Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| spinal cord blood flow and ischemic injury after experimental sacrifice of thoracic and abdominal segmental arteries. | spinal cord blood flow (scbf) after sacrifice of thoracoabdominal aortic segmental arteries (taasa) during thoracoabdominal aortic aneurysm (taaa) repair remains poorly understood. this study explored scbf for 72 h after sacrifice of all taasa. | 2008 | 18374592 |
| topographical considerations under video-scope guidance in the t3,4 levels sympathetic surgery. | anatomical variation of the sympathetic nervous system is known to be one of the main causes of failure and dissatisfaction after sympathetic surgery. however, there are only few reports on the descriptive analysis of sympathetic nerve variants. the purpose of this study is to investigate the anatomical variations of the sympathetic trunk at the levels of t3 and t4 ganglia considered in a topographic approach for sympathetic procedures and to further improve the postoperative outcome. | 2008 | 18375139 |
| neonatal thyroid screening in a mild iodine deficiency endemic area in iran. | evaluated serum thyroid-stimulating hormone (tsh), as an early index for diagnosis of neonatal hypothyroidism, indicates insufficient supply of thyroid hormones. | 2008 | 18376084 |
| effect of combined therapy using balloon-occluded arterial infusion of cisplatin and hemodialysis with concurrent radiation for locally invasive bladder cancer. | we tested the usefulness of combined therapy using balloon-occluded arterial infusion (boai) of cisplatin and hemodialysis, which delivers an extremely high concentration of cisplatin to the site of a tumor without systemic adverse effects, with concurrent radiation in patients with locally advanced bladder cancer. | 2008 | 18376222 |
| effects of ergosan on the expression of cytokine genes in the liver of juvenile rainbow trout (oncorhynchus mykiss) exposed to enteric red mouth vaccine. | the effects of administration of the immunomodulator ergosan, an algal extract containing alginic acid, in juvenile rainbow trout (oncorhynchus mykiss) exposed to aquavac vaccination, were tested. juveniles treated with ergosan, 95 days after the beginning of first solid feeding and control fish fed solely on commercial diet, were vaccinated by immersion in aquavac solution. the time-course of the effects of vaccination on liver immunorelated gene modulation and on the tolerance to stress manipu ... | 2008 | 18378002 |
| synthesis of bisphosphonate derivatives of atp by t4 dna ligase, ubiquitin activating enzyme (e1) and other ligases. | t4 dna ligase and the ubiquitin activating enzyme (e1), catalyze the synthesis of atp beta,gamma-bisphosphonate derivatives. concerning t4 dna ligase: (i) etidronate (pc(oh)(ch(3))p) displaced the amp moiety of the complex e-amp in a concentration dependent manner; (ii) the k(m) values and the rate of synthesis k(cat) (s(-1)), determined for the following compounds were, respectively: etidronate, 0.73+/-0.09 mm and (70+/-10)x10(-3) s(-1); clodronate (pccl(2)p), 0.08+/-0.01 mm and (4.1+/-0.3)x10( ... | 2008 | 18378215 |
| an alternative therapy for graves' disease: clinical effects and mechanisms of an herbal remedy. | graves' disease, the most common cause of hyperthyroidism, is an autoimmune disorder. antithyroid drugs have been selected as the first-line treatment of graves' disease in korea, japan, and european countries. however, antithyroid drugs such as methimazole (mmi) and prophylthiouracil (ptu) have limitations in clinical applications because of their side effects. in this study, we performed a clinical trial and in vitro study to investigate the clinical effects and action mechanism of ahnjeonbaek ... | 2008 | 18379045 |
| urinary retention without tetraparesis as a sequel to spontaneous spinal epidural hematoma. | a 55-year-old man suddenly developed neck pain, tetraplegia and decreased sensation below the neck. he was diagnosed with sseh. surgical removal of the hematoma, and laminoplasty were performed. at 2 months after the onset of the disease, the patient regained the ability to walk. however, at 5 months after the onset of the disease, the patient remained in a state of urinary retention even though his neurological findings were normal, except for mildly brisk reflexes in the lower extremities and ... | 2008 | 18379155 |
| improvement of thermostability of recombinant collagen-like protein by incorporating a foldon sequence. | collagen is a popular biomaterial in many specific biological interactions as well as a structural element. in this work, the recombinant collagen-like proteins were synthesized using escherichia coli expression system. a foldon sequence, gyipeaprdgqayvrkdg ewvllstfl, derived from the native t4 phage fibritin was incorporated at the c-terminal of collagen-like protein molecules to stabilize the triple helix formed in the proteins. the differential scanning calorimetry and thermogravimetric analy ... | 2008 | 18379779 |
| [radiochemotherapeutic options for bladder cancer]. | radical cystectomy remains the standard of care for muscle-invasive bladder cancer, while for high-risk superficial carcinoma an organ-preserving approach, including transurethral resection (tur) and intravesical therapy, is recommended. this review summarizes the radiochemotherpeutic options for high risk t1 or muscle-invasive bladder cancer - as an alternative for/or neoadjuvant therapy before radical surgery. multimodality therapy, including tur, radiation, and chemotherapy, is associated wit ... | 2008 | 18379965 |
| multiple primary primitive neuroectodermal tumours within the spinal epidural space with non-concurrent onset. | a case of multiple primary primitive neuroectodermal tumours (pnets), which occurred at different levels of the spinal epidural space successively over a period of 8 months, is reported. a 24-year-old male, presenting with rapidly progressive paralysis, hyperthesia and a posterior epidural mass extending from t8 to t10 revealed by magnetic resonance imaging (mri), exhibited a good recovery after initial emergency surgery. lower back pain, chest pain and paralysis were subsequently reported. spin ... | 2008 | 18380950 |
| two alternative surgical techniques for enhancing primary implant stability in the posterior maxilla: a clinical study including bone density, insertion torque, and resonance frequency analysis data. | the primary stability of dental implants associated with resistance to micromotion during healing is affected by surgical technique and implant design, which are important especially in the soft bone, where implant failures are more likely. | 2008 | 18384409 |
| sewage bacteriophage photoinactivation by cationic porphyrins: a study of charge effect. | photodynamic therapy has been used to inactivate microorganisms through the use of targeted photosensitizers. recently the inactivation of bacteria in residual waters has been reported, but nothing is known about photoinactivation of environmental bacteriophages, which are often used as indicators of human enteric viruses. in this study we tested the effect of six cationic porphyrin derivatives with two to four charges on the photoinactivation of a sewage bacteriophage. a phage suspension of 5 x ... | 2008 | 18385883 |
| [effect of transcutaneous acupoint electrical stimulation on blood bioactive compounds involving cerebral injury during craniotomy]. | to observe the effect of transcutaneous acupoint electrical stimulation (taes) on plasma et, cgrp and serum il-6, s100beta during craniotomy. | 2008 | 18386641 |
| incidence and risk factors of hypotension and bradycardia after spinal anesthesia for cesarean section. | hypotension or bradycardia after spinal anesthesia for cesarean section remain common and are serious complications. the current study evaluated factors associated to the incidences of hypotension or bradycardia in this context. | 2008 | 18389982 |
| the capsid of the t4 phage superfamily: the evolution, diversity, and structure of some of the most prevalent proteins in the biosphere. | the escherichia coli bacteriophage t4 has served as a classic system in phage biology for more than 60 years. only recently have phylogenetic analyses and genomic comparisons demonstrated the existence of a large, diverse, and widespread superfamily of t4-like phages in the environment. we report here on the t4-like major capsid protein (mcp) sequences that were obtained by targeted polymerase chain reaction (pcr) of marine environmental samples. this analysis was then expanded to include 1,000 ... | 2008 | 18391067 |
| structural analysis of bacteriophage-encoded peptidoglycan hydrolase domain kmv36c: crystallization and preliminary x-ray diffraction. | the c-terminus of gp36 of bacteriophage varphikmv (kmv36c) functions as a particle-associated muramidase, presumably as part of the injection needle of the phikmv genome during infection. crystals of kmv36c were obtained by hanging-drop vapour diffusion and diffracted to a resolution of 1.6 a. the crystals belong to the cubic space group p432, with unit-cell parameters a = b = c = 102.52 a. kmv36c shows 30% sequence identity to t4 lysozyme (pdb code 1l56). | 2008 | 18391422 |
| the effect of occult nodal metastases on survival and regional control in patients with head and neck squamous cell carcinoma. | to determine factors associated with disease-free survival (dfs) and regional control in clinically node-negative head and neck squamous cell cancer (hnscc) patients with occult metastasis. | 2008 | 18391764 |
| the toxicity and outcomes of continuous 5-fluorouracil/cisplatin-based chemotherapy followed by chemoradiation in patients with resected high-risk gastric cancer: results of a single institute. | the majority of patients with gastric cancer relapse after definitive surgery and 5-year survival after surgery is very poor. the intergroup 0116 study showed a modest survival benefit for postoperative bolus 5-fluorouracil-based chemoradiation with a high rate of toxicity. we hypothesised that treatment outcome could be further improved with feasible toxicity using a combination of bolus 5-fluorouracil, continuous 5-fluorouracil, and cisplatin followed by chemoradiation after 3 months of chemot ... | 2008 | 18392298 |
| structure and function of 2:1 dna polymerase.dna complexes. | dna polymerases are required for dna replication and dna repair in all of the living organisms. different dna polymerases are responsible different stages of dna metabolism, and many of them are multifunctional enzymes. it was generally assumed that the different reactions are catalyzed by the same enzyme molecule. in addition to 1:1 dna polymerase.dna complex reported by crystallization studies, 2:1 and higher order dna polymerase.dna complexes have been identified in solution studies by variou ... | 2008 | 18393274 |
| effects of pituitary glycoprotein hormones and thyroid hormones on in-vitro vitellogenin incorporation into organ-cultured oocytes in the japanese eel, anguilla japonica. | the objectives of the present study were to establish a long-term culture system for previtellogenic ovarian fragments of the japanese eel (anguilla japonica) and to identify the effects of salmon pituitary glycoprotein fraction (spg), thyroxine (t4), and 3,5,3'-triiodothyronine (t3) on the uptake of vitellogenin (vtg) by cultured ovarian fragments evidenced by the appearance of yolk globules (ygs) within the oocytes. yolk globules first appeared in the oocytes incubated in media containing only ... | 2008 | 18393571 |
| concomitant chemoradiotherapy with mitomycin c and cisplatin in advanced unresectable carcinoma of the head and neck: phase i-ii clinical study. | to evaluate the toxicity and efficacy of concomitant chemoradiotherapy with mitomycin c and cisplatin in the treatment of advanced unresectable squamous cell carcinoma of the head and neck. | 2008 | 18394816 |
| interference in free thyroxine immunoassay. | we report two patients who presented with non-specific symptoms of tiredness that prompted their clinician to order a thyroid function test. in both cases, free thyroxine (t4) was reported to be high, with a normal thyroid-stimulating hormone (tsh). repeated blood tests from the same laboratory using the same assay method yielded similar results. due to discrepancies between the clinical and laboratory findings, we decided to repeat the blood tests at another laboratory using a different assay m ... | 2008 | 18395170 |
| involvement of the escherichia coli endoribonucleases g and e in the secondary processing of regb-cleaved transcripts of bacteriophage t4. | sequence-specific endoribonuclease regb of bacteriophage t4 cleaves early phage mrnas and facilitates the transition between early and subsequent phases of t4 gene expression. the great majority of regb targets have been identified in the intergenic regions of t4 transcripts, frequently in the shine-dalgarno sequences. here we show that localization of regb targets is not restricted to intergenic regions of mrna. we detected 30 intragenic regb sites in t4 transcripts that are differently suscept ... | 2008 | 18395239 |
| the prognostic significance of tumor vascular invasion and its association with plasma epstein-barr virus dna, tumor volume and metabolic activity in locoregionally advanced nasopharyngeal carcinoma. | parapharyngeal tumor invasion is a known predictor of distant recurrence in stage ii-iii nasopharyngeal carcinoma (npc). this study evaluated the prognostic significance of parapharyngeal and cavernous sinus vascular invasion in stage iii-iv npc, and its association with plasma epstein-barr virus (pebv) dna, disease stage, tumor volume and metabolic activity. eligible patients underwent magnetic resonance imaging (mri), 18f-fluorodeoxyglucose (fdg)-positron-emission tomography (pet) and blood sa ... | 2008 | 18396444 |
| evaluation of the effects of chemical versus biological control on botrytis cinerea agent of gray mould disease of strawberry. | this study investigates on effects of four fungicide and six isolate from trichoderma and gliocladium on botrytis cinerea agent grey mold of strawberry under library and greenhouse condition. the effect of four fungicides i.e. benomyl, dichlofluanid, captan and triadimenol on b. cinerea was studied in the laboratory condition by method mixed poison to culture medium. it was shown that the fungicide including benomyl, triadimenol, dichlofluanid and captan were able to inhibit mycelial growth of b ... | 2007 | 18396812 |
| plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism. | because subclinical thyroid dysfunction may be a risk factor for cardiovascular disease, we evaluated the atherosclerosis tendency in subclinical hypothyroid (sch) patients. | 2008 | 18398274 |
| exogenous subclinical hyperthyroidism impairs endothelial function in nodular goiter patients. | exogenous subclinical hyperthyroidism is associated with cardiovascular and metabolic changes. the aim of this study was to evaluate the effect of levothyroxine (lt4) suppression on endothelial function and insulin sensitivity in euthyroid nodular goiter patients. | 2008 | 18399765 |
| is robotically assisted laparoscopic radical prostatectomy less invasive than retropubic radical prostatectomy? results from a prospective, unrandomized, comparative study. | to evaluate whether robotically assisted laparoscopic prostatectomy (ralp) is less invasive than radical retropubic prostatectomy (rrp), as experimental studies suggest that the acute phase reaction is proportional to surgery-induced tissue damage. | 2008 | 18399830 |
| functional and morphological changes in the adenohypophysis of dogs with induced primary hypothyroidism: loss of tsh hypersecretion, hypersomatotropism, hypoprolactinemia, and pituitary enlargement with transdifferentiation. | from case studies in humans it is known that primary hypothyroidism (ph) may be associated with morphological and functional changes of the pituitary. there is no insight into the time scale of these changes. in this study, seven beagle dogs were followed up for 3 years after the induction of primary hypothyroidism. three of these dogs were followed up for another 1.5 years while receiving l-thyroxine. adenohypophyseal function was investigated at 2-month intervals with the combined intravenous ... | 2008 | 18400449 |
| genetic recombination induced by dna double-strand break in bacteriophage t4: nature of the left/right bias. | the experimental system combining double-strand breaks (dsbs), produced site-specifically by segc endonuclease, with the famous advantages of the bacteriophage t4 rii mutant recombination analysis was used here to elucidate the origin of the recombination bias on two sides of the dsb, especially pronounced in gene 39 (topoisomerase ii) and gene 59 (41-helicase loader) mutants. three sources were found to contribute to the bias: (1) the segc endonuclease may remain bound to the end of the broken ... | 2008 | 18400566 |
| [dynamic observation of hormonal characteristics in the newborn babies with periventricular leukomalacia during their first week of lives]. | the problem of peculiarity of hormonal adaptation in newborn babies with periventricular leucomalacia--a condition that causes lifelong disability, in spite of its scientific and practical value is not adequately explored. the aim of the research was to investigate hormonal characteristics in the newborn babies with periventricular leucomalacia and to determine clinical and laboratory criteria for early prognosis of periventricular leucomalacia. dynamic observation was conducted on 48 newborn ba ... | 2008 | 18401046 |
| acute keratoconus induced by hypothyroxinemia during pregnancy. | keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population. the etiology of keratoconus is multifactorial, although not completely understood. several clinical observations suggest that thyroid gland dysfunction is associated with keratoconus pathophysiology. pregnancy represents a major alteration in the maternal endocrinologic status characterized by modified function of the thyroid gland. we report on a 33-yr-old pregnan ... | 2008 | 18401210 |
| further evidence for the involvement of anatomical parameters of the cardiopulmonary system in the development of ascites syndrome in broiler chickens. | eggs from a broiler line were incubated at two different altitudes and hatched. relative heart and lung weights, volumes of the heart, lung and thoracic cavity, incidence of right ventricular hypertrophy and ascites, and related physiological parameters were followed in the day-old chickens hatched from the above eggs. lung and heart weights as a percentage of body weight, lung and heart volumes relative to the volume of the thoracic cavity after removing the heart and lungs were higher in chick ... | 2008 | 18401957 |
| effects of olprinone on neuromuscular blockade caused by vecuronium. | we studied the effect of olprinone on neuromuscular blockade caused by vecuronium. thirty women undergoing nitrous oxide-oxygen-isoflurane anesthesia were randomly divided into olprinone (n=15) or control group (n=15). in the olprinone group, the patients received an intravenous initial loading dose of olprinone at a rate of 2 microg/kg/minute for 5 minutes, followed by a continuous infusion of olprinone at 0.3 microg/kg/minute. in the control group, the patients received normal saline. thirty m ... | 2007 | 18402286 |
| structure, cytotoxicity, and dna-cleavage properties of the complex [cu(ii)(pbt)br2]. | the reactions of the ligand 2-(2-pyridyl)benzthiazole (pbt) with cubr 2 and zncl 2 in acetonitrile produce the complexes [cu(pbt)br 2] ( 1) and [zn(pbt)cl 2] ( 3), respectively. when complex 1 is dissolved in dmf, complex 2 is obtained as light-green crystals. the reaction of pbt with cubr 2 in dmf also yields the complex [cu(pbt)br 2(dmf)] ( 2) (dmf = dimethylformamide). complexes 1- 3 were characterized by x-ray crystallography. complexes 1 and 3 have distorted tetrahedral coordination environ ... | 2008 | 18402438 |
| [transurethral resection in prostate cancer, a radical procedure. experience with 1017 cases]. | from the beginning of tur in 1931 the reseccionists thought of resecting prostate cancer. execution however failed for deficient instruments and techniques. the first transurethral resection for prostate cancer: turpc--was performed at our institution in 1957 by hans j. reuter. low pressure irrigation enabled safe transurethral resection of the prostate including the capsule. thus we started in 1985 a prospective study to verify turpc as a radical procedure. | 2008 | 18405024 |
| the addition of robotic surgery to an established laparoscopic radical prostatectomy program: effect on positive surgical margins. | the addition of robotic assistance with the da vinci surgical system for performing laparoscopic radical prostatectomy has been reported to improve surgical outcomes. in order to evaluate the benefit of robotic assistance to improve cancer control in a center with an established laparoscopic radical prostatectomy program, we evaluated the incidence of positive surgical margins in both transperitoneal laparoscopic (lrp) and robotically assisted laparoscopic radical prostatectomy (ralp). | 2008 | 18405448 |
| a phase i trial of definitive chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil (dcf-r) for advanced esophageal carcinoma: kitasato digestive disease & oncology group trial (kdog 0501). | a dose-escalation study of docetaxel combined with cisplatin, 5-fluorouracil, and concurrent radiotherapy (dcf-r) was performed to determine the optimal dose in patients with advanced esophageal carcinoma. | 2008 | 18405987 |
| production of a recombinant industrial protein using barley cell cultures. | the use of recombinant dna-based protein production using genetically modified plants could provide a reproducible, consistent quality, safe, animal-component free, origin-traceable, and cost-effective source for industrial proteins required in large amounts (1000s of metric tons) and at low cost (below us$100/kg). the aim of this work was to demonstrate the feasibility of using barley suspension cell culture to support timely testing of the genetic constructs and early product characterization ... | 2008 | 18406168 |
| isolation of dunaliella spp. from a hypersaline lake and their ability to accumulate glycerol. | the purpose of the present work was to study the potential biotechnological use of dunaliella species isolated from a hypersaline lake in turkey. dunaliella spp. grown in johnson's medium were isolated and their glycerol production was studied in a batch system in order to determine the optimal conditions required for the highest glycerol accumulation. in the experiments performed with four newly isolated dunaliella spp., the maximum glycerol accumulation was obtained at 20% nacl concentration, ... | 2008 | 18406610 |
| chemoradiation therapy for potentially resectable gastric cancer: clinical outcomes among patients who do not undergo planned surgery. | we retrospectively analyzed treatment outcomes among resectable gastric cancer patients treated preoperatively with chemoradiation therapy (crt) but rendered ineligible for planned surgery because of clinical deterioration or development of overt metastatic disease. | 2008 | 18406886 |
| changes in thyroid function in nonthyroid illness. | nonthyroid illness can cause changes in thyroid function that have been described as low triiodothyronine (t(3)) and low thyroxine (t(4)) states. reduced peripheral conversion of t4 to t(3) explains the low serum t(3) concentration. the explanation for the low serum t(4) level is multifactorial; whether free-thyroxine (ft(4)) level is normal or reduced remains controversial. cytokines such as tumor necrosis factor alpha, which are produced by the immune system during severe illness, may inhibit ... | 1992 | 18407071 |
| comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury. | in this study, we aimed to investigate the biochemical and histopathological protective effects of octreotide and melatonin in an experimental model of spinal cord injury. fifty- six male albino wistar rats were divided into four groups. rats in the g1 group (n=7; control group) did not undergo any treatment except for anesthesia prior to being killed. rats in the g2 group (n=7) underwent laminectomy and aneurysmal clip application at the t4-5 level. g3 group rats (n=14) were either treated with ... | 2008 | 18407497 |
| [a case of advanced esophageal cancer with large liver metastasis successfully treated with fap therapy]. | a 70-year-old man with dysphagia was diagnosed as advanced esophageal cancer by a primary doctor, and he was admitted to our hospital for treatment in february, 2004. the pretreatment diagnosis was basaloid squamous carcinoma, mt area, t4 (aorta) , n2 (no. 107) , m1 (liver), stage ivb performed systemic chemotherapy by fap (5-fluorouracil ( 5-fu)+doxorubicin (dxr)+cisplatin (cddp) ) from march, 2004. after 4 courses, the local tumor almost entirely disappeared, and the liver metastasis was obvio ... | 2008 | 18408432 |
| human replication protein a melts a dna triple helix structure in a potent and specific manner. | alternate dna structures other than double-stranded b-form dna can potentially impede cellular processes such as transcription and replication. the dna triplex helix and g4 tetraplex structures that form by hoogsteen hydrogen bonding are two examples of alternate dna structures that can be a source of genomic instability. in this study, we have examined the ability of human replication protein a (rpa), a single-stranded dna binding protein that is implicated in all facets of dna metabolism, to d ... | 2008 | 18410127 |
| expression of runx3 in salivary adenoid cystic carcinoma: implications for tumor progression and prognosis. | runt-related transcription factor-3 (runx3), being a tumor suppressor gene in gastric cancer, plays an important role in inhibiting cellular growth by participating in the transforming growth factor-beta-dependent apoptosis. the aim of this study was to determine the expression of runx3 in normal salivary glands and adenoid cystic carcinomas (accs), comparing the results with clinicopathological factors and patient survival. the quantitative reverse transcription-polymerase chain reaction (rt-pc ... | 2008 | 18410404 |
| evaluation of dynamic sentinel lymph node biopsy in patients with squamous cell carcinoma of the penis and palpable inguinal nodes. | to evaluate dynamic sentinel lymph node biopsy (dslnb) in patients with squamous cell carcinoma (scc) of the penis and palpable inguinal lymph nodes, using inguinal lymph node dissection (ilnd) as the reference standard to assess the reliability of dslnb, as using radioscintigraphy and colloidal blue-dye injection to locate the sln was reported to be a useful technique to avoid ilnd in men with scc of the penis and clinically impalpable nodes. | 2008 | 18410439 |
| diagnosis and management of amiodarone-induced thyrotoxicosis: similarities and differences between north american and european thyroidologists. | to investigate how north american thyroidologists assess and treat amiodarone-induced thyrotoxicosis (ait) and to compare the results with those of the same questionnaire-based survey previously carried out among european thyroidologists. | 2008 | 18410546 |
| polymorphisms in the brain-specific thyroid hormone transporter oatp1c1 are associated with fatigue and depression in hypothyroid patients. | some hypothyroid patients continue to have significant impairments in psychological well-being, despite adequate treatment with levothyroxine (lt4). t4 transport across the blood-brain barrier is one of the crucial processes for thyroid hormone action in the brain. oatp1c1, a thyroid hormone transporter expressed at the blood-brain barrier, is considered to play a key role in delivering serum t4 to the brain. | 2008 | 18410547 |
| arterial chemoradiotherapy for locally advanced tongue cancer: analysis of retrospective study of therapeutic results in 88 patients. | to retrospectively investigate the therapeutic results of arterial injection therapy by way of the superficial temporal artery for 88 cases of stage iii and iv (m0) tongue cancer and to clarify the factors that affected the therapeutic results. | 2008 | 18411003 |
| parametrization, molecular dynamics simulation, and calculation of electron spin resonance spectra of a nitroxide spin label on a polyalanine alpha-helix. | the nitroxide spin label 1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl-methanethiosulfonate (mtssl), commonly used in site-directed spin labeling of proteins, is studied with molecular dynamics (md) simulations. after developing force field parameters for the nitroxide moiety and the spin label linker, we simulate mtssl attached to a polyalanine alpha-helix in explicit solvent to elucidate the factors affecting its conformational dynamics. electron spin resonance spectra at 9 and 250 ghz are simu ... | 2008 | 18412413 |
| hepatocellular integrity in patients requiring parenteral nutrition: comparison of structured mct/lct vs. a standard mct/lct emulsion and a lct emulsion. | the aetiology of parenteral nutrition-associated hepatic injury remains unresolved. the aim of the study was to evaluate the effects of structured triglycerides in parenteral nutrition compared either to a physical medium-chain triglycerides (mct)/long-chain triglcerides (lct) mixture or to a lct emulsion on hepatic integrity. | 2008 | 18413006 |
| ten-year follow-up of radiation therapy oncology group protocol 92-02: a phase iii trial of the duration of elective androgen deprivation in locally advanced prostate cancer. | to determine whether adding 2 years of androgen-deprivation therapy (adt) improved outcome for patients electively treated with adt before and during radiation therapy (rt). | 2008 | 18413638 |
| incorporating the amino acid properties to predict the significance of missense mutations. | determining if missense mutations are deleterious is critical for the analysis of genes implicated in disease. however, the mutational effects of many missense mutations in databases like the breast cancer information core are unclassified. several approaches have emerged recently to determine such mutational effects but none have utilized amino acid property indices. we modified a previously described phylogenetic approach by first classifying benign substitutions based on the assumption that m ... | 2008 | 18415037 |
| central hypothyroidism. | central hypothyroidism (ch) is a rare cause of hypothyroidism due to an insufficient stimulation of an otherwise normal thyroid gland and it is caused by either pituitary (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism) defects. the diagnosis of ch is usually suggested by the finding of lowered thyroid hormone concentrations, associated with inappropriately low/ normal tsh levels. restoration and maintenance of euthyroidism represent the therapeutic goals in all forms of ch. ... | 2008 | 18415684 |
| effects of zero-balanced ultrafiltration on procalcitonin and respiratory function after cardiopulmonary bypass. | the abnormal conditions to which blood is subjected during cardiopulmonary bypass (cpb) trigger an activation of the inflammatory response and cause pulmonary dysfunction. it has been suggested that high-volume, zero-balanced ultrafiltration (zbuf) facilitates clearance of inflammatory mediators and improves post-operative pulmonary function. procalcitonin, a newly discovered inflammatory mediator, has been found to be increased after cpb and has been proven to be an appropriate parameter for pr ... | 2007 | 18416220 |
| a phase ii multicentre study of irinotecan (cpt 11) in combination with cisplatin (cddp) in metastatic or locally advanced penile carcinoma (eortc protocol 30992). | the aim of this study is to determine efficacy and feasibility of the combination regimen irinotecan and cisplatin in patients with cisplatin advanced penile cancer. | 2008 | 18417462 |
| tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. | tumor volume has been demonstrated to play a prognostic role in many head and neck cancers. the purpose of this study was to conduct an institutional review analyzing the correlation between tumor volume and locoregional control of oropharyngeal squamous cell cancer treated with primary radiotherapy. | 2008 | 18418275 |
| prognostic impact of primary tumor volume in patients with nasopharyngeal carcinoma treated by definitive radiation therapy. | tumor burden has been confirmed as one of the important indicators in disease control after treatment for various types of malignancies. this report aims to document the value of the primary tumor volume of nasopharyngeal carcinoma [gross tumor volume of the primary site (gtv-p)] in predicting the treatment outcome after high-dose definitive radiation therapy. | 2008 | 18418278 |
| oxidative stress regulates type 3 deiodinase and type 2 deiodinase in cultured rat astrocytes. | type 2 deiodinase (d2) and type 3 deiodinase (d3) locally achieve the determination of the concentration of t3, which binds to the thyroid hormone receptor with high affinity. d2 converts t4 into t3, and d3 degrades t4 and t3. neurons take up t3 released by astrocytes, the main cerebral site for the d2 expression. because oxidative stress is believed to be involved in several neurological disorders, we explored the effects of oxidative stress on d3 and d2 in primary culture of rat astrocytes. h2 ... | 2008 | 18420745 |
| cardiac output measurement in patients undergoing liver transplantation: pulmonary artery catheter versus uncalibrated arterial pressure waveform analysis. | cardiac output (co) and invasive hemodynamic measurements are useful during liver transplantation. the pulmonary artery catheter (pac) is commonly used for these patients, despite the potential complications. recently, a less invasive device (vigileo/flotrac) became available, which estimates co using arterial pressure waveform analysis without external calibration. in this study, we compared co obtained with a pac using automatic thermodilution, instantaneous co stat-mode (ico(sm)), and co obta ... | 2008 | 18420863 |
| the effect of quicklime (cao) on litter condition and broiler performance. | high levels of phosphorus and pathogens in runoff are 2 major concerns following manure applications to fields. phosphorus losses from fields following manure applications have been linked to the solubility of phosphorus in manure; therefore, by decreasing manure phosphorus solubility, a decrease in phosphorus loss in runoff should be apparent. the objective of this research was to develop a process using quicklime that would result in reduced phosphorus solubility and bacteria counts in broiler ... | 2008 | 18420971 |
| useful combination of intra-arterial chemotherapy and radiation therapy for lateral oropharyngeal wall cancer. | a concomitant treatment of intra-arterial chemotherapy and radiation therapy is a promising therapeutic option for oropharyngeal cancers. | 2008 | 18421615 |
| [male breast cancer: a review of 52 cases collected at the institute bergonié (bordeaux, france) from 1980 to 2004]. | to analyze the characteristics and to establish prognosis factors for 52 men suffering from breast cancer from 1980 to 2004. | 2008 | 18424216 |
| [endoscopic ultrasound in the preoperative staging of gastric cancer: correlation with the surgical and/or pathological findings]. | gastric adenocarcinoma is the major cause of death by cancer in brazil. for the planning of the treatment and evaluation of the prognosis, the preoperative staging according to the tnm classification is very important. | 2008 | 18425224 |
| involvement of epha2 in head and neck squamous cell carcinoma: mrna expression, loss of heterozygosity and immunohistochemical studies. | epha2 is a 130-kda transmembrane protein primarily found in adult human epithelial cells and is a member of one of the largest receptor tyrosine kinases. it is located on 1p36.1, a genetic hot spot in cancer. epha2 overexpression has been observed in aggressive solid tumors and its potential role in tumorigenesis, which includes cell growth, survival, migration and angiogenesis have been reported. however, the role of epha2 remains unknown in head and neck cancer. in this study, we investigated ... | 2008 | 18425361 |
| the effect of peripheral administration of zinc on food intake in rats fed zn-adequate or zn-deficient diets. | zinc deficiency induces a striking reduction of food intake in animals. to elucidate the mechanisms for this effect, two studies were connectedly conducted to determine the effects of peripheral administration of zinc on food intake in rats fed the zinc-adequate or zinc-deficient diets for a 3-week period. in study 1, two groups of male sprague-dawley rats were provided diets made either adequate (za; 38.89 mg/kg) or deficient (zd; 3.30 mg/kg) in zinc. in study 2, after feeding for 3 weeks, both ... | 2008 | 18425433 |
| overexpression of aib1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage. | aib1, a candidate oncogene in breast cancer, is commonly amplified and overexpressed in several types of human cancers. in this study, expression and amplification of aib1 in nasopharyngeal carcinoma (npc) were studied by immunohistochemical analysis and fluorescence in situ hybridization using tissue microarrays, including 80 specimens of npc and 20 specimens of nonneoplastic nasopharyngeal mucosa. in this npc cohort, overexpression and amplification of aib1 was detected in 36 (51%) of 71 and 3 ... | 2008 | 18426732 |
| hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with gata4 and kruppel-like transcription factor 9. | type 1 iodothyronine deiodinase (dio1), a selenoenzyme catalyzing the bioactivation of thyroid hormone, is highly expressed in the liver. dio1 mrna and enzyme activity levels are markedly reduced in the livers of hepatocyte nuclear factor 4alpha (hnf4alpha)-null mice, thus accounting for its liver-specific expression. consistent with this deficiency, serum t4 and rt3 concentrations are elevated in these mice compared with those in hnf4alpha-floxed control littermates; however, serum t3 levels ar ... | 2008 | 18426912 |
| surgical results and related factors for ossification of posterior longitudinal ligament of the thoracic spine: a multi-institutional retrospective study. | retrospective multi-institutional study | 2008 | 18427326 |
| [comparative analysis of long-term results of combined and surgical treatment at the patients with signet ring cell carcinoma of stomach]. | overall 194 patients with signet ring cell carcinoma of stomach were treated, 124 (64%) of them underwent combined treatment (preoperative radiotherapy with subsequent operation), 70 (36%) - only surgical treatment. there were no differences in survival rate between two groups at early (pt1) cancer. the combined method has advantages over isolated surgical at t2 tumors (both with and without regional lymphatic metastases) and at t3 tumors without regional lymphatic metastases (p=0.03). at t3n1-2 ... | 2008 | 18427465 |
| common buffers, media, and stock solutions. | this appendix describes the preparation of selected bacterial media and of buffers and reagents used in the manipulation of nucleic acids and proteins. recipes for cell culture media and reagents are located elsewhere in the manual. recipes: acids, concentrated stock solutions; ammonium acetate, 10 m; ammonium hydroxide, concentrated stock solution; atp, 100 mm; bcip, 5% (w/v); bsa (bovine serum albumin), 10% (100 mg/ml); denhardt solution, 100x; dntps: datp, dttp, dctp, and dgtp; dtt, 1 m; edta ... | 2001 | 18428217 |
| enzymatic labeling of dna. | this appendix describes the preparation of uniformly labeled radioactive probes by nick translation and random oligonucleotide-primed synthesis, as well as the end-labeling of oligonucleotides by t4 polynucleotide kinase. accompanying these protocols are methods for removing unincorporated dntp precursors with spin columns and for measuring the specific activity of a probe by acid precipitation. | 2001 | 18428222 |
| construction of small-insert libraries from genomic dna. | construction of small-insert genomic libraries involves ligation of a size-selected insert to vector dna. in this unit, vector dna is prepared by digestion with a restriction endonuclease followed by phosphatase treatment to dephosphorylate the vector ends. insert dna is prepared by complete digestion of dna with a compatible 4-base-cutting restriction endonuclease (e.g., alui, haeiii, rsai, or sau3a), as such frequently cutting endonucleases give the highest fragment number in the desired range ... | 2001 | 18428265 |
| rna analysis by nuclease protection. | nuclease protection assays (s1 nuclease protection and rnase protection) are extremely sensitive procedures for detection and quantitation of mrna species in complex mixtures of total cellular rna. these assays are well suited for mapping positions of external and internal junctions in rna, such as transcription initiation and termination sites and intron/exon boundaries, and to discriminate between closely related targets by using probes designed to span the regions where the related genes diff ... | 2003 | 18428580 |
| exonuclease activity of proofreading dna polymerases is at the origin of artifacts in molecular profiling studies. | ce fingerprint methods are commonly used in microbial ecology. we have previously noticed that the position and number of peaks in ce-sscp (single-strand conformation polymorphism) profiles depend on the dna polymerase used in pcr [1]. here, we studied the fragments produced by taq polymerase as well as four commercially available proofreading polymerases, using the v3 region of the escherichia coli rss gene as a marker. pcr products rendered multiple peaks in denaturing ce; taq polymerase was o ... | 2008 | 18429330 |
| effects of t4 replacement therapy on glucose metabolism in subjects with subclinical (sh) and overt hypothyroidism (oh). | to evaluate beta-cell function and insulin sensitivity in subjects with overt (oh) and subclinical hypothyroidism (sh) before and after t4 replacement therapy. | 2008 | 18429948 |
| impact of hemoglobin level on survival in definitive chemoradiotherapy for t4/m1 lymph node esophageal cancer. | we retrospectively investigated the impact of the pre-chemoradiotherapy hemoglobin level (pre-crt hb level) for t4 and/or m1 lymph node (lym) squamous cell carcinoma of the esophagus. chemotherapy consisted of protracted infusion with 5-fluorouracil (5-fu) at 400 mg/m(2)/day on days 1-5 and 8-12, combined with cisplatin at 40 mg/m(2)/day on days 1 and 8, repeated twice at a 5-week interval. concurrent radiation therapy was started on day 1 and delivered at 2 gy/day for five days a week for a tot ... | 2008 | 18430098 |
| the effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male fischer 344 rats. | acrylamide (aa) is an important industrial chemical that is neurotoxic in rodents and humans and carcinogenic in rodents. the observation of cancer in endocrine-responsive tissues in fischer 344 rats has prompted hypotheses of hormonal dysregulation, as opposed to dna damage, as the mechanism for tumor induction by aa. the current investigation examines possible evidence for disruption of the hypothalamic-pituitary-thyroid axis from 14 days of repeated exposure of male fischer 344 rats to doses ... | 2008 | 18430446 |
| does endoesophageal ultrasound-guided fine-needle aspiration replace mediastinoscopy in mediastinal staging of thoracic malignancies? | to determine the impact of endoesophageal ultrasound-guided fine-needle aspiration (eus-fna) on management of thoracic malignancies. | 2008 | 18430581 |
| synthesis of hiv-1 psi-site rna sequences with site specific incorporation of the fluorescent base analog 2-aminopurine. | fluorescent nucleotide base analogs can serve as sensitive probes of the local structure and chemical environment of the base within a nucleic acid sequence. a significant strength of these base analogs is their similarity in molecular constitution and chemical properties to natural bases. while chemical synthesis has afforded the ability to generate oligonucleotides in good yield with sequence-specific incorporation of fluorescent base analogs, this method is limited in practice to the synthesi ... | 2007 | 18431441 |
| beneficial effect of modified egg on serum t3, t4 and dyslipidaemia following dietary zn-supplementation in wistar rat. | a fall in serum t3 and t4 along with increase in serum cholesterol, triglycerides, ldl-c and vldl-c and decrease in hdl-c was observed in albino wistar rats when fed on semi-synthetic diet containing either 40 or 80mg zn/kg diet. zn concentrations were observed to increase with decreased concentration of cu and mg in their tissues. on including modified egg (indian patent application no. 2264\del\2005) in the zn supplement diet, the levels of t3 and t4, lipid profile in serum and mineral status ... | 2008 | 18432056 |
| t cell depletion by cytotoxic elimination. | this unit describes the complete removal of t cells from lymphocyte preparations based on the presence of the glycoprotein thy-1 on the cell surface of t lymphocytes. as in unit 3.3, cytotoxic elimination is employed; however, thy-1-specific antibodies are used rather than mhc class ii-specific antibodies so that t cells are eliminated rather than b cells and accessory cells. murine t cells can be further fractionated into subpopulations based on their expression of cell differentiation markers ... | 2001 | 18432789 |
| [perineal wound complications following preoperative radiotherapy for rectal cancer]. | every year, approximately 1200 new cases of rectal cancer are registered in denmark. preoperative radiation therapy alone or in combination with chemotherapy (chemo-radiation) is a gold standard in the treatment of patients with t3 and t4 tumours. although it carries a good response rate, preoperative radiation is associated with significant morbidity including wound infection and delayed healing. the aim of this study is to clarify the effects of preoperative radiotherapy on wound healing in pa ... | 2008 | 18433575 |
| intracranial hypotension following scoliosis surgery: dural penetration of a thoracic pedicle screw. | the authors report on a 14 years old female with intracranial hypotension who had a history of spinal instrumentation surgery for scoliosis 3 months prior to her admission. she had been diagnosed with migraine in a neurology clinic and was under medical therapy when presented. during the investigation process, a right thoracic pedicle screw, which was penetrating and transversing the dura mater at the t3-t4 level was identified. the diagnosis and management of such a case is discussed. knowledge ... | 2008 | 18437432 |
| cationic agents for dna compaction. | fluorescence microscopy was used to investigate the conformational changes of individual t4 dna molecules induced by different compacting agents, namely the cationic surfactants, cetyltrimethylammonium bromide (ctab) and chloride (ctac), iron(iii), lysozyme, and protamine sulfate. a protocol for establishing size estimates is suggested to obtain reproducible results. observations show that in the presence of lysozyme and protamine sulfate, dna molecules exhibit a conformational change from an el ... | 2008 | 18440012 |
| environment and endocrinology: the case of thyroidology. | evidence is accumulating for interference of selected endocrine disrupting chemicals (edc) with the thyroid axis. edc disturb thyroid hormone (th) homeostasis leading to developmental defects, hypothyroidism and altered thyroid growth patterns. a rising incidence of papillary thyroid carcinoma (ptc) in several western countries cannot be definitely accounted for by improved diagnosis or management of thyroid cancer or improved iodine supply. in recent studies, we and others detected, within the ... | 2008 | 18440490 |
| anxiety and depression in patients with prostate cancer and other urogenital cancer: a longitudinal study. | the aim of this study was to assess the degree and the course of psychological distress (anxiety and depression) in cancer patients and to detect sociodemographic determinants of the scores. | 2009 | 18440838 |
| identification of brominated and chlorinated phenols as potential thyroid-disrupting compounds in indoor dusts. | our previous study demonstrated that compounds in indoor dusts strongly inhibit thyroxine (t4) binding to the human thyroid hormone transport protein transthyretin (ttr) in vitro. exposure assessment indicated that house dust is an important medium of exposure of children to ttr-binding compounds when binding potency and dust ingestion rates are high. here, we used chemical fractionation with in vitro competitive human ttr-binding assay and gc-ms to analyze the ttr-binding compounds in a sulfuri ... | 2008 | 18441837 |
| [prokaryotic expression of trichinella spiralis gene ts21 and identification of the recombinant protein]. | to express the antigen gene ts21 of trichinella spiralis, purify the recombinant protein and test its antigenicity. | 2007 | 18441887 |
| spatial and temporal distribution patterns of na-k-2cl cotransporter in adult and developing mouse retinas. | the na-k-2cl cotransporter (nkcc) is a cl(-) uptake transporter that is responsible for maintaining a cl(-) equilibrium potential positive to the resting potential in neurons. if nkcc is active, gaba and glycine can depolarize neurons. in view of the abundance of gabaergic and glycinergic synapses in retina, we undertook a series of studies using immunocytochemical techniques to determine the distribution of nkcc in retinas of both developing and adult mice. we found nkcc antibody (t4) labeling ... | 2008 | 18442435 |
| molecular characterization, gene expression and transcriptional regulation of cytosolic hsp90 genes in the flatfish senegalese sole (solea senegalensis kaup). | hsp90 proteins are chaperones that play a pivotal role in controlling multiple regulatory pathways such as stress defense, hormone signalling, cell cycle control, cell proliferation and differentiation, and apoptosis. in this study, two cdnas encoding for cytosolic hsp90, referred to as hsp90aa and hsp90ab, have been sequenced. main features and sequence identities with other fish and mammals are described. phylogenetic analysis grouped both genes into two separate clusters with their fish and m ... | 2008 | 18442885 |
| effects of a multifaceted psychiatric intervention targeted for the complex medically ill: a randomized controlled trial. | this study evaluated a multifaceted psychiatric intervention targeted at the complex medically ill identified by means of the intermed, an instrument to assess case complexity. | 2008 | 18443391 |
| novobiocin inhibits the self-splicing of the primary transcripts of t4 phage thymidylate synthase gene. | effects of the antibiotic novobiocin on the self-splicing of primary transcripts of the phage t4 thymidylate synthase gene (td) have been investigated. novobiocin at 10 mm concentration inhibited the splicing by about 5% but at 40 mm concentration the splicing rate was inhibited by about 50%. the novobiocin inhibition of the self-splicing reaction was not reversed even at a high concentration (200 microm) of guanosine. however, increasing the mg(2+) ion concentrations up to 20 mm almost fully re ... | 2008 | 18443742 |
| [idiopathic spinal epidural hematoma in patients with sudden paraplegia: a case report]. | spontaneous spinal epidural hematoma (seh) represents 0.3-0.9% of spinal epidural space-occupying lesions, and most surgeons advocate aggressive and early surgical intervention. in this paper we describe a patient with seh with sudden paraplegia. | 2008 | 18446696 |
| linear growth, growth-hormone secretion and igf-i generation in children with neglected hypothyroidism before and after thyroxine replacement. | we studied growth hormone (gh) stimulation and insulin-like growth factor -i (igf-i) generation tests in 15 children with neglected congenital hypothyroidism (ch) (age = 6.4 +/- 4.2 years) and measured their growth parameters for >1 years after starting thyroxine (t4) replacement. one year after treatment, height sds (htsds) increased from -4.3 +/- 2.5 to -2.7 +/- 2.3. peak gh response to clonidine increased from 3.2 +/- 1.2 ng ml(-1) to 7.62 +/- 1.38 ng ml(-1) after treatments. basal and peak i ... | 2008 | 18450819 |
| lack of a co-promotion effect of 60 hz rotating magnetic fields on n-ethyl-n-nitrosourea induced neurogenic tumors in f344 rats. | the present study was conducted to investigate the possible effect of 60 hz magnetic fields as promoters of brain tumors initiated transplacentally by ethylnitrosourea (enu) in f344 rats. one hundred twenty mated animals were divided into six different groups and exposed in utero on day 18 of gestation to a single intravenous dose of either saline (vehicle control, group i), or enu 10 mg/kg (groups ii-vi). in the present study, a total of 480 offspring was used. the offspring in group ii were gi ... | 2008 | 18452166 |
| the effect of gene therapy using ctla4ig/silica-nanoparticles on canine experimental autoimmune thyroiditis. | the present study aimed to determine the effect of canine ctla4ig on canine autoimmune thyroiditis. in a previous study, we established a canine model of autoimmune thyroiditis by immunizing normal dogs with bovine thyroglobulin. an in vitro study using recombinant ctla4ig revealed that this protein can inhibit the expression of th1-type cytokines and the pro-inflammatory cytokines tested. | 2008 | 18452240 |
| prognostic factors of renal cell carcinoma with extension into inferior vena cava. | to evaluate the prognosis of our series of patients with renal cell carcinoma (rcc) and tumor thrombus involving inferior vena cava (ivc) treated with nephrectomy and thrombectomy. | 2008 | 18452454 |