Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| a newly recognized fastidious gram-negative pathogen as a cause of fever and bacteremia. | we identified a motile, curved, gram-negative bacillus as the cause of persistent fever and bacteremia in two patients with symptomatic human immunodeficiency virus infection. the same organism was subsequently recovered from a bone marrow-transplant recipient with septicemia and from two immunocompetent persons with week-long febrile illnesses. all the patients recovered after antimicrobial therapy. | 1990 | 2233947 |
| pleuropulmonary tularemia: successful treatment with erythromycin. | a 64-year-old man had community-acquired pneumonia that was retrospectively diagnosed as pleuropulmonary tularemia. he was successfully treated with erythromycin. we review the case and briefly discuss the literature on this point. | 1990 | 2237578 |
| [the meadow-field type of tularemia foci in eastern siberia]. | the article characterizes a meadow-type focus tularemia, discovered in zalarinski'i district of irkutsk province in 1988. this focus and another similar focus discovered in 1985 at the krasnoyarsk territory belong to the meadow type, which makes it possible to regard their presence in eastern siberia as an established fact. the main reservoirs and sources of infection in these foci are two species of voles (microtus gregalis and m. subarvalis). | 1990 | 2239002 |
| [natural penicillin resistance of francisella tularensis]. | altered viable forms of f. tularensis with spheroplast specific damages of the surface structures were isolated after the culture exposure to lithium chloride (0.5 and 1%). study of natural penicillin resistance in the spheroplasts and bacterial forms of f. tularensis revealed their difference: the spheroplasts of the strains tested had a lower resistance to beta-lactam antibiotics than the bacterial forms while the activity of spheroplast beta-lactamase did not differ from that of the enzyme of ... | 1990 | 2264748 |
| [comparative study of the effectiveness of amikacin and streptomycin in experimental tularemia]. | in vitro study on antibacterial activity of amikacin in comparison to that of streptomycin revealed a high sensitivity of tularemia microbes of three geographical races to it. amikacin showed a high therapeutic activity in treatment of albino mice infected with tularemia. the prospects of amikacin use in prophylaxis and treatment of tularemia are defined by its antibiotic activity against streptomycin-resistant forms of the tularemia causative agent. | 1990 | 2264751 |
| an unlucky rabbit's foot? | 1990 | 2314975 | |
| a case of tularemia meningitis in sweden. | tularemia meningitis occurred in a previously healthy 64-year-old man from northern sweden. the patient was immunocompetent and recovered without sequelae. the bacterial isolate conformed by most criteria with the euro-asian biovar francisella tularensis var. palaearctica. tularemia meningitis may mimic meningitis caused by mycobacterium tuberculosis. | 1990 | 2320968 |
| lawnmower tularemia. | 1990 | 2336320 | |
| acute bacterial meningitis caused by francisella tularensis. | 1990 | 2336321 | |
| serological prevalence of tularemia in cottontail rabbits of southern illinois. | sera of cottontail rabbits (sylvilagus floridanus) collected in southern illinois in 1983 and 1984 were screened for the presence of antibodies against francisella tularensis by rapid slide agglutination and enzyme linked immunosorbent assay techniques; 6% of 118 and 16% of 119 samples were positive by these methods, respectively. rabbits gained, lost and maintained titers over at least an 8 mo period. francisella tularensis tularensis was isolated from one serologically negative, clinically hea ... | 1990 | 2338733 |
| [infestation of ticks with borrelia burgdorferi and francisella tularensis in slovakia]. | examination of ticks for the presence of f. tularensis resulted in the isolation of 29 strains, predominantly from the species d. reticulatus (19x), further from i. ricinus (8x) and from h. concinna (2x). the results confirmed the activity of the known endemic focus in the area of podunajské biskupice and revealed three new foci in the localities smolenice (district of trnava), olichov (district of nitra), and plást'ovce (district of levice). in the focus of podunajské biskupice the mean infesta ... | 1990 | 2376012 |
| [the dynamics of antibody formation to a vaccinal strain of francisella tularensis in different immunization regimens]. | the use of different schemes of albino mice immunization either by living or by killed preparations of the vaccine strain of francisella tularensis when obtaining monoclonal antibodies to the tularemia microbe made it possible to reveal definite regularities in the dynamics of antibody formation. the highest titres of antibodies in sera of animals-donors of splenocytes were obtained during the daily (for 3 days) intraperitoneal immunization of mice with living vaccine or with its thrice administ ... | 1990 | 2377086 |
| massive adenopathy in oropharyngeal tularemia; c.t. demonstration. | the ct appearance of oropharyngeal tularemia in a 3 1/2 year-old boy is described. tularemia should be considered in the differential diagnosis of massive adenotonsillar enlargement and extensive necrotic cervical adenopathy. | 1990 | 2392370 |
| antigen-induced monocyte procoagulant activity. requirement for antigen presentation and histocompatibility leukocyte antigen-dr molecules. | the present study explores the interactions between lymphocytes and monocytes that are required for expression of procoagulant activity (pca) by monocytes in response to purified protein derivative of the tubercle bacillus (ppd) or tularemia antigen. the pca response was antigen specific: peripheral blood mononuclear cells (pbm) from donors sensitive to ppd or tularemia showed an increase in pca only in response to the sensitizing antigen. the pca was tissue factorlike in that factors vii and x ... | 1985 | 2413076 |
| cat scratch disease. identification of bacteria in seven cases of lymphadenitis. | a retrospective study of lymph node biopsy specimens from nine patients with the clinical findings and histologic features of cat scratch disease was undertaken to determine whether the recent report by wear et al. that pleomorphic bacteria are present in the lymph nodes of cat scratch disease could be confirmed. in seven of our nine cases, pleomorphic bacteria were demonstrated with the warthin-starry (ws) silver stain. these were gram-negative with the brown-hopps tissue gram stain and were al ... | 1986 | 2422962 |
| [taxonomy and systematics of pathogenic microorganisms]. | the modern state of the problem of the systematics of microorganisms is analyzed and the data on the taxonomy of bacteria belonging to the family enterobacteriaceae are presented. the importance of studies on the taxonomy of microorganisms is emphasized. these studies play a vital role in the development of diagnostic preparations and techniques for the identification of infective agents, as well as in the realization of epidemiological surveillance. much attention is given to the works of sovie ... | 1986 | 2432744 |
| [use of the elisa immunoenzyme method for the detection of the causative agent of tularemia]. | the conditions of the enzyme-linked immunosorbent assay (elisa) for the detection of francisella tularensis were worked out. in the study of 27 strains differing in their biological characteristics, the sensitivity of the assay was determined, varying within the range of 1 x 10(4)--5 x 10(4) million cells/ml and exceeding the sensitivity of the currently used methods for the immunodiagnosis of tularemia by 1-2 orders. elisa also proved to be a highly effective technique for the detection of the ... | 1988 | 2452535 |
| [a coagglutination reagent for identifying the causative agent of tularemia]. | 1988 | 2462096 | |
| francisella tularensis-specific t-cell clones are human leukocyte antigen class ii restricted, secrete interleukin-2 and gamma interferon, and induce immunoglobulin production. | t-cell clones (tlc) were established from a francisella tularensis-vaccinated subject in order to study the cells responsive for cell-mediated immunity against f. tularensis. all the clones were human leukocyte antigen (hla) class ii restricted to one of the hla-dr specificities of the original donor. the tlc cells were cd4+ and produced interleukin-2 and gamma interferon after stimulation with specific antigen. seven of the eight clones tested assisted in the production of immunoglobulin g (igg ... | 1989 | 2474506 |
| molecular cloning and expression of a t-cell stimulating membrane protein of francisella tularensis. | the isolation and expression in escherichia coli of a gene encoding a t-cell stimulating 17 kilodalton (kda) membrane protein of francisella tularensis is described. a genomic library of dna from the live vaccine strain lvs of f. tularensis was constructed in the e. coli expression vector phage lambda gt11. the library was probed with antibodies directed against the 17 kda protein. one recombinant phage was isolated, containing a 2.8 kilobase (kb) dna insert. the insert was cleaved and a resulti ... | 1989 | 2475738 |
| production of murine monoclonal antibodies against francisella tularensis antigens and characterization of antibody-reactive epitopes. | eight monoclonal antibodies were produced by immunizing mice with a high molecular-weight antigen from francisella tularensis. the antigen consists of carbohydrates and proteins and was found to contain several different epitopes. by treating the antigen with periodate or proteinase k, it was found that the majority of antibody-reactive epitopes was mainly dependent on the carbohydrate part of the antigen. on intact f. tularensis bacteria the epitopes seem to be exposed at the bacterial surface. ... | 1989 | 2478486 |
| protein heterogeneity of francisella tularensis: detection of proteins with antigenic determinants. | the autolyzates of three different strains of francisella tularensis 15l, 130 and schu were tested for their immunogenic potential and protein heterogeneity. the autolyzates induce the production of specific antibodies, the delayed type of hypersensitivity, and some degree of protection against european virulent strain 130. this material (as antigen) was especially suitable for elisa. when the autolyzates were subjected to sds gradient page, a variety of polypeptides were distinguished. the comp ... | 1989 | 2481633 |
| [old and new pathologies proposed by epidemiology]. | the results of a study made in the areas of central italy on a random community on the significant presence of cases with seroantibodies against campylobacter, yersinia, legionella pneumophila, francisella tularensis and rotavirus confirm the hypothesis on the presence in the territory of microorganisms responsible. these positivities in man are not only single but also contemporaneous for at least two microorganisms. hence the hypothesis of the presence in the environment (animals, soil, surfac ... | 1989 | 2490401 |
| isolation of francisella tularensis biovar palaearctica from human blood. | francisella tularensis septicemia has previously been reported in the usa, where francisella tularensis biovar tularensis (type a) occurs endemically. the present report describes two cases of septicemia caused by the euro-asian francisella tularensis biovar palaearctica (type b). the patients lived in an endemic region of sweden and presented with high fever and pneumonia. both patients recovered. the ability of francisella tularensis biovar palaearctica to cause bacteremia has consequences for ... | 1989 | 2498098 |
| [the action of tularemia vaccine on dmba-induced tumors in rats]. | 1989 | 2499117 | |
| the requirement for gamma interferon in resistance of mice to experimental tularemia. | the role of gamma interferon (ifn-gamma) in the host response to experimental tularemia was evaluated in a murine model. c57bl/6 strain mice were given a series of daily intravenous injections of 10(6) units (u) recombinant murine ifn-gamma prior to infection with francisella tularensis lvs. three days later, the number of bacteria in the tissues of ifn-gamma-treated mice was found to be less than that in control mice by a factor of 10-20. the effect of ifn-gamma on anti-tularemic resistance was ... | 1989 | 2516219 |
| comparative studies on susceptibility of the mouse (mus musculus) and the vole (microtus arvalis) to listeria monocytogenes and erysipelothrix rhusiopathiae. | the susceptibility of mice and voles to intraperitoneal and subcutan injection of virulent strains has been tested comparatively on 261 mice and 120 voles. using various germ-doses, 50 per cent lethality has been established. listeria monocytogenes serovar 1/2a killed mice in doses of 120,000 and 1.5 x 10(6) germs when injected intraperitoneally and subcutaneously and voles in doses of 1800 and 12,000 germs, respectively. thus voles proved 100 to 120 times more susceptible than mice. erysipeloth ... | 1989 | 2517160 |
| [outer membranes of francisella tularensis and their protein composition]. | four strains of the species francisella tularensis were used in the present work: a live vaccine strain 15/10 and three virulent strains (503, schu, 543) from three different subspecies. the bacterial membranes were prepared by the 0.5% n-laurylsarcosinate (sarcosyl) treatment. these membranes were identified as the outer membranes by morphological, immunological and biochemical analyses. the outer membrane proteins contained up to 30-35 polypeptides with three dominant fractions having the 63, ... | 1989 | 2517513 |
| infection caused by francisella philomiragia (formerly yersinia philomiragia). a newly recognized human pathogen. | we evaluated the clinical characteristics of patients with francisella philomiragia (formerly yersinia philomiragia) isolated from normally sterile sites. isolates from 14 patients were received by the centers for disease control between 1975 and 1987: 9 were from blood; 2 from lung biopsies; and 1 each from pleural, peritoneal, and cerebrospinal fluid. underlying problems included chronic granulomatous disease in 5 patients, near-drowning in 5, and a myeloproliferative disease in 2. all 13 pati ... | 1989 | 2541646 |
| monoclonal antibodies reacting specifically with francisella sp. | twenty two hybridoma strains producing monoclonal antibodies against francisella tularensis atcc 6223, var. tularensis, were characterized. in an enzyme-linked-immunosorbent-assay (elisa) using formaldehyde fixed bacteria as antigens, neither cross-reactions with six different brucella spp., with yersinia enterocolitica 0:9 nor with two biotypes of yersinia pseudotuberculosis could be detected. the antibodies gave comparable titres with the three strains of f.tularensis tested. elisa binding stu ... | 1989 | 2596200 |
| ulceroglandular tularemia: a typical case of relapse. | tularemia is an infectious disease that continues to occur sporadically and in epidemics in the united states. it is characterized as an acute febrile illness with constitutional symptoms associated with skin, glandular, respiratory, or gastrointestinal involvement. tularemia usually can be treated effectively with streptomycin. relapse most often occurs when patients are treated with bacteriostatic agents such as chloramphenicol or tetracycline. we present a case of ulceroglandular tularemia di ... | 1989 | 2606733 |
| [sensitivity spectrum of francisella tularensis to antibiotics and synthetic antibacterial drugs]. | sensitivity of 6 f. tularensis strains to 57 antibiotics and synthetic antibacterial drugs was studied. it was shown that the strains were highly sensitive to aminoglycosides, tetracyclines, anzamycins, quinolones, chloramphenicol, nitrofurantoin, nitroxoline, novobiocin and fusidin and resistant to penicillins, cephalosporins, polypeptides, vancomycin and sulfanylamides. the interrace differences in f. tularensis could be detected only by sensitivity to erythromycin, oleandomycin and spiramycin ... | 1989 | 2610533 |
| membrane proteins of francisella tularensis lvs differ in ability to induce proliferation of lymphocytes from tularemia-vaccinated individuals. | t lymphocyte-mediated immunity is important for resistance to francisella tularensis. to characterize the specificity of this immunity, we used membrane proteins and two lipopolysaccharide (lps) preparations. both membrane proteins were heat-modifiable, as indicated by their migration in sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page). one had an apparent molecular mass (mm) of 120 kilodaltons (kda) when solubilized in the sds buffer at room temperature, but 17 kda after he ... | 1989 | 2622330 |
| [the cytogenetic action of x-ray irradiation on the myelokaryocytes of rats immunized with a tularemia vaccine]. | immunization with tularemic live dry vaccine administered singularly to wistar rats skin has been studied for its effect on mutagenicity induced after whole-body x irradiation. the analysis has shown that cytogenetic disturbance induced after x irradiation with doses of 0.5 gy and 1.0 gy in immunized animals significantly decreases as compared to nonimmunized animals. | 1989 | 2623763 |
| growth and survival of four strains of francisella tularensis in a rich medium preconditioned with acanthamoeba palestinensis. | the hypothesis of positive interactions between francisella tularensis lvs (live vaccine strain) and acanthamoeba palestinensis was tested. pregrowth of the amoebae, in a rich (autoclaved and filtered) medium, from which they were subsequently removed by filtration, conditioned the medium so that growth of the live vaccine strain of f. tularensis occurred and the growth rate of one other strain was increased. | 1989 | 2630032 |
| [various mechanisms of formation of chronic tularemia in highly-sensitive animal species (microtus rossiae-meridionalis)]. | experiments on voles belonging to the tularemia-sensitive species microtus rossiae-meridionalis, infected with francisella tularensis highly virulent strain 503, have been carried out with the aim of studying the pathogenesis of chronic tularemia. the experiments have been made with the use of live and killed microbial cells. the significance of the multiple oral administration of killed bacteria to voles for the development of the atypical form of infection has been shown. the possibility of th ... | 1989 | 2660474 |
| [detection of tularemia pathogens in patients with the use of an immunofluorescence reaction]. | for the first time three cases of the detection of francisella tularensis, made by means of the direct immunofluorescence test in the fluid obtained from punctured buboes or in purulent matter taken from patients with the ulcerous bubonic form of tularemia, are presented. the simplicity of the test and its capacity of yielding rapid results make it possible to recommend this test, together with other diagnostic methods, for the clinical diagnosis of tularemia. | 1989 | 2660477 |
| nature of protective immunity to francisella tularensis. | tularemia is caused by the facultative intracellular bacterium francisella tularensis. attenuated live vaccines, such as f. tularensis lvs (live vaccine strain), afford good--although not complete--protection; how to judge the degree of this protection has long been a problem. both natural infection and vaccination result in immunospecific and long-lasting humoral and cell-mediated immunity. the latter is the crucial protective mechanism, whereas the humoral response protects only against strain ... | 1989 | 2665002 |
| francisella philomiragia comb. nov. (formerly yersinia philomiragia) and francisella tularensis biogroup novicida (formerly francisella novicida) associated with human disease. | over a 12-year period, 16 human strains of a gram-negative, catalase-positive, halophilic, aerobic, nonmotile, small coccoid bacterium were received for identification. on the bases of biochemical characteristics and cellular fatty acid profiles, 14 of these strains were similar to the "philomiragia" bacterium (yersinia philomiragia, species incertae sedis). additional characteristics were growth on thayer-martin agar but no growth or sparse, delayed growth on macconkey agar; oxidase positive; a ... | 1989 | 2671019 |
| [delayed type hypersensitivity reaction in the pathogenesis and formation of immunity in tularemia infections in mice]. | as a result of our studies, strain differences in the sensitivity of cba and balb/c mice to partially attenuated francisella tularensis strain have been revealed. relationship between the increased migration of lymphocytes to the liver and lymphoid organs and the intensive development of cell-mediated immunity reactions has been shown. an important role of local reactions (the skin at the site of the inoculation of f. tularessis + a regional lymph node) in the development of the pathological pro ... | 1989 | 2728707 |
| guillain-barré syndrome and tularemia pleuritis with high adenosine deaminase activity in pleural fluid. | a 56-year-old man suffered from prolonged fever, sore throat and cough, followed by pleural effusion and reversible progressive ascending muscle weakness. the condition fulfilled the diagnostic criteria of guillain-barré syndrome. tuberculosis was initially suspected because of lymphocyte predominance and high adenosine deaminase activity in the pleural fluid. later, an agglutination titer of 10,240 to francisella tularensis antigen was found and an infected hare exposure could be identified. th ... | 1989 | 2737756 |
| competitive enzyme immunoassay for antibodies to a 43,000-molecular-weight francisella tularensis outer membrane protein for the diagnosis of tularemia. | antibodies against a 43,000-molecular-weight francisella tularensis outer membrane (om) protein (43k protein) were measured in paired serum specimens from 23 patients with tularemia and matched against antibodies in sera from 25 patients with nontularemic infectious diseases and from 25 blood donors. antibodies were measured by a competition enzyme-linked immunosorbent assay which tested the ability of human serum to compete with rabbit anti-43k protein antibodies for its binding to the f. tular ... | 1989 | 2745701 |
| [decrease in the cytogenetic effect of adriblastin and pharmorubicin with the experimental use of tularemia vaccine]. | immunization of wistar rats with tularemic vaccine has been studied for its influence on the cytogenetic effect of adryblastine and pharmorubicyn. it is shown that the number of aberrant metaphases considerably decreases in the myelocaryocytes of vaccinated rats. antimutagenic effect is induced by the influence of tularemic vaccine on the metabolic activation processes of antibiotics and, possibly, by an increase of the activity of antioxidative enzymes in the rat organism. | 1989 | 2815329 |
| serological survey for selected diseases in the endangered san joaquin kit fox (vulpes macrotis mutica). | blood from endangered san joaquin kit foxes (vulpes macrotis mutica) inhabiting the elk hills naval petroleum reserve, kern county, and the elkhorn plain, san luis obispo county, california, was collected in 1981, 1982 and 1984 and sera were tested for antibodies against 10 selected pathogens. proportions of kit fox sera containing antibodies against pathogens were: canine parvovirus, 100% in 1981-1982 and 67% in 1984; infectious canine hepatitis virus, 6% in 1981-1982 and 21% in 1984; canine di ... | 1988 | 2836636 |
| infections with francisella tularensis biovar palaearctica in hares (lepus timidus, lepus europaeus) from sweden. | the occurrence of tularemia was studied in 1,500 hares submitted to the national veterinary institute, uppsala, sweden for postmortem examination during 1973 through 1985. a total of 109 tularemia cases was recorded based on the fluorescent antibody (fa) test for francisella tularensis and on the gross and microscopic pathology. tularemia was diagnosed only in the varying hare (lepus timidus) and not in the european brown hare (lepus europaeus). the geographical distribution of the 109 cases ind ... | 1988 | 2900904 |
| italian epidemic of waterborne tularaemia. | 1988 | 2904549 | |
| [the effect of tularemia vaccine on the radioresistance of white rats exposed to x-irradiation]. | a single epicutaneous vaccination of wistar rats with tularemic live vaccine 15 days before x-irradiation with doses of 6.0, 8.0 and 2.0 + 6.0 gy was shown to increase their radioresistance. with higher doses (up to 8.0 gy) the effect of the vaccine was less pronounced. | 1989 | 2928478 |
| [delayed hypersensitivity and nonspecific cellular immunity. the conditions determining the maximally expressed immunity activity]. | in vivo experiments on the infection of mice with influenza a virus and francisella tularensis and in vitro experiments on the bactericidal activity of macrophages have demonstrated the conditions leading to the maximally pronounced activation of immunity by means of preparations inducing delayed hypersensitivity (dh). the following conditions have been determined: the presence of pronounced dh previously to the injection of old tuberculin (ot) and staphylococcal phagolysate (sp) used as challen ... | 1986 | 2941945 |
| [isolation of francisella tularensis from ixodes ricinus ticks in the protected environment of palava]. | 1987 | 2958150 | |
| [properties of the plasmid pft15/10-1 isolated from the vaccine strain of francisella tularensis]. | plasmid, designated pft15/10-1, was isolated from francisella tularensis vaccine strain 15/10. the plasmid is presented by the homogeneous 5.02 +/- 0.054 md monomeric circular dna molecules in electron microscopic preparations. plasmid size is 7-7.3 kb as defined by electrophoresis in agarose gel. the restriction analysis has revealed that plasmid pft15/10-1 possesses a single specific cleavage site for restriction endonuclease ecori, two sites for restriction endonucleases bamhi, bgiii, hincii, ... | 1985 | 3025707 |
| serologic survey for selected microbial pathogens of wolves in alaska, 1975-1982. | serum samples were collected from 116 wolves which were captured in southcentral alaska during 1975 through 1982. antibodies to the following infectious disease agents were found: infectious canine hepatitis virus-72 of 87 (81%), canine parvovirus type 2-0 of 55 (0%) through 1979 and 10 of 32 (31%) after 1979, francisella tularensis-16 of 67 (25%), canine distemper virus-10 of 83 (12%), coxiella burnetti-5 of 95 (5%), rabies virus-1 of 88 (1%), brucella spp.-1 of 67 (1%), leptospira interrogans- ... | 1987 | 3029442 |
| interleukin 2 and gamma interferon production, interleukin 2 receptor expression, and dna synthesis induced by tularemia antigen in vitro after natural infection or vaccination. | the t-cell response induced by francisella tularensis antigen in sensitized subjects was characterized in vitro by measuring dna synthesis in whole-blood and mononuclear cell cultures, interleukin 2 (il-2) and gamma interferon (ifn-gamma) production, and il-2 receptor expression. correlations between these variables were estimated. the strengths of the responses were compared in 21 subjects naturally infected 2 years ago, 6 subjects vaccinated 5 to 6 years ago, and 13 control subjects with no hi ... | 1987 | 3110207 |
| [histone-like nature of bacterial allergens used in diagnosing delayed hypersensitivity reaction]. | in this work new data are presented on the comparative quantitative amino acid analysis of allergens, isolated and purified from different bacteria. on the basis of a high content of basic amino acids, such as lysine, arginine and histidine, in mycobacterium, brucella and francisella tularensis allergens, a suggestion is made to classify bacterial allergens with histone-like proteins. | 1988 | 3143203 |
| [rise in the epizootic activity of a natural focus of steppe-type tularemia in stavropol territory and its epidemic consequences]. | one of recurrent autumn and winter rises in the epizootic activity of the steppe-type focus of tularemia in the stavropol territory is described. during the tularemia epizooty of 1981-1982 the population of common voles (microtus arvalis) was very numerous, while the population of house mice (mus musculus) was comparatively scarce. francisella tularensis strains were isolated from different species of rodents (microtus arvalis, mus musculus, apodemus sylvanicus, rattus norvegicus, lepus, etc.), ... | 1985 | 3158139 |
| typhoidal tularemia presenting as enteritis with leukopenia. | 1988 | 3176624 | |
| [information value of the indices of the nonspecific resistance of the body]. | a number of nonspecific resistance characteristics in mice, such as the total number of peritoneal exudate cells, the percentage and absolute number of macrophages, their cytochemical activity in the spontaneous tetrazolium test and cytochemical capacity, have been studied by comparison with the resistance of the animals to tularemia infection induced by francisella tularensis, gaĭskiĭ's vaccinal strain 15. of these characteristics, the cytochemical capacity of peritoneal exudate macrophages, i. ... | 1988 | 3176784 |
| enhancing recovery of francisella tularensis from blood. | francisella tularensis may be isolated with the bactec 460 blood culture system even though bottles may not meet the established criteria for recognizing positive blood cultures. we describe three proven bacteremic cases in which growth indices were not positive, gram stain of broth showed no microorganisms but f. tularensis grew on chocolate agar culture. | 1988 | 3229097 |
| identification of a heat-modifiable protein of francisella tularensis and molecular cloning of the encoding gene. | as an initial step in defining the constituents of the outer surfaces of francisella tularensis, membrane fractions were prepared, and the immunoreactivity of constituents examined by western immunoblotting. one protein, thought to be an outer membrane protein, was found to be heat and beta-mercaptoethanol (2-me)-modifiable and was named fopa. this protein migrates at an apparent molecular weight of 34 kilodaltons (kda) when cell extracts are solubilized below 80 degrees c, but migrates as a dou ... | 1988 | 3237052 |
| h-2 restriction in acquired cell-mediated immunity to infection with francisella tularensis lvs. | the h-2 restriction imposed on the t-lymphocyte-macrophage interaction leading to the expression of acquired cellular immunity was evaluated in an experimental model of infection with the live vaccine strain of francisella tularensis. restriction between t cells and macrophages was examined in vitro in cultures containing macrophages from c57bl/10 (b10) mice, t cells from immune b10 h-2 congenic mice, and f. tularensis antigen. the cellular interaction was assayed by the production in the cultur ... | 1988 | 3257461 |
| comparison of serum and lung extracts for surveys of wild animals for antibodies to francisella tularensis biovar palaearctica. | a comparative study of the antibody titer against francisella tularensis biovar palaearctica in serum and lung extract was made using different immunoassays. samples were taken from experimentally-infected goshawks (accipiter gentilis) and european beavers (castor fiber), and in a field survey of wild beavers. good accordance between the antibody titer in serum and in lung extract was found in the experimental studies. however, the antibody titer was generally one- to three-fold lower in lung ex ... | 1988 | 3280838 |
| experimental infection of five species of raptors and of hooded crows with francisella tularensis biovar palaearctica. | sixteen raptors and three hooded crows were infected experimentally with francisella tularensis biovar palaearctica. the birds were infected parenterally or per os. one goshawk, one sparrow hawk and one hooded crow died during the experimental period, and the remaining 16 birds were killed 14-77 days after the first infection. francisella tularensis was not isolated from any bird. antibody levels against f. tularensis measured in nine birds varied from 0 to 1:1,280. in one goshawk with a titer o ... | 1988 | 3280839 |
| [possible atypical course of tularemia (persistence) in the common vole microtus arvalis pall]. | the possibility of the atypical course of tularemia with the prolonged persistence of francisella tularensis in common voles (m. arvalis), the twin species of east european voles (m. rossiaemeridionalis), was studied. experiments were made on 33 animals grown in the laboratory. f. tularensis strain 165 was used. the animals were infected by feeding them according to the previously developed scheme. 7 out of 33 voles showed the atypical course of tularemia: in 3 voles the disease took a prolonged ... | 1987 | 3296576 |
| [choice of the suitability criteria of polystyrene-based solid-phase carriers for performing immunoenzyme analyses]. | the authors discuss a tentative approach to the choice of criteria indicating the optimal suitability of different solid-phase carriers made of polystyrene for use in the enzyme immunoassay (eia), viz. the dependence of specificity, sensitivity, reproducibility and reliability of eia results on the adsorption properties, transparency expressed in percent and transparency variations of the plates under test. the evaluation of the carriers by four parameters is proposed with the use of assay plate ... | 1987 | 3318247 |
| a capsule-deficient mutant of francisella tularensis lvs exhibits enhanced sensitivity to killing by serum but diminished sensitivity to killing by polymorphonuclear leukocytes. | the live vaccine strain (lvs) of francisella tularensis is killed by human polymorphonuclear leukocytes as a result of strictly oxygen-dependent mechanisms (s. löfgren, a. tärnvik, m. thore, and j. carlsson, infect. immun. 43:730-734, 1984). we now report that a capsule-deficient (cap-) mutant of lvs survives in the leukocytes. in contrast to the encapsulated parent strain, the cap- mutant was avirulent in mice and was susceptible to the bactericidal effect of nonimmune human serum. the mutant w ... | 1988 | 3356465 |
| agglutinins and antibodies to francisella tularensis outer membrane antigens in the early diagnosis of disease during an outbreak of tularemia. | tularemia was diagnosed in 57 patients during an outbreak in central norway in 1984 and 1985. clinical categories of the disease showed seasonal variations. a bacterial microagglutination test and an enzyme-linked immunosorbent assay (elisa) with class-specific antibodies against francisella tularensis outer membrane (om) antigens were evaluated for the early diagnosis of tularemia. elisa with immunoglobulin g (igg), iga, or igm antibodies and the microagglutination test differed only marginally ... | 1988 | 3356786 |
| influence of genetic background on host resistance to experimental murine tularemia. | the host response to experimental murine tularemia was examined in different inbred mouse strains. the kinetics of growth of francisella tularensis live vaccine strain (lvs) in the livers and spleens of a and c57bl/6 mice were monitored, and it was observed that mice of the a strain were more susceptible to the proliferation of lvs than were c57bl/6 mice. the difference was most marked 5 days following infection, when the number of bacteria isolated from the spleens of a mice was found to exceed ... | 1988 | 3397185 |
| [a danish case report of tularemia]. | 1987 | 3433508 | |
| [tularemia study in khmel'nitski province]. | the differentiated approach to carrying out the vaccinal prophylaxis of tularemia is necessary in view of the determination of the types of the natural foci of this infection and their epizootic manifestation, as well as taking into account concrete local conditions and social factors. at the same time, the level of zooparasitological investigations must be maintained for the timely determination of the activity and spread of the natural foci of tularemia. | 1987 | 3434047 |
| [the role of serological examination of the excrement of predatory birds for the evaluation of the epizootic situation]. | 1987 | 3445555 | |
| immunospecific t-lymphocyte stimulation by membrane proteins from francisella tularensis. | membranes from a capsule-deficient mutant of the live-vaccine strain of francisella tularensis (f. tularensis lvs) were treated with n-lauroyl sarcosinate (sarkosyl; ciba-geigy corp., summit, n.j.). when the sarkosyl-insoluble fraction was heated in the presence of sodium dodecyl sulfate and mercaptoethanol and subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis, several polypeptides were distinguished. four major polypeptides were eluted from the gel, each of which stimulated ... | 1987 | 3494744 |
| experimental murine tularemia caused by francisella tularensis, live vaccine strain: a model of acquired cellular resistance. | we have established a model of experimentally-induced tularemia in mice, using the live vaccine strain of francisella tularensis. a sublethal, intravenous inoculation of this organism caused in c57bl/6 strain mice an acute infection which lasted approximately 12 days. the clearance of francisella from the bloodstream was shown to be complete by 5.5 hours postinfection. at this time, approximately twice as many bacteria were isolated from the spleen as from the liver. mice which had recovered fro ... | 1987 | 3507552 |
| [polymorphic tularemia]. | 1986 | 3522188 | |
| tularemic hepatitis presenting as obstructive jaundice. | a 56-yr-old man was admitted for evaluation of fever, chills, jaundice, and alcoholic stools. laboratory studies suggested a cholestatic process. ultrasonography, computed tomography, and transhepatic cholangiography failed to reveal any abnormalities. acute infection with francisella tularensis was confirmed serologically, and a liver biopsy revealed cholestatic hepatitis with focal coagulative necrosis. recovery was coincident with antibiotic therapy. | 1986 | 3522344 |
| [transparent nutrient medium for culturing francisella tularensis]. | a transparent nutrient medium t (tularemic) for cultivation of f. tularensis was developed on the basis of heart-brain infusion, yeast extract, bactotryptone, technical casamino acids, bactoagar, salts, l-cysteine and glucose. introduction of an antibiotic (polymyxin b, 100 units/ml) to the medium composition provided selective conditions for growth of f. tularensis. comparative study of the medium growth properties revealed that medium t by this parameter was not inferior to the emel'ianova and ... | 1987 | 3551821 |
| a waterborne tularemia outbreak. | a waterborne tularemia outbreak is described. forty nine cases were identified in sansepolcro, a small medioeval town in the province of arezzo, tuscany, italy. all cases had laterocervical or sub-mandibular adenitis, and occurred within a period of three weeks during march and april 1982. the study showed association between cases and the consumption of water from an unchlorinated water system. francisella tularensis type 1 was isolated from wild hares captured in the area. | 1987 | 3582597 |
| [effect of land reclamation on the transformation of the types of natural tularemia foci]. | land reclamation measures carried out on the territory of a flood-plain-paludal focus of tularemia change the ecological and biocenotic links, which leads to the formation of a meadow-field focus with other-than-before sources and vectors of tularemia infection. | 1987 | 3618024 |
| detection of antigen in urine of a patient with tularemia. | 1987 | 3622500 | |
| [epidemiology and prevention of tularemia]. | 1987 | 3646961 | |
| [from a randomized assay, francisella turned out to be epidemiologically present in the studied areas]. | in the past tularemia has largely affected animals, nowadays' in our country it could become actual one more because of wild animals repopulation actuated in many areas. unlike the other countries, in italy it's not well known if there are any consequences on population. the authors has conducted a research on this subject studying seroimmunologically samples taken randomly in some areas of south-central italy. their results confirm endemism and therefore announce the problem and the consequent ... | 1986 | 3678666 |
| some diagnostic, biologic and morphologic characteristics of francisella tularensis strains isolated from the ticks ixodes ricinus (l.) in the prague agglomeration. | four infectious agents were isolated from the ticks ixodes ricinus (l.) collected in the recreational area and park-forest of prague. on the basis of cultivation, staining, biochemical, serologic properties, pathogenicity for animals and histological tests they were identified as francisella tularensis with the following features: they are short, gram-negative rods of approximate dimensions of 0.3 x 0.8 micron, growing in enriched media after 3-4 day incubation at 37 degrees c. they form small c ... | 1986 | 3699624 |
| francisella tularensis infection in captive, wild caught prairie dogs. | an adult, wild caught prairie dog was found dehydrated and ataxic, with severe diarrhea. gross necropsy lesions consisted of scattered pinpoint white foci throughout the liver and spleen. a massive, purulent bronchopneumonia was found also. direct fluorescent antibody tests and culture of spleen and liver samples confirmed a diagnosis of tularemia. | 1986 | 3702338 |
| peripheral blood leukocyte counts, erythrocyte sedimentation rate and c-reactive protein in tularemia caused by the type b strain of francisella tularensis. | the behavior of leukocytes, erythrocyte sedimentation rate (esr) and c-reactive protein (crp) in tularemia caused by type b of francisella tularensis was analyzed in different clinical forms and severities of disease in 101 adult tularemia patients. the mean leukocyte count was 8.3 x 10(9)/l and the leukocyte differential count was also usually normal. the behavior of leukocytes was similar in different clinical forms and severities of tularemia. the changes in differential counts were milder th ... | 1986 | 3710592 |
| [effect of the immunization of rats with tularemia vaccine on the number of cytogenetic disorders in somatic cells induced by cytostatics]. | cytogenetic disturbances due to cytostatic preparations--cyclophosphamide and methylnitrosourea--applied as single or ten-times administrations in different doses have been studied for rats immunized with tularemia live dried vaccine. it is established that with the application of these preparations to immunized animals the quantity of chromosomal aberrations in myelokaryocytes decreased from 1.4 to 2.2 times, compared with that in non-immunized animals. | 1986 | 3715978 |
| [possible mutagenic action of a tularemia vaccine]. | no increase in the number of chromosome aberrations in the bone marrow cells of the wistar rats was observed on the 1st, 2nd, 7th and 15th days after epidermal and intradermal immunization by tularemic live vaccine. subcutaneous injection of great quantities of tularemic microbic cells which were not used in practice increased the number of cells with chromosome aberrations only on the second day. | 1986 | 3750405 |
| [purine and pyrimidine metabolism in francisella tularensis]. | the assimilation and mutual transformation of exogenous purine and pyrimidine bases and their nucleosides in the known subspecies of f. tularensis have been studied by means of radio-labeled compounds. the possibility of using the specific features of the metabolism of these compounds in f. tularensis, established in this study, for taxonomy and differential diagnosis has been demonstrated. | 1986 | 3751405 |
| histopathology of human lymph node tularemia caused by francisella tularensis var palaearctica. | histopathology of tularemia, caused by type-b strain, tuberculosis, and sarcoidosis were compared in lymph node biopsy specimens from ten patients with tularemia, 26 with tuberculosis, and 14 with sarcoidosis. in very early tularemia there were only reactive changes without necrosis. abscess necrosis with or without epithelioid cell reaction was observed during the second week and caseous necrosis during the fourth week. argyrophil fibers were absent from necrotic lesions in tularemia, but, ofte ... | 1986 | 3753568 |
| [enhanced antitumor resistance in rats immunized with a tularemia vaccine]. | it is established that rat immunization with tularemia living vaccine inhibits pliss lymphosarcoma growth and increases the life duration to tumour bearing animals. in tests with zajdela ascitic hepatoma in 1/3 of the immunized animals ascites were not formed and the rats lived 150 days before they were killed. | 1986 | 3753929 |
| isolation of francisella tularensis from blood. | the isolation of francisella tularensis from blood culture is extremely rare; a review of the literature produced only five documented cases. however, over a recent 17-month period we saw four cases of tularemia in which the organism was isolated in blood culture. the clinical presentations of our patients and those reported previously were very similar. most of the patients had a significant underlying disease and presented with the typhoidal form of tularemia. furthermore, all our patients had ... | 1986 | 3760138 |
| tularemic meningitis in a child with mononuclear pleocytosis. | 1986 | 3763424 | |
| francisella tularensis meningitis: a rare clinical entity. | 1986 | 3772171 | |
| fatty acid distribution in the phospholipids of francisella tularensis. | francisella tularensis, lvs (live vaccine strain) grown in a chemically defined medium was found to have a lipid content of 21% by dry weight. the two major phospholipids were identified as phosphatidylethanolamine (pe; 76%) and phosphatidylglycerol (pg; 24%) by thin layer chromatographic analysis, staining characteristics and quantitative chemical analyses of fatty acid, phosphate and glycerol constituents. pe contained a high proportion of 24:0 fatty acid, with lesser amounts of 24:1, 22:0 and ... | 1986 | 3796231 |
| factors associated with a poor outcome in tularemia. | to identify the factors associated with a poor outcome, we reviewed the records of 28 patients with tularemia diagnosed between 1974 and 1984. most of the patients were men between the ages of 35 and 45 years, who presented with ulceroglandular tularemia. twelve patients had the anticipated rapid response to therapy, with resolution of their presenting symptoms within one week (group a). surprisingly, the majority (16 [58%] of 28) had a more prolonged or fatal illness (group b). group b patients ... | 1987 | 3813743 |
| [effect of a live tularemia vaccine on chemical mutagenesis in white rats]. | the influence of immunization with tularemic live dry vaccine applied singularly to wistar rats skin on mutagenicity induced by cyclophosphamide, methylnitrosourea, benzo (a) pyrene, chloroprene and tetrachlorbutane was studied. the chemical compounds indicated were injected intraperitoneally at doses equal to one fifth of ld50 in 15 days after vaccination. the same doses of these chemicals were applied to intact rats (controls). metaphase plates were prepared from rat bone marrows by known meth ... | 1985 | 3840760 |
| a family outbreak of tularemia. | a family cluster of tularemia is described. in a family of three members different clinical type of the disease occurred after having been exposed to a sick wild hare. from the hare kidney francisella tularensis type 1 was isolated. pneumonic, typhoid-like tularemia occurred in the father who inhaled hare skin hairs and an ulceroglandular form in the mother and in the child who had direct contact with the animal. | 1985 | 3842118 |
| francisella tularensis. | francisella tularensis is an infection acquired from animals. although the pathogen is not a cause of nosocomial infections, it is a major hazard to workers in the clinical microbiology laboratory and could easily become a problem for the infection control officer in this setting. the organism can be cultured from many sites but is difficult to recover unless the appropriate media are used. a number of clinical syndromes are caused by this pathogen. most are characterized by an ulceration and re ... | 1985 | 3850862 |
| weight reduction of thymus and depletion of lymphocytes of t-dependent areas in peripheral lymphoid tissues of mice infected with francisella tularensis. | when balb/c mice (young and adult animals of both sexes) were infected intraperitoneally with 10(3) viable cells of francisella tularensis (10(2) 50% lethal dose), all mice in these groups died on day 4. reductions in thymus weights and in numbers of thymic cortex lymphocytes were observed in all the groups, but the decline was not so severe in the young females. increases of plasma corticosterone in the adult males began 1 day after infection, but in the young females, the levels did not increa ... | 1985 | 3875562 |
| interleukin 2 production in whole blood culture: a rapid test of immunity to francisella tularensis. | the measurement of interleukin 2 from antigen-stimulated whole blood culture supernatants was used to detect cell-mediated immunity in subjects sensitized against francisella tularensis. the amount of interleukin 2 produced differentiated a positive immune reaction sensitively and reliably in a 24-h culture. whole blood culturing is an easy method for producing interleukin 2. | 1985 | 3875626 |
| long-lasting cell-mediated immunity induced by a live francisella tularensis vaccine. | the lymphocyte stimulation test was used to estimate specific cell-mediated immunity after vaccination with the live vaccine strain of francisella tularensis. nonvaccinated individuals and individuals vaccinated 1, 5 to 6, 7 to 8, and 9 years previously were tested. lymphocytes from most vaccinees responded to an antigen preparation of the vaccine strain, and those vaccinated 9 years before testing responded to a similar extent as did vaccines in the other groups. a new technique was developed t ... | 1985 | 3878364 |
| tularemia: a 30-year experience with 88 cases. | drawing upon our experience with 88 cases and a survey of the english literature, we reviewed the clinical, pathophysiological, and epidemiological aspects of tularemia. tularemia can be thought of as two syndromes--ulceroglandular and typhoidal. this dichotomy simplifies earlier nomenclature and emphasizes the obscure typhoidal presentation. clinical manifestations suggest that the two syndromes reflect differences in host response. in ulceroglandular tularemia the pathogen appears to be well c ... | 1985 | 3892222 |
| [effect of delayed hypersensitivity due to staphylococcus or bcg vaccine on the sensitivity of animals to infection with heterologous bacteria or influenza virus]. | experiments on mice of different strains have demonstrated that sensitization with bcg vaccine slightly increases resistance to infection with francisella tularensis, escherichia coli 819 and influenza a2 virus in mice of those strains which are capable of developing a high level of delayed hypersensitivity (dh). on the contrary, sensitization with staphylococcus aureus b-243 decreases this resistance. a sharp increase in resistance to infection has been achieved in sensitized animals receiving ... | 1985 | 3901628 |