Publications

physicochemical properties and in vitro antioxidant activities of polysaccharide from artocarpus heterophyllus lam. pulp.	a water-soluble polysaccharide from artocarpus heterophyllus lam. (jackfruit) pulp (jfp-ps) was purified and its physicochemical properties were investigated. the in vitro antioxidant activities of jfp-ps was evaluated by measuring dpph and oh radicals scavenging activities, as well as reducing power. the results showed that jfp-ps contained 79.12% of total sugar, 5.83% of protein, 15.65% of uronic acid, and 15 kinds of amino acids with high levels of asp, glu, val, leu and lys. jfp-ps was mainl ...	2017	27702522
ultrasound assisted extraction of pectin from waste artocarpus heterophyllus fruit peel.	four factors three level face centered central composite response surface design was employed in this study to investigate and optimize the effect of process variables (liquid-solid (ls) ratio (10:1-20:1ml/g), ph (1-2), sonication time (15-30min) and extraction temperature (50-70°c)) on the maximum extraction yield of pectin from waste artocarpus heterophyllus (jackfruit) peel by ultrasound assisted extraction method. numerical optimization method was adapted in this study and the following opti ...	2017	27773278
inhibition of hepatocarcinogenesis by artinm via anti-proliferative and pro-apoptotic mechanisms.	artinm is a d-mannose-binding lectin found in the seeds of artocarpus heterophyllus (jackfruit) that interacts with n-glycans, that is associated with receptors on the surface of phagocytic cells and induces the production of inflammatory mediators. some of them are especially important because they may be required for antitumor immune response. this study aimed to evaluate the effect of artinm on hepatocellular preneoplastic foci. wistar rats received 50 mg/kg of diethyl-nitrosamine (den) intra ...	2016	27815471
isolation, characterization and the potential use of starch from jackfruit seed wastes as a coagulant aid for treatment of turbid water.	fruit wastes constituting up to half of total fruit weight represent a large pool of untapped resources for isolation of starch with diverse applications. in this work, the possibility of isolating starch from tropical fruit wastes and its extended application as a natural coagulant was elucidated. amongst the 12 various parts of fruit wastes selected, only jackfruit seeds contained more than 50% of total starch content. using alkaline extraction procedures, starch has been successfully isolated ...	2017	27838910
characterization of natural polymers from jackfruit pulp, calendula flowers and tara seeds as mucoadhesive and controlled release components in buccal tablets.	identification and physiochemical parameters such as solubility, loss on drying, viscosity, ph, swelling index, starch and gum constituents were determined in natural polymers and showed satisfactory results. spectral studies established the compatibility of natural polymers. the drug release kinetics in preliminary trial batches showed that tablets containing natural mucilages and gum showed a prolonged drug release comparable to carbopol 974p and methocel k4m. also, all tablets showed a satisf ...	2017	27889336
lectins from synadenium carinatum (scll) and artocarpus heterophyllus (artinm) are able to induce beneficial immunomodulatory effects in a murine model for treatment of toxoplasma gondii infection.	infection by toxoplasma gondii affects around one-third of world population and the treatment for patients presenting toxoplasmosis clinically manifested disease is mainly based by a combination of sulfadiazine, pyrimethamine, and folinic acid. however, this therapeutic protocol is significantly toxic, causing relevant dose-related bone marrow damage. thus, it is necessary to improve new approaches to investigate the usefulness of more effective and non-toxic agents for treatment of patients wit ...	2016	27933277
optimization of postharvest conditions to produce chocolate aroma from jackfruit seeds.	jackfruit seeds are an underutilized waste in many tropical countries. this work demonstrates the potential of roasted jackfruit seeds to develop chocolate aroma. twenty-seven different roasted jackfruit seed flours were produced from local jackfruit by acidifying or fermenting the seeds prior to drying and then roasting under different time/temperature combinations. the chocolate aroma of groups of four flours were ranked by a sensory panel (n = 162), and response surface methodology was used t ...	2017	28110526
sub-micellar concentration of sodium dodecyl sulphate prevents thermal denaturation induced aggregation of plant lectin, jacalin.	the irreversible thermal unfolding of jacalin, the lectin purified from jackfruit seeds was accompanied by aggregation, where intermolecular interactions among the subunits are favoured over intramolecular interactions. the extent of aggregation increased as a function of temperature, time and protein concentration. the anionic surfactant, sodium dodecyl sulphate (sds) significantly suppressed the formation of aggregates as observed by turbidity measurements and rayleigh scattering assay. moreov ...	2017	28133706
flavonoids from the roots of artocarpus heterophyllus.	four new flavonoids, artoheteroids a-d (1-4), together with six known ones (5-10), were isolated from the roots of artocarpus heterophyllus. their structures were elucidated by spectroscopic methods, including 1d and 2d nmr, uv, ir, cd, and hr-esi-ms. all isolated compounds were screened for their inhibitory abilities against cathepsin k (catk). among them, compounds 1-2, 4-6, and 10 were found to have suppression capabilities against catk with ic50 values ranging from 1.4 to 93.9μm.	2017	28163073
design of macroscopically ordered liquid crystalline hydrogel columns knitted with nanosilver for topical applications.	the design of liquid crystalline hydrogels knitted with silver nanoparticles in macroscopic ordering is becoming a subject of research interest due to their promising multifunctional applications in biomedical and optoelectronic applications. the present work describes the development of liquid crystalline schiff-based hydrogel decorated with silver nanoparticles and the demonstration of its antifungal applications. schiff base was prepared from polyglucanaldehyde and chitosan, and the former wa ...	2017	28221765
nutritional composition of fruits selected by long-tailed macaques (macaca fascicularis) in kuala selangor, malaysia.	proximate analysis of twelve species of fruits commonly consumed by long-tailed macaques (macaca fascicularis), i.e., arenga pinnata, areca catechu, terminalia catappa, elaeis guineensis, lagerstroemia tomentosa, mangifera indica, cascabela thevetia, muntingia calabura, musa sp., artocarpus heterophyllus, ficus tinctoria ssp. gibbosa and ficus microcarpa, was conducted with the specific objective to determine the nutritional composition of the foodstuffs of long-tailed macaques. the results show ...	2017	28228918
production of spray-dried honey jackfruit (artocarpus heterophyllus) powder from enzymatic liquefied puree.	this paper presents the enzymatic liquefaction process for honey jackfruit optimized with pectinex(®) ultra sp-l and celluclast(®) 1.5 l individually or in combinations at different concentrations (0-2.5% v/w) and incubation time (0-2.5 h). treatment with combinations of enzymes showed a greater effect in the reduction of viscosity (83.9-98.8%) as compared to single enzyme treatment (64.8-87.3%). the best parameter for enzymatic liquefaction was obtained with 1.0% (v/w) pectinex(®) ultra sp-l an ...	2017	28242955
chemoprevention of colorectal cancer by artocarpin, a dietary phytochemical from artocarpus heterophyllus.	artocarpus heterophyllus is an evergreen tree distributed in tropical regions, and its fruit (jackfruit) is well-known as the world's largest tree-borne fruit. although a. heterophyllus has been widely used in folk medicines against inflammation, its potential in cancer chemoprevention remains unclear. herein we identified artocarpin from a. heterophyllus as a promising colorectal cancer chemopreventive agent by targeting akt kinase. phenotypically, artocarpin exhibited selective cytotoxicity ag ...	2017	28391699