Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| discharge of mycobacterium leprae from the mouth in lepromatous leprosy patients. | 1979 | 370480 | |
| [study of m. leprae ultrastructure in human leproma]. | 1979 | 371265 | |
| experimental lepromatous leprosy in the white-handed gibbon (hylobatus lar): successful inoculation with leprosy bacilli of human origin. | leprosy bacilli of human origin were inoculated into a white-handed gibbon by the i.v. and i.p. routes, and also locally into ears, testis and around an ulnar nerve. the animal was observed closely during a period of nearly 15 years and did not exhibit any clinical evidence of cutaneous or neurological disease. at death, a wide range of tissues was taken for bacterial counts and histological examination, and a disseminated and progressive infection was demonstrated. acid-fast bacilli were found ... | 1978 | 371653 |
| the brown animal sanatory institution. | 1979 | 372441 | |
| the effect of freezing and storage in liquid nitrogen on the viability and growth of mycobacterium leprae. | the effects of rapid and slow rates of freezing in liquid nitrogen, storage in liquid nitrogen for 12 months, and the rate of subsequent thawing on the viability and growth of m. leprae in the mouse footpad were studied. some loss of viability of m. leprae was detected, and this was found to be associated with the freezing process, rather than with storage or thawing. slow freezing was less deleterious than quick freezing, with a loss of viability of 90% compared with 98%. the growth pattern of ... | 1979 | 372533 |
| antigenic analysis of mycobacterium leprae. | about twenty distinct antigenic components have been demonstrated in mycobacterium leprae (m. leprae) by crossed immunoelectrophoresis against a rabbit antiserum produced by immunization with concentrated m. leprae antigen. this system allows a more detailed analysis of the antigenic relationship between m. leprae and other mycobacteria and a better characterization of the antigenic content of various m leprae preparations than with previously available anstisera of the antigenic content of vari ... | 1979 | 373076 |
| the role of macrophages in the lymphoproliferative response to mycobacterium leprae in vitro. | peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro to stimulation by mycobacterium leprae antigens. in contrast, we found that t cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to m. leprae. conversely, t cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. it seems, therefore, tha ... | 1978 | 373933 |
| comparative ultrastructure of mycobacterium leprae and mycobacterium lepraemurium cell envelopes. | the structural properties of the cell envelopes of mycobacterium leprae and mycobacterium lepraemurium were investigated by freeze-fracture, freeze-etching, and negative-staining techniques. freeze-fracture split the cell wall and exposed the internal features of the peptidoglycolipid mycosidic filamentous network. the cell membrane was also split into two asymmetric faces. the external fracture face was characterized by linear arrays of intramembranous particles, whereas the protoplasmic fractu ... | 1979 | 374395 |
| development of an anti-leprosy vaccine -- progress in dharmendra. | 1978 | 374867 | |
| towards development of a vaccine against leprosy. introduction. | 1978 | 374868 | |
| five cultivable mycobacterial strains giving blast transformation and leukocyte migration inhibition of leukocytes analogous to mycobacterium leprae. | 1978 | 374869 | |
| delayed hypersensitivity skin reactions to homologous and heterologous antigens in guinea-pigs immunized with m. leprae and four selected cultivable mycobacterial strains. | 1978 | 374870 | |
| ability of m. leprae, mycobacterium w, and icrc bacillus to produce macrophage activating factors from lymphocytes of leprosy patients. | 1978 | 374871 | |
| delayed hypersensitivity skin reactions to lepromin and antigens prepared from four other mycobacteria. | 1978 | 374872 | |
| results of skin tests with five different mycobacteria. | 1978 | 374873 | |
| delayed hypersensitivity skin reactions to lepromins prepared from m. leprae and selected cultivable mycobacteria. investigations at the victoria hospital, dichpalli. | 1978 | 374874 | |
| early and late reactions in tuberculoid and lepromatous leprosy patients with lepromins from mycobacterium leprae and five selected cultivable mycobacteria. | 1978 | 374875 | |
| comparative study of skin reactions in leprosy patients to m. leprae-lepromin and to antigens from cultivable saprophytic mycobacteria. | 1978 | 374876 | |
| concluding comments on development of a vaccine against leprosy. | 1978 | 374877 | |
| assessment of dharmendra antigen. | 1978 | 374878 | |
| respiratory system involvement in leprosy. | 1979 | 376452 | |
| fluorescence microscopy for detection of m. leprae in tissue sections. | the fluorescence method was compared with the fite-faraco method for detecting acid-fast microorganisms in paraffin sections of cases of leprosy. biopsies were obtained from 50 cases of leprosy covering all varieties and at varying stages of treatment. the fluorescence method was better than the fite-faraco method; 22 biopsies showing acid-fast organisms in fluorescence microscopy and 20 in the fite-faraco method. its superiority was evidenced in two cases in which the organisms were very scanty ... | 1979 | 376453 |
| therapeutic effects of adding rimactane (rifampicin) 450 milligrams daily or 1200 milligrams once monthly in a single dose to dapsone 50 milligrams daily in patients with lepromatous leprosy. | 1979 | 376454 | |
| leprosy-like disease of wild armadillos in french acadiana, louisiana. | 1978 | 376833 | |
| use of a common indian herb "mandukaparni" in the treatment of leprosy. a preliminary report. | 1979 | 376942 | |
| the role of macrophages in leprosy as studied by protein synthesis of macrophages from resistant and susceptible hosts--a mouse and human study. | 3h-leucine uptake by macrophages from swiss white and c57bl mice before and after m. leprae infection was studied. a depression in 3h-leucine uptake after infection was observed only in swiss white mice. 3h-leucine uptake was also studied in blood derived macrophages from normals, and ll and tt patients. a depression was obtained in 3h-leucine uptake after m. leprae infection in macrophages from ll patients. | 1979 | 376943 |
| histopathologic study of clinically normal appearing skin in lepromatous leprosy. | skin biopsies from clinically normal skin of the scalp, axillary and groin regions in 20 lepromatous leprosy patients revealed significant histopathological findings in upto 25 percent of the patients. the positive findings could, perhaps, be enhanced by studying larger skin materials from these body areas. indeed, no skin area appears to be immune from invasion by myco. leprae. | 1979 | 376944 |
| the significance of changes in the nasal mucosa in indeterminate, tuberculoid and borderline leprosy. | a study of nasal biopsies from 137 leprosy patients classified on the basis of clinical, microbiological and skin biopsy as indeterminate, tuberculoid, borderline-tuberculoid and borderline-leproma was undertaken. changes suggestive of leprosy viz., nerve and smooth muscle inflammation with a few acid fast bacilli in a proportion of the biopsies were seen in all groups of patients examined. this suggests, that even in indeterminate and tuberculoid leprosy the disease becomes generalised by the t ... | 1979 | 376945 |
| induction of cell-mediated immunity to mycobacterium leprae in guinea pigs. | guinea pigs immunized with intact or disrupted armadillo-grown human mycobacterium leprae administered in aqueous or oil vehicles were tested with various dilutions of m. leprae suspended in saline, water-soluble m. leprae extract, purified protein derivative, and a water-soluble extract of normal armadillo tissue. the results demonstrated the following. (i) under no conditions was any skin test reactivity found to normal armadillo tissue extract. (ii) positive sensitization to both m. leprae an ... | 1979 | 378838 |
| lymphocyte transformation test in healthy contacts of patients with leprosy. i. influence of exposure to leprosy within a household. | fifty-three household contacts of lepromatous patients, 37 household contacts of tuberculoid patients, and 91 control persons were examined with the lymphocyte transformation test (ltt) for their responses to whole and sonicated antigen preparations from m. leprae, to bcg, m. avium, m. gordonae, and phytohemagglutinin (pha). the study was carried out in the gurage area of ethiopia in 15 households with a leprosy patient and 15 matched control households. household contacts of lepromatous patient ... | 1979 | 378871 |
| lymphocyte transformation test in healthy contacts of patients with leprosy. ii. influence of consanguinity with the patient, sex, and age. | the study was carried out in the gurage area of ethiopia, where 53 household contacts of lepromatous patients, 37 household contacts of tuberculoid patients, and 91 control persons were examined with the lymphocyte transformation test (ltt) for their responses to whole and sonicated antigen preparation from m. leprae to bcg, m. avium, m. gordonae and phytohemagglutinin. the potential influence of host factors, namely the state of consanguinity with the leprosy patient, sex and age on the ltt res ... | 1979 | 378872 |
| committee 2: workshop on the microbiology of leprosy. | 1979 | 378875 | |
| committee 4: workshop on experimental chemotherapy of leprosy. | 1979 | 378876 | |
| research in leprosy. a report of a committee set up by the medical research council to study future prospects. | recommendations for future research in leprosy include (i) cultivation of m. leprae in vitro; (ii) genetic control of susceptibility, including twin studies and hla typing; (iii) precise antigenic analysis of m. leprae; (iv) mechanisms involved in the macrophage response to mycobacterial infections; (v) more use of experimental models such as normal mice infected with m. lepraemurium; (vi) reassessment of the protection afforded by bcg; (vii) assessment of protection afforded by killed (armadill ... | 1979 | 380853 |
| in vitro studies on biopsies from leprosy cases. | 1979 | 381188 | |
| comparative biochemistry and drug design for infectious disease. | in the past two decades, biochemistry and molecular biology have demonstrated the existence of potentially exploitable biochemical differences between etiologic agents of disease and their hosts. known differences between organism and host with respect to metabolism and polymer structure point to the detailed characterization of key proteins as the focus for the development of potential inhibitors. in the last decade, the methodology of the isolation, characterization, and inactivation of protei ... | 1979 | 382357 |
| interaction of mycobacterium leprae and mycobacteriophage d29. | this study of the interaction between mycobacterium leprae and the mycobacteriophage d29 showed that the viruses caused a patchy damage of cell wall structure and the accumulation in the host of internal crystalline structures. whether the observed ultrastructural alterations were caused by the replication of d29 was not clear. mitomycin c also caused the accumulation of crystalline structures in m. leprae. | 1978 | 382947 |
| immunological changes observed in indeterminate and lepromatous leprosy patients and mitsuda-negative contacts after the inoculation of a mixture of mycobacterium leprae and bcg. | this investigation was carried out to study the possibility of eliciting favourable immunological changes in small groups of mitsuda-negative patients with indeterminate leprosy, lepromatous patients who were bacteriologically negative after prolonged treatment with sulphones, and in mitsuda-negative contacts by means of stimulation with a mixture of autoclaved tissues from mycobacterium leprae-infected armadillos and living bcg. a radical change was observed in the specific immunological activi ... | 1979 | 383331 |
| delayed hypersensitivity responses in mice and guinea pigs to mycobacterium leprae, mycobacterium vaccae, and mycobacterium nonchromogenicum cytoplasmic proteins. | antigenic relationships between mycobacterium vaccae, m. nonchromogenicum, and m. leprae were examined in mice and guinea pigs injected with m. vaccae or m. nonchromogenicum suspensions. the growth of both organisms in outbred icr and four inbred mouse strains was followed up to 30 days. m. nonchromogenicum persisted in the livers and spleens of the inbred mice substantially better than did the m. vaccae population in the same mouse strains. a translucent colony variant of m. vaccae isolated fro ... | 1979 | 383613 |
| in vitro lymphocyte stimulation in leprosy; simultaneous stimulation with mycobacterium leprae antigens and phytohaemagglutinin. | 1979 | 385182 | |
| experimental leprosy with nude mice. | 1979 | 389919 | |
| behaviour of macrophages to mycobacterium leprae. a tissue culture study. | macrophage culture was performed on 45 healthy adults who were initially categorised on the basis of their lepromin reactivity using dharmendra antigen. there were 25 individuals in the lepromin positive group and 20 in the lepromin negative group. the cultures were challenged with m. leprae and the macrophages studied at varying time intervals of culture. no difference was evident in the behaviour of cultured macrophages to m. leprae in both the groups. the lepra bacilli were phagocytosed by th ... | 1979 | 390240 |
| a study of scrotal biopsy in subsided cases of lepromatous leprosy. | scrotal biopsies were obtained from 38 cases of lepromatous leprosy who were clinically subsided and had negative skin smears. twenty six (68.4%) of these cases revealed bacilli in the dartos muscle. none except one showed a specific lesion in the dartos. bacilli obtained from 2 out of 7 cases multiplied in the mouse foot-pad. bacilli were found to be persisting in the dartos muscle despite prolonged treatment before as well as after clinical subsidence of the disease. the persisting bacilli in ... | 1979 | 390241 |
| [comparative study of the variable averages and bacilloscopic and morphologic indexes in virchowian hansen patients treated with rifampicin and diaminediphenylsulfone]. | 1979 | 390679 | |
| the significance of the presence of m. leprae in tuberculoid cases. | 1979 | 392190 | |
| systemic involvement in tuberculoid leprosy--pathogenesis of leprosy. | occurrence of leprous pathology/bacilli in the internal organs in cases of polar tuberculoid leprosy, support the systemic nature and haematagenous transmission and spread of the disease process. pathogenesis of leprosy has been postulated. | 1979 | 392191 |
| dapsone-resistant leprosy in ethiopia. | 1979 | 392212 | |
| palatal involvement in lepromatous leprosy. | 1979 | 392213 | |
| cultivation requirements for treponema pallidum, mycobacterium leprae and other microbial and mammalian microaerophilic cells. | atmospheric and biological evolution progressed simultaneously and today certain cell types flourish only at oxygen tensions which were ambient 600 million years ago, i.e., at 5 to 10 mm hg. in man, a continuous oxygen flow at these pressures is supplied in the skin where treponema pallidum, mycobacterium leprae and members of the genus rickettsia grow best. in vitro studies support the microaerophilic status of these organisms and of certain other microbial and mammalian cells. vigorous growth ... | 1979 | 392268 |
| [experimental transmission of m. leprae in mice treated with anti-lymphocyte serum (author's transl)]. | 1979 | 395145 | |
| [expermental transmission of m. leprae into the testes of mice born from 60co-irradiated pregnant mice]. | 1979 | 395146 | |
| advances in dermatology: 1--leprosy immunology. | 1979 | 395793 | |
| antibody activity against mycobacterium leprae antigen 7 in leprosy: studies on variation in antibody content throughout the spectrum and on the effect of dds treatment and relapse in bt leprosy. | 1979 | 396427 | |
| the saga of the skin smear. | 1979 | 397385 | |
| selection of sites for slit-skin smears. | 1979 | 397387 | |
| the fingers as sites of leprosy bacilli in pre-relapse patients. | 1979 | 397388 | |
| the development of an active vaccine against leprosy. | 1979 | 397704 | |
| lepromatous leprosy as a model of schwann cell pathology and lysosomal activity. | a brief illustrated account is presented of the light microscopic pathology, histochemistry of lysosomal enzymes, and fine structural changes in the nerves of patients with untreated or treated lepromatous leprosy. predominant bacillation of the schwann cells of unmyelinated fibres, degeneration of their axons, prominence of phagolysosomes, and disappearance of these cells with endoneurial collagenosis were observed on electronmicroscopic examination of the index branch of the radial cutaneous n ... | 1979 | 399208 |
| the relevance to protection of three forms of delayed skin-test response evoked by m. leprae and other mycobacteria in mice. correlation with the classical work in the guinea-pig. | the controversy surrounding the protective role of 'delayed hypersensitivity' in tuberculous guinea-pigs has never been resolved. this controversy has arisen because the term 'delayed hypersensitivity' is used indiscriminately to describe both a type of necrotic skin-test reactivity which does not appear until 4-6 weeks after infection, and also non-necrotic reactions which can be elicited within a few days. responses closely analogous to both have been characterized in mice immunized with mycob ... | 1979 | 399333 |
| phagosome/lysosome fusion: a possible prerequisite for the enhancement of antibody responses in vitro by bcg, mycobacterium leprae and corynebacterium parvum. | primary in vitro antibody responses to srbc were suppressed in cultures prepared from the spleens of cba mice injected i.v. 20 days previously with 10(8) liver bcg. in contrast, cultures prepared from mice injected with dead bcg showed enhanced responses. in vitro spleen cell responses of the mice had returned to normal levels 4--6 weeks after their injection, but if dead bcg, m. leprae or c. parvum was added to the cultures, responses were enhanced. the enhancing effect of the added bacteria co ... | 1979 | 399339 |
| do leprosy patients in papua new guinea take their dapsone? | 1979 | 399578 | |
| dapsone alone compared with dapsone plus rifampicin in short-term therapy of lepromatous leprosy. | 1977 | 400806 | |
| viability of mycobacterium leprae outside the human body. | 1977 | 400807 | |
| some characteristics of the action of dapsone on multiplication of mycobacterium leprae in the mouse. | 1977 | 400808 | |
| report of the third immlep scientific working group meeting. 21-25 february 1977. | 1977 | 400809 | |
| the treatment of leprosy today and tomorrow: the lepra consultation on chemotherapy. | 1977 | 400810 | |
| the hypothesis of skin to skin transmission. | 1977 | 400811 | |
| lack of protection afforded by ribonucleic acid preparations from mycobacterium tuberculosis against mycobacterium leprae infections in mice. | mycobacterial ribonucleic acid preparations from h37ra, an attenuated strain of mycobacterium tuberculosis, provide their usual marked protection against m. tuberculosis challenge; however, they provided no protection against mycobacterium leprae challenge. suspensions of intact h37ra were not effective against m. leprae. suspensions of bcg gave their usual distinct protection against m. leprae challenge. | 1977 | 404242 |
| o-diphenoloxidase in mycobacterium leprae. | 1977 | 406210 | |
| antibodies against bcg antigen 60 in mycobacterial infection. | a sensitive specific radioimmunoassay was developed to measure antibodies against bcg antigen 60, a prominent antigenic component of bcg bacilli which cross-reacts with similar components in many mycobacterial species including mycobacterium leprae and m tuberculosis. a lepromatous serum pool had anti-bcg-60 activity with a titre of 10(5) and the tuberculoid pool a titre of 10(4). testing of individual sera showed striking variations within groups of patients with lepromatous and tuberculoid lep ... | 1977 | 407965 |
| [research in the campaign against leprosy (author's transl)]. | "leprosy relief through leprosy research" means that the results of research are made available for curing and eradicating the disease. the "marinum model" and the "planter test in mice" are, along with determination of serum activity in healthy test subjects, part of a complex of experiments for the assessment of the therapeutic value of an antimycobacterial substance. this replaces the "controlled studies" which, in their proper form, are scarcely possible for leprosy. with the recently develo ... | 1977 | 408667 |
| a study of alleged leprosy bacillus strain hi-75. | subcultures of strain hi-75 of skinsnes leprosy bacillus received in antwerp and london have been studied bacteriologically and compared. both contained moderately large acid-fast bacilli readily subcultured and maintained on ordinary mycobacteriologic media. these organisms were found to be a variety of mycobacterium marianum (syn. serofulaceum) and were considered likely to be a laboratory contaminant. the earlier subculture studied also contained numbers of a much smaller mycobacterium (of a ... | 1977 | 409691 |
| induction of cell-mediated immunity to mycobacterium leprae in mice. | the immune response of mice to armadillo-derived, irradiation-killed mycobacterium leprae (i-ml) was investigated. following injection of 100 microgram of i-ml into the left hind footpads of mice, a state of cell-mediated immunity (cmi) was engendered to antigens of m. leprae. the evidence for cmi was as follows: (i) development of delayed-type hypersensitivity to both human tuberculin purified protein derivative and soluble m. leprae antigens; (ii) t-lymphocyte-dependent macrophage activation a ... | 1978 | 415009 |
| misconceptions about enzyme activity of mycobacterium leprae. | 1977 | 415179 | |
| criteria for establishing o-diphenoloxidase activity. | 1977 | 415992 | |
| the genetic hypothesis for susceptibility to lepromatous leprosy. | evidence for genetic influence of the host response to infection with mycobacterium leprae is reviewed. a complex segregation analysis is performed on data for 91 families from mactan, philippines, in each of which at least one offspring developed lepromatous leprosy. the data are not found to be inconsistent with an autosomal recessive hypothesis for susceptibility to lepromatous leprosy. heritability estimates in the range of 80% were calculated for sib-sib pairs under the multifactorial hypot ... | 1979 | 511131 |
| lack of observed association between armadillo contact and leprosy in humans. | in 1971 it was discovered that the nine-banded armadillo (dasypus novemcinctus) could be infected in the laboratory with mycobacterium leprae, and would manifest disease similar to the lepromatous form of leprosy in man. in 1975 several wild armadillos captured in louisiana were found to have a disease identical to the m. laprae infection in laboratory animals. to determine if there is a significant association between contact with armadillos and presence of leprosy in humans, the armadillo cont ... | 1977 | 557294 |
| cell-mediated immune response in mycobacterium leprae infected mice. | positive skin reactions to homologous antigens in mice infected with mycobacterium leprae were observed at the time that the bacillary multiplication was nearing the plateua level. once developed, the skin reactivity persisted for a considerable length of time. lymphocyte transformation studies indicated that the lymphocytes from infected animals were unable to respond to specific antigenic stimuli in the early phase of infection. possible explanation for this failure could be that the lymphocyt ... | 1977 | 562855 |
| serum and tissue lysozyme in leprosy. | mean serum lysozyme values were found to be elevated in untreated leprosy patients. statistically significant elevations were present in each of the three major categories of leprosy, tuberculoid, borderline, and lepromatous. values were particularly high in patients with severe reversal reactions or lucio's phenomenon. prolonged sulfone therapy was associated with a fall in serum lysozyme values. with an immunoperoxidase method to localize lysozyme in leprous tissues, two distinct staining patt ... | 1977 | 591069 |
| cutaneous leishmaniasis and leprosy. | eight patients who had concomitant leprosy and leishmaniasis are described. two patients with lepromatous leprosy had high resistance leishmaniasis, implying that the immune deficiency in lepromatous leprosy is specific to mycobacterium leprae. | 1978 | 653788 |
| reversal reaction in patients with lepromatous leprosy after transplantation of human fetal thymic grafts. | an attempt has been made to reconstitute impaired cell-mediated immunity in 1 patient with indeterminate, 4 patients with borderline and 2 patients with polar lepromatous leprosy by grafting three thymus glands obtained from human fetuses of 14--19 weeks gestation. most of these patients had severe ulcerative erythema nodosum leprosum (enl) and were intolerant to dapsone. after thymus transplantation these patients were followed for 1 1/2 years. during this period, all conventional chemotherapy ... | 1978 | 664571 |
| combinations of rifampicin and isoprodian in the treatment of mycobacterium leprae infections in mice. | 1978 | 701209 | |
| reversal reactions in lepromatous leprosy following transfer factor therapy. | five patients with active leprosy, four with polar lepromatous (ll) and one with borderline lepromatous (bl) disease, were each treated with transfer factor (tf) from approximately 7.4 x 10(9) lymphocytes given in 36 divided doses over a 12-week period. the tf was prepared from blood donated by normal, healthy, lepromin skin test-positive individuals. during treatment all four of the ll patients, but not the bl patient, developed clinical reversal reactions. histopathologically, skin biopsies in ... | 1978 | 717642 |
| gut-associated iga deficiency in lepromatous leprosy. | sera, intestinal secretions and intestinal biopsies were collected from twelve biopsy-proved lepromatous leprosy patients with the help of a capsule invented by roy choudhury. sera from another twenty-five proved lepromatous cases were also included. sera and intestinal aspirates from twenty-five normal subjects and twenty patients with intestinal tuberculosis were also taken as controls. acid-fast organisms, morphologically resembling mycobacterium leprae, were detected in the intestinal aspira ... | 1978 | 725534 |
| activity of derivatives and analogs of dapsone against mycobacterium leprae. | of 25 dapsone derivatives and analogs screened for activity against mycobacterium leprae in the mouse footpad system, only 7 were active. all seven were metabolized to or contaminated with dapsone. | 1978 | 727767 |
| immunological relatedness of ribosomes from mycobacteria, nocardiae and corynebacteria, and microorganisms in leprosy lesions. | serological relatedness of ribosomes from microorganisms of the mycobacterium, nocardia, and corynebacterium genera has been analyzed by the microplate immunodiffusion technique. mycobacterium and nocardia proved homogeneous and closely related taxa, whereas corynebacterium was found to be a heterogeneous phylum connected by remote links to the others. the taxonomic position of "diphtheroid microorganisms" (non-acid-fast, gram-positive bacteria morphologically similar to corynebactria), which we ... | 1978 | 730371 |
| development of hodgkin's disease in a patient with leprosy. | we present a patient with leprosy who developed hodgkin's disease of the nodular sclerosing type. there are two previous reports describing the combination of leprosy and hodgkin's disease in a single patient [3, 9]. hodgkin's disease was diagnosed 14 months after the complete disappearance of mycobacterium leprae from the skin lesions, under treatment with dds (diamino-diphenyl-sulfone). hodgkin's disease was treated by irradiation and chemotherapy. obstructive jaundice developed which resolved ... | 1978 | 745813 |
| bacteriological status (point prevalence) of lepromatous outpatients under sulfone treatment. | the study concerns 337 outpatients with lepromatous leprosy who had been receiving dapsone treatment for 1-26 years-69% of them regularly and 31% irregularly. routine bacterial examination (10 min per slide) by a paramedical technician showed only 50% of these patients to be bacteriologically positive. this rate attained 99% when each slide was examined for 30-60 min by a qualified bacteriologist. other factors-apart from the limited action of sulfones-might account for these unexpected results: ... | 1975 | 764995 |
| bacillaemia in leprosy. | 1975 | 765273 | |
| schwann cell changes in lepromatous leprosy--an electronmicroscope study. | 1975 | 765274 | |
| development of leprosy in another species of armadillo dasypus hybridus (l): genetic and immunologic implications. | 1975 | 765488 | |
| in vitro cultivation of leprosy bacilli on hyaluronic acid based medium. 1. preliminary report. | in vitro cultivation is reported of mycobacterium leprae on a medium (designated la-3) based on hyaluronic acid with additional ingredients of yeast extract, bovine albumin and glycerin together with phosphate buffer. the medium is also incorporated with agar or agarose (designated la-3p) to serve as culture plates. initial growth in la-3 in test tubes required about six weeks but subsequently this was speeded up to about two weeks utilizing large quantities of media with aeration by shaking twi ... | 1975 | 767262 |
| specific direct fluorescent antibody identification of mycobacterium leprae. | in vitro cultivation of m. leprae requires a rapid, specific identification procedure for monitoring the cultures. a method utilizing direct fitc-coupled lepromatous, specific serum globulin is described in detail with suggestions for improvement. after various purification and adsorption procedures, notably against human liver powder and m. tuberculosis, a fluorescent serum preparation is obtained which specifically reacts with m. leprae and not with other mycobacteria. | 1975 | 767263 |
| evidence for a soluble lymphocyte factor in the transplacental transmission of t-lymphocyte responses to mycobacterium leprae. | 1976 | 768774 | |
| susceptibility of mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. | in the course of a clinical trial of acedapsone therapy in 17 patients with lepromatous leprosy, the rate of response to therapy was measured by inoculation of mice with mycobacterium leprae recovered from biopsy specimens of skin lesions obtained before treatment and at intervals of 4, 12, and 24 weeks after institution of treatment. the susceptibility of each isolate of m. leprae to dapsone (4,4'-diaminodiphenylsulfone [dds]) was measured by passaging organisms that had multiplied in mice to n ... | 1976 | 769667 |
| recent advances in the immunology of leprosy. | 1976 | 770348 | |
| studies of the mouse foot pad technique for cultivation of mycobacterium leprae. 2. the relationship between incubation period and generation time. | 1976 | 772341 | |
| study of sulphone resistance in leprosy patients in india. | 1976 | 772342 | |
| effect of rifampin, clofazimine, and b1912 on the viability of mycobacterium leprae in established mouse footpad infection. | continuous dietary administration of rifampin to mice with an established mycobacterium leprae footpad infection reduced the bacillary solid ratio, with an estimated survival half-life of 5-6 days. in rifampin-treated immunosuppressed animals the survival half-life of solid bacilli, in the absence of host immunity, was 12-13 days. clofazimine and b1912 produced a significant effect on solid ratio only after a lag period of apparently 100 days. the rate of action was considerably slower than that ... | 1976 | 772686 |
| bactericidal action of dapsone against mycobacterium leprae in mice. | dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. m. leprae were harvested from these and also from control mice, diluted serially, and inoculated into additional mice. the organisms recovered from untreated mice multiplied in passage with a mean doubling time of 12.2 days, and 35% or more of the inoculated orga ... | 1976 | 773300 |