Publications

inhibition of peptide bf-30 on influenza a virus infection in vitro/vivo by causing virion membrane fusion.	influenza a virus is a leading cause of mortality in humans and poses a global health emergency due to its newly adapted and resistant strains. thus, there is an urgency to develop novel anti-influenza drugs. peptides are a type of biological molecule having a wide range of inhibitory effects against bacteria, fungi, viruses and cancer cells. the prospects of several peptides and their mechanisms of action have received significant attention. bf-30, a 30 amino acid residue peptide isolated from ...	2019	30447229
incidence of snakebites in 3 different geographic regions in thua thien hue province, central vietnam: green pit vipers and cobras cause the majority of bites.	the annual incidence of snakebites in vietnam is not known and only few publications about snakebite envenoming and medically relevant snakes can be found in english language literature. the present community-based surveys provide data on incidence of snakebites in three different geographic regions of thua thien hue (tt hue) province, central vietnam and snake species responsible for bites in this region.	2018	30448540
rapid identification of common medicinal snakes and their adulterants using the bar-hrm analysis method.	effective identification methods for snake species are lacking, exacerbating the extermination of medicinal and commercially valuable snake species. hence, it is imperative to find fast and reliable methods to distinguish snake samples available on the market. seventy-three samples from four families belonging to 13 genera were collected in china and found to contain common medicinal snakes and their adulterants. cytochrome oxidase i (coi) was utilized as a dna barcode to analyse these common sn ...	2019	30686100
phospholipase a2 from krait bungarus fasciatus venom induces human cancer cell death in vitro.	snake venoms are the complex mixtures of different compounds manifesting a wide array of biological activities. the venoms of kraits (genus bungarus, family elapidae) induce mainly neurological symptoms; however, these venoms show a cytotoxicity against cancer cells as well. this study was conducted to identify in bungarus fasciatus venom an active compound(s) exerting cytotoxic effects toward mcf7 human breast cancer cells and a549 human lung cancer cells.	2019	31824756
extraction of α-neurotoxins from equine plasma by receptor based affinity purification.	venoms were first identified as potential doping agents by the racing industry in 2007 when three vials of cobra venom were seized during an inspection of a stable at keeneland racecourse in the usa. venoms are a complex mixture of proteins, peptides, and other substances with a wide range of biological effects, including inhibiting the transmission of nervous and muscular impulses. as an example of this, cobratoxin, an α-neurotoxin found in cobra venom, is claimed to be an effective treatment f ...	2020	32246898
comparative venom proteomics of banded krait (bungarus fasciatus) from five geographical locales: correlation of venom lethality, immunoreactivity and antivenom neutralization.	the banded krait, bungarus fasciatus is a medically important venomous snake in asia. the wide distribution of this species in southeast asia and southern china indicates potential geographical variation of the venom which may impact the clinical management of snakebite envenomation. this study investigated the intraspecific venom variation of b. fasciatus from five geographical locales through a venom decomplexing proteomic approach, followed by toxinological and immunological studies. the veno ...	2020	32278639
snake cathelicidin derived peptide inhibits zika virus infection.	zika virus (zikv) is a mosquito-borne virus belonging to the genus flavivirus and has reemerged in recent years with epidemic potential. zikv infection may result in severe syndromes such as neurological complications and microcephaly in newborns. therefore, zikv has become a global public health threat and currently there is no approved specific drug for its treatment. animal venoms are important resources of novel drugs. cathelicidin-bf (bf-30) is a defensive peptide identified from bungarus f ...	2020	32849457