Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| vitreous penetration of orally administered gatifloxacin in humans. | to investigate the penetration of gatifloxacin, a novel extended-spectrum fluoroquinolone antibiotic, into the vitreous humor after oral administration. | 2002 | 12545689 |
| anti-inflammatory effects of erythromycin and tetracycline on propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils. | propionibacterium acnes (p. acnes), an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing neutrophil chemotactic factors (ncf). once neutrophils attracted by bacterial chemoattractants reach the inflamed site, they release inflammatory mediators such as lysosomal enzymes and reactive oxygen species (ros). previously, it has been shown that antibiotics may affect acne by means other than their anti-bacterial effects. ... | 2002 | 12546757 |
| the rationale for using a topical retinoid for inflammatory acne. | both comedogenesis and the development of inflammatory lesions in acne vulgaris appear to be related to genetic as well as immune processes. the key regulatory cytokine, interleukin-1alpha, has recently been documented as playing a major role in both the hypercornification and the orchestration of immune factors, ultimately resulting in noninflammatory and inflammatory lesions. topical retinoids, such as tretinoin, and topical retinoid analogs, such as adapalene and tazarotene, help normalize th ... | 2003 | 12553848 |
| interleukin-18. | interleukin-18 (il-18), a recently described member of the il-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. il-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers, and in the context of numerous infectious diseases. this short review will describe the basic biology of il-18 and thereafter address its potential effector and regulatory role in several human disease states including autoimmu ... | 2003 | 12554798 |
| new aspects in acne inflammation. | there is ample clinical evidence suggesting that the nervous system such as emotional stress can influence the course of acne. we examined possible participation of cutaneous neurogenic factors including neuropeptides, neuropeptide-degrading enzymes and neurotrophic factors, in association with inflammation in the pathogenesis of acne. immunohistochemical studies revealed that substance p (sp)-immunoreactive nerve fibers were in close apposition to the sebaceous glands, and that neutral endopept ... | 2003 | 12566801 |
| propionibacterium acnes resistance: a worldwide problem. | antibiotic therapy directed against propionibacterium acnes has been a mainstay of treatment for more than 40 years. despite years of widespread use of systemic tetracyclines and erythromycin, change in p. acnes sensitivity to antibiotics was not seen until the early 1980s. the first clinically relevant changes in p. acnes antibiotic sensitivity were found in the usa shortly after the introduction of topical formulations of erythromycin and clindamycin. by the late 1980s, p. acnes strains with v ... | 2003 | 12566805 |
| antibiotic-resistant propionibacteria acnes may not be the major issue clinically or microbiologically in acne. | 2003 | 12588399 | |
| propionibacterial biofilms cannot explain antibiotic resistance but might contribute to some cases of antibiotic recalcitrant acne. | 2003 | 12588400 | |
| eradication of propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. | propionibacterium acnes is a gram-positive, microaerophilic bacterium that causes skin wounds. it is known to naturally produce high amounts of intracellular porphyrins. the results of the present study confirm that the investigated strain of p. acnes is capable of producing endogenic porphyrins with no need for any trigger molecules. extracts from growing cultures have demonstrated emission peaks around 612 nm when excited at 405 nm, which are characteristic for porphyrins. endogenic porphyrins ... | 2003 | 12589953 |
| the role of innate immunity in the pathogenesis of acne. | acne is a multifactorial disease of the pilosebaceous follicle. the most significant pathogenetic factors of acne are: abnormal ductal keratinization, increased sebum secretion, abnormalities of the microbial flora and inflammation. the pilosebaceous unit is an immunocompetent organ. keratinocytes and sebocytes may act as immune cells capable of pathogen recognition and abnormal lipid presentation, and they might have an important role in initiating and perpetuating the activation of both innate ... | 2003 | 12592074 |
| aim inhibits apoptosis of t cells and nkt cells in corynebacterium-induced granuloma formation in mice. | apoptosis inhibitor expressed by macrophages (aim) inhibits apoptosis of cd4(+)cd8(+) (cd4/cd8) double-positive thymocytes, and supports the viability of these cells on the thymic selection. however, pleiotropic functions of aim have been suggested. in this study, heat-killed corynebacterium parvum (c. parvum) was injected into mice carrying the homozygous mutation (aim(-/-)) and wild-type (aim(+/+)) mice, to investigate the role of aim in the formation of hepatic granulomas. in aim(-/-) mice, t ... | 2003 | 12598318 |
| [what's new concerning the pathophysiology of acne?]. | 2003 | 12605138 | |
| [treatment of mild to moderate acne]. | 2003 | 12605143 | |
| vitreous and aqueous penetration of orally administered gatifloxacin in humans. | to investigate the penetration of gatifloxacin, a novel extended-spectrum fourth-generation fluoroquinolone antibiotic, into the vitreous and aqueous humor after oral administration. | 2003 | 12617704 |
| inhibition of propionibacterium acnes-induced mediators of inflammation by indian herbs. | propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne by inducing certain inflammatory mediators. these mediators include reactive oxygen species (ros) and pro-inflammatory cytokines. in the present study, ros, interleukin-8 (il-8) and tumor necrosis factor-alpha (tnf-alpha) were used as the major criteria for the evaluation of anti-inflammatory activity. to prove the anti-inflammatory effects of herbs, polymorphonuclear leukocytes (pmnl) and monocyt ... | 2003 | 12622461 |
| anti-acne effects of oriental herb extracts: a novel screening method to select anti-acne agents. | the acne-therapeutic effects of oriental herb extracts were investigated in terms of antichemotactic effect on polymorphonuclear leucocytes, antilipogenic actions, antibacterial activity against propionibacterium acnes and resistance induction potency in the bacteria. the ethanol extract (0.01%) of angelica dahurica markedly suppressed neutrophil chemotaxis, comparable to the effect of erythromycin (0.01%), whereas a strong antilipogenic effect was obtained with rhizoma coptidis (coptis chinensi ... | 2003 | 12637783 |
| antibiotic-resistant acne: lessons from europe. | propionibacterium acnes and p. granulosum are widely regarded as the aetiological agents of inflammatory acne. their proliferation and metabolism are controlled using lengthy courses of oral and/or topical antibiotics. despite numerous reports of skin colonization by antibiotic-resistant propionibacteria among acne patients, accurate prevalence data are available only for the u.k. | 2003 | 12653738 |
| palmitoleic acid isomer (c16:1delta6) in human skin sebum is effective against gram-positive bacteria. | the percent lipid composition of pooled human sebum analyzed by thin-layer chromatography was: ceramides (13%), fatty acid (47%), cholesterol (7%), cholesterol esters (2%), squalene (11%), triglycerides (3%), and wax esters (17%). total sebum lipids (2- 4 mg/ml), sonicated into bacterial culture medium, caused 4- to 5-fold log reduction in growth of gram-positive bacteria, staphylococcus aureus, streptococcus salivarius and the anaerobe fusobacterium nucleatum, but was ineffective against most g ... | 2003 | 12677098 |
| antibacterial therapy for acne: a guide to selection and use of systemic agents. | acne vulgaris is a very common disorder, affecting virtually every adolescent at some point in time. systemic antibacterials have been used in the treatment of acne for many years, and there are several commonly used antibacterials which have established efficacy and safety records. in recent years, the issue of antibacterials resistance has become more prominent, especially with concerns that propionibacterium acnes can transfer antibacterials resistance to other bacteria within the resident sk ... | 2003 | 12688836 |
| lumbar spondylodiscitis caused by propionibacterium acnes after epidural obstetric analgesia. | implications: we report a case of propionibacterium acnes spondylodiscitis after the placement of an epidural catheter for obstetric analgesia. this observation should alert the anesthesiologist to the fact that infection, although rare, may occur after uneventful epidural analgesia in the healthy parturient and reinforces the importance of aseptic technique during epidural catheter insertion. | 2003 | 12707154 |
| guidelines for the management of acne vulgaris in adolescents. | this article reviews the treatment of acne in adolescents. the choice of therapy should be principally based on the type of lesion and the severity of the acne, but psychosocial disability relating to the disease and the presence of scarring may also influence the approach to treatment.mild acne generally requires topical treatment only. benzoyl peroxide, azelaic acid, and antibacterials are generally used for inflammatory lesions. topical retinoids are particularly effective for noninflamed les ... | 2003 | 12716217 |
| [possible bacterial etiologies for diseases of unknown origin]. | 2003 | 12717985 | |
| increases in cytokine and antimicrobial peptide gene expression in horses by immunomodulation with propionibacterium acnes. | immunomodulation with propionibacterium acnes is used for prophylaxis of respiratory disease or in horses suffering from chronic pulmonary inflammation; however, the mechanism for this response is poorly understood. semiquantitative reverse transcriptase-polymerase chain reaction assays were used to evaluate gene expression of interleukin (il)-2, il-10, interferon (ifn)-gamma, and nk-lysin in healthy horses treated with p. acnes. findings in the study indicated that horses treated with a p. acne ... | 2003 | 12756631 |
| formation of propionibacterium acnes biofilms on orthopaedic biomaterials and their susceptibility to antimicrobials. | failure to treat and eradicate prosthetic hip infection with systemic antibiotic regimens is usually due to the fact that the infection is associated with biofilm formation and that bacterial cells growing within a biofilm exhibit increased resistance to antimicrobial agents. in this in vitro study, we investigated the susceptibility of prosthetic hip propionibacterium acnes and staphylococcus spp. isolates growing within biofilms on polymethylmethacrylate (pmma) bone cement to a range of antibi ... | 2003 | 12763449 |
| full-thickness thoracic laminar erosion after posterior spinal fusion associated with late-presenting infection. | a case report describes unilateral complete laminar erosion of the caudal thoracic spine and late-presenting infection in a patient 10 years after anteroposterior reconstruction for scoliosis. | 2003 | 12768158 |
| lasers, light, and acne. | acne vulgaris is a highly prevalent disease with significant potential for physical and emotional scarring. acne lesions have long been noted to improve after exposure to sunlight. this improvement may be secondary to activation of endogenous porphyrins produced by propionibacterium acnes. recently, several investigators have presented studies in which light of particular wavelengths has been used to treat acne vulgaris. in this article, we review the results of these studies as we look to the f ... | 2003 | 12769401 |
| pacemaker endocarditis due to propionibacterium acnes. | propionibacterium acnes belongs to the cutaneous flora of humans; it is often considered to be contaminant but has also been found to be a pathogen in human diseases. it is an uncommon causal agent in infective endocarditis and appears to have a predilection for prosthetic valves and foreign bodies. we describe a case of pacemaker endocarditis which shows that so-called harmless bacteria like p. acnes must be considered to be potential pathogens. | 2003 | 12789479 |
| identification and purification of immunogenic proteins from nonliving promastigote polyvalent leishmania vaccine (leishvacin ). | immunogenic proteins from nonliving promastigote polyvalent leishmania vaccine against american tegumentary leishmaniasis (leishvacin ), produced by biobr s (biochemistry of brazil ), montes claros, state of minas gerais, brazil, were identified and purified by polyacrylamide electrophoresis gel and electroelution. c57bl/10 mice were vaccinated with proteins with estimated molecular weights of 42, 46, 63, 66, 73, 87, 97, and 160kda in three doses of 30 g of each protein at 15-day intervals combi ... | 2003 | 12806454 |
| increased antimicrobial resistance in organisms recovered from otitis media with effusion. | previous studies concerning the microbiology of otitis media with effusion (ome) did not correlate the past use of antimicrobial agents with the recovered organism's antimicrobial susceptibility. a retrospective analysis of cultures obtained from aspirates of 129 children with ome was performed. the study identified the isolated organisms and determined their susceptibility to the most recently administered antimicrobials. bacterial growth was noted in 58 (45 per cent) patients. aerobic organism ... | 2003 | 12818052 |
| subacute propionibacterium acnes osteomyelitis of the spine in an adolescent. | moderate to severe facial acne is caused by infection with propionibacterium acnes, an organism that has also been implicated in subacute osteomyelitis. the symptoms are often indolent in nature, but slowly progressive. we present a case report of subacute p. acnes osteomyelitis at our institution. a high index of suspicion and an extended incubation time are required for diagnosis. treatment usually requires irrigation and debridement, with or without antibiotics. | 2003 | 12821847 |
| the effective treatment of acne vulgaris by a high-intensity, narrow band 405-420 nm light source. | available topical treatments are slow and frequently irritating. oral therapies may be associated with increased bacterial resistance (antibiotics) or possible severe side effects (oral isotretinoin). in vitro and in vivo exposure of acne bacteria to 405-420 nm ultraviolet (uv) free blue light results in the photo-destruction of these bacteria through the effects on the porphyrins produced naturally by propionibacterium acnes. a novel, high-intensity, narrow band 420 nm uv free blue light has be ... | 2003 | 12850803 |
| estimation of bacterial risk in extending the shelf life of plt concentrates from 5 to 7 days. | the use of bacterial culture to prevent bacterial contamination of blood components has renewed interest for extending the shelf life of plt concentrates to 7 days after collection. | 2003 | 12869109 |
| proton magic angle spinning nmr reveals new features in photodynamically treated bacteria. | the bacterium propionibacterium acnes is light-sensitive due to porphyrin-induced photosensitization. the light sensitivity increases with incubation of 5-aminolevulinic acid, ala. for the first time, 1h magic angle spinning nmr spectroscopy is used to describe the photoinduced changes in the bacterium after ala incubation. successful photosensitization was performed with light-emitting diodes in the blue and red regions (430 and 654 nm, respectively). the irradiation setup, suitable for irradia ... | 2003 | 12872936 |
| effects of endotoxin tolerance on propionibacterium acnes-primed lipopolysaccharide hepatic injury. | prior administration of the gram-positive bacteria propionibacterium acnes (pa) results in hypersensitivity and hepatocyte necrosis to a subsequent low dose of lipopolysaccharide (lps). endotoxin tolerance has been shown to prevent lethality after ischemia/reperfusion injuries, sepsis, and endotoxic shock. we investigated whether prior induction of lps tolerance could prevent subsequent pa-priming and lps-induced death. the levels of known effector cytokines possibly responsible for these change ... | 2003 | 12873441 |
| treatment with propionibacterium acnes modulates the late phase reaction of immediate hypersensitivity in mice. | the administration of killed propionibacterium acnes suspension to mice enhances macrophage phagocytic and tumoricidal activities, have an adjuvant effect to antibody response and increases resistance to infection. recent reports demonstrated that p. acnes treatment promotes il-12 and il-18 synthesis in mice inducing ifn-gamma release, enhancement of igg2a switch and inhibition of th2 cell expansion. these findings led us to investigate whether p. acnes could modulate hypersensitivity type i rea ... | 2003 | 12880687 |
| nuclear factor kappa b decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. | endotoxin syndrome is a systemic inflammatory response mediated by inflammatory cytokines. nuclear factor kappa b (nf-kappa b) is the dominant regulator of the production of these cytokines by inflammatory cells. the aim of this study was to assess the efficacy of in vivo transfer of synthetic double-stranded oligodeoxynucleotides (odn) with high affinity against nf-kappa b (nf-kappa b/decoy/odn) as a therapeutic strategy for treating endotoxin-induced fatal liver injury. liver injury was induce ... | 2003 | 12883477 |
| kupffer cell-mediated recruitment of dendritic cells to the liver crucial for a host defense. | tissue recruitment of dendritic cells (dcs) is essential for antigen presentation. when latex particulates were injected intravenously into rats, dc precursors were recruited to the liver. propionibacterium acnes also induced the recruitment of definite mouse dc precursors. these dcs initially showed a selective binding to kupffer cells. in the kupffer cell-depleted rats, dcs could neither be recruited to the liver nor adhere to sinusoidal walls. pretreatment with varied monosaccharides in vitro ... | 2002 | 12885155 |
| current concepts of the pathogenesis of acne: implications for drug treatment. | the pathogenesis of acne is complex, with strong evidence supporting the involvement of sebaceous hyperplasia, follicular hyperkeratinisation, bacterial hypercolonisation, as well as immune reactions and inflammation. high sebum concentrations and follicular hyperkeratinisation lead to a change of the follicular milieu with consecutive proliferation of bacteria, chiefly propionibacterium acnes. this leads to further increased production of the pro-inflammatory cytokines interleukin-1alpha and tu ... | 2003 | 12887264 |
| open globe injuries with positive intraocular cultures: factors influencing final visual acuity outcomes. | to investigate the clinical features influencing final visual acuity outcomes of eyes with positive intraocular cultures after open globe injuries. | 2003 | 12917173 |
| [sarcoidosis and propionibacterium acnes]. | 2003 | 12924260 | |
| pathological mechanisms of acne with special emphasis on propionibacterium acnes and related therapy. | acne is a common disease that in cases of extreme disfiguration can have severe consequences for the personality development of young people and is associated with a relatively high prevalence of depression and suicide. spontaneous regression is common, but acne can extend into the fourth and fifth decades of life. the pathogenesis is still not fully understood. factors promoting the development of acne are: increased sebum production, ductal cornification, bacterial colonization of the piloseba ... | 2003 | 12926793 |
| severe infective keratitis leading to hospital admission in new zealand. | to identify key risk factors and the management and outcome of severe infective keratitis leading to public hospital admission in new zealand. | 2003 | 12928276 |
| propionibacterium acnes endophthalmitis diagnosed by microdissection and pcr. | 2003 | 12928300 | |
| generation and characterization of mice transgenic for human il-18-binding protein isoform a. | interleukin (il)-18 binding protein (il-18bp) is a natural inhibitor of the pleiotropic cytokine il-18. to study the role of il-18bp in modulating inflammatory responses in vivo, mice transgenic for human il-18bp isoform a (il-18bp-tg) were generated. the transgene was expressed at high levels in each organ examined. high levels of bioactive human il-18bpa were detectable in the circulation of il-18bp-tg mice, which were viable, fertile, and had no tissue or organ abnormality. the high levels of ... | 2003 | 12960225 |
| tnf revisited: tnf-independent antitumor activity in sera of mice sensitized with propionibacterium acnes and challenged with lipopolysaccharide. | sera of mice sensitized with bacteria and subsequently challenged with lipopolysaccharide promote hemorrhagic necrosis of tumors in vivo and display cytotoxic activity against tumor cells in vitro, which has been attributed to the induction of tumor necrosis factor (tnf). here, we describe the induction of a previously unrecognized antitumor activity in such sera, which is distinct from tnf but displays tumor-specific cytocidal activity in vitro as well as potent tumor-regressing activity in viv ... | 2003 | 12960265 |
| [comparative study on six bacterial anaerobic non-sporulated strains: actinomyces bovis (bovine), actinomyces bovis (human), actinomyces israeli var. liquefaciens, corynebacterium acnes, corynebacterium avidum and corynebacterium liquefaciens]. | 1953 | 13148703 | |
| [serology of anaerobic corynebacteria. ii. serology and pathogenetic significance of corynebacterium acnes]. | 1957 | 13531667 | |
| hypersensitivity to corynebacterium acnes. | 1961 | 13730666 | |
| antibiotic sensitivity of corynebacterium acnes (propionibacterium acnes). | 1961 | 13736431 | |
| [antigenic study of corynebacterium acnes by the passive hemagglutination test. antigens in common with other corynebacteria]. | 1960 | 13855618 | |
| aerobic and anaerobic bacterial counts of nasal washings: presence of organisms resembling corynebacterium acnes. | watson, elinor d. (washington university, st. louis, mo.), nanci j. hoffman, richard w. simmers, and theodor rosebury. aerobic and anaerobic bacterial counts of nasal washings: presence of organisms resembling corynebacterium acnes. j. bacteriol. 83:144-148. 1962.-aerobic and anaerobic colony counts in blood agar were made of 40 samples of nasal washings from five healthy adults. the anaerobic counts were consistently and significantly higher, in line with findings previously reported by others ... | 1962 | 14005288 |
| validity of propionibacterium acnes (gilchrist) douglas and gunter comb. nov. | moore, w. e. c. (virginia agricultural experiment station, virginia polytechnic institute, blacksburg) and elizabeth p. cato. validity of propionibacterium acnes (gilchrist) douglas and gunter comb. nov. j. bacteriol. 85:870-874. 1963.-atcc strains of corynebacterium acnes 11827, 6921, and 6922 were tested and consistently found to ferment lactate with the production of propionate, acetate, and succinate under strictly anaerobic conditions. atcc strains of eight species of propionibacterium ferm ... | 1963 | 14044956 |
| the pathogenic role of corynebacterium acnes in acne vulgaris. | 1963 | 14071457 | |
| studies on the corynebacterium acnes. | 1964 | 14154722 | |
| study of antibody levels to corynebacterium acnes. in the serum of patients with acne vulgaris, using bacterial agglutination, agar gel immunodiffusion, and immunofluorescence techniques. | 1964 | 14184490 | |
| corynebacterium acnes-a cause of meningitis. | 1964 | 14232529 | |
| in vitro study of antibacterial action of various chemicals on corynebacterium acnes. | 1965 | 14301595 | |
| antibiotic resistance of propionibacterium acnes in acne vulgaris. | acne vulgaris is a common skin disease affecting all ages. antibiotics remain the most common prescribed agent for the treatment of acne. improper use of antibiotics in the dermatological setting needs to be evaluated to prevent the increasing prevalence of antibiotic resistance. | 2003 | 14515616 |
| influence of histamine in a liver injury model induced by propionibacterium acnes and lipopolysaccharide. | in normal mice, plasma histamine levels were 29.4+/-10.1 pmol/ml. when 0.1 microg of lipopolysaccharide (lps) was intravenously injected into propionibacterium acnes (p. acnes)-primed icr mice, histamine levels increased remarkably to 61.2+/-15.9 pmol/ml (p<0.001). an increase was also observed in liver tissues. oral administration of histidine at 200 mg/kg once daily for 5 d before intravenous lps injection increased the plasma alanine aminotransferase (alt) activity to 2936.5+/-356.3 iu/l, a s ... | 2003 | 14519942 |
| diagnostic management of patients with sapho syndrome: use of mr imaging to guide bone biopsy at ct for microbiological and histological work-up. | propionibacterium acnes (p. acnes) is suspected to be involved in the pathophysiology of sapho syndrome, since it has been isolated repeatedly through open surgical bone biopsy. this study demonstrates the role of mri in identifying inflamed bone areas in patients with sapho syndrome and the role of ct-guided bone biopsies in obtaining samples from these areas for microbiological and histopathological investigations, thus obviating open surgery. fourteen consecutive patients with sapho syndrome ... | 2003 | 14534805 |
| delayed postoperative intracerebral abscess caused by proprionibacterium acnes: case report and review of the literature. | a case of delayed intracerebral abscess due to proprionibacterium acnes (p. acnes), 18 months after an uneventful excision of a parasagittal haemangiopericytoma in a 61-year-old female is reported. this is highly unusual as cerebral abscess by p. acnes is rare and it occurred so late postoperatively in the absence of known risk factors. we propose the inclusion of cerebral abscess by p. acnes in the differential diagnosis of lesions that mimic tumour recurrences, after clean craniotomies. | 2003 | 14579899 |
| hydrogel patches containing triclosan for acne treatment. | adhesive hydrogel patches containing triclosan (ts) were prepared as an anti-acne dosage form. sodium polyacrylate and carboxymethylcellulose (sodium salt) were used as matrix polymers, and al(3+), produced by the reaction of dihydroxy aluminum aminoacetate and l(+)-tartaric acid, was employed as a crosslinking agent for the negatively charged polymers. the crosslinking reactions were done at 25, 40 and 50 degrees c for predetermined time intervals. the semi-solid gels were obtained only when th ... | 2003 | 14602184 |
| analysis of clinical isolates of propionibacterium acnes by optimised rapd. | random amplification of polymorphic dna (rapd) was evaluated as a genotypic method for typing clinical strains of propionibacterium acnes. rapd can suffer from problems of reproducibility if parameters are not standardised. in this study the reaction conditions were optimised by adjusting template dna concentration and buffer constituents. all isolates were typeable using the optimised rapd protocol which was found to be highly discriminatory (simpson's diversity index, 0.98) and reproducible. t ... | 2003 | 14612236 |
| molecular diagnosis of a vascular prosthesis infection, due to propionibacterium acnes, by amplification and sequencing of 16s rdna. | we describe a case of indolent vascular prosthesis infection due to propionibacterium acnes. the microorganism was identified only by amplification and sequencing of 16s rdna, while standard cultures remained negative. this observation underscores the usefulness of molecular techniques for the diagnosis of infection caused by fastidious microorganisms. | 2003 | 14616731 |
| [the influence of a new surface treatment of silicone intracoular lenses with fluoralkylsitan on the adherence of endophthalmitic bacteria in vitro]]. | dynasilan is a fluoroalkylsilan which is able to bind to surface active molecules of intraocular lenses (iols), thereby offering a new option for surface modification of silicone lenses. the purpose of this in vitro study was to investigate the influence of this new surface treatment on the adherence of two typical endophthalmitis-inducing bacteria ( staphylococcus epidermidis, propionibacterium acnes). | 2003 | 14618356 |
| propionibacterium acnes dna detected in bronchoalveolar lavage cells from patients with sarcoidosis. | the causes of sarcoidosis are unknown. propionibacterium acnes is so far the only bacterium to be found in sarcoid lymph nodes. we attempted to detect p. acnes dna in cells recovered by bronchoalveolar lavage (bal) from patients with sarcoidosis. | 2003 | 14620162 |
| microbiology's principle of biofilms as a major factor in the pathogenesis of acne vulgaris. | propionibacterium acnes reside within the pilosebaceous unit in a biofilm. as such, they live in a community of bacteria that encase themselves within an extracellular polysaccharide lining, which the organisms secrete after adherence to the surface. this gylcocalyx polymer acts as a protective exoskeleton and serves as a physical barrier, limiting effective antimicrobial concentrations within the biofilm microenvironment. the gylcocalyx polymer secreted by p. acnes as a biofilm may explain the ... | 2003 | 14636182 |
| effects of opc-6535 on lipopolysaccharide-induced acute liver injury in the rat: involvement of superoxide and tumor necrosis factor-alpha from hepatic macrophages. | the objective of this study was to investigate the effects of opc-6535 on propionibacterium acnes-primed and lipopolysaccharide-induced liver injury in the rat. | 2003 | 14639361 |
| is antibiotic resistance in cutaneous propionibacteria clinically relevant? : implications of resistance for acne patients and prescribers. | it is well recognized that some patients with acne do not respond adequately to antibiotic therapy. it is important to distinguish antibiotic recalcitrant acne which we would suggest represents acne that shows a diminished response to treatment irrespective of the cause as opposed to 'antibiotic-resistant acne' which is acne that is less responsive to treatment as a direct consequence of skin colonization with resistant propionibacteria. here we show that antibiotic-resistant acne is not just a ... | 2003 | 14640775 |
| assessment of etiologic agents in acne pathogenesis. | acne is a chronic inflammatory disease of the pilosebaceous units. traditional etiologic factors include increased sebum production, ductal hyperkeratosis, abnormality of the microbial flora within the pilosebaceous unit, and mediators of inflammation. recent developments do not refute these familial elements, but rather refine particular aspects. interleukin-1a influences hypercornification of the infundibulum as well as the inflammatory response by inducing the production of vascular endotheli ... | 2003 | 14673275 |
| subantimicrobial dose doxycycline for acne and rosacea. | acne vulgaris and rosacea present therapeutic challenges due to their chronicity, potential for disfigurement, and psychosocial impact. although pathophysiologically distinct, both conditions have major inflammatory components. consequently, topical and systemic antimicrobial agents are routinely prescribed for extended periods. emergence of resistant strains of propionibacterium acnes, adverse events, and compliance issues associated with chronic systemic tetracycline use have led to new treatm ... | 2003 | 14673277 |
| multiple bacteria in aortic aneurysms. | the purpose of the present study was to reexamine the possibility that bacteria, particularly anaerobes, are present in aortic aneurysms. | 2003 | 14681645 |
| endophthalmitis isolates and antibiotic sensitivities: a 6-year review of culture-proven cases. | to investigate the spectrum of organisms causing culture-proven endophthalmitis and their sensitivities to commonly used antimicrobial agents. | 2004 | 14700642 |
| comparison of chloroxylenol 0.5% plus salicylic acid 2% cream and benzoyl peroxide 5% gel in the treatment of acne vulgaris: a randomized double-blind study. | a 12-week double-blind randomized study was performed to compare benzoyl peroxide 5% (bp) gel and chloroxylenol 0.5% plus salicylic acid 2% (pcmx + sa) cream (nisal cream) for efficacy and adverse reactions. thirty-seven volunteers participated in the study, 19 in the bp group and 18 in the pcmx + sa group. the patients applied the medication twice daily to the entire face. clinical evaluation and lesion counts were obtained at 0, 3, 6, 9 and 12 weeks. at week 12 both groups showed a marked impr ... | 2003 | 14708455 |
| propionibacterium acnes-reactive t helper-1 cells in the skin of patients with acne vulgaris. | 2003 | 14708633 | |
| role of core biopsy in diagnosing infection before revision hip arthroplasty. | a prerevision core biopsy from a failed hip joint was performed in 41 hips (38 patients) with a high index of suspicion for sepsis to determine its efficacy in diagnosing sepsis. seven hips were known septic failures, and core biopsy was undertaken to confirm resolution of sepsis. forty hips were revised, whereas 1 hip had excision of heterotopic bone. cultures and permanent histologic sections were obtained during subsequent surgeries, and findings were compared with the results of core biopsy. ... | 2004 | 14716655 |
| studies on the cytotoxic effects of propionibacterium acnes strains isolated from cornea. | eukaryotic tissue culture appears to be a suitable model for measuring the bacterial cytotoxic effect. propionibacterium acnes strains were isolated from corneal tissue removed by keratoplastic surgery from patients with corneal dystrophy or bullous keratopathy. the cytotoxic effect of the filtrates of 10 p. acnes strains were studied by means of measuring the decrease of the mitochondrial dehydrogenase activities of viable epithelial (hela) and fibroblastic (bhk-21) cell cultures. a time and co ... | 2004 | 14726235 |
| mobilization of dendritic cell precursors into the circulation by administration of mip-1alpha in mice. | dendritic cells (dcs) play a central role in immune responses and may be useful adjuvants for tumor vaccine therapy. we previously reported that f4/80(-)b220(-)cd11c(+) dc precursors expressing the cc chemokine receptors ccr1 and ccr5 are mobilized rapidly into the circulation in mice injected with propionibacterium acnes and are recruited into inflammatory tissue by macrophage inflammatory protein 1alpha (mip-1alpha), which binds to ccr1 and ccr5. here we investigate the mechanisms of dc precur ... | 2004 | 14759987 |
| relationship between periodontal pocket sulfide levels and subgingival species. | many species implicated in the pathogenesis of periodontal disease produce volatile sulfur compounds (vsc). this investigation examined the relationship between levels of sulfide and subgingival bacterial species in the same periodontal pockets. | 2003 | 14761124 |
| cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific th1 and helminth-specific th2 responses. | to examine the ability of dendritic cells (dc) to discriminate between helminth and microbial ag and induce appropriately polarized th responses, mouse dc were copulsed with the helminth ag, schistosome egg ag (sea), along with the bacterium proprionebacterium acnes, pa, and transferred into wild-type mice. strikingly, sea/pa-copulsed dc induced concurrent pa-specific th1 (but not th2) responses and sea-specific th2 (but not th1) responses. although dc exposed to both ag undergo many of the matu ... | 2004 | 14764665 |
| augmentation of tumoricidal activity of human monocytes and macrophages by lymphokines. | monocytes were separated from peripheral blood mononuclear cells of normal human donors by adherence on plastic conditioned by cell lines (microexudate-coated plastic) and harvested by exposure to ethylene diamine tetra-acetic acid. cytolytic activity was tested by incubating effector cells for 48 h with the murine sv40-transformed tu5 kidney line or the human lung cancer-derived calu line prelabelled with tritiated thymidine. lymphokine-containing supernatants were obtained from in vitroculture ... | 1980 | 14768696 |
| resolution of persistent periapical infection by endodontic surgery. | aim: to examine the surfaces of a root tip removed during surgical endodontic treatment for the presence of microorganisms. summary: the present clinical case illustrates an endodontic retreatment of a maxillary premolar tooth with a fistula and periapical reaction. the case was under treatment for 1 year, during which an intracanal medicament was replaced several times. as the lesion did not decrease and exudate was persistent through the fistula and root canal, root end resection with root end ... | 2004 | 14870760 |
| propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis. | background: progressive macular hypomelanosis is a common hypopigmentation mainly on the central parts of the trunk, predominantly in young adults, especially women. it is often mistaken for pityriasis versicolor and pityriasis alba. it occurs in all races and has been described in many parts of the world. we discovered follicular red fluorescence restricted to lesional skin. we suspected a relation with a porphyrin-producing bacteria residing in sebum of the pilosebaceous duct, and we therefore ... | 2004 | 14967796 |
| pleurodesis for malignant pleural effusions. | approximately half of all patients with metastatic cancer develop a malignant pleural effusion which is likely to lead to a significant reduction in quality of life secondary to symptoms such as dyspnoea and cough. the aim of pleurodesis in these patients is to prevent re-accumulation of the effusion and thereby of symptoms, and avoid the need for repeated hospitalization for thoracocentesis. numerous clinical studies have been performed to try to determine the optimal pleurodesis strategy, and ... | 2004 | 14973997 |
| [treating acne: avoid the development of antibiotic resistance by applying topical and combined therapy]. | 2003 | 14974325 | |
| the use of a bacteria detection system to evaluate bacterial contamination in plt concentrates. | random-donor plts (rdps) are functional at 7 days. nevertheless, since the mid-1980s, concern for bacterial contamination has caused the storage period to be reduced to 5 days. the ability of a bacteria detection system (bds, pall) to determine bacterial contamination and permit extension of the plt shelf life to 7 days was assessed. | 2004 | 14996189 |
| evaluation of a new generation of plastic culture bottles with an automated microbial detection system for nine common contaminating organisms found in plt components. | a microbial detection system (bact/alert 3d, biomérieux [formerly organon teknika]) has previously been validated with a variety of bacterial contaminants in plts. the recovery of nine organisms seeded into plts with new plastic culture bottles was studied in comparison to the current glass bottles. the use of plastic instead of glass would be expected to reduce the risk of injury. | 2004 | 14996192 |
| in situ assessment of porphyrin photosensitizers in propionibacterium acnes. | porphyrins are known to be efficient photosensitizer molecules and the combined action of light and porphyrins in propionibacterium acnes have a lethal action on the cells. identification and quantification of in situ porphyrins in p. acnes have been done using an integrating sphere connected to an ordinary absorption spectrophotometer, and the amounts of porphyrins in the cells were quantified by measuring scattering free absorption spectra of the cell suspensions. the concentration of porphyri ... | 2004 | 15018060 |
| propionibacterium acnes lipase in seborrheic dermatitis and other skin diseases and unsei-in. | we examined propionibacterium acnes lipase in skin diseases and unsei-in. butyric acid production in axillary seborrheic dermatitis (asd) was higher than in other dermatitis, and that in acne vulgaris (av) was significantly higher than in controls. p. acnes lipase is the pathogenic factor in av and fatty acids produced by lipase might be the pathogenic factor in asd. unsei-in suppressed p. acnes lipase probably because some ingredients have antimicrobial and anti-inflammatory activities. | 2003 | 15018307 |
| antibacterial activity of ent-kaurene diterpenoids from rabdosia rosthornii. | biological activities of ent-kaurene diterpenoids, rosthornins a-d, isolated from the ether extract of the dried leaves of rabdosia rosthornii (diels) hara (labiatae) were tested. they exhibited antibacterial activity specifically against gram-positive bacteria, among which propionibacterium acnes was noted to be the most susceptible. | 2004 | 15022175 |
| proinflammatory cytokine production by human keratinocytes stimulated with propionibacterium acnes and p. acnes groel. | keratinocytes form the first line of defence in the skin and alert the host to danger by the production of a number of cytokines and chemokines. however, the interaction of commensal microorganisms with keratinocytes has not been well studied. | 2004 | 15030323 |
| evaluation of the antibacterial efficacy of diesters of azelaic acid. | a number of diesters of the topical dermatosis treatment azelaic (nonanedioic) acid were prepared and tested for antibacterial effect. two esters, bis-[(hexanoyloxy)methyl] nonanedioate and especially bis-[(butanoyloxy)methyl] nonanedioate showed promising activity against acne related bacteria in vitro. no activity of azelaic acid was detected in mueller hinton ii agar at ph 7.3 when using the agar diffusion method, whereas both esters gave zones of growth inhibition. at ph 5.6, activity of aze ... | 2004 | 15066659 |
| pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of propionibacterium acnes. | etiology of sarcoidosis remains unknown. a trigger factor from propionibacterium acnes causes a cellular immune response in some sarcoid patients but not in nonsarcoid subjects. we examined whether experimentally induced hypersensitivity to the trigger factor gives rise to granulomas. female c57bl/6 mice primed intravenously with p. acnes or not were sensitized with recombinant-protein rp35, a fragment of p. acnes trigger factor, and complete freund's adjuvant. in controls, rp35 was replaced wit ... | 2003 | 15074354 |
| topical retinoid and antibiotic combination therapy for acne management. | the agents most commonly used in combination for the management of acne include topical retinoids and antibiotics. topical retinoids normalize desquamation of the follicular epithelium, whereas antibiotics inhibit the growth of p. acnes and the production of free fatty acids. this therapeutic combination decreases comedogenesis, bacterial growth, and inflammation, thus targeting three of the four pathogenic factors associated with acne. efficacy and tolerance are maximized with combination thera ... | 2004 | 15098969 |
| purification and characterisation of lipoglycan macroamphiphiles from propionibacterium acnes. | lipidated macroamphiphiles such as the lipoteichoic acids and mycobacterial lipoarabinomannans are cell envelope components of gram-positive bacteria that have been extensively associated with the pathogenesis of disease. in order to study such associations, purification of these macroamphiphiles is essential for resolving their structures and diverse biological effects. we describe herein a method for purification of lipoglycan components from propionibacterium acnes. this method uses the exist ... | 2004 | 15103239 |
| topical antibacterial treatments for acne vulgaris : comparative review and guide to selection. | topical antibacterial agents are an essential part of the armamentarium for treating acne vulgaris. they are indicated for mild-to-moderate acne, and are a useful alternative for patients who cannot take systemic antibacterials. topical antibacterials such as clindamycin, erythromycin, and tetracycline are bacteriostatic for propionibacterium acnes, and have also been demonstrated to have anti-inflammatory activities through inhibition of lipase production by p. acnes, as well as inhibition of l ... | 2004 | 15109272 |
| characterization of thoeniicin 447, a bacteriocin isolated from propionibacterium thoenii strain 447. | fifteen strains of propionibacteria, isolated from dairy products, were screened for the production of bacteriocins. propionibacterium thoenii 447 produced an antimicrobial peptide, thoeniicin 447, which acted bactericidal against lactobacillus delbrueckii subsp. bulgaricus and bacteriostatic against propionibacterium acnes. thoeniicin 447 remained active after 15 min at 100 degrees c and after 30 min of incubation at ph 1-10. the peptide was inactivated when treated with pepsin, pronase, alpha- ... | 2004 | 15109792 |
| shunt nephritis with positive titers for anca specific for proteinase 3. | the authors report a case of shunt nephritis with antineutrophil cytoplasmic autoantibody (anca) and review 2 similar cases. a 55-year-old man was admitted to our hospital for continuous fever and foot edema in 2002. a ventriculoperitoneal shunt was implanted because of a brain abscess and subsequent hydrocephalus in 1987; it was changed to a ventriculoatrial (va) shunt in 1995. urinary analysis showed proteinuria (5.4 g/d) and microscopic hematuria. laboratory data showed renal dysfunction and ... | 2004 | 15112193 |
| late-onset central nervous system shunt infections with propionibacterium acnes: diagnosis and management. | 2004 | 15118785 | |
| propionibacterium acnes biotypes and susceptibility to minocycline and keigai-rengyo-to. | propionibacterium acnes is the predominant organism in acne lesions, but the sensitivity of different biotypes of p. acnes to therapeutic agents has seldom been reported. | 2004 | 15125499 |