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determination of the bacteriostatic capacity of neutrophils and monocytes in mixed cell populations.cline [1, 2] described a method of determining the phagocytic and bacteriostatic activity of individual types of leukocytes within mixed cell populations. we tried to improve the applicability of this method for the investigation of clinical problems.--bacteria in the log-phase of growth were incubated in test tubes with leukocytes separated from venous blood. after a short period of phagocytosis 3h-thymidine was added to label dna-synthesizing organisms. smears were prepared and processed by au ...1977402962
cooperation of immune lymphoid and reticuloendothelial cells during listeria monocytogenes-mediated tumor immunity.listeria monocytogenes (lm) in admixture with cells from a murine, chemically induced tumor retarded local tumor development in the syngeneic host. intra-footpad growth of 10(4) tumor cells was equally inhibited by 4 x 10(4) admixed lm in normal or lm-immune mice indicating that concomitant or prior immunity to lm was equally effective in suppressing tumor growth. development of cellular immunity to viable lm was required for tumor rejection. mice prevented from developing anti-lm immunity by in ...1977403003
suppression of in vitro antibody responses by listeria primed spleen cells. 1977403012
cell-mediated resistance to infection with listeria monocytogenes in nude mice.congenitally dysthymic nude (nu/nu) nmri mice showed increased resistance to viable listeria monocytogenes cells during the initial phase of infection as compared with euthymic control mice. the intravenous mean lethal dose (ld50), as determined for euthymic mice after an observation time of 7 and 14 days, amounted consistently to 6 x 10(4) listeria. the corresponding values determined in nude mice were found to be increased by either 20-fold (1.2 x 10(6) listeria after an observation time of 7 ...1977403135
purification of a monocytosis-producing activity from listeria monocytogenes.the monocytosis-producing activity (mpa) from listeria monocytogenes is shown to be associated with the cell envelope. both mpa and immunosuppressive activity were readily extracted with aqueous solvents and separated as two independent activities by gel filtration and ion-exchange chromatography. as little as 10 microng of the resulting mpa-containing fraction caused a ninefold elevation in the level of circulating monocytes. the molecular weight of the fraction was approximately 22,000, and it ...1977403137
listeria monocytogenes: another look at the "cinderella among pathogenic bacteria". 1977403404
[electronenmicroscopic studies on cells of listeria monocytogenes treated with enterocin (author's transl)].purified enterocin e1a, a bacteriocin produced by streptococcus faecium e1, had a strong bactericidal activity on susceptible cells of listeria monocytogenes. electronmicroscopic observation of thin sections of l. monocytogenes, treated with enterocin e1a at a concentration that gave 0.1% survivors, revealed that the predominant features of morphological alterations concern the partial dissolution of the cell content and the damage of the cell envelope which enabled an efflux of cell-material. n ...1977403713
listeria revisited. 1977403758
partial purification and properties of an antibacterial product of peritoneal exudate cell cultures from bcg-infected guinea pigs.peritoneal exudates elicited in bcg-infected guinea pigs with caseinate yield cell cultures that have been shown to produce soluble material capable of sterilizing certain bacteria if the cultures are incubated with the specific antigen purified protein derivative or the lectin phytohemagglutinin. this material is now shown to have the following properties: (i) strongly adsorbable to glass; (ii) strongly adsorbable to cation- and not to anion-exchange resins but not elutable with mineral acid or ...1977404243
chromatographic study of mycolic acid-like substances in lipids of listeria monocytogenes. 1977404306
evaluation of the rapid hippurate hydrolysis test with enterococcal group d streptococci.the rapid hippurate hydrolysis test was evaluated with the conventional test, using 17 group a streptococci, 9 non-enterococcal group d streptococci, 108 enterococcal group d streptococci, and 2 strains of listeria monocytogenes. there was complete correlation between the rapid and conventional tests with all organisms except enterococcal group d. the rapid hippurate hydrolysis method was more sensitive with the enterococci; 95.4% were positive with the rapid method, and 9.3% were positive with ...1977404312
enhancement of carrier-mediated transport after immunologic activation of peritoneal macrophages.immunologically activated peritoneal macrophages from inbred mice and hartley strain guinea pigs demonstrate a markedly greater than normal transport of 2-deoxy-d-glucose and l-leucine. the degree of nutrilite transport enhancement was greatest when animals were injected with the appropriate eliciting antigens before harvesting and also, if antigen was included in the tissue culture medium during the initial hours of in vitro culture. enhanced hexose and amino acid uptake could also be achieved ...1977404359
enhancement of nonspecific immunity to bacterial infection by cord factor (6,6'-trehalose dimycolate).the capacity of mycobacteria to enhance the nonspecific resistance of mice to bacterial infections was related to the presence of cord factor. after enzymatic digestion and delipidation, cell walls lost their immunopotentiating activity, which was restored, however, by the addition of cord factor. cord factor administered alone protected mice effectively against virulent organisms unrelated to mycobacteria. moreover, although this glycolipid is usually injected as a solution in mineral oil, our ...1977404368
subversion of host defense mechanisms by malignant tumors: an established tumor as a privileged site for bacterial growth.mice carrying any one of three murine tumors in their right hind foot pad were incapable of eliminating an inoculum of the bacterial parasite listeria monocytogenes from the progressive tumor. in contrast, they were as capable as control mice in efficiently eliminating the organism from their contralateral tumor-free foot pad, and from their lymph nodes and livers. the results serve to show, therefore, that conditions within an established tumor are not only antagonistic to the expression of con ...1977404387
differential diagnosis between streptococcus agalactiae and listeria monocytogenes in the clinical laboratory.streptococci of the group b (s. agalactiae) and listeria monocytogenes resemble each other in many morphological and biochemical characteristics. ten beta-hemolytic strains of each species were subjected to 26 tests commonly and easily performed in the clinical laboratory. macroscopic and microscopic morphology on solid media showed differences only in the size of the colonies and in the length of the individual organisms. among many other tests, hippurate hydrolysis and the camp reaction were p ...1977404952
listeria monocytogenes endophthalmitis in an immune-suppressed host. 1977405090
listericidal activity of non-stimulated and stimulated human macrophages in vitro.an in vitro biological assay system has been described to quantify the listericidal activity of human macrophages grown from peripheral blood monocytes. within 15 min after in vitro infection, the activated macrophages showed a faster and higher degree in killing capacity as compared to the nonactivated ones; the killing process early and was of short duration.1977405167
age-related decline in the resistance of mice to infection with intracellular pathogens.resistance to infection with toxoplasma gondii and listeria monocytogenes in balb/c female mice decreased with increasing age. the decrease was apparent as early as 9 months of age and was more marked as the animals aged further. this age-related decline in resistance was not restricted to balb/c female mice, as male and female mice of the c57bl/6 strain exhibited similar responses. with both pathogens, aged mice showed a more marked susceptibility to the strain of lesser virulence. transfer of ...1977405325
bacterial endocarditis caused by listeria monocytogenes. 1977405800
[frequency and distribution of various serotypes of listeria monocytogenes in hungary]. 1977405810
[submicroscopic organization of listeriae during l-transformation].a study was made of the ultrastructural organization of listeria at the early stages of l-transformation, beginning from the first passage of the bacterial culture on solid nutrient medium with pencillin. the use of potassium benzylpenicillin salt in the capacity of an l-transforming agent permitted to observe the cells at various stages of l-transformation, beginning from the bacterial forms and ending with the typical l-colonies. it was shown that at the earliest stage of l-transformation ther ...1977405828
listeria monocytogenes endocarditis: report of a case and review of the literature.endocarditis due to listeria monocytogenes is rare with only 13 cases cited in the world's literature. we report an additional case with a review of the previously reported patients. in contrast to other clinical forms of listeriosis, endocarditis does not tend to occur in patients with severe underlying disorders or those on immunosuppressive regimens. listeric endocarditis has a predilection for left-sided cardiac involvement (100 percent), and systemic embolization is a major clinical feature ...1977405865
listeria monocytogenes endophthalmitis.listeria monocytogenes and a staphylococcus organism caused a catastrophic endophthalmitis in a patient despite appropriate local and systemic antimicrobial chemotherapy. although l monocytogenes is widespread in nature and has produced a variety of clinical illnesses, it has only one previously been reported to cause endophthalmitis. if appropriate microbiologic techniques are not employed, the organism may go unrecognized as an ocular pathogen.1977405962
differential effects of concanavalin a and phytohemagglutinin on murine immunity. suppression and enhancement of cell-mediated immunity. 1977406049
stimulation of macrophages by cord factor and by heat-killed and living bcg.trehalose-6,6'-dimycolate (cord factor; cf) injected into the peritoneal cavity of mice induced stimulation of the peritoneal macrophages, evidenced both by increased activity of the lysosomal enzyme, acid phosphatase, and by increased phagocytosis of listeria monocytogenes. the increase in enzyme activity and phagocytosis was similar to that induced by killed or living bcg. when administered intravenously, cf or bcg did not induce stimulation of peritoneal macrophages. cf when added to tissue c ...1977406198
an outbreak of caprine listeriosis in the western cape.listerial meningo-encephalitis (circling disease) is reported for the first time in ruminants in south africa. an account is given of the clinical signs, pathology and bacteriological confirmation of the disease.1977406392
[fulminat courses of sepsis in newborn infants and infants]. 1977406522
the influence of listeria monocytogenes cells on the primary immunologic response in irradiated mice.the influence of killed listeria monocytogenes cells on the primary immunologic response in mice irradiated with 300 or 500 r was studied. the immunologic response of the mice to sheep red blood cells used as antigen was assessed at the cellular level (by counting pfc) and humoral level. injection of killed listeria monocytogenes cells before irradiation of the mice diminished the immunosuppressive effect of roentgen radiation. injection of the cells after irradiation accelerated regeneration of ...1977406878
serological study of listeriosis in domestic animals in são paulo-brazil.a serological examination was carried out for l. monocytogenes antibodies on 9,318 domestic animal--7,809 bovine, 838 horses and 671 swine--in são paulo, brazil. serum agglutination in tubes was the method used. only somatic antigens from serotypes 1, 2, 3, 4a and 4b were employed. it was considered reagent all sera reacting in a titer 1/20 while as positive only sera with 1/320 or above. according this criteria the results showed showed that in cattle 17.8% were reagent but only 8 sera were pos ...1977407169
separation of pathogenic from apathogenic listeria monocytogenes by three in vitro reactions.one-hundred-twelve isolants of listeria monocytogenes cultured from clinical and nonclinical sources were examined for hemolytic activity by means of the camp phenomenon and tested for acidification of xylose and rhamnose. the reactions of the isolants were noted and correlated with the pathogenicity of the organisms. all of the camp-negative (nonhemolytic) isolants were apathogenic, and all but one of the camp-positive (hemolytic) isolants were pathogenic. all xylose-acidifying isolating isolan ...1977407244
[listeria monocytogenes antibodies in human sera in poland in the years 1970-1974]. 1977407630
[experimental studies on bacteria transmission via chicken egg]. 1977407900
[transfer of pathogenic activity of a virulent strain of listeria to an avirulent strain].the pathogenicity of a virulent strain of listeria monocytogenes was transfered to an avirulent strain by mixing the filtered culture of the pathogenic strain with an exponentially growing avirulent strain.1977408037
kinetics and maintenance of acquired resistance in mice to listeria monocytogenes.in the mouse system, acquired resistance to listeria monocytogenes can only be demonstrated after immunization with viable microorganisms. a successful state of immunity cannot be elicited with formalin-killed organisms or bacterial cell-derived products. viable, serologically cross-reactive organisms (not mouse pathogenic) do not induce a state of immunity as measured by acquired resistance. the duration of immunity, once established, is dose independent, and the absolute interval of its existe ...1977408273
cell-mediated immune response to lymphocytic choriomeningitis and vaccinia virus in rats.the parameters of cell-mediated immune responses of rats to infection with lymphocytic choriomeningitis virus or vaccinia virus were assessed by measuring primary footpad swelling, increased weights of the local lymph nodes, increased numbers of lymphocytes per lymph node, and the course of virus-specific cytolytic activity by these lymphocytes. except for lack of a defined swelling caused by vaccinia virus injected into the hind footpads of rats, the kinetics of all these responses correlated a ...1977408419
inhibition of different serotypes of listeria monocytogenes by enterocins in solid and liquid media.twenty-one enterocinogenic strains of enterococci were examined for their ability to inhibit 51 strains of listeria monocytogenes belonging to eight different serotypes; 50 strains of l. monocytogenes were uniformly inhibited on solid media and in broth cultures by strains of streptococcus faecium. however, only four strains of l. monocytogenes were inhibited by strains of streptococcus faecalis, s. faecalis v. zymogenes or s. faecalis v. liquefaciens. enterocin e1a prepared from the supernant f ...1977408493
[applicability of culture medium containing acriflavine for the isolation of listeria monocytogenes]. 1977408568
in vitro immunisation against human tumour cells with bacterial extracts. 1977408706
in vitro studies on normal, stimulated and immunologically activated mouse macrophages. iii. intracellular multiplication of listeria monocytogenes.the intracellular generation time of listeria monocytogenes is increased in monolayers of pe macrophages from mice immunized with bcg, listeria and t.a.b. vaccine as compared with monolayers of pe macrophages from normal mice stimulated intraperitoneally with proteosepeptone. thus non-specifically stimulated and immunologically activated macrophages, although sharing several other characteristics, differ in their capacity to control intracellular bacterial infection.1977409099
[meningitis due to "listeria monocytogenes": small postnatal outbreak (author's transl)].four cases of "listeria monocytogenes" serotype 4 neonatal meningitis are reported. in all, the study of maternal antecedents and the circumstances of their outcome as small epidemy suggest a raisonable evidence that postnatal contamination within the early twenty-four hours of life happened. a proper treatment succeded in complete healing without sequelae in all cases.1977409322
[isolation and characterization of "listeria monocytogenes" bacteriophages (author's transl)].fifteen l. monocytogenes phages are isolated from lysogenic strains without induction and are selected for phage-typing. four of these phages are produced by strains belonging to serotype 1/2a and 1/2b, eight by strains 4b and three other phages respectively by strains 4ab, 4g and 3c. electron micrographs of 5 of these phages show isometric heads with non contractile tails. they belong to morphological group b of bradley. rabbits are immunized with 7 bacteriophages and all the phages are studied ...1977409323
kinetics of phagocytosis and bacterial killing by human polymorphonuclear leukocytes and monocytes.the kinetics of phagocytosis and bacterial killing by normal human polymorphonuclear leukocytes (pmnls) and by monocytes (mns) were compared by use of [3h]thymidine-labeled staphylococcus aureus, escherichia coli, and listeria monocytogenes. the rate of phagocytosis by pmnls was approximately twice that by mns for all three bacterial species. although a marked difference was found in opsonic requirements for phagocytosis of s. aureus, e. coli, and l. monocytogenes, phagocytosis by pmnls and mns ...1977409787
secretion of mediators following t lymphocyte-macrophage interaction is regulated by the major histocompatibility complex.in this study we show that t cells from mice infected with listeria monocytogenes can interact in vitro with normal macrophages to produce a number of soluble mediators, including lymphostimulatory molecules. one of these molecules was a 15,000-dalton protein mitogenic for thymocytes. generation of mitogenic activity was essentially completed by the first 24 hr of culture and did not require the addition of listeria antigens. production of mitogenic protein required contact between the lymphocyt ...1977410022
[immunological defence mechanisms and inflammation (author's transl)].the interaction of immunological defence mechanisms and inflammation is reviewed. to begin with, those cells are discussed, which play a role in the immunological response, viz. the cells by which antigen is recognized (macrophages, b and t lymphocytes) and the effector cells (macrophages, plasma cells and sensitized t cells) and their products. then, the cells involved in an inflammatory response (neutrophilic, eosinophilic and basophilic granulocytes, mast cells) are discussed, attention also ...1977410115
spontaneous peritonitis of cirrhosis due to listeria monocytogenes. 1977410335
chemotaxigenesis and complement fixation by listeria monocytogenes cell wall fractions.data reported here show that a crude cell wall fraction of listeria monocytogenes (lcwf) and its purified derivative (pf) induce chemotaxis of human polymorphonuclear leukocytes in the presence of normal rabbit serum. in addition, both lcwf and pf can fix rabbit and guinea pig complement. the purified cell wall preparation is more active than lcwf in both chemotaxigenesis and complement fixation, indicating that these activities are due primarily to the nonprotein portion of lcwf. complement fix ...1977410883
a rapid micro method for the simultaneous determination of phagocytic-microbiocidal activity of human peripheral blood leukocytes in vitro.a new, simple technique for simultaneously studying phagocytic and microbiocidal functions, using viable eukaryotic and prokaryotic microbes, is described. fresh human venous blood from volunteers was placed on a coverglass and incubated to allow leukocyte adhesion to the coverglass. after clot removal, viable microbes in suspension were added and the coverglass preparation was incubated to allow phagocytosis. the excess microbes (e. coli, s. aureus, l. monocytogenes, and c. albicans each have b ...1977410889
killed listeria monocytogenes vaccine becomes protective on addition of polyanions. 1977411046
[selective effect of propolis in the isolation of listeria monocytogenes (author's transl)].propolis is a substance produced by honeybees. it is inhibitory to some bacteria species, mainly gram-positive bacteria, but less inhibitory to listeria monocytogenes (l.m) than to the other gram-positive bacteria tested. in order to obtain selective growth of l.m. from contaminated samples, the effect of propolis in plating media and broths on various strains of bacteria was examined. table i shows the effect of increasing concentrations of propolis in tryptose-agar (ta). l.m. tolerated higher ...1977411111
a new selective medium for the isolation of listeria monocytogenes.a new selective medium for the isolation of listeria monocytogenes (lm), is described. the medium contained propolis, nalidixic acid, polymyxin b and rivanol as selective substances. the new medium (propolis-agar) was compared with two other selective media and one nonselective medium. no inhibitory effect was found on the 6 strains of lm tested, and lm was easily isolated from a mixture of lm and contaminating bacteria. the selective effect was better than for the two other selective media test ...1977411112
a placental view of the diagnosis and pathogenesis of congenital listeriosis. 1977411374
listeria monocytogenes infection after renal transplantation.listeria monocytogenes infection has been observed in 13 patients, of a group of more than 700 renal transplants, treated during the past 13 1/2 years. the infection usually was manifested as bacteremia or meningitis. twelve of the 13 patients survived the infection; one died of brain-stem herniation due to increased intracranial pressure. the recommended treatment is intravenously given ampicillin sodium.1977411435
listeria monocytogenes endocarditis. 1977411437
effect of space flight on cell-mediated immunity. 1977411470
[infections of newborn infants. crucial points and trends]. 1977411722
potentiation of mouse peritoneal macrophage antibacterial functions by treatment of the donor animals with the methanol extraction residue fraction of tubercle bacilli.administration to inbred mice of the methanol extraction residue fraction of tubercle bacilli by some, but not by all, routes affected markedly the in vitro phagocytic and antibacterial capacities of their peritoneal macrophages harvested several days to weeks after treatment. phagocytosis of living [3h]thymidine- labeled staphylococcus albus and staphylococcus aureus organisms, but not of listeria monocytogenes, was markedly enhanced. uptake of the deoxyribonucleic acid precursor thymidine by t ...1977411756
[a case of sepsis and meningitis infected with listeria monocytogenes type 2 (author's transl)]. 1977411856
host resistance to the lvs strain of francisella tularensis in bcg vaccinated mice. 1977411926
enhanced resistance to listeria monocytogenes in splenectomized mice.mice infected with live listeria monocytogenes intravenously from 1 week to 3 months following splenectomy exhibit greatly enhanced antibacterial resistance to this micro-organism as compared to normal or sham-splenectomized mice. they survive a dose of listeria 100 times higher than is the ld50 of this parasite for normal mice. initially, the same number of viable micro-organisms lodge in the livers of splenectomized and normal hosts. however, within 24 h after infection, the number of viable l ...1977412778
anomalous high native resistance to athymic mice to bacterial pathogens.congenitally athymic (nude) mice exhibited an anomalous high resistance against infections with the facultative intracellular parasite listeria monocytogenes and other bacterial pathogens. protection against lethal infection was demonstrated to result from the presence of naturally occurring activated macrophages in the reticuloendothelial organs of the nude mice. this was exemplified after intravenous challenge by enhanced bacterial clearance from the blood and augmented bacterial killing in th ...1977412787
hyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophils.it has recently been demonstrated that fever, or hyperthermia, results in enhanced survival of lizards infected by aeromonas hydrophila. in the present study, the effects of hyperthermia on certain immune functions were assayed in vitro with purified human leukocytes. lymphocyte transformation responses to the mitogen phytohemagglutinin and the common antigen streptokinase-streptodornase were enhanced at 38.5 degrees c relative to 37 degrees c whether analyzed according to absolute counts per mi ...1977412788
immunofluorescent identification of listeria monocytogenes.a fluorescent antibody technique for the rapid diagnosis and identification of l. monocytogenes in smears, impression smears from tissues of animals dead from listeriosis, and in meat and milk is described. the technique could well be exploited for detecting l. monocytogenes in meat and meat products, animal tissues, and in milk provided that it is supplemented with adequate controls. the technique has been compared with conventional cultural technique and found to be superior as far as the time ...1977413282
[certain data on the protoplast ultrastructure].a study was made of the structure of bac. subtilis and listeria monocytogenes protoplasts by the method of scanning electron microscopy. the mechanism of protoplast formation in gram-positive bacteria and in spheroplasts of gram-negative bacteria proved to differ. a loss of the rigid form of the cell, round protrusions on cell surface, and an escape of the cytoplasm through the ruptured cell wall in some one place was noted in case of protoplasts. individual cells can coalesce with one another w ...1977413293
listeric septicaemia in sheep associated with tick-borne fever (ehrlichiosis ovis). 1977413348
rifampicin against experimental listeriosis in the mouse.the activity of rifampicin was compared with that of tetracycline, ampicillin, penicillin g, chloramphenicol, gentamicin and sulphadiazine in vitro and in experiments on mice infected with various strains of listeria monocytogenes. although the minimum inhibitory concentration of rifampicin was not appreciably lower than that of ampicillin, penicillin g and gentamicin, rifampacin was very much more active in vivo than any of these antibiotics. one of the reasons for its greater efficacy may be t ...1978413697
listeriosis in an arabian foal with combined immunodeficiency.a 1-month-old arabian foal with signs of central nervous system disease was found to have combined (b- and t-lymphocyte) immunodeficiency. the foal died in spite of intensive antibiotic therapy. at necropsy, generalized lymphoid hypoplasia and acute necrotizing and granulomatous inflammation of the brain, heart, and adrenal glands were found. in addition, there were spinal meningitis and focal hepatic necrosis. listeria monocytogenes was isolated on primary culture from the brain.1978413818
[incidence of listeria monocytogenes in the intestinal contents of broilers on different farms (author's transl)].the intestinal contents of 3,090 broilers, one day to five weeks of age, from 1,025 broiler houses, were examined for the presence of listeria monocytogenes. l. monocytogenes was isolated in 243 cases, i.e. 23.7% of the broiler houses, 58.8% were of type 1, 35.5% of type 4b, 1.2% were of type 5 and 2.4% of the strains could not be typed. in spite of cleaning and disinfection after the chickens had been taken to the poultry slaughterhouse, reinfection occurred in the broiler houses in 16.9% of th ...1978414373
[new serovariants and/or antigen combinations of listeria monocytogenes (author's transl)].in 2111 samples of human faeces originating from 932 persons (midwives, pregnant women, slaughterhouse workers, laboratory workers, individuals with gastroenteritis and without specific symptoms) a total of 86 (9.22%) carriers of l. monocytogenes could be found. serotyping revealed prevalence of serovar 1/2a (39%) which was characterized by beta-hemolysis and mouse pathogenicity; serovar 4b and 5, also showing beta-hemolysis and mouse pathogenicity, were met with in 11% and 2% of cases, respecti ...1977414480
induction of cell-mediated immunity to mycobacterium leprae in mice.the immune response of mice to armadillo-derived, irradiation-killed mycobacterium leprae (i-ml) was investigated. following injection of 100 microgram of i-ml into the left hind footpads of mice, a state of cell-mediated immunity (cmi) was engendered to antigens of m. leprae. the evidence for cmi was as follows: (i) development of delayed-type hypersensitivity to both human tuberculin purified protein derivative and soluble m. leprae antigens; (ii) t-lymphocyte-dependent macrophage activation a ...1978415009
listeria monocytogenes meningitis: case report.a case of listeria monocytogenes septicaemia with meningitis is described. predisposing factors in this case included chronic liver disease, diabetes mellitus and liver malignancy. the infection responded poorly to ampicillin.1977415268
[persistence of listeria monocytogenes in the body of experimentally infected mice]. 1978415454
[mechanism of the changes in the animal reactivity to tularemia in mixed infection].experiments were conducted on albino rats infected with listeria or salmonelloses, and then with tularemia; differences were revealed in the duration of manifestation of nonspecific resistance associated with peculiarities of pathogenesis and immunogenesis of the background infections. one of the significant factors causing an increase of albino rats resistance to tularemia in mixed infection was activation of the immunomorphological reaction promoting accelerated development of specific immunit ...1978415458
listeria monocytogenes and encephalitis. 1978415673
effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. comparative studies in normal and congenitally athymic (nude) mice.clinically, it is important to know whether agents used for immunostimulation require the presence of functional thymus-derived (t) cells. previous studies showed that both bcg and c. parvum induced a macrophage-dependent enhanced in vivo listeria clearance and in vivo inhibition of a fibrosarcoma induced by 20-methylcholanthrene. these two models were re-evaluated in congenitally thymusless (nude or nu/nu) b10lp mice lacking functional t cells. in nu/nu mice, (1) bcg failed to enhance listeria ...1977415917
proposals for quality control methods of bacterial vaccines for immunostimulation. iii. effect of bcg and c. parvum on in vivo listeria clearance and tumor growth.two quality control methods for bcg and c. parvum are described. first, in vivo macrophage dependent-spleen clearance of listeria monocytogenes in inbred b10lp mice. bcg and c. parvum were administered intravenously prior to listeria inoculation (a prophylactic model). conditions for enhanced listeria clearance including dose, route and time interval were described for each vaccine. next, a tumor model was developed: i.e. a fibrosarcoma, chemically induced by 20-methylcholanthrene in inbred balb ...1977415924
enhanced primary resistance to listeria monocytogenes in t cell-deprived mice. 1977415965
impaired chemotactic responsiveness of macrophages from gnotobiotic rats.peptone-induced macrophages obtained from gnotobiotic (gb) rats responded poorly to chemotactic stimuli that have a powerful, attractive influence upon the cells of conventional donors. monocyte recruitment from the circulation into peptone-induced exudates also was impaired in gb subjects. although relatively more resident cells are present in exudates borne by gb donors, their number cannot in itself account for the sluggish response of peptone-induced cells from gb rats. neutrophil accumulati ...1978415979
[case of abortion with positive serologic reaction and positive blood culture for listeria monocytogenes]. 1978416429
in vitro susceptibility of listeria monocytogenes to some antibiotics and their combinations.the listeria monocytogenes strains isolated during recent years in our hospital have been tested for in vitro susceptibility against eleven antibiotics. the following tests were used: antibiotics discs method on mueller-hinton agar, determination of mics by agar dilution method, study of the bactericidal potency of antibiotics combinations. antibiotic discs method gives some too optimistic results, not confirmed by the mics determined with agar dilution method. ther are a few antibiotics used al ...1978416625
listeria encephalitis in five renal transplant recipients.listeria encephalitis has occurred recently in 5 renal transplant recipients at the transplantation unit in stockholm. symptoms from the central nervous system, such as coma, hemiparesis and cranial nerve paresis, dominated the clinical picture. listeria monocytogenes was isolated from the blood of all the patients, from the cerebrospinal fluid in two, from the urine in one and post mortem from the brain in one patient. pleocytosis never exceeded 200 leucocytes/mm3 and the glucose ratio was norm ...1978416653
resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice.resistance and susceptibility to listeria monocytogenes in mice was found to be related to (i) the innate ability of the nonimmune macrophages to kill or inhibit the growth of the organism during the first 24 to 48 h after infection, and (ii) the time of onset of acquired cell-mediated resistance. resistant c57bl/6 mice were 10 times more efficient than susceptible balb/c mice at suppressing the early growth of listeria in the liver. furthermore, the onset of acquired immunity occurred 24 to 48 ...1978417029
development of listeria monocytogenes in monoxenic and polyxenic beef minces.the objective of this study was to determine the multiplication possibilities of listeria monocytogenes in beef minces with a defined microflora (gnotoxenic). selective counts were made for each species and each bacterial association for a period of 17 days after inoculation of the axenic meat. the concentration of l. monocytogenes did not increase, but remained constant in monoxenic meats. associated with lactobacillus plantarum, the number of listeria tended to decrease. conversely, in associa ...1978417516
[increased resistance in mice to listeria monocytogenes after treatment with a fraction from an inflammatory granuloma].the multiplication of listeria monocytogenes in the spleen was decreased between the 3rd and the 11th day following the inflammatory reaction induced in mice by subcutaneous implantation of talc embedded in a calcium phosphate gel into the dorsal area. a similar activity was observed after injection of so4 (nh4)2 fractionated extracts from granuloma. the major activities were found in the 33% saturation precipitate and in the 80% saturation supernatant.1977417840
three phases of phagocyte contribution to resistance against listeria monocytogenes. 1978418145
further characterization of listeria monocytogenes serotype 5.fifteen strains of listeria monocytogenes serotype 5 were characteriized for carbohydrate utilization, enzymic reactions, and other differential criteria. hemolytic patterns were tested on ovine, bovine, equine, human and lapine blood agars. results were compared with those of previously reported strains of l. monocytogens serotype 5.1978418861
outcome of listeria monocytogenes infection in compromised and non-compromised adults; a comparative study of seventy-two cases.the mortality in listeric meningitis and septicaemia, the two main clinical manifestations of the infection, is generally considered to be high. however, co-existing disorders rather than the listeric infection itself seem to determine the outcome. in the present study of 72 listeric infections among non-pregnant adults, 28 patients without co-existing disease had a fatality rate of 10.7% as compared to 57.9% among 19 immunocompromised individuals. finally, in a third group of listeric patients, ...1979437892
resistance to listeria monocytogenes in mice: genetic control by genes that are not linked to the h-2 complex.after mice of several inbred strains were injected with listeria monoyctogenes, two parameters of resistance, the 50% lethal dose and the suppression of bacterial proliferation in spleen, were determined. the strains of mice tested could be segregated into two groups: the resistant c57bl/10sn mice and the sensitive a/j and dba/2j mice. congenic resistant strains of mice were used because they would express the h-2 haplotype of the sensitive strains (h-2a or h-2d) on the background of a resistant ...1979438535
[listeria monocytogenes meningitis. report of 12 cases (author's transl)]. 1979471725
fish oil-induced yellow fat disease in rats. iv. functional studies of the reticuloendothelial system.in rats with "stage s/e" yellow fat disease an injection of colloidal carbon resulted in a marked reduction in the number of circulating platelets. the death rate of rats with experimental listeria monocytogenes infection, the number of bacteria in their spleens and the decrease of bacteria in their spleens on the days after infection were the same in rats with yellow fat disease as in controls. the fact that the rats died during the first few days after infection also may indicate that their im ...1979473490
[determination of the bactericidal activity of peritoneal macrophages: a new method (author's transl)].a new method to estimate the bactericidal activity of peritoneal macrophages is described. this method allows to calculate with great accuracy the number of phagocytised bacteria per macrophage. in serial experiments different degrees of activation of macrophages in respect to their bactericidal activity against listeria monocytogenes has been shown.1979478579
[case of l. monocytogenes meningitis in the non-neonatal period].a case of listeria monocytogenes meningitidis in a little girl of envie (cuneo) is reported. the epidemiologic study has shown the presence of significatively high antibodies titers also in the sera of other members of the family.1979488580
listeria pneumonitis: influence of route of immunization on resistance to airborne infection.mice that are immunized with an airborne inoculum of bcg are more highly resistant to airborne challenge with mycobacterium tuberculosis than are mice that are immunized by the subcutaneous or intravenous route. to discover whether this phenomenon is peculiar to tuberculosis, we studied the influence of the route of immunization upon pulmonary resistance in listeria monocytogenes infection. mice were immunized by the airborne, intravenous, or footpad route and were subsequently challenged by the ...1979489125
mechanisms of listeria monocytogenes-mediated modulation of tumor growth.studies using listeria monocytogenes as an antitumor agent were initiated to determine the requirements for listeria-mediated tumor inhibition to occur. when strain 13 guinea pigs were injected with an admixture of viable listeria and a methylcholanthrene-induced fibrosarcoma in a ratio of 1 bacterium to 100 tumor cells, listeria had a marked capacity to inhibit tumor growth. this confirms an earlier study in our laboratory (m. m. dustoor, a. fulton, w. croft, and a. a. blazkovec, infect. immun. ...1979489127
cns listeriosis: rhomboencephalitis in a healthy, immunocompetent person.a previously healthy woman had a febrile illness resembling aseptic meningoencephalitis. with the exception of mild increase in both csf pressure and protein concentration, initial findings were normal, including negative bacterial cultures. bilateral pyramidal and cerebellar signs with multiple lower cranial nerve pareses developed over a 48-hour period beginning on the tenth hospital day. repeated blood and csf studies had previously been nondiagnostic, but at that time, cultures became positi ...1979508167
infection of the brainstem by listeria monocytogenes.a case of brainstem infection by listeria monocytogenes is described. the patient was a 63 year old man previously in good health and his illness did not follow the usual bi-phasic pattern. there was no prodromal phase, and the progressive brainstem signs with a lymphocytosis and a normal sugar level in the csf led to a tentative diagnosis of viral brainstem encephalitis. ampicillin was begun only when signs of pulmonary infection developed. clinical diagnosis is difficult but ampicillin should ...1979512667
simultaneous listeria monocytogenes septicaemia in mother and pre-term infant. 1979523369
mouse strain difference in the protection against listeria monocytogenes. 1979527919
evaluation of gentamicin and penicillin as a synergistic combination in experimental murine listeriosis.the administration of a combination of penicillin and gentamicin to mice given an intraperitoneal challenge of a highly pathogenic strain of listeria monocytogenes resulted in increased survival as compared with groups receiving penicillin alone or gentamicin alone or a control group that received no antibiotic. the median survival of animals that eventually died was no longer than in groups receiving single antibiotics and suggests that additional studies should be carried out to further invest ...1979533266
[bacterial meningitis in newborn infants. a retrospective study from a pediatric clinic 1967-1978].a total of 22 newborn infants (14 boys, 8 girls) have been admitted and treated for bacterial meningitis in the university pediatric service of geneva over a period of 11 years (may 1967 to may 1978). the three most common infectious agents were: group b beta-hemolytic streptococcus (6/22 cases), escherichia coli (6/22 cases), and listeria monocytogenes (4/22 cases). thirteen of the 22 infants died (a 59% mortality, in keeping with that observed in other centers). follow-up of the nine survivors ...1979541219
[infectious listeria monocytogenes endocarditis. apropos of a case]. 1979543809
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