Publications

rate of cultivable subgingival periodontopathogenic bacteria in chronic periodontitis.	although microbiological studies have identified more than 400 bacterial species in periodontal pockets, only a limited number have been implicated as periodontal pathogens. the purpose of this study was to investigate the incidence of cultivable subgingival periodontopathogenic bacteria in chronic periodontitis. bacterial samples were collected with sterile paper points from the deepest periodontal pockets ((5 mm) of 203 patients: 92 males and 111 females, aged 35-55 years. the samples were cul ...	2004	15508748
molecular identification of an invasive gingival bacterial community.	a woman with neutropenia developed gingival hyperplasia. biopsy showed invasion of gingival tissue with mats of filamentous organisms, and molecular analysis by polymerase chain reaction and fluorescence in situ hybridization revealed capnocytophaga sputigena, leptotrichia species, and fusobacterium nucleatum. oral bacterial flora may cause invasive gingival disease with hyperplasia in immunocompromised patients.	2005	15937752
chromosome- and plasmid-encoded beta-lactamases in capnocytophaga spp.	chromosome- and plasmid-encoded cfxa2 and cfxa3 beta-lactamases were detected in capnocytophaga spp. from oral sources in france, norway, and the united states. unidentified chromosome-encoded beta-lactamases were present in capnocytophaga sputigena. nucleotide sequence analysis of the cfxa3-encoding plasmid from c. ochracea revealed an unreported insertion sequence (iscoc1) upstream of the cfxa gene.	2005	16127077
distribution of 10 periodontal bacteria in saliva samples from japanese children and their mothers.	we analyzed the distribution of 10 periodontal bacteria species (porphyromonas gingivalis, tannerella forsythensis, prevotella intermedia, prevotella nigrescens, campylobacter rectus, eikenella corrodens, actinobacillus actinomycetemcomitans, capnocytophaga ochracea, capnocytophaga sputigena, and treponema denticola) in children, and then compared their distribution in those children and their mothers, with special attention given to three of the species known as the red complex (p. gingivalis, ...	2006	16269128
infection at titanium implants with or without a clinical diagnosis of inflammation.	to assess the microbiota at implants diagnosed with peri-implantitis, implant mucositis, or being clinically healthy.	2007	17517058
diversity of capnocytophaga species in children and description of capnocytophaga leadbetteri sp. nov. and capnocytophaga genospecies ahn8471.	bacteria of the genus capnocytophaga form part of the resident oral flora in children and adults. they are recognized as opportunistic pathogens of various extra-oral infections. the significance of individual species in periodontal and extra-oral diseases is unclear, due to the inability of conventional phenotypic tests to identify clinical isolates to species level. aiming at a clear distinction between species, we undertook a phylogenetic study of a collection of 102 capnocytophaga strains in ...	2008	18218926
clinical and microbiological analysis of subjects treated with brånemark or astratech implants: a 7-year follow-up study.	to assess the impact of different implant systems on the clinical conditions and the microbiota at implants, and whether the presence of bacteria at tooth sites was predictive of the presence at implant sites.	2008	18261121
[septicaemia with capnocytophaga sputigena in a newborn child].	we describe in this article a case of septicaemia with capnocytophaga suptigena in a premature newborn child. the newborn child exhibited fever at birth, a light inflammatory syndrome and a respiratory failure. the germ was initially identified in the blood-culture of the newborn child by conventional techniques, and then confirmed by sequencing of the arn 16s. after investigation, it was also found in the mother's vaginal sample. capnocytophaga sputigena carried by the mother is certainly respo ...	2008	18390433
microbiological evaluation of primary endodontic infections in teeth with and without sinus tract.	to examine the microbiological status of primary endodontic infections in teeth with and without a sinus tract.	2008	18422583
first case of bacteremia due to chromosome-encoded cfxa3-beta-lactamase-producing capnocytophaga sputigena in a pediatric patient with acute erythroblastic leukemia.	bacteremia due to capnocytophaga sputigena occurred in a 4-year and 9-month-old japanese girl patient with acute erythroblastic leukemia in shinshu university hospital, japan. on her admission to the hospital, she had a temperature of 38.2 degrees c with canker sore. prior to the commencement of chemotherapy, peripheral blood culture was carried out with the bact/alert 3d system ver. 4.00d (biomerieux japan ltd., tokyo, japan) using both the pf and the sn bottles. at 48 hrs of incubation, the sy ...	2008	18499560
[capnocytophaga sputigena pleuropneumonitis: a case report].	community-acquired pneumonia is complicated by purulent pleural effusion in approximately 28% of affected children. its incidence has increased over the last decade. streptococcus pneumoniae is the most frequent causal microorganism, encountered in roughly 80% of cases. we report the case of an immunocompetent 13-year-old teenager wearing orthodontic braces who suffered from pleuropneumonia due to capnocytophaga sputigena. to date, this gram-negative bacillus, a commensal of the buccal cavity, h ...	2008	18804973
microbiological findings in subjects with asymptomatic oral lichen planus: a cross-sectional comparative study.	the bacterial colonization of the oral mucosa was evaluated in patients with asymptomatic oral lichen planus (olp) and compared to the microbiologic status in mucosally healthy subjects.	2008	19053926
does pregnancy have an impact on the subgingival microbiota?	we investigated clinical and subgingival microbiologic changes during pregnancy in 20 consecutive pregnant women > or =18 years not receiving dental care.	2009	19228092
comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray.	this study compared the subgingival microbiota of subjects with refractory periodontitis (rp) to those in subjects with treatable periodontitis (grs = good responders) or periodontal health (ph) using the human oral microbe identification microarray (homim).	2009	19722792
distribution of periodontopathic bacterial species in japanese children with developmental disabilities.	recent developments in molecular biological techniques have enabled rapid detection of periodontopathic bacterial species in clinical specimens. accumulated evidence suggests that detection of specific bacterial species enables identification of subjects at high risk for the onset of periodontitis. we investigated the distribution of 10 selected periodontopathic bacterial species in dental plaque specimens obtained from children with disabilities who were attending daycare centers.	2009	19772671
characterization of csp-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of capnocytophaga sputigena.	the capnocytophaga sputigena isolate nor, responsible for septicemia, was resistant to amoxicillin and narrow-spectrum cephalosporins. in a cloning experiment, a new gene, bla(csp-1), was identified; this gene encodes a novel extended-spectrum beta-lactamase (esbl) that shares only 52% and 49% identities with the cme-1 and veb-1 beta-lactamases, respectively. the g+c content of this gene, its genetic environment, the absence of conjugation transfer, and its detection in two reference strains sug ...	2010	20308380
capnocytophaga sputigena primary iliopsoas abscess.	iliopsoas abscess is usually secondary to the spread of infection from a contiguous focus. primary disease is uncommon, except in children where staphylococcus aureus is the main pathogen. we report a 60-year-old woman who developed a primary iliopsoas abscess as a result of haematogenous spread of capnocytophaga sputigena from a palatal fistula and chronic sinusitis due to previous treatment for nasopharyngeal carcinoma. pyomyositis due to unusual and fastidious gram-negative bacilli should be ...	2010	20634330
il6 -174 genotype associated with aggregatibacter actinomycetemcomitans in indians.	genetic factors have recently been associated with presence of aggregatibacter actinomycetemcomitans subgingivally in populations living in industrialized countries. the aim of this study was to analyse associations between interleukin-6 (il6) single nucleotide polymorphisms and presence and levels of a. actinomycetemcomitans and other subgingival microbes in a rural indian population.	2011	20860759
evaluation of the subgingival microbiota of alcoholic and non-alcoholic individuals.	the aim of this study was to evaluate the composition of the subgingival microbiota of alcoholic and non-alcoholic individuals.	2011	21864643
Early microbial succession in redeveloping dental biofilms in periodontal health and disease.	Teles FR, Teles RP, Uzel NG, Song XQ, Torresyap G, Socransky SS, Haffajee AD. Early microbial succession in redeveloping dental biofilms in periodontal health and disease. J Periodont Res 2011; doi: 10.1111/j.1600-0765.2011.01409.x. © 2011 John Wiley & Sons A/S Background and Objective: The development of dental biofilms after professional plaque removal is very rapid. However, it is not clear whether most bacterial species return at similar rates in periodontally healthy and periodontitis subj ...	2011	21895662
molecular detection of human periodontal pathogens in oral swab specimens from dogs in japan.	periodontal diseases are known to be major diseases in humans, and are also common in dogs. the purpose of the present study was to analyze the distribution of periodontitis-related bacterial species using oral swab specimens collected from 26 pet dogs. the distribution of an animal gingival organism porphyromonas gulae, in addition to 10 human periodontitis-related bacterial species, including porphyromonas gingivalis, treponema denticola, tannerella forsythia, capnocytophaga ochracea, capnocyt ...	2011	21916371
investigation of six selected bacterial species in endo-periodontal lesions.	didilescu ac, rusu d, anghel a, nica l, iliescu a, greabu m, bancescu g, stratul si. investigation of six selected bacterial species in endo-periodontal lesions. international endodontic journal, 45, 282-293, 2012. abstract: aim to investigate and determine possible associations of six tested bacteria belonging to 'orange' and 'green' complexes, in endo-periodontal lesions: parvimonas micra, fusobacterium nucleatum, campylobacter rectus, eubacterium nodatum, eikenella corrodens and capnocytopha ...	2011	22077868
impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray.	this study compares the changes to the subgingival microbiota of individuals with "refractory" periodontitis (rp) or treatable periodontitis (good responders [gr]) before and after periodontal therapy by using the human oral microbe identification microarray (homim) analysis.	2012	22324467
distribution of periodontopathic bacterial species in dogs and their owners.	presently, a large number of individuals consider their companion animals as family members and have close contact with them in daily life. the purpose of the present study was to analyze the distribution of periodontopathic bacterial species in oral specimens taken from dogs and their owners.	2012	22417880
capnocytophaga species and perinatal infections: case report and review of the literature.	capnocytophaga species are part of the normal human oral bacterial flora.they are recognized as opportunistic pathogens leading to various extra-oral infections including septicemia, osteomyelitis, abscesses and keratitis and they have been rarely reported as a cause of chorioamionitis and neonatal infection. we here report the first two cases of chorioamionitis produced by capnocytophaga sputigena and the recently described c. leadbetteri in belgium. both isolates were correctly identified at t ...	2016	22480039
[fatal bacteremia related to capnocytophaga sputigena in a hematological patient with type t non-hodgkin lymphoma. diagnosis by 16s rrna gene sequencing].	we described a case of fatal bacteremia related to capnocytophaga sputigena in a hematological patient. the strain was identified by 16s rrna gene sequencing.	2015	23102464
capnocytophaga sputigena empyema.	empyema is a problem faced by clinicians worldwide. most cases are caused by gram-positive organisms, such as streptococci and staphylococci. empyema caused by capnocytophaga spp. is extremely uncommon (h. bonatti et al., clin. microbiol. infect. 9:380-387, 2003). we present a unique case of a polymicrobial empyema, with a predominance of capnocytophaga sputigena, in an older patient with no history of animal bite or splenectomy.	2013	23698526
the cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity.	coeliac disease is characterized by intestinal inflammation caused by gluten, proteins which are widely contained in the western diet. mammalian digestive enzymes are only partly capable of cleaving gluten, and fragments remain that induce toxic responses in patients with coeliac disease. we found that the oral microbiome is a novel and rich source of gluten-degrading organisms. here we report on the isolation and characterization of the cultivable resident oral microbes that are capable of clea ...	2013	23714165
high prevalence of β-lactam and macrolide resistance genes in human oral capnocytophaga species.	to determine macrolide-lincosamide-streptogramin (mls) resistance determinants in the capnocytophaga genus and to describe the prevalence of β-lactam resistance genes in human oral capnocytophaga species.	2014	24013195
phototargeting human periodontal pathogens in vivo.	the effects of blue light at 455 nm were investigated on the bacterial composition of human dental plaque in vivo. eleven subjects who refrained from brushing for 3 days before and during phototherapy participated in the study. light with a power density of 70 mw/cm(2) was applied to the buccal surfaces of premolar and molar teeth on one side of the mouth twice daily for 2 min over a period of 4 days. dental plaque was harvested at baseline and again at the end of 4 days from eight posterior tee ...	2015	24346334
16s rdna-based metagenomic analysis of dental plaque and lung bacteria in patients with severe acute exacerbations of chronic obstructive pulmonary disease.	acute exacerbations of chronic obstructive pulmonary disease (ae-copd) are leading causes of mortality in hospital intensive care units. we sought to determine whether dental plaque biofilms might harbor pathogenic bacteria that can eventually cause lung infections in patients with severe ae-copd.	2014	24484531
microbial diversity in persistent root canal infections investigated by checkerboard dna-dna hybridization.	the aim of the present study was to investigate the composition of the root canal microbiota in endodontic failures in order to identify and quantify these microorganisms.	2014	24935532
capnocytophaga sputigena bacteremia in a patient with chronic lymphocytic leukemia.		2014	24982840
influence of the periodontal status on the initial-biofilm formation on titanium surfaces.	dental implants will be exposed to a complex ecosystem once they are placed in the oral cavity. the bacterial colonization and biofilm formation on these devices will depend not only on the physicochemical surface implant properties but also on the periodontal health conditions of the patients, as these devices are exposed.	2016	24995517
quantitative molecular detection of 19 major pathogens in the interdental biofilm of periodontally healthy young adults.	in oral health, the interdental spaces are a real ecological niche for which the body has few or no alternative defenses and where the traditional daily methods for control by disrupting biofilm are not adequate. the interdental spaces are the source of many hypotheses regarding their potential associations with and/or causes of cardiovascular disease, diabetes, chronic kidney disease, degenerative disease, and depression. this pcr study is the first to describe the interdental microbiota in hea ...	2016	27313576
metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium capnocytophaga sputigena.	the association between exposure to smokeless tobacco products (stp) and oral diseases is partially due to the physiological and pathological changes in the composition of the oral microbiome and its metabolic profile. however, it is not clear how stps affect the physiology and ecology of oral microbiota. a uplc/qtof-ms-based metabolomics study was employed to analyze metabolic alterations in oral bacterium, capnocytophaga sputigena as a result of smokeless tobacco exposure and to assess the cap ...	2016	27480511
benefits of bifidobacterium animalis subsp. lactis probiotic in experimental periodontitis.	this study evaluates effects of topical administration of probiotic bacteria of the genus bifidobacterium on experimental periodontitis (ep) in rats.	2017	27660886