Publications

[study of the effectiveness and tolerance of pevaryl 1 % milk in the treatment of mycoses of the external auditory meatus (author's transl)].	otomycoses account for approximately 20 % of cases of otitis externa. often unrecognised, they may be induced by various factors, in particular local antibiotic and corticosteroid therapy. the authors studied the effectiveness and tolerance of econazole (1 % milk) in the treatment of otomycoses. in each of 30 cases, a bacteriological examination was made before and one week after treatment, the latter consisting of the insertion into the e.a.m. of a wick soaked in econazole (1 % milk) every nigh ...	1978	718055
properties of a unique catalase isolated from aspergillus niger.	the properties of an unusual catalase isolated from aspergillus niger are reported. the enzyme, which has a molecular weight of 323,000, consists of four subunits and is highly resistant to sodium azide.	1978	728844
inhibition of alpha-l-arabinofuranosidase (aspergillus niger) and non-inhibition of alpha-l-arabinopyranosidase (almond emulsin and barley) by l-arabinono-1,4-lactone.		1978	728915
quantitative structure activity correlation of anti-aspergillus niger activity of 4-substituted benzophenones.		1978	733822
toxicity of zinc to fungi, bacteria, and coliphages: influence of chloride ions.	a 10 mm concentration of zn2+ decreased the survival of escherichia coli; enhanced the survival of bacillus cereus; did not significantly affect the survival of pseudomonas aeruginosa, norcardia corallina, and t1, t7, p1, and phi80 coliphages; completely inhibited mycelial growth of rhizoctonia solani; and reduced mycelial growth of fusarium solani, cunninghamella echinulata, aspergillus niger, and trichoderma viride. the toxicity of zinc to the fungi, bacteria, and coliphages was unaffected, le ...	1978	736544
microbiological transformations of flavonoids: part v--transformation of flavone.		1978	738753
role of opportunistic fungi in ocular infections in nigeria.	the importance of opportunistic fungal pathogens in causing ocular infections is emphasized. a study was conducted over a period of 4 years (1974--1977) to investigate the role of opportunistic fungi in causing mycotic keratitis and to elucidate certain aspects of epidemiology of this disease in nigeria. fifty-nine cases of corneal ulcers of suspected mycotic etiology were investigated. fungal etiology was confirmed in 42 of these cases. the predominant etiological agent was fusarium solani in 1 ...	1978	745623
[effect of temperature on production of pectic enzymes with aspergillus niger in fermentators].		1978	753252
[proteo-polysaccharidic turbidity in depectinized raspberry juice].	a revertible turbidity happens in the depectinized red raspberry juice under refrigeration. its analysis is carried out: --chemically: total sugar determination by anthrone methol, galacturonic acid determination by carbazol, total nitrogen determination according to berthelot's coloured reaction (automated analysis) -- physically: calcium, potassium and magnesium determinations by atomic absorption. -- chromatographically: sugar separation and determination by hplc. m. w. determination of the d ...	1978	754586
[treatment of mycoses with corticoid-containing drugs].		1975	765299
the effect of fetal bovine serum on polyene macrolide antibiotic cytotoxicity and antifungal activity.	the relationships between fetal bovine serum (fbs) concentration and polyene macrolide antibiotic cytotoxicity to animal cells and to fungi were evaluated. the toxicity of amphotericin b (ab) and its derivative, amphotericin b methyl ester (ame), toward kb cells was found to be directly related to fetal bovine serum concentration. at higher fbs levels, increased concentrations of ab and ame were required to reduce 72-hr kb viable cell numbers of 50% of control values. similarly, polyene macrolid ...	1976	780260
isolation of ethyl p-methoxycinnamate, the major antifungal principle of curcumba zedoaria.	an antifungal principle of the dried rhizomes of curcuma zedoaria was extracted with hot ethanol. by successive chromatography on neutral alumina and silica gel, three antibiotic compounds a, b, and c, all active against trichophyton rubrum, aspergillus niger and saccharomyces cerevisiae, were obtained in chemically pure form. by uv, ir, pmr and ms analysis, the structure of the most abundant one of these compounds (c, 69.8%; h, 6,8%; and 0.23.4%) was assigned as ethyl p-methoxycinnamate (epmc). ...	1976	785141
antifungal activity of 4-substituted crotonic acid esters.	twenty-three 4-substituted crotonic acid esters were tested for antifungal activity against candida albicans, aspergillus niger, mucor mucedo, and trichophyton mentagrophytes. for the analogues of the methyl ester containing substituents in the 4 position, the following order of fungitoxicity was observed: i greater than br greater than cl greater than ch3s greater than ch3o greater than f=h. of the homologues of the esters of the 4-iodo and 4-bromo compounds which included methyl, ethyl, n-prop ...	1976	787525
incidence of serum antibodies to several aspergillus species and to candida albicans in cystic fibrosis.	the incidence of serum ige antibodies to several species of aspergillus and the incidence of serum precipitins to these species and to candida albicans were determined in 22 children with cystic fibrosis, 17 children with bronchial asthma, and 18 control subjects. ige antibodies were found in 50 per cent of the patients with cystic fibrosis and in 29 per cent of the patients with bronchial asthma; none was found in the control subjects. precipitins to aspergillus species were present in 59 per c ...	1976	788564
phyllosphere microflora of some egyptian plants.	the fungal and bacterial flora of the leaf surfaces of five plants growing in egypt were studied. the fungal flora showed seasonal fluctuations with at least one peak. twenty three genera with fifty three species were found, aspergillus and penicillium being most common. other fungi showed variable percentages of the total count. nitrogen-fixing bacteria were not isolated from the phyllosphere of the five plant species. micrococci were most predominant among the epiphytic bacteria. spore-forming ...	1975	806505
two antimicrobial alkaloids from heartwood of liriodendron tulipifera l.	alcoholic extracts of the heartwood of liriodendron tulipifera have demonstrated antimicrobial activity against staphylococcus aureus, mycobacterium smegmatis, candida albicans, and aspergillus niger. the antimicrobial activity was associated only with the alkaloidal fraction. separation of the active alkaloidal fraction by chromatography led to the isolation and identification of dehydroglaucine and liriodenine as the active components. several other alkaloidal derivatives were prepared and tes ...	1975	807704
synthesis and antibacterial and antifungal activities of 5-nitro-2-furfurylidene polyhalophenoxyacethydrazides viii.	fifteen 5-nitro-2-furfurylidene phenoxyacethydrazides were synthesized, and the antibacterial and antifungal activities of the compounds prepared were determined against different microorganisms. the o-methoxy derivative was found to be the most active compound.	1975	807705
2-phenethylimidazole derivatives. synthesis and antimycotic properties.	compounds of type (x = o, nh; ar and ar' = phenyl of substituted phenyl; ten examples) were prepared and assayed against miconazole (ii,x = o; ar = ar' =2,4-cl2c6h3) as potential antimycotic agents. optimal activity was noted for i(x = o; ar = ar' = 2,4-cl2c6h3), the direct analog of miconazole. it is about one-tenth as active.	1975	807735
antimicrobial activity of alkaloids from amphibian venoms and effects on the ultrastructure of yeast cells.		1975	809864
study of atmospheric fungi in a big cereal silo over a period of one year.	a quantitative and qualitative study of the atmospheric fungi in a big silo was carried out over a period of one year (april 1973--april 1974). about 6 to 12 petri dishes with czapek medium were exposed for 5 minutes every month at different floors of the silo. the study showed:--a very high number of fungi colonies, reaching as many as 903 in march 1974 (a total of 60 min exposure); the dominant fungus was penicillium which was, however, overpassed in certain months by aspergillus (flavus and f ...	1975	810877
amino acid analogs. iii: new syntheses of monomethyl- and monophenylglutamic acids.	glutamic acid analogs containing 3- and 4-methyl and 2-, 3-, and 4-phenyl substituents were prepared. the 3- and 4-methyl- and 3- and 4-phenylglutamic acids did not inhibit plasmodium berghei and were nontoxic to the host (mice) at 640 mg/kg. the five analogs in addition to 2-methlglutamic acid were inactive against lactobacillus casei at 1000 mug/ml in a defined medium: against escherichia coli, only 2-methylglutamic acid caused 27% inhibition at 10,000 mug/ml. all six analogs failed to inhibit ...	1975	811786
adamantanamine derivatives. antimicrobial activities of certain mannich bases.	a series of mannich condensation products containing the beta-(1-adamantylamino)propiophenone skeleton (type i) and the o-(1-adamantylaminomethyl)phenol skeleton (type ii) was synthesized and tested for antimicrobial activity against certain bacteria and fungi by the agar diffusion and tube dilution methods. type i compounds were more active than type ii compounds and had a broad-spectrum effect on certain gram-negative and gram-positive bacteria, acid-fast bacteria, a yeast, and a mold.	1976	812993
hemolytic, cytotoxic and complement inactivating properties of extracts of different species of aspergillus.	some of the biological properties of saline extracts of the mycelia of several species of the aspergillus genus, namely, a. fumigatus, a. flavus, a. niger, a. nidulans, a. parasitucus and a. glaucus, were studied. only the extract prepared from a. fumigatus was found to be hemolytic for sheep red blood cells. in contrast, all the extracts with the only exception of that of a. glaucus, had cytotoxic effects on vero cells. both, the hemolytic and cytotoxic constituents of the extracts were removab ...	1975	813147
degradation of 4-aminopyridine in soil.		1976	818143
quantitative structure-activity relationships. 2. a mixed approach, based on hansch and free-wilson analysis.	based on the theoretical and numerical equivalence of hansch's linear multiple regression model and the modified free-wilson model a mixed approach is developed. the mixed approach is a combination of both models which makes use of the advantages of each model and widens the applicability of hansch and free-wilson analysis. the free-wilson approach now is applicable also in the case of parabolic dependence of biological activity on a particular physical property, e.g., log p or pi. a rational ex ...	1976	818381
formation of ethylenethiourea from 5,6-dihydro-3h-imidazo[2,1-c]-1,2,4-dithiazole-3-thione by microorganisms and reducing agents.	microorganisms formed readily ethylenethiourea (etu) from 5,6-dihydro-3h-imidazo[2,1-c]-1,2,4-dithiazole-3-thione (didt), a spontaneous decomposition product of ethylenebisdithiocarbamates. this conversion also takes place after addition of reducing compounds like cysteine, glutathione or ascorbic acid. it consists of two steps: reduction of the s-s bond of didt with subsequent release of cs2 to form etu. didt was reduced by nadh in the presence of enzyme extracts from pseudomonas fluorescens or ...	1976	819482
allergic bronchopulmonary aspergillosis: a study of 46 cases with special reference to laboratory aspects.	a study of 46 cases of allergic bronchopulmonary aspergillosis has been presented with special reference to laboratory aspects. episodic airways obstruction and dual skin reaction to aspergillin were present in all the cases. furthermore, there were pulmonary infiltrations in 91.1%, blood eosinophilia in 80.4%, precipitins in 91.3%, and sputum cultures repeatedly positive for a. fumigatus in 82.6% of the patients. it was observed that the multiplicity of precipitin bands corresponded to the high ...	1976	821142
[aspergillus serum precipitins in patients of a lung clinic].	the incidence and distribution of aspergillosis among patients of a lung clinic in west berlin were recorded. the immunodiffusion test (idt) was used on sera of 228 patients seen during one day to test for precipitins against a. fumigatus, a. flavus, and a. niger. precipitating antibodies specific against a. fumigatus were found in five patients, in two of them a. fumigatus was isolated simultaneously from sputum. in order to obtain a clear view of the clinical occurrence of asperigillosis and i ...	1976	821738
repressible alkaline phosphatase in aspergillus niger.	alp from a. niger is a) p1 repressible enzyme; b) stimulated by addition of zn++ to the growth medium, and c) that edta inhibits the enzyme reversibly, which could be restored by addition of zn++ and perhaps mg++. this property is in contrast to the enzyme from n. crassa, which is independent of any metal requirement.	1976	821776
colonization of rye green manure and peanut fruit debris by aspergillus falvus and aspergillus niger group in field soils.	aspergillus flavus and aspergillus niger group colonization of deep-plowed, decomposing rye green manure cover crops in peanut field soils was studied in four fields during 1972 and 1973; colonization of decomposing peanut fruits was studied in 1972 in two fields. a. flavus colonization of rye and peanut fruits was greater in soils of heavy texture, and an a. flavus population as high as 165 propagules per g of soil was observed in soil adjacent to rye, whereas a. flavus populations in soils not ...	1976	823865
moisture-equilibrium relative humidity relationships in pistachio nuts with particular regard to control of aflatoxin formation.		1976	825681
[characteristics of the fungal corrosion of some glass ceramic materials].		1976	825702
the role of glycosidically bound mannose in the assimilation of beta-galactosidase by generalized gangliosidosis fibroblasts.		1976	827294
beta-glucosidase: microbial production and effect on enzymatic hydrolysis of cellulose.	the enzymatic conversion of cellulose is catalyzed by a multiple enzyme system. the trichoderma enzyme system has been studied extensively and has insufficient beta-glucosidase (ec 3.2.1.21) activity for the practical saccharification of celluose. the black aspergilli (a. niger and a. phoenicis) were superior producers of beta-glucosidase and a method for production of this enzyme in liquid culture is presented. when trichoderma cellulase preparations are supplemented with beta-glucosidase from ...	1977	837251
purification and properties of a beta-mannosidase from aspergillus niger.	a beta-mannosidase (beta-d-mannoside mannohydrolase, ec 3.2.1.25) was purified to apparent homogeneity from the culture filtrate of the fungus, aspergillus niger. the enzyme had an estimated molecular weight of about 120,000 and was a glycoprotein. radioactive enzyme was prepared by growing the fungus in [14c]fructose, and this enzyme was used for the preparation of 14c-glycopeptides. the glycopeptides were purified on sephadex g-25 and g-50 and were then hydrolyzed for sugar analysis. two radio ...	1977	845158
the isolation and biosynthesis of the ceramide-phosphoinositol of aspergillus niger.		1977	849793
chemical structure of the galactomannan from the cell wall of aspergillus niger.	the galactomannan of surface grown aspergillus niger has been isolated by alkaline extraction of hyphal walls and characterized structurally. its elution profile, from a column of bio-gel p-150, reveals a broad range of molecular sizes grouped into two fractions. gas chromatographic and colorimetric analyses indicate that each fraction is composed of approximately equimolar quantities of galactose and mannose plus 12 to 14% glucose. both have similar low optical rotations and contain acid labile ...	1977	856795
a study on fungal radioresistance and sensitivity.	lower doses of gamma and x-rays (5 and 1 krad, respectively) stimulated the spore germination and growth of 7 tested fungi. higher doses (500 and 100 krad, respectively) revealed that epicoccum nigrum was the most radioresistant, while alternaria humicola, stemphylium verruculosum, rhizopus nigricans, and cladosporium herbarum were of moderate resistance. aspergillus niger and penicillium oxalicum were the most radiosensitive. protein and polysaccharide synthesis were inhibited in the mycelium d ...	1977	857505
a turbidimetric method for the screening of amylase-producing mutants of aspergillus niger.	the method is based on the assumption that extracellular amylase, which is produced by strains of aspergillus niger in liquid culture, hydrolyses the starch in the media and brings about a corresponding decrease in the turbidity of the media. mutant strains which produced different quantities of amylase exhibited different degrees of decrease in turbidity of the media. the results showed that a greater degree of decrease in turbidity was observed for a higher quantity of amylase produced.	1977	858380
[hydroxylation of indolyl-3-acetic acid by the fungus aspergillus niger ibfm-f-12].	physiological and biochemical properties of the culture of aspergillus niger ibpm f 12 carrying out hydroxylation iaa in the 4-, 5-, 6-positions of the indole nucleus were studied. the optimal composition of the medium for the cultivation was established. the transformation was performed by the washed fungal mycelium taken in the middle of the growth log-phase at a substrate concentration of i g/l. the correlation between the hydroxylase activity and ph, temperaure and biomass quantity was shown ...	1977	866301
production and antibacterial activity of malforming c, a toxic metabolite of aspergillus niger.	the production of the new mycotoxin malformin c by a solid substrate fermentation is described. malformin c is highly toxic (mean lethal dose = 0.9 mg/kg) and exerts antibacterial activity against a variety of gram-positive and gram-negative organisms.	1977	869543
coeliac disease: the abolition of gliadin toxicity by enzymes from aspergillus niger.	1. gliadin from which carbohydrate was removed by treatment with carbohydrase from aspergillus niger was fed to three coeliac patients in remission. 2. xylose absorption, mucosal morphology and brush-border enzymes were used to assess the toxicity of the carbohydrase-treated gliadin. 3. gliadin treated with carbohydrases did not damage the intestinal mucosa of the coeliac patients. 4. the primary structure of the gliadin proteins was not altered by the enzyme treatment.	1977	872519
structure-activity studies using valence molecular connectivity.	the extension of the molecular connectivity concept to the treatment of heteroatom molecules affords an opportunity to examine structure-activity relationships in a wide variety of molecule series that possess biological activity. four series are described in this report. the correlations found indicate that molecular connectivity is an extremely useful descriptor of structure in studying drug molecule structure-activity relationships.	1977	874744
[enzyme electrodes--glucose electrodes].		1977	883367
a sensitive estimation of the percentage of guanine plus cytosine in deoxyribonucleic acid by high performance liquid chromatography.		1977	883630
studies on mycobacillin derivatives. iii. reduction of carboxyl groups of the antibiotic.		1977	885799
stereospecific sulfur oxidation of 7-methylthioxanthone-2-carboxylic acid by calonectria decora.	thin-layer chromatography was used to determine the ability of three microorganisms capable of sulfur oxygenation, including aspergillus niger, streptomyces armentosus subsp. armentosus, and calonectria decora, to oxidize 7-methylthioxanthone-2-carboxylic acid to the corresponding sulfoxide in growing cultures. in addition, optical rotary dispersion, circular dichroism, and nuclear magnetic resonance analysis in the presence of chiral shift reagent were used variously to access reaction stereose ...	1977	889328
studies on xylan-degrading enzymes. ii. action pattern of endo-1,4-beta-xylanase from aspergillus niger str. 14 on xylan and xylooligosaccharides.		1977	889848
[studies of the chronic toxicity of mold pectinase].	studied was the action of mould pectinase produced in this country, using asp. niger. rats and guinea pigs were subject to the testing through continuous oral treatment. the preparation was mixed with feed at 0.1 and 0.2 ratio percents (1000 and 2000 ppm)--with the rats for a period of 90 days, and with the guinea pigs--in the course of 180 days. it was found that the enzyme preparation stimulates the growth (more strongly expressed in rats), showing no adverse effect on the appetite and behavio ...	1977	898650
a novel enzymic transfer reaction resulting in the synthesis of 1,6-anhydro-beta-d-glucopyranose.		1977	900955
alteration of thermal stability of glucose oxidase associated with the redox states.		1977	907711
[formation of prototrophic colonies during crossing of deficient mutants of aspergillus niger].	deficient mutants of aspergillus niger were obtained under the action of high doses of mutagens, viz. nitrosomethylurea, ethyleneimine, uv and gamma-rays, and their combinations. if the mutants to be crossed were derived from one and the same strain, prototrophous colonies of heterokaryons grew on a minimal medium, the frequency of their formation being 2-10(-7)-5-10(-7). if the mutants were obtained from different strains, heterokaryons appeared only in 40 per cent of crossings. heterokaryons d ...	1977	909470
high-pressure liquid-chromatographic assay of nucleotide-pool concentrations during polysaccharide biosynthesis in four ascomycetes.	high-resolution liquid-chromatographic methods developed for analyzing nucleotide pools at the nanogram level in four representative species of ascomycetes (penicillium citrinum, aspergillus niger, fusarium moniliforme, and cladosporium herbarum) were used to study polysaccharide biosynthesis. nucleotides extracted from the mycelial mat were preseparated from interfering polysaccharides, glycoproteins, and nucleic acids on a column of biogel p-2. resolution of 18 nucleotides from each fungal spe ...	1977	912696
distribution and conformation of crystalline nigeran in hyphal walls of aspergillus niger and aspergillus awamori.	hyphal walls of aspergillus awamori containing increased amount of the alpha-glucan, nigeran, became correspondingly more opaque when viewed in the electron microscope as shadowed preparations. however, increased polymer deposition was not accompanied by any significant change in wall thickness. the nigeran of both a. awamori and aspergillus niger occurred in situ in a crystalline conformation identical to that of single crystals prepared with pure polysaccharide. furthermore, this polymer was t ...	1977	914782
letter: biotin biosynthesis. 1. the incorporation of specifically tritiated dethiobiotin into biotin.		1976	932356
studies on otitis externa in dogs. i. survey of aetiological agents: fungi.		1976	934187
search for b-1 aflatoxin and similar fluorescent compounds in 'misso'.	following previous studies on the investigation of b-1 aflatoxin in food samples (4,5) we report in this paper the results obtained using thin layer chromatography (tlc) with three different solvent systems and spectrophotometric analysis in order to differentiate actual b-1 aflatoxin and aflatoxin-like substances. twenty 'misso' samples were studied and we could detect aflatoxin in 3 of them. an aflatoxin-suspected substance was also isolated. no aflatoxin-producing aspergillus was isolated fro ...	1976	934259
microbial models of mammalian metabolism: aromatic hydroxylation of isomeric xylenes.	the ability of 11 microorganisms to convert o-, m-, and p-xylene to monophenolic metabolites was evaluated. four organisms were found to produce qualitatively identical products to those observed with mammalian systems.	1976	945717
mineral nutrition of aspergillus niger for citric acid production.	the mineral requirements of a strain of aspergillus niger for the production of citric acid in a synthetic medium were studied. it was observed that k2hpo4 and mgso4. 7 h2o were required at concentrations of 0.1% and 0.02% respectively. the optimum level of each of the trace elements fe, mn and zn was 1.0 mug/ml. nac1 and cac12 at lower concentrations had no effect on citric acid production. trace elements, cu, co and mo, had an adverse effect on the production of citric acid while ni and v were ...	1976	947831
measurement of glucose in plasma, with use of immobilized glucose oxidase and peroxidase.	we describe a novel fluorometric technique for simple, rapid, and economical assay of glucose by use of immobilized glucose oxidase and peroxidase. a cylindrical magnetic stirrer was specially designed to hold the immobilized enzymes firmly and to allow the reaction minzymic transformation quickly. blood plasma can be assayed directly with no pretreatment. ascrobic acid, uric acid, and creatinine in concenctrations of 0.25, 0.25, and 0.2 g/liter, respectively, did not interfere. the linearity of ...	1976	949848
[mycoses of hop nematode (heterodera humuli filipjev, 1934) cysts].		1976	950925
synthesis and antibacterial and antifungal activities of alkyl and polyhalophenyl esters of benzo[b]-3-methyl-2-furancarbamic acid.	several alkyl and polyhalophenyl esters of benzo[b]-3-methyl-2-furancarbamic acid were prepared and tested for antifungal activity against candida albicans, penicillium notatum, and aspergillus niger. the pentachlorophenyl ester was the most active substance and the only compound to show antibacterial activity against staphylococcus aureus.	1976	957121
circular dichroism study of bovine plasma amine oxidase, a cu-amine oxidase.		1976	961541
the citric acid fermentation by aspergillus niger: regulation by zinc of growth and acidogenesis.	the citric acid fermentation by aspergillus niger is divided into two consecutive phases, a growth phase when the cells proliferate but do not accumulate citrate, followed by an accumulating phase when they produce citrate but do not proliferate, or else do so at a much reduced rate. when studied in a low sucrose (0.4-0.8%) mpinimal salts medium the growth-accumulation alternative was controlled by the concentration of zinc: high zinc (about 1-2 mum) maintained growth phase, while at low zinc (b ...	1976	963622
isolation, properties, and crystallization of an iron-chlorin protein from aspergillus niger.	a green iron-chlorin protein was purified 160-fold from a lyophilized extract of aspergillus niger by ion-exchange chromatography and gel filtration with a yield of 25%. the purified preparation appeared nearly homogeneous on sedimentation analysis and the sedimentation coefficient of the protein at infinite dilution was 13.4s. its molecular weight was calculated to be 2.8--3.2 x 10(5) from sedimentation and gel filtration data. the ferric form of the protein had absorption maxima at 587.5 and 7 ...	1976	977555
activation of the alternative complement pathway by water-insoluble glucans of streptococcus mutans: the relation between their chemical structures and activating potencies.	water insoluble, sticky glucan was synthesized by reacting glucosyltransferase obtained from the sulture filtrate of cariogenic streptococcus mutans omz 176 on sucrose. this glucan (omz 176 glucan), that consisted of the backbone chains of consecutive alpha-1, 3 glucosidic linkages (65%) and the side chain of alpha-1, 6 glucosidic bonds (35%), showed an ability to activate the alternative pathway of the complment system in human serum. water soluble glucans synthesized from the reaction of glyco ...	1976	977950
stepwise mutational improvement of aspergillus niger for citric acid productivity in cane molasses.		1976	983723
tolciclate against dermatophytes.	0-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl)-m-n-dimethylthiocarbanilate (toliciclate; kc 9147) is a new topical antimycotic having an in vitro activity on dermatophytes between 0.1 and 0.01 mug/ml. it is fungicidal after some day's contact. it has the advantage over dyes used in the past for topical treatment of dermatomycoses in that it is colourless and is soluble in well tolerated excipients. it is more liposoluble than tolnaftate. in the guineapig skin infections with trichophyton aste ...	1976	989349
studies on some nutritional factors influencing the production of gluconic acid.	investigations were carried out to formulate an economical medium that can give maximum yield of gluconic acid by the submerged culture technique, using aspergillus niger nrrl3. it was found that the highest yield of acid could be secured when a medium of the following ingredients was used: 13.0% glucose syrup, 0.1% nano3, 0.025% calcium superphosphate, 0.007% kcl, 0.025% mgso4-7h20, and 0.5% caco3. it was also found that glucose syrup, which represents an available and cheap carbohydrate source ...	1976	989655
immobilization of enzymes based on hydrophobic interaction. ii. preparation and properties of an amyloglucosidase adsorbate.	amyloglucosidase from aspergillus niger (alpha-1,4 and 1,6 glucan glucohydrolase, ec 3.2.1.3) was immobilized through adsorption onto a hexyl-sepharose, containing 0.51 mol hexyl-group per mole of galactose. the adsporption limit of the carrier with respect to this enzyme was about 17 mg per gram wet conjugate. the retention of activity upon immobilization was high, varying from essentially full activity at low enzyme content down to 68% at the adsorption limit. the immobilized preparation, as w ...	1976	990428
microbial metabolism of n-methylcarbamate insecticide. i. metabolism of 0-sec-butylphenyl n-methylcarbamate by aspergillus niger van tieghem.		1976	991352
microbial metabolism of n-methylcarbamate insecticide. ii. synthesis of metabolites of o-sec-butylphenyl n-methylcarbamate.		1976	991353
microbial metabolism of n-methylcarbamate insecticide. iii. time course in metabolism of o-sec-butylphenyl n-methylcarbamate by aspergillus niger and species differences among soil fungi.		1976	991354
isolation and characterization of inositol-containing glycosphingolipids from aspergillus niger.		1976	1001787
purification and characterisation of polygalacturonases from a commercial aspergillus niger preparation.	the polygalacturonase (poly(1,4-alpha-d-galacturonide) glycanohydrolase, ec 3.2.1.15) activity of pectinol is resolved into two fractions (e1 and e2) of about equal total activity on deae-cellulose. these fractions are purified from other pectinolytic enzyme activity by sephadex g-75 chromatography. both e1 and e2 reduce the viscosity of polygalacturonate by 50% after 7% of the glycosidic bonds are hydrolysed. their activities are not affected by iodoacetate (1 mm) or edta (10 mm). e1 and e2 hav ...	1976	1009121
[stimulation of conidial sprouting by aspergillus niger--a citric acid producer under the influence of mutagenic factors].		1976	1013315
glycoprotein nature of tannase in aspergillus niger.	1. tannase (tannin acyl-hydrolase, ec 3.1.1.20) was isolated from the culture medium of aspergillus niger and purified about 200-fold. on polyacrylamide-gel electrophoresis it gave a single band. 2. the molecular weight of the enzyme was of the order of 55 000 as determined by gel filtration. the enzyme contains 21.5% of carbohydrates (mannose and glucose). 3. treatment of tannase with alkaline borohydride decreased the content of threonine, serine and mannose, suggesting that the carbohydrate-p ...	1976	1015151
[pharmacocinetic behaviour of alpha-l-arabinofuranosidase in therapeutical application to toxify transport forms of cancerostatic substances (author's transl)].	the present studies were carried out to obtain pharmacokinetic data about the elemination of intravenously administered alpha-larabinofuranosidase from the blood stream and about the distribution and retention of the enzyme in different organs and in a transplantable sarcoma of mouse. the results were used for the planning of therapeutical experiments, in which detoxified transport forms of cancerostatic agents were to be toxified by exogenous enzymes specifically in the tumour tissue. the alpha ...	1976	1021009
light stimulated 'shunt-metabolism' succinate-alpha-ketoglutarate-isocitrate cycle and accumulation of citric acid in aspergillus niger.	studies with light of the visible range had shown that light plays significant role in the biosynthesis and accumulation of citric acid in aspergillus niger. accumulation of 14c-labelled carbon atoms in alpha-ketoglutaric, isocitric, succinic and glycolic acids in the cultures grown under illumination suggest a probable 'shunt-metabolism' leading to the succinate-alpha-ketoglutarate-isocitrate (ski) cycle. this shunt metabolism minimizes the accumulation of citric acid in cultures due to depleti ...	1976	1021433
[changes in pectolytic activity with aspergillus niger incubated at various temperatures].		1976	1024559
[the blastomycete flora of the external ear in humans].		1976	1027461
purification of aspergillus niger alpha-amylase.		1976	1037047
possible role of solar radiation on the viability of some air fungi in egypt.	the high occurrence of alternaria humicola and the moderate occurrence of stemphylium verruculosum, rhizopus nigricans, and epicoccum nigrum in the air of egypt could be correlated to their apparent resistance to solar radiation. cladosporium herbarum, aspergillus niger, and penicillium oxalicum, although highly occurring, were light-sensitive. the miniumum solar radiation in november, coupled with the highest total fungal catch, dominated by cladosporium herbarum, reveals the importance of sola ...	1976	1037050
successful control of systemic aspergillus niger infections in two patients with acute leukemia.	the diagnosis and successful control of systemic aspergillus niger infection in 2 adult patients with acute leukemia is reported. during induction therapy, the first patient developed pulmonary infiltrates, skin lesions and abnormal liver function tests. aspergillus niger was found on skin and liver biopsy. this patient was successfully treated with amphotericin b and granulocyte transfusions and he remains in remission. the second patient developed a pneumonitis and adynamic ileus with positive ...	1975	1060508
pharmacological investigations of virosecurinine.	this study reports some biological studies on the alkaloid virosecurinine isolated from the plant securinega virosa. virosecurinine is an isomer of the securinine group of alkaloids present in plants used in traditional medicines in many areas, including the central district of papua new guinea. virosecurinine is mildly toxic to mice with an ld50 of 73 milligrams per kilogram body weight. death results from violent tonic convulsions and paralysis similar to those observed with strychnine poisoni ...	1976	1065158
formation of protoplasts from ustilago maydis.	protoplasts of ustilago maydis were obtained by incubating sporidia of the fungus with a combination of helicase and a commercial "onozuka" r-10 enzyme preparation of trichoderma harzianum in the presence of 0.6 m (nh4)2 so4 as an osmotic stabilizer. in the presence of the organic stabilizers sorbitol and sucrose, however, the release of protoplasts was inhibited. combinations of helicase with other lytic enzymes such as cellulase from aspergillus niger, cellulase and hemicellulase from rhizopus ...	1976	1086637
pimaricin and mycostatin for retarding cottage cheese spoilage.	two antifungal agents, pimaricin and mycostatin, added to cottage cheese through the wash water at concentrations of 20, 50, or 100 mug/ml of wash water or added through the cheese dressing at 1, 2, or 5 mug/g retarded the growth of aspergillus niger and saccharomyces cerevisiae and improved the shelf-life of the cheese. in general, cheese with highest concentration of antifungal agent and stored at lowest temperature had best keeping quality. pimaricin was slightly more effective than mycostati ...	1975	1095618
[aspergillus infection in skin transplantation and its therapy].	in a 10 years old girl sustaining a corrosive injury of the lower leg from sulphuric acid, in the region of a skin transplantation colonization with aspergillus fumigatus (fresenium) and aspergillus niger (van tieghem) took place. this infection endangered the attempt of transplantation and the saving of the foot. treatment by medication with nystatin (moronal) and canesten (clotrimazol) were ineffective. pimaricin (pimafucin, natamycin) quickly erradicated the mycotic infection and secured an u ...	1975	1102271
antimicrobial effect of simple lipids with different branches at the methyl end group.	various fatty acids of branched nature possess fungistatic and bacteriostatic properties. some of these, particularly those of iso-configuration, strongly enhance the effect of conventional antimicrobial agents that act inside the cell membrane. a relation between this biological effect and the collapse properties of the corresponding monomolecular surface film on water has been observed. in this work, a series of fatty acids with a slightly smaller end group than iso-propyl, the omega-cycloprop ...	1975	1108782
protein content and amino acid composition of certain fungi evaluated for microbial protein production.	the protein and total amino acid contents of four mycelial fungal strains and one yeast were approximately the same for cultures harvested in the mid-log and early stationary growth phases. it was found that fusarium oxysporum and fusarium moniliforme contained approximately 30% more protein and total amino acids than aspergillus niger. the amino acid composition of mycelial protein compares favorably with that of british petroleum yeast protein toprina produced commercially on hydrocarbon subst ...	1975	1115498
influence of the extract of chlorella vulgaris on growth of fungi.		1975	1121933
[effect of cyclic compounds on pigment formation in aspergillus niger cultures].	the mycelial pigment os asp. niger vp has been fractionated into four fractions ehose solubility is similar to melanin pigments obtained from other sources. the addition of pyrocatechol, l-aspartic, benzoic, kojic and salicylic acids to the liquid capek medium stimulates the fungal growth but diminishes the yield of fractions of the melanin pigment from the mycelium. cinnamic acid does not influence the growth but also decreases the yield of the pigment. dl-tyrosine stimulates the fungal grow ...	1975	1129232
[application of the theory of oxygen transfer: determination of the michaelis constant of glucose oxidase with respect to oxygen].	the oxidation of beta-d-glucose with glucose oxidase generally requires oxygen, which, under normal conditions is present at low concentrations in the reaction medium. experiments show that glucose oxidase is no longer saturated by oxygen at enzyme concentrations greater than 0.4 mg.ml1. this is due to the decrease in the oxygen concentration of the solution. the value of the oxygen mass transfer coefficients and dissolved oxygen concentrations are determined. these dissolved oxygen concentratio ...	1975	1138970
toxigenic fungi in food.	forty-five fungal isolates from moldy supermarket foods were tested for toxicity to brine shrimp, and twenty-two of these isolates were subsequently tested for toxicity to chicken embryos. highly toxigenic fungi were cladosporium sphaerospermum from a bakery product, fusarium oxysporum from carrots, f. solani from cabbage, aspergillus niger and penicillium corylophilum from bread, p. cyclopium and p. herguei from corn meal, p. lanosum from onions,p. steckii from chocolate syrup, penicillium sp. ...	1975	1147614
biosynthesis of flaviolin and 5,8-dihydroxy-2,7-dimethoxy-1,4-naphthoquinone.	tracer experiments indicate a polyketide origin for the production of flaviolin (2,5,7-trihydroxy-1,4-naphthoquinone) by aspergillus niger and 2,7-dimethoxynaphthazarin (5,8-dihydroxy-2,7-dimethoxy-1,4-naphthoquinone) by streptomyces no. 12396. with the streptomycete, a "solid state fermentation" technology was used for the incorporation studies. radioactivity from shikimic acid was effectively incorporated into flaviolin; this conversion, however, proceeded by way of acetic acid. the latter sta ...	1975	1148193
the occurrence in nature of a diploid strain of aspergillus niger.		1975	1151341
oxalate accumulation from citrate by aspergillus niger. i. biosynthesis of oxalate from its ultimate precursor.	carbon-14 was incorporated from citrate-1,5-14c, glyoxylate-14c(u), or glyoxylate-1-14c into oxalate by cultures of aspergillus niger pregrown on a medium with glucose as the sole source of carbon. glyoxylate-14c(u) was superior to glyoxylate-1-14c and citrate-1,5-14c as a source of incorporation. by addition of a great amount of citrate the accumulation of oxalate was accelerated and its maximum yield increased. in a cell-free extract from mycelium forming oxalate from citrate the enzyme oxaloa ...	1975	1156092
oxalate accumulation from citrate by aspergillus niger. ii. involvement of the tricarboxylic acid cyclase.	carbon-14 was incorporated into oxalate and co2 from either citrate-1,5-14c, succinate-1,4-14c, or fumarate-1,4-14c by cultures of aspergillus niger pregrown on a medium which contained glucose as the sole carbon source and which did not allow citrate accumulation. in cell-free extracts of mycelium forming oxalate and co2 from added citrate the following enzymes of the tricarboxylic acid (tca) cycle were identified: citrate synthase ce 4.1.3.7), aconitate hydratase (ec4.2.1.3), nad and nadp-depe ...	1975	1156100
pulmonary oxalosis in association with aspergillus niger infection in a great horned owl (bubo virginianus).		1975	1156263
the occurrence of a phosphorylated glycosphingolipid in aspergillus niger.	a novel type of water-soluble phosphorylated glycosphingolipid was isolated from aspergillus niger by a simple procedure involving precipitation, deae-cellulose chromatography and preparative t.l.c. besides ceramide and phosphorus it contains inositol, galactose, mannose and small amounts of glucosamine.	1975	1156383