Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| e449x mutation in the thyroid hormone receptor beta associated with autoimmune thyroid disease and severe neuropsychomotor involvement. | to report the clinical and molecular aspects of a patient with a diagnosis of resistance to thyroid hormone (rth) harboring the e449x mutation associated with autoimmune thyroid disease and severe neuropsychomotor retardation. | 2008 | 19169471 |
| a novel mutation of thyroid hormone receptor beta (i431v) impairs corepressor release, and induces thyroid hormone resistance syndrome. | resistance to thyroid hormone (rth) is a rare disorder characterized by variable tissue hyporesponsiveness to thyroid hormone, usually caused by mutations in the thyroid hormone receptor beta (trbeta). we describe a large brazilian family harboring a novel mutation affecting trbeta gene and inducing rth. a 14-year-old girl was found to have elevated free t4 and free t3 plasma concentrations in coexistence with unsuppressed tsh and a questionable goiter. the diagnosis of rth was verified by ident ... | 2008 | 19169485 |
| myelotoxicity of preoperative chemoradiotherapy is a significant determinant of poor prognosis in patients with t4 esophageal cancer. | currently, preoperative chemoradiotherapy followed by surgery is the only promising strategy for patients with t4 esophageal cancer. this study retrospectively analyzed the prognostic factors in patients with curatively resected cancer after chemoradiotherapy. | 2009 | 19170110 |
| amelioration of metformin-induced hypothyroidism by withania somnifera and bauhinia purpurea extracts in type 2 diabetic mice. | an investigation was carried out to reveal the possible ameliorative role of two plant extracts on an antidiabetic drug-induced hypothyroidism in type 2 diabetic animals. dexamethasone (1.0 mg/kg, i.m.) administration caused hyperglycemia with a parallel increase in renal lipid peroxidation (lpo), relative risk ratio (rr), and the concentrations of serum insulin; total cholesterol (tc); low-density lipoprotein cholesterol (ldl-c); very low-density lipoprotein cholesterol (vldl-c) and triglycerid ... | 2009 | 19170137 |
| tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting nf-kappab and jnk signaling. | recent research has focused on soluble oligomeric assemblies of beta-amyloid peptides (abeta) as the proximate cause of neuroinflammation, synaptic loss, and the eventual dementia associated with alzheimer's disease (ad). in this study, tripchlorolide (t4), an extract of tripterygium wilfordii hook. f (twhf), was studied as a novel agent to suppress neuroinflammatory process in microglial cells and to protect neuronal cells against microglia-mediated oligomeric abeta toxicity. t4 significantly a ... | 2009 | 19170180 |
| real-time monitoring of the activity and kinetics of t4 polynucleotide kinase by a singly labeled dna-hairpin smart probe coupled with lambda exonuclease cleavage. | we describe a novel method for real-time monitoring of the activity and kinetics of t4 polynucleotide kinase (pnk) by use of a singly fluorophore-labeled dna-hairpin smart probe (sp) coupled with lambda exonuclease (lambda exo) cleavage. the method was performed in a sealed reaction tube and offered more sensitive, fast, high-throughput, and cost-effective detection. the sp was designed with a fluorophore at the 3'-end, and the fluorescence was quenched by a ggg-triplet at the 5'-end without any ... | 2009 | 19170527 |
| metachronous hepatic metastases from gastric carcinoma: a multicentric survey. | the treatment of hepatic metastases from gastric cancer is controversial, due to biologic aggressiveness of the disease. | 2009 | 19171450 |
| diffuse hair loss in an adult female: approach to diagnosis and management. | telogen effluvium (te) is the most common cause of diffuse hair loss in adult females. te, along with female pattern hair loss (fphl) and chronic telogen effluvium (cte), accounts for the majority of diffuse alopecia cases. abrupt, rapid, generalized shedding of normal club hairs, 2-3 months after a triggering event like parturition, high fever, major surgery, etc. indicates te, while gradual diffuse hair loss with thinning of central scalp/widening of central parting line/frontotemporal recessi ... | 2009 | 19172026 |
| survival impact of nodal disease in hard palate and maxillary alveolus cancer. | evaluate the impact of primary site stage and cervical metastasis on the survival of patients with squamous cell carcinoma (scc) of the hard palate or maxillary alveolus. | 2009 | 19172612 |
| optical tweezers experiments resolve distinct modes of dna-protein binding. | optical tweezers are ideally suited to perform force microscopy experiments that isolate a single biomolecule, which then provides multiple binding sites for ligands. the captured complex may be subjected to a spectrum of forces, inhibiting or facilitating ligand activity. in the following experiments, we utilize optical tweezers to characterize and quantify dna binding of various ligands. high mobility group type b (hmgb) proteins, which bind to double-stranded dna, are shown to serve the dual ... | 2009 | 19173290 |
| [prognostic implication of common bile duct infiltration in adenocarcinoma of the ampulla of vater after pancreaticoduodenectomy]. | to investigate the prognostic implication of common bile duct infiltration in the adenocarcinoma of the ampulla of vater after panreaticoduodenectomy. | 2008 | 19173811 |
| [thyroid disorders and childhood rheumatic diseases]. | the relationship between thyroid dysfunction and autoimmune diseases has mainly been described in adults. the aim of this study was to analyse the prevalence and characteristics of thyroid abnormalities in children with rheumatic diseases. | 2009 | 19174120 |
| review of 120 anal cancer patients. | chemoradiotherapy is the mainstay of treatment for the majority of patients with anal cancer, with abdominoperineal resection reserved for salvage. the purpose of this study was to evaluate our results after radiotherapy with or without chemotherapy, and/or surgery in terms of overall survival and colostomy free survival in patients with anal cancer. | 2009 | 19175651 |
| clinical evaluation of a novel liquid formulation of l-thyroxine for once daily treatment of dogs with hypothyroidism. | a liquid solution of levothyroxine (l-t4) is available for treatment of canine hypothyroidism. | 2009 | 19175719 |
| phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy. | both induction chemotherapy followed by irradiation and concurrent chemotherapy and radiotherapy have been reported as valuable alternatives to total laryngectomy in patients with advanced larynx or hypopharynx cancer. we report results of the randomized phase 3 trial 24954 from the european organization for research and treatment of cancer. | 2009 | 19176454 |
| free-solution label-free detection of alpha-crystallin chaperone interactions by back-scattering interferometry. | we report the quantitative, label-free analysis of protein-protein interactions in free solution within picoliter volumes using backscatter interferometry (bsi). changes in the refractive index are measured for solutions introduced on a pdms microchip allowing determination of forward and reverse rate constants for two-mode binding. time-dependent bsi traces are directly fit using a global analysis approach to characterize the interaction of the small heat-shock protein alpha-crystallin with two ... | 2009 | 19178288 |
| accuracy of impression techniques for implants. part 2 - comparison of splinting techniques. | the aim of this study was to compare splinting techniques for impression copings of osseointegrated implants with different angulations. | 2009 | 19178624 |
| a phase iii randomised trial of lv5fu2 + irinotecan versus lv5fu2 alone in adjuvant high-risk colon cancer (fnclcc accord02/ffcd9802). | this multicenter adjuvant phase iii trial evaluated the addition of irinotecan to lv5fu2 in colon cancer patients at high risk of relapse. | 2009 | 19179549 |
| [thyroid-induced hyperthyroidism yin-deficiency model of rats]. | to establish a rat model of hyperthyroidism yin-deficiency. | 2008 | 19180970 |
| dual-phase 99mtc-mibi parathyroid imaging reveals synchronous parathyroid adenoma and papillary thyroid carcinoma: a case report. | the possibility of a coincidental appearance of hyperparathyroidism and thyroid cancer is not often considered because of its low incidence. here, we present a case of a 49-year-old woman with a parathyroid adenoma coexisting with two sites of papillary thyroid carcinoma. dual-phase 99mtc-methoxyisobutylisonitrile (mibi) parathyroid imaging before the operation correctly visualized the site of the parathyroid adenoma. in addition, two papillary thyroid carcinomas showed faint uptake of 99mtc-mib ... | 2008 | 19181586 |
| priming with rocuronium to accelerate the onset time of cisatracurium during intubation. | the priming technique, in which a small dose of nondepolarizing muscle relaxant is administered 3-6 minutes before giving the intubation dose, can speed up the onset of muscle relaxation in patients with paralysis during intubation. we investigated the priming technique and compared 2 different priming agents (rocuronium and cisatracurium) at a priming time of 3 minutes and its effect on decreasing the onset time of cisatracurium. | 2009 | 19181592 |
| induction chemoradiotherapy facilitates radical resection of t4 non-small cell lung cancer invading the spine. | we evaluated the outcome, long-term results, and factors affecting outcome of induction chemoradiotherapy followed by surgical resection for t4 non-small cell lung cancer invading the spine. | 2009 | 19185167 |
| isolation and genotyping of potentially pathogenic acanthamoeba strains from dust sources in iran. | opportunistic free-living amoebae of the acanthamoeba genus present genotypes/strains that are causative agents of acanthamoeba keratitis (ak), with genotype t4 related to most ak cases worldwide. in order to prove that exposure to dirt and dust could be an important risk factor for contact lens wearers in iran, 13 strains isolated from dust samples in this area were classified at the genotype level. results revealed the presence of t4, t5 and t11 genotypes within these samples. to our knowledge ... | 2009 | 19185896 |
| uva generates pyrimidine dimers in dna directly. | there is increasing evidence that uva radiation, which makes up approximately 95% of the solar uv light reaching the earth's surface and is also commonly used for cosmetic purposes, is genotoxic. however, in contrast to uvc and uvb, the mechanisms by which uva produces various dna lesions are still unclear. in addition, the relative amounts of various types of uva lesions and their mutagenic significance are also a subject of debate. here, we exploit atomic force microscopy (afm) imaging of indi ... | 2009 | 19186150 |
| thoracic epidural analgesia in post-thoracotomy patients: comparison of three different concentrations of levobupivacaine and sufentanil. | relative effects of dosage, volume and concentration of local anaesthetics used for postoperative thoracic epidural analgesia are still under debate. in this randomized, prospective, double-blinded study, we evaluated the incidence of side-effects such as changes in arterial pressure, postoperative nausea, vomiting, and pruritus in patients admitted for thoracic surgery during continuous thoracic epidural infusion using levobupivacaine and sufentanil mixture in three different volumes. | 2009 | 19189982 |
| developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in cd-1 mice. | organophosphorus insecticides, as chlorpyrifos (cpf), are widely used in agriculture and against household pests; these compounds receive an increasing consideration as potential endocrine disrupters. the aim of the present study was to examine the potential short- and long-term effects of cpf on thyroid and adrenal glands in cd1 mice following exposure at dose levels not inducing brain acetyl cholinesterase (ache) inhibition, during gestational and/or postnatal vulnerable phases. pregnant dams ... | 2009 | 19190125 |
| multifrequency electron spin resonance spectra of a spin-labeled protein calculated from molecular dynamics simulations. | multifrequency electron spin resonance (esr) spectra provide a wealth of structural and dynamic information about the local environment of the spin label and, indirectly, about the spin-labeled protein. relating the features of the observed spectra to the underlying molecular motions and interactions is, however, challenging. to make progress toward a rigorous interpretation of esr spectra, we perform extensive molecular dynamics (md) simulations of fully solvated t4 lysozyme, labeled with the s ... | 2009 | 19191603 |
| tsh-based protocol, tablet instability, and absorption effects on l-t4 bioequivalence. | fda guidance for pharmacokinetic (pk) testing of levothyroxine (l-t(4)) for interbrand bioequivalence has evolved recently. concerns remain about efficacy and safety of the current protocol, based on pk analysis following supraphysiological l-t(4) dosing in euthyroid volunteers, and recent recalls due to intrabrand manufacturing problems also suggest need for further refinement. we examine these interrelated issues quantitatively, using simulated what-if scenarios testing efficacy of a tsh-based ... | 2009 | 19191742 |
| evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study. | to objectively compare the mood profiles of users of malaria chemoprophylaxis regimens (atovaquone-proguanil, chloroquine-proguanil, doxycycline, or mefloquine) in a group of nonimmune tourists to sub-saharan africa. | 2009 | 19192127 |
| neoadjuvant chemoradiotherapy with 5-fluorouracil by bolus. | neoadjuvant chemoradiotherapy (ct-rt) with continuous infusion (c.i.) 5-fluorouracil (5-fu) before resection of high-risk rectal cancer improves overall survival (os) and pelvic control. since the presence of cardiomiopathy may contraindicate c.i. of 5-fu, an alternative regimen of 5-fu ct-rt was prospectively studied in these patients. | 2008 | 19192666 |
| effects of modified ultrafiltration on coagulation as measured by the thromboelastograph. | hemodilution during cardiopulmonary bypass (cpb) continues to be a cause of morbidity associated with coagulation dysfunction, bleeding, and allogeneic blood transfusion. clot formation and strength have been shown to impact bleeding and transfusions. strategies to reduce hemodilution may be negated based on the course of the cardiac procedure itself. modified ultrafiltration (muf) is commonly used in pediatric cardiac surgery; however, it is not well accepted in adult surgery. this study aimed ... | 2008 | 19192750 |
| prostate cancer diagnosis: should patients with prostate specific antigen >10ng/ml have stratified prostate biopsy protocols? | trans-rectal ultrasound (trus) guided systematic prostate biopsy is a standard tool in prostate cancer (cap) diagnosis. extended biopsy techniques using 10-12 cores are the norm. controversy exists on extended trus biopsy in men with psa>10ng/ml. we evaluated cancer detection rates on an individual core basis, to stratify prostate biopsy protocols based on psa levels. | 2009 | 19193497 |
| treatment of t3 gallbladder cancer. | until recently, advanced stage gallbladder cancer has been viewed with great pessimism and many patients abandoned as without potentially curative treatment option. recent results have significantly improved due to a number of advances. improvements in radiologic staging including positron emission tomography now allow selection of patients with disease treatable by local regional resection. with improvements in surgical and anesthetic techniques, aggressive surgery has proven t3 and t4 tumors t ... | 2009 | 19194769 |
| pelizaeus-merzbacher-like disease presentation of mct8 mutated male subjects. | pelizaeus-merzbacher disease is an x-linked hypomyelinatiing leukodystrophy. we report mutations in the thyroid hormone transporter gene mct8 in 11% of 53 families affected by hypomyelinating leukodystrophies of unknown aetiology. the 12 mct8 mutated patients express initially a pelizaeus-merzbacher-like disease phenotype with a latter unusual improvement of magnetic resonance imaging white matter signal despite absence of clinical progression. this observation underlines the interest of determi ... | 2009 | 19194886 |
| carbonic anhydrase ix in bladder cancer: a diagnostic, prognostic, and therapeutic molecular marker. | the objective of this study was to evaluate the role of carbonic anhydrase ix (caix) in urothelial carcinoma of the bladder. | 2009 | 19195047 |
| orbital metastasis as primary clinical manifestation of thyroid carcinoma--case report and literature review. | capillary thyroid carcinoma (ptc) is the most common neoplasm of thyroid. it usually grows slowly and is clinically indolent; although rare, its aggressive forms with local invasion or distant metastases can occur. metastatic thyroid carcinoma rarely involves the orbit. we reported an uncommon case of orbital metastasis of ptc. a 66-years-old woman presented proptosis of the right eye. the biopsy of the tumor in orbit revealed metastatic thyroid carcinoma. the ultrasensitive tsh level was 1,34 m ... | 2008 | 19197459 |
| a free-standing homing endonuclease targets an intron insertion site in the psba gene of cyanophages. | homing endonuclease genes are mobile elements that promote their duplication into cognate sites that lack the endonuclease gene [1, 2]. the homing endonuclease initiates this event through site-specific dna cleavage. copying of the endonuclease gene follows as a consequence of dna repair. a genome containing a homing endonuclease gene is subject to self-cleavage. protection is accomplished through dna sequence polymorphisms, as is the case in intronless homing of free-standing endonuclease genes ... | 2009 | 19200728 |
| inflammatory response to cardiopulmonary bypass with enoximone or steroids in patients undergoing myocardial revascularization: a preliminary report study. | recent reports have showed an antiinflammatory effect of phosphodiesterase iii inhibitors (pdei) in patients undergoing cardiopulmonary bypass (cpb). we sought to evaluate the immunological and hemodynamic response to enoximone and methylprednisolone in patients undergoing cabg. | 2009 | 19203563 |
| [complications of transoral laser surgery for malignant tumors of the larynx and hypopharynx]. | transoral dioxide laser resection of early tumors (tis, t1, t2) in the aerodigestive tract seems to be an established method of treatment. recently, large tumors (t3 and t4) have been treated by this surgical method too, and therefore it seems reasonable to assess the complication rates. | 2009 | 19205077 |
| [endocrine effects of antiepileptic drugs]. | both seizures and antiepileptic drugs may induce disturbances in hormonal system. regarding endocrine effects of anticonvulsants, an interaction of these drugs with gonadal, thyroid, and adrenal axis deserves attention. since majority of antiepileptic drugs block voltage dependent sodium and calcium channels, enhance gabaergic transmission and/or antagonize glutamate receptors, one may expect that similar neurochemical mechanisms are engaged in the interaction of these drugs with synthesis of hy ... | 2008 | 19205363 |
| cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma. | cortactin, fascin, and survivin have been documented in several human cancers and play important roles in tumor progression. we collected 57 surgical specimens, including esophageal squamous cell carcinomas (sqcc; 7 well-differentiated, 15 moderately differentiated, and 24 poorly differentiated), 3 dysplasias, and 8 normal esophageal tissues. tissue microarrays were constructed and the immunostaining scores for cortactin, fascin, and survivin were assessed. in 46 sqcc specimens, we examined the ... | 2009 | 19207554 |
| effects of combined interferon alpha and ribavirin therapy on thyroid functions in patients with chronic hepatitis c. | to determine the frequency of thyroid dysfunction in patients of chronic hepatitis c during treatment with interferon alpha-2b and ribavirin therapy. | 2009 | 19208310 |
| accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. | to characterize the hormonal milieu and adipose gene expression in response to catch-up growth (cug), a growth pattern associated with obesity and diabetes risk, in a mouse model of low birth weight (lbw). | 2009 | 19208909 |
| aluminium siting in the zsm-5 framework by combination of high resolution 27al nmr and dft/mm calculations. | the al siting in the zsm-5 zeolite was investigated by (27)al 3q mas nmr spectroscopy and qm/mm calculations. it was found that the occupation of the framework t-sites by al and the concentration of al in these t-sites are neither random nor controlled by a simple rule. they both depend on the conditions of the zeolite synthesis. at least 12 out of the 24 distinguishable framework t-sites of zsm-5 are occupied by al in the set of the investigated zeolite samples. a partial identification of the ... | 2009 | 19209368 |
| detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hypothyroidism. | premature, very-low-birth-weight female twins were diagnosed with congenital hypothyroidism (ch). thyroid hormone antibodies (thab) directed against triiodothyronine (t3) and thyroxine (t4) of both the igm and igg class were detected in both twins. at age 10 months, a rise in thyroid stimulating hormone (tsh) occurred in both infants and measurement of thab at the same time revealed the appearance of igm-t4 and igg-t4 and an increase in igg-t3 levels in twin 1 (permanent ch), and with a slight i ... | 2008 | 19209623 |
| thyroxine as a stimulator of liver regeneration after partial hepatectomy: an experimental animal study. | twenty six male albino rats were divided into a control group (6rats) (g) exposed to sham operation and two experimental groups (g1 & g2) of 10 rats each. 2/3 partial hepatectomy (ph) was performed in g1 and t4 was administered orally in a dose of 4 mg/kg 10 days prior to ph in g2. animals were sacrificed 24 hours following ph and sham operation. liver sections were immunohistochemically stained for anti-cyclin d1 & anti-vegf antibodies. positive reaction was in the nuclei of hepatocytes and in ... | 2008 | 19209768 |
| the impact of stress and anxiety on the pressure pain threshold of myofascial pain patients. | the purpose of this study was to evaluate the influence of stress and anxiety on the pressure pain threshold (ppt) of masticatory muscles and on the subjective pain report. forty-five women, students, with mean age of 19.75 years, were divided into two groups: group 1:29 presenting with masticatory myofascial pain (mfp), according to the research diagnostic criteria for temporomandibular disorders and group 2: 16 asymptomatic controls. an electronic algometer registered the pain thresholds on fo ... | 2009 | 19210679 |
| polybrominated diphenyl ether (pbde) concentrations in house dust are related to hormone levels in men. | despite documented widespread human exposure to polybrominated diphenyl ethers (pbdes) through dietary intake and contact with or inhalation of indoor dust, along with growing laboratory evidence for altered endocrine function following exposure, human studies of pbde exposure and endocrine effects remain limited. we conducted a preliminary study within an ongoing study on the impact of environmental exposures on male reproductive health. we measured serum hormone levels and pbde concentrations ... | 2009 | 19211133 |
| prospective study evaluating postoperative radiotherapy plus 2-year androgen suppression for post-radical prostatectomy patients with pathologic t3 disease and/or positive surgical margins. | to determine the efficacy of a combined approach of postoperative radiotherapy (rt) plus 2-year androgen suppression (as) for patients with pathologic t3 disease (pt3) and/or positive surgical margins (psm) after radical prostatectomy (rp). | 2009 | 19211197 |
| capecitabine initially concomitant to radiotherapy then perioperatively administered in locally advanced rectal cancer. | to evaluate the impact of neoadjuvant capecitabine, concomitant to radiotherapy, followed by capecitabine monotherapy, in operable locally advanced rectal cancer (larc) by measuring pathologic response and conservative surgery rate, toxicity profile, and disease-free survival (dfs). | 2009 | 19211200 |
| intra-aortic balloon pump induced pulsatile perfusion reduces endothelial activation and inflammatory response following cardiopulmonary bypass. | intra-aortic balloon pump (iabp)-induced pulsatile perfusion has demonstrated that it can preserve organ function during cardiopulmonary bypass (cpb). we evaluated the role of iabp pulsatile perfusion on endothelial response. | 2009 | 19211261 |
| design of multiplex pcr primers using heuristic algorithm for sequential deletion applications. | the sequential deletion method is commonly applied to locate the functional domain of a protein. unfortunately, manually designing primers for multiplex polymerase chain reaction (pcr) is a labor-intensive task. in order to speed up the experimental procedure and to improve the efficiency of producing pcr products, this paper proposes a multiplex pcr primers (mpcrps) designer to design multiple forward primers with a single 3'-utr reverse primer for extracting various n-terminal truncated mutant ... | 2009 | 19211306 |
| hepatobiliary disposition of thyroid hormone in mrp2-deficient tr- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism. | the hepatobiliary disposition of thyroxine (t4) was evaluated in groningen yellow transport deficient (tr(-)) rats lacking functional multidrug resistance-associated protein 2 (mrp2; abcc2). male wistar and tr(-) rats were dosed orally (4 days) with phenobarbital (pb; 100 mg/kg) or dmp 904 (200 mg/kg), after which t4 homeostasis and hepatic cytochromes p450, udp-glucuronosyltransferase, xenobiotic transporters, and t4 glucuronidation were determined. serum concentrations of t4 were approximately ... | 2009 | 19211616 |
| comprehensive study on the prognostic role of osteopontin expression in oral squamous cell carcinoma. | osteopontin is a tumor-associated protein that promotes tumor development and metastasis. the preoperative blood samples of 94 oral squamous cell carcinoma (oscc) patients and 28 healthy individuals were analyzed for plasma osteopontin levels, and another 256 paraffin-embedded oscc specimens were analyzed by osteopontin immunostaining. the patients with advanced tumor (t) stage (t3/t4 vs. t1/t2) and positive nodal (n) status had significantly higher plasma levels of osteopontin (both p<0.001). p ... | 2009 | 19213594 |
| variation in the distribution of trace elements in renal cell carcinoma. | the development of cancer is a complex, multistage process during which a normal cell undergoes genetic changes that result in phenotypic alterations and in the acquisition of the ability to invade other sites. inductively coupled plasma optical emission spectroscopy was used to estimate the contents of al, ca, cd, cr, cu, fe, k, mg, mn, na, p, pb, and zn in healthy kidney and renal cell carcinoma (rcc), and significant differences were found for all elements. along with the progression of the m ... | 2009 | 19214399 |
| effect of hypophysectomy and growth hormone replacement on hypothalamic growth hormone-releasing factor messenger ribonucleic acid levels. | abstract the mechanisms by which the pituitary gland, and growth hormone (gh) in particular, affect growth hormone-releasing factor (grf) gene expression have been addressed using the technique of in situ hybridization. anatomically matched sections through the mediobasal hypothalamus of control and hypophysectomized male rats, with or without gh hormone replacement, were analysed to obtain information on grf mrna levels within the arcuate nucleus and around the ventromedial hypothalamus. hypoph ... | 1991 | 19215536 |
| rna processing and decay in bacteriophage t4. | bacteriophage t4 is the archetype of virulent phage. it has evolved very efficient strategies to subvert host functions to its benefit and to impose the expression of its genome. t4 utilizes a combination of host and phage-encoded rnases and factors to degrade its mrnas in a stage-dependent manner. the host endonuclease rnase e is used throughout the phage development. the sequence-specific, t4-encoded regb endoribonuclease functions in association with the ribosomal protein s1 to functionally i ... | 2009 | 19215770 |
| [change in surgical treatment of esophageal cancer in the course of the past 50 years]. | oesophageal surgery--apart from sporadic attempts--has a history of about fifty years. it was traditionally fallen into the realm of thoracic surgery developing collaterally and accomplished by the development of anaesthesiology and perioperative care. initial surgery of the oesophagus begun by procedures aimed at tumours of the lower third and those of the gastroesophageal junction and the cardia. surgical procedures for esophageal cancer became widespread by 1970's, leading to establishment of ... | 2009 | 19218161 |
| isolation and characterization of metalloproteases with a novel domain structure by construction and screening of metagenomic libraries. | small-insert metagenomic libraries from four samples were constructed by a topoisomerase-based and a t4 dna ligase-based approach. direct comparison of both approaches revealed that application of the topoisomerase-based method resulted in a higher number of insert-containing clones per microg of environmental dna used for cloning and a larger average insert size. subsequently, the constructed libraries were partially screened for the presence of genes conferring proteolytic activity. the functi ... | 2009 | 19218412 |
| hypothyroid hashimoto's thyroiditis with scintigraphic and color flow doppler sonography features mimicking a hot nodule. | we report a 59-year-old woman who had hashimoto's thyroiditis (ht) with hypothyroidism. a solid hypervascularized nodule in the right lobe was detected by color flow doppler sonography (cfds). thyroid (99m)tc pertechnetate scintigraphy revealed a hot area in the right lobe. after three months, thyroid function tests also revealed hypothyroidism and (131)i scintigraphy was similar to the previous scintigraphy. no nodular or hypervascularized lesion in the right lobe could be identified at the six ... | 2009 | 19218774 |
| the prevalence of thyroid dysfunction in elderly cardiology patients with mild excessive iodine intake in the urban area of são paulo. | to evaluate the prevalence of thyroid dysfunction in elderly cardiac patients in an outpatient setting. | 2009 | 19219319 |
| psychiatric morbidity and comorbidity in different vestibular vertigo syndromes. results of a prospective longitudinal study over one year. | high rates of coexisting vestibular deficits and psychiatric disorders have been reported in patients with vertigo. hence, a causal linkage between the vestibular system and emotion processing systems has been postulated. the aim of this study was to evaluate the impact of vestibular function and vestibular deficits as well as preexisting psychiatric pathologies on the course of vestibular vertigo syndromes over 1 year. | 2009 | 19221849 |
| effects of temperature on the fitness cost of resistance to bacteriophage t4 in escherichia coli. | resistance to predation, herbivory, or disease often comes at a cost such that resistant genotypes are competitively inferior to their sensitive counterparts in the absence of predators, herbivores, or pathogens. the effects of this trade-off on natural populations depend on its sensitivity to environmental changes. we used escherichia coli and bacteriophage t4 as a model predator/prey system to study the effects of temperature on the cost of resistance. an array of independent t4-resistant muta ... | 2009 | 19222568 |
| penicilliols a and b, novel inhibitors specific to mammalian y-family dna polymerases. | penicilliols a (1) and b (2) are novel 5-methoxy-3(2h)-furanones isolated from cultures of a fungus (penicillium daleae k.m. zalessky) derived from a sea moss, and their structures were determined by spectroscopic analyses. these compounds selectively inhibited activities of eukaryotic y-family dna polymerases (pols) (i.e., pols eta, iota and kappa), and compound 1 was a stronger inhibitor than compound 2. among mammalian y-family pols, mouse pol iota activity was most strongly inhibited by comp ... | 2009 | 19223184 |
| substrate metabolism during exercise in the spinal cord injured. | the primary aim of the study was to examine substrate metabolism during combined passive and active exercise in individuals with spinal cord injury (sci). nine men and women with sci (mean age 40.6 +/- 3.4 years) completed two trials of submaximal exercise 1 week apart. two maintained a complete injury and seven had an incomplete injury. level of injury ranged from thoracic (t4-t6 and t10) to cervical (four c5-c6 and three c6-c7 injuries). during two bouts separated by 1 week, subjects completed ... | 2009 | 19224241 |
| experience-dependent regulation of trkb isoforms in rodent visual cortex. | within primary visual cortex (v1), brain-derived neurotrophic factor (bdnf) signaling through its high-affinity receptor trkb is important for normal development and experience-dependent plasticity. trkb is expressed in several alternatively spliced isoforms, including full-length trkb (trkb.fl), and several truncated isoforms (trkb.t1, trkb.t2, and trkb.t4) that lack the intracellular tyrosine kinase domain. these isoforms are important components of bdnf signaling, yet little is known about th ... | 2009 | 19224567 |
| mass spectrometric analysis of innovator, counterfeit, and follow-on recombinant human growth hormone. | we have performed a detailed characterization of recombinant human growth hormone that included the identification of the entire sequence with disulfide linkages as well as subtle modifications by a sensitive liquid chromatography coupled online with tandem mass spectrometry (lc-ms) approach using the accurate peptide mass (fticr ms) and sequence assignment (ms/ms measurement). the extent of oxidation, deamidation, and chain cleavages were measured by the ratio of peak areas of the nonmodified p ... | 2009 | 19224592 |
| beta1,3-galactosyltransferases-4/5 are novel tumor markers for gynecological cancers. | while the ca 125 and scc antigens are used as tumor markers for ovarian cancer and uterine cervical cancer, respectively, an effective marker for uterine corpus cancer has not been identified. we asked whether beta1,3-galactosyltransferase-4 and/or 5 (beta3gal-t4/t5) could serve as novel tumor markers for detecting gynecological carcinomas, especially those of the uterine corpus. | 2009 | 19225246 |
| effects of propofol or etomidate on qt interval during electroconvulsive therapy. | because patients with major depression have an altered autonomic nervous system activity, the risk of arrhythmias and sudden cardiac death may be increased. in addition, electroconvulsive therapy (ect) may cause an acute rise in qt dispersion, which may predispose to arrhythmias. in this study, we investigated the effects of propofol or etomidate on the corrected qt (qtc) interval during ect in patients with major depression. | 2009 | 19225403 |
| the highly related lim factors, lmo1, lmo3 and lmo4, play different roles in the regulation of the pituitary glycoprotein hormone alpha-subunit (alpha gsu) gene. | lmo1, lmo3 and lmo4 were cloned from the adult porcine pituitary cdna library. amino acid sequences of porcine lmo1, lmo3 and lmo4 were highly conserved among mammalian species. transfection assay of the pituitary-derived cell line l beta t2 was carried out using the pituitary alpha gsu (glycoprotein hormone alpha-subunit) promoter (-1059/+12 b) fused to pseap2-basic vector as a reporter gene. the results demonstrated that, whereas lmo4 showed no apparent effect, alpha gsu promoter activity was ... | 2009 | 19228115 |
| prognostic impact of human epidermal growth factor-like receptor 2 and hormone receptor status in inflammatory breast cancer (ibc): analysis of 2,014 ibc patient cases from the california cancer registry. | inflammatory breast cancer (ibc) is an aggressive form of breast cancer associated with overexpression of her2/neu (human epidermal growth factor-like receptor 2 (her2)) and poor survival. we investigated survival differences for ibc patient cases based on hormone receptor status and her2 receptor status using data from the california cancer registry, as contrasted with locally advanced breast cancer (labc), metastatic breast cancer (mbc) and non-t4 breast cancer. | 2009 | 19228416 |
| the tail sheath structure of bacteriophage t4: a molecular machine for infecting bacteria. | the contractile tail of bacteriophage t4 is a molecular machine that facilitates very high viral infection efficiency. its major component is a tail sheath, which contracts during infection to less than half of its initial length. the sheath consists of 138 copies of the tail sheath protein, gene product (gp) 18, which surrounds the central non-contractile tail tube. the contraction of the sheath drives the tail tube through the outer membrane, creating a channel for the viral genome delivery. a ... | 2009 | 19229296 |
| temporal patterns of fatigue predict pathologic response in patients treated with preoperative chemoradiation therapy for rectal cancer. | to investigate whether symptom burden before and during preoperative chemoradiation therapy (crt) for rectal cancer predicts for pathologic tumor response. | 2009 | 19231100 |
| surgical resection is justified in non-small cell lung cancer patients with node negative t4 satellite lesions. | the management of non-small cell lung cancer (nsclc) depends on the stage, with a satellite nodule in the same lobe being classified as t4 stage iiib even in node negative patients. controversy exists as to the optimal management of these patients. our objectives were to evaluate the outcomes in surgically resected patients with a t4 satellite lesion and to analyze the prognostic factors associated with outcome. | 2009 | 19231415 |
| survival and prognostic factors in a series of adults with medulloblastomas. | in this article, the authors report their experience in the management of adult patients with medulloblastoma at their institution to identify prognostic factors important for survival and disease control. | 2009 | 19231932 |
| a multistage chronobiologic intervention for the treatment of depression: a pilot study. | most antidepressant medications in current use have several disadvantages: a delayed therapeutic effect, side effects, stigmatization and concerns about safety for the developing fetus during pregnancy. several chronobiologic techniques which are free of these disadvantages were proposed as an alternative. the current article reports the design and the initial outcome results of a new chronobiologic multistage intervention (cmi) that is comprised of the following techniques: (i) partial sleep de ... | 2009 | 19232745 |
| retinoic acid effects on thyroid function of female rats. | retinoic acid is widely used in dermatological treatment and thyroid cancer management; however its possible side-effects on normal thyroid function remains unknown. we aimed to determine the effects of retinoic acid on thyroid function of adult female rats. | 2009 | 19233213 |
| prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma. | : the purpose of this study was to evaluate the prognostic value of magnetic resonance imaging (mri)-detected cranial nerve (cn) involvement in nasopharyngeal carcinoma (npc). | 2009 | 19235251 |
| [pendred syndrome among patients with hypothyroidism: genetic diagnosis, phenotypic variability and occurrence of phenocopies]. | pendred syndrome (omim274600) is one of the causes of congenital hypothyroidism due to thyroid dyshormonogenesis. it is an autosomal recessive disease classically characterized by dyshormonogenetic goitre and sensorineural deafness. it is caused by mutations in pds/slc26a4 gene encoding for pendrin--an anion transporter, mostly expressed in the thyroid gland and the inner ear. the thyroid impairment in pendred syndrome develops only in 80% of affected individuals in form of a euthyroid or hypoth ... | 2008 | 19235486 |
| thyreotropic effect of human chorionic gonadotropin (hcg) in mares at estrus. | the beta-subunits of thyroid stimulating hormone (tsh) and human chorionic gonadotropin (hcg) share a high homology, just like the ectodomains of their receptors, do. as a consequence, hcg was shown to exert a thyrotropic action in humans and hamsters. this study aimed to investigate whether hcg, used to induce ovulation, displays a thyrotropic effect in the equine species too. forty mares at estrus were divided in two groups; 20 were intravenously treated with sterile saline solution (nacl 0.9% ... | 2009 | 19235540 |
| effect of a bis-thiazolium compound on the biosynthesis of plasmodium falciparum phospholipids. | in the eukaryotic cell, phospholipids can be biosynthesized by two pathways, one from choline and the other one from ethanolamine. the functional effectiveness of each pathway depends on the type of the cell. thiazolium designed-drugs have shown, under in vivo conditions, antiplasmodial and antimalarial activities with inhibition of the phospholipids biosynthesis. this study aimed to discover the pathways involved in the biosynthesis of phospholipids in plasmodium and deduce the biochemical step ... | 2009 | 19235542 |
| is adjuvant chemotherapy beneficial to high risk stage ii colon cancer? analysis in a single institute. | colorectal carcinoma is the most common malignancy of the gastrointestinal tract. it remains controversial for adjuvant chemotherapy in patients with stage ii colon cancer. this study was designed to identify the risk factors of tumor recurrence in stage ii colon cancer. furthermore, the benefit of adjuvant chemotherapy for high-risk stage ii colorectal cancer will be investigated. | 2009 | 19238405 |
| isolation and characterization of bacteriophages for avian pathogenic e. coli strains. | to isolate and characterize bacteriophages, and to evaluate its lytic performance against avian pathogenic escherichia coli (apec) strains with high patterns of antibiotic resistance, in order to select phages for a therapeutic product to treat colibacillosis in chickens. | 2009 | 19239552 |
| evaluation of acceptability and use of lockable storage devices for pesticides in sri lanka that might assist in prevention of self-poisoning. | self-poisoning with pesticides is a major reason for high suicide rates in rural areas of many developing countries. safer storage of pesticides may be one means of prevention. we have conducted a study to assess the acceptability and use of lockable boxes for storing pesticides in rural sri lanka. | 2009 | 19239714 |
| surgical treatment of superior sulcus tumors: results and prognostic factors. | this study aims to investigate the treatment modalities and factors influencing survival in surgically treated superior sulcus tumors. | 2009 | 19241311 |
| microscopic pka analysis of glu286 in cytochrome c oxidase (rhodobacter sphaeroides): toward a calibrated molecular model. | as stringent tests for the molecular model and computational protocol, microscopic pk(a) calculations are performed for the key residue, glu286, in cytochrome c oxidase (cco) using a combined quantum mechanical/molecular mechanical (qm/mm) potential and a thermodynamic integration protocol. the impact of the number of water molecules in the hydrophobic cavity and protonation state of several key residues (e.g., his334, cu(b)-bound water, and prd(a3)) on the computed microscopic pk(a) values of g ... | 2009 | 19243111 |
| palladium-103 ophthalmic plaque radiation therapy for choroidal melanoma: 400 treated patients. | to describe 18 years of experience with palladium-103 ((103)pd) ophthalmic plaque brachytherapy. | 2009 | 19243829 |
| locally advanced rectal cancer: mr imaging in prediction of response after preoperative chemotherapy and radiation therapy. | to prospectively differentiate, at magnetic resonance (mr) imaging, patients with locally advanced nonmucinous rectal cancer who will respond to long-course chemotherapy and radiation therapy (crt) from those who will not respond, with histopathologic results as the reference standard. | 2009 | 19244043 |
| functional complementation of uvsx and uvsy mutations in the mediation of t4 homologous recombination. | bacteriophage t4 homologous recombination events are promoted by presynaptic filaments of uvsx recombinase bound to single-stranded dna (ssdna). uvsy, the phage recombination mediator protein, promotes filament assembly in a concentration-dependent manner, stimulating uvsx at stoichiometric concentrations but inhibiting at higher concentrations. recent work demonstrated that uvsx-h195q/a mutants exhibit decreased ssdna-binding affinity and altered enzymatic properties. here, we show that unlike ... | 2009 | 19244311 |
| advanced oral tongue cancer in a 22-year-old pregnant woman. | oral squamous cell carcinoma generally occurs in older men and is associated mostly with tobacco and alcohol as the primary risk factors. the incidence of oral squamous cell carcinoma in younger patients has increased. we report a case of a young woman, 25 weeks pregnant, who presented with stage iv carcinoma of the oral tongue. | 2009 | 19244959 |
| [postoperative analgesia with fentanyl combined with flurbiprofen axetil following gynecologic surgery for turnor]. | a to observe the analgesic effect of fentanyl combined with flurbiprofen axetil for postoperative analgesia after gynecologic surgery. | 2009 | 19246310 |
| prevalence of post-partum thyroiditis in liguria (italy): an observational study. | post-partum thyroiditis (ppt) is an autoimmune disorder occurring within the first year following delivery. a variable prevalence has been reported in different surveys. we prospectively evaluated ppt prevalence and outcome in a cohort of pregnant women living in a well-defined geographic area. | 2008 | 19246971 |
| bladder tumour staging: comparison of diffusion- and t2-weighted mr imaging. | the aim of this work was to evaluate the clinical feasibility of diffusion-weighted (dw) mri in detection and staging of urinary bladder tumour and to compare dw mri with the t(2)-weighted technique. one hundred and six patients with bladder tumour were prospectively included in our study. all patients were evaluated with mr imaging. we started with axial t(2)-weighted high resolution mr of the urinary bladder, then dw mri. two radiologists independently interpreted the mr images, and discrepanc ... | 2009 | 19247665 |
| bacterial populations in complementary foods and drinking-water in households with children aged 10-15 months in zanzibar, tanzania. | bacteria were quantified in samples of drinking-water and in two porridges prepared for infant-feeding [fortified instant soy-rice porridge (srp) and cooked porridge (lishe bora, lb)] in 54 households. bacterial numbers were measured again after the porridges had been held at room temperature for four hours (t4). findings were benchmarked against bacterial numbers in traditional complementary foods sampled from 120 households. total bacteria, coliform, and enterobacteriaceae counts were enumerat ... | 2009 | 19248647 |
| the evolution of management for inverted papilloma: an analysis of 200 cases. | to assess the evolution of management within one institution with the largest case series and longest clinical follow-up of ip to date in the literature and to compare this management with what has been recently presented in publication. | 2009 | 19248937 |
| dna delivery in vitro via surface release from multilayer assemblies with poly(glycoamidoamine)s. | localized controlled release of nucleic acid therapeutics could be an effective way to reduce the extracellular barriers associated with systemic delivery. herein, we have used the layer-by-layer film deposition approach to construct ultrathin multilayer assemblies for in vitro controlled release of plasmid dna (pdna). layer-by-layer assemblies containing alternate layers of cationic poly(l-tartaramidopentaethylenetetramine) (t4), and anionic pdna were fabricated. the film thickness and the abso ... | 2009 | 19249723 |
| radioactive iodine for hyperthyroidism in children and adolescents: referral rate and response to treatment. | radioactive iodine ((131)i) therapy is increasingly viewed as a safe and effective treatment for paediatric and adolescent hyperthyroidism. our objective was to estimate treatment response and its predictors and describe current referral practices for (131)i therapy. | 2009 | 19250263 |
| fermentative production of thymidine by a metabolically engineered escherichia coli strain. | thymidine is an important precursor in the production of various antiviral drugs, including azidothymidine for the treatment of aids. since thymidine-containing nucleotides are synthesized only by the de novo pathway during dna synthesis, it is not easy to produce a large amount of thymidine biologically. in order to develop a host strain to produce thymidine, thymidine phosphorylase, thymidine kinase, and uridine phosphorylase genes were deleted from an escherichia coli bl21 strain to develop b ... | 2009 | 19251902 |
| the effect of hormone replacement treatment on thrombin-activatable fibrinolysis inhibitor activity levels in patients with hashimoto thyroiditis. | hypothyroid patients have increased risk of cardiovascular diseases, and several mechanisms have been considered responsible in these patients. although, a few studies demonstrated fibrinolytic system changes in hypothyroid patients, there is no study demonstrating tafi activity in hypothyroid hashimoto's thyroiditis patients. the aim of this study was to evaluate tafi activity status and the effect of l thyroxin hormone replacement treatment on fibrinolytic system in this patient group. | 2009 | 19252348 |
| neoadjuvant chemotherapy and surgery for esophageal adenocarcinoma: prognostic value of circumferential resection margin and stratification of n1 category. | in the uk, it is standard practice to treat esophageal adenocarcinoma with neoadjuvant chemotherapy (no radiation) and surgery. we examined the prognostic value of the status of the circumferential resection margin (crm) and stratification of the n1 category into 1-4 nodes or > or = 5 nodes. | 2009 | 19252949 |