Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| hypersomnia in whipple disease: case report. | whipple disease (wd) is a rare systemic infection caused by tropheryma whippelii. neurological involvement has been recognised in 40% of patients, either as initial manifestations or during the course of the disease. we report on a 45 years-old man with wd with initial, persistent and irresistible episodes of daytime somnolence. the patient was hla-dqb1*0602 positive (genetic marker for narcolepsy). wd diagnosis was suspected on clinical and mri basis and confirmed by histological and immunohist ... | 2006 | 17057900 |
| current concepts of immunopathogenesis, diagnosis and therapy in whipple's disease. | whipple's disease (wd) is a rare chronic infectious disorder caused by the rod- shaped bacterium tropheryma whipplei. the disorder is characterized clinically by arthralgia, abdominal pain, diarrhea, malabsorbtion and progressive weight loss. other important sites of infection include the heart (resulting in the clinical picture of endocarditis and heart failure) and the central nervous system (cns) (manifestations include confusion, memory loss, focal cranial nerve signs, nystagmus and ophtalmo ... | 2006 | 17073638 |
| [scurvy and acquired ichthyosis associated to whipple's disease]. | the skin manifestations, except for hyperpigmentation, are uncommon in whipple's disease (wd). we present the case of a 48-year-old male with chronic diarrhea and long course general syndrome associated to neurological manifestations. skin examination revealed lesions in the lower limbs and gums that were clinically consistent with scurvy and were confirmed by histological study and measurement of blood vitamin c levels. furthermore, he had lesions that were clinically and histologically consist ... | 2006 | 17173764 |
| [whipple's disease]. | whipple's disease is a rare infectious disorder affecting mostly middle aged men. the causative organism, tropheryma whipplei, recently has been cultivated and phylogenetically identified as an actinomycete. the rareness of the disease despite the ubiquitous occurence of t. whipplei presumably is related to a predisposing defect in cellular immunity. the diagnosis usually can be established by small bowel biopsy, but is frequently delayed due to protean clinical manifestations. the initiation of ... | 2007 | 17256556 |
| tropheryma whipplei in the environment: survey of sewage plant influxes and sewage plant workers. | we studied the prevalence of tropheryma whipplei in influxes to 46 sewage treatment plants and in stool, mouthwash fluids, and dental plaques of 64 healthy workers in those facilities and 146 disease control patients. t. whipplei was found in sewage water, in stool of healthy individuals, and significantly more often in stool of workers exposed to sewage water. | 2007 | 17277223 |
| molecular basis of tropheryma whipplei doxycycline susceptibility examined by transcriptional profiling. | tropheryma whipplei is a poorly studied bacterium responsible for whipple's disease. in this study, its susceptibility to doxycycline was investigated at a transcriptional level using a whole-genome dna microarray. | 2007 | 17289769 |
| a patient with cerebral whipple disease with gastric involvement but no gastrointestinal symptoms: a consequence of local protective immunity? | whipple disease is a granulomatous infectious disease caused by tropheryma whipplei. the bacteria accumulate within macrophages, preferentially in the intestinal mucosa. disease manifestation seems to be linked to immunological abnormalities of macrophages. we describe a patient with cerebral whipple disease who presented with changes in mental status, confusion, inverse sleep-wake cycle, bilateral ptosis and vertical gaze palsy. endoscopic biopsy sampling revealed whipple disease in the gastric ... | 2007 | 17371903 |
| eosinophilic vasculitis: a rare presentation of whipple's disease. | whipple's disease is a multisystem infectious disease caused by the bacterium tropheryma whippelii. a case with an unusual presentation is reported. a 66-year-old man presented with a febrile vasculitic rash on his forearms. an extensive rheumatological, hematological and infectious workup gave negative results, apart from mild anemia and eosinophilia. an abdominal computed tomography revealed a retroperitoneal lymphadenopathy, and a skin biopsy revealed an eosinophilic vasculitis. this diverted ... | 2007 | 17377649 |
| tropheryma whipplei infective endocarditis as the only manifestation of whipple's disease. | here we describe a case of infective endocarditis caused by tropheryma whipplei in a patient with no other symptoms of whipple's disease. the case was diagnosed using broad-range pcr and confirmed by specific pcrs. we review the cases of infective endocarditis presenting as the only manifestation of whipple's disease reported in the literature. | 2007 | 17446327 |
| cultivation of tropheryma whipplei from the synovial fluid in whipple's arthritis. | this report describes a patient who presented with fever, weight loss, diarrhea, and adenopathy. at the time of presentation he had a 28-year history of unusually severe destructive polyarthritis. duodenal biopsy revealed periodic acid-schiff-positive macrophages. polymerase chain reaction studies showed positivity for tropheryma whipplei in synovial fluid, synovial tissue, and lymph node specimens, and whipple's disease was diagnosed. t whipplei was successfully cultivated from the synovial flu ... | 2007 | 17469186 |
| [refractory intermediate uveitis in the presence of unexplained joint disease. diagnosis: tropheryma whipplei (morbus whipple)]. | 2008 | 17522867 | |
| false positive pcr detection of tropheryma whipplei in the saliva of healthy people. | tropheryma whipplei, the agent of whipple's disease (wd), has been recently isolated and the genomes of two isolates have been fully sequenced. previous diagnosis tools for the diagnosis of the disease used sequence analysis of the 16s rrna gene. using this target gene, the high percentage of detection of the bacterium in saliva of healthy people was in contrast to the negative results obtained with specific target genes. the aim of our study was to compare previously published primers targeting ... | 2007 | 17535423 |
| increased levels of circulating il-16 and apoptosis markers are related to the activity of whipple's disease. | whipple's disease (wd) is an infectious disease caused by tropheryma whipplei, which replicates in macrophages and induces the release of interleukin (il)-16, a substrate of caspase 3, and macrophage apoptosis. the disease is characterized by intestinal, cardiac or neurological manifestations; its diagnosis is based on invasive analysis requiring tissue biopsies or cerebrospinal fluid puncture. the disease progression is slow and often complicated by relapses despite empirical antibiotic treatme ... | 2007 | 17551575 |
| [whipple's disease: current problems]. | whipple's disease is a rare multisystemic infectious disease of bacterial origin characterized by variable clinical manifestations, and an insidious and chronic relapsing course. untreated disease can be even fatal. the presence of the characteristic (though not specific) triad of weight loss, chronic diarrhea and arthralgias may raise its suspicion. when chronic intermittent fever and lymphadenopathy are associated, the suspicion is substantial. recognition of the causative agent, tropheryma wh ... | 2007 | 17588856 |
| ultrastructural evidence of tropheryma whippelii in pas-negative granulomatous lymph nodes. | the presence of tropheryma whippelii was demonstrated in the pas-negative mesenteric granulomatous lymph nodes of a patient affected by whipple disease. ultrastructurally a few bacteria, enclosed by a membrane characteristic of tropheryma whippelii, were found in the extracellular spaces and remnants of bacteria were found in the phagocytic vacuoles of macrophages. the scarce number of bacilli, probably due to the fact that the disease was at an initial phase, could explain the absence of pas po ... | 2007 | 17613996 |
| therapy for whipple's disease. | whipple's disease was first described in 1907, the genomic composition of the causative organism, tropheryma whipplei, was unravelled in 2003 and its in vitro susceptibility to antibiotics started to be explored in 2004-05. still today, this knowledge is not fully applied in the recommendations for the therapy of this disease. in this paper, we summarize the current recommendations on antimicrobial therapy for whipple's disease and propose a shift in the maintenance therapy. | 2007 | 17623695 |
| recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century. | chloroquine (cq) and its hydroxyl analogue hydroxychloroquine (hcq) are weak bases with a half-century long use as antimalarial agents. apart from this antimalarial activity, cq and hcq have gained interest in the field of other infectious diseases. one of the most interesting mechanisms of action is that cq leads to alkalinisation of acid vesicles that inhibit the growth of several intracellular bacteria and fungi. the proof of concept of this effect was first used to restore intracellular ph a ... | 2007 | 17629679 |
| molecular diagnosis of infective endocarditis by real-time broad-range polymerase chain reaction (pcr) and sequencing directly from heart valve tissue. | traditionally, infective endocarditis (ie) has been microbiologically diagnosed by blood cultures or serology. however, conventional microbiologic methods do not always provide an etiologic diagnosis. we conducted the current study to evaluate the usefulness of a universal real-time polymerase chain reaction (pcr) of the 16s rrna gene followed by sequencing for the diagnosis of ie in explanted heart valve tissue (hv) as part of the routine of a clinical microbiology laboratory, and to compare it ... | 2007 | 17632260 |
| [tonsillar hypertrophy and mesenteric adenopathies as the main manifestations in a patient with whipple's disease]. | whipple's disease is an infrequent chronic infection caused by tropheryma whipplei, identified in 1992. intestinal, articular, central nervous system and cardiac involvement is common. the presence of abdominal adenopathies, especially mesenteric adenopathies, without peripheral adenopathies or gastrointestinal, articular, neurological or cardiac symptoms is rare. we present the case of a male patient with tonsillar hypertrophy, mesenteric adenopathies, fever and constitutional syndrome, leading ... | 2007 | 17692197 |
| whipple disease revealed by musculocutaneous symptoms, with muscle biopsy cultures positive for tropheryma whipplei. | a patient experienced sudden onset of musculocutaneous symptoms 3 years after being diagnosed with polyarthritis. biopsies from the duodenum, skin, and muscle established the diagnosis of whipple disease. cultures of muscle biopsy specimens grew tropheryma whipplei. adequate antibiotic therapy ensured a favorable outcome. to our knowledge, this is the first case in which t. whipplei was recovered from muscle biopsy specimens, confirming the infectious nature of muscle involvement in whipple dise ... | 2007 | 17900961 |
| comparative genomic analysis of tropheryma whipplei strains reveals that diversity among clinical isolates is mainly related to the wisp proteins. | the aim of this study was to analyze the genomic diversity of several tropheryma whipplei strains by microarray-based comparative genomic hybridization. fifteen clinical isolates originating from biopsy samples recovered from different countries were compared with the t. whipplei twist strain. for each isolate, the genes were defined as either present or absent/divergent using the gack analysis software. genomic changes were then further characterized by pcr and sequencing. | 2007 | 17910761 |
| [whipple's disease]. | for many years, whipple's disease was considered a rare, mainly intestinal disease causing malabsorption. at present, however, it appears to be multivisceral mainly occuring in subjects with specific and subtle cell-mediated immunity defects. until recently, diagnosis and follow-up of treatment efficacy depended on pas positive macrophage inclusions in duodenal biopsies. new diagnostic methods based on pcr gene amplification and immunohistochemistry are now available by dna sequencing and cultur ... | 2007 | 17925777 |
| [aortic and mitral valve infective endocarditis caused by tropheryma whipplei and with no gastrointestinal manifestations of whipple's disease]. | a case of blood culture-negative aortic and mitral valve infective endocarditis caused by the bacterium tropheryma whipplei is reported. a 33-year-old man showed no clinical manifestations of whipple's disease, with the exception of arthralgia as given in his history. the disease was complicated by recurrent cerebral and left upper limb embolization of vegetations. the causative agent was detected in a valve sample using broad-range polymerase chain reaction. the patient underwent successful sur ... | 2007 | 17987571 |
| orbital manifestation of whipple's disease: an atypical case. | whipple's disease is a systemic disorder caused by an infection with a gram-positive bacillus, tropheryma whipplei. almost every organ system can be affected in whipple's disease, resulting in varying clinical symptoms. | 2007 | 18029189 |
| advances in tropheryma whipplei research: the rush to find biomarkers for whipple's disease. | whipple's disease (wd) is a systemic chronic infection, caused by the gram-positive bacterium tropheryma whipplei. there are several clinical traits linked to wd: histological lesions in the gi tract in association with diverse clinical manifestations (classic wd), endocarditis with negative blood cultures, and isolated neurological infection. wd is rare, predominantly affects middle-aged men and is fatal without treatment. the most recent strategy for diagnosing wd uses the results of diastase- ... | 2007 | 18041904 |
| molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. | culture of bronchoalveolar lavage fluid (balf) is the gold standard for detection of pathogens in the lower airways in cystic fibrosis (cf). however, current culture results do not explain all clinical observations in cf, including negative culture results during pulmonary exacerbation and inflammation in the absence of pathogens. we hypothesize that organisms not routinely identified by culture occur in the cf airway and may contribute to disease. to test this hypothesis we used a culture-indep ... | 2007 | 18077362 |
| premature ovarian failure in suspected whipple's disease. | whipple's disease is a relapsing systemic infectious disease probably caused by the gram-positive bacillus tropheryma whippelii. the diagnosis can be established based on the characteristic histopathological features found in the affected organ (foamy macrophages with a coarsely granular cytoplasm, which stains with pas, and by means of polymerase chain reaction (pcr) technology). | 2007 | 18078849 |
| genotyping reveals a wide heterogeneity of tropheryma whipplei. | tropheryma whipplei, the causative agent of whipple's disease, is associated with various clinical manifestations as well as an asymptomatic carrier status, and it exhibits genetic heterogeneity. however, relationships that may exist between environmental and clinical strains are unknown. herein, we developed an efficient genotyping system based on four highly variable genomic sequences (hvgss) selected on the basis of genome comparison. we analysed 39 samples from 39 patients with whipple's dis ... | 2008 | 18227256 |
| prosthetic hip infection caused by tropheryma whipplei. | we report a case of prosthetic hip infection due to tropheryma whipplei in a 74-year-old man not previously known to have whipple's disease. diagnosis was based on systematic 16s rrna gene amplification and sequencing of samples obtained during revision hip arthroplasty. | 2008 | 18287323 |
| whipple's disease: new aspects of pathogenesis and treatment. | 100 years after its first description by george h whipple, the diagnosis and treatment of whipple's disease is still a subject of controversy. whipple's disease is a chronic multisystemic disease. the infection is very rare, although the causative bacterium, tropheryma whipplei, is ubiquitously present in the environment. we review the epidemiology of whipple's disease and the recent progress made in the understanding of its pathogenesis and the biology of its agent. the clinical features of whi ... | 2008 | 18291339 |
| [whipple's disease with segmental lesions in the proximal small intestine]. | a 67-year-old man with anemia was referred to our hospital. he had suffered from rheumatoid arthritis for ten years. two months before admission he had been an inpatient at another hospital because of heart failure. he presented with edema, slightly elevated temperature and effusion in the right knee. | 2008 | 18302096 |
| possible case of cns whipple's disease in an adolescent with aids. | an adolescent with hiv/aids presented subacutely with progressive encephalopathy, spastic quadraplegia, and diarrhea. his brain biopsy was suggestive of central nervous system whipple's disease, a disease rarely described in hiv patients. due to overlapping, nonspecific symptoms associated with several opportunistic infections and to the difficulty in culturing the causative organism tropheryma whipplei, whipple's disease may be more common than previously suspected, and it is an important consi ... | 2008 | 18319513 |
| [tropheryma whipplei and whipple disease: false positive pcr detections of tropheryma whipplei in diagnostic samples are rare]. | pcr can be used to detect t. whipplei (tw) in samples from variable tissue types and body fluids. we report clinical, evolutive characteristics and final diagnosis in patients with positive tw pcr assay. | 2008 | 18406018 |
| prevalence of asymptomatic tropheryma whipplei carriage among humans and nonhuman primates. | the reservoir of the agent of whipple disease is unknown. asymptomatic carriage of tropheryma whipplei in human stool and saliva is controversial. | 2008 | 18419351 |
| cardiac complications in whipple's disease. | whipple's disease or intestinal lipodystrophy is an infection induced by tropheryma whipplei. it is rare with an estimated incidence of 0.4 per million. symptoms are arthropathy, weight loss, and diarrhoea, but other organs notably the central nervous system may be affected. we demonstrate a case of cardiac complications in whipple's disease. the patient presented with endocardial infiltrations on tee examinations and heart failure and improved after antibiotic treatment. | 2008 | 18490346 |
| acquired resistance to trimethoprim-sulfamethoxazole during whipple disease and expression of the causative target gene. | whipple disease is a chronic infection caused by tropheryma whipplei. trimethoprim-sulfamethoxazole is recommended for treatment of whipple disease but is associated with treatment failure. t. whipplei is resistant in vitro to trimethoprim, because the gene targeted by this agent is missing. | 2008 | 18500934 |
| high prevalence of fastidious bacteria in 1520 cases of uveitis of unknown etiology. | the etiologic evaluation of uveitis is frequently unsuccessful when noninvasive methods are used. we conducted a prospective study to evaluate systematic screening for pathogens of uveitis. all patients with uveitis referred to the participating tertiary ophthalmology departments from january 2001 to september 2007 underwent intraocular and serum specimen collection. the standardized protocol for laboratory investigations included universal polymerase chain reaction (pcr)-based detection of any ... | 2008 | 18520326 |
| [reminiscences on the occasion of the whipple's disease centenary: a summary paper]. | the disease referred to eponymically as whipple's disease (wd) in medical literature was thoroughly described by the american physician and pathologist george hoyot whipple (1878-1976) in 1907 and given a temporary denomination of "intestinal lipodystrophy". according to literature, wd is rare, but its precise incidence has not yet been established. familial incidence of the disease is acknowledged, and its immunogenetic pathogenesis is assumed. the incidence ofwd is prevailingly observed in mid ... | 2008 | 18522299 |
| neurological presentation of whipple's disease after long-term antibiotic treatment: a case report. | whipple's disease is a rare systemic infectious disorder caused by tropheryma whipplei. | 2008 | 18522718 |
| whipple's disease-generalized stage. | whipple's disease is a chronic inflammatory systemic disorder in which all organs can be invaded by the rod-shaped bacterium tropheryma whipplei. it is a rare disease and frequently misdiagnosed, though there is no valid estimate of its actual incidence and prevalence. only about 1,000-1,500 cases have been reported. the clinical course of untreated whipple's disease can include three stages: (1) a non-specific prodromal stage which includes migratory polyarthralgias; (2) a classic abdominal man ... | 2008 | 18523887 |
| whipple disease: unusual presentation of a protean and sometimes confusing disease. | to describe an unusual case of whipple disease (wd) with confusing clinical features at onset and to discuss the diagnostic challenges for the clinician. | 2009 | 18538828 |
| [whipple's disease]. | whipple's disease is a rare infectious disease. this review describes the clinical picture, diagnostic aspects and treatment options. | 2008 | 18552903 |
| chorioretinitis and vitreitis due to tropheryma whipplei after transplantation: case report and review. | whipple's disease is a very rare chronic multisystemic bacterial disease characterized by diarrhea, malabsorption, fever, and polyarthritis. ocular manifestations occur very rarely. previous reports have suggested that the use of immunosuppressive drugs appears to accelerate or exacerbate the clinical course of whipple's disease; however, the illness has yet to be reported in the setting of transplantation. herein, we describe what we believe is the first reported case of whipple's disease after ... | 2008 | 18564981 |
| an atypical case of whipple's disease: case report and review of the literature. | we report the case of a 57-year-old man, presenting with bilateral panuveitis, bilateral sacroiliitis, intermittent pyrexia and a pulmonary nodule. the patient had been under immunosuppressive treatment for 2 years for behçet's disease. however, he did not fulfill the diagnostic criteria of behçet's disease. blood analysis showed a very high c reactive protein (crp at 34 mg/dl). in view of severe intra-ocular inflammation, the anterior chamber was punctured. polymerase chain reaction (pcr) on th ... | 2008 | 18575052 |
| serological microarray for a paradoxical diagnostic of whipple's disease. | whipple's disease is a systemic chronic infection caused by tropheryma whipplei. asymptomatic people may carry t. whipplei in their digestive tract and this can be determined by pcr, making serological diagnosis useful to distinguish between carriers and patients. putative antigenic proteins were selected by computational analysis of the t. whipplei genome, immunoproteomics studies and from literature. after expression, putative t. whipplei antigens were screened by microimmunofluorescence with ... | 2008 | 18594884 |
| value of tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of whipple disease: usefulness of saliva and stool specimens for first-line screening. | whipple disease (wd) is a chronic infectious disease caused by tropheryma whipplei. wd dna has been found in stool and saliva specimens from patients and asymptomatic carriers. | 2008 | 18662136 |
| [whipple's disease]. | whipple's disease is a chronic, multisystemic, curable, bacterial infection that usually affects middle-aged men. it has a wide range of clinical manifestations. in the historical presentation, weight loss and diarrhoea are the most common symptoms and are preceded in three-quarters of cases by arthritis for a mean of six years. long-term, unexplained, seronegative oligoarthritis or polyarthritis of large joints with a palindromic or relapsing course is typical. in most patients, periodic acid-s ... | 2009 | 18722696 |
| [macrophagic myofascitis vs atypical whipple's disease]. | a 39-year-old man presented pronounced asthenia and diffuse myalgias 8 months after a vaccination against the tetanus toxoid. muscle biopsy disclosed infiltration of the perimysium and endomysium by densely packed, pas-positive macrophages. tropheryma whippelii detection in blood and faeces allowed the initial assumption of atypical whipple's disease with isolated muscle involvement. however, the histological detection of aluminium-containing macrophages by means of morin stain immunofluorescenc ... | 2008 | 18726082 |
| whipple's disease: neurological relapse presenting as headache for two years. | whipple's disease is a rare, chronic, multi-systemic infectious disorder caused by the bacterium, tropheryma whipplei. relapses are commonly associated with neurological symptoms. we report a case of a 55-year-old man who presented with symptoms of progressive headache, 13 years after apparent complete recovery from intestinal whipple's disease. studies showed hydrocephalus with obstruction of the aqueduct and cerebrospinal fluid findings consistent with chronic meningitis. diagnosis of central ... | 2008 | 18784966 |
| diagnosis and management of whipple's disease of the brain. | whipple's disease of the brain is one of the most challenging neurological diagnoses. "is it whipple's disease?" is a frequent question, but rarely is the answer yes. the neurological manifestations do not help to distinguish primary from secondary whipple's disease of the brain, and although mr brain scanning with gadolinium is mandatory, it can be normal and any abnormalities are non-specific. there must be a comprehensive search for multisystem involvement such as raised inflammatory markers, ... | 2008 | 18796586 |
| whipple's disease: easily diagnosed, if considered. | patients present with arthralgia, abdominal pain, diarrhoea and weight loss. the disease is commonly diagnosed by histological examination of small bowel biopsies, especially after staining with periodic acid-schiff. because of the rarity of the disease, its diagnosis is not often considered. therefore the necessary investigations might be omitted. this case report might serve as a reminder for internists or gastroenterologists to consider whipple's disease in patients with abdominal, articular ... | 2008 | 18931401 |
| fourteen years of severe arthralgia in a man without gastrointestinal symptoms: atypical whipple's disease. | we report here the case of whipple's disease in a 60-year-old man with severe arthralgia and systemic disorders but without gastrointestinal manifestations. the patient had different clinical diagnoses over a period of 14 years. we identified tropheryma whipplei by real-time pcr. molecular typing was also performed by sequencing the 16s-23s rrna intergenic spacer region and domain iii of the 23s rrna gene. | 2009 | 19091811 |
| [microbiological diagnosis of emerging bacterial pathogens: anaplasma, bartonella, rickettsia, and tropheryma whipplei]. | ehrlichia/anaplasma, bartonella, rickettsia and tropheryma whipplei (formerly called whippelii) are fastidious bacterial organisms, considered the causative agents of potentially severe emerging and re-emerging diseases with repercussions on public health. the recent availability of advanced molecular biology and cell culture techniques has led to the implication of many of these species in human pathologies. these issues are extensively covered in number 27 of the seimc microbiological procedur ... | 2008 | 19100178 |
| [whipple's disease with normal duodenal histology and ankylosing spondylitis]. | a 33-year-old woman with increasing back pain was referred to our hospital 8 years ago. as she had ankylosing sacroilitis and peripheral arthritis she was diagnosed as having ankolysing spondylitis with involvement of the peripheral joints. she recently developed persistent diarrhea, abdominal symptoms and weight loss. | 2009 | 19148854 |
| erythema nodosum-like lesions in treated whipple's disease: signs of immune reconstitution inflammatory syndrome. | treatment of systemic infections due to mycobacteria and hiv infection can lead to paradoxical worsening, the immune reconstitution inflammatory syndrome, in a minority of patients. herein we describe a patient with whipple's disease, a chronic systemic inflammatory disease caused by tropheryma whipplei, who developed cutaneous and later ocular disease after initiation of antibiotic therapy. a 42-year-old man with a 12-year history of arthralgias presented with deteriorating health, including we ... | 2009 | 19150271 |
| the hla alleles drb1*13 and dqb1*06 are associated to whipple's disease. | whipple's disease is a systemic, chronic, relapsing disorder caused by a combination of environmental (tropheryma whipplei) and unknown host factors. because it is a rare disease, the association between hla type and whipple's disease has been studied in only small numbers of patients; these studies have led to conflicting results. we aimed to investigate whether disease phenotype and outcome are associated with hla type in 122 patients with whipple's disease. | 2009 | 19208355 |
| tropheryma whipplei glycosylation in the pathophysiologic profile of whipple's disease. | tropheryma whipplei is a bacterium commonly found in people with whipple's disease, a rare systemic chronic infection. in the present study, we hypothesized that bacterium glycosylation may impair the immune response. | 2009 | 19222368 |
| global proteomic pattern of tropheryma whipplei: a whipple's disease bacterium. | the proteome of tropheryma whipplei, the intracellular bacterium responsible for whipple's disease (wd), was analyzed using two complementary approaches: 2-de coupled with maldi-tof and sds-page with nanolc-ms/ms. this strategy led to the identification of 206 proteins of 808 predicted orfs, resolving some questions raised by the genomic sequence of this bacterium. we successfully identified antibiotic targets and proteins with predicted n-terminal signal sequences. additionally, we identified a ... | 2009 | 19253299 |
| resistance to trimethoprim/sulfamethoxazole and tropheryma whipplei. | whipple's disease (wd) is a chronic infection caused by tropheryma whipplei. a 1-year treatment of oral trimethoprim/sulfamethoxazole (sxt) is commonly used. advances in the culture of t. whipplei have allowed for full genome sequencing and antibiotic susceptibility testing, which has demonstrated resistance of t. whipplei to trimethoprim. several mutations in the folp gene that encodes dihydropteroate synthase, the target of sulphonamides, has been reported for one patient with clinically acqui ... | 2009 | 19346107 |
| tropheryma whipplei infection. | whipple's disease was initially described in 1907. over the next century, the clinical and pathological features of this disorder have been better appreciated. most often, weight loss, diarrhea, abdominal and joint pain occur. occasionally, other sites of involvement have been documented, including isolated neurological disease, changes in the eyes and culture-negative endocarditis. in the past decade, the responsible organism tropheryma whipplei has been cultivated, its genome sequenced and its ... | 2009 | 19418579 |
| multisegmental spondylitis due to tropheryma whipplei: case report. | we report a patient who presented with inflammatory back pain due to multisegmental spondylitis. following a vertebral biopsy which failed to detect an infectious organism, the patient was treated with etanercept, a tumor necrosis factor (tnf)-alpha inhibitor, for suspected undifferentiated spondyloarthritis. the back pain worsened and the spondylitic lesions increased. only in a vertebral rebiopsy with polymerase chain reaction (pcr) amplification of tropheryma whipplei, the causative agent of ... | 2009 | 19493331 |
| tropheryma whipplei in fecal samples from children, senegal. | we tested fecal samples from 150 healthy children 2-10 years of age who lived in rural senegal and found the prevalence of tropheryma whipplei was 44%. unique genotypes were associated with this bacterium. our findings suggest that t. whipplei is emerging as a highly prevalent pathogen in sub-saharan africa. | 2009 | 19523292 |
| [first centenary of whipple's disease]. | whipple's disease is an infrequent multisystemic infection caused by a gram-positive bacterium: tropheryma whippelii, which after several studies has been characterized as an actinomiceto por 16sr rna. it occurs with multiple symptoms, the principal of which are diarrhea, weight loss, stomach pain and arthralgias. arthritis or artralgia may appear as an isolated symptom and eventually through the years additional digestive, cardiovascular and/or neurological symptoms arise. diverse immunological ... | 2009 | 19623786 |
| a paradoxical tropheryma whipplei western blot differentiates patients with whipple disease from asymptomatic carriers. | tropheryma whipplei is a bacterium that causes whipple disease. however, t. whipplei can be carried in the gut of asymptomatic people, which may lead to difficulty in the interpretation of positive stool sample test results. | 2009 | 19635029 |
| impaired immune functions of monocytes and macrophages in whipple's disease. | whipple's disease is a chronic multisystemic infection caused by tropheryma whipplei. host factors likely predispose for the establishment of an infection, and macrophages seem to be involved in the pathogenesis of whipple's disease. however, macrophage activation in whipple's disease has not been studied systematically so far. | 2010 | 19664628 |
| real-time pcr strategy and detection of bacterial agents of lymphadenitis. | the aim of this study was to compare 16 s rrna gene amplification and sequencing with a systematic real-time pcr assay screening strategy that includes all common known pathogens recovered from lymph node biopsy specimens. lymph node biopsy samples sent to our laboratory from january 2007 to december 2008 were tested in the study. lymph nodes were screened for the presence of any bacteria by pcr amplification and sequencing targeting the 16 s rrna gene and also by a specific real-time pcr strate ... | 2009 | 19685089 |
| endocarditis due to tropheryma whipplei: rapid detection, limited genetic diversity, and long-term clinical outcome in a local experience. | the characteristic features of whipple's disease include abdominal pain, diarrhoea, wasting, and arthralgias, with the causative agent, tropheryma whipplei, being detected mainly in intestinal biopsies. pcr technology has led to the identification of t. whipplei in specimens from various other locations, including the central nervous system and the heart. t. whipplei is now recognized as one of the causes of culture-negative endocarditis, and endocarditis can be the only manifestation of the inf ... | 2010 | 19732090 |
| false-positive pcr detection of tropheryma whipplei in cerebrospinal fluid and biopsy samples from a child with chronic lymphocytic meningitis. | we report the case of a teenager with chronic lymphocytic meningitis for whom tropheryma whipplei 16s rrna pcr results were positive in two cerebrospinal fluid samples and one duodenal biopsy specimen. pcr targeting another specific sequence of tropheryma whipplei and sequencing of the initially amplified 16s rrna fragment did not confirm the results. | 2009 | 19741072 |
| efficacy of ceftriaxone or meropenem as initial therapies in whipple's disease. | whipple's disease is a chronic infection caused by the actinomycete tropheryma whipplei. we conducted a randomized controlled trial of the efficacy of antimicrobials that are able to cross the blood-brain barrier and to which t whipplei is susceptible. | 2010 | 19879276 |
| new insights into whipple's disease - a rare intestinal inflammatory disorder. | whipple's disease (wd) is a rare systemic infectious disorder caused by the actinomycete tropheryma whipplei. this chronic disease, first described by whipple as 'intestinal lipodystrophy', affects preferentially middle-aged white men who may present with weight loss, diarrhea, abdominal pain and arthralgia. thus, it represents an important differential diagnosis of chronic diarrhea. a variety of other clinical patterns, such as involvement of the heart, lung, or central nervous system (cns), ar ... | 2009 | 19897965 |
| renal amyloidosis in whipple disease: a case report. | whipple disease is a rare systemic infection caused by tropheryma whippelii that usually manifests with joint pain, weight loss, diarrhoea and abdominal pain. however, in some cases the infection may involve other organs and tissues. | 2009 | 19918433 |
| [unexplained lymphadenopathy: whipple disease]. | a 58-year-old man was referred to the internal medicine outpatient department because of abdominal pain and lymphadenopathy. ct imaging revealed multiple mediastinal, para-aortic, mesenteric and pelvic lymphoma. biopsy of an inguinal lymph node for histology purposes revealed granulomatous lymphadenitis. a watchful waiting approach was adopted. two and a half years after first presentation, the patient presented with weight loss, fever and night sweats. ct imaging showed progressive lymphadenopa ... | 2009 | 19930747 |
| [from whipple's disease to tropheryma whipplei infections]. | the first successful culture of tropheryma whipplei made 10 years ago opened the way for identification of the bacterium and the development of many diagnostic tools. phylogenetic analyses made it possible to classify it among gram positive bacilli in the family of actinomycetes, close to other ubiquitous bacteria of the environment. more than one century later, in the first description of whipple's disease, t. whipplei was found to be responsible for a broad spectrum of clinical presentations. ... | 2010 | 20079990 |
| type i interferon induction is detrimental during infection with the whipple's disease bacterium, tropheryma whipplei. | macrophages are the first line of defense against pathogens. upon infection macrophages usually produce high levels of proinflammatory mediators. however, macrophages can undergo an alternate polarization leading to a permissive state. in assessing global macrophage responses to the bacterial agent of whipple's disease, tropheryma whipplei, we found that t. whipplei induced m2 macrophage polarization which was compatible with bacterial replication. surprisingly, this m2 polarization of infected ... | 2010 | 20090833 |
| endocarditis due to tropheryma whipplei. | 2010 | 20109430 | |
| tropheryma whipplei in patients with pneumonia. | tropheryma whipplei is the etiologic pathogenic agent of whipple disease (wd), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. pcr-based methods for diagnosis of wd have been developed. t. whipplei has been identified in saliva and stool samples from patients with wd and from healthy persons. t. whipplei dna has also been found in bronchoalveolar lavage (bal) samples of a child with pneumonia. we detected dna of t. whipplei in 6 (3%) of ... | 2010 | 20113556 |
| review of microarray studies for host-intracellular pathogen interactions. | obligate intracellular bacteria are privileged soldiers on the battlefield that represent host-pathogen interactions. microarrays are a powerful technology that can increase our knowledge about how bacteria respond to and interact with their hosts. this review summarizes the limitations inherent to host-pathogen interaction studies and essential strategies to improve microarray investigations of intracellular bacteria. we have compiled the comparative genomic and gene expression analyses of obli ... | 2010 | 20188126 |
| whipple disease. | whipple disease (wd) is a rare disease caused by tropheryma whipplei. the classic profile of the patient is that of a middle-aged man presenting with fever, chronic diarrhea, and arthralgias. extragastrointestinal manifestations are not rare. a high degree of clinical suspicion for the disease is needed in atypical cases. trimethoprim-sulfamethoxazole is the treatment of choice. we present two patients with wd. the first presented with melena and generalized hyperpigmentation. the second had dep ... | 2010 | 20224490 |
| tropheryma whipplei in children with gastroenteritis. | tropheryma whipplei, which causes whipple disease, is found in human feces and may cause gastroenteritis. to show that t. whipplei causes gastroenteritis, pcrs for t. whipplei were conducted with feces from children 2-4 years of age. western blotting was performed for samples from children with diarrhea who had positive or negative results for t. whipplei. t. whipplei was found in samples from 36 (15%) of 241 children with gastroenteritis and associated with other diarrheal pathogens in 13 (33%) ... | 2010 | 20409366 |
| tropheryma whipplei. | 2010 | 20409378 | |
| whipple's disease: a rare disease revisited. | since the original postmortem diagnosis of "intestinal lipodystrophy" by dr. george h. whipple in 1907, the complexities of whipple's disease have been elucidated through case reports. universally fatal prior to the advent of antibiotics, tropheryma whipplei is increasingly recognized as an organism that can be treated only if the clinician seeks to identify it. whipple's disease is primarily a gastrointestinal disease manifesting as a malabsorption syndrome, and is detected through endoscopy an ... | 2010 | 20532708 |
| comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. | background. blood culture-negative endocarditis (bcne) may account for up to 31% of all cases of endocarditis. methods. we used a prospective, multimodal strategy incorporating serological, molecular, and histopathological assays to investigate specimens from 819 patients suspected of having bcne. results. diagnosis of endocarditis was first ruled out for 60 patients. among 759 patients with bcne, a causative microorganism was identified in 62.7%, and a noninfective etiology in 2.5%. blood was t ... | 2010 | 20540619 |
| tropheryma whipplei in the skin of patients with classic whipple's disease. | positive tropheryma whipplei pcr results in skin biopsies were frequent in patients with classic whipple's disease without skin manifestations. the bacterium was alive, as a strain was successfully cultured. the skin may be a reservoir for t. whipplei and may be helpful in the non-invasive diagnosis of the disease. | 2010 | 20600302 |
| failure and relapse after treatment with trimethoprim/sulfamethoxazole in classic whipple's disease. | classic whipple's disease is a chronic disease caused by tropheryma whipplei. a recent study reported that intravenous treatment with ceftriaxone or meropenem followed by a 1 year treatment with trimethoprim/sulfamethoxazole cured all patients. however, we have previously reported that t. whipplei is poorly susceptible to beta-lactams and resistant to trimethoprim. herein, we want to evaluate these antibiotic regimens. | 2010 | 20639526 |
| a new piece added to the whipple puzzle: tropheryma whipplei primary infection with bacteremia and cough. | 2010 | 20658940 | |
| tropheryma whipplei bacteremia during fever in rural west africa. | tropheryma whipplei not only causes whipple disease but also is an emerging pathogen associated with gastroenteritis and pneumonia that is commonly detected in stool samples in rural west africa. we investigated the role of t. whipplei in febrile patients from rural senegal who had a negative test result for malaria. | 2010 | 20658941 |
| tropheryma whipplei tricuspid endocarditis: a case report and review of the literature. | abstract: | 2010 | 20684779 |
| specific and nonspecific b-cell function in the small intestines of patients with whipple's disease. | whipple's disease is a chronic multisystemic infection caused by tropheryma whipplei that is characterized by arthritis, weight loss, and diarrhea. the immunological defects in the duodenal mucosa, the site of major replication of the agent underlying the pathogenesis of whipple's disease, are poorly understood. mucosal immunoglobulins are essential for the defense against intestinal pathogens; therefore, we analyzed the b-cell response in duodenal specimens and sera of whipple's disease patient ... | 2010 | 20696822 |
| genome analysis as a new and powerful tool to design suitable culture media. application to tropheryma whipplei. | extract: tropheryma whipplei is a gram-positive human pathogen that is the causative agent of whipple's disease. there have been a number of important findings about this bacterium in the past 13 years. in 2000, almost a century after the initial description of the disease by whipple in 1907, we succeeded for the first time in isolating and propagating this bacterium from the cardiac valve of a patient with endocarditis. this bacterium is particularly recalcitrant to cultivation. survival and re ... | 2003 | 20704857 |
| new insights into whipple's disease and tropheryma whipplei infections. | whipple's disease is a rare multi-systemic disease associated with the ubiquitous environmental bacterium tropheryma whipplei. over the last 10 years, since the isolation of the bacterium, recent advances in medical microbiology, epidemiology and cellular biology have provided major insights into the understanding of the pathophysiology of t. whipplei infections that may result in whipple's disease. | 2010 | 20708091 |
| systemic tropheryma whipplei: clinical presentation of 142 patients with infections diagnosed or confirmed in a reference center. | culture of tropheryma whipplei, the agent of whipple disease (wd), was achieved in our laboratory in 2000, allowing new perspectives for the diagnosis of this disease and for the description of other potential clinical manifestations caused by this microorganism. since 2000, we have developed new tools in our center in marseille, france, to optimize the diagnosis of t whipplei infections. classic wd was characterized by positive periodic acid-schiff performed on duodenal biopsy. in the absence o ... | 2010 | 20827111 |
| il-16 promotes t. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation. | the replication of tropheryma whipplei (the agent of whipple's disease) within human macrophages is associated with the expression of il-16, a cytokine known for its chemotactic and inflammatory properties. in this study, we asked whether il-16 acts on t. whipplei replication by interfering with the endocytic pathway. we observed that in macrophages, t. whipplei was located within late phagosomes that were unable to fuse with lysosomes; in monocytes, t. whipplei was eliminated in phagolysosomes. ... | 2010 | 21042409 |
| [of bugs and joints : oligoarthritis caused by tropheryma whipplei.] | whipple's disease is a rare, chronic infection caused by tropheryma whipplei, an ubiquitary gram positive bacterium. the disease is associated with a high mortality in absence of an antibiotic treatment. the disease can be detected in affected tissues and body fluids by light and electron microscopy, as well as by polymerase chain reaction (pcr). musculoskeletal symptoms such as arthralgia and arthritis frequently represent the first manifestation of this multi-system disease; typical subsequent ... | 2010 | 21046063 |
| whipple's disease. a classic case report and review of the literature. | we report the case of a 43-year-old carpenter with abdominal complaints and progressive weight loss. the hla-b27 positive male had been suffering migratory arthropathy for five years, only partially under control with corticosteroids and methotrexate therapy. endoscopic investigation showed dark staining of the duodenal mucosa and the ileal mucosa had an erythematous aspect with multiple white spots. abundant periodic acid schiff positive macrophages were seen on histologic examination of biopsy ... | 2010 | 21086946 |
| the immune reconstitution inflammatory syndrome in whipple disease: a cohort study. | whipple disease, which is caused by infection with tropheryma whipplei, can be treated effectively with antimicrobials. occasionally, inflammation reappears after initial improvement; this is often interpreted as refractory or recurrent disease. however, polymerase chain reaction for t. whipplei in tissue is sometimes negative during reinflammation, indicating absence of vital bacteria, and this reinflammation does not respond to antimicrobials but does respond to steroids. | 2010 | 21135294 |
| an immunoproteomic approach for identification of clinical biomarkers of whipple's disease. | whipple's disease (wd) is a chronic multisystemic infection, caused by the bacterium tropheryma whipplei. the main clinical presentations are classic wd (cwd) with histologic lesions in the gastrointestinal tract, endocarditis, and isolated neurologic infection. the current strategy for diagnosis remains invasive.the present study aimed to select the protein candidates for serological diagnosis of wd. the first step was to identify candidate proteins by an immunoproteomic approach combining 2-de ... | 2008 | 21136854 |
| [infective endocarditis as the only manifestation of whipple's disease: an atypical presentation.] | diagnosis of whipple's disease is difficult, and thus its frequency is probably underestimated, particularly in culture-negative infective endocarditis. however, it must be systematically searched for in such a situation, first because it is associated with a poor natural outcome, and second because tropheryma whipplei is not covered by the conventional empirical therapy recommended for culture-negative infective endocarditis. whipple's disease endocarditis is usually associated with weight loss ... | 2011 | 21272853 |
| complete genome sequence of cellulomonas flavigena type strain (134). | cellulomonas flavigena (kellerman and mcbeth 1912) bergey et al. 1923 is the type species of the genus cellulomonas of the actinobacterial family cellulomonadaceae. members of the genus cellulomonas are of special interest for their ability to degrade cellulose and hemicellulose, particularly with regard to the use of biomass as an alternative energy source. here we describe the features of this organism, together with the complete genome sequence, and annotation. this is the first complete geno ... | 2010 | 21304688 |
| tropheryma whipplei, the whipple's disease bacillus, induces macrophage apoptosis through the extrinsic pathway. | tropheryma whipplei, the etiological agent of whipple's disease, is an intracellular bacterium that infects macrophages. we previously showed that infection of macrophages results in m2 polarization associated with induction of apoptosis and interleukin (il)-16 secretion. in patients with whipple's disease, circulating levels of apoptotic markers and il-16 are increased and correlate with the activity of the disease. to gain insight into the understanding of the pathophysiology of this rare dise ... | 2010 | 21364641 |
| intestinal lymphangiectasia in adults. | intestinal lymphangiectasia in the adult may be characterized as a disorder with dilated intestinal lacteals causing loss of lymph into the lumen of the small intestine and resultant hypoproteinemia, hypogammaglobulinemia, hypoalbuminemia and reduced number of circulating lymphocytes or lymphopenia. most often, intestinal lymphangiectasia has been recorded in children, often in neonates, usually with other congenital abnormalities but initial definition in adults including the elderly has become ... | 2011 | 21364842 |