macaca irus teeth: a light and electron microscopic study.	the enamel--dentin junction of human and macaca irus teeth has been studied using light and scanning and transmission electron microscopy. there are differences between species and within the same tooth. scalloping, when present, is more developed in the cuspal areas and approximally, and the scallops appear to be formed at the time of maturation of the hard tissues. enamel tufts and spindles are briefly discussed. the depth of scallops was less in the human deciduous than in the permanent teeth ...	1978	415029
morphologic effects of dietary plant and animal lipids rich in docosenoic acids on heart and skeletal muscle of cynomolgus monkeys.	cynomolgi (macaca fascicularis) were fed diets containing 25% rapeseed oil (rso), partially hydrogenated herring oil (phho), or a 3:1 mixture of lard and corn oil as control for 4 months. the rso contained approximately 25% of the fatty acids as erucic acid; the phho contained a similar concentration of mainly cetoleic acid. the control diet did not include such fatty acids. at the time of necropsy, the rso- and phho-fed monkeys showed myocardial and skeletal muscle lipidosis. foci of mononuclea ...	1978	415615
north borneo (malaysia): a new locality for schistosoma japonicum.	eleven pairs of schistosomes, indistinguishable from the classical schistosoma japonicum, were found in a monkey (macaca fascicularis) taken near ranau in north borneo. the new locality is within the recorded range of the species which extends from japan, china, taiwan, and philippines through southeast asia to the celebes.	1978	415627
angiochemical and tissue cholesterol changes of macaca fascicularis fed an atherogenic diet for 3 years.		1970	415900
effects of plant and animal lipids rich in docosenoic acids on the myocardium of cynomolgus monkeys.	cynomolgus monkeys (macaca fascicularis) were fed diets containing 25% rapeseed oil (rso), partially-hydrogenated herring oil (phho) or a 3:1 mixture of lard/corn oil as control (con) for 4 months. the rso contained approximately 25% of the fatty acids as erucic acid (cis-docos-13-enoic, 22:1w9) while the phho contained a similar concentration of mainly cetoleic acid (cis-docos-11-enoic, 22:1w11). the con contained no 22:1 acids. the monkeys developed the expected myocardial lipidosis, somewhat ...	1978	416402
blood groups of pig-tailed macaques (macaca nemestrina).	the human-type a-b-o blood groups of 57 pig-tailed macaques (macaca nemestrina) were determined and the calculated gene frequencies, o = 0.8908, a = 0.0825 and b = 0.0267, gave excellent fit with the hypothesis of inheritance by triple allelic genes. in tests for simian-type blood groups with rhesus, baboon and crab-eating macaque immune antisera, it was shown that the red cells of pig-tailed macaques are polymorphic for several simian-type specificities defined by those cross-reacting sera. pig ...	1978	416724
[fluorescence histochemical studies on the monoamine-containing neurons and their pathways in the brain stem of the java monkey (macaca irus)--stereotaxic demonstration of the localization (author's transl)].		1977	416765
surface processes of olfactory receptors.	the free surface morphology of olfactory receptor cells from the nasal mucosa of cynomolgus monkeys was studied electron microscopically. the receptor cell, in addition to showing characteristic cilia, possess several branched or unbranched shorter elevations or spiny processes covered by numerous delicate lace-like filaments not previously described. these filaments diminish in length and number toward the base of the microvillous protrusions.	1978	416912
static lung mechanics of intact and excised rhesus monkey lungs and lobes.	subdivisions of lung volume and pressure-volume (pv) curves of the lung and chest wall (cw) were measured in 12 rhesus monkeys (macacca mulatta) under pentobarbital anesthesia. in addition, volumes and pv curves were obtained on the excised lungs and lobes of 12 cynomolgus monkeys (m. fasicularis). boyle's law was used to determine functional residual capacity (frc) in the intact animals and water displacement to determine minimal volume (mv) in the excised lungs. total lung capacity (tlc = lung ...	1978	417053
[the importance of interferon for rabies prophylaxis (author's transl)].	the importance of interferon for the prophylaxis of rabies is not yet fully understood. about 50% of cynomolgus monkeys infected with rabies virus could be protected from the disease with human interferon which was administered at a total dose of 1--10 million units per animal either intramuscularly 24 hours after infection or by intralumbar injection up to 11 days after. the clinical relevance of the findings is discussed.	1978	417241
prevention of hypercholesterolemia in monkeys (macaca fascicularis) by digitonin.	digitonin mixed in the diet was well tolerated by rats and cynomolgus monkeys (macaca fascicularis), and prevented the expected rise in plasma cholesterol in monkeys fed a diet containing butter and cholesterol. both digitonin and mildly hydrolyzed digitonin precipitated cholesterol dispersed in micellar suspensions and decreased intestinal absorption of cholesterol in rats, but only digitonin bound cholesterol in vitro. the hypocholesterolemic effect of digitonin may be secondary to decreased i ...	1978	417616
effects of ischemia on the oxygen diffusion coefficients in the brain cortex (studies on macaca irus).	in this series of experiments changes in oxygen diffusion coefficients were measured in waking primates undergoing focal middle cerebral artery ischemia; ligation of the middle cerebral artery followed by a decrease of the oxygen diffusion coefficient in the areas supplied by that vessel to levels ten to twenty per cent below normal by twenty-five minutes following onset of ischemia. following release and re-perfusion diffusion coefficient gradually increases and reaches a super normal peak valu ...	1977	418626
anticholinesterase-induced cholinergic subsensitivity in primate accommodative mechanism.	i treated cynomolgus monkeys with topical echothiophate iodide twice daily for several months. accommodative responses to topical or intramuscular pilocarpine were determined after ciliary ganglion or cholinergic nerve blockade. during echothiophate treatment, there was little or no accommodative response to intramuscular pilocarpine doses which were near maximal in nonechothiophate-treated eyes. similarly, echothiophate-treated eyes demonstrated little or no response to topical pilocarpine dose ...	1978	418688
craniofacial adaptations after total maxillary osteotomy in macaca irus: a cephalometric and histologic study.	five macaca irus monkeys were used in this study to determine cephalometric and histologic changes after total maxillary impactions. in the three experimental animals, the maxilla was impacted 5 to 7 mm. and lateral cephalograms were taken over a 150-day period. by superimposing on craniofacial implants, osseous and dental changes were measured. excellent skeletal stability was demonstrated during the postoperative period. histologically, there was normal osseous healing of the osteotomized maxi ...	1978	418689
carcinogenic and other adverse effects of procarbazine in nonhuman primates.	the carcinogenic potential of procarbazine is under investigation in three species (macaca mulatta, macaca fascicularis, and cercopithecus aethiops) of nonhuman primates. a total of 55 monkeys have received procarbazine s.c., p.o., or i.p. for periods of up to 12 years. eleven of the 42 monkeys (26%) necropsied thus far have had malignant neoplasms, 6 of which were acute leukemia. two monkeys developed osteogenic sarcomas, two monkeys developed hemangiosarcomas, and a single case of lymphocytic ...	1978	418874
between-ovary interaction in the regulation of follicle growth, corpus luteum function, and gonadotropin secretion in the primate ovarian cycle. i. effects of follicle cautery and hemiovariectomy during the follicular phase in cynomolgus monkeys.		1979	436777
experimental analysis of temporomandibular joint reaction force in macaques.	mandibular bone strain in the region immediately below the temporomandibular ligament was analyzed in adult and sub-adult macaca fascicularis and macaca mulatta. following recovery from the general anesthetic, the monkeys were presented food objects, a wooden rod, or a specially designed bite-force transducer. bone strain was recorded during incisal biting and mastication of food, and also during isometric biting of the rod and/or the transducer. the bone strain data suggest the following: the m ...	1979	532828
erythroblastosis models. ii. materno-fetal incompatibility in chimpanzee.	erythroblastosis fetalis represents a significant hazard for successful management of pregnancy in man and in marmosets, but not in crab-eating macaques. materno-fetal blood group incompatibility in chimpanzee is described as a contributing factor in the death of an infant. the findings indicate that parental blood groups should be taken into consideration when breeding chimpanzees.	1977	556709
nursery rearing of infant monkeys (macaca fascicularis) for toxicity studies.	at birth, nine infant male cynomolgus monkeys (macaca fascicularis) weighed an average of 402 g and 16 infant female cynomolgus monkeys weighed an average of 362 g. both female and male infants last 15-20 g by the fourth day after birth. female and male infants showed a growth rate of approximately 4 and 5 g body wt/day, respectively, from 4 to 150 days of age. caloric intake increased from approximately 140 cal/gkg body weight/day in both females and males on the first day after birth to peak v ...	1977	557707
the electrocardiogram of macaca fascicularis.	electrocardiograms from 16 male cynomolgus monkeys (macaca fascicularis) were studied. standard and augmented limb leads (i, ii, iii, avr, avl, avf) were obtained with the animals restrained in a sitting position. normal electrocardiographic parameters were determined, including pr and qt intervals; p, qrs, and t wave axes; p and qrs wave widths. voltages in all standard and augmented limb leads were lower than previously reported for similar size monkeys.	1978	642439
the c-wave of the human electroretinogram in central retinal artery occlusion.	the pigment epithelium-receptor complex, which is supplied from the choroidal circulation, is the main source of the c-wave of the erg. occlusion of the central retinal artery (ocra), which causes serious damage to the inner retinal layers, should therefore not primarily be expected to affect the c-wave amplitude. nevertheless, conflicting reports of increased, decreased and unchanged c-waves have appeared in the literature. in the present study on four patients with ocra the affected eyes showe ...	1978	696268
intrauterine ethanol-induced termination of pregnancy in cynomolgus monkeys (macaca fascicularis).	the effectiveness of locally applied ethanol in terminating early pregnancy in cynomolgus monkeys was studied. in a randomized trial ethanol (70 per cent, 1 ml.) or saline (0.9 per cent, 1 ml.) was injected extra-amniotically through a sterile blunt-end needdle inserted through the cervix into the uterine cavity. six of seven monkeys receiving ethanol showed vaginal bleeding beginning one or two days after treatment. with the one failure, alcohol leakage occurred from the luer-lock needle joint ...	1978	717489
t-strain mucoplasmas and reproductive failure in monkeys.	t-strain mycoplasmas were isolated from the genital tracts of 3 genera of female monkeys: the talapoins, miopithecas talapoin, the patas, erythrocebus patas, and the macaques, macaca fascicularis. the talapoins have not reproduced successfully for the past 2 yr. fertility in the patas has also been reduced, with a high incidence of stillbirths and spontaneous abortions. the macaques were not permitted to breed.	1975	805883
the application of qae-sephadex for the purification of two staphylococcal enterotoxins. ii. purification of enterotoxin a.	the last three steps described in the preceding communication robern, h., stavric, s. and dickie, n. (1975) biochim. biophys. acta 000,000-000) were utilized successfully for the purification of enterotoxin a. the enterotoxin appeared homogeneous by gel chromatography and in the analytical ultracentrifuge but showed two bands on polyacrylamide disc electrophoresis at ph 4.5. the emetic dose, ed50, by intravenous route in cynomolgus monkeys was 0.12 mug/kg of animal weight. after treatment with b ...	1975	806302
effect of sodium phytate on the chemical and microbial composition of dental plaque in the monkey (macaca fascicularis)	the incorporation of 1 or 3% sodium phytate in confectioners sugar produced minimal changes in the physical,chemical, and microbial composition of dental plaque in tube-fed monkeys during a two-week period. only a reduction in yeasts and lactobacilli could be ascribed to the presence of phytate. other changes were attributable to the transition from conventional feeding to tube-feeding, irrespective of the presence of absence of phytate.	1975	806617
the influence of 2 br-alpha-ergocryptine (cb-154) and apomorphine on induced prolactin secretion in the crab eating monkey (macaca fascicularis).	the influence of apomorphine and 2 br-alpha-ergocryptine (cb-154) on drug-induced prolactin secretion was examined in an intact and an ovariectomized monkey (macaca fascicularis). perphenazine administered iv at one mg/kg bw induced a rapid and marked increase in serum prolactin. apomorphine at a concentration of 4 mg/kg bw administered prior to perphenazine delayed the perphenazine-induced prolactin rise. the iv administration of cb-154 at either 200 or 2000 mu-g/kg bw completely blocked the pe ...	1975	807469
sulphated macromolecules in dental plaque in the monkey macaca irus.		1975	808203
experimental oroparanasal communication in monkeys.	experimental oroparanasal communications were established in nine monkeys (macaca irus) through the alveoli of the maxillary first or second molars after extraction of these teeth. the communications between the maxillary sinus and the oral cavity were supported by use of a polyethylene catheter fixed with sutures. the observation time ranged from 1 to 6 days. histologic study of the maxillary sinus mucous membrane revealed inflammatory changes especially in the floor and the lower part of the w ...	1975	808503
erythroblastosis models. a review and new experimental data in monkeys.	the current status of erythroblastosis fetalis in man and in animals is briefly reviewed with emphasis on present knowledge of nonhuman primates as models for the disease. our studies in crab-eating macaques indicate that presence in a mother's serum of potent antibodies reactive for red cells for her fetus will not necessarily cause erythroblastosis; in one case the maternal antibodies did not penetrate the placental barrier, and in two cases although the fetal red cells were maximally antibody ...	1975	808623
treatment of squamous cell carcinoma involving the buccal pouch in a crab-eating macaque.	persistent swelling of the left buccal pouch was noticed in an adult female crab-eating macaque (macaca fascicularis). a mass involving almost the entire musculature of the pouch was removed surgically. the histopahtologic diagnosis was squamous cell carcinoma. recurrence of the mass was treated by a combination of surgical excision and radiation therapy.	1975	809400
maximum expiratory flow-volume studies on monkeys exposed to bituminous coal dust.	to assess early ventilatory responses at the 2 mg/m3 bituminous coal dust standard, 23 cynomolgus monkeys were exposed by inhalation to pennsylvania and utah coal dust. ten controls were utilized. pennsylvania coal was selected from a field having a high prevalence of coal workers' pneumoconiosis while the utah coal was selected from a low prevalence area. after 24 mo of exposure, a pattern of pulmonary impairment consistent with peripheral airway obstruction was demonstrated. reductions were ob ...	1975	809410
[retinal reactions to intense light. i. threshold lesions. experimental, morphological and clinical studies of pathological and therapeutic effects of laser and white light].	the effects of intense light produced by an argon laser, a helium-neon laser and a xenon are photocoagulator in the retinas of gray chinchilla rabbits, cynomolgus monkeys, and rhesus monkeys were studied clinically and histopathologically including electron microscopy. an improved experimental set-up was used allowing a very good consistency of the inflicted lesions. threshold lesions were produced in chinchilla rabbits and cynomolgus monkeys by an argon laser and a helium-neon laser. the lesion ...	1975	810008
sinusoidal flicker characteristcis of primate cones in response to heterochromatic stimuli.	electrophysiological recordings of primate photorecptors have been obtained and frequency response characteristics of the red, green and blue cones have been determined and compared to previous psychophysical findings. using cynomolgus monkeys, we recorded the foveal local electroretinogram, which is dominated by the late receptor potential, and obtained criterion-response threshold data for sinusoidally flickered test stimuli complementary chromatic adapting backgrounds. our results support the ...	1975	810550
effective body water half-life and total body water in rhesus and cynomolgus monkeys.	although body water content and effective water half-life have been determined in several mammalian species, including man, these measurements are not available for sub-human primates to our knowledge. values were therefore determined in a group of rhesus and cynomolgus monkeys. a fairly wide range of water half-life values was found in each of the two species between animals, but there was little variation within animals who had more than one determination over the course of 1 year. mean values ...	1975	811339
[changes in cellular activity in corpus luysi after stimulation of monkey corpus striatum].	in a chronic experiment on three awake macaca cynomolgus, the activity of 27 neurons localized in the corpus luysi was recorded. their spontaneous activity is continuous without rhythmicity or bursts. all neurons responded to a stimulation of the striatum by an initial activation followed by an inhibition. these facts reveal the occurrence of a double projection from the putamen and also from the head of the caudate nucleus to the corpus luysi.	1975	811384
[characterization of mycoplasms isolated from imported nonhuman primates (author's transl)].	mycoplasms were isolated from 35 (16%) of 215 specimens collected from 20 crab-eating monkeys (macaca irus), 9 green monkeys (cercopithecus aethiops) and from 9 common squirrel monkeys (saimiri sciurea). all these animals had been imported from south-east asia, africa and south america being apparently healthy. a total of 38 large and 20 small colony-mycoplasma strains were isolated from the nasal and oral cavity, urethra, vagina and rectal feces. the large colony-mycoplasmas could be differenti ...	1975	811474
resistance to psychopathology in adolescent monkeys (macaca fascicularis) reared with mothers and peers.		1975	811699
clinical note--a case of bilateral dental fistula in a cynamolgus monkey (macaca fascicularis).		1975	811928
phenylalanine hydroxylase of macaca irus a simple purification by affinity chromatography.		1975	812698
ocular effects of clonidine in cats and monkeys (macaca irus).		1975	812714
schistosoma japonicum: immunopathology of nephritis in macaca fascicularis.		1975	812719
atherosclerosis in rhesus and cynomolgus monkeys.		1976	813206
distribution of an 125i-labelled chloroquine analogue in a pregnant macaca monkey.	whole body autoradiography of a pregnant monkey (macaca irus) of late gestation was performed 72 h after an intravenous injection of the 125i-labelled chloroquine analogue 4-(3-dimethylaminopropylamino)-7-iodoquinoline (dapq). the overall distribution pattern in the monkey was similar to that which was earlier observed in rodents. a few species differences, however, were found in the monkey as compared to the rodents: a high accumulation in the inner part of the adrenal cortex, a high level in t ...	1975	813334
[artificial nursing of new-born cynomolgus monkeys as a model of the human infant and development of abnormal behavior (author's transl)].	new-born cynomolgus monkeys were sucessfully reared by artificial nursing that was started just afterbirth with a 12% solution of a commercially prepared powdered-milk (yukijirushi, p 7a) containing 13.3g of protein per 100g. marked growth-retardation was observed in baby cynomolgus monkeys fed on a 12% solution of the modified p 7a milk containing only 6.6g of protein per 100g to which lactose was supplemented to give a baby monkey the same caloric value as that of the original p 7a milk. these ...	1975	814006
[the weight of the reproductive organs, hypophysis and thyroid of male cynomolgus monkeys. (macaca fascicularis) (author's transl)].	the present short paper deals with the weight of the male reproductive organs of wild-imported cynomolgus monkeys, including the testes, epididymides, ductus deferens, vesicula seminalis prostata, bulbo urethralis and penis. in addition, the size of the testes and the weight of the thyroid and hypophysis are also presented.	1975	814007
failure of carbon monoxide to induce myocardial infarction in cholesterol-fed cynomolgus monkeys (macaca fascicularis).	twenty-six adult female cynomolgus monkeys (macaca fascicularis) were randomly assigned to four groups which were fed on a standard laboratory diet or a semipurified diet containing cholesterol. in two of the groups, the monkeys were exposed intermittently to co throughout the day for 14 months; the control animals breathed room air. no myocardial infarctions were observed, and the ecg showed a transitory injury current in only one animal. no differences in plasma cholesterol levels or in aortic ...	1976	815001
experimental dirofilariasis in macaques. iii. susceptibility and host responses to dirofilaria tenuis of raccoons.	in this third of a series of studies on experimental dirofilariasis in primate hosts, 3 macaca cynomolgus, 6 m. speciosa, and 2 m. mulatta were inoculated with infective larvae of dirofilaria tenuis, a parasite of the raccoon, and were killed at periods ranging from 2 weeks to 13 months of infection. one m. mulatta and one m. speciosa were treated daily with prednisolone beginning 2 months after inoculation; worms were recovered from these and 5 other monkeys (7 of 11). microfilaremia was detect ...	1976	816216
thalamic projections from the precentral motor cortex in macaca fascicularis.	radioactive amino acids were injected into area 4 in 7 monkeys (macaca fascicularis). ipsilateral corticothalamic projections were traced to olszewski's nucleus ventralis lateralis pars oralis and pars medialis, the nucleus ventralis posterior lateralis pars oralis, the nucleus ventralis posterior medialis and inferior and to the nucleus reticularis. some fibers appeared to terminate in the ipsilateral nucleus ventralis lateralis pars caudalis, the nucleus lateralis posterior and the nucleus sub ...	1976	816421
immunization of macaca fascicularis (macaca irus) monkeys with streptococcus mutans: specificity of antibody responses in saliva.	m fascicularis monkeys were immunized subcutaneously in the vicinity of the major salivary glands and by retrograde infusion into the parotid duct, with a vaccine containing formalin-killed s mutans strain 6715 cells and culture-fluid antigens. indirect immunofluorescent staining was used to titrate and classify antibodies. subcutaneous immunization induced only a serum response, whereas intraductal infusion stimulated both an iga antibody response in the parotid fluid and a serum response. immu ...	1976	816835
aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta.	the interrelationships between hypertension and atherosclerosis were investigated in a subhuman primate model (cynomolgus monkey) with hypertension produced by surgically coarcting the miathoracic aorta. the hypertensive coarcted monkey fed a low cholesterol diet for 6 months did not develop complicating atherosclerosis but did develop focal intimal lesions as well as marked thickening of the musculoelastic media of both the large and small arteries. fibrocellular thickening of the intima and me ...	1976	817849
immunoglobulins a, g, and m in serum and in some secretions of monkeys (macaca fascicularis syn. irus).	the purpose of this investigation was to study the distribution and levels of the following immunoglobulins, iga, igg, and igm ,in sera and in some secretions of monkeys (m. fascicularis). igg, iga, and igm were isolated from monkey serum and secretory iga was separated from monkey milk by combined gel filtration and ion-exchange chromatography. these pure preparations served as standards to quantitate immunoglobulins in sera and secretions by single radial immunodiffusion. antisera were raised ...	1976	818024
proliferative epithelial lesions of the urinary bladder in cynomolgus monkeys (macaca fascicularis) infected with schistosoma intercalatum.	five cynomolgus monkeys (macaca fascicularis) were infected with schistosoma intercalatum, a helminth that is morphologically similar to schistosoma haematobium. infections were readily established and remained active until the monkeys were sacrificed 21 to 84 weeks after exposure. although the schistosomes were located predominantly in mesenteric and hepatic portal venules, schistosome eggs were found in the bladders of 3 monkeys. nodules of atypical epithelial cells interpreted as superficiall ...	1976	819136
the effect of entrapment in liposomes on the in vivo distribution of [3h]methotrexate in a primate.	entrapment of methotrexate (mtx) plus [3',5', 9(n)-3h]methotrexate into positively charged liposomes greatly alters the subsequent distribution of [3h]mtx in a cynomologous monkey (macaca irus) after a single i.v. injection ([3h]mtx; refers to total radioactivity derived from purified [3h]mtx). when [3h]mtx is incorporated into small, sonically disrupted liposomes, the level of the entrapped [3h]mtx in the total plasma volume was still 50% of the total injected dose after 4 hr, which is 100 time ...	1976	819137
residual pilocarpine effects on outflow facility after ciliary muscle disinsertion in the synomolgus monkey.	outflow facility responses to pilocarpine were determined in ten cynomolgus monkey eyes after disinsertion of the ciliary muscle from the scleral spur. the effect of large intravenous dose given on one occasion was compared to the effect of intense topical treatment for 18 to 24 hours on another occasion. the effect of the two modes of treatment differed from eye to eye, but were similar in the individual eye. in some eyes facility rose while in others it fell. the average effect of both treatme ...	1976	819392
evaluation and re-evaluation of genetic radiation hazards in man. ii. the arm number hypothesis and the induction of reciprocal translocations in man.	the arm number hypothesis proposed by brewen and collagues in 1973 has been examined in the light of information thus far available from mammalian studies. in experiments with peripheral blood lymphocytes (radiation in vitro), a linear relationship between dicentric yield and the effective chromosome arm number of the species was obtained in the mouse, chinese hamster, goat, sheep, pig, wallaby and man. however, the data are not consistent with such a relationship in several primate species (ma ...	1976	819823
responses of subthalamic and pallidal neurons to striatal stimulation: an extracellular study on awake monkeys.	the unitary activity of subthalamic neurons (corpus luysii) and of gp neurons was recorded extracellularly on awake monkeys (macaca cynomolgus). striatal stimulation induces in subthalamic (sth) neurons a short latency spike discharge (10-15 msec) followed by a long lasting depression of the spontaneous activity. as, according to anatomical studies, the subthalamic nucleus is principally connected to the globus pallidus (gp), electrophysiological relations between striatal and gp neurons and bet ...	1976	820409
[nursing procedures for cynomolgus monkey infants (author's transl)].	this paper describes the results of the artificial nursing of 8 infant cynomolgus monkeys (macaca fascicularis) weighing 230-350 g at birth. the infants were separated from their mothers just after or 2 days after birth and were kept in a specially deviced small cage (photo 1 & 2). they were fed on 6.4-16.6% solution of a commercially available powdered milk for the human baby. apple juice also was given to them from the 3rd or 4th week on. in about the 6th week, the infants received solid foods ...	1976	820560
[surface structure of the lips and tactile hairs of cynomolgus monkeys. scanning electron microscopic studies on the transitional part between the skin and mucosa 1].		1976	821303
applanation tonometry in the conscious cynomolgus monkey (macaca fascicularis).	four monkeys (macaca fascicularis) were trained to tolerate applanation tonometry while fully conscious. the tonometer used was the draeger tonometer with an applanation area of 3.06 diameter, but with a reduced application surface (4 mm instead of 6.8 mm diameter). the reduction did not change the calibration and is applicable in this monkey species without any correction factor. the mean intraocular pressure determined was 19.12 mmhg.	1976	821306
effect of bran and cholestyramine on plasma lipids in monkeys.	semipurified diets whose cholesterol content varied from 34 to 120 mg/100 kcal were given to adult female cynomolgus monkeys (macaca fascicularis) for 9 months. the intake of dietary fiber was increased through the addition of wheat, rice, or soya bran; 5% cholestyramine was given to one group of monkeys. none of the brans reduced plasma levels of cholesterol, whereas cholestyramine produced marked hypocholesterolemic effects. triglyceride levels increased with higher cholesterol intake, but no ...	1976	821335
proline-rich proteins in membranes and contents of monkey (macaca irus and cercopithecus aethiops) parotid zymogen granules.		1976	821460
metabolism of 16,16-dimethyl-prostaglandin f2alpha in the cynomolgus monkey and the human female.		1976	821483
identification, classification and anatomical segregation of cells with x-like and y-like properties in the lateral geniculate nucleus of old-world primates.	1. all the cells (158) that we studied in the lateral geniculate nuclei of macaca nemestrina and macaca irus could be distinguished as either x-like or y-like on the basis of their responses to tests developed to classify cat retinal and lateral geniculate nucleus cells. these tests include responses to stationary spots, fast moving wands and moving gratings. 2. response latencies to electrical stimulation of the optic chiasm were determined for 130 cells; no x-like cell showed a latency shorter ...	1976	822151
disynaptic inhibition of spinal motoneurones from the motor cortex in the monkey.	1. the neuronal mechanism of disynaptic inhibition of spinal motoneurones by the corticospinal tract was investigated in macaca irus. surface stimulation or weak intracortical stimulation was used in order to evoke the inhibition. intracellular records were taken from motoneurones in lumbar segments. 2. both the disynaptic i.p.s.p.s evoked from group ia afferents and the disynaptic i.p.s.p.s evoked from corticospinal fibres were found to be depressed by conditioning stimulation of motor axons to ...	1976	822152
histochemical and biochemical properties of the labial and palatine glands and their secretions in the macaca irus and cercopithecus aethiops monkeys.	the increasing use of non-human primates in experimental studies in dentistry demands detailed knowledge of their basic oral biology. the labial and palatine glands and their secretory products were compared in two commonly used monkey species. the mucous cells of both gland types appeared to elaborate sulphated muco-substances and the serous demilunes of the labial glands neutral mucosubstances. the secretions of these glands, as obtained by in vitro cultivation of glandular tissue were subject ...	1976	822685
influence of cataleptoid anaesthetic agents on the intraocular pressure in monkeys (macaca fascicularis).	trained monkeys which allowed a tonometry while conscious were used to test the influence of cataleptoid anaesthetics on intraocular pressure (iop). the drugs were injected intramuscularly in two dosages: with the lower dose (dt) it became just possible to perform a tonometry in untrained monkeys. the second dose (ds) induced surgical anaesthesia. the drugs used were: phencyclidine, dt: 0.6-0.7 mg/kg, ds: 1.2-1.4 mg/kg. ketamine, dt: 4-6 mg/kg, ds: 25 mg/kg. ci-744, a combination of a pure catal ...	1976	822686
effect of malnutrition on cortisol-binding protein in the lens of cynomolgus monkeys.	a cortisol-binding protein exists in the lens of cynomolgus monkeys as in other species. the cortisol-binding capacity decreased markedly with a diet either moderately or severely depleted of protein, even if the diet was later changed to a normal diet during infancy. this suggests that malnutrition may cause insufficient synthesis of the important factors controlling the inactivation of steroid hormone in the lens.	1976	823312
caesarean section in the java monkey (macaca irus)--a case report.		1976	823378
histochemical studies on beta-glucuronidase activity in developing teeth and bone of rat and macaque monkey.	the enzyme beta-glucuronidase (e.c. 3.2.1.31.) has been studied in developing teeth and bone of sprague-dawley rats and macaque monkeys (macaca irus) by means of histochemistry using naphthol-as-bi-beta-d-glucuronide as substrate and hexazotized pararosanilin as coupling reagent. since beta-glucuronidase is sensitive to fixatives a freeze-sectioning technique has been used which made it possible to section highly mineralized tissues without previous fixation and decalcification. in the bone enzy ...	1975	823790
loss of acute pilocarpine effect on outflow facility following surgical disinsertion and retrodisplacement of the ciliary muscle from the scleral spur in the cynomolgus monkey.	an ab-interno goniotomy-like operation for disinserting the ciliary muscle from the scleral spur in cynomolgus monkeys is described. following postoperative miotic and corticosteroid treatment, the eyes did well clinically and the muscle reattached to the sclera posterior to the spur. outflow facility and intraocular pressure were mildly reduced. there was drainage of aqueous humor via the conventional outflow routes, and blood flow to the ciliary body. the outflow facility increasing effect of ...	1976	824222
effects of paracentesis on the blood-aqueous barrier: a light and electron microscopic study on cynomolgus monkey.	the effects of paracentesis on the blood-aqueous barrier of cynomolgus monekeys were studied by light and electron microscopy. the following regions of the eye were examined: ciliary body, iris, schlemm's canal, juxtacanalicular connective tissue, and trabecular meshwork. prominent structural alterations were seen in the ciliary epithelium at the anterior portion of the pars plicata, but the epithelium at the posterior portion of the pars plicata and at the pars plana appeared less disrupted. pl ...	1976	824223
priming of macaca cynomolgus philippinensis with purified antigen of brucella melitensis before injection of rev. i vaccine.	in experiments designed for study of bacteremia and serologic response of macaca cynomolgus philippinensis to vaccination with a soluble antigen (fraction i) of brucella melitensis and the live rev. i vaccine strain, fraction i and rev. i were administered both four weeks apart and simultaneously. one of three monkeys given the vaccines four weeks apart and two of three monkeys vaccinated with fraction i and rev. i in a single injection developed transient bacteremia, as shown by blood cultures. ...	1976	824373
oral glucose tolerance test in the cynomolgus monkey (macaca fascicularis).	the glucose tolerance test was simplified so that it could be performed on more than one cynomolgus monkey (macaca fascicularis) at a time. glucose was administered orally in a dose of 2 g/kg body weight as a 50% aqueous solution, and blood samples were taken just before and 30 minutes and 150 minutes after glucose administration. the simplified test was conducted on a total of 93 cynomolgus monkeys. glucose tolerance curves obtained by this method were classified into three patterns with regard ...	1976	824499
initial colonization of teeth in monkeys as related to diet.	the initial phases of plaque development on nonretentive tooth surfaces were studied bacteriologically in macaca irus monkeys fed by stomach tube and provided with various oral supplements. except for the oral implantation of streptococcus mutans in some of the animals, the oral flora was not changed prior to the studies. dental plaque was allowed to develop on initially cleaned tooth surfaces for 3 to 5 h. plaque samples were collected and cultured on a number of selective and nonselective agar ...	1976	825462
an outbreak of epistaxis in cynomolgus monkeys (macaca fascicularis).		1976	826008