Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [the intragastral antibacterial effect and its importance in chronic enterocolitis]. | 1978 | 31275 | |
| the neurochemistry of learning and memory. | the neurochemical basis of memory has been approached experimentally in four different ways: the bioassay; the interventive approach; the interventive-correlative approach; and the correlative approach. these approaches are fundamentally similar to those used for the study of the chemistry of any behavior. each of these approaches has serious limitations, and significant progress has only been made by combinations of more than one. i shall discuss each of these approaches in turn. | 2001 | 31280 |
| cardiac lesions induced by chemicals. | chemically induced cardiomyopathies are frequently the consequences of a cardiac metabolic imbalance brought about by exaggerated functional affects. the infarctlike lesions induced by adrenergic beta-receptor stimulants and the vasodilating antihypertensives serve as examples of this phenomenon. direct cardiotoxic mechanisms not related to cardiovascular functional effects are responsible for another class of toxic cardiomyopathy. an example of this is the cardiomyopathy produced by the anthrac ... | 2001 | 31282 |
| facilitation of transmitter release at squid synapses. | facilitation is shown to decay as a compound exponential with two time constants (t1, t2) at both giant and non-giant synapses in squid stellate ganglia bathed in solutions having low extracellular calcium concentrations ([ca++]o). maximum values of facilitation (f1) were significantly larger, and t1 was significantly smaller in giant than non-giant synapses. decreases in [ca++]o or increases in [mn++]o had variable effects on t1 and f1, whereas decreases in temperature increased t1 but had insi ... | 2001 | 31411 |
| (exo, exo)-2-aryltropane-3-carboxylic esters, hypoglycemic agents with accompanying analgesic activity. | (exo, exo)-2-aryltropane-3-carboxylic esters of types 6, 7, and 10 lower circulating blood glucose levels by 60--80%. this activity is accompanied by an analgesic activity roughly equal to that of codeine. both of these activities reside in the 1r enantiomer and extensive structure-activity studies failed to separate them. the specific opioid antagonist nalorphine blocks the analgesic activity but does not diminish the hypoglycemic action. conformational integrity afforded by the ethylene bridge ... | 1978 | 31482 |
| [the efficacy of a maintenance dose of 100 mg doxycycline (vibramycin) daily in bacterial infections of chronic bronchitis (author's transl)]. | the efficacy and tolerance of a daily maintenance dose of 100 mg doxycycline (vibramycin) was investigated in ambulant patients with chronic obstructive pulmonary disease (copd) and bacterial infection by an open study with clinical, bacteriological and cytological control. the dosage was well tolerated and effective in the elimination of h. influenzae and pneumococci. a higher maintenance dose seems not to be necessary for this type of infections. | 1978 | 31554 |
| [treatment of chronic bronchitis with supristol and a cotrimoxazole preparation--comparative bacteriological and clinical findings, results of a double-blind study (author's transl)]. | in a randomized double-blind study on the treatment of chronic bronchitis, supristol (co-trifamole) was compared with co-trimoxazole. 163 patients participated in the clinical trial that was performed at three different hospitals in accordance with a uniform trial plan. the microbiological investigations were done centrally at a hygiene institute for all three hospitals. the bacteriological results from the 61 patients whose antibiogram revealed sensitive pathogens before starting the therapy de ... | 1978 | 31555 |
| [findings of biochemical research on schizophrenia (author's transl)]. | 1998 | 31575 | |
| [a case of lumbosacral myelomeningocele--infected shunt system and the treatment (author's transl)]. | 1998 | 31576 | |
| self-poisoning in auckland reconsidered. | data is presented describing 345 self-poisoners presenting at the accident and emergency department and 211 referred to the psychiatric liaison service at auckland hospital during the 12 month period between august 1976 and july 1977. both groups show the age and sex distribution commonly seen in self-poisoning, with a preponderance of young females. referral rates increased with age and with the implication of anti-depressants, neuroleptics and anticonvulsants. only 20 percent of the referred p ... | 2001 | 31581 |
| the use of bacteria for the functional characterization of human lymphocyte subpopulations in various lymphoid organs. | in a haemolytic plaque assay staphylococcal strain cowan 1 was shown to induce polyclonal antibody secretion in human blood lymphocytes, whereas haemophilus influenzae and escherichia coli gave low responses. diplococcus pneumoniae and haemolytic streptococci generally did not activate blood cells. all five bacteria could activate spleen, tonsil and adenoid cells both to polyclonal ig secretion and increased dna synthesis. thus blood cell reactivity does not necessarily reflect the response patt ... | 1978 | 31677 |
| serological methods for rapid diagnosis of haemophilus influenzae, neisseria meningitidis and streptococcus pneumoniae in cerebrospinal fluid: a comparison of co-agglutination, immunofluorescence and immunoelectroosmophoresis. | 1978 | 31678 | |
| hr 756, the syn isomer of a new methoxyimino cephalosporin with unusual antibacterial activity. | hr 756, the syn derivative of 7-[(2-(2-amino-4-thiazolyl)-2-methoxyimino)acetamido]cephalosporanic acid, is a new semisynthetic cephalosporin. it was 80 times more active than the anti derivative against beta-lactamase-producing strains of gram-negative bacteria. the range of inhibitory concentrations of hr 756 against gram-negative bacteria, including haemophilus influenzae, susceptible or resistant to penicillins and cephalosporins was from 0.01 to 0.1 mug/ml. this activity was consistently hi ... | 1978 | 31836 |
| metabolic activation of 2,4-diaminoanisole, a hair-dye component--ii. role of cytochrome p-450 metabolism in irreversible binding in vitro. | 1979 | 31890 | |
| [bacterial allergy in asthmatic syndromes]. | 1976 | 31959 | |
| prospects for the prevention of bacterial meningitis with polysaccharide vaccines. | most suppurative infections of the meninges are caused by five bacterial species: escherichia coli, haemophilus influenzae type b, streptococcus pneumoniae, neisseria meningitidis, and group b streptococcus. the immune response of adults to pneumococcal capsular polysaccharides has been studied in great detail and their responses to meningococcal and h. influenzae type b capsular polysaccharides are quite similar. immune responses of adults to e. coli and group b streptococcal antigens are disap ... | 1978 | 31985 |
| [a longitudinal study on the eeg abnormalities in schizophrenic patients treated with neuroleptics (author's transl)]. | 1999 | 32126 | |
| adverse effects in maintenance therapy. | adverse effects in maintenance therapy with neuroleptic drugs and lithium salts were reviewed with special emphasis on tardive dyskinesia. the possible teratogenicity of neuroleptics and lithium salts was discussed and the chromosomal abnormalities seen in patients treated with lithium salts described. | 1999 | 32148 |
| twice daily dosage of bacampicillin in chronic bronchitis. a double-blind study. | three groups of patients (total 48) with acute exacerbations of chronic bronchitis were treated orally for 10 days, in a double-blind clinical trial, with bacampicillin (an ampicillin ester) 1600 mg twice daily, 800 mg three times daily and oral ampicillin 1000 mg three times daily. most exacerbations were caused by haemophilus influenzae or streptococcus pneumoniae. clinical and bacteriological results were significantly more favourable in the two bacampicillin-treated groups. both drugs were g ... | 1978 | 32615 |
| purification and properties of a new restriction endonuclease from haemophilus influenzae rf. | haemophilus influenzae rf 232, showing the phenomena of restriction and modification, contains an endonuclease that inactivates in vitro the biological activity of dnas lacking the strain-specific modification. this specific restriction endonuclease has been purified to near homogeneity by a procedure that includes dna-agarose chromatography. this highly purified enzyme requires atp and mg2+ for activity and is stimulated by s-adenosylmethionine. the enzyme seems to cleave dna at well-defined si ... | 1978 | 33045 |
| analysis of cysteinyldopas, dopa, dopamine, noradrenaline and adrenaline in serum and urine using high-performance liquid chromatography and electrochemical detection. | the catecholic amino acids, dopa, 2-s- and 5-s-cysteinyldopa, and 2,5-s,s-dicysteinyldopa were determined qualitatively in serum from patients with malignant melanoma by reversed-phase high-performance liquid chromatography, using electrochemical detection. in urine the catecholamines dopamine, noradrenaline and adrenaline were also determined qualitatively, as well as the above-mentioned compounds, in a single chromatographic run. the conditions were optimized by changing the ph of the mobile p ... | 2001 | 33194 |
| opportunist lung infections. | 1979 | 33268 | |
| [bacterial polysaccharides--a new generation of vaccines]. | 1979 | 33301 | |
| kinetic studies in isolated organs: tools to design analgesic peptides and to analyze their receptor effects. | the opioid activities of peptide and non-peptide narcotics were studied in longitudinal muscle strip of guinea pig ileum (gpi) and in mouse vas deferens (mvd). the comparison of agonist activities of peptides found in gpi and mvd offered the opportunity to predict the presence but not the magnitude of potential analgesic activity. the kinetics of the antagonism between naltrexone and different types of agonists were also determined in these systems. using c-6 epimers of naltrexone, it was found ... | 1979 | 33396 |
| counterimmunoelectrophoresis of sputum and blood for the diagnosis of chest infections caused by pneumococci or haemophilus influenzae. | in 107 patients with lower respiratory tract infections, counterimmunoelectrophoresis (cie) of blood and sputum, bacterial cultures of blood, sputum and nasopharyngeal secretion, and enzyme-linked immunosorbent assay (elisa) for antibody determination were performed, with special reference to pneumococci and haemophilus influenzae. for pneumococci cie of sputum was superior to culture especially in antibiotic-treated patients. the clinical significance of a positive cie of sputum was supported b ... | 1979 | 33446 |
| effect of growth conditions on the antigenic components of streptococcus mutans and lactobacilli. | 1) the release of lta from chemostat-grown cultures of s. mutans and l. fermentum is dependent on the generation time and ph. 2) the growth rate affects the immunogenicity of lta and the wall polysaccharide of l. fermentum. 3) the growth of l. plantarum under glucose limitation influences the glucose content of the wall teichoic acid. the composition of the wall polysaccharide of s. mutans ingbritt may also be changed under these conditions. 4) the conditions of autoclaving used to release cell ... | 1978 | 33543 |
| solubility of doxycycline in aqueous solution. | the solubility of doxycyline monohydrate and doxycycline hydrochloride dihydrate was investigated in aqueous solution. the hydrochloride dihydrate salt was isolated and identified from solutions initially containing doxycycline hyclate in water. the pka' = 3.09 (mu = 0.1 and 25 degrees) for protonation of doxycycline was determined spectrophotometrically. the ph-solubility profiles were determined for doxycycline monohydrate in water and in 1.0 m nano3-hno3 and nacl-hcl. the ph-solubility profil ... | 2000 | 34018 |
| a search for causes of polymorphism in clithon oualaniensis (lesson) (gastropoda; prosobranchia). | western clithon from india and ceylon differs from eastern clithon from the malay peninsula and hong kong as regards shell pattern and coloration (grüneberg 1976, 1978). the western form lives in regions with high surface salinity whereas the eastern form lives in regions with low surface salinity. this situation may either reflect a causal relation, or it may be the result of a coincidence. the evidence presented in this paper speaks against a causal relation and suggests that other factors wit ... | 1997 | 34160 |
| diagnosis and treatment: drugs five years later. amoxicillin. | amoxicillin is an aminopenicillin available in the united states only for oral use. it has an antibacterial activity and spectrum similar to that of ampicillin and is destroyed by gram-positive and gram-negative beta-lactamases. it is more active against enterococci and salmonellae than ampicillin, but less active against shigella. it is better absorbed than ampicillin from the gastrointestinal tract with blood levels two to two and one half times those of ampicillin. amoxicillin is an excellent ... | 1979 | 34342 |
| [phenomenon of parental resistance and its genetic regulation]. | lymphocytes of mice f1 (cba x m523) and f1 (a x m523) transplanted to 1000 r irradiated cba or a mice responded to the test antigens--srbc or s. typhi vi-antigen--by formation of 100--1000 times less antibody forming cells than in syngeneic recipients. an intermediate result is achieved when the lymphoid cells are transplanted to the irradiated m523 mice. lymphocytes of mice f1 (a x cba), f1 (cba x c57bl/6), or f1 (a x a.ca) developed a similar immune response in the irradiated syngeneic mice an ... | 1979 | 34452 |
| studies on the structure-activity relationship of adrenergic beta-mimetic benzylamine derivatives. iv.1) aryl-substituted 1-aminotetralins and 1-aminoindans. | 1978 | 34486 | |
| [comparative sensitivities of six different species of mosquitoes to bacillus thuringiensis var. israelensis]. | 1979 | 34488 | |
| comparison of staphylococcal coagglutination, latex agglutination, and counterimmunoelectrophoresis for bacterial antigen detection. | soluble antigens of haemophilus influenzae type b, streptococcus pneumoniae, neisseria meningitidis, and group b streptococcus were looked for in cerebrospinal fluid, serum, and urine by using the staphylococcal coagglutination test, latex agglutination test, and counterimmunoelectrophoresis. the staphylococcal coaggultination and latex agglutination tests were more sensitive than counterimmunoelectrophoresis in identifying antigens of h. influenzae type b, s. pneumoniae, and n. meningitidis. no ... | 1979 | 34622 |
| evaluation of blood culture procedures in a pediatric hospital. | to determine optimal clinical laboratory techniques for detecting pediatric bacteremia, we studied 7,768 consecutive blood cultures in a 1-year period. blood was inoculated into one vented 50-ml bottle of brucella broth with 0.05% sodium polyanetholsulfonate and one unvented 50-ml bottle of columbia broth with 0.05% sodium polyanetholsulfonate and 0.05% cysteine. bottles were visually examined for growth on days 1 through 7 and blindly subcultured aerobically and anaerobically on days 1, 2, and ... | 1979 | 34623 |
| chromogenic cephalosporin spot test to detect beta-lactamase in clinically significant bacteria. | lactamase production. reacteroides melaniongenicus, 14 | 1979 | 34624 |
| the nasopharyngeal culture in acute otitis media. a reappraisal of its usefulness. | simultaneous cultures of the nasopharynx and middle ear exudate (obtained by tympanocentesis) were obtained from 225 children (mean age, 34 months; median age, 41 months) with suppurative otitis media. a 72% prediction rate for middle ear pathogens was obtained by examining the nasopharyngeal cultures after the strict observance of two essential prerequisites: (1) the nasopharyngeal culture was immediately plated on appropriate solid agar and (2) a semiquantitative method for bacterial enumerati ... | 1979 | 34739 |
| [rolitetracycline in lung and biliary tract infections]. | 1979 | 34790 | |
| [modern data on the antibiotic sensitivity of the microflora that is an etiological factor in ent diseases. ii. the antibiotic sensitivity of pneumococci, meningococci, influenza bacilli, klebsiella, enterobacteria, pseudomonas aeruginosa and proteus]. | 1979 | 34945 | |
| the new peptide hormones of the gut and their clinical significance. | 1998 | 34965 | |
| k+ deprivation potentiates the renal acid excretory effect of mineralocorticoid: obliteration by amiloride. | 1979 | 35009 | |
| international conference on new developments in immunoassays. düsseldorf, november 14-15, 1977, and chicago, ill., december 5-6, 1977: proceedings. | 1998 | 35095 | |
| etiology and antimicrobial therapy of acute maxillary sinusitis. | eighty-one adults with symptoms of acute sinusitis were studied by direct needle puncture and aspiration of the maxillary sinus (105 sinuses). fifty-nine bacterial strains were isolated in titers of greater than or equal to 10(4) colony-forming units/ml; streptococcus pneumoniae and haemophilus influenzae accounted for 64% of the isolates. other bacteria recovered included anaerobes (12%), neisseria species (8.5%). streptococcus pyogenes (3%), alpha-hemolytic streptococcus (3%), non-group a beta ... | 1979 | 35571 |
| [treatment of bacterial meningitis with cefamandole]. | 1978 | 35821 | |
| otitis media in children: a prospective study of aerobic and anaerobic bacteriology. | tympanocentesis with aerobic and anaerobic cultivation of middle ear fluid was performed through one or both tympanic membranes of 186 children with acute otitis media. aerobic bacteria alone, predominantly pneumococcus and hemophilus influenzae, were isolated from 118 (63.4%) patients: and anaerobic organisms alone, most commonly peptococcus, from 24 (12.9%). twenty-six (14%) yielded mixtures of aerobes and anaerobes, and several had multiple aerobic agents. no bacterial growth was noted in 18 ... | 1979 | 36523 |
| the microbiology of serous and mucoid otitis media. | one hundred forty-four serous and mucoid effusions were cultured for aerobic bacteria, mycoplasma pneumoniae, and virus. thirty percent of all effusions yielded an unequivocally positive culture for aerobic bacteria. although serous effusions were culture positive as often as mucoid effusions, haemophilus influenzae was isolated predominantly from serous effusions and staphylococcus epidermidis predominantly from mucoid samples. only one of 73 effusions yielded a viral isolate (herpesvirus homin ... | 1979 | 36591 |
| otitis media with effusion. cytological and microbiological correlates. | a quantitative cytologic study of 83 middle ear effusions from children with otitis media with effusion (ome) was made with the use of cytocentrifuge-prepared smears and was correlated with bacteriological findings. the identification of the types of cell present in an effusion was confirmed by electron microscopic findings. the most common cell types were neutrophilic leukocytes, lymphocytes, and macrophages, but a few eosinophils were found in only one case. the cytologic profile of an effusio ... | 1979 | 36875 |
| cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use. | cefuroxime is a new semisynthetic cephalosporin for parenteral administration. it is resistant to destruction by beta-lactamases produced by staphylococci and most gram-negative aerobic bacteria and is active against many bacteria resistant to cephalothin. cefuroxime is the most active of the cephalosporins against gonococci and haemophilus influenzae particularly against beta-lactamase producing strains. given by intramuscular or intravenous injection cefuroxime is effective against a wide vari ... | 1979 | 37064 |
| cellulitis of the face caused by hemophilus influenzae during childhood. | 1979 | 37202 | |
| upper respiratory tract spread of group b streptococci type i b in a kindergarten. | in a kindergarten with 42 children and 17 female staff members, an epidemic of group b streptococcal carriage in the upper respiratory tract occurred. in the middle of february 1978, 6 children and 5 adults carried type i b streptococci in the throat while only 2 of these 11 were carriers 2 weeks later. only one other streptococcus, belonging to type ii, was found in the throat specimens. five strains other than type i b were found in the urogenital tract of the staff. three type i b throat carr ... | 1979 | 37592 |
| bactericidal action of an average dose of erythromycin in the bronchi. | a study was carried out to establish whether erythromycin stearate was bacteriostatic or bactericidal at the concentrations reached in the bronchial secretion. twenty-two patients suffering from an acute attack of chronic bronchitis, sustained by streptococci, diplococci, staphylococci or h. influenzae sensitive to erythromycin, were treated with 1500 mg erythromycin per day until symptoms regressed, usually within 3 to 5 days. the results showed that after treatment there was a dramatic reducti ... | 1979 | 38063 |
| report of iabs committee on avian product standardization. | the international association of biological standardization (iabs) organized an international symposium in august 1973 on the "requirements for poultry virus vaccines" at lyon (france). the proceedings of this symposium were subsequently published as "developments in biological standardization", volume 25. at the conclusion of this symposium, it was resolved that an avian biological products standardization committee should be established, this committee including four subcommittees, each under ... | 1978 | 38158 |
| abstracts of papers presented at the 1978 kyushu regional scientific meeting of the japanese society of electron micros copy held at yamaguchi university, dec. 9--10, 1978. | 1996 | 38294 | |
| the study of magnesium supplement to stored blood for the preservation of 2,3-diphosphoglycerate in red cells. | 1996 | 38373 | |
| pharmacokinetics and tolerability of a single oral 600-mg dose of doxycycline. | the pharmacokinetics of a single orally administered 600-mg dose of doxycycline (six 100-mg film-coated tablets) was studied in 18 healthy subjects. plasma doxycycline levels remained above 1.35 mumol/l for 48 hours and compared favourably with the mean inhibitory concentrations of doxycycline against the common infecting organisms in chronic bronchitis. in a separate tolerability study in 37 healthy subjects, there was no significant difference between doxycycline and placebo in the incidence o ... | 1979 | 38382 |
| detection of experimental bacteremia and fungemia by examination of buffy coat prepared by a micromethod. | rabbits received intravenous injections of bacteria or fungi, and a comparison was made of the abilities of broth cultures, plating after dilution either in saline solution or in distilled water containing triton x-100, and buffy coat examinations to detect the organisms in heart blood. the most sensitive method was broth culture. by microscopy or subculture of buffy coat cells prepared by centrifugation of blood in microhematocrit tubes, organisms were rapidly and regularly detected when their ... | 1979 | 38662 |
| bactericidal and bacteriostatic action of chloramphenicol against memingeal pathogens. | the bacteriostatic and bactericidal effects of chloramphenicol, ampicillin, tetracycline, and sulfisoxazole were compared against several potential meningeal pathogens. chloramphenicol is bactericidal at clinically achievable concentrations against haemophilus influenzae, streptococcus pneumoniae, and neisseria meningitidis. it is bacteriostatic against gram-negative bacilli of the family enterobacteriaceae and against staphylococcus aureus. chloramphenicol has proven highly efficacious in the t ... | 1979 | 38742 |
| [antibiotics therapy in chronic bronchitis]. | in chronic bronchitis antibiotic therapy is no causative therapy, because infection rarely is the beginning but the complication of an already existing airway disease. while sputum cultures are very limited in their value, blind chemotherapy of bacterial infections by substances like tetracycline, ampicilline, azidocilline or cotrimoxazole is allowed. in cases of additional obstruction a combination with corticosteroids sometimes may be useful. | 1979 | 39882 |
| use and efficacy of pneumococcal vaccine in patients with hodgkin disease. | fulminant bacterial sepsis has been described in patients with hodgkin disease who have undergone splenectomy for staging purposes. the organisms commonly associated with sepsis in this setting include streptococcus pneumoniae and haemophilus influenzae. polyvalent pneumococcal vaccine (merck) has recently been licensed and has been suggested for use in patients with hodgkin disease who are at risk for postsplenectomy sepsis. we administered 14-valent pneumococcal vaccine to 24 patients with hod ... | 1979 | 40635 |
| pathogenic species of the genus haemophilus and streptococcus pneumoniae produce immunoglobulin a1 protease. | thirty-seven strains of the genus haemophilus and five strains of streptococcus pneumoniae were examined for their ability to produce extracellular enzyme that cleaves immunoglobulin molecules. all strains of h. influenzae, h. aegyptius, and s. pneumoniae elaborated enzyme that selectively cleaved human immunoglobulin a1 (iga1) myeloma proteins but was inactive against a variety of other proteins including human iga2, igg, and igm, porcine and bovine secretory iga, human and bovine serum albumin ... | 1979 | 40878 |
| bacterial adherence to pharyngeal cells in smokers, nonsmokers, and chronic bronchitics. | selective adherence to host mucosal surfaces is probably a requirement for colonization and infection by bacteria. since pharyngeal colonization may be an important determinant in the pathogenesis of pneumonia, we studied the adherence of 10 different bacteria to pharyngeal cells obtained from nonsmokers, smokers, and chronic bronchitics. various patterns of adherence among the different groups of subjects were found. young healthy smokers had increased adherence of streptococcus pneumoniae type ... | 1979 | 40879 |
| immunoglobulin a1 protease production by haemophilus influenzae and streptococcus pneumoniae. | bacterial strains of haemophilus species and streptococcus pneumoniae were examined for synthesis of the enzyme immunoglobulin a1 (iga1) protease. of 36 h. influenzae strains examined, 35 produced iga1 protease; strains included all six capsular types, unencapsulated variants of types b and d, and untypable h. influenzae. eight haemophilus strains (non-h. influenzae) were studied, and two produced iga1 protease. all 10 strains of s. pneumoniae produced iga1 protease; these strains included 9 dif ... | 1979 | 40880 |
| [a bacteriological investigation of acute purulent otitis media (author's transl)]. | 1979 | 41035 | |
| [range and possibilities of treatment of chronic bronchitis and its complications]. | 1979 | 41227 | |
| [culture and morphological characteristics of haemophilus influenzae and pneumococcus in bronchial infection]. | in the cultures obtained by inoculating sputum samples faken from patients with bronchial infection into solid agar medium prepared on hottinger's hydrolysate with fresh rabbit blood added haemophilus influenzae produced colonies varying in their from (dome-shaped, conical, trapeziform), as well as in the morphology of the organisms. pneumococci produced mainly flat colonies surrounded by the zone of alpha hemolysis. along-side with isolated h. influenzae and pneumococcal colonies, symbiotic col ... | 1979 | 41387 |
| [bacterial coincidence in the infected middle ear and nasopharynx (author's transl)]. | 1979 | 41890 | |
| [action of aortic cathepsin d on serum low-density lipoproteins]. | action of aortic cathepsin d on low density lipoproteins /ldl/ from human serum was studied by means of analytical ultracentrifugation. cathepsin d intensively hydrolysed ldl, leading to decrease in the sedimentation coefficients of the product formed. the product of degradation of ldl possessing a sedimentation coefficient of 4.5 s /in 0,04 m kbr; 0,042 m nacl, 2 mm edta, 6 mm tris, ph 7.3 /contained apparently the minimal amount of proteins, which could still maintain the stability of partiall ... | 1979 | 42218 |
| should we plan a general childhood vaccination against bacterial meningitis? | an estimation of the benefits of vaccination against bacterial meningitis are based on the age-specific incidence of meningitis caused by the different groups of meningococci, by haemophilus influenzae and by pneumococci, and the known efficacy of the present polysaccharide vaccines against these agents. since the incidence of bacterial meningitis is more than ten times higher below the age of five years that at a later age, vaccination at 1 1/2 years of age could prevent a large fraction of all ... | 1979 | 42596 |
| an evaluation of 12 methods for the demonstration of penicillinase. | twelve methods for the demonstration of bacterial penicillinase production by strains of haemophilus influenzae and staphylococcus aureus are compared, and their suitability for routine clinical laboratory use is evaluated. the acidometric agar plate method is recommended. | 1979 | 42650 |
| [the bacteriological diagnosis of pneumonia by transtracheal puncture. value in medical intensive care (author's transl)]. | seventy five patients referred with a diagnosis of pneumonia underwent transtracheal puncture. in 76% of cases this examination led to discovery of an organism in infected patients. in 50% of cases, the bacteriological diagnosis was sufficiently accurately oriented by direct examination to permit rapid and effective treatment. there was virtually perfect agreement with the results of blood cultures when the latter were positive. the organisms most often responsible were gram positive and above a ... | 1979 | 42881 |
| opsonic activity of normal human cerebrospinal fluid for selected bacterial species. | the opsonic activity of normal human cerebrospinal fluid (csf) has not been well defined. in this study, the opsonic activity of normal csf for laboratory and blood culture isolates of staphylococcus aureus, streptococcus pneumoniae, escherichia coli, hemophilus influenzae type b, and neisseria meningitidis was measured by a quantitative assay employing radiolabeled bacteria and polymorphonuclear leukocytes. all isolates of s. aureus, except the wood 46 strain, were opsonized in undiluted csf (> ... | 1979 | 43289 |
| comparative immunogenicity of group 6 pneumococcal type 6a(6) and type 6b(26) capsular polysaccharides. | the comparative immunogenicity of the two cross-reacting group 6 pneumococcal capsular polysaccharides, type 6a(6) and type 6b(26), was studied with hyperimmune rabbit typing antisera and with sera from adult volunteers injected with polyvalent pneumococcal vaccines containing either 50 mug of type 6a (u.s. designation, type 6) or 50 mug each of type 6a and type 6b (u.s. designation, type 26) polysaccharides. both group 6 polysaccharides were linear copolymers composed of 1 mol each of d-galacto ... | 1979 | 43290 |
| quantitative sputum gram stains in chronic bronchial disease. | 1979 | 43418 | |
| [bacteria isolated from cerebrospinal fluid specimens in gothenburg during a 5-year period]. | 1979 | 43439 | |
| unsuspected bacteremia in young children: a common and important problem. | 1979 | 43959 | |
| serotypes of streptococcus pneumoniae causing disease. | serotypes of streptococcus pneumoniae from 525 infected children were examined over a four-year period. type distribution was similar among 84 cases of bacteremia and 30 cases of meningitis, with types 6, 14, and 18 accounting for half of the illnesses. in contrast, half of 396 episodes of otitis media were caused by three other types, 19, 23, and 3. four of eight fatalities were due to type 6. carrier strains isolated from children had a distribution of types similar to that of the otitis media ... | 1979 | 44310 |
| [epidemiologic features of pneumococcal meningitis in africa. clinical and serotypical aspects (author's transl)]. | pneumococcal meningitis, because of their frequency and their severity, are regarded as an important problem of public health in africa. in a great number of african countries, particularly equatorial and central africa, the pneumococcus is the first agent of bacterial meningitis. the annual prevalence is estimated as about 14/100 000 persons. the case fatality rate (on 1 600 cases) is 49,5% ; the annual mortality reaches about 7/100 000 (28 000 annual deaths in africa). the babies and the old p ... | 1979 | 44737 |
| comparative study of erythromycin, amoxicillin and ampicillin antimicrobial activity against human respiratory tract pathogens. | an in vitro test system was used to compare the antimicrobial activity of erythromycin, amoxicillin and ampicillin against respiratory tract pathogens isolated from man. the minimum inhibitory concentrations (mics) of fresh clinical isolates of streptoccus pyogenes, streptocuccus pneumoniae, staphylococcus aureus and haemophilus influenzae to the macrolide and penicillins ranged between 0.01 and 0.9 microgram/ml. the microbes were exposed to each antibiotic for approximately 3 h at 1x,2x and 5x ... | 1979 | 44765 |
| [animal experiments with combined local immunization against an influenza virus disease (author's transl)]. | 1979 | 44774 | |
| evaluation of cefaclor and amoxycillin in the treatment of acute otitis media. | twenty-eight patients with acute otitis media were treated in a random double blind manner with either amoxycillin or cefaclor. the predominant organisms isolated were h. influenzae and s. pneumoniae. all patients responded satisfactorily except one, treated with cefaclor, whose compliance with the regimen was very doubtful. one instance of mild elevation of sgot and one case of mild erythematous rash occurred in each treatment group. in this limited study, cefaclor appeared comparable to amoxyc ... | 1979 | 44907 |
| treatment of acute bacterial bronchitis and pneumonia with cefaclor. | sixty patients with pneumonia and/or bronchitis were treated with cefaclor, a new orally administered cephalosporin. of those 60, 27 adults were treated with 500 mg every 8 hours, 26 adults with 250 mg every 6 hours, and 7 children with 50 mg/kg/day. in the adults, pneumonia was caused most frequently by streptococcus pneumoniae and haemophilus influenzae. the 7 children had pneumococcal pneumonia. all but 2 adults, both elderly patients with chronic obstructive pulmonary disease, were successfu ... | 1979 | 44908 |
| comparative in vitro microbiological activity and stability of cefaclor. | the in vitro activity of cefaclor was compared with that of cephalexin and cephradine. this new antibiotic was the most active of the oral agents against haemophilus influenzae (especially non-beta-lactamase producing strains). it was also significantly more active against n. gonorrhoeae and the enterobacteriaceae. the instability in agar raises some issues that need further study. | 1979 | 44910 |
| [in vitro activity of cefaclor (author's transl)]. | a comparative study was conducted on the in vitro activity of cefaclor and other oral cephalosporins against a large number of freshly isolated clinical strains of gram-negative and gram-positive bacteria. the activity of cefaclor against gram-positive pathogens is very similar to that of cephalexin. the action of cefaclor against streptococcus pneumoniae is superior. cefaclor is the most active antibiotic against strains of haemophilus influenzae, and is also more active than cephalexin and cep ... | 1979 | 45087 |
| emergence of antibiotic resistance in hospitals, 1935-1975. | a limited review of the changes in susceptibility of common bacterial pathogens to available antibacterial agents is presented. significant developments in recent years include the following: (1) the emergence of streptococcus pneumoniae with decreased resistance to penicillin and of some strains resistant to several antibiotics; (2) a decline in prevalence of multi-drug-resistant staphylococcus aureus after 1960 following their increasing prevalence in the preceding years (these changes were me ... | 1979 | 45521 |
| thermal denaturation of dna in situ as studied by acridine orange staining and automated cytofluorometry. | 1975 | 46199 | |
| editorial: antimicrobial treatment of chronic bronchitis. | 1975 | 46968 | |
| letter: chloramphenicol resistance in haemophilus species. | 1975 | 47130 | |
| ampicillin-resistant haemophilus influenzae type b possessing a tem-type beta-lactamase but little permeability barrier to ampicillin. | ampicillin-resistant haemophilus influenzae type b have been reported only during the past year. five clinical isolates from the u.s. and germany all had the tem-type beta-lactamase which is known to be transferred widely among other gram-negative bacilli. unlike those bacilli, however, the h. influenzae cell had very little barrier to entry of penicillins. this greater permeability of the h. influenzae cell to penicillins appeared to reduce the protective effect of its beta-lactamase, in that a ... | 1975 | 47483 |
| letter: pathogenesis of myelopathy in cervical spondylosis. | 2001 | 48156 | |
| induction of serum haemophilus influenzae type b capsular antibodies in adult volunteers fed cross-reacting escherichia coli 075:k100:h5. | serum haemophilus influenzae type b (hitb) anticapsular antibodies were induced in adult volunteers by feeding of either of two strains of a cross-reacting escherichia coli 075:k100:h5. in all the fed volunteers colonization for a finite period lasting up to eight weeks occurred, without adventitious reactions. nine of 14 normal volunteers and one of two volunteers previously immunized with the type 6 h.influenzae polysaccharide responded with a greater than twofold increase in serum type 6h. in ... | 1975 | 48191 |
| release of histamine from rat mast cells by the complement peptides c3a and c5a. | suspensions of rat mast cells were used to study the histamine-releasing actions of anaphylatoxins c3a and c5a in vitro. the peptides, derived from human or porcine complement proteins c3 and c5, were less potent than 48/80 but more potent than bradykinin in stimulating release of histamine from mast cells. the pattern of release resembled that of the anaphylactic release action, e.g. release was limited to less than 30 per cent of the cell histamine, the reaction was calcium-dependent and was p ... | 1975 | 48505 |
| [determination of proteolytic activity of human stomach and duodenum in situ]. | 1975 | 48576 | |
| [method for determination of the bleomycin inactivating enzyme acitivity in tissues]. | an enzyme that inactivates bleomycin (blm) can be extracted from tissue. the activity of this enzyme varies markedly in different tissues. in the present paper, a method is described by which the activity of the blm-inactivating enzyme in different organs and tissues of mice can be determined. the highest activity is found in liver; lower enzyme concentrations occur in the testis, spleen, lung and brain. in skin this enzyme is almost completely missing. | 1992 | 49137 |
| letter: ampicillin-resistant haemophilus influenzae in otitis media. | 1975 | 49485 | |
| editorial: prevention of haemophilus influenzae meningitis. | 1975 | 49657 | |
| immunological study of anthranilate synthetase. | an immunological study of anthranilate synthetase (asase) has been initiated using quantitative precipitation, enzyme neutralization, and immunodiffusion methods. cross-reactivity of anthranilate synthetase-anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferase (asase-prtase) from escherichia coli, klebsiella aerogenes, and salmonella typhimurium and asase from serratia marcescens and pseudomonas putida was detected with antibodies to ?e. coli trypsin-treated asase. cross-reactivit ... | 1975 | 50316 |
| haemophilus influenzae type b resistant to tetracycline isolated from children with meningitis. | during a three-year-period, 1971-73 inclusive, haemophili isolated from 96 children with severe infections, of whom 73 had meningitis and 19 acute epiglottitis, were serotyped and tested for sensitivity to antibacterial drugs. all strains were identified as haemophilus influezae type b, and were sensitive to ampicillin, chloramphenicol, and trimethoprim. however, 3 isolates--from a boy aged 11 months and a girl aged 1 year with meningitis, and a girl aged 2 years with epiglottitis--were highly r ... | 1975 | 53373 |
| changing patterns of bacterial resistance in relation to prophylactic use of cephaloridine and therapeutic use of ampicillin. | antibiotic sensitivities of 15302 organisms of common pathogenic species isolated in one hospital pathology department in 1971 and 1974 have been studied. resistance to cephaloridine did not change materially. the proportion of strains resistant to ampicillin did, however, increase, and this is attributed to the widespread therapeutic use of the antibiotic. cephaloridine, on the other hand, was largely used in the hospital as a single-dose, intra-incisional prophylactic against surgical wound se ... | 1975 | 53736 |
| cell-mediated immune response in mice treated with steroidal contraceptives. | the splenomegaly assay (simonsen, 1962) was standardized using different strains of rats and mice. male wistar rat (donor)-female swiss mouse (host) was found to be the suitable combination that could be employed in subsequent experiments to study the potential of contraceptive steroids to alter cmir. the index of splenomegaly appeared to increase in case of mice treated with combination oral contraceptives (ovulen, ovral or enovid). the differences observed, however, neared significance only in ... | 1975 | 55327 |
| evidence for more than one ia antigenic specificity on molecules determined by the i-a subregion of the mouse major histocompatibility complex. | ia antigenic specificities determined by the i-a subregion of the mouse major histocompatibility complex have been examined in strain b10.d2 (h-2d), c57bl/10 (h-2b), and in a (c57bl/6xdba/2) hybrid (bdf1; h-2b/d). detergent solubilized, 3h-leucine-labeled antigen preparations were mixed with appropriate alloantisera and precipitation was induced either by addition of goat anti-mouse gamma-globulin or by addition of protein a-bearing staphylococci. sequential precipitation analysis showed that in ... | 1976 | 55444 |
| retention and redistribution of proteins in mammalian nerve fibres by axoplasmic transport. | fast axoplasmic transport is characterized by a crest of labelled activity moving down nerve fibres after injection of the l7 dorsal root ganglion with the amino acid precursor (3h) leucine, the crest followed by a plateau which represents in part a later egress of labelled components from compartments in the cell bodies and in part materials left behind the advancing crest. 2. after making ligations just below the ganglia at different times after injection of the precursor, a small downward slo ... | 1975 | 55480 |