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unravelling the pathogenic role of helicobacter pylori in peptic ulcer: potential new therapies and vaccines.the recognition that peptic ulcer is an infectious disease caused by the bacterium helicobacter pylori has revolutionized the approach to diagnosis and therapy of this condition. treatment of the symptoms of peptic ulcer with drugs that block acid secretion is already being replaced by antibiotic eradication of the causative agent. studies of the molecular events that lead to h. pylori pathogenesis have shown that clinical isolates can be divided into two groups, only one of which produces a cyt ...19947765388
rapid eradication of helicobacter pylori infection.current helicobacter pylori eradication therapy for peptic ulcer disease usually involves a 2-week course of either a bismuth preparation or omeprazole in combination with antibiotics. we have studied a shorter, 7-day course of treatment to assess efficacy and tolerability.19957766742
successful helicobacter pylori eradication incorporating a one-week antibiotic regimen.the optimum regimen for the eradication of helicobacter pylori remains unclear. the aim of this study was to determine the efficacy and tolerability of omeprazole 40 mg daily given for 2 weeks, plus amoxycillin 500 mg t.d.s. and metronidazole 400 mg t.d.s. given for the first 7 days, in the treatment of h. pylori associated peptic ulcer disease.19957766743
helicobacter pylori eradication--understandable caution but no excuse for inertia. 19957766750
helicobacter pylori and gastric cancer. 19957767239
helicobacter pylori in patients with intestinal metaplasia and in controls: a serological and biopsy study in four uk centres. uk sub-group of the ecp-euronut-intestinal metaplasia study group.the incidence of helicobacter pylori was compared in high and low risk gastric cancer areas. complete data were available on 116 age and sex matched sets of cases--patients with histologically proven intestinal metaplasia (im)--and two control groups, one non-im endoscoped controls (ec) and one non-endoscoped controls (nc) recruited from out-patient clinics. h. pylori status was determined by both serology and histology in individuals biopsied from three separate gastric sites. our data show an ...19957767244
[intestinal metaplasia of the gastric mucosa and its relation with gastric carcinoma].epidemical and morphological studies have show that there is an association between intestinal metaplasia (im) and gastric carcinoma, and it has been considered by many to be a possible marker of premalignant change. im is also a common finding in benign disease of the stomach, however, and recent studies have therefore been direct at identifying variants of intestinal metaplasia which may have a more specific association with gastric carcinoma. also, it has been demonstrated that exist another ...19947768424
isolation of the helicobacter pylori reca gene and involvement of the reca region in resistance to low ph.to understand the potential roles of the important dna repair protein reca in helicobacter pylori pathogenesis, we cloned the reca gene from h. pylori 84-183. degenerate pcr primers based on conserved reca protein regions were used to amplify a portion of h. pylori reca, which was used as a probe to isolate the full-length reca gene from h. pylori genomic libraries. the h. pylori reca gene encoded a protein of 347 amino acids with a molecular mass of 37.6 kda. as expected, h. pylori reca was hig ...19957768597
characterization of a helicobacter pylori neutrophil-activating protein.helicobacter pylori-associated gastritis is mainly an inflammatory cell response. in earlier work we showed that activation of human neutrophils by a cell-free water extract of h. pylori is characterized by increased expression of neutrophil cd11b/cd18 and increased adhesiveness to endothelial cells. the work reported here indicates that the neutrophil-activating factor is a 150,000-molecular-weight protein (150k protein). neutrophil proadhesive activity copurified with this protein, which is a ...19957768601
occurrence of gastric ulcers in gnotobiotic piglets colonized by helicobacter pylori.archival gastric tissues from 10 of 39 gnotobiotic piglets colonized with helicobacter pylori 26695 contained stromal leukocytic inflammation along with ulcers and erosions. in contrast, gastric tissues from 54 archival control piglets were devoid of both inflammation and ulcers. these data confirm the hypothesis that h. pylori infection alone is ulcerogenic.19957768620
comparative ultrastructural and functional studies of helicobacter pylori and helicobacter mustelae flagellin mutants: both flagellin subunits, flaa and flab, are necessary for full motility in helicobacter species.helicobacter mustelae causes chronic gastritis and ulcer disease in ferrets. it is therefore considered an important animal model of human helicobacter pylori infection. high motility even in a viscous environment is one of the common virulence determinants of helicobacter species. their sheathed flagella contain a complex filament that is composed of two distinctly different flagellin subunits, flaa and flab, that are coexpressed in different amounts. here, we report the cloning and sequence de ...19957768796
incidence and risk factors of duodenal ulcer. a retrospective cohort study.we evaluated the incidence and risk factors of duodenal ulcer (du) in a cohort of patients who had undergone esophagogastroduodenoscopy in our institution from 1978 to 1982, without then finding a gastric or duodenal ulcer. six hundred and twenty-one subjects entered the study, and 526 (84.7%) were traced in 1992. forty-one cases of du were found, an incidence rate of 6.7 per 1,000 person-years; the male/female ratio was 2:1. the diagnoses of peptic ulcer (pu) were validated by means of medical ...19957769187
helicobacter pylori infection and gastric metaplasia in the duodenum in china.biopsy specimens from antral and duodenal mucosa were obtained from 64 patients with active duodenal ulcer and from 78 with nonulcer dyspepsia. gastric metaplasia in the duodenal bulb was more frequent in patients with duodenal ulcer (82.5%) than in patients with dyspepsia and duodenitis (53.1%) or in patients with dyspepsia without duodenitis (34.5%). helicobacter pylori infection in the duodenal bulb was found more often in patients with moderate to severe gastric metaplasia (62.3%) than in pa ...19957769188
impact of infection by helicobacter pylori on the risk and severity of endemic cholera.to evaluate the relationship between helicobacter pylori infection and the subsequent risk and severity of endemic vibrio cholerae o1 diarrhea among rural bangladeshis, 285 children and adults with cholera (cases) and 881 contemporaneously selected community controls were studied. cases and controls were contrasted for h. pylori infection, as manifested by serum igg anti-h. pylori antibodies. although the overall risk of cholera was not significantly increased among h. pylori-infected subjects, ...19957769312
[bismuth. an old medicine of current interest].bismuth has been used to treat dyspepsia for more than a hundred years, and has now become an important element in the treatment of peptic ulcer disease. less than 1% of ingested bismuth is absorbed in the gastrointestinal tract and is excreted in the urine. bismuth forms a protective coating on the mucosa, it stimulates secretion of bicarbonate and has an effect on the g-cell and helicobacter pylori. bismuth gives equal ulcer healing rates as h2-receptor blocking agents, but causes significantl ...19957770830
helicobacter pylori in pediatric nonulcer dyspepsia: pathogen or commensal? 19957771413
the role of helicobacter pylori in children with recurrent abdominal pain.our major goals in this study were to determine the prevalence of helicobacter pylori among israeli children with recurrent abdominal pain and to establish whether a link exists between eradication of helicobacter pylori and the recovery from abdominal pain. the alternative target was to examine whether the serological test can replace endoscopy in children.19957771418
low dose, short-term triple therapy for cure of helicobacter pylori infection and healing of peptic ulcers.the aim of this study was to confirm the efficacy and tolerability of a new, low dose, short-term triple therapy for cure of helicobacter pylori infection, as suggested by bazzoli, in a larger population.19957771426
[the age-related characteristics of the immune reaction of the mucosa of the gastric antrum in chronic gastritis].stomach biopsies from 16 adult patients at the age from 18 to 55 years, 16 adults of 56-68 years and 23 children were studied histologically, immunohistochemically and morphometrically. the frequency of helicobacter pylori findings was dependent on the age. local production of igm and igg was higher in the adults of young and mature age. number of iga producing cells decreased and that of igg producing cells sharply increased in the aged persons; in this category also was increased the number of ...19957771933
uptake site of lansoprazole, a proton pump inhibitor, in human fundic mucosa: possible relevance with fibroblast and helicobacter pylori.to clarify the mechanism of the effect of lansoprazole in the healing of human gastric ulcer, the uptake sites of lansoprazole were studied using endoscopically biopsied specimens from the margin of the gastric ulcer. the specimens were incubated in a medium containing 3h-lansoprazole for 5 or 15 min., postfixed with 1% osmic acid and embedded in epon. the semithin or ultrathin sections were made and radioautographic emulsion films were applied by the wire-loop method. 30 days after the incubati ...19957773126
susceptibility of helicobacter pylori to antimicrobial agents: effect of sulglycotide.h. pylori is regarded as a primary etiologic factor in gastric disease and the therapies now include a combination of antimicrobial agents with antiulcer drugs. here, the effect of a new gastroprotective agent, sulglycotide, on the in vitro anti-h. pylori activity of metronidazole, erythromycin, tetracycline, and amoxycillin was assessed. the assays in the absence of sulglycotide gave mic value 0.10mg/l for erythromycin, 0.12mg/l for amoxycillin, 0.15mg/l for tetracycline and 14mg/l for metronid ...19957773183
potential animal models of helicobacter pylori infection in immunological and vaccine research.presence of helicobacter pylori in the human gastric mucosa is associated with chronic gastritis and promotes the formation of peptic ulceration. furthermore, long-term gastritis caused by the bacteria represents an increased risk of developing gastric cancer. much controversy remains about the pathogenic mechanisms by which h. pylori can induce disease because of the limitations of animal models and the relevance of in vitro observations to the in vivo disease process. studies of putative patho ...19957773242
cell surface characteristics of helicobacter pylori.helicobacter pylori is an important gastroduodenal pathogen of humans. immunological and structural studies have been performed on the phospholipids, lipopolysaccharides (lps) and some surface proteins of h. pylori strains. h. pylori lps has, in general, low immunological activity and this property may aid the survival of this chronic infection. nevertheless, h. pylori lps has been found to influence the quality of gastric mucin and to stimulate pepsinogen secretion, thereby contributing to gast ...19957773243
salivary specific igg is a sensitive indicator of the humoral immune response to helicobacter pylori.in humans, salivary antibodies are secreted during humoral immune response. helicobacter pylori infection is associated with systemic humoral immune response reflected by raised serum levels of specific igg. the present study was aimed at exploring whether salivary concentrations of specific h. pylori igg are a reliable indicator of h. pylori infection. serum and salivary samples were obtained from 291 subjects attending the gi clinic and tested for h. pylori-specific igg by a direct elisa (94% ...19957773244
isotypic analysis of specific antibody response in serum, saliva, gastric and rectal homogenates of helicobacter pylori-infected patients.the relationship between systemic and local humoral immune response to helicobacter pylori is poorly understood. to further address this issue we measured, using elisa, h. pylori-specific igg and iga antibodies in serum, saliva, gastric and rectal homogenates of h. pylori-infected patients. a total of 107 patients who underwent upper gi endoscopy and/or sigmoidoscopy were studied. the isotypic pattern of h. pylori-specific antibodies appeared to differ at the serum, salivary, gastric and rectal ...19957773245
investigation of helicobacter pylori ascorbic acid oxidating activity.helicobacter pylori sonicate was shown to oxidize ascorbic acid. ascorbic acid oxidation was determined by chromatography combined with electrochemical detection. water soluble ascorbic acid oxidase activity was rather independent of ph with a ph optimum around 2. by gel filtration the oxidizing activity co-eluted with an absorbency peak at 408 nm. the relative molecular mass (mr) was approximately 14,000. it is suggested that this oxidating activity was caused by a cytochrome c-like molecule. a ...19957773246
attachment, ingestion and intracellular killing of helicobacter pylori by human peripheral blood mononuclear leukocytes and mouse peritoneal inflammatory macrophages.the different steps of phagocytosis, attachment, ingestion and intracellular killing of cells of helicobacter pylori strain 17874 (expressing sialic acid-specific haemagglutinin) and cells of h. pylori strain 17875 (expressing non-sialic acid-specific haemagglutinin) have been studied. more cells of sialopositive h. pylori strain 17874 have been found attached to human peripheral blood mononuclear leukocytes (pbm) and mouse peritoneal inflammatory macrophages (pim) than cells of sialonegative h. ...19957773248
molecular analysis of helicobacter pylori populations in antral biopsies from individual patients using randomly amplified polymorphic dna (rapd) fingerprinting.in the present study, randomly amplified polymorphic dna (rapd) fingerprinting has been used to analyse multiple single colony isolates of helicobacter pylori from antral biopsies in an attempt to ascertain whether or not multiple strains are present in individual patients using single biopsy samples. the rapd fingerprints derived from single colonies obtained from the same biopsy specimen were in all cases indistinguishable. the previously noted heterogeneity between h. pylori strains from diff ...19957773249
development of a pcr-based technique for detection of helicobacter pylori.a primer-set was designed for specific detection of genes that encode for 16s rrna of helicobacter pylori, using direct polymerase chain reaction (pcr). the primers were selected in the hypervariable regions, derived from a complete small subunit 16s rrna sequence of the reference strain h. pylori ccug 17874. the primer-set amplified a 537 base pair (bp) sequence specifically from chromosomal h. pylori dna. amplification of purified chromosomal h. pylori dna was achieved at concentrations as low ...19957773250
gastric juice neopterin in helicobacter pylori infection.neopterin, a pteridine compound produced by macrophages activated by interferon-gamma, is widely used to assess the activation of cellular immunity. an elevation in serum or urinary neopterin reflects immune activation in many different disorders, including viral infections, cancer, autoimmune diseases or acute myocardial infarction, but less attention has been paid to neopterin concentration in other biological fluids. the aim of the present study was to examine neopterin concentration in gastr ...19957773251
topographic study of helicobacter pylori and hla-dr antigen expression on gastric epithelium.helicobacter pylori and hla-dr antigen expression on gastric epithelium, identified by an indirect immunoperoxidase staining method using monoclonal antibodies against h. pylori and hla-dr antigens, were studied topographically. fifty-nine biopsy specimens from 41 patients who had neither gastric cancer nor peptic ulcers were examined. h. pylori was observed predominantly over or on the surface epithelium, while hla-dr antigens were frequently expressed on the epithelium of the isthmus region. t ...19957773343
diagnosis of gastric adenocarcinoma using a scoring system: combined assay of serological markers of helicobacter pylori infection, pepsinogen i and gastrin.this study was carried out to develop a scoring system for the diagnosis of gastric adenocarcinoma (gac). a total of 686 subjects, 150 patients with gac, 182 with gastric ulcer, 127 with duodenal ulcer, and 227 subjects with negative findings, were enrolled. analysis of the likelihood ratio (lr) showed that patients with advanced age, ulcer in the stomach, low serum levels of pepsinogen i (pgi), low pgi x gastrin values, and low pgi/gastrin ratio were likely to have gac. of these indicators, the ...19957773344
serum anti-helicobacter pylori antibody and gastric carcinoma among young adults. research group on prevention of gastric carcinoma among young adults.helicobacter pylori is recognized as one of the possible causes of gastric carcinoma. there have been few studies on the relationship between h. pylori and gastric carcinoma in patients younger than 40 years.19957773928
influence of initial therapy on outcome of peptic ulcer.histamine 2 (h2) receptor antagonists, proton pump inhibitors, prostaglandin analogues, colloidal bismuth and sucralfate have all proved safe and effective in the initial treatment of peptic ulcer. yet, most ulcers will recur when treatment is stopped. continuous maintenance with h2 antagonists results in low symptomatic relapse, complications occur rarely, and such treatment is safe. an alternative is symptomatic self care (on-demand therapy), which provides an economic option for patients with ...19957777799
mucosal immune response to helicobacter pylori and cytotoxic mechanism.helicobacter pylori is widely accepted as a major pathogen in gastritis. the histologic features of h. pylori gastritis are the numerous infiltrating mononuclear cells (mncs) and neutrophils. it is not clear what role the infiltrating mncs and neutrophils play in h. pylori gastritis.19957777802
helicobacter pylori.helicobacter pylori is an important cause of chronic active gastritis and is strongly associated with peptic ulcer disease and gastric cancer. h. pylori colonizes the surface of the gastric epithelium with production of a number of factors, resulting in inflammation and an altered mucosa. h. pylori infection occurs world-wide and the mode of transmission most likely is from human to human via the fecal-oral and/or the oral-oral route. treatment and, in the future, prevention of this infection ma ...19957777803
the current role of helicobacter pylori eradication in clinical practice.helicobacter pylori is probably the commonest bacterial infection worldwide and is now accepted as the cause of chronic active type b gastritis. it is increasingly accepted as having a critical role in duodenal ulcer, where the prevalence of infection is 90 to 100%. more important is the dramatic reduction in duodenal ulcer recurrence after successful eradication of the organism to about 4% in a year compared to recurrences of up to 80% in those whose ulcers have been healed but in whom the infe ...19957777804
helicobacter pylori infection. 19957778192
dyspepsia and helicobacter pylori infection in rural south west cameroon. 19957778207
[does no helicobacter pylori mean no duodenal ulcer?]. 19937779166
diagnosis and treatment of helicobacter pylori infection in peptic ulcer disease. 19957779488
[helicobacter pylori in children: many questions, few answers]. 19957780534
[helicobacter pylori gastritis in children].the role of helicobacter pylori in chronic gastric and duodenal ulcer disease has now been proven in adults as well as in children.19957780537
mutations of the k-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around florence, italy.k-ras and p53 gene mutations in intestinal-type gastric carcinomas from a high-incidence area around florence, italy, were studied by single strand conformation polymorphism and dna sequencing analysis. single-strand conformation polymorphism analysis of k-ras indicated aberrant bands in 13 of 34 cases. sequencing revealed point mutations in 7 (including two at a previously unreported site in codon 11), a significantly higher frequency than reported in countries other than japan. no k-ras mutati ...19957780983
mechanism of helicobacter pylori-associated gastric mucosal injury.helicobacter pylori infection is associated with gastric mucosal damage and the infiltration of neutrophils. myeloperoxidase from neutrophils produces hypochlorous acid, which yields monochloramine in the presence of ammonia produced by urease enzyme of helicobacter pylori. the target cells of gastric mucosal damage are gastric mucosal cells and endothelial cells. we therefore tested the hypothesis that ammonium, hypochlorous acid, and monochloramine damage the target cells. we studied the in vi ...19957781456
antibiotic versus maintenance therapy in the prevention of duodenal ulcer recurrence. results of a multicentric double-blind randomized trial.reduction of gastric acid secretion by maintenance therapy and eradication of helicobacter pylori by antibiotic treatment have been shown to reduce duodenal ulcer relapse. this study compared the effect of two regimens, a 6-month maintenance on an h2 receptor antagonist versus a one-week antibiotic therapy, on the rate of duodenal ulcer relapse in duodenal ulcer patients with gastric h. pylori infection.19957781936
kinetics of substrate oxidation by whole cells and cell membranes of helicobacter pylori.oxygen uptake by helicobacter pylori cells and membranes was determined. cells from stirred broth cultures or agar plates, suspended in buffer, possessed a variable and apparently endogenous respiration which could be sustained for several hours. in contrast, oxygen consumption by cells from statically incubated broth cultures, in the absence of added substrate, was transient or undetectable. these latter cells, however, oxidised ethanol, fumarate, glucose, d-lactate, pyruvate and succinate, tho ...19957781988
helicobacter pylori: the place of the new macrolides in the eradication of the bacteria in peptic ulcer disease. 19957782116
[residual gastritis after gastrectomy and helicobacter pylori--its clinical significance].residual gastritis after gastrectomy brings the various symptoms such as abdominal pain, nausea, emesis and loss of appetite, and often hazards quality of life of the patient. bile reflux to the stomach is believed as one of the important pathogenesis of residual gastritis, however the prevention for bile reflux cannot always heal the gastritis. helicobacter pylori (h. pylori) is considered as one of the most important pathogenesis of gastroduodenal ulcer and gastritis, and h. pylori may possibl ...19957783378
effects of the clearing-heat and nourishing-stomach method in the treatment of chronic gastritis with positive campylobacter pylori. 19957783456
regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of helicobacter pylori infection. malt lymphoma study group.lymphoma of gastric-mucosa-associated lymphatic tissue (malt) type has been linked to infection with helicobacter pylori. we investigated the effect on malt lymphoma of eradicating h pylori infection. 33 patients with primary gastric low-grade malt lymphoma associated with h pylori gastritis were treated with omeprazole (120 mg daily) and amoxycillin (2.25 g daily) for 14 days to eradicate h pylori. in addition to histology, pcr was used to examine proliferation of monoclonal b cells before trea ...19957783535
helicobacter pylori eradication and reinfection. 19957783564
helicobacter pylori eradication and reinfection. 19957783565
helicobacter pylori eradication and reinfection. 19957783566
[antral gastritis in chronic alcoholism. role of cirrhosis and helicobacter pylori].antral gastritis is frequent in alcoholics. the role of h. pylori in the pathogenesis of gastritis in these patients is not well known. the aim of our study was to study the role of h. pylori and cirrhosis in the pathogenesis of antral gastritis in alcoholic patients.19957784401
[the physiopathology of duodenal ulcer: an attempt at a link between "classical" knowledge and helicobacter pylori infection]. 19957784659
helicobacter pylori in peptic ulcer disease. 19957786257
cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of helicobacter pylori.exogenous cholecystokinin (cck) is known to effect gastric secretory and motor functions but its physiological role in the control of these functions in healthy subjects and duodenal ulcer (du) patients is unknown.19947787215
epidemiology of helicobacter pylori infection in the people's republic of china.this paper presents a general review of the studies on the epidemiology of h. pylori infection in china. among 3,519 dyspeptic individuals presenting for endoscopy, h. pylori detectable rate was 61.2%. a higher prevalence of infection was found in patients with peptic ulcer. the prevalence of gastric metaplasia was 82.5% in patients with duodenal ulcer, 53.1% in duodenitis and 34.5% in normal duodenal mucosa. h. pylori infection is significantly more common in gastric cancer patients (58.9%) tha ...19957789221
helicobacter pylori-induced gastritis in the domestic cat.helicobacter pylori has been cultured from the inflamed gastric mucosae of naturally infected cats; the lesions in h. pylori-infected cat stomachs mimic many of the features seen in h. pylori-infected human stomachs. to determine whether h. pylori-negative specific-pathogen-free cats with normal gastric mucosae were susceptible to colonization by this bacterium and whether gastritis developed after infections, four h. pylori-negative cats treated with cimetidine were orally dosed three times wit ...19957790084
protein hpn: cloning and characterization of a histidine-rich metal-binding polypeptide in helicobacter pylori and helicobacter mustelae.helicobacter pylori is a human gastrointestinal pathogen involved in gastritis, duodenal ulcers, and gastric neoplasia. this microorganism produces large amounts of a urease which, like all known ureases, has nickel in the active site. we have identified a protein in clinical isolates of h. pylori and an identical protein in the ferret pathogen helicobacter mustelae that strongly binds ni2+ and zn2+. this protein has been named hpn to emphasize its origins in h. pylori and its affinity for nicke ...19957790085
acne rosacea and helicobacter pylori betrothed. 19957790135
factors affecting growth and susceptibility testing of helicobacter pylori in liquid media.in order to increase the database for in vitro growth and/or susceptibility testing in liquid media, we evaluated the growth of helicobacter pylori in broth media containing 5% sheep blood. we also compared the effect of bismuth on the growth of h. pylori in broth media containing 10% fetal calf serum with the effect on growth in media containing 0.5% starch. in contrast to the result seen with agar, we found that sheep blood, whether whole or laked, inhibited the growth of h. pylori in broth me ...19957790430
long-term colonization with single and multiple strains of helicobacter pylori assessed by dna fingerprinting.the gastric pathogen helicobacter pylori establishes long-term chronic infections that can lead to gastritis, peptic ulcers, and cancer. the species is so diverse that distinctly different strains are generally recovered from each patient. to better understand the dynamics of long-term carriage, we characterized h. pylori isolates from initial and follow-up biopsy specimens from a patient population at high risk of h. pylori infection and gastric cancer. eighty-five isolates were obtained from 2 ...19957790461
[gastrotsepin in the therapy and prevention of peptic ulcer exacerbations associated with helicobacter pylori bacteriosis]. 19957791310
long-term sequelae of helicobacter pylori gastritis.chronic helicobacter pylori gastritis has been put forward as a risk factor for development of gastric mucosal atrophy and gastric cancer. the purpose of our study was to investigate the long-term effects of h pylori gastritis on the gastric mucosa. we prospectively studied 49 subjects negative for h pylori and 58 positive subjects for a mean follow-up of 11.5 years (range 10-13 years). serum samples were obtained at the initial and follow-up visits for determination of h pylori igg antibodies. ...19957791437
helicobacter pylori: a human pathogen. 19957791469
helicobacter pylori: a human pathogen. 19957791470
helicobacter pylori: a human pathogen. 19957791471
string test for helicobacter pylori. 19957791472
[analysis of inflammatory reaction and epithelial proliferation in corpus mucosa of the stomach. a contribution to carcinogenesis].to elucidate conflicting evidence concerning the role of helicobacter pylori (hp) in the evolution of gastric carcinoma, a retrospective analysis was performed on the corpus mucosa of gastric surgical specimens removed from patients with gastric carcinoma (n = 53) and pancreatic carcinoma (n = 45). prevalence, activity and degree of chronic active gastritis (cag) were investigated. furthermore, proliferative activity was determined by the expression of the ki67 antigen in epithelial cells of the ...19957792270
[gastroduodenal ulcer disease: update on pathogenesis].gastroduodenal ulcer disease comprises a heterogeneous group of different diseases resulting uniformly in a mucosal defect reaching beyond the muscularis mucosae. consequently, a single unifying pathogenesis of ulcer disease does not exist but only a rather general concept that ulcers develop when mucosa-injuring factors outweigh the mucosa-protecting factors. according to this concept, ulcers develop within a broad range of different possibilities in the relation of mucosa-injuring factors to i ...19957792467
relative risks of age, gender, nationality, smoking, and helicobacter-pylori-infection in duodenal and gastric ulcer and interactions.a logistic regression model was applied to assess risk factors and diagnostic predictors in duodenal and gastric ulcer, as well as in unspecific changes of gastric mucosa. in the latter group smoking, epigastric distress, and pain were associated with elevated relative risks. in the gastric ulcer model, increased odds were found for age, german nationality, smoking, and low and high urease activity of antral mucosa. this holds for duodenal ulcer, too; however interactions between complaints, ure ...19957793117
helicobacter pylori eradication in the treatment and differential diagnosis of giant folds in the corpus and fundus of the stomach.in an earlier study, we were able to show that giant fold gastritis is probably a special form of helicobacter pylori-associated gastritis. proof of this contention, however--namely regression of the giant folds following eradication of the organism--in a large number of patients was not then possible. to rectify this, helicobacter pylori (hp) eradication treatment with omeprazole and amoxicillin was applied to 47 patients with hp gastritis and giant folds (5 patients with giant folds localized ...19957793118
rapid large-scale growth of helicobacter pylori in flasks and fermentors.we developed procedures for large-scale cultivation of helicobacter pylori in flasks and fermentors. flasks incubated closed under a microaerophilic gas phase with a cotton plug covered by a plastic bag, followed by removal of the bag after 8 h, gave excellent growth. growth in a 10-liter fermentor led to excessive foaming if the medium was sparged with gas; silicone- or polyglycol-based antifoaming agents were severely inhibitory. use of fermentor surface gassing, first with a microaerophilic 6 ...19957793966
effect of long term intramuscular gold therapy on the seroprevalence of helicobacter pylori in patients with early rheumatoid arthritis. 19957794057
comparison of biopsy sites for the histopathologic diagnosis of helicobacter pylori: a topographic study of h. pylori density and distribution.the histologic demonstration of characteristic curved, spiral bacilli on the gastric mucosa is considered the gold standard for the diagnosis of helicobacter pylori infection. however, in some cases the urea breath test or serologic tests may be positive, yet gastric biopsy specimens fail to reveal h. pylori. the objectives of this study were (1) to analyze the density and distribution of h. pylori in different regions of the stomach, (2) to ascertain which area of the stomach is a preferential ...19947794303
upper gastrointestinal tract.drug therapy for upper gastrointestinal disease in the elderly must be moderated by the likelihood of increased sensitivity to the side effects of drugs. for example, in the frail elderly with helicobacter-associated duodenal ulcers, maintenance therapy with an h2-receptor antagonist or omeprazole may be preferable to attempting to eradicate helicobacter pylori with the current antimicrobial regimens.19957794323
[course of histological lesions of the gastric mucosa after eradication of h. pylori in patients with duodenal ulcer. initial study and 6-month follow-up].helicobacter pylori is the major etiologic agent of chronic active gastritis, and it may be isolated from the gastric mucosa in a high proportion of patients with duodenal ulcer.19957794634
twelve-month omeprazole vs ranitidine in the treatment of helicobacter pylori positive patients with healed duodenal ulcer.we evaluated the results of a 12-month treatment using different regimens of omeprazole at the dose of 20 mg daily (three day week-end treatments and every other day) and of 150 mg nocte of ranitidine on helicobacter pylori status and on preventing duodenal ulcer relapses in 140 helicobacter pylori positive patients with healed duodenal ulcer. only every-other-day omeprazole suppresses helicobacter pylori after 3 month therapy (p < 0.001), after 6 months (p < 0.001) and 12 months (p < 0.05). aft ...19957795283
peptic ulcer and duodenal stenosis: role of helicobacter pylori infection.a 17-year-old boy who developed a symptomatic duodenal ulcer at 10 years of age with melena, and was then treated continuously for 6 years with ranitidine therapy that only partially controlled symptoms and peptic lesions, came to us with vomiting due to duodenal bulb stenosis and active ulcer. four months of omeprazole (40 mg/die o.m.) did not modify the endoscopic picture. the diagnosis of h. pylori infection and its treatment with triple therapy led to the cure of both duodenal ulcer and bulb ...19957795284
helicobacter pylori infection in perforated peptic ulcer disease.this study examined a possible aetiological agent, namely, helicobacter pylori, in perforated peptic ulcer disease and its relationship to persisting ulcer. twenty-nine patients with perforated peptic ulcer underwent simple closure of the perforation at laparotomy. a 13c urea breath test carried out on the eighth day after operation was positive in 24 patients. fourteen of 17 patients who underwent upper gastrointestinal endoscopy 6 weeks after discharge from hospital had a positive 13c urea bre ...19957796009
the history of live bacterial vaccines.recent developments have made it possible to construct non-reverting live bacterial vaccine candidates with defined deletions of two or more genes. such vaccines have proven safe and immunogenic in human volunteers. since the virulent parent strains are only pathogenic to man (s. typhi, s. flexneri, and v. cholerae), they pose no threat to the environment. besides holding promise as efficacious vaccines for protection against typhoid fever, bacillary dysentery and cholera, the attenuated strains ...19957796956
oral immunization with helicobacter pylori urease b subunit as a treatment against helicobacter infection in mice.eradication of helicobacter pylori infections in humans results in the healing of gastritis and gastric ulcers. this study used a mouse model to test whether oral vaccination can cure helicobacter infection and gastritis.19957797009
helicobacter pylori: a diagnostic dilemma and a dilemma of diagnosis. 19957797030
eradication of helicobacter pylori: in search of a regimen the patient may accept. 19957797036
detection of the intragastric sites at which helicobacter pylori evades treatment with amoxycillin and cimetidine.treatment of helicobacter pylori infection with amoxycillin is known to reduce the bacterial load to undetectable levels, while not eradicating the infection. it seems, therefore, that bacteria escape treatment at a 'sanctuary site'. this study examined whether such a site existed in the gastric antrum, body, or fundus. twenty two patients with h pylori infection and duodenal ulcer disease were treated for one week with amoxycillin (500 mg three times a day) and cimetidine (800 mg at night). bef ...19957797114
prevalence of helicobacter pylori in patients with gall stones before and after cholecystectomy: a longitudinal study.fifty six patients with gall stones were enrolled in this study to assess the presence of helicobacter pylori in gastric mucosa before and after cholecystectomy. samples were taken from gastric juice and antral mucosa through endoscopy performed on these patients before and after the operation. gastric juice was examined for bile salt concentration as an indicator of duodenogastric reflux. antral mucosa was studied for the presence of h pylori and inflammatory response. duodenogastric reflux was ...19957797115
primary gastric lymphoma in clinical practice 1973-1992.this study assessed the presentation, treatment, and prognosis of primary gastric lymphoma in general hospital practice and its relation to infection with helicobacter pylori. the number of patients that would on the current recommendations have been suitable for h pylori eradication therapy was also examined. all lymphomas were graded according to a standard classification of gut lymphoma into high and low grade disease. forty five patients (mean age 65 years) were identified. the overall five ...19957797116
helicobacter pylori infection in rural settlements (kibbutzim) in israel.helicobacter pylori (hp) is accepted as a major cause of type b gastritis, which is strongly associated with peptic ulcer disease. epidemiological studies have indicated a correlation of hp infection and socioeconomic class.19957797348
can the radiologist recognize helicobacter pylori gastritis?to evaluate radiologic findings of helicobacter pylori (h. pylori) in the upper gastrointestinal (ugi) tract, we retrospectively reviewed consecutive records of 676 symptomatic adults with gastric biopsies (224 positive) and 150 symptomatic adults with rapid urease tests (57 positive). all the ugi series of patients with positive biopsies or urease tests for h. pylori were compared with the ugi series of patients with negative urease tests. ugi examinations were evaluated blindly by two gastroin ...19957797826
oral immunization with recombinant helicobacter pylori urease induces secretory iga antibodies and protects mice from challenge with helicobacter felis.helicobacter pylori, a gram-negative spiral bacterium, is the cause of chronic superficial (type b) gastritis and peptic ulcer disease. the urease enzyme of h. pylori was expressed as an inactive recombinant protein in escherichia coli, purified as particulate structures of 550-600 kda molecular mass with a diameter of approximately 12 nm. given orally, 5 micrograms of urease with an appropriate mucosal adjuvant, such as the labile toxin of e. coli, protected 60%-100% of mice against challenge w ...19957797906
analysis of genetic diversity in cytotoxin-producing and non-cytotoxin-producing helicobacter pylori strains.analysis of 32 helicobacter pylori strains indicated a strong association between the presence of the caga gene and a specific type of vaca allele found predominantly in cytotoxin-producing strains (p < .001). to determine whether tox+/caga+ and tox-/caga- strains constituted two separate noncombining lineages, sequences of the h. pylori urec gene, cyss homologue, and the intergenic region between cyss and vaca were determined for multiple strains. the mean levels of nucleotide identity in the t ...19957797934
[basic and clinical study of helicobacter pylori infections]. 19947798736
[detection of helicobacter pylori by the urease test in 244 patients].the authors report the results of the detection of helicobacter pylori (hp) in gastric mucosa by the urease test, in 244 patients between january 1989 and august 1991. the overall prevalence of hp was 38.1%. it was 19.5% in patients with normal upper gastrointestinal endoscopy (ue), 61% in duodenal ulcer (p < 0.001) and 68.7% in congestive antritis (p < 0.001), significantly higher than in controls. there was no significant difference between controls and patients with erosive antritis or healed ...19937799411
genetic abnormalities during transition from helicobacter-pylori-associated gastritis to low-grade maltoma.the helicobacter-associated transition from chronic gastritis to maltoma (lymphoma of mucosa-associated lymphoid tissue) may require genetic change in the host. we have studied gastrectomy specimens from twelve cases of primary b-cell gastric lymphoma showing evidence of chronic gastritis and low-grade or high-grade maltoma to look for allele imbalance at microsatellites for six tumour-suppressor genes. we detected allelic imbalance at two of these loci (dcc in three, apc in two). in two dcc cas ...19957799702
antibacterial treatment of gastric ulcers associated with helicobacter pylori.there is a strong association between infection with helicobacter pylori and gastric ulcers that are unrelated to the use of nonsteroidal antiinflammatory medications. we studied the efficacy of antibacterial therapy without medication to suppress gastric acid for the treatment of patients with h. pylori infection and gastric ulcers unrelated to the use of nonsteroidal agents.19957800005
detection of helicobacter pylori in endoscopic biopsies in sudan.we studied the prevalence of helicobacter pylori in sudanese subjects with gastroduodenal inflammation. h. pylori was looked for in biopsy specimens taken from the antrum by two methods: rapid urease test [campylobacter-like organism (clo) test] and culture using skirrow's selective supplement. one hundred subjects were studied. h. pylori was found in 80% of patients with gastritis, 56% of patients with duodenal ulcer, 60% of patients with duodenitis and 16% of normal control subjects. it was ne ...19947801358
helicobacter pylori brews ferment in malt lymphoma. 19957801928
modified short-term triple therapy--ranitidine, clarithromycin, and metronidazole--for cure of helicobacter pylori infection. 19957801936
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