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chlorpromazine inhibition of dehydration-induced histological changes in the hypothalamic neurosecretory system of the musk shrew, suncus murinus l. 19715172180
a serological survey of rodent plague in taiwan and offshore islands.serological surveys were made on individual sera of small animals trapped on taiwan and offshore islands. the animals were shrews of the species suncus murinus, and rats of the species rattus rattus and r. norvegicus. the tests showed that on makung in the peng-hu islands (pescadores), 66% of the shrews, 30% of the r. rattus and 15% of the r. norvegicus had passive haemagglutination titres with fraction 1 antigens in the range of 1:16 to 1:256, indicative of previous plague infections. these obs ...19685303332
post-parturitional conception in captive musk shrews, suncus murinus. 19705492030
dna synthesis in duplicate-type sex chromosomes of the indian house shrew, suncus murinus (insectivora). 19705501395
sustained fertility after cdcl 2 injection by a non-scrotal mammal, suncus murinus (insectivora, soricidae). 19705521473
inhibition by reserpine of histological changes induced by hypertonic saline in the hypothalamic neurosecretory system of the musk shrew, suncus murinus l. 19715564415
preliminary studies on experimental transmission of kyasanur forest disease virus by nymphs of ixodes petauristae warburton, 1933, infected as larvae on suncus murinus and rattus blanfordi. 19685679151
free amino acids in the testes of meriones hurrianae jerdon and suncus murinus sindensis anderson. 19685718540
[a new parasite, gongylonema bigueti n. sp., parasite of the shrewmouse, suncus murinus (l.) of south vietnam]. 19685756593
seasonal changes in weight and reproductive activity of suncus murinus in west bengal, india. 19665905563
[life cycle of seuratum nguyenvanaii, le-van-hoa, 1964, parasite of the shrew-mouse, suncus murinus (l.) in vietnam. (preliminary note)]. 19666012572
ecology of plague in vietnam. i. role of suncus murinus. 19676024813
hemagglutination-inhibiting antibody in hemorrhagic fever with renal syndrome.hemagglutination activity was demonstrated in a hantaan virus antigen prepared from infected suckling mouse brain by sucrose-acetone extraction. hemagglutination of goose erythrocytes was ph dependent and was optimal at ph 6.0-6.2. immunofluorescent and hemagglutination-inhibiting antibodies were significantly correlated in 80 human and 13 animal sera. hemagglutination-inhibiting antibody was present in some patients 20 years after the onset of hemorrhagic fever with renal syndrome. the hemagglu ...19846150063
effect of n,n'-bis(dichloroacetyl)-i,8-octamethylenediamine (win 18446) on the testis + epididymis of the musk shrew suncus murinus l. 19806260633
the reaction of funambulus tristriatus tristriatus rattus blanfordi and suncus murinus to kyasanur forest disease virus. 19816273309
susceptibility of cynopterus sphinx (frugivorus bat) & suncus murinus (house shrew) to japanese encephalitis virus. 19846327512
comparative cytoarchitectonic study of gudden's tegmental nuclei in some mammals.the structure and location of the dorsal and ventral tegmental nuclei of gudden were studied in brains of 12 species of mammals. the ventral tegmental nucleus of gudden is composed of oval or polygonal, medium-sized, well-stained cells, and includes the pars principalis situated ventral to the fasciculus longitudinalis medialis, and the pars suprafascicularis in the central gray matter dorsal to the fasciculus longitudinalis medialis (in the golden hamster, mouse, vole, and house shrew). the dor ...19836345599
[experimental animal information file: muskrats (suncus murinus)]. 19836349547
[experimental animal information file: chromosomes of muskrats (suncus murinus)]. 19846375576
dose-survival time response of suncus murinus from whole-body irradiation. 19846392540
comparative anatomical study of the tegmentomammillary projections in some mammals: a horseradish peroxidase study.mammillary projections from each subnuclei of gudden 's tegmental nuclei were investigated by retrograde transport of horseradish peroxidase (hrp) in the cat, rat, guinea pig, golden hamster and house shrew (suncus murinus, insectivora). the dorsal tegmental nucleus of gudden (td) is composed of the pars dorsalis (tdd) and the pars ventralis ( tdv ) in the cat, rat, guinea pig, and golden hamster, but the td of the house shrew can not be divided. the ventral tegmental nucleus of gudden (tv) is c ...19846428701
genetic variants found in plasma alpha-amylase and erythrocyte carbonic anhydrase in the musk shrew (suncus murinus).genetic variants of plasma alpha-amylase and erythrocyte carbonic anhydrase in the musk shrew (suncus murinus) were found by electrophoreses using cellulose acetate plates. it was demonstrated that phenotypic differences of alpha-amylase are controlled by two codominant alleles (amy-1a and amy-1b) at a single autosomal locus (amy-1). the segregation data of the carbonic anhydrase phenotypes in the progeny supported the genetic theory of two codominant alleles (car-1a and car-1b) at a single auto ...19846432562
mesostigmatid mites associated with the house shrew, suncus murinus, in rangoon, burma.in rangoon and vicinity suncus murinus comprises almost 20% of the small mammal population with almost equal load of mesostigmatid mites compared to murine rodents. suncus murinus was infected by four species of laelapids, out of which l. myonyssognathus seems to infest more on urban s. murinus. the infestation of the free living androlaelaps or hypoaspis species is higher on the rural shrews while the cheyletus species is higher on the urban than the rural s. murinus.19806452696
[growth and sexual maturation of the male house musk shrew (suncus murinus)].the sexual maturation in the male house musk shrew, suncus murinus, was investigated by weighing gonads, accessory sexual organs and various other organs, and measuring testosterone concentrations in the plasma from birth to 50 days of age. the histological and histochemical studies of the testis were also carried out. testicular weight increased markedly from 10 days of age. on 15 days of age, the activity of delta 5-3 beta-hydroxysteroid dehydrogenase (hsd) was detected in leydig cells. in acc ...19846468514
[planned reproduction of the house musk shrew (suncus murinus)].to investigate methods for the planned reproduction of the house musk shrew (suncus murinus), increased reproduction was attempted from may through august, 1980 using 13 females and 13 males obtained from the breeding colony in the laboratory of animal genetics, faculty of agriculture, nagoya university. as a result, a reproduction colony consisting of 128 females and 60 males was formed in september, 1981. this was followed by repeated selective culling until a planned reproduction system with ...19846468518
the median and lateral substantia gelatinosa in the cervical cord of the musk shrew (suncus murinus) and its synaptic composition.the extent and laminar arrangement of the substantia gelatinosa (sg) were examined in the cervical spinal cord of the shrew. between c1 and c6 or c7 the three dorsal layers on either side of the gray matter were confluent at the commissura posterior grisea in shrews of both sexes. lamina i was thin with no large marginal cells. lamina ii comprised the major part of the sg, consisting of outer cellular and inner neuropil layers. lamina iii was composed of a meshwork of axon terminals, dendritic p ...19846476406
serial transplantation to nude mice of an androgen-dependent pilosebaceous tumor developed in suncus murinus.the pilosebaceous tumor spontaneously developed on the sidegland of an old male suncus murinus was serially transplanted into male nude athymic (balb/c-nu/nu) mice. by the 18th generation, tumor growth occurred in about 70% of them. the transplantability of the tumor maintained in these male mice to female or castrated male nude mice was less than 35%. the histological features of the tumor did not differ by the hormonal status of hosts. tumor growth started later and was slower in females than ...19846498827
tick-borne rickettsioses in pune district, maharashtra, india.an extensive study on tick-borne rickettsioses in the pune district of maharashtra revealed that indian tick typhus exists as a zoonosis, which only occasionally causes disease in man. by sero-conversion in guinea pigs, presumptive isolates of rickettsia conori and coxiella burnetii were recovered from 4 of the 11 species of ticks examined. boophilus microplus and rhipicephalus haemaphysalis were found to be harbouring r. conori whereas c. burnetii was isolated from haemaphysalis intermedia and ...19846500861
laryngeal cartilages in the house musk shrew (suncus murinus). 19846507028
role of progesterone on the control of scent marking in suncus murinus viridescens (blyth).the effect of castration and administration of progesterone in different doses on the specialized integumentary glands and scent marking behavior in male musk shrew, suncus murinus viridescens were studied. castration effected a considerable atrophy of the secretory epithelial tissues of the flank, oral lip and perineal glands with marked regression in their secretory output. further, the scent marking frequencies were also reduced and attained a minimum level by the end of 4 weeks after castrat ...19846514831
fecal pellets from a commensal shrew (suncus murinus) and a house gecko (gekkonidae).examination of excreta pellets from commensal shrew (suncus murinus) and tropical house geckos (gekkonidae) showed several characteristics that were useful in distinguishing these pellets from those of commensal rodents. commensal shrew pellets contained a large number of embedded insect fragments but no embedded hairs. each shrew pellet was associated with a distinctive circular stain on the floor or container surface where it was found. gecko pellets were composed entirely of tightly packed in ...20136520076
the occurrence of salmonellae in house shrews and rats in ipoh, malaysia.house shrews (suncus murinus) and rats (rattus rattus diardii), trapped during a survey period from july 1978 to december 1979 and thereafter on a random basis, from residences within and outside the veterinary research institute, ipoh, malaysia campus, were bacteriologically examined for the presence of salmonellae. of the 55 shrews and 8 rats examined, 39 (71%) shrews and 2 (25%) rats were found positive. there were 46 salmonella isolates which included 5 dual infections. these were serotyped ...19846523172
fine structure of the lutein cell in the house musk shrew, suncus murinus.the ultrastructure of lutein cells during pregnancy and the post partum period was examined by transmission electron microscopy in the house musk shrew, suncus murinus. lutein cells on day 13 of pregnancy contained an extensive system of anastomosing tubules or cisternae of smooth er and many enlarged mitochondria with numerous tubulovesicular cristae. from day 13 on, the number of small granules, possibly lysosomes, increased gradually. between day 20 and 25, the loss of smooth er began and elo ...19846525615
effect of flutamide on the testis and accessory sex glands of the musk shrew, suncus murinus l.administration (100 mg/kg body weight/day, for 14 and 21 days) of flutamide induced duration-dependent regressive changes in the male reproductive organs. the seminiferous tubules in drug-treated shrews exhibited marked regressive changes with suppression of spermatogenesis; the tubules were devoid of spermatozoa and contained sertoli cells and spermatogonia. however, there was no change in testicular weight, leydig cell appearance and the concentrations of testicular protein, rna and dna in dru ...19846541143
genetic polymorphism of the vitamin d binding protein (gc) in the musk shrew (suncus murinus).in the musk shrew (suncus murinus), the electrophoretic bands in the post-albumin region were identified as vitamin d binding protein (gc) by the [3h] vitamin d3 binding method. three gc phenotypes were distinguished from each other: a single faster band (gc-a), a single slower band (gc-b) and the double bands (gc-ab). results of mating experiments indicated that the gc-a and gc-b are controlled by two codominant alleles, gca and gcb at an autosomal locus (gc), respectively. it was noticed that, ...19846547578
[electron microscopy studies on the myoepithelial cells of the submandibular gland of the musk shrew, suncus murinus]. 19836587251
an androgen-dependent pilosebaceous tumor spontaneously developed in the japanese house musk shrew suncus murinus.following administration of [3h]testosterone to castrated male japanese house musk shrews (suncus murinus), radioactive metabolites were detected in sidegland nuclei and the major one of them was dihydrotestosterone (dht). the androgen binding capacity of the cytoplasmic fraction of sideglands was measured in vitro by the use of [3h]r1881 as a ligand. the binding showed a high affinity for r1881 (kd = 6.2 x 10(-10) m) and a low capacity (bmax = 22 fmol/mg protein). sucrose density gradient centr ...19836604195
some observations on the structure of suncus liver with special reference to the vitamin a-storing cell.the structure of the liver of the thick-tailed shrew (suncus murinus) was studied with special reference to the vitamin a-storing cell. the macroscopic arrangement of hepatic lobes was the same as those of rodents. connective tissues of glisson's sheath were not prominent. there were gradual differences in the size and the cytoplasmic contents of hepatocytes among perihepatic, intermediate, and periportal regions. these correspond to the acinar zones 3, 2, and 1 of rappaport, respectively. the u ...19836613904
effect of clomiphene citrate on the testis, epididymis and accessory sex glands of the musk shrew (suncus murinus l.).the effects of oral administration of clomiphene citrate (50 mg/kg body weight) on the testis, epididymis and accessory sex glands of the musk shrew were investigated. the drug induced duration-dependent alterations in the weight and histology of these organs. the drug produced significant reduction in testicular weight with severe degenerative changes in seminiferous tubules; leydig cells were also atrophied. however, no significant change was found in the levels of protein, rna and dna in the ...20166614857
mammary growth and plasma progesterone level during pregnancy in the house musk shrew, suncus murinus linnaeus.the process of growth of the mammary gland and change in the plasma concentration of progesterone were investigated throughout the course of pregnancy (30 days) in the home musk shrew, suncus murinus l. development of the mammary gland of the musk shrew was limited during the first half of pregnancy. extensive branching of ducts and conspicuous alveolar formation and a marked increase in the dna content of the gland started between day 15 and 20 of pregnancy, and continued until term. milk synth ...19836671463
changes in the renal morphology after calcitonin treatment in the house shrew, suncus murinus. 20066677197
cream, a new coat-color mutant in the musk shrew.a coat-color mutant was found in the wild musk shrew (suncus murinus, insectivora). five musk shrews with gray pelage, the common coat color of this species, were captured in the village of tambum near jakarta, indonesia. two males and two females were transported to japan and mated. matings between one male and two females segregated several cream-colored offspring, a color that had never been seen before in this species. from the pedigree record and data on mating experiments, it was confirmed ...20036715865
behavior of sex chromosomes during meiosis in the house shrew.the behavior of the sex chromosomes during meiosis in the house shrew, suncus murinus, shows some interesting features. both x- and y-chromosomes are large and biarmed and have huge segments of c-band material in noncentromeric areas. a distinct chiasma is formed between the short arms of the x and y chromosomes and the heterochromatic regions in the bivalents show desynapsis in the form of a bulge.20036715866
osteology of the musk shrew (suncus murinus).in the present study using 29 adult musk shrew of both sexes, most findings were identified to be similar to those by sharma (1958) on the osteology , and there was no remarkable difference between skeletal structure of wild musk shrew in india and that of breeding species in japan except the number of the vertebra lumbalis and existance of the dens caninus . however, it was elucidated that the os articulare coccygis like h-letter in shape is characteristic for this animal, and shows 17 componen ...19846721174
cytochrome p-450-dependent fatty acid hydroxylase system in japanese house musk shrew, suncus murinus.the substrate specificity and other properties of a fatty acid hydroxylase system in liver microsomes of the japanese house musk shrew, suncus murinus, were examined. shrew liver microsomes catalyzed the hydroxylation of various saturated fatty acids (c8-c18) to the corresponding omega- and (omega-1)-hydroxy derivatives. the relative activities of the hydroxylase with these substrates were as follows: c12 (100, actual conversion: 7.05 nmol/mg of microsomal protein/min), c10 (90), c14 (87), c16 ( ...19846725235
acidic glycolipids from kidney of suncus (insectivora).lipids were extracted from the kidney of house musk shrew (suncus murinus), which belongs to the order insectivora. acidic glycosphingolipids were purified from lipid extracts by mild alkaline methanolysis followed by column chromatographies on deae-sephadex and silica beads (iatrobeads). purified glycolipids were analyzed by thin-layer chromatography, mild acid hydrolysis, gas liquid chromatography of the methyl glycosides after methanolysis and gas chromatography-mass spectrometry of the parti ...19846746617
[length and weight of gastrointestinal tracts of pikas, suncus, millardias, mice and rats].the length and weight of gastrointestinal tracts including contents of ten week old male pikas (ochotona rufescens rufescens) and suncus (suncus murinus) were measured and they were investigated and compared with those of millardias, icr-mice and wistar-rats. the length from the duodenum to the anus of pikas was much longer and the weight from the stomach to the anus was about 16g per 100g of body weight. the weight of cecum was about 7g per body weight and they were heavier than those of other ...19836852120
[suncus (suncus murinus) and cancer research]. 19817032955
light and electron microscopic observations of the spleen in the musk shrew, suncus murinus.in the spleen of the musk shrew, a marginal zone was clearly demonstrable between the white pulp and the red pulp. the white pulp was separated from the marginal zone by a septum, a circumferential layer of reticular cells and fibres, and between the marginal zone and red pulp there was a population difference of blood cells. the white pulp consisted of periarterial lymphatic sheaths and lymphoid follicles including germinal centres. the marginal zone was filled by numerous erythrocytes, some ly ...19827076539
population indices of chiggers (leptotrombidium deliense) and incidence of scrub typhus in chinese military personnel, pescadores islands of taiwan, 1976-77.larval leptotrombidium deliense were recovered from live-trapped suncus murinus, rattus rattus and r. norvegicus captured in the pescadores islands of taiwan during 1976 and 1977. weekly and monthly indices of chigger infestation expressed as a percentage of hosts infested and the number of chiggers per host for s. murinus and rattus spp. were calculated. close correlations were observed between monthly indices of l. deliense measured for s. murinus and rattus spp. and the number of laboratory-c ...19827080163
nuclear uptake of radioactivity by cells of pituitary, brain, uterus, and vagina of the asian musk shrew (suncus murinus) following [3h] estradiol administration. 19827084657
taste preferences for amino acids in the house musk shrew, suncus murinus.taste preferences in house musk shrews for amino acids as well as nacl, sucrose, quinine hydrochloride, hcl and saccharin na were studied by employing the two-bottle preference technique. shrews showed a preference for 0.2--05. m sucrose but a moderate rejection to nacl and a strong rejection to quinine, hcl and saccharin. they exhibited a marked preference for many naturally occurring l-alpha-amino acids with aliphatic side chains at both 0.02 and 0.2 m. increase in the aliphatic side chain len ...19827100283
spontaneous development of pilosebaceous tumors in the japanese house musk shrew (suncus murinus).cutaneous pilosebaceous tumors developed spontaneously in high incidence in a colony of the japanese house musk shrew (suncus murinus) that has been adapted to laboratory breeding. multiple tumors of this sort developed in the scalp, back, and hip of older animals, with a marked preponderance in males. the co-presence of tumors with a wide variety of histological grading from benign to malignant in a host or in a single tumor mass was a unique feature.19827117740
induction of ovulation in the musk shrew suncus murinus l. by hcg administration. 19827118189
effect of glucagon administration on kidney morphology in house shrew, suncus murinus. 19827145317
effect of calcitonin on calcitonin cells, parathyroid glands and serum electrolytes in the house shrew (suncus murinus).porcine calcitonin (ct) (0.5 mrc unit daily) was administered intraperitoneally to house shrews, suncus murinus, for 42 days. the changes in serum calcium and phosphate levels as well as the light microscopical alterations of the parathyroid and calcitonin cells (c cells) between the 1st and 42nd day of treatment were recorded. the serum calcium level shows a fall up to the 7th day of treatment and thereafter it increases to normal values. the hypophosphataemic effect of ct increases progressive ...19827148381
morphology and distribution of calcitonin cells in the house shrew, suncus murinus.the thyroparathyroid complex of house shrews was cut into serial sections. for demonstration of calcitonin cells (c cells) the sections were stained by he, pas/haematoxylin, heidenhain's iron haematoxylin, mallory's aniline blue, toluidine blue, davenport's silver impregnation and lead haematoxylin. the c cells are oval to slender in shape and are distributed unevenly (totally lacking from the peripheral, cranial, caudal and isthmus region). they are also encountered in the internal parathyroid ...19827168575
morphological studies on the nasal turbinates of the musk shrew (suncus murinus riukiuanus). 19807218621
failure of 5-thio-d-glucose to induce antispermatogenic effects in the musk shrew, suncus murinus l. 19817236825
effect of vasectomy on the testis and accessory sex glands of the musk shrew, suncus murinus l.the effects of uni- and bilateral vasectomy on the testis and accessory sex glands were studied at intervals up to six months. vasectomy induced degenerative changes in the seminiferous tubules during the first four months after the operation; thereafter a partial recovery of spermatogenesis was noticed at six months post-vasectomy. unilateral vasectomy induced degenerative changes only in the ipsilateral testis; the contralateral testis presented normal histology and showed no evidence of compe ...19817262038
response of calcitonin cells, parathyroid, serum calcium and serum inorganic phosphorus during glucagon-induced hypocalcemia in the house shrew, suncus murinus. 19817296607
the primary structure of adult hemoglobin of musk shrew (suncus murinus).an alpha chain and two beta chains beta i and beta ii) were obtained from adult hemoglobin of the musk shrew (suncus murinus) by cm-cellulose column chromatography. the s-carboxymethylated alpha chain and the s-aminoethylated beta chains were each digested with trypsin and the amino acid sequences of the tryptic peptides obtained were established. the ordering of these peptides in the alpha and beta chains was deduced from their homology with the primary structures of the alpha and beta chains o ...19817309005
effect of vasectomy on the epididymis of a non-scrotal mammal suncus murinus l. 19817309137
morphological study on the intestine of the must shrew, suncus murinus. 19807366055
[electrophysiological and electronmicroscopical study of the retina of suncus murinus (author's transl)]. 19807377033
ovulation, ovum maturation and changes in plasma and adrenal progesterone concentrations in the musk shrew (suncus murinus). 19807378540
a study of small mammals in the ciloto field station area, west java, indonesia, with special reference to vectors of plague and scrub typhus.from june 1977 to june 1978 a study of smal mammals was carried out in the ciloto field station area, west java, indonesia by the who vector biology and control research unit-ii. the objectives of the investigations were to determine the diversity and density of rodent species, to find potential plague and scrub typhus vectors and to study their host-parasite relationships. in the 13 month period a total of 6 species of murids were identified; two species of campestral rats (r. tiomanicus and r. ...19807403957
c-banding pattern on the chromosomes of the japanese house shrew, suncus murinus riukiuanus, and its implication.the c-band on the chromosomes of the japanese house shrew, suncus murinus riukiuanus (insectivora), was studied. various types of c-banding patterns were found in the genome of this subspecies. such banding patterns could be useful for an understanding of autosome and sex-chromosome polymorphisms within s. murinus.19807418836
rodent and scrub typhus survey in a ricefield at kramat tunngak area, tanjung priok, jakarta, indonesia.trapping of small mammals in a ricefield at kramat tunggak around tanjung priok in jakarta city, was carried out from july 1977 through june 1978. of three species of rodents, r.argentiventer was found to be the predominant species in the ricefield. r.r.diardii was an intermittent resident, and the presence of r.norvegicus was interesting observation. s.murinus, a house shrew, was also present. r.argentiventer was the dominant species during the periods when the rice grains were available as a s ...19807434074
a brief note on the morphological and histochemical features of the duodenal glands in 5 species of insectivore.the duodenal glands of the insectivores studied form a narrow, compact glandular collar immediately distal to the pyloric sphincter. the duodenal glands generally empty into overlying intestinal glands however, in 2 species, suncus murinus and talpa europaea, they may empty directly into the intestinal lumen. the glands of all 5 species consist of coiled secretory tubules that show frequent distal branchings. cells of the secretory tubules are pyramidal in shape and show numerous apical secretor ...19807457897
evidence for the lack of hepatic n-acetyltransferase in suncus (suncus murinus).the abilities of liver cytosol fractions from the suncus and sprague-dawley (sd) rats to n-acetylate aniline, p-aminobenzoic acid, p-aminosalicylic acid and 2-aminofluorene (af) were compared. the cytosol from rats n-acetylated these substrates at efficient rates, whereas the cytosol from the suncus did not n-acetylate these substrates at detectable rates. when af was given to the suncus, 2-acetylaminofluorene (aaf), a metabolite of af formed by n-acetyltransferase (nat), was not detectable in s ...19957488230
[histological studies on postnatal development of the musk gland in house musk shrews (suncus murinus)].the development of the musk gland in house musk shrews aged 0 to 21 days was studied lectin histochemically. on about 3 days of age, the musk gland could be discriminated from surrounding skin. this organ developed markedly on days 3 to 7, and its development continued to 21 days of age. histologically, on day 1, the bulges that should develop into musk glands were identified in the vicinity of hair germs. on days 3 to 7, these bulges developed markedly, and on day 21 their structure revealed al ...19957498330
neurofilament expression in lens cells of the house shrew, suncus murinus.immunohistochemical analysis demonstrated that lens cells of the laboratory house shrew, suncus murinus, expressed many intracellular filaments that immunoreacted with pooled monoclonal antibodies against 70-kda, 160-kda, and 210-kda neurofilament triplet proteins. immunopositive filaments in lens cells first appeared in day 13 embryos, while the invaginating lens placode was thickening, and this immunoreactivity was still present in immature lens fiber cells of the adult animal. western blot an ...19947522420
apical cell escape from the neuroepithelium and cell transformation during terminal lip fusion in the house shrew embryo.the house shrew embryo has many cells in the ventricular lumen and on the luminal surface of the fusing terminal lip of the cephalic neural tube. the origin and fate of these cells were studied by means of light and electron microscopy, and by dii labeling in a whole-embryo culture system. the cells appeared at stage 11a and persisted until stage 12a. most of the cells seemed to originate from the neuroepithelium, as shown by frequent observations of epithelial cell escape and dii labeling analy ...19947526743
collagen fibrils in the odontoblast layer in the teeth of the rat and the house shrew, suncus murinus, by scanning electron microscopy using a maceration method.it is not well known whether there are gaps in the tight junctions between odontoblasts and whether the fluid flows from the pulp to the predentin through these gaps. the collagen fibrils in the odontoblast layer were investigated using a maceration method in order to show the existence of the gaps between tight junctions of the odontoblasts. the mandibles containing teeth of the rat and the house shrew were digested by naoh maceration and revealed the architecture of the collagen fibrils under ...19957554943
lymphoid tissue in the kidney of the musk shrew, suncus murinus.we describe a lymphoid tissue in the kidney of the musk shrew, suncus murinus. an anatomically well organised lymphoid tissue, resembling the mucosa-associated lymphoid tissue, is associated with the epithelium of the renal pelvis and the ureter, respectively. lymphoid tissue distributed along the arcuate artery and arcuate vein is not structurally organised in centre and periphery. this tissue type is most prominently developed between blood vessels. immunocytochemistry revealed s-100-immunorea ...19957570577
distribution of lectin binding in the testes of the musk shrew, suncus murinus.distribution of lectin binding in the testis of the musk shrew, suncus murinus, was investigated by light and transmission electron microscopy. not only spermatogenic cells but also sertoli cells bound some lectins. canavalia ensiformis agglutinin (con a) and wheat germ agglutinin (wga, triticum vulgaris), indicating the presence of d-mannose and n-acetyl-d-glucosamine respectively, showed an intense reaction in the acrosomal region of early to late spermatids. ricinus communis agglutinin i (rca ...19957591995
characterization of a novel brain neutral glycosphingolipid composition in house musk shrew (suncus murinus).glycosphingolipids were extracted from the brain of house musk shrew (suncus murinus). neutral glycosphingolipids were purified by qae-sephadex column chromatography followed by high-performance liquid chromatography using an iatrobeads column. purified glycosphingolipids were identified by high-performance thin-layer chromatography, carbohydrate analysis, fast-atom bombardment mass spectrometry and tlc immunostaining. the ganglioside pattern was almost the same as the pattern obtained for rat b ...19957601161
development of the chondrocranial base of the musk shrew, suncus murinus (insectivora).to reveal the developmental process of the chondrocranial base of the musk shrew, suncus murinus (insectivora), light microscopic observation of serial sections and macroscopic observation with whole-mount differential staining of bone and cartilage were performed on day-17 to -22 embryos. the following unusual findings were obtained: (1) the sphenoethmoidal commissure formed a part of the posterior edge of the tectum nasi, implying that the posterior portion of the paries nasi in the mammalian ...19957601229
immunocytochemical identification of serotonergic supraependymal nerve fibers in the third ventricle of the house musk shrew, suncus murinus.supraependymal fibers of the house musk shrew (suncus murinus) were examined by conventional scanning electron microscopy (sem), backscattered electron (bse) imaging of enzyme immunohistochemistry and by immunotransmission electron microscopy in the dorsal part of the third ventricular wall. in this region, ependymal cells were not so heavily ciliated and conventional sem studies showed two main categories of supraependymal fibers. the first type consisted of long fibers fasciculated which were ...19957625602
genetic variation and geographic distribution on the mitochondrial dna in local populations of the musk shrew, suncus murinus.the musk shrew (suncus murinus) is widely distributed throughout asia and east africa. the mitochondrial dna (mtdna) of this species was analyzed in individuals from 31 local populations in nine asian countries and mauritius, using 17 restriction endonucleases. although fourteen and nine mtdna haplotypes were detected from bangladesh and nepal, respectively, one to four haplotypes were found in each southeast asian country, and one common haplotype existed in japan, philippines, vietnam, thailan ...19957632440
spermatogenesis and ultrastructure of a peculiar acrosomal formation in the musk shrew, suncus murinus.spermatogenesis and acrosomal formation in the musk shrew, suncus murinus, were studied by light and transmission electron microscopy. the cycle of the seminiferous epithelium was divided into 13 stages based on the characteristics of acrosomal change and nuclear shape, appearance of meiotic figures, location of spermatids, and period of spermiation. the relative frequencies of stages 1 to 13 were 5.1, 5.9, 10.1, 8.8, 12.5, 11.5, 10.6, 7.9, 6.0, 4.8, 8.9, 3.1 and 4.8, respectively. additionally, ...19947649786
distribution of chicken-ii gonadotropin-releasing hormone in mammalian brain.brains of nonmammalian vertebrates typically contain multiple forms of gonadotropin-releasing hormone (gnrh). until recently, only the mammalian form of gnrh (mgnrh) had been isolated in placental mammals. biochemical and histological data show that both mgnrh and chicken-ii gnrh (cgnrh-ii) are present in a primitive placental mammal, the musk shrew (suncus murinus). similar to the case in nonmammalian species, in the musk shrew, neurons that express cgnrh-ii are located in a discrete cluster in ...19957673483
immunohistochemical characterization of b cells and t cells in musk shrew (suncus murinus) lymphoid tissues using monoclonal antibodies.we have developed and characterized three monoclonal antibodies (mabs), which recognize the surface antigens of musk shrew b cells and t cells. about 30% of all lymph node cells reacted with the mab st1. staining of frozen sections showed that st1-positive cells were located in the primary lymphoid follicles of lymph nodes, and were absent in the thymus. mabs st4 and st2 were also surface-reactive. the st1-negative (about 60% of the total) lymph node cells reacted positively with st4, and about ...19947698900
sedative effect of medetomidine and its reversal by atipamezole in house musk shrews (suncus murinus).this study was undertaken to evaluate the sedative effect of medetomidine, an alpha 2-adrenoceptor agonist, and the counteractive effect of atipamezole, an antagonist to medetomidine, in house musk shrews (suncus murinus). two hundred, 300, 400, or 600 micrograms/kg of medetomidine was intraperitoneal injected into 89 house musk shrews. a sedative effect was produced in one to two minutes after injection. the dose-dependent prolongation of the sedative duration and the dose-dependent appearance ...19957705479
identification of chicken gnrh ii in brains of metatherian and early-evolved eutherian species of mammals.two molecular forms of gnrh (chicken gnrh ii and a second variant) are present in the brains of species from all the major vertebrate groups. in mammals, two forms are present in metatherian species and early-evolved eutherian species, but chicken gnrh ii has not been identified in more advanced eutherian species. we investigated the nature of gnrh molecular forms in several early-evolved mammalian species, using high performance liquid chromatography and radioimmunoassay with specific gnrh anti ...19947716279
relationships between morphometric and mitochondrial dna differentiation in laboratory strains of musk shrews (suncus murinus).morphometric differentiation among six strains of musk shrews (suncus murinus) originating in bangladesh (ban), sri lanka (sri), and four japanese areas, nagasaki (nag), okinawa island (oki), tokunoshima island (tku), and taramajima island (tr), was examined by use of skull and external measurements. these data were compared with mitochondrial dna (mtdna) differentiation previously reported. significant sexual dimorphism was observed in all morphometric characters of the six strains, except for ...19957772382
blockade of motion- and cisplatin-induced emesis by a 5-ht2 receptor agonist in suncus murinus.1. the effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (dol), a 5-hydroxytryptamine 5-ht2a/5-ht2c receptor agonist, on motion- and cisplatin-induced emesis were studied in suncus murinus. subcutaneous injection of dol, 30 min prior to the emetic stimuli, dose-dependently blocked the emesis induced by motion sickness and cisplatin (20 mg kg-1, i.p.) with estimated id50 values of 640 and 780 micrograms kg-1, respectively. 2. alpha-methyl-5-hydroxytryptamine (alpha-me-5-ht), a periph ...19957780647
a novel dodecadepsipeptide, cereulide, is an emetic toxin of bacillus cereus.a vacuole-formation substance, cereulide of bacillus cereus, is an emetic toxin in animals. both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in suncus murinus, a new animal model of emesis. vagotomy or a 5-ht3 receptor antagonist completely abolished this emetic effect. therefore, cereulide causes emesis through the 5-ht3 receptor and stimulation of the vagus afferent. we also found that our purified cereulide caused swelling of mitochondria of hep ...19957781985
evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. a survey of its subcellular distribution in the livers of various representatives of the classes mammalia, aves and amphibia.as part of a wider study on the molecular evolution of alanine:glyoxylate aminotransferase 1 (agt1) intracellular compartmentalization, we have determined the subcellular distribution of immunoreactive agt1, using postembedding protein a-gold immunoelectron microscopy, in the livers of various members of the classes mammalia, aves, and amphibia. as far as organellar distribution is concerned, three categories could be distinguished. in members of the first category (type i), all, or nearly all, ...19947813517
phenotypic changes of aadc-only immunopositive premammillary neurons in the brain of laboratory shrew suncus murinus by systemic administration of monoamine precursors.after 5-hydroxy-l-tryptophan (5-htp) and l-3,4-dihydroxyphenylalanine (l-dopa) were injected i.p. in the laboratory shrew suncus murinus, immunocytochemical and immunofluorescence studies were conducted on continuous or same sections of the brain, using specific anti-tyrosine hydroxylase (th), anti-aromatic l-amino acid decarboxylase (aadc), anti-dopamine (da) and anti-serotonin (5-ht) antisera which were produced in our laboratory. the results of double-staining by the immunofluorescence method ...19947845627
morphogenesis of esophageal carcinoma induced by n-methyl-n'-nitro-n-nitrosoguanidine in the house musk shrew, suncus murinus (insectivora).the histological changes occurring in the esophageal mucosa of shrews (suncus murinus) after n-methyl-n'-nitro-n-nitrosoguanidine (mnng) treatment were investigated sequentially. six-week-old female shrews were given a 50 micrograms/ml mnng solution as drinking water for 30 weeks, and 5 selected at random were killed at 10 and 20 weeks of age, and thereafter at 5-week intervals until 45 weeks of age. controls were killed at 45 weeks of age. the mnng-induced esophageal lesion in shrews began from ...19947852183
mating alters gonadotropin-releasing hormone cell number and content.female musk shrews (suncus murinus) are induced ovulators, which lack a behavioral and ovarian estrous cycle. females mate the first time they are introduced to a male, but a second or third mating, at least 24 h later, is usually required to induce ovulation. because gnrh-immunoreactive (gnrh-ir) cell numbers increase during and after exposure to a male, we hypothesized that mating promotes synthesis of this important peptide. to test this hypothesis, we examined changes in gnrh-ir cell number ...19957895675
occipital roof development in the japanese musk shrew, suncus murinus.the occipital squama of the japanese musk shrew, suncus murinus, consists only of membrane bone which arises from the periosteal bony band of the supraoccipital cartilage. no cartilaginous tectum posterius, generally forming the dorsal border to the foramen magnum, was found in the developing chondrocranium. also additional intramembranous ossification centres were occasionally observed, and could be interpreted as being the primordium of the interparietal bone. these observations indicate that ...19947961150
testosterone implants in specific neural sites activate female sexual behaviour.sexual behaviour in most female mammals is regulated by oestrogen, often acting synergistically with progesterone. moreover, the most important neural site of action for oestradiol is the ventromedial nucleus. in the female musk shrew, suncus murinus, testosterone (t) activates sexual behaviour. virgin females first engage in copulatory behaviour many hours in advance of follicular development and ovulation, when plasma oestradiol levels are very low. testosterone, produced by the ovaries and th ...19947987373
induction of emesis in suncus murinus by pyrogallol, a generator of free radicals.1. we investigated whether or not pyrogallol, a generator of free radicals, is emetogenic in suncus murinus, the house musk shrew. pyrogallol (i.p.) caused dose-dependent emesis in suncus with an ed50 value of 77.3 mg kg-1. at a dose of 128 mg kg-1, all suncus vomited with mean latency of 18.8 +/- 5.2 min and the number of vomiting episodes was 8.6 +/- 2.9. 2. the prophylactic effects of n-(2-mercaptopropionyl)-glycine (mpg), an antioxidant, and tropisetron, a 5-hydroxytryptamine3 (5-ht3) recept ...19948004387
antiemetic effects of serotonergic 5-ht1a-receptor agonists in suncus murinus.the antiemetic effects of six serotonergic 5-ht1a-receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetrarin (8-oh-dpat), 4-(4-[4-(2-pyrimidinyl)piperazin-1-yl]butyl)-2,3,4,5- tetrahydro-1,4-benzoxazepine-3,5-dione (sun8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in suncus murinus. subcutaneous injection of all six agonists completely and dose-dependently suppressed motion-induced emesis. pretreatment with 8-oh-dpat or sun8399 dose-dependently ...19948028227
absence of emetic effects of morphine and loperamide in suncus murinus.the house musk shrew suncus murinus recently has been introduced for the study of emesis. we investigated the emetic effects of the opioids morphine (0.1-21.5 mg/kg i.p.) and loperamide (0.01-10 mg/kg i.p.) and found a complete lack of emetogenic potential. nicotine, however, dose dependently induced vomiting in the suncus with an ed50 of 8.8 mg/kg s.c. and a 100% incidence at 20 mg/kg. this drug-induced vomiting was reduced by morphine or loperamide: ed50 values obtained were 1.2 mg/kg i.p. for ...19948045273
electrophysiological properties of suncus (suncus murinus) cardiac muscle.1. electrophysiological properties of cardiac muscle in suncus murinus were compared with those of rat and guinea pig. 2. the resting potential and resting potassium permeability were smallest in suncus heart. 3. the action potential duration in suncus was also shortest, and effects of tetraethylammonium suggested that transient outward current is well developed in suncus. 4. elicitation of slow response was very difficult in suncus, suggesting poor development of the calcium channel.19938102963
follicular growth rate and lack of influence of oestradiol valerate, testosterone propionate and aminoglutethimide phosphate on ovarian follicular development in the musk shrew, suncus murinus l.growth rate of follicles and effects of administration of oestradiol valerate (ev), testosterone propionate (tp) and aminoglutethemide phosphate (agp) on the development of ovarian follicles of the adult musk shrew were investigated. the follicular growth rate was estimated by mitotic index before and 2 hr after colchicine treatment to the shrews. mitotic index of granulosa cells increased linearly with the increase in the follicular diameter. the calculated mean duration of mitosis was 0.48 hr. ...19938112760
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