Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| efficacy of bronchodilators in the treatment of bronchiolitis. | bronchiolitis is a common respiratory infection affecting young children. much controversy revolves around the efficacy of bronchodilators in the treatment of bronchiolitis. this study was conducted to address this issue. | 1997 | 9364884 |
| acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden. | to evaluate the disease burden of upper respiratory infections in elderly people living at home. | 1997 | 9366736 |
| dairy calf pneumonia. the disease and its impact. | the author discusses the syndrome of respiratory, disease in dairy calves, reviewing the disease and the causative agents. attention is given to the epidemiology of the disease with discussion of morbidity, mortality, proportionate mortality and risk factors associated with dairy calf pneumonia. the economic impact of dairy calf pneumonia is discussed in detail and management options for calf rearing are suggested. | 1997 | 9368984 |
| bovine respiratory syncytial virus. | since the first report of brsv in the 1970s, the understanding of this agent and its respective disease has increased dramatically. current evidence supports a major role for this virus in bovine respiratory disease. advances in diagnostics have increased the ability to demonstrate this virus in field outbreaks of respiratory disease. the clinical signs and pathologic features have been well described, and vaccines are available to aid in prevention and control. still, many questions remain to b ... | 1997 | 9368988 |
| recombinant respiratory syncytial virus from which the entire sh gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. | the small hydrophobic protein sh of human respiratory syncytial virus (rsv) is a short transmembrane surface protein of unknown function. a full-length cdna of rsv strain a2 (subgroup a) antigenomic rna was modified such that the entire sh gene, including the transcription signals and the complete mrna-encoding sequence, was deleted and replaced by a synthetic intergenic region. this reduced the length of the antigenome by 398 nucleotides and ablated expression of 1 of the 10 rsv mrnas. recombin ... | 1997 | 9371553 |
| cloning, expression and functional activities of a single chain antibody fragment directed to fusion protein of respiratory syncytial virus. | hnk20 is a murine iga which is currently being investigated in clinical trials against respiratory syncytial virus (rsv) infections in infants and young children. | 1996 | 9373314 |
| human monoclonal fab fragments specific for viral antigens from combinatorial iga libraries. | iga constitutes the first line of immune defense, interacting with a variety of environmental antigens. following infection with respiratory syncytial virus (rsv) individuals frequently exhibit elevated serum iga titers specific for the virus. previously combinatorial igg libraries have successfully been used to clone such human antibody responses. | 1995 | 9373330 |
| respiratory syncytial virus immune globulin treatment of rsv lower respiratory tract infection in previously healthy children. | to evaluate the efficacy of high titer respiratory syncytial virus (rsv) immune globulin (rsvig) in the treatment of previously healthy children hospitalized with proven rsv lower tract infection (lri). | 1997 | 9374560 |
| nosocomial respiratory syncytial virus infection in canadian pediatric hospitals: a pediatric investigators collaborative network on infections in canada study. | to determine nosocomial transmission of respiratory syncytial virus (rsv) in canadian pediatric hospitals, outcomes associated with nosocomial disease, and infection control practices. | 1997 | 9374561 |
| rehospitalization with respiratory syncytial virus after neonatal intensive care unit discharge: a 3-year follow-up. | this study sought to determine 1) the incidence of rehospitalization with respiratory syncytial virus (rsv) infection within a 3-year follow-up among infants discharged from the neonatal intensive care unit (nicu), and 2) to examine associations between age at readmission and medical and sociodemographic characteristics among infants rehospitalized with rsv. | 1997 | 9382909 |
| long term follow-up of children hospitalized with respiratory syncytial virus lower respiratory tract infection and randomly treated with ribavirin or placebo. | to determine the long term effects of ribavirin therapy in children hospitalized for respiratory syncytial virus (rsv) lower respiratory tract infection. | 1997 | 9384333 |
| respiratory syncytial virus (rsv) sh and g proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated rsv subgroup b mutant. | a live, cold-passaged (cp) candidate vaccine virus, designated respiratory syncytial virus (rsv) b1 cp-52/2b5 (cp-52), replicated efficiently in vero cells, but was found to be overattenuated for rsv-seronegative infants and children. sequence analysis of reverse-transcription-pcr-amplified fragments of this mutant revealed a large deletion spanning most of the coding sequences for the small hydrophobic (sh) and attachment (g) proteins. northern blot analysis of cp-52 detected multiple unique re ... | 1997 | 9391135 |
| the need for inotropic support in a subgroup of infants with severe life-threatening respiratory syncytial viral infection. | we experienced an unusual complication of life-threatening respiratory syncytial viral disease cardiovascular compromise. life-threatening respiratory syncytial virus (rsv) infection has predominancy involved with ventilatory support for respiratory distress and/or failure. we performed a retrospective chart review of 20 consecutive infants admitted to the pediatric intensive care unit (picu) for impending respiratory failure. | 1997 | 9394100 |
| structural properties of chimeric peptides containing a t-cell epitope linked to a fusion peptide and their importance for in vivo induction of cytotoxic t-cell responses. | we have previously shown that when administered to mice without adjuvant, a chimeric peptide consisting of the fusion peptide f from measles virus protein linked at the c-terminus of a cytotoxic t-cell epitope from the m2 protein of respiratory syncytial virus efficiently primes for an major histocompatibility complex (mhc) class-i restricted cytotoxic t lymphocyte (ctl) response. in this report, we demonstrated by microspectrofluorometry that the fusion-peptide moiety bound to the plasma membra ... | 1997 | 9395341 |
| evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children. | two live-attenuated, cold-passaged (cp), temperature-sensitive (ts) candidate vaccines, designated cpts530/1009 and cpts248/955, were attenuated, genetically stable, and immunogenic in chimpanzees and were highly attenuated for human adults. in respiratory syncytial virus (rsv)-seropositive children, cpts530/1009 was more restricted in replication than cpts248/955. in seronegative children, 10(4) pfu of cpts248/955 was insufficiently attenuated, and a high titer of vaccine virus was shed (mean p ... | 1997 | 9395351 |
| rate of seasonal spread of respiratory syncytial virus in a pediatric hospital. | the rate of nosocomial respiratory syncytial virus (rsv) infection was measured in a large pediatric hospital using an incidence density method. the at-risk days for nosocomial rsv were summed during a defined winter period in which there were 54 admissions with community-acquired rsv infection giving a rate of 2.9 cases per 1,000 at-risk days (95% confidence interval, 0.3-5.4 per 1,000). | 1997 | 9397377 |
| negative regulation of a heterologous promoter by human cytomegalovirus immediate-early protein ie2. | the hcmv ie2 protein promiscuously activates transcription of many viral and cellular genes. ie2 also negatively autoregulates its own expression by binding to a strategically positioned ie2 binding site, called crs, located immediately downstream of the tata box of the hcmv major ie promoter. here we show that ie2 is able to repress transcription driven by a heterologous promoter, rsv ltr. repression of rsv ltr by ie2 is completely dependent of dna sequences downstream of the tata box of rsv lt ... | 1997 | 9400610 |
| recombinant vaccinia viruses expressing the f, g or n, but not the m2, protein of bovine respiratory syncytial virus (brsv) induce resistance to brsv challenge in the calf and protect against the development of pneumonic lesions. | the immunogenicity and protective efficacy of recombinant vaccinia viruses (rvv) encoding the f, g, n or m2 (22k) proteins of bovine respiratory syncytial virus (brsv) were evaluated in calves, the natural host for brsv. calves were vaccinated either by scarification or intratracheally with rvv and challenged 6 to 7 weeks later with brsv. although replication of rvv expressing the f protein in the respiratory tract was limited after intratracheal vaccination, the levels of serum and pulmonary an ... | 1997 | 9400970 |
| secretory igm and iga antibodies to respiratory syncytial virus in nasopharyngeal aspirates: a diagnostic supplement to antigen detection. | rsv-shedding during an rsv-infection declines dramatically after the first week of infection. it could be of interest to be able to diagnose rsv-infection for a longer period of time by detection of specific rsv-igm and rsv-iga in nasopharyngeal aspirates (npa) in order to minimize unnecessary antibiotics. | 1997 | 9406652 |
| rapid detection of different rna respiratory virus species by multiplex rt-pcr: application to clinical specimens. | the polymerase chain reaction (pcr) applied in diagnostic and epidemiologic investigations is very useful for sensitivity, specificity and time saving. | 1997 | 9406653 |
| improved detection of respiratory syncytial virus in nasal aspirates by seminested rt-pcr. | a seminested rt-pcr for amplification of respiratory syncytial virus (rsv)-rna in nasal aspirates has been developed and used to test nasopharyngeal aspirates (npas) from 132 infants hospitalized with acute respiratory tract infections during winter epidemics. the results were compared with those obtained by virus isolation in tissue culture and antigen detection with an enzyme-linked immunosorbent assay (ag-elisa). rsv-rna was detected by seminested rt-pcr in 57 of the 59 samples that were posi ... | 1997 | 9407385 |
| update: respiratory syncytial virus activity -- united states, 1997-98 season. | respiratory syncytial virus (rsv), a common cause of winter outbreaks of acute respiratory disease, results in an estimated 90,000 hospitalizations and 4500 deaths each year from lower respiratory tract disease among infants and young children in the united states. outbreaks occur annually throughout the country. rsv activity in the united states is monitored by the national respiratory and enteric virus surveillance system (nrevss), a voluntary, laboratory-based system. this report summarizes t ... | 1997 | 9408044 |
| respiratory syncytial virus prevent study questions. | 1997 | 9411385 | |
| respiratory syncytial virus prevent study questions. | 1997 | 9411386 | |
| respiratory syncytial virus prevent study questions. | 1997 | 9411387 | |
| immunization of cattle with a bhv1 vector vaccine or a dna vaccine both coding for the g protein of brsv. | a ge-negative bovine herpesvirus 1 (bhv1) vector vaccine carrying a gene coding for the g protein of bovine respiratory syncytial virus (brsv) (bhv1/brsv-g) induced the same high degree of protection in calves against brsv infection and bhv1 infection as a multivalent commercial vaccine. a dna plasmid vaccine, carrying the same gene as the bhv1/brsv-g vaccine, significantly reduced brsv shedding after brsv infection compared with that in control calves, but less well than the bhv1/brsv-g vaccine ... | 1997 | 9413101 |
| the impact of cetirizine on microbial and viral infections. | 1997 | 9413630 | |
| the product of the respiratory syncytial virus m2 gene orf1 enhances readthrough of intergenic junctions during viral transcription. | the mrna encoding the m2 protein of respiratory syncytial (rs) virus contains two open reading frames (orfs). orf1 encodes the 22-kda structural protein, m2, and orf2 has the potential to encode a 10-kda protein (90 amino acids). using a vaccinia virus t7 expression system, we examined the rna synthetic activities of mono- and dicistronic subgenomic replicons of rs virus by direct metabolic labeling of rna in the presence and absence of the products of orf1 and orf2. in the absence of orf1 and o ... | 1998 | 9420254 |
| prophylactic administration of a complementarity-determining region derived from a neutralizing monoclonal antibody is effective against respiratory syncytial virus infection in balb/c mice. | immunotherapy with antibodies against respiratory syncytial virus (rsv) is a treatment option given the absence of any vaccine or other available satisfactory treatment. we selected one of our monoclonal antibodies, rs-348, that is highly neutralizing. we showed that a single peptide (pep3h) derived from complementarity-determining region 3 (cdr3) of its heavy chain was capable of neutralizing the virus in vitro. when intranasally administered 24 h before challenge, this peptide protected balb/c ... | 1998 | 9420291 |
| respiratory syncytial virus infection of neonatal monocytes stimulates synthesis of interferon regulatory factor 1 and interleukin-1beta (il-1beta)-converting enzyme and secretion of il-1beta. | interleukin-1beta (il-1beta) production in response to respiratory syncytial virus (rsv) was investigated in normal neonate monocytes. intracellular or culture supernatant il-1beta protein levels were measured by enzyme immunoassay. the expression of mrnas for interferon regulatory factor 1 (irf-1), il-1beta-converting enzyme (ice), and il-1beta in the cells was analyzed semiquantitatively by reverse transcriptase-pcr. before rsv exposure, some irf-1, ice, and il-1beta transcripts were already e ... | 1998 | 9420296 |
| respiratory syncytial virus infection in infants and young children. | respiratory syncytial virus (rsv) is the most common cause of lower respiratory tract infections in infants and young children. epidemics occur yearly from december to march or april, leading to 100,000 hospitalizations in the united states at an estimated cost of $300 million. physical examination findings may include clear coryza, evidence of respiratory distress, wheezing, and dehydration. complications include apnea. mortality runs as high as 0.5% to 1.5% in hospitalized patients. diagnosis ... | 1997 | 9420581 |
| prevention and treatment recommendations for respiratory syncytial virus infection. background and clinical experience 40 years after discovery. | though 40 years have passed since its discovery, respiratory syncytial virus (rsv), one of the most ubiquitous viruses known, continues to evade most of our efforts to prevent or treat the clinical disease it causes. long recognised as the most common cause of lower respiratory tract infections in virtually all children in the first 2 years of life, it has been increasingly recognised as a cause of more serious disease in several 'high risk' populations. these populations include infants with ca ... | 1997 | 9421694 |
| what clinicians need to know about antiviral drugs and viral resistance. | the development of safe and effective antiviral therapies for the management of a variety of viral infections has expanded tremendously in recent years. treatment is now possible for serious and potentially life-threatening infections with herpesviruses, respiratory viruses such as influenza a and respiratory syncytial virus, and the human immunodeficiency virus. the increased availability and use of antiviral drugs, however, has led to the emergence of drug-resistant viruses, especially in immu ... | 1997 | 9421709 |
| respiratory syncytial virus-immunoglobulin intravenous (rsv-igiv) for respiratory syncytial viral infections: part i. | rsv is a highly contagious, devastating disease, especially in high-risk infants. rsv infection typically presents as an upper respiratory tract infection and then may progress to the lower respiratory tract, causing pneumonia and bronchiolitis. the signs, symptoms, and severity of rsv infection vary with age and the number of previous rsv infections. young age, premature birth, a crowded living environment, day care attendance, and exposure to passive smoking are risk factors for more severe rs ... | 1997 | 9423415 |
| [detection of chlamydia trachomatis in children with acute lower respiratory infection]. | diagnosis of respiratory tract infections due to chlamydia trachomatis in pediatric patients is very important because of its complications and sequelae. the aim of the present study was to evaluate the performance of rapid methods for reading this diagnosis in 111 children with lower acute respiratory disease. | 1997 | 9424120 |
| cells and mediators from pharyngeal secretions in infants with acute wheezing episodes. | an acute wheezing episode is the most common feature of severe lower respiratory tract infection during infancy. respiratory syncytial virus (rsv) is the major causative agent. in order to study inflammation during acute wheezing episodes in infants, we wanted to assess the feasibility and contribution of induction of pharyngeal secretions. we therefore compared inflammatory markers in the pharyngeal secretions of 27 infants suffering from acute wheezing episodes with an rsv infection (rsv+) and ... | 1997 | 9426101 |
| respiratory syncytial virus bronchiolitis: a double-blind dexamethasone efficacy study. | the efficacy of dexamethasone therapy for primary respiratory syncytial virus bronchiolitis was studied in a double-blind placebo design in 29 previously healthy infants (median age, 194 days). no significant differences were found between the groups in evolution of respiratory rate, oxygen saturation, clinical score, or pulmonary function tests on day 3. | 1997 | 9427901 |
| rsv specimen collection methods: nasal vs. nasopharyngeal. | to compare two types of specimen collection methods for rsv (respiratory syncytial virus): nasal wash and nasopharyngeal wash. | 1997 | 9429523 |
| animal models of respiratory syncytial virus infection. | over the past two decades, animal models of respiratory syncytial virus (rsv) infection have been developed using primates, cotton rats, mice, calves, guinea pigs, ferrets, and hamsters. use of these models has shed light on the mechanisms of vaccine-enhanced disease seen in clinical trials of a formalin-inactivated rsv vaccine and has provided a means for testing efficacy and safety of candidate prophylactic and therapeutic strategies. the development of multiple animal models has coincided wit ... | 1997 | 9431379 |
| [respiratory syncytial viruses: viral characteristics and epizootiology of the disease]. | human respiratory syncytial virus (hrsv) is the major respiratory tract pathogen of infants and young children. bovine respiratory syncytial virus (brsv) is recognized as an important cause of respiratory tract disease in calves. both these viruses and their respective diseases share many similarities. after a description of the general properties of the virus, this review covers the epizootology of bovine respiratory syncytial virus infection. | 1997 | 9441497 |
| [respiratory syncytial viruses: pathogenesis, immunology and disease prevention]. | immunopathologic mechanism has been proposed to be involved in the pathogenesis of respiratory syncytial virus infections. this review examines the current understanding of the role of immunopathologic mechanisms in rsv infections. the role of vaccines in inducing hypersensitivity is also discussed. | 1997 | 9441498 |
| nosocomial respiratory syncytial virus infection in a newborn nursery. | respiratory syncytial virus (rsv) has been recognized as a major nosocomial hazard on pediatric wards, but symptomatic rsv infection is uncommon during the first four weeks of life. we report here four cases of neonatal rsv infection in a special-care newborn nursery and two of them probably acquired the infection nosocomially. by rapid diagnosis using immunofluorescent technique and early implementation of infection control measures, we were able to prevent further spread of rsv infection. | 1997 | 9443085 |
| the ns1 protein of human respiratory syncytial virus is a potent inhibitor of minigenome transcription and rna replication. | the ns1 protein (139 amino acids) is one of the two nonstructural proteins of human respiratory syncytial virus (rsv) and is encoded by a very abundant mrna transcribed from the promoter-proximal rsv gene. the function of ns1 was unknown and was investigated here by using a reconstituted transcription and rna replication system that involves a minireplicon and viral proteins (n, p, l and m2-1) expressed from separate cotransfected plasmids. coexpression of the ns1 cdna strongly inhibited transcr ... | 1998 | 9445048 |
| essential roles of nf-kappab and c/ebp in the regulation of intercellular adhesion molecule-1 after respiratory syncytial virus infection of human respiratory epithelial cell cultures. | to determine the molecular mechanism(s) of respiratory syncytial virus (rsv)-induced intercellular adhesion molecule-1 (icam-1) upregulation in respiratory epithelial cells (rec; a549 cell cultures), we investigated the roles of the transcription factors nf-kappab and c/ebp. increases in icam-1 message required de novo mrna synthesis. icam-1 promoter constructs (luciferase reporter gene) transfected into a549 monolayers demonstrated promoter activation following rsv infection. activation was abo ... | 1998 | 9445067 |
| influenza surveillance in england and wales: october 1996 to june 1997. | this report summarises information collected for the surveillance of influenza in england and wales during the winter of 1996/97. consultations for 'influenza and influenza-like illness' with sentinel general practitioners in england and wales began to increase towards the end of november and peaked at the start of january. in england, consultations for 'aggregated respiratory disease' (ard) began to increase a little earlier, perhaps as a result of increased respiratory syncytial virus activity ... | 1997 | 9447787 |
| from the centers for disease control and prevention. update: respiratory syncytial virus activity--united states, 1997-98 season. | 1998 | 9450698 | |
| analysis of the bovine respiratory syncytial virus fusion protein (f) using monoclonal antibodies. | seven monoclonal antibodies (mabs) directed against bovine respiratory syncytial virus (brsv) fusion (f) protein were produced and characterized by radioimmunoprecipitation and immunofluorescence assays. these seven mabs together with the previously described mabs (beeler and van wyke coelingh, 1989) to the f protein of human respiratory syncytial virus (hrsv) were used to study the antigenic variation of 12 strains of ungulate rsv. all except one mabs specific for the hrsv-f protein reacted wit ... | 1997 | 9453129 |
| reduction of respiratory syncytial virus titer in the lungs of mice after intranasal immunization with a chimeric peptide consisting of a single ctl epitope linked to a fusion peptide. | in the work described here, the effect of intranasal immunization of balb/c mice with synthetic chimeric peptides consisting of a cytotoxic t-cell epitope (amino acids 81-95) from the m2 protein of respiratory syncytial virus (rsv) and a fusion peptide (amino acids 113-131) from the f1 protein of measles virus on response to challenge with rsv has been assessed. three intranasal immunizations with the chimeric peptides without adjuvant induce peptide- and rsv-specific cytotoxic t-cell responses ... | 1998 | 9454711 |
| effectiveness of rsv-ig in premature infants: potential pitfalls in clinical settings. | 1998 | 9457162 | |
| serological evidence for pneumovirus infections in pigs. | a serological survey was carried out on pig sera from herds in northern ireland to investigate the incidence of reactivity to bovine respiratory syncytial virus (brsv) antigens. a total of 529 pig sera from 61 herds were tested and 219 (41 per cent) were found to be reactive with brsv-infected cell cultures in an indirect immunofluorescence test. none of the brsv-reactive sera immunostained turkey rhinotracheitis virus-infected cell cultures, indicating specificity for brsv epitopes. the specifi ... | 1998 | 9460216 |
| cd8+ t cells control th2-driven pathology during pulmonary respiratory syncytial virus infection. | balb/c mice vaccinated with vaccinia virus expressing the major surface glycoprotein g of respiratory syncytial virus (rsv) develop lung eosinophilia during rsv challenge. the g protein is remarkable in that it induces cd4+, but no cd8+ t cells in this mouse strain. studies using passive t cell transfers show that co-injection of cd8+ t cells greatly reduces the th2-driven lung eosinophilia caused by g-specific cd4+ t cells. by contrast, vaccination with the fusion protein (f) induces both cd8+ ... | 1997 | 9464822 |
| respiratory syncytial virus affects pulmonary function in balb/c mice. | balb/c mice inoculated intranasally with respiratory syncytial virus (rsv) were studied in a whole-body plethysmograph to determine if signs of respiratory illness similar to those observed in human infants could be detected. also, responsiveness to methacholine was assessed. rsv-infected mice showed significantly higher respiratory rates than did controls (409.2 vs. 305.2 breaths/min, p < .0001). significantly increased airway responsiveness to methacholine was noted, infected mice responding t ... | 1998 | 9466511 |
| relationship of serum antibody to risk of respiratory syncytial virus infection in elderly adults. | the relationship of serum antibody to respiratory syncytial virus (rsv) and risk of rsv infection was prospectively evaluated in frail elderly persons. baseline blood samples from 22 subjects who developed symptomatic rsv infection during the 26-month study and from 22 control subjects who did not become infected with rsv were compared. the mean serum igg titer to rsv fusion protein was significantly lower in the rsv-infected group than in the controls (15.4 +/- 1.6 vs. 16.4 +/- 1.8, p = .05), a ... | 1998 | 9466538 |
| safety and immunogenicity of a purified f protein respiratory syncytial virus (pfp-2) vaccine in seropositive children with bronchopulmonary dysplasia. | respiratory syncytial virus (rsv) causes serious respiratory illness in preterm children with bronchopulmonary dysplasia. in a prospective randomized placebo-controlled trial, 21 children received one dose of pfp-2 (purified fusion [f] protein) vaccine or influenza vaccine (placebo). children were followed for adverse reactions and rsv illness over two respiratory seasons. sera were obtained for determination of igg titers to rsv f protein and neutralizing antibody titers before and 1, 6, and 12 ... | 1998 | 9466539 |
| viruses and bacteria in the etiology of the common cold. | two hundred young adults with common colds were studied during a 10-month period. virus culture, antigen detection, pcr, and serology with paired samples were used to identify the infection. viral etiology was established for 138 of the 200 patients (69%). rhinoviruses were detected in 105 patients, coronavirus oc43 or 229e infection was detected in 17, influenza a or b virus was detected in 12, and single infections with parainfluenza virus, respiratory syncytial virus, adenovirus, and enterovi ... | 1998 | 9466772 |
| respiratory syncytial virus pneumonitis-induced diffuse alveolar damage in an autologous bone marrow transplant recipient. | a 24-year-old woman with recurrent hodgkin's lymphoma, stage iib nodular sclerosing type, underwent an autologous bone marrow transplantation. forty-five days after transplantation, an upper respiratory tract infection developed that progressed to respiratory distress necessitating mechanical ventilation. an open-lung biopsy demonstrated diffuse alveolar damage. after an extensive search for the cause of the respiratory compromise, we detected respiratory syncytial virus in a bronchoalveolar lav ... | 1998 | 9472999 |
| respiratory syncytial virus. | 1998 | 9473944 | |
| respiratory syncytial virus immune globulin intravenous (human) receives marketing approval in canada. | 1998 | 9481469 | |
| local variability in respiratory syncytial virus disease severity. | respiratory syncytial virus (rsv) lower respiratory tract infections are considered to be a serious disease in centres such as the sophia children's hospital (rotterdam, the netherlands), but as more benign infections in others such as the geneva children's hospital (switzerland). to assess the clinical severity of rsv infections at the two sites, 151 infants primarily admitted with a virologically confirmed rsv infection were studied prospectively (1994-5) and retrospectively (1993-4) (55 infan ... | 1997 | 9487963 |
| [virus-bacteria co-infections]. | influenza is the best known model of bacterial-viral co-infection. epidemics of influenza result in an increased hospital admission rate for bacterial pneumonia due to pneumococcus, haemophilus influenzae and staphylococcus aureus. similarly, an increased incidence of meningococcal diseases, particularly severe forms, follows the influenza outbreaks, with a two week delay. though the precise mechanism is not known, the depression of host's phagocytes bactericidal activity by the influenza virus ... | 1997 | 9488749 |
| safety, tolerance and pharmacokinetics of a humanized monoclonal antibody to respiratory syncytial virus in premature infants and infants with bronchopulmonary dysplasia. medi-493 study group. | respiratory syncytial virus (rsv) is the most common cause of lower respiratory tract infection in infants. medi-493 (palivizumab) is a humanized monoclonal antibody to the fusion protein of rsv and is active in animal models for prevention of pulmonary rsv replication. | 1998 | 9493805 |
| experimental researches in infections with associated myxoviruses in the mouse. | infections with influenza virus, a/beijing 353/89 (h3n2) strain, to which there were associated parainfluenza virus type 3, 739-2d strain, adenovirus type 3, and respiratory syncytial virus long strain, were experimentally induced in white mice. the experimental models were set up so as to permit the obtaining of an associated infection with three viruses, in which the influenza virus should be inoculated the first, the participation of the others being variable, according to their presence by a ... | 1996 | 9495782 |
| some virological and pathomorphological aspects of the respiratory system in the experimental infection with respiratory syncytial virus associated with influenza virus, parainfluenza virus type 3 and adenovirus in the mouse. | infections with respiratory syncytial virus long strain, associated with influenza virus, a/beijing 353/89 (h3n2) strain, parainfluenza virus type 3, 739-2d strain, and adenovirus type 3, were experimentally induced in white mice, causing histological, histochemical and histoenzymatic lesions at the respiratory system level, the severity of which exceeded the one observed in the controls infected with a single virus. the pathomorphological changes made up an inflammatory, predominantly infiltrat ... | 1996 | 9495783 |
| respiratory syncytial virus genotypes and disease severity among children in hospital. | to determine the spectrum of n and g genotypes of respiratory syncytial virus (rsv) causing respiratory tract infection and whether particular genotypes are associated with severity of infection. | 1997 | 9496185 |
| a peptide mimic of a protective epitope of respiratory syncytial virus selected from a combinatorial library induces virus-neutralizing antibodies and reduces viral load in vivo. | respiratory syncytial virus (rsv) is the most important cause of bronchiolitis and pneumonia in infants and young children worldwide. as yet, there is no effective vaccine against rsv infection, and previous attempts to develop a formalin-inactivated vaccine resulted in exacerbated disease in recipients subsequently exposed to the virus. in the work described here, a combinatorial solid-phase peptide library was screened with a protective monoclonal antibody (mab 19) to identify peptide mimics ( ... | 1998 | 9499058 |
| autocrine regulation and experimental modulation of interleukin-6 expression by human pulmonary epithelial cells infected with respiratory syncytial virus. | the mechanisms of regulation of interleukin-6 (il-6) production in respiratory syncytial virus (rsv)-infected respiratory epithelial cells were evaluated in a549 cell cultures. incubation with purified rsv resulted in significant production of il-1alpha, il-1beta, il-6, and tumor necrosis factor alpha (tnf-alpha). addition of saturating concentrations of neutralizing antibodies against il-1alpha, il-1beta, or tnf-alpha into purified rsv-infected cell cultures resulted in a significant inhibition ... | 1998 | 9499112 |
| [workshop on molecular epidemiology of viral diseases]. | a workshop on viral epidemiology was held on september 29, 1995 at the medical school of the universidad nacional autónoma de mexico. the aim of this workshop was to promote interaction among scientists working in viral epidemiology. eighteen scientists from ten institutions presented their experiences and work. general aspects of the epidemiology of meaningful viral diseases in the country were discussed, and lectures presented on the rota, polio, respiratory syncytial, dengue, papiloma, rabies ... | 1997 | 9504103 |
| detection of respiratory syncytial virus a and b and parainfluenzavirus 3 sequences in respiratory tracts of infants by a single pcr with primers targeted to the l-polymerase gene and differential hybridization. | a reverse transcription-pcr and hybridization-enzyme immunoassay (rt-pcr-eia) has been developed to identify the major agents of bronchiolitis in infants: respiratory syncytial viruses a and b (rsva and rsvb) and parainfluenzavirus 3 (piv3). two primer sets (p1-p2 and p1-p3) were selected in a conserved region of the polymerase l gene. in infected cell cultures, this method detected rsva (n = 14), rsvb (n = 13), and piv3 (n = 13), with the exclusion of piv1 (n = 4), piv2 (n = 3), measles virus ( ... | 1998 | 9508315 |
| respiratory syncytial virus infection in adult bmt recipients: effective therapy with short duration nebulised ribavirin. | respiratory syncytial virus (rsv), a common cause of both upper and lower respiratory tract infection (lrti) in infants and children, is rarely described as an infective agent in adults. it has been reported in bone marrow transplant (bmt) recipients and patients with malignancy immunosuppressed by chemotherapy. such reports are often associated with a high mortality. we report an outbreak of rsv infection which occurred predominantly in bmt recipients in which early investigation and institutio ... | 1998 | 9509980 |
| peds nurses prepare for rsv season. | 1998 | 9511716 | |
| respiratory syncytial virus-associated infections in adult recipients of solid organ transplants. | although respiratory syncytial virus (rsv) infection is known to cause severe pulmonary infections in bone marrow transplant recipients, less is known concerning its clinical course, diagnosis, and treatment in solid organ transplant recipients. | 1998 | 9513859 |
| antiviral drugs in healthy children. | several antiviral agents are available to treat viral illnesses in healthy children. in some children, treatment with acyclovir is an alternative to vaccination for the treatment and prevention of chickenpox. acyclovir also can be useful in the treatment or prevention of herpes simplex infections in neonates. ribavirin, once recommended as routine therapy for high-risk infants with respiratory syncytial virus disease, is now reserved for use in selected children. amantadine and rimantidine are e ... | 1998 | 9518953 |
| monoclonal antibody neutralization escape mutants of respiratory syncytial virus with unique alterations in the attachment (g) protein. | five monoclonal antibody (mab) neutralization escape mutants of respiratory syncytial virus (rsv) were produced by growing the long strain rsv (group a virus) in the presence of a neutralizing, group cross-reactive mab specific for the attachment protein (g). four viruses (rsv-2, -6, -14 and -15) had amino acid replacements clustered within a highly conserved centrally located 13 amino acid region (position 164-176). reactivity with group a-specific mabs and with polyclonal anti-g serum was main ... | 1998 | 9519826 |
| acute otitis media in children with bronchiolitis. | we investigated the prevalence and the etiology of acute otitis media (aom) in children with bronchiolitis to determine whether aom in such children is due entirely or mainly to respiratory syncytial virus (rsv), in which case routine antimicrobial treatment would not be appropriate. | 1998 | 9521943 |
| respiratory syncytial virus immunoglobulin and monoclonal antibodies in the prevention and treatment of respiratory syncytial virus infection. | respiratory syncytial virus (rsv) infection is particularly severe in infants with bronchopulmonary dysplasia (bpd) and in premature infants without bpd. attempts to develop a vaccine against rsv have been unsuccessful. passive immunoprophylaxis of premature infants with or without bpd using a hyperimmune human globulin against rsv (rsvig) decreases the severity of rsv infection such that the rate of hospitalization following infection is reduced by 40%. the severity of illness among hospitalize ... | 1998 | 9523402 |
| priming with secreted glycoprotein g of respiratory syncytial virus (rsv) augments interleukin-5 production and tissue eosinophilia after rsv challenge. | the respiratory syncytial virus (rsv) g glycoprotein promotes differentiation of type 2 cd4+ t lymphocytes and induces an eosinophilic response in lungs of rsv-infected mice. a unique feature of g is that a second initiation codon in the transmembrane region of the glycoprotein results in secretion of soluble protein from infected cells. recombinant vaccinia viruses that express wild-type g (vvwt g), only secreted g (vvm48), or only membrane-anchored g (vvm48i) were used to define the influence ... | 1998 | 9525607 |
| immunological response of mice to the bovine respiratory syncytial virus fusion glycoprotein expressed in recombinant baculovirus infected insect cells. | bovine respiratory syncytial virus (brsv) is a major cause of respiratory disease in calves. the brsv genome encodes two major glycoproteins, g and f, which are the major targets for the host antibody response. we have expressed the f glycoprotein in insect cells (sf9) using a recombinant baculovirus vector. a comparison of the f protein expressed in mammalian and insect cells by sds-page showed that only part of the baculovirus-produced protein was soluble and processed like the native protein. ... | 1996 | 9526539 |
| evaluation of a single dilution elisa system for detection of seroconversion to bovine viral diarrhea virus, bovine respiratory syncytial virus, parainfluenza-3 virus, and infectious bovine rhinotracheitis virus: comparison with testing by virus neutralization and hemagglutination inhibition. | a single-dilution quantitative enzyme-linked immunosorbent assay (elisa) system, based on commercial elisa kits, for the simultaneous detection of seroconversion to bovine viral diarrhea virus (bvdv), bovine respiratory syncytial virus (brsv), parainfluenza-3 virus (pi3v), and infectious bovine rhinotracheitis virus (ibrv) was evaluated by testing acute and convalescent serum pairs from 564 cattle in 145 outbreaks of respiratory disease. seroconversion to bvdv, brsv, pi3v and ibrv was detected i ... | 1998 | 9526859 |
| [etiology of acute lower respiratory tract infections among children younger than 5 years old in santa fe]. | the etiology of acute lower respiratory tract infections (ari) and nasopharyngeal bacterial carriage in children less than 5 years old living in santa fe city, argentina, was studied. a total of 518 children were included in the study: 450 suffering from ari and 68 asymptomatic children. blood samples, pleural effusions and nasopharyngeal secretions (ns) were obtained from children for bacterial isolations. ns was also used for fluorescent antibody techniques, and serum samples were employed for ... | 1997 | 9532829 |
| [ribavirin administration by aerosol]. | this article presents the recommended procedures to administer ribavirin by means of an aerosol as followed at the maternity-childcare university hospital in vall d'hebron, barcelona. ribavirin is a wide spectrum anitviral drug applied by aerosol means against severe infections caused by the respiratory syncytial virus. said administering technique is complex and requires a considerable degree of nursing care, knowledge regarding its correct use, and hospital care. bear in mind that careless adm ... | 1998 | 9534572 |
| passive protection of gnotobiotic calves using monoclonal antibodies directed at different epitopes on the fusion protein of bovine respiratory syncytial virus. | two neutralizing, fusion-inhibiting bovine monoclonal antibodies (mabs; b4 and b13) directed at different epitopes on the fusion protein of respiratory syncytial virus (rsv) protected the lungs of gnotobiotic calves from rsv infection. the mabs were administered intratracheally 24 h before the calves were challenged with bovine rsv. a third, nonneutralizing, non-fusion-inhibiting but complement-fixing mab, b1, provided no significant protection against infection, and the disease was not exacerba ... | 1998 | 9534958 |
| isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (fab rsvf2-5) that exhibits therapeutic efficacy in vivo. | a second human respiratory syncytial virus (rsv)-neutralizing monoclonal antibody was isolated and its binding site was identified. fab f2-5 is a broadly reactive fusion (f) protein-specific recombinant fab generated by antigen selection from a random combinatorial library displayed on the surface of filamentous phage. in an in vitro plaque-reduction test, the fab rsvf2-5 neutralized the infectivity of a variety of field isolates representing viruses of both rsv subgroups a and b. the fab recogn ... | 1998 | 9534985 |
| sequential annual administration of purified fusion protein vaccine against respiratory syncytial virus in children with cystic fibrosis. | we recently showed the clinical benefit of the pfp-2 vaccine for respiratory syncytial virus (rsv) for children with cystic fibrosis (cf). | 1998 | 9535249 |
| the clinical spectrum of respiratory syncytial virus disease in the gambia. | respiratory syncytial virus (rsv) is a well-recognized cause of lower respiratory tract infections in early childhood in industrialized countries, but less is known about rsv infection in developing countries. | 1998 | 9535250 |
| international variation in the management of infants hospitalized with respiratory syncytial virus. international rsv study group. | respiratory syncytial virus (rsv) is a frequent cause of hospitalization among infants. to compare patient management in europe, the united states, and australia, we analyzed the charts of 1,563 pediatric patients hospitalized with laboratory-confirmed rsv lower respiratory infections during recent rsv seasons. half of patients had been seen initially as outpatients. median duration of hospitalization was 4 days in australia, finland, the united kingdom, and the united states, and 8 or 9 days in ... | 1998 | 9537488 |
| expression of the neutrophil chemoattractant interleukin-8 in the lesions of bovine pneumonic pasteurellosis. | we investigated the expression of interleukin-8 (il-8) in pneumonic pasteurellosis of cattle because neutrophils are important mediators of tissue injury in this disease and because il-8 is a major neutrophil chemoattractant in other species. we also compared il-8 expression in bacterial and viral pneumonia, since the latter lacks the severe neutrophil exudation typical of pneumonic pasteurellosis. il-8 expression was assessed by northern analysis, in situ hybridization, enzyme-linked immunosorb ... | 1998 | 9539366 |
| identification of a conserved neutralization site in the first heptad repeat of the fusion protein of respiratory syncytial virus. | a large set of monoclonal antibodies (mabs) directed against the fusion glycoprotein complex f1f2 of bovine respiratory syncytial virus (brsv) and several polyclonal sera from infected or vaccinated animals were tested in pepscan to locate linear epitopes on the f-protein. the polyclonal sera mapped to antigenic sites that correspond exactly to known antigenic sites on the f protein of human rsv. only the neutralizing mab 3 could be mapped with pepscan. mab 3 reacted with three successive overla ... | 1998 | 9541615 |
| baculovirus expression of the fusion protein gene of bovine respiratory syncytial virus and utility of the recombinant protein in a diagnostic enzyme immunoassay. | the fusion (f) protein of bovine respiratory syncytial virus (brsv) was expressed by using a baculovirus vector. antigenicity was tested by immunofluorescence analysis with f-specific monoclonal and polyclonal antibodies. antibodies to recombinant f protein raised in a rabbit neutralized brsv and human respiratory syncytial virus infectivity when tested in a plaque reduction assay. the recombinant f protein was evaluated as a source of antigen in an enzyme-linked immunosorbent assay (elisa), and ... | 1998 | 9542947 |
| impact of influenza and other community-acquired viruses. | the incidence of community-acquired pneumonia peaks during the winter season each year. increases in mortality from these pneumonias and influenza-like illnesses (p&i) above an "epidemic threshold" for 2 or more weeks generally signify increased numbers of influenza virus infections in the community, although peaks in p&i mortality typically lag a few weeks behind peaks in influenza virus activity. most of the pneumonias cases found during influenza virus epidemics are due to secondary bacterial ... | 1998 | 9543472 |
| prevention and treatment of respiratory syncytial virus infections (for advances in pediatric infectious diseases). | 1997 | 9544306 | |
| new vaccines against mucosal pathogens: rotavirus and respiratory syncytial virus. | 1997 | 9544318 | |
| respiratory syncytial virus: a new approach to an old disease. | 1998 | 9546893 | |
| identification of two distinct populations of dendritic cells in afferent lymph that vary in their ability to stimulate t cells. | immunofluorescent staining and flow cytometric analysis of dendritic cells from cattle afferent lymph has established that within the afferent lymph veiled cells (alvc) there are two phenotypically distinct, major populations. one is cd11a+, cd5+, cd21- and expresses the bovine wc10 (workshop cluster 10) molecule and the ag recognized by mab cc81 but is not recognized by mabs cc149 and il-a24. the second alvc subpopulation is cd11a-, cd5-, cd21+/-, workshop cluster 10- and is not recognized by m ... | 1997 | 9548477 |
| hospitalization for lower respiratory disease during 20 yrs among under 5 yr old children in stockholm county: a population based survey. | lower respiratory disease (lrd) is a common cause of hospitalization in infants, and episodes of obstructive lrd increase the risk for asthma later in life. the purpose of this study was to assess time trends and geographical variation of first time hospitalization for lrd among children in stockholm county, sweden. data on first time admittance for lrd among children aged up to 5 yrs from 1973 through 1992 were obtained from the stockholm county council hospital discharge register, and populati ... | 1998 | 9551740 |
| [breast feeding for prevention of viral acute respiratory diseases in infants]. | the incidence of acute viral respiratory diseases (confirmed by immunofluorescence test) was compared in a group of 159 infants aged 0-9 months breast-fed at least once daily and in a group of 608 infants of similar age and hospitalization duration receiving only artificial food. the incidence was significantly lower in breast-fed infants (p = 0.00057), especially in the first trimester of life (p = 0.00039). this was valid of all rsv infections (p = 0.01854) and parainfluenza type 4 virus infec ... | 1997 | 9554153 |
| the effect of il-12 treatment on vaccine-enhanced illness during infection with respiratory syncytial virus. | in humans and mice, sensitisation to respiratory syncytial virus (rsv) antigens can result in severe inflammatory lung disease during subsequent infection with the virus. although specific antiviral t cells are thought to be responsible for this augmentation of disease, the precise role of different functional subsets is unknown. balb/c mice sensitised to the major surface glycoprotein (g) of rsv expressed by recombinant vaccinia virus develop th2-driven lung eosinophilia after intranasal challe ... | 1998 | 9554273 |
| community respiratory viral infection in adult lung transplant recipients. | to define the epidemiology, clinical manifestations, and long-term complications of respiratory viral infections in adult lung transplant recipients. | 1998 | 9554629 |
| respiratory syncytial virus. understanding this pediatric threat. | 1998 | 9555284 | |
| rsv, recurrent wheezing, and ribavirin. | 1998 | 9556004 | |
| reduced long-term respiratory morbidity after treatment of respiratory syncytial virus bronchiolitis with ribavirin in previously healthy infants: a preliminary report. | previously healthy infants less than 6 months of age with severe respiratory syncytial virus bronchiolitis who required hospitalization were identified from hospital records. infants had been treated either conservatively (control group, n = 19) or with ribavirin added to conservative management (study group, n = 22). all infants underwent a 1-year follow-up after the initial illness. there was a significant reduction in the prevalence of reactive airway disease in the group treated with ribavir ... | 1998 | 9556006 |