Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| sodium beta-artelinate--a new potential gametocytocide. | the water-soluble artemisinin analogue sodium beta-artelinate, a fast-acting blood schizontocide, was evaluated for gametocytocidal action against simian malaria plasmodium cynomolgi b, and a single dose of the compound has been found to be an effective gametocytocide by both oral and intravenous routes. the compound was able to sterilize the circulating gametocytes in rhesus monkey, resulting in loss of mosquito infectivity and oocyst development in the anopheles stephensi. however, no sporonto ... | 1996 | 8631376 |
| poly iclc inhibits plasmodium cynomolgi b malaria infection in rhesus monkeys. | prophylatic treatment with a single dose of 1.0 or 2.0 mg/kg (body weight) of polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly iclc), a potent interferon (ifn) inducer and immune enhancer, 18 h before intravenous inoculation of sporozoites (1.04 x 10(5)-0.70 x 10(6) sporozoites) of plasmodium cynomolgi b in the rhesus monkey, completely abolished the infectivity of sporozoites. the inhibitory effect of poly iclc is dose dependent in monkeys infected wit ... | 1996 | 8640451 |
| histochemical changes in host tissues from plasmodium cynomolgi b infected rhesus monkey (macaca mulatta). | plasmodium cynomolgi b has been used to infect the rhesus monkey to study the histochemical changes (lipid infiltration, glycogen, protein, dna and rna) in liver, kidney and spleen during early (exoerythrocytic) and late (chronic) stages of malarial infection. infected liver showed significant lipid infiltration during exoerythrocytic and erythrocytic (acute phase) stage of infection. kidney showed lipid deposition during acute phase of infection while spleen sections were negative for lipid dep ... | 1996 | 8641716 |
| gametocytocidal activity of alpha/beta arteether by the oral route of administration. | arteether (alpha/beta) (a mixture of alpha and beta enantioners) has been reported to possess gametocytocidal activity against plasmodium cynomolgi b when the drug is given by the intramuscular route, but it would be preferable to use oral route therapy for gametocyte carriers. this is a report of a study of the gametocytocidal action of arteether administered by the oral route. the results indicate high levels of activity at 10 mg/kg in a single dose or in two divided doses when given orally. | 1996 | 8686787 |
| the plasmodium cynomolgi merozoite surface protein 1 c-terminal sequence and its homologies with other plasmodium species. | 1995 | 8719250 | |
| a shared genetic mechanism for melanotic encapsulation of cm-sephadex beads and a malaria parasite, plasmodium cynomolgi b, in the mosquito, anopheles gambiae. | a plasmodium-refractory strain of anopheles gambiae that melanizes ookinetes and intrathoracically inoculated cm-sephadex beads was mated to a plasmodium-susceptible strain that does not melanize the parasite or the beads. the f1 progeny were then backcrossed to the susceptible strain. backcross progeny were given a blood meal containing infective plasmodium cynomolgi b, and the parasites were allowed to develop for 6-7 days, at which time the infected mosquitoes were injected with cm-sephadex b ... | 1996 | 8948327 |
| in-vitro cultivation of exoerythrocytic stages of plasmodium cynomolgi in hepatocytes of macaca radiata. | hepatocytes from bonet monkey (macaca radiata) obtained by perfusion of a liver biopsy were infected in-vitro with plasmodium cynomolgi bastianellii sporozoites raised in anopheles stephensi. the development of exoerythrocytic (ee) stages was seen under phase contrast microscope and by giemsa staining. multinucleated ee-stages were seen in the cultured hepatocytes on day 7-8 post-sporozoite inoculation. | 1996 | 8952170 |
| sterile protection of monkeys against malaria after administration of interleukin-12. | an estimated 300-500 million new infections and 1.5-2.7 million deaths attributed to malaria occur annually in the developing world, and every year tens of millions of travelers from countries where malaria is not transmitted visit countries with malaria. because the parasites that cause malaria have developed resistance to many antimalarial drugs, new methods for prevention are required. intraperitoneal injection into mice of one dose of 150 ng (approximately 7.5 micrograms per kg body weight) ... | 1997 | 8986746 |
| quantitative trait loci for refractoriness of anopheles gambiae to plasmodium cynomolgi b. | the severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of parasite resistance to antimalarial drugs and mosquito resistance to insecticides. a strain of anopheles gambiae, normally a major vector for human malaria in africa, can encapsulate and kill the malaria parasites within a melanin-rich capsule in the mosquito midgut. genetic mapping revealed one major and two minor quantitative trait loci (qtls) for this encapsulation reaction. understanding such antiparas ... | 1997 | 9103203 |
| a genetic study of a melanization response to sephadex beads in plasmodium-refractory and -susceptible strains of anopheles gambiae. | a previously selected plasmodium-refractory strain of anopheles gambiae melanotically encapsulates many species of plasmodium. genetic studies of this strain have shown that this refractory phenotype is controlled by a limited number of genes, and the existence of two such genes, pif-b and pif-c, has been demonstrated. further work to determine the molecular basis for this mode of refractoriness led to the discovery that the host-parasite interaction is mimicked by the mosquito's response to car ... | 1997 | 9158056 |
| cloning and sequence analysis of a gene encoding an erythrocyte binding protein from plasmodium cynomolgi. | 1997 | 9364974 | |
| characterization of c-terminal merozoite surface protein-1 baculovirus recombinant proteins from plasmodium vivax and plasmodium cynomolgi as recognized by the natural anti-parasite immune response. | 1997 | 9364976 | |
| cloning and sequence analysis of the thrombospondin-related adhesive protein (trap) gene of plasmodium cynomolgi bastianelli. | 1997 | 9497063 | |
| phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate. | the phage-displayed peptide cgrvclrc (c15) has been isolated from a random library by affinity screening with the d14-3 monoclonal antibody, which was raised to the 42 kda c-terminal fragment of the major merozoite surface protein 1 of plasmodium vivax (pv42). in order to investigate the use of such mimotopes as possible vaccine components, we studied the antibody response in biozzi mice immunized with c15. high titers of antibodies cross-reacting with pv42 were generated and the ic50 of all imm ... | 1998 | 9504719 |
| baculovirus merozoite surface protein 1 c-terminal recombinant antigens are highly protective in a natural primate model for human plasmodium vivax malaria. | a successful anti-blood stage malaria vaccine trial based on a leading vaccine candidate, the major merozoite surface antigen-1 (msp1), is reported here. the trial was based on plasmodium cynomolgi, which is a primate malaria parasite which is highly analogous to the human parasite plasmodium vivax, in its natural host, the toque monkey, macaca sinica. two recombinant baculovirus-expressed p. cynomolgi msp1 proteins, which are analogous to the 42- and 19-kda c-terminal fragments of p. falciparum ... | 1998 | 9529073 |
| plasmodium inui is not closely related to other quartan plasmodium species. | plasmodium inui (halberstaedter and von prowazek, 1907), a malarial parasite of old world monkeys that occurs in isolated pockets throughout the celebes, indonesia, malaysia, and the philippines, has traditionally been considered to be related more closely to plasmodium malariae of humans (and its primate counterpart plasmodium brasilianum), than to other primate plasmodium species. this inference was made in part because of the similarities in the periodicities or duration of the asexual cycle ... | 1998 | 9576499 |
| high-level expression of plasmodium vivax apical membrane antigen 1 (ama-1) in pichia pastoris: strong immunogenicity in macaca mulatta immunized with p. vivax ama-1 and adjuvant sbas2. | the apical membrane antigen 1 (ama-1) family is a promising family of malaria blood-stage vaccine candidates that have induced protection in rodent and nonhuman primate models of malaria. correct conformation of the protein appears to be essential for the induction of parasite-inhibitory responses, and these responses appear to be primarily antibody mediated. here we describe for the first time high-level secreted expression (over 50 mg/liter) of the plasmodium vivax ama-1 (pv66/ama-1) ectodomai ... | 1999 | 9864194 |
| linkage of a gene causing malaria refractoriness to diphenol oxidase-a2 on chromosome 3 of anopheles gambiae. | an inbred line of the african malaria vector anopheles gambiae is refractory to development of malaria parasites. it is homozygous for a 4.3-kb sal i restriction fragment at the dox-a2 locus, whereas the parent population is polymorphic at this locus, and a susceptible line is homozygous for an alternate 3.85-kb fragment. the dox-a2 locus is located in the middle of chromosome 3r, in division 33b, and is tightly linked to a cluster of genes including dopa decarboxylase that are involved in the p ... | 1999 | 9988317 |
| rna helicase-related genes of plasmodium falciparum and plasmodium cynomolgi. | rna helicases play many essential roles including cell development and growth. using degenerate oligonucleotide primers designed to amplify dna fragments flanked by the highly conserved helicase motifs vldead and yihrig and genomic dnas from the malarial parasites as a template, we have cloned two putative rna helicase genes (546 and 540 bp) from p. falciparum and one gene (546 bp) from p. cynomologi. southern blot analysis revealed that these could be multiple and single-copy genes in p. falcip ... | 1999 | 10049705 |
| plasmodium vivax, p. cynomolgi, and p. knowlesi: identification of homologue proteins associated with the surface of merozoites. | we have identified a plasmodium vivax merozoite surface protein (msp) that migrates on sds-polyacrylamide gels at a mr of about 185 kda. this protein was recognized by a p. vivax monoclonal antibody (mab) that localizes the protein by immunofluorescence to the surface of merozoites and also immunoprecipitates this protein from np-40 detergent extracts of [35s]methionine metabolically radiolabeled p. vivax schizonts. the p. vivax msp does not become biosynthetically radiolabeled with [3h]glucoami ... | 1999 | 10072326 |
| studies on infections with the berok strain of plasmodium cynomolgi in monkeys and mosquitoes. | infections with the berok strain of plasmodium cynomolgi were induced in macaca mulatta, macaca fascicularis, macaca nemestrina, aotus lemurinus griseimembra, aotus azarae boliviensis, and saimiri boliviensis monkeys. transmission was obtained with sporozoites developing in anopheles peditaeniatus, anopheles maculatus, anopheles quadrimaculatus, anopheles culicifacies, and anopheles dirus mosquitoes. this strain of p. cynomolgi offers significant potential for a number of experimental studies. t ... | 1999 | 10219307 |
| the crystal structure of c-terminal merozoite surface protein 1 at 1.8 a resolution, a highly protective malaria vaccine candidate. | the c-terminal proteolytic processing product of merozoite surface protein 1 (msp1) appears essential for successful erythrocyte invasion by the malarial parasite, plasmodium. we have determined the crystal structure at 1.8 a resolution of a soluble baculovirus-recombinant form of the protein from p. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. the structure comprises two egf-like domains, and sequence comparisons strongly suggest that the same conformati ... | 1999 | 10230398 |
| plasmodium cynomolgi: transfection of blood-stage parasites using heterologous dna constructs. | 1999 | 10464040 | |
| azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys. | the spectrum of antimalarial activity of the new macrolide antibiotic azithromycin was evaluated against blood- and sporozoite-induced infections with a chloroquine-resistant strain of plasmodium yoelii nigeriensis (n-67) in swiss mice and with simian parasite plasmodium cynomolgi b in rhesus monkeys. against experimental rodent malaria, a 70 mg/kg/day dose showed curative blood-schizontocidal activity in a four-dose regimen administered orally from day 0 to day 3 or from day 2 to day 5 to mice ... | 2000 | 10631075 |
| demonstration of a persisting exo-erythrocytic cycle in plasmodium cynomolgi and its bearing on the production of relapses. 1948. | 2000 | 11196492 | |
| a class of potent antimalarials and their specific accumulation in infected erythrocytes. | during asexual development within erythrocytes, malaria parasites synthesize considerable amounts of membrane. this activity provides an attractive target for chemotherapy because it is absent from mature erythrocytes. we found that compounds that inhibit phosphatidylcholine biosynthesis de novo from choline were potent antimalarial drugs. the lead compound, g25, potently inhibited in vitro growth of the human malaria parasites plasmodium falciparum and p. vivax and was 1000-fold less toxic to m ... | 2002 | 11847346 |
| merozoite surface protein-9 of plasmodium vivax and related simian malaria parasites is orthologous to p101/abra of p. falciparum. | plasmodium vivax merozoite surface protein-9 (pvmsp-9) is characterized here along with orthologues from the related simian malarias plasmodium cynomolgi and plasmodium knowlesi. we show that although the corresponding msp-9 proteins do not have acidic-basic repeated amino acid (aa) motifs, they are related to the plasmodium falciparum acidic-basic repeat antigen (abra) also known as p101. recognition of this new interspecies plasmodium msp family stems from the prior identification of related m ... | 2002 | 11849704 |
| immunogenicity and protective efficacy of three dna vaccines encoding pre-erythrocytic- and erythrocytic-stage antigens of plasmodium cynomolgi in rhesus monkeys. | although several malaria vaccine candidate antigens have been identified, the most suitable methods for their delivery are still being investigated. in this regard, direct immunization with dna encoding these vaccine target antigens is an attractive alternative. here, we have investigated the immune responses to dna immunization with three major vaccine target antigens: the apical membrane antigen-1 and the 19-kda c-terminal fragment of merozoite surface protein-1 from the erythrocytic stage, an ... | 2002 | 12208604 |
| isolation and characterization of an eif-4a homologue from plasmodium cynomolgi. | 2002 | 12387853 | |
| cytokine responses during acute simian plasmodium cynomolgi and plasmodium knowlesi infections. | experimental infection of non-human primates with simian malaria parasites offers a controlled system to study malarial immunity. plasmodium cynomolgi (p. vivax-like) and p. knowlesi (p. falciparum-like) infections in the rhesus monkey were used as a model to test the hypothesis that initial acute infection stimulates type 1/pro-inflammatory cytokine expression followed by a gradual type 2/anti-inflammatory response upon re-infection. this study analyzed cytokine gene expression (interleukin-12, ... | 2002 | 12518848 |
| [practicability of ifat using plasmodium cynomolgi and plasmodium falciparum antigens in different malarious areas]. | to compare the practicability of ifat in different malarious areas using plasmodium cynomolgi(p.c.) and plasmodium falciparum(p.f.) antigens. | 2000 | 12567477 |
| blood schizontocidal activity of wr 238605 (tafenoquine) against plasmodium cynomolgi and plasmodium fragile infections in rhesus monkeys. | a new 8-aminoquinoline antimalarial wr 238605 (tafenoquine), developed initially as a primaquine alternative for prevention of plasmodium vivax relapses was evaluated for blood schizontocidal activity against two simian malaria infections namely plasmodium cynomolgi b and plasmodium fragile in rhesus monkeys. treatment with wr 238605 at a dose of 3.16 mg(base)/kg/day x 7 days cured established trophozoite induced infections in monkeys with both these parasites. the lower dose of 1.00 mg/kg/day c ... | 2003 | 12711101 |
| replication fork-stimulated eif-4a from plasmodium cynomolgi unwinds dna in the 3' to 5' direction and is inhibited by dna-interacting compounds. | plasmodium cynomolgi dead-box dna helicase 45 (pcddh45) is an atp-dependent dna-unwinding enzyme with intrinsic dna-dependent atpase activity and is highly homologous to eif-4a. in this study, we have further characterized and tested the effect of various dna-interacting compounds on the dna-unwinding activity of pcddh45. the results show that pcddh45 translocates in the 3' to 5' direction along the bound strand, a replication fork-like structure of the substrate stimulates its dna-unwinding act ... | 2003 | 12745261 |
| the development of exoerythrocytic stages of plasmodium inui shortti in new world monkeys. | attempts are being made to adapt old world monkey malarial parasites to new world monkeys for vaccine and molecular studies. several of these (plasmodium cynomolgi berok, plasmodium fragile, and plasmodium knowlesi) grow readily but have failed to produce infective gametocytes. plasmodium gonderi and plasmodium fieldi develop in the liver after sporozoite inoculation but have failed to establish infection in the erythrocyte. anopheles dirus mosquitoes infected with plasmodium inui shortti by fee ... | 2003 | 12880277 |
| further notes on the tissue stages of plasmodium cynomolgi. | 1954 | 13157157 | |
| [pathological-immunity relations between parasite and host in macacus rhesus inoculated with blood infected with plasmodium cynomolgi, later splenectomized and repeatedly reinfected with homologous strain]. | 1954 | 13204670 | |
| absence of cross-immunity between plasmodium cynomolgi and plasmodium gonderi. | 1955 | 13306283 | |
| additional notes on the tissue stages of plasmodium cynomolgi. | 1957 | 13443015 | |
| partial inhibitory effect of plistophora culicis on the sporogonic cycle of plasmodium cynomolgi in anopheles stephensi. | 1958 | 13504228 | |
| transmission of the m strain of plasmodium cynomolgi to man. | 1961 | 13694174 | |
| the exoerythrocytic cycle of plasmodium cynomolgi and p. cynomolgi bastianellii in the rhesus monkey. | 1960 | 13697716 | |
| the transmission of plasmodium cynomolgi to man. | 1961 | 13748031 | |
| vivax-type malaria parasite of macaques transmissible to man. | transmission of plasmodium cynomolgi bastianellii from rhesus monkeys to two human subjects by anopheles freeborni and the occurrence of attacks of malaria in two other laboratory workers not exposed to human malaria suggests the existence of an animal reservoir of infection complicating malaria control and eradication. | 1960 | 13821129 |
| blood loss and replacement in plasmodial infections. iii. plasmodium cynomolgi, plasmodium gonderi and plasmodium knowlesi in macaca mulatta mulatta, the rhesus monkey. | 1960 | 13847844 | |
| man to man transfer of two strains of plasmodium cynomolgi by mosquito bite. | 1962 | 13880974 | |
| effect of certain drugs on exoerythrocytic parasites of plasmodium cynomolgi. | 1962 | 13891113 | |
| clinical and physiological responses in sporozoite-induced b strain plasmodium cynomolgi and plasmodium vivax infections in normal volunteers. | 1962 | 13927674 | |
| malaria in man. infection by plasmodium vivax and the b strain of plasmodium cynomolgi. | 1963 | 13927675 | |
| the activity of a repository form of 4,6-diamino-1(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine against infections with plasmodium cynomolgi. | 1963 | 14044759 | |
| the localization of infective pre-erythrocytic forms of plasmodium cynomolgi. | 1964 | 14128583 | |
| transmission of a new strain of plasmodium cynomolgi to man. | 1965 | 14259487 | |
| the suceptibility of malayan anophelines to plasmodium cynomolgi bastianellii. | 1963 | 14274297 | |
| potentiation of activity of diaphenylsulfone and pyrimethamine against plasmodium gallinaceum and plasmodium cynomolgi bastianellii. | in view of the fact that diaphenylsulfone has been shown to have low schizontocidal activity against plasmodium gallinaceum and to lead to resistance in strains of p. cynomolgi, investigations were undertaken into the joint action of diaphenylsulfone and pyrimethamine against p. gallinaceum in chicks and p. cynomolgi bastianellii in monkeys. these drugs were assayed separately and in various combinations. it was found that at certain dose levels combination of the two drugs led to potentiation o ... | 1964 | 14278006 |
| quantitative trait loci in anopheles gambiae controlling the encapsulation response against plasmodium cynomolgi ceylon. | anopheles gambiae females are the world's most successful vectors of human malaria. however, a fraction of these mosquitoes is refractory to plasmodium development. l3-5, a laboratory selected refractory strain, encapsulates transforming ookinetes/early oocysts of a wide variety of plasmodium species. previous studies on these mosquitoes showed that one major (pen1) and two minor (pen2, pen3) autosomal dominant quantitative trait loci (qtls) control the melanotic encapsulation response against p ... | 2003 | 14577840 |
| dna prime-protein boost immunization in monkeys: efficacy of a novel construct containing functional domains of plasmodium cynomolgi cs and trap. | we report the efficacy of a bimodal immunization regimen that involved priming with naked dna (multiple doses) followed by a booster with recombinant protein in rhesus monkeys with a chimeric construct containing the n-terminus of thrombospondin-related adhesive protein and the c-terminus of circumsporozoite protein of plasmodium cynomolgi. the vaccinated animals developed high titer antibodies against the chimeric antigen, the two components of the hybrid and the native proteins of sporozoites. ... | 2003 | 14642309 |
| studies on relapses in blood-induced infections from plasmodium malariae and plasmodium cynomolgi. | 1950 | 14804091 | |
| a strain of monkey malaria (plasmodium cynomolgi) made resistant to proguanil (paludrine). | 1951 | 14855617 | |
| morphological changes in plasmodium cynomolgi following proguanil, sulphadiazine, and mepacrine therapy. | 1951 | 14855619 | |
| chemotherapeutic and other studies on the pre-erythrocytic forms of simian malaria (plasmodium cynomolgi). | 1952 | 14942880 | |
| prodrugs of bisthiazolium salts are orally potent antimalarials. | we created neutral antimalarial prodrugs that deliver bisthiazolium compounds with antimalarial activity in the nanomolar range. these drugs primarily affect early intraerythrocytic stages through rapid, nonreversible cytotoxicity. the compounds are suitable for both parenteral and oral use and plasma promotes rapid conversion of the prodrug into the drug. we demonstrate that very low doses offer protection in a murine model of malaria. the drugs show great potential for curing high parasitemia ... | 2004 | 15492221 |
| transcriptome profiles of host gene expression in a monkey model of human malaria. | we used human microarrays to examine gene expression in a rhesus monkey model of human plasmodium vivax malaria (p. cynomolgi in macaca mulatta). whole-blood cells were collected for extraction of rna before infection, during both the initial liver phase of infection and bloodstream infection, and during the course of 2 bloodstream relapses. clustering analysis showed that similarities in gene expression were greater at similar stages of the protocol for the 2 different monkeys than for the same ... | 2004 | 15633100 |
| structure identification and prophylactic antimalarial efficacy of 2-guanidinoimidazolidinedione derivatives. | the reported synthetic procedure of wr182393, a 2-guanidinoimidazolidinedione derivative with high prophylactic antimalarial activity, was found to be a mixture of three closely related products. poor solubility of wr182393 in both water and organic solvents and its impractical synthetic method have made the purification and structure identification of the reaction mixture a highly challenging task. the problems were circumvented by prodrug approach involving carbamate formation of the mixture, ... | 2005 | 15653337 |
| [induction of protective immunity in rhesus monkey by inoculation with recombinant fusion protein of cholera toxin b subunit-multivalent epitopes of plasmodium falciparum]. | rhesus monkeys (5 in each group) were inoculated with recombinant fusion protein of cholera toxin b subunit and multi-valent epitopes of plasmodium falciparum intranasal or intramuscular (i.m.). immune-responses and protective effect were evaluated. the antibody titer (geometry mean) against ctb reached 1:512 (intranasal) and 1:10000 (i.m.) 14 day after 3rd immunization, and antibodies against p. falciparum were also elucidated, the titers in i.m. group were also significantly higher than that i ... | 2004 | 15968980 |
| studies on two strains of plasmodium cynomolgi in new world and old world monkeys and mosquitoes. | infections that cause the gombak and smithsonian strains of plasmodium cynomolgi were induced in macaca mulatta, aotus lemurinus griseimembra, aotus nancymai, and saimiri boliviensis monkeys. transmission of the gombak strain to aotus spp. monkeys was obtained by the injection of sporozoites dissected from the salivary glands of experimentally infected anopheles dirus and by the bites of infected an. dirus and anopheles farauti mosquitoes. two s. boliviensis monkeys were infected via the injecti ... | 2005 | 15986601 |
| the reticulocyte binding proteins of plasmodium cynomolgi: a model system for studies of p. vivax. | 2005 | 15990180 | |
| plasmodium cynomolgi: gametocytocidal activity of the anti-malarial compound cdri 80/53 (elubaquine) in rhesus monkeys. | the gametocytocidal action of a new enamine analogue of primaquine, elubaquine (compound cdri 80/53, bulaquine), has been evaluated against plasmodium cynomolgi b in rhesus monkeys. colony bred anopheles stephensi mosquitoes were fed on gametocyte carrying rhesus monkeys prior to and at varying intervals after oral administration of a single dose of elubaquine at doses ranging between 0.63 and 5.00 mg/kg. complete loss of oocyst development and mosquito infectivity was observed within 24 h after ... | 2005 | 16005457 |
| merozoite surface protein 1 of plasmodium vivax induces a protective response against plasmodium cynomolgi challenge in rhesus monkeys. | the 42-kda fragment of the merozoite surface protein 1 (msp-1(42)) is a leading candidate for the development of a vaccine to control malaria. we previously reported a method for the production of plasmodium vivax msp-1(42) (pvmsp-1(42)) as a soluble protein (s. dutta, l. w. ware, a. barbosa, c. f. ockenhouse, and d. e. lanar, infect. immun. 69:5464-5470, 2001). we report here a process to manufacture the same pvmsp-1(42) protein but as an insoluble inclusion body-derived protein which was then ... | 2005 | 16113314 |
| 8-(1-naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro (4.5) decane, a new 1,2,4-trioxane effective against rodent and simian malaria. | a new series of 8-(1-aryl-vinyl)-6,7,10-trioxaspiro [4.5] decanes 7a-e and 3-(1-aryl-vinyl)-l,2,5-trioxaspiro [5.5] undecanes 8a-e have been prepared and screened against multi-drug resistant plasmodium yoelii in mice. 8-(1-naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro [4.5] decane 7b, the most active trioxane of the series, has also shown promising activity against plasmodium cynomolgi in rhesus monkeys. | 2006 | 16275088 |
| hydrolytic enzyme activity in rhesus monkey placenta during early gestational malaria: histochemical studies. | early gestational malaria is found to be more fatal than late gestational infection but the pathophysiology of early gestational placenta, the maternofoetal organ responsible for maintenance of pregnancy, remains unexplored. present study dealing with hydrolytic enzymes in early gestational placenta of rhesus monkeys during plasmodium cynomolgi infection was anticipated to provide a better insight into the functional impairment of this organ during early gestational maternal malaria. | 2005 | 16457382 |
| observations on the exoerythrocytic stages of different isolates of plasmodium cynomolgi in hepatocytes of new world aotus and saimiri monkeys. | sporozoites of 3 isolates of plasmodium cynomolgi dissected from the salivary glands of anopheles dirus and anopheles quadrimaculatus were injected intravenously into 9 new world monkeys. liver stage parasites were demonstrated in all 9 animals; 7 of these animals also produced blood stages after prepatent periods of 9 to 23 days. | 2006 | 16629341 |
| [molecular identification of naturally acquired plasmodium knowlesi infection in a human case]. | to confirm the diagnosis of a human case with atypical vivax-malaria from yunnan province by molecular technique. | 2006 | 17094597 |
| synthesis and antimalarial activity of new 1,12-bis(n,n'-acetamidinyl)dodecane derivatives. | amidoxime and o-substituted derivatives of the bis-alkylamidine 1,12-bis(n,n'-acetamidinyl)dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. the bis-o-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration. | 2007 | 17123818 |
| cross-reactivity studies of an anti-plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation. | apical membrane antigen 1 (ama1) has an important, but as yet uncharacterised, role in host cell invasion by the malaria parasite, plasmodium. the protein, which is quite conserved between plasmodium species, comprises an ectoplasmic region, a single transmembrane segment and a small cytoplasmic domain. the ectoplasmic region, which can induce protective immunity in animal models of human malaria, is a leading vaccine candidate that has entered clinical trials. the monoclonal antibody f8.12.19, ... | 2007 | 17229439 |
| new adamantane-based spiro 1,2,4-trioxanes orally effective against rodent and simian malaria. | new 6-arylvinyl- and 6-adamantylvinyl-substituted 1,2,4-trioxanes (13a-g and 14a,b) have been prepared and evaluated for antimalarial activity against multidrug resistant plasmodium yoelii nigeriensis in mice by both oral and intramuscular routes. while all the 6-arylvinyl-substituted trioxanes, 13a-f, showed promising activity, none of the 6-adamantylvinyl-substituted trioxanes, 13g and 14a,b, exhibited significant activity. trioxane, 13f, the most active compound of the series, provided 100% a ... | 2007 | 17266204 |
| recent independent evolution of msp1 polymorphism in plasmodium vivax and related simian malaria parasites. | the plasmodium msp-1 is a promising malaria vaccine candidate. however, the highly polymorphic nature of the msp-1 gene (msp1) presents a potential obstacle for effective vaccine development. to investigate the evolutionary history of msp1 polymorphism in p. vivax, we construct phylogenetic trees of msp1 from p. vivax and related monkey malaria parasite species. all p. vivax msp1 alleles cluster in the p. vivax lineage and are not distributed among other species. similarly, all p. cynomolgi msp1 ... | 2007 | 17706800 |
| oxidoreductases in early gestational monkey placenta during maternal malarial infection: histochemical localisation. | early gestational malaria is more deleterious than late gestational infection. still the pathophysiology of maternofoetal organ--the placenta in malaria remains almost unexplored during early gestation. present study dealing with oxidoreductases in early gestational placenta during maternal malarial infection of plasmodium cynomolgi bastianellii in rhesus monkeys was anticipated to provide a better insight into the functional impairment of this organ leading to foetal abnormalities. | 2007 | 17722865 |
| malaria causal prophylactic activity of imidazolidinedione derivatives. | a series of acid-stable carboxamide derivatives of 2-guanidinoimidazolidinedione (5a-c and 6a-c) were prepared as potential malaria prophylactic and radical cure agents. the new compounds showed moderate to good causal prophylactic activity in mice infected with plasmodium yoelii sporozoites. three compounds were further tested for causal prophylactic activity in rhesus monkeys infected with plasmodium cynomolgi sporozoites, and all showed a delay in patency from 13 to 40 days at 30 mg/kg/day x ... | 2007 | 17967003 |
| development of resistance to chlorguanide (paludrine) during treatment of infections with plasmodium cynomolgi. | 1949 | 18114537 | |
| exoerythrocytic stages of plasmodium cynomolgi in the macaca mulatta. | 1949 | 18124332 | |
| biochemical and immunological characterization of e. coli expressed 42 kda fragment of plasmodium vivax and p. cynomolgi bastianelli merozoite surface protein-1. | plasmodium vivax is one of the most widely distributed human malaria parasites and due to drug-resistant strains, its incidence and prevalence has increased, thus an effective vaccine against the parasites is urgently needed. one of the major constraints in developing p. vivax vaccine is the lack of suitable in vivo models for testing the protective efficacy of the vaccine. p. vivax and p. cynomolgi bastianelli are the two closely related malaria parasites and share a similar clinical course of ... | 2007 | 18320841 |
| detection of new babesia microti-like parasites in a rhesus monkey (macaca mulatta) with a suppressed plasmodium cynomolgi infection. | a new type of piroplasm, phylogenetically closest to babesia microti-like parasites previously detected in eurasian red squirrels (sciurus vulgaris orientis), was identified in a rhesus monkey (macaca mulatta) imported from china. after challenge with plasmodium cynomolgi m strain blood-stage parasites, the rhesus monkey repeatedly showed markedly reduced levels of plasmodium parasitemia when compared with animals not infected with this organism. | 2008 | 18385363 |
| transmission of different strains of plasmodium cynomolgi to aotus nancymaae monkeys and relapse. | forty-four splenectomized aotus nancymaae monkeys were infected with 6 different strains of plasmodium cynomolgi, 11 via trophozoites and 33 via sporozoites. sporozoites from anopheles dirus, anopheles freeborni, anopheles gambiae, anopheles maculatus, and anopheles stephensi resulted in prepatent periods ranging from 9 to 39 days (median of 15 days). importantly, relapse was demonstrated in 5 of 5 sporozoite-induced infections with the rossan strain following treatment with chloroquine. | 2009 | 18788885 |
| tissue forms of a malaria parasite, plasmodium cynomolgi. | 1948 | 18858716 | |
| the exoerythrocytic parasites of plasmodium cynomolgi. | 1948 | 18865440 | |
| the pre-erythrocytic development of plasmodium cynomolgi and plasmodium vivax. | 1948 | 18865442 | |
| demonstration of a persisting exo-erythrocytic cycle in plasmodium cynomolgi and its bearing on the production of relapses. | 1948 | 18865981 | |
| resistance to proguanil in a mammalian malaria parasite, plasmodium cynomolgi. | 1948 | 18894194 | |
| malaria chemotherapy; the response of sporozoite-induced infections with plasmodium cynomolgi to various antimalarial drugs. | 1948 | 18934432 | |
| malaria chemotherapy; the response of trophozoite-induced infections with plasmodium cynomolgi to various antimalarial drugs. | 1948 | 18938343 | |
| statistical model to evaluate in vivo activities of antimalarial drugs in a plasmodium cynomolgi-macaque model for plasmodium vivax malaria. | preclinical animal models informing antimalarial drug development are scarce. we have used asexual erythrocytic plasmodium cynomolgi infections of rhesus macaques to model plasmodium vivax during preclinical development of compounds targeting parasite phospholipid synthesis. using this malaria model, we accumulated data confirming highly reproducible infection patterns, with self-curing parasite peaks reproducibly preceding recrudescence peaks. we applied nonlinear mixed-effect (nlme) models, es ... | 2009 | 19015340 |
| methylparaben in anopheles gambiae s.l. sugar meals increases longevity and malaria oocyst abundance but is not a preferred diet. | the antimicrobial and antifungal chemical methylparaben (methyl-4-hydroxybenzoate) was added to the adult sucrose diet of anopheles gambiae and anopheles arabiensis, and its effect on longevity was determined. in all cases, significant increases in longevity were observed when 0.2% (w/v) methylparaben was added to meals that were refreshed weekly. when fresh sugar diet was refreshed daily, no increase in longevity was observed due to methylparaben suggesting that the effect of methylparaben is t ... | 2009 | 19041323 |
| evidence for strain-specific protective immunity against blood-stage parasites of plasmodium cynomolgi in toque monkey. | we have conducted experiments to test the induction of strain-specific protective immunity against plasmodium cynomolgi infections in toque monkeys. plasmodium cynomolgi is closely related biologically and genetically to the human malaria parasite, p. vivax. two groups of monkeys were immunized against either of two strains of p. cynomolgi, namely pcceylon and pc746, by giving two successive drug-cured infections with asexual blood-stage parasites of one or the other strain, 12-weeks apart. to t ... | 2008 | 19067844 |
| rapid resolution liquid chromatography-mass spectrometry determination of sar97276 in monkey matrices. pharmacokinetics in rhesus monkey infected by plasmodium cynomolgi. | since several years, we developed a new class of antimalarial drugs targeting the phospholipid metabolism of the plasmodium falciparum malaria parasite. the bis-thiazolium compound, sar97276, is the lead compound and is now in clinical development. in this paper, we applied the fast rapid resolution liquid chromatography-mass spectrometry technique to the analysis of sar97276 in monkey matrices. the sample pre-treatment procedure involved an acidic precipitation of proteins followed by solid-pha ... | 2009 | 19303732 |
| altered immune responses in rhesus macaques co-infected with siv and plasmodium cynomolgi: an animal model for coincident aids and relapsing malaria. | dual epidemics of the malaria parasite plasmodium and hiv-1 in sub-saharan africa and asia present a significant risk for co-infection in these overlapping endemic regions. recent studies of hiv/plasmodium falciparum co-infection have reported significant interactions of these pathogens, including more rapid cd4+ t cell loss, increased viral load, increased immunosuppression, and increased episodes of clinical malaria. here, we describe a novel rhesus macaque model for co-infection that supports ... | 2009 | 19774084 |
| orangutans not infected with plasmodium vivax or p. cynomolgi, indonesia. | after orangutans in indonesia were reported as infected with plasmodium cynomolgi and p. vivax, we conducted phylogenetic analyses of small subunit ribosomal rna gene sequences of plasmodium spp. we found that these orangutans are not hosts of p. cynomolgi and p. vivax. analysis of >or=1 genes is needed to identify plasmodium spp. infecting orangutans. | 2009 | 19861067 |
| suppression of plasmodium cynomolgi in rhesus macaques by coinfection with babesia microti. | both plasmodium and babesia species are intraerythrocytic protozoans that infect a wide range of hosts, including humans, and they elicit similar inflammatory responses and clinical manifestations that differ markedly in severity. we recently reported that a rhesus macaque that was chronically infected with babesia microti was able to control infection with plasmodium cynomolgi (a parasite of macaques with characteristics very similar to those of plasmodium vivax) better than naïve monkeys. to c ... | 2010 | 20048045 |
| asexual reproduction of plasmodium cynomolgi in rhesus monkeys. | 1947 | 20283800 | |
| evidence for negative selection on the gene encoding rhoptry-associated protein 1 (rap-1) in plasmodium spp. | assessing how natural selection, negative or positive, operates on genes with low polymorphism is challenging. we investigated the genetic diversity of orthologous genes encoding the rhoptry-associated protein 1 (rap-1), a low polymorphic protein of malarial parasites that is involved in erythrocyte invasion. we applied evolutionary genetic methods to study the polymorphism in rap-1 from plasmodium falciparum (n=32) and plasmodium vivax (n=6), the two parasites responsible for most human malaria ... | 2010 | 20363375 |
| studies of plasmodium cynomolgi in the rhesus monkey, macaca mulatta. | 1946 | 21003024 | |
| a taqman real-time pcr assay for the detection and quantitation of plasmodium knowlesi. | the misdiagnosis of plasmodium knowlesi by microscopy has prompted a re-evaluation of the geographic distribution, prevalence and pathogenesis of this species using molecular diagnostic tools. in this report, a specific probe for p. knowlesi, that can be used in a previously described taqman real-time pcr assay for detection of plasmodium spp., and plasmodium falciparum, plasmodium vivax, plasmodium malariae and plasmodium ovale, was designed and validated against clinical samples. | 2010 | 21114872 |