Publications

[recurrent thromboembolism disclosing protein c deficiency. apropos of a case with familial investigation].	every thromboembolic manifestation, especially in young subjects, calls for an aetiological study in which haemostasis is evaluated primarily with assays of physiological coagulation inhibitors: protein c, protein s and antithrombin iii. protein c deficiency is found in 6 to 7% of thromboembolic manifestations. we report the case of a 21-year old man who had phlebitis followed by pulmonary embolism without facilitating factors. protein c level was 50% of normal value (0.50 iu/ml). the patient re ...	1990	2075365
[shigellosis].		1990	2076763
reoperation for moyamoya disease refractory to encephalo-duro-arterio-synangiosis.	three cases of moyamoya disease successfully treated by reoperation are reported with special reference to the operative techniques in the second operation. these children first underwent encephalo-duro-arterio-synangiosis (edas). because two of the three postoperative collateral formations through edas were either poor or not present at all and their symptoms remained. encephalo-myo-synangiosis (ems) was later added in the posterior frontal and/or parietal regions of the same side as the former ...	2006	2077849
[the indices of pancreatic incretory function in acute intestinal infections].	results are reported of a study of the incretory function in 156 patients with acute intestinal infections. the incretory pancreatic function was found to be deranged in most patients in the acute period and tended to slow restoration during convalescence. this indicates the necessity of perfecting pathogenetic treatment of these patients and clinico-laboratory follow-up of patients with a history of acute intestinal infection with consideration of the incretory pancreatic function.	1990	2080556
[a case of paroxysmal ventricular tachycardia surgically treated based on electrophysiological diagnosis].	there was presented a case of recurrent ventricular tachycardia in the patient after myocardial infarction. considering uneffective pharmacotherapy and several cardiac arrests, the patient underwent guided endo-cardiotomy based on complex electrophysiological diagnostics (including intraoperative examination). postoperative period was uncomplicated. there were no recurrences of ventricular tachycardia during 18-month follow-up.	2007	2082073
cognitive behavioural couples therapy with gay men referred for counselling in an aids setting: a pilot study.	counselling and psychological therapy is now an established part of health care in most aids settings, yet intervention has thus far tended to focus on the individual. it is argued that there is a need for greater development of therapy for couples in the aids field, based on the results of a pilot study of cognitive-behavioural couples therapy with 10 couples referred to a clinical psychologist working in an aids setting. results suggest that satisfaction with the relationship significantly imp ...	2007	2083260
[clinico-morphological comparisons in different types of dysentery].	clinical evidence and morphological picture of rectal biopsy specimens were analysed for 125 dysentery patients. as compared to a light course, moderately severe and severe dysentery presented enhanced microbial adherence and an elevated level of large lymphocytes in the external epithelium of the rectum, deeper penetration of shigella into crypts. on day 9-15 of the disease in attenuation of the clinical symptoms in severe and moderately dysentery morphological shifts persisted whereas the ligh ...	1990	2084341
specific binding of virg to the vir box requires a c-terminal domain and exhibits a minimum concentration threshold.	the positive regulatory protein virg from the virulence region of the ti plasmid of agrobacterium tumefaciens was first demonstrated to possess dna-binding capabilities using chromatographically purified protein and in vitro assays (powell et al., 1989). this paper is an extension of that research and presents evidence on the in vivo dna-binding properties of virg using a transcription interference assay. virg protein bound specifically to a 'vir box' response element and repressed transcription ...	1990	2089226
[ktk and tco-s are disappearing--shstf will negotiate alone].		2007	2094087
intraradicular bacteria and fungi in root-filled, asymptomatic human teeth with therapy-resistant periapical lesions: a long-term light and electron microscopic follow-up study.	light and electron microscopy were used to analyze nine therapy-resistant and asymptomatic human periapical lesions, which were removed as block biopsies during surgical treatment of the affected teeth. the cases that required surgery represented about 10% of all of the cases which received endodontic treatment and root fillings during the period 1977 to 1984. these cases revealed periapical lesions when they were examined 4 to 10 yr after treatment. the biopsies were processed for correlated li ...	1990	2094761
[the clinico-pathogenetic significance of disorders of the immune status in dysentery].	as many as 256 patients with flexner's dysentery caused by the same source of infection were examined. it has been established that in patients with a severe and protracted course of the disease, secondary immunodeficiency is formed by the relative hypersuppressor type and the function of phagocytizing macrophages decreases. patients with the reduced immune characteristics manifest deceleration of convalescence and repeated isolation of shigella after the antibiotic therapy. it is concluded that ...	1990	2094988
[health economics--stopgap measures are no decisions. interview by kaj nyman].		2006	2095080
ultrastructural features of microbial colony organization.	the ultrastructure of microbial colonies was studied. inside the colonies three types of intercellular contacts were demonstrated. in the colonies of gram-negative bacteria, the cells were found to be connected by tight adhesions of outer membranes of the cell walls and membrane bridges. in the colonies of gram-positive bacteria, the intercellular contacts were formed by fusion of peptidoglucan layers of the cell walls. bacterial cells were differentiated by the presence of a capsule-like envelo ...	1990	2097346
potential shigella flexneri 2a and shigella sonnei i live vaccinal strains. characterization of immunogenicity in animal models.	rats and rabbits were immunized intraintestinally with different doses of virulent and nonvirulent live shigella flexneri 2a and shigella sonnei i strains. the nonvirulent strains had one or two attenuating markers. the period of excretion with the faeces of the bacteria and of their polysaccharide antigens, the proliferation of antigen-binding and antibody-producing cells in the spleens and gut-associated lymphoid tissues and the levels of antibodies in sera and faeces were studied. attenuated ...	1990	2099082
[bruxism. n.m.r.s].		2007	2099471
construction and evaluation of live attenuated vaccine strains of shigella flexneri and shigella dysenteriae 1.	shigellosis is an invasive disease of the human colon which is particularly prevalent among children of the developing world. no proper vaccine is available to protect against this enteric disease. it is currently accepted that only live strains with attenuated virulence administered orally may elicit protective immunity at the level of the colonic mucosa, which is the exclusive site of multiplication of causative microorganisms such as shigella flexneri and shigella dysenteriae 1. we have const ...	1990	2101481
hybrid vaccines using escherichia coli as an antigen carrier.		1990	2101482
[experience in using new drug preparations for treating adult patients with acute intestinal infections].	ciprofloxacin (bayer, frg), a derivative of hydroxyquinolone acid, was used for the treatment of patients with shigellosis and salmonellosis and for the sanitation of salmonella carriers. the drug turned out to exert a positive effect on bacteriological sanitation of the body. in order to treat patients with food toxinfection of unknown etiology, use was made of intetrix (farmacos, socialist federal republic of yugoslavia). inclusion of the drug into combined treatment of patients with food toxi ...	1990	2110389
molecular characterization of promoters of the lactococcus lactis subsp. cremoris temperate bacteriophage bk5-t and identification of a phage gene implicated in the regulation of promoter activity.	dna fragments from the temperate lactococcal bacteriophage bk5-t were cloned into the promoter-detecting plasmid pmu1328. five dna fragments conferring promoter activity were selected by transformation of streptococcus sanguis and were functional in escherichia coli, s. sanguis, and lactococcus lactis subspp. lactis and cremoris. the nucleotide sequences of these fragments were determined, and primer extension analysis was used to locate the site of initiation of transcription from each promoter ...	1990	2111118
electrolyte abnormalities associated with diarrhea in rhesus monkeys: 100 cases (1986-1987).	serum electrolyte values from 100 rhesus monkeys with diarrhea were reviewed. the most frequent finding was hyponatremia (88%), with hypochloremia next most frequently detected (80%). metabolic acidosis was less common (59%) and usually associated with high anion gap values. associations between electrolyte abnormalities and age, housing, or case outcome were not found. bacteriologic culturing was performed on fecal specimens from 90 monkeys. campylobacter coli or c jejuni alone was isolated fro ...	1990	2112122
imaging of chronic renal infections.		2007	2117344
effects of propofol on cerebral hemodynamics and metabolism in patients with brain trauma.	the authors determined the effect of propofol on cerebral blood flow, intracranial pressure, and cerebral arteriovenous oxygen content difference in severely brain-injured patients during orthopedic treatment of fractures of the extremities. the glasgow coma scale score was 6 or 7 at the time of the study. data were collected in the operating room before and during (5 and 15 min) administration of propofol (2 mg/kg iv bolus immediately followed by a 150 micrograms.kg-1.min-1 infusion) before sur ...	2006	2118315
phorbol myristate acetate inhibits hela 229 invasion by bordetella pertussis and other invasive bacterial pathogens.	the microfilament inhibitors cytochalasins b and d have been traditionally used to indirectly evaluate the requirement for actin in the uptake of invasive bacterial pathogens by nonprofessional phagocytes. through their effects on microfilaments, both cytochalasins also impart profound alterations in cellular morphology and surface topology, which likely interfere with adherence. alterations affecting adherence would complicate interpretation of the effect of cytochalasins on entry alone. as an ...	1990	2119340
[acute severe dyspnea as a side effect of drugs. report from the chdm (comprehensive hospital drug monitoring)].	this "syndrome" has been observed in 4 of 23,935 in-patients registered in the years 1974-1987 in the comprehensive hospital drug monitoring (bern/st. gallen), with 6 reactions. signs of an attack of bronchial asthma, laryngeal or pulmonary edema or a (heart-)circulatory event were not observed. each patient was cyanotic and 3 had the feeling of impending death. the eliciting drugs were penicillin-g (twice) and cefazolin (once), given i.v.; iron dextran i.m. (once); pitressin tannate i.m. (once) ...	1990	2120771
the two-component regulatory system ompr-envz controls the virulence of shigella flexneri.	in shigella flexneri, the ompb locus (containing the ompr and envz genes) was found to modulate expression of the vir genes, which are responsible for invasion of epithelial cells. vir gene expression was markedly enhanced under conditions of high osmolarity (300 mosm), similar to that encountered in tissues both extra- and intracellularly. two ompb mutants were constructed and tested for virulence and for osmotic regulation of vir genes. an envz::tn10 mutant remained invasive, although its viru ...	1990	2121709
growth inhibition of selected food-borne bacteria, particularly listeria monocytogenes, by plant extracts.	six extracts from chinese medicinal plants: tin men chu, sey lau pai, siu mao heung, bak tao yung, kam chin chiu and liao ya, were tested for their inhibitory effect on selected food-borne bacteria by the well assay technique. among them, tin men chu, siu mao heung and sey lau pai inhibited the growth of staphylococcus aureus, klebsiella pneumonia, escherichia coli, shigella flexneri, streptococcus faecalis, salmonella paratyphi, salm. enteritidis, enterobacter aerogenes, pseudomonas fluorescens ...	1990	2127264
[advances in fibrinolysis mediated by vascular endothelial cells].		1984	2129251
cloning, sequencing and chromosomal assignment of a gene from saccharomyces cerevisiae which is negatively regulated by glucose and positively by lipids.	we report the molecular cloning, nucleotide (nt) sequence and chromosomal assignment of the saccharomyces cerevisiae gene glp1. this gene encoded a 15-kda protein that was synthesized at a low level during growth on glucose and was induced ninefold upon glucose deprivation. when glucose withdrawal was accompanied by the addition of fatty acids the induction was enhanced an additional two- to threefold. the glp1 gene product was identified as a soluble protein and purified using a combination of ...	1990	2129531
studies on nonspecific protection induced with omp of shigella flexneri and other genera of enterobacteriaceae.	outer membrane proteins (omp) isolated from shigella flexneri, escherichia coli, proteus vulgaris and salmonella typhimurium were tested for their protective activity. each omp preparate given to mice intraperitoneally in a single injection (5 micrograms/per mouse) protected the animals not only in homologous but also in varying intensity in heterologous systems. evidence was obtained that this nonspecific protection is cell mediated.	1990	2130800
immunogenic and protective properties of outer membrane proteins of hafnia alvei.	outer membrane proteins (omp) extracted from antigenically distinct or related strains of hafnia alvei containing defined composition of major proteins proved to be immunogenic. intraperitoneal immunization of mice with a single dose of such preparations protected the animals against homologous and heterologous hafnia strains. the omp preparations were also found to induce protection with varying intensity against escherichia, proteus, shigella and salmonella.	1990	2130804
in vivo protein metabolism utilizing stable isotopes and mass spectrometry: a new approach to the study of mutant proteins in humans.		1997	2132530
a genetic therapy for familial hypercholesterolemia.	the whhl rabbit serves as an animal model for the human genetic disease, familial hypercholesterolemia. in initial studies aimed at the development of a genetic therapy for familial hypercholesterolemia (i.e., introduction of a normal ldl receptor gene), whhl rabbit skin fibroblasts were transduced with a retroviral vector expressing a normal human ldl receptor. correction of the whhl rabbit genetic defect in vitro was confirmed. autologous fibroblasts expressing ldl receptors were reimplanted i ...	1990	2132544
toxicity of certain pesticides against the chicken mite, dermanyssus gallinae.		1990	2132965
acute severe jaundice in a young patient.		1999	2133196
[preparation of microbial silage from fish of underutilized species].	fish silage was produced by microbial means from a mixture of several fish species which are not used for human consumption, and form part of the shrimp by-catch. the fish was mixed with a carbohydrate source (molasses) and a starter culture of lactobacillus plantarum 8014. the mixture was fermented at 30 +/- 2 degrees c. several tests were undertaken to determine the optimal conditions and concentration of molasses (5, 10 and 15%) and lactobacillus (0.5, 1.0, 2.5, 5.0 and 10.0%). results indica ...	1990	2134144
nucleotide sequence of the salmonella typhimurium glya gene.	the dna sequence of the salmonella typhimurium glya gene has been determined. the polypeptide deduced from the dna sequence contains 417 amino acids and has a calculated molecular weight of 45428 daltons. s1 nuclease mapping experiments located the transcription start point and possible transcription termination region. the nucleotide and amino acid sequences for the s. typhimurium and escherichia coli glya genes were compared. the nucleotide sequences show 89% identity, and the amino acid seque ...	1990	2134182
a biotechnology view of glycobiology.		1954	2136377
affects and cognitions of mothers and fathers of preterm infants.	this descriptive study examined the feelings and thoughts of mothers and fathers of preterm infants. responses were solicited while the infant was in a special care nursery as well as in the home. mothers and fathers responses between the hospital and the home setting were compared as were maternal and paternal responses. general systems theory was the conceptual orientation of this study. this framework provided a perspective on the generation and analysis of affective and cognitive responses o ...	1956	2136576
the cook-chill crisis.		1956	2136614
increased serum levels of lipoprotein(a) in diabetes mellitus and their reduction with glycemic control.		1957	2136711
the premorbid personality of patients with different subtypes of an affective illness. statistical analysis of blind assignment of case history data to clinical diagnoses.	on the basis of case history data, the assumption that there exists an association between the 'manic type' of personality and a predominantly manic course of an affective illness, and between the 'melancholic type' of personality and a unipolar depressive course of the illness was examined. premorbid data were extracted from 42 case records, 10 of 'unipolar' manic subjects (the ratio of manic to depressive episodes greater than or equal to 4:1), 11 of typical bipolar i patients, 11 of bipolar i ...	1958	2136868
t cell activation. ii. activation of human t lymphoma cells by cross-linking of their mhc class i antigens.	the present work demonstrates that antibody-induced cross-linking of mhc class i antigens on jurkat t lymphoma cells leads to a rise in intracellular calcium (cai2+) and, in the presence of phorbol ester (pma), to il-2 production and il-2 receptor expression. the rise in cai2+ exhibited a profile very different from that obtained after anti-cd3 antibody-induced activation suggesting that activation signals are transduced differently after binding of anti-cd3 antibody and class i cross-linking, r ...	1990	2137376
regression of left ventricular hypertrophy in dialysis patients following correction of anemia with recombinant human erythropoietin.	left ventricular hypertrophy is an independent determinant of survival in patients with end-stage renal disease, and anemia is one determinant of hypertrophy in such patients. accordingly, the authors studied 22 dialysis patients by echocardiography before and after correction of their anemia with recombinant human erythropoietin. observers were blinded to patient identity and order of studies. hemoglobin increased from 63 +/- 8 g/l (mean +/- standard deviation) to 114 +/- 15 g/l; an increase of ...	1990	2138048
induction of pharmacological hypogonadotropism using gonadotropin-releasing hormone agonists in patients undergoing controlled ovarian stimulation.	pharmacological hypogonadotropism was induced in 167 women using the gonadotropin-releasing hormone agonists (gnrh-a) buserelin acetate or triptorelin acetate. 84 patients (group 1) began treatment using 1.2 mg/day buserelin acetate intranasally during the follicular phase (days 1-3); 41 patients (group ii) began the same treatment, supported by 10 mg medroxyprogesterone acetate for 10 days, during the early luteal phase; 42 patients (group 3) received triptorelin acetate as an intramuscular dep ...	1997	2139863
clonal deletion of self-reactive t cells at the early stage of t cell development in thymus of radiation bone marrow chimeras.	sequential appearance of t cell subpopulations occurs in the thymocytes of irradiated c3h/he mice (h-2k, mls-1b2a, thy-1.2) after transplantation with bone marrow cells of akr/j mice (h-2k, mls-1a2b, thy-1.1) (akr----c3h chimeras). the donor-derived thymocytes of akr----c3h chimeras on day 14 after bone marrow transplantation (bmt) contained a large number of blastlike cd4+cd8+ cells which represent relatively immature thymocytes, whereas those on day 21 after bmt consisted of small sized cd4+,c ...	2004	2141619
effects of chronic non-ketotic diabetes and aging on myocardial function and fatty acid oxidation.	the effects of aging and chronic non-ketotic diabetes on contractile properties, oxygen consumption, palmitate oxidation and morphology were studied in isolated, perfused working hearts of 2, 9, 12 and 22 month old rats. the heart rate, coronary flow, and oxygen consumption were no different among the 9, 12 and 22 month control and diabetic hearts. cardiac work was not depressed in control hearts until 22 months of age. depression of cardiac output due to aging in the control hearts progressed i ...	1990	2141842
[antibiotic resistance of shigella isolated in the kara-kalpak a.s.s.r. 1987-1988].	sensitivity of shigella spp. isolated in one of the hospitals of nukus within 1987-1988 and earlier in 1977 and 1985 was studied. s. flexneri 1-5 remained the main causative agents of dysentery on the territory. however, beginning from 1987 there were registered cases of dysentery caused by s. dysenteriae 1. the isolates were most sensitive to cefotaxime, cephaloridine, polymyxin b and gentamicin. the majority of the isolates were resistant to tetracycline, levomycetin (chloramphenicol) and stre ...	1990	2144726
[effects of hypertrophy on cardiac systolic and diastolic performance in athletes with mild hypertension].	aims of the study has been the evaluation of morphological and functional aspects of left ventricle in subjects undergoing mild hypertension and sport adaptation effects. these evaluations have been carried out by echo-doppler both at rest and during sharp increase in after load induced by isometric stress. together with the morphological parameters represented by mass index and by radius to thickness ratio, we have studied stroke volume and transmitral flow pattern assessing the maximum flow ve ...	2000	2150692
[the role of tuberculin test and fluoroscopy in detecting intra- thoracic tuberculosis in children and adolescents living in the rural area with high incidence of tuberculosis].	the analysis of 91 case records of children and adolescents living in rural area with a high incidence of tuberculosis was made. these patients were detected through screening and by means of tuberculin diagnosis and fluorography carried out by a team of health workers on a case-finding mission. the organization of work with due regard for the local conditions makes it possible to use the above methods for an early detection of the given disease; to assess the results obtained from the very begi ...	2000	2150699
the aids figures.		2001	2150732
electrolyte and water transport in the newt renal tubule due to the action of low-molecular fractions isolated from the intestine of the hibernating ground squirrel.	the micropuncture technique and x-ray microanalyses were used to evaluate na, k, ca, mg, cl and fluid transport in the early distal tubule mediated by low-molecular fractions isolated from the intestine of the hibernating ground squirrel (hsi). perfusion of intertubular capillaries with a solution containing hsi with a molecular weight of 1-10 kd (0.1 mg.ml-1) decreased the relative reabsorption of fluid, ca and mg. the other low-molecular fraction 1-10 kd of m.v. (0.1 mg.ml-1) isolated from the ...	2007	2150987
tissue and subcellular distribution of endonexin, a calcium-dependent phospholipid-binding protein.		2008	2151035
[automated information system as a method of studying and preventing morbidity among workers in the petroleum industry].		1999	2151192
[a case of group morbidity from reiter's syndrome in patients with a history of acute intestinal infection].		1990	2151299
inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases.	metalloproteinases secreted by tumor cells play an important role in metastasis. in the present study, we determined whether an inhibitor of these proteinases could inhibit the ability of tumor cells to degrade collagen and to metastasize. metalloproteinases with degradative activities for type i collagen, type iv collagen, gelatin, and casein were secreted by a highly metastatic rat embryo cell line (4r) transfected by c-ha-ras1 (also known as hras1). these metalloproteinases were identified by ...	1990	2156082
simultaneous primary infection with hiv and cmv leading to severe pancytopenia, hepatitis, nephritis, perimyocarditis, myositis, and alopecia totalis.	simultaneous primary infection with hiv and cmv in an 18-year-old woman led to an acute cytotoxic reaction, manifesting as pancytopenia, hepatitis, nephritis, perimyocarditis, and myositis. within 14 days parameters indicating acute cell damage reverted to normal. two weeks later transient alopecia totalis developed. initially, hiv-antigen but no hiv antibodies were present. within 3 weeks hiv-igg antibodies appeared while hiv antigen disappeared. anti-cmv-igm was clearly and anti-cmv-igg questi ...	1990	2156107
enhancement of the proliferation of murine fetal liver erythroid progenitors by infection with harvey sarcoma virus.	we recently developed a new progenitor assay using murine fetal liver cells that provides a source of pluripotent progenitors, bipotent progenitors, and committed macrophage, megakaryocyte, erythroid, and mast cell progenitors. this clonal cell culture system was used to examine the direct effects of harvey sarcoma virus on murine hemopoietic progenitors. very large erythroid colonies containing 100,000 to 200,000 cells were seen in the infected group. only small erythroid colonies were seen in ...	1999	2156115
mri quantitation of edema in focal cerebral ischemia in cats: correlation with cytochrome aa3 oxidation state.	1h mri permits detection of edema in the brain. in a middle cerebral artery stroke model in the cat, we found a significant correlation between an edema index based on mri and a sensitive metabolic index of ischemia, the in vivo oxidation status of mitochondrial cytochrome aa3 determined by near-infrared reflectance spectrophotometry (r = -0.70, alpha = 0.001). this result suggests that a simple, noninvasive study using mri can provide an index of the extent of ischemic damage in an experimental ...	1990	2156126
molecular characterization of a trans-acting, positive effector (ipar) of invasion plasmid antigen synthesis in shigella flexneri serotype 5.	a trans-acting, positive effector of invasion plasmid antigen (ipa) synthesis has been identified and mapped on the pwr100 invasion plasmid of shigella flexneri serotype 5 (strain m90t-w). recombinant plasmids carrying this regulatory gene, designated ipar, were found to restore full virulence to a non-invasive ipar::tn5 insertion mutant [m90t-w(phs1042)] that had lost the ability to synthesize four ipa antigens (ipaa, 70 kda; ipab, 62 kda; ipac, 42 kda; and ipad, 37 kda). genetic mapping of the ...	1990	2166210
coxsackie b1 virus infection enhances the bacterial invasiveness, the phagocytosis and the membrane permeability in hep-2 cells.	to analyze the effect of coxsackie b1 virus infection on bacterial invasiveness, phagocytosis and cytoplasma membrane permeability, we have studied invasiveness of shigella flexneri, unspecific phagocytosis of latex particles and release of the non-metabolizible amino acid, alpha-aminoisobutyric acid (aib). virus infection enhanced invasiveness of s. flexneri and phagocytosis of latex beads and increased plasma membrane permeability as measured by release of aib. the effect on all three function ...	1990	2166540
morphine and fentanyl anesthetic interactions with diazepam: relative antagonism in rats.	the anesthetic effects of morphine-diazepam and fentanyl-diazepam combinations as characterized by abolition of the movement response to noxious stimulation were studied in rats to test the hypothesis of antagonistic interactions between the components of these combinations. noxious pressure on the tail was used to induce the response. dose-effect curves were constructed for the drugs given alone and in combination. with the use of probit procedure ed50 values for single drugs and their combinat ...	1990	2168134
kinetics of the reaction of prostaglandin h synthase compound ii with ascorbic acid.	the reduction of prostaglandin h synthase compound ii by ascorbic acid in the presence of diethyldithiocarbamate was studied in 0.1 m phosphate buffer (ph 8.0) at 4.0 +/- 0.5 degrees c, by rapid scan spectrometry and transient state kinetics. a saturation effect and nonzero intercept were observed in the plot of pseudo-first-order rate constant versus ascorbic acid concentration. the saturation behavior suggests formation of a complex between prostaglandin h synthase compound ii and ascorbic aci ...	1990	2168160
the effect of naloxone on lipid-induced pyloric motor response in humans.	this study examines whether opioid receptors are involved in the mediation of the pyloric motor response to intraduodenal lipid infusion. antral, pyloric, and duodenal manometry was performed in seven healthy volunteers with a sleeve/multiple side-hole manometric assembly. triglyceride emulsion and normal saline were infused alternately into the duodenum through the manometric assembly for two 30-minute periods each. naloxone was then administered as an iv bolus, 40 micrograms/kg, followed by an ...	2007	2168331
anti-viral immunity induced by recombinant nucleoprotein of influenza a virus. iii. delivery of recombinant nucleoprotein to the immune system using attenuated salmonella typhimurium as a live carrier.	a plasmid encoding the influenza nucleoprotein gene from a/nt/60/68 virus was transduced into the attenuated salmonella typhimurium aroa- strain sl3261. the bacterial vector expressing the viral gene product was able to induce both humoral and cell-mediated immune responses to the nucleoprotein antigen. cd4+ virus-specific t cells capable of proliferation were readily induced and, in some circumstances, class ii major histocompatibility complex (mhc)-restricted cytotoxicity was detected. however ...	1990	2168340
rapid detection of herpes simplex virus in clinical samples by flow cytometry after amplification in tissue culture.	murine monoclonal antibodies (mabs) against herpes simplex virus type 1 and 2 (hsv-1 and -2, respectively) nuclear antigens were used to identify cells infected with hsv-1 or -2 by indirect immunofluorescence in conjunction with flow cytometry after virus amplification of mrc-5 cell monolayers. the results indicate that mabs q1, q2, and h-640 detect hsv-1- and hsv-2-infected cells, mab sd-1 detects hsv-2- but not hsv-1-infected cells, and mab 58-s detects hsv-1- but not hsv-2-infected cells. mab ...	1990	2168440
bibliography of the current world literature in hypertension.		2007	2168447
[collagen adhesion-aggregation abnormality (2nd report)--congenital platelet membrane glycoprotein vi deficiency].	previously, we reported a case of 26-year-old woman with a mild bleeding tendency whose platelets specifically lacked collagen-induced aggregation and adhesion to collagen fibrils. in this report, we investigated the membrane glycoproteins of this patient's platelets and found that her platelets were absent in a 61-kda glycoprotein, which was identified to be glycoprotein vi (gp vi) of the platelet membrane. her parents platelets contained about 50% the normal amount of gp vi. these results indi ...	2007	2168494
modulation of experimentally induced epilepsy by intracerebral grafts of fetal gabaergic neurons.	systemic administration of pilocarpine to rats induces seizures that resemble complex partial epilepsy in humans. susceptibility to these seizures is increased by lesion of the gabaergic striatonigral projection. transplantation of fetal gabaergic neurons, but also of control non-gabaergic tissue, to the deafferent substantia nigra can reduce such lesion-increased seizure susceptibility. these observations are consistent with prior evidence that gabaergic basal ganglia outflow plays an important ...	1990	2168529
[a method for the formalized assessment of neurotic manifestations].	a method of estimation of the level of neurotization and psychopathization modified and tried by the author is described. four scales are distinguished: asthenias, depressions, anxieties and hypochondrias. based on a statistical evaluation of the results of examining 152 patients with neurasthenia and 82 normal persons criteria for differentiating between the clinical and subclinical levels of neurotization have been derived.	2007	2168636
[brain stem auditory evoked potentials in the early period after a brain concussion].	acoustic truncal evoked potentials (atep) were studied in 24 patients in the first 48 hours after concussion of the brain. the absolute peak latency of components 1, 3, and 5, the interpeak intervals 1-3, 3-5, and 1-5, and the interaural difference were determined. the results were compared with those of examination of a control group of 24 healthy individuals. individual and group appraisal failed to reveal any significant differences from normal values in none of the studied parameters in pati ...	2007	2168645
[the diagnosis and method of surgical treatment in dislocation of the brain under the falx cerebri in craniocerebral trauma].	in 6.6% of cases a severe craniocerebral trauma is accompanied with dislocation of the brain under the falx cerebri with incarceration of the cingulate gyrus. the diagnosis of dislocation under the falx in intracranial traumatic hematoma and brain contusion-crushing is discussed. falxotomy may be among the methods for the prevention or correction of incarceration of the cingulate gyrus. the authors suggest an operative approach for performing falxotomy with little injury as well as a surgical in ...	2007	2168652
molecular mechanisms of glial cell swelling in acidosis.	the mechanism of glial swelling in acidosis were investigated in an in vitro model. c6 glial cells were exposed to ph levels between 7.4 and 6.2. the cell volume response was determined by flow cytometry. cell swelling of 110% to 115% was observed if ph was reduced to 6.8 or below. this effect was independent of the length of exposure to acidosis. swelling induced by ph could be attenuated by (a) inhibition of the na+/h+ antiporter by amiloride, (b) replacement of bicarbonate by hepes, and (c) i ...	1990	2168665
antiinflammatory properties of the new antirheumatic agent 4-acetylaminophenylacetic acid.	the antiinflammatory activity of 4-acetylaminophenylacetic acid (ms-932) was investigated. ms-932 did not suppress the acute inflammation of carrageenin-induced paw edema in rats or of primary swelling in adjuvant arthritic rats. however, prophylactic treatment with ms-932 inhibited secondary inflammation in adjuvant arthritic rats. ms-932 also restored to normal the weight of the spleen and the serum albumin/globulin ratio of adjuvant arthritic rats. in addition to its prophylactic effect, ms-9 ...	1990	2168705
[a case of pulmonary metastasis from adenoid cystic carcinoma of the trachea].	a 33-year-old woman with adenoid cystic carcinoma of the trachea was treated by resection of the upper and mid-trachea, plus total laryngectomy, subtotal thyroidectomy, partial resection of the cervical esophageal muscle layer and mediastinal tracheostomy. this tumor invaded directly into the thyroid gland, the larynx, the recurrent laryngeal nerve and the cervical esophagus. three years after the operation, metastases developed in the right lung (s10, s2) and partial resection of the lung was p ...	2007	2168922
[clinical investigation of hepatectomies for hepatocellular carcinoma--significance of extended hepatectomy for advanced hepatocellular carcinoma].	although the diagnostic methods for hepatocellular carcinoma (hcc) are now being improved, there are still many cases detected at advanced stage. we, based on the redox theory and using a technique of vascular surgery and liver transplantation, made it possible to perform the extended hepatectomy more actively even in the advanced cases which were previously considered to be in-operable. we report these extended hepatectomies in this paper. from january 1985 to august 1989, we performed 263 hepa ...	2007	2168926
photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse.	albino hairless mice (skh:hr-1) exposed chronically to suberythemal doses of ultraviolet radiation develop visible skin changes, histological alterations, and tumors. topical treatment of mice with solutions of superoxide-scavenging antioxidants (such as alpha-tocopherol, ascorbic acid, propyl gallate and trolox) prior to each uvb radiation exposure reduced significantly the severity of these events. tocopherol esters and ascorbyl palmitate were not as effective as the parent compounds in provid ...	1990	2169296
preliminary doppler studies on the uterine artery and myometrium in trophoblastic tumours requiring chemotherapy.	the uterine circulation in 38 patients with invasive mole or choriocarcinoma were investigated using doppler ultrasound. twenty-six non-pregnant and 23 pregnant volunteers were assessed in a similar fashion to act as control groups. the pulsatility indices were significantly lower in the patients with trophoblastic disease when compared with the non-pregnant and pregnant groups (student's t-test; p less than 0.001 and p less than 0.02 respectively). the uterine circulation in persistent trophobl ...	2008	2169301
effects of blood glucose concentration on thermogenesis and glucose disposal during hyperinsulinaemia.	1. the thermogenic and cardiovascular responses to glucose ingestion or infusion are altered by undernutrition. these changes may be due, in part, to alterations in the blood glucose concentration. this study investigates the effect of variation in the blood glucose concentration on the thermogenic and cardiovascular responses to a hyperinsulinaemic glucose clamp. 2. ten healthy post-absorptive subjects (six male, aged 21-30 years) were studied on two occasions. baseline measurements were made f ...	2000	2169378
inactivation of beta-lactamase from shigella flexneri ucsf-129 by 6-beta-iodopenicillanic acid: classification of the enzyme.	the beta-lactamase from shigella flexneri ucsf-129 was irreversible inactivated by 6-beta-iodopenicillanic acid. only one serine residue was modified, according to the spectra change and the amino acid analyses. a ph variation of 0.3 units was found when the chemically modified enzyme was submitted to isoelectric focusing. the inactivation constant of the fast time course reaction was 0.1 seg-1. protection of 96% was obtained, using cephradine 2,830 times more concentrated than 6-beta-iodopenici ...	1990	2170824
prevalence of human papillomaviruses in cervical scrapings of unselected women.		1990	2171941
a nonvirulent mutant of listeria monocytogenes does not move intracellularly but still induces polymerization of actin.	listeria monocytogenes has the capacity to penetrate and multiply within professional and nonprofessional phagocytic cells, such as the caco-2 human enterocytelike cell line. it was shown recently that shortly after listeriae have been phagocytosed, the phagosomal membrane is dissolved, probably by the action of the bacterial cytolysin listeriolysin o. the listeriae, which are then lying obviously free in the cytoplasm, become surrounded by a coat of actin filaments within a few hours. once form ...	1990	2172164
quantitative study of the structure-stability relationship of tcvo(iii) complexes.	this paper describes the quantitative structure-stability relationship of tcvon2s2 compounds using a stability indicator based on the solid angle factor sum (sas) for predicting the in vitro stability. the sas values of six tcvon2s2 and one tcvon4 (d,l-hmpao) complexes were calculated from their x-ray crystallography data. the rank order of in vitro stability of these compounds, as measured by ligand exchange reaction, is directly related to that of the sas values. the sas values are potentially ...	2004	2172189
expression of major histocompatibility complex antigens on inflammatory peripheral nerve lesions.	the expression of major histocompatibility complex (mhc) antigens by cells of the rat peripheral nervous system (pns) was studied using a model of peripheral nerve transplantation. monoclonal antibodies to polymorphic determinants of mhc class i and class ii (ia) molecules were used to determine donor or recipient origin of mhc antigen-bearing cells in nerve allografts. the expression of class i and class ii antigens by pns parenchymal cells was modified during varying alloimmune conditions. bas ...	1990	2172305
sources of compilations of rate constants for oxygen radicals in solution.		2003	2172698
biphasic effects of polarizing current on adenosine-sensitive generation of cyclic amp in rat cerebral cortex.	cyclic amp accumulation elicited by adenosine was investigated in cortical slices of rats following the application of a weak anodal direct current (anodal polarization) to the unilateral sensorimotor cortex. anodal polarization with 3.0 microa for 30 min caused an increase in the adenosine-elicited accumulation of cyclic amp in the polarized cortex, in which case the increase in the polarized cortical region was highlighted by repeated applications of the currents. polarization with 0.3 microa ...	1990	2173816
[prevalence study on dementia and alzheimer disease].	an epidemiological survey on dementia and alzheimer disease (ad) was carried out in a community of 5055 persons over the age of 55 at jingan district of shanghai. diagnoses were made according to the diagnostic criteria of dementia of dsm-iii-r and of ad of nincds-adrda. it was found that dementia is not uncommon in the aged, and ad was the leading category of dementia. the age and sex adjusted prevalence rate of dementia was 2.57% in those over 55, 3.46% in those over 60, and 4.61% in those ove ...	2000	2174278
[pathogenesis of alzheimer's disease].	the 160 and 200 kd phosphorylated and non-phosphorylated neurofilament monoclonal antibodies were used as the probe to study the cytoskeletal protein distribution inside cerebral neurons of 2 normal adults and 2 patients with alzheimer's disease (ad). immunocytochemical technique was applied in this study. non-phosphorylated neurofilament was located in the perikarua, whereas, the phosphorylated neurofilament was rich in the peripheral of the neuron's cell body and axons in the normal adult brai ...	2000	2174279
human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody.	our previous finding that about 15% of newly diagnosed patients with type 1 (insulin-dependent) diabetes mellitus had human cytomegalovirus genome in their lymphocytes and islet cell autoantibodies in their sera, suggests that autoimmune type 1 diabetes is associated with persistent cytomegalovirus infection under certain circumstances. this investigation was initiated to see if cytomegalovirus can induce islet cell autoantibodies and if the autoantibodies react with any specific islet protein(s ...	1990	2174808
sequencing and enhanced expression of the gene encoding diadenosine 5',5'''-p1, p4-tetraphosphate (ap4a) phosphorylase in saccharomyces cerevisiae.	the gene, dtp, coding for diadenosine 5',5'''-p1, p4-tetraphosphate (ap4a) phosphorylase was isolated from a saccharomyces cerevisiae genomic dna library in lambda gt11. in yeast and escherichia coli transformed with the multicopy vector, yep352, containing the cloned dtp gene, the ap4a phosphorylase was produced at levels nine- to 17-fold higher than in untransformed hosts. the nucleotide (nt) sequence was determined. the gene codes for a polypeptide chain of 321 amino acids (aa). two-aa sequen ...	1990	2174812
local control and lethal toxicity in limited small cell lung cancer.		2000	2174843
superoxide dismutase as a regulatory switch in mammalian testicular steroidogenesis.	the delta 4-pathway of testosterone biosynthesis in leydig cells, widely believed to proceed through pregnenolone--greater than pregnenedione--greater than progesterone route catalyzed by 5 delta-3 beta-hydroxysteroid dehydrogenase and delta 5-delta 4-isomerase respectively is shown to pass through an alternate pathway mediated by superoxide dismutase and peroxidase. a built-in regulatory switch is incorporated in this route, with the superoxide dismutase inducible upon lh-stimulation of the ley ...	2000	2175181
depletion of brain alpha-msh alters prostaglandin and interleukin fever in rats.	alpha-melanocyte stimulating hormone (alpha-msh), a putative endogenous antipyretic agent, is synthesized largely within neurons in the arcuate nucleus. to test the hypothesis that destruction of this area would increase the febrile response, male wistar rats, treated as neonates with intraperitoneal injections of monosodium glutamate (msg) or saline, were given intracerebroventricular (i.c.v.) injections of prostaglandin e1 (20 ng; 200 ng) or purified interleukin-1 (20 u) and body temperature w ...	1990	2175244
[comparative evaluation of clinical and economic effectiveness of preventive therapy of affective and schizoaffective psychoses].	the authors provide the results of a comparative study into the action of different drug approaches to the prevention of relapses of affective and schizoaffective psychoses with the aid of multifactorial consideration of different clinical, economic and socioeconomic indicators characterizing the "benefits and losses" because of the use of carbamazepine and lithium carbonate. the comparative analysis has shown a high normothymic activity of carbamazepine and lithium carbonate in the patients exa ...	2007	2176049
live shigella flexneri 2a and shigella sonnei i vaccine candidate strains with two attenuating markers. i. construction of vaccine candidate strains with retained invasiveness but reduced intracellular multiplication.	live shigella flexneri 2a and shigella sonnei phase i vaccine candidate strains with two virulence-reducing markers were constructed through stepwise incorporation of weakly attenuating purine auxotrophy with subsequent rifampicin-resistance (rna polymerase) mutation to yield optimal attenuation. these vaccine candidate strains showed an unaltered plasmid profile; did not cause keratoconjunctivitis in the sereny test, while being excreted for a short but still marked period and providing partial ...	1990	2180230
live shigella flexneri 2a and shigella sonnei i vaccine candidate strains with two attenuating markers. ii. preliminary results of vaccination of adult volunteers and children aged 2-17 years.	shigella flexneri 2a and shigella sonnei i vaccine candidate strains were tested for tolerance in 14 adults as well as for tolerance and immunogenicity in children aged 2-17 years. for fresh culture material, the limit for side effects fading within 36 h such as meteorism, loose stools, tenesmus and slight temperature, and tolerated by volunteers was 3 x 10(9) colony-forming units (c.f.u.). excretion of vaccine strain germs for 2-3 days was observed only at doses of 10(10) c.f.u. and greater (2- ...	1990	2180231
nucleotide sequence of invasion plasmid antigen gene ipaa from shigella flexneri 5.		1990	2183200
dna supercoiling and environmental regulation of virulence gene expression in shigella flexneri.	bacterial pathogens undergo profound physiological changes when they infect their hosts, requiring coordinated regulation of gene expression in response to the stresses encountered during infection. a number of environmental stresses (such as osmotic shock and anaerobiosis) have been shown to induce changes in dna supercoiling that can directly affect the transcription of a specific subset of bacterial genes, at least some of which (the outer-membrane porins and type 1 fimbriae) play a part in b ...	1990	2184366
a common mechanism of transcriptional activation by the three positive regulators, virg, phob, and ompr.	virg, phob, and ompr are positive regulators of the virulence, phosphate, and osmolarity regulons, respectively. their target genes are attended with one or more significant blocks of similar 6-bp sequences in their regulatory regions. the distance between the block(s) and transcriptional start site varies with the target genes, but the blocks are located in a similar manner phase-specific to the promoter sequences. on the basis of these facts, we offer a novel model of transcriptional activatio ...	1990	2185030
influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney.	it is well established that renin release from the juxtaglomerular epithelioid cells in the media of the afferent arteriole strongly depends on the mean renal perfusion pressure, whereas a possible influence of the pulsation of blood pressure on renin release has only occasionally been investigated, and the results are contradictory. such an influence on renin release cannot be excluded because pulsation is known to modulate arterial baroreceptors and vascular tone in some resistance vessels. in ...	1990	2186359
stimulation of renin synthesis in the hydronephrotic kidney during sodium depletion.		2008	2186360