Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| rapamycin and everolimus facilitate hepatitis e virus replication: revealing a basal defense mechanism of pi3k-pkb-mtor pathway. | humans are frequently exposed to hepatitis e virus (hev). nevertheless, the disease mainly affects pregnant women and immunocompromised individuals. organ recipients receiving immunosuppressants, such as rapalogs, to prevent rejection have a high risk for developing chronic hepatitis following hev infection. rapalogs constitute potent inhibitors of mtor including rapamycin and everolimus. as a master kinase, the mechanism-of-action of mtor is not only associated with the immunosuppressive capaci ... | 2014 | 24859454 |
| pcr detection and analysis of potentially zoonotic hepatitis e virus in french rats. | hepatitis e virus has been detected in a wide range of animals. while genotypes 1-2 of this virus infect only humans, 3-4 can spread from animals to humans and cause sporadic cases of human disease. pig, and possibly also rats, may act as a reservoir for virus. from a public health perspective it is important to clarify the role of rats for infection of humans. rats often live close to humans and are therefore of special interest to public health. rats live of waste and inside the sewage system ... | 2014 | 24886183 |
| multiplex hydrolysis probe real-time pcr for simultaneous detection of hepatitis a virus and hepatitis e virus. | detection of hepatitis viral infections has traditionally relied on the circulating antibody test using the enzyme-linked immunosorbent assay. however, multiplex real-time pcr has been increasingly used for a variety of viral nucleic acid detections and has proven to be superior to traditional methods. hepatitis a virus (hav) and hepatitis e virus (hev) are the major causes of acute hepatitis worldwide; both hav and hev infection are a main public health problem. in the present study, a one-step ... | 2014 | 24886818 |
| past and present of hepatitis e in the netherlands. | recent studies show that endemic hepatitis e virus (hev) infection occurs frequently in some developed countries. in the netherlands in 2013, the routine screening of 35,220 plasma donations for hev rna showed 20 donors to be viremic (1:1761), which seems to contradict reports of declining hev seroprevalence in the recent past. | 2014 | 24889277 |
| robust manufacturing and comprehensive characterization of recombinant hepatitis e virus-like particles in hecolin(®). | the hepatitis e virus (hev) vaccine, hecolin(®), was licensed in china for the prevention of hev infection and hev-related diseases with demonstrated safety and efficacy [1,2]. the vaccine is composed of a truncated hev capsid protein, p239, as the sole antigen encoded by open reading frame 2 and produced using escherichia coli platform. the production of this virus-like particle (vlp) form of the antigen was successfully scaled up 50-fold from a bench scale to a manufacturing scale. product con ... | 2014 | 24892250 |
| severe acute hepatitis e in an hiv infected patient: successful treatment with ribavirin. | in industrialized countries, most cases of hepatitis e virus (hev) infection in humans are autochthonous, mainly through foodborne and zoonotic transmission routes. in europe, genotype 3 is a cause of acute self-limiting viral hepatitis, but can also be responsible for chronic hepatitis in immunocompromised patients. ribavirin has been successfully used in the treatment of chronic hepatitis e and in a few cases of severe acute hepatitis e in immunocompetent patients. we report here the case of a ... | 2014 | 24894604 |
| hepatitis e virus serosurvey among pet dogs and cats in several developed cities in china. | infection by hepatitis e virus (hev), as a zoonotic disease virus, is well studied in pigs in china, but few studies in pets have been performed. this study was designed to characterize the prevalence of hev infection among pet dogs and cats in major metropolitan areas of china. we conducted a seroepidemiological survey from 2012 to 2013 in 5 developed cities, beijing, shanghai, canton, shenzhen and macao, by enzyme-linked immunosorbent assay (elisa). the overall hev seroprevalence in 658 dog an ... | 2014 | 24896257 |
| a systematic review of the epidemiology of hepatitis e virus in africa. | hepatitis e virus (hev) infection is a newly recognized serious threat to global public health and africa is suspected to be among the most severely affected regions in the world. understanding hev epidemiology in africa will expedite the implementation of evidence-based control policies aimed at preventing the spread of hev including policies for the use of available resources such as hev vaccines. | 2014 | 24902967 |
| older men with unexplained hepatitis. | a 59-year-old caucasian man presented with painless jaundice for 6 weeks. he drank 70 units of alcohol per week. examination revealed jaundice, spider angiomata and a 3 cm firm hepatomegaly. initial bloods: bilirubin 152 µmol/l, alanine aminotransferase 1484 iu/l, alkaline phosphatase 130 iu/l, γ-glutamyl-transpeptidase 1224 iu/l and international normalised ratio 1.1. a standard liver screen was normal, and an abdominal ultrasound/ct scan suggested cirrhosis, confirmed by liver biopsy on day 5. ... | 2014 | 24903723 |
| hepatitis e infection in patients with severe acute alcoholic hepatitis. | hepatitis e virus (hev) infection is a known cause of acute-on-chronic liver failure in developing countries, but its implication in western countries remains unknown. hev burden in the setting of severe acute alcoholic hepatitis (aah) was assessed. | 2015 | 24904954 |
| transfusion-transmitted hepatitis e in germany, 2013. | the reported igg seroprevalence against hepatitis e virus (hev) in german blood donations is 6.8%, and hev rna detected in 0.08%, but documented evidence for hev transmission is lacking. we identified two donations from a single donor containing 120 iu hev rna/ml plasma and 490 iu/ml. an infectious dose of 7,056 iu hev rna was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic hev. further, transmission was probable in an immunocompetent child. | 2014 | 24906377 |
| optimization of the elution buffer and concentration method for detecting hepatitis e virus in swine liver using a nested reverse transcription-polymerase chain reaction and real-time reverse transcription-polymerase chain reaction. | the aim of this study was to develop an optimal technique for detecting hepatitis e virus (hev) in swine livers. here, three elution buffers and two concentration methods were compared with respect to enhancing recovery of hev from swine liver samples. real-time reverse transcription-polymerase chain reaction (rt-pcr) and nested rt-pcr were performed to detect hev rna. when phosphate-buffered saline (pbs, ph 7.4) was used to concentrate hev in swine liver samples using ultrafiltration, real-time ... | 2014 | 24907649 |
| decline in hepatitis e virus antibody prevalence in southeastern germany, 1996-2011. | in the past decade, an increasing frequency of acute hepatitis e was noted in germany and other european countries. moreover, a high prevalence (17%) of hepatitis e virus (hev) immunoglobulin g antibodies (anti-hev) was recently found in the adult german population. although this suggests an emerging pathogen, reports from other countries gave hints to a completely new aspect: a possible decrease in anti-hev prevalence during the last decades. to investigate the time trends of hepatitis e in sou ... | 2014 | 24912687 |
| seroprevalence of seven zoonotic pathogens in pregnant women from the caribbean. | studies examining the prevalence of zoonotic agents in the caribbean are very limited. the objective of this study was to examine the seroprevalence of seven zoonotic agents among individuals residing on 10 english-speaking caribbean countries. sera from healthy, pregnant women were collected from antigua-barbuda, belize, bermuda, dominica, grenada, jamaica, montserrat, st. kitts-nevis, st. lucia, and st. vincent-grenadines and tested for the presence of igg antibodies to dengue virus, hepatitis ... | 2014 | 24914001 |
| survey of canadian retail pork chops and pork livers for detection of hepatitis e virus, norovirus, and rotavirus using real time rt-pcr. | over the past 15 years, hepatitis e virus (hev), norovirus (nov), and rotavirus (rv) have been hypothesized to be potentially zoonotic; swine and pork have been suggested as possible human infection sources for all 3 viruses. our objective was to estimate hev, nov, and rv prevalence and load on canadian retail pork chops and livers. using the canadian integrated program for antimicrobial resistance surveillance (cipars) sampling platform, pork livers (n=283) and chops (n=599) were collected, pro ... | 2014 | 24929681 |
| hepatitis e prevalence among hiv infected patients with elevated liver enzymes in the netherlands. | in recent years chronic hepatitis e virus (hev) infections have been reported in immunosuppressed patients, including hiv-positive patients with low cd4 cell counts. because of delayed anti-hev seroconversion in patients with cd4 cell count<200 cells/ml it is difficult to draw firm conclusions on hev-seroprevalence in a population of hiv positive patients. | 2014 | 24929755 |
| detection of serum antibodies to hepatitis e virus in domestic pigs in italy using a recombinant swine hev capsid protein. | the hepatitis e virus (hev) has been detected in both humans and animals, particularly pigs, worldwide. several evidences, including human infection following consumption of raw contaminated meat, suggest a zoonotic transmission of hev. in italy, large circulation of genotype 3 hev has been reported in swine, and recent studies have confirmed the involvement of this genotype in autochthonous human cases. | 2014 | 24934984 |
| naturally occurring animal models of human hepatitis e virus infection. | hepatitis e virus (hev) is a single-stranded, positive-sense rna virus in the family hepeviridae. hepatitis e caused by hev is a clinically important global disease. there are currently four well-characterized genotypes of hev in mammalian species, although numerous novel strains of hev likely belonging to either new genotypes or species have recently been identified from several other animal species. hev genotypes 1 and 2 are limited to infection in humans, whereas genotypes 3 and 4 infect an e ... | 2014 | 24936039 |
| spf rabbits infected with rabbit hepatitis e virus isolate experimentally showing the chronicity of hepatitis. | this study focused on investigating the pathogenesis seen in specific-pathogen-free (spf) rabbits following infection with a homologous rabbit hev isolate (chn-bj-rb14) and comparing it to that seen following infection with a heterologous swine genotype 4 hev isolate (chn-xj-sw13). three of the four animals inoculated with the homologous rabbit hev became infected, exhibiting an intermittent viremia, obvious fluctuations of liver function biomarkers alanine aminotransferase (alt) and aspartate a ... | 2014 | 24937350 |
| ribavirin for chronic hepatitis e virus infection. | 2014 | 24941183 | |
| ribavirin for chronic hepatitis e virus infection. | 2014 | 24941184 | |
| ribavirin for chronic hepatitis e virus infection. | 2014 | 24941185 | |
| ribavirin for chronic hepatitis e virus infection. | 2014 | 24941186 | |
| hepatic flares in chronic hepatitis c: spontaneous exacerbation vs hepatotropic viruses superinfection. | the hepatitis c virus (hcv) causes an acute infection that is frequently asymptomatic, but a spontaneous eradication of hcv infection occurs only in one-third of patients. the remaining two-thirds develop a chronic infection that, in most cases, shows an indolent course and a slow progression to the more advanced stages of the illness. nearly a quarter of cases with chronic hepatitis c (chc) develop liver cirrhosis with or without hepatocellular carcinoma. the indolent course of the illness may ... | 2014 | 24944463 |
| open reading frame 3 of genotype 1 hepatitis e virus inhibits nuclear factor-κappa b signaling induced by tumor necrosis factor-α in human a549 lung epithelial cells. | hepatitis e virus (hev) is one of the primary causative agents of acute hepatitis, and represents a major cause of severe public health problems in developing countries. the pathogenesis of hev is not well characterized, however, primarily due to the lack of well-defined cell and animal models. here, we investigated the effects of genotype 1 hev open reading frame 3 (orf3) on tnf-α-induced nucleus factor-κappa b (nf-κb) signaling. human lung epithelial cells (a549) were transiently transfected w ... | 2014 | 24959724 |
| epidemiological investigation of the jaundice outbreak in lalkuan, nainital district, uttarakhand. | in march 2013, cases of acute hepatitis were reported from lalkuan, nainital district. we investigated the outbreak to identify the source of infection and to facilitate control measures. | 2014 | 24963225 |
| hepatitis e rorf2p stimulated and unstimulated peripheral expression profiling in patients with self-limiting hepatitis e infection. | to improve the current knowledge on the involvement of peripheral lymphocytes in hepatitis e virus (hev) associated pathogenesis, we analyzed alterations in (1) immunophenotypic expressions (by flow cytometry) and (2) gene expression patterns (by taqman low density array) of activatory, inhibitory, integrin, homing, ectonucleotidase machinery, costimulatory, inflammatory markers, and t regulatory cells (treg) associated cytokines on hev rorf2p stimulated and unstimulated pbmcs of 43 acute hev pa ... | 2014 | 24963498 |
| transmission, diagnosis, and management of hepatitis e: an update. | hepatitis e virus (hev) infection is an important public health concern in many developing countries, causing waterborne outbreaks as well as sporadic autochthonous hepatitis. hev is mainly transmitted by the fecal-oral route in endemic areas through drinking of contaminated water. however, zoonotic transmission from animal reservoirs to humans has also been suggested. three additional routes of hev transmission have been proposed to occur: blood borne, human to human, and vertical transmission ... | 2014 | 24966702 |
| hepatitis e virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies. | our previous studies indicated that hepatitis e virus (hev) forms membrane-associated particles in the cytoplasm, most likely by budding into intracellular vesicles, and requires the multivesicular body (mvb) pathway to release virus particles, and the released hev particles with a lipid membrane retain the trans-golgi network protein 2 on their surface. to examine whether hev utilizes the exosomal pathway to release the virus particles, we analysed whether the virion release from plc/prf/5 cell ... | 2014 | 24970738 |
| hepatitis e virus and fulminant hepatitis--a virus or host-specific pathology? | fulminant hepatitis is a rare outcome of infection with hepatitis e virus. several recent reports suggest that virus variation is an important determinant of disease progression. to critically examine the evidence that virus-specific factors underlie the development of fulminant hepatitis following hepatitis e virus infection. | 2015 | 24974734 |
| hepatitis e virus seroprevalence in haemodialysis patients in zanjan province, islamic republic of iran. | hepatitis e virus (hev) infection is the most common form of acute hepatitis in adults in endemic regions of asia. in a descriptive, cross-sectional study, anti-hev antibody was measured in patients referred to the 2 haemodialysis centres in zanjan city, islamic republic of iran. among 93 patients with chronic renal failure, mean age 57.0 (sd 18.5) years, antibodies against hev were positive in 25 (26.9%) patients. hev infection was not significantly associated with sex, age, educational level, ... | 2013 | 24975304 |
| genetic characterization and serological prevalence of swine hepatitis e virus in shandong province, china. | hepatitis e virus (hev), the causative agent of hepatitis e, is classified into four major genotypes (1 to 4) and swine is the main natural reservoir for genotypes 3 and 4. in this study, a total of 106 bile samples from a slaughterhouse in the shandong province of china were tested for the partial orf2 gene of hev by rt-npcr to determine the virus genotypes, and two indirect elisa were developed for the detection of swine hev specific igm and igg antibodies in 980 serum samples from 24 farms, i ... | 2014 | 24975641 |
| estimation of hepatitis e virus (hev) pig seroprevalence using elisa and western blot and comparison between human and pig hev sequences in belgium. | zoonotic transmission of hepatitis e virus (hev) is of special concern, particularly in high income countries were waterborne infections are less frequent than in developing countries. high hev seroprevalences can be found in european pig populations. the aims of this study were to obtain prevalence data on hev infection in swine in belgium and to phylogenetically compare belgian human hev sequences with those obtained from swine. an elisa screening prevalence of 73% (95% ci 68.8-77.5) was deter ... | 2014 | 24975642 |
| seroprevalence and evolutionary dynamics of genotype 4 hepatitis e virus in shandong province, china. | to investigate the seroprevalence and evolutionary dynamics of hepatitis e virus (hev) and assess the ancestor of hevs in china's shandong province. | 2014 | 24976732 |
| seroepidemiology of hepatitis e virus infection in general population in rural durango, mexico. | the seroepidemiology of hepatitis e virus (hev) infection in rural areas in mexico has been poorly studied. | 2014 | 24976837 |
| chronic hepatitis e in solid-organ transplantation: the key implications of immunosuppressants. | solid-organ recipients infected with hepatitis e virus (hev) bear an extremely high risk of developing chronic hepatitis, although this virus only causes acute infection in the general population. immunosuppressive medication universally used after transplantation to prevent organ rejection appears to be a main risk factor for developing chronic infection. this review aims to overview and emphasize the current clinical and experimental evidence regarding the key implications of immunosuppressant ... | 2014 | 24977682 |
| hepatitis e virus infection in hematopoietic stem cell transplant recipients. | recipients of allogeneic stem cell transplantations are at risk of acquiring acute hepatitis e virus (hev) infection, leading to chronicity. we review the incidence, sequela, extrahepatic manifestations, and treatment of hepatitis due to hev infection in allogeneic hematopoietic stem cell transplantation (allohsct) recipients. | 2014 | 24977683 |
| incidence and natural history of hepatitis e virus coinfection among hiv-infected patients. | to know the prevalence, incidence and factors associated with hepatitis e virus (hev) infection in hiv-infected individuals in spain, as well as to provide information on the natural history of hiv/hev coinfection. | 2014 | 24979724 |
| hepatitis e virus seroprevalence among blood donors in jiangsu province, east china. | hepatitis e virus (hev) infection is responsible for over 50% of acute viral hepatitis cases, and the blood transfusion route has emerged as a possible means of sporadic hev infection. the aim of this study was to determine the seroprevalence of hev among blood donors in east china. | 2014 | 24981426 |
| assessment of airborne virus contamination in wastewater treatment plants. | occupational exposure to bioaerosols in wastewater treatment plants (wwtp) and its consequence on workers' health are well documented. most studies were devoted to enumerating and identifying cultivable bacteria and fungi, as well as measuring concentrations of airborne endotoxins, as these are the main health-related factors found in wwtp. surprisingly, very few studies have investigated the presence and concentrations of airborne virus in wwtp. however, many enteric viruses are present in wast ... | 2014 | 24981824 |
| occurrence of hepatitis e virus infection in acute hepatitis in thailand. | hepatitis e virus (hev) infection is one of the enterically transmitted types of hepatitis. the present study was undertaken to estimate the occurrence of hev infection in sporadic acute hepatitis in thailand. serum samples were obtained from 614 suspected acute hepatitis patients at two large hospitals in bangkok during 2008, 2009, and 2011. acute hepatitis e was identified by the presence of anti-hev igm (4.8%) using indirect elisa kits and/or hev rna (4.5%) by a semi-nested reverse transcript ... | 2014 | 24984976 |
| branched-linear and agglomerate protein polymers as vaccine platforms. | many viral structural proteins and their truncated domains share a common feature of homotypic interaction forming dimers, trimers, and/or oligomers with various valences. we reported previously a simple strategy for construction of linear and network polymers through the dimerization feature of viral proteins for vaccine development. in this study, technologies were developed to produce more sophisticated polyvalent complexes through both the dimerization and oligomerization natures of viral an ... | 2014 | 24985736 |
| consensus proposals for classification of the family hepeviridae. | the family hepeviridae consists of positive-stranded rna viruses that infect a wide range of mammalian species, as well as chickens and trout. a subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. current published descriptions of the taxonomical divisions within the family hepeviridae are contradictory in relation to the assignment of species and genotypes. through analysis of existing sequence information ... | 2014 | 24989172 |
| consensus proposals for classification of the family hepeviridae. | the family hepeviridae consists of positive-stranded rna viruses that infect a wide range of mammalian species, as well as chickens and trout. a subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. current published descriptions of the taxonomical divisions within the family hepeviridae are contradictory in relation to the assignment of species and genotypes. through analysis of existing sequence information ... | 2014 | 24989172 |
| hepatitis e virus seroprevalence in the national health and nutrition examination survey: facts trump opinion. | 2015 | 24995541 | |
| hepatitis e virus seroprevalence in the united states: no easy answers. | 2015 | 24995930 | |
| first case report of an acute hepatitis e subgenotype 3c infection during pregnancy in germany. | hepatitis e is usually a self-limiting disease and an important cause of acute hepatitis in endemic countries in asia and africa. however, the mortality rate for pregnant women infected with hepatitis e virus (hev) in this area is about 25%. in germany, sporadic cases of acute hepatitis e infections have been described and the number of autochthonous infections is increasing. here we report an autochthonous hev subgenotype 3c infection in a 27-year old pregnant woman. this is the first documente ... | 2014 | 24996764 |
| first report of hepatitis e virus circulation in domestic pigs in nigeria. | hepatitis e virus (hev) is an important cause of acute hepatitis in humans. zoonotic transmission between pigs and humans has been confirmed. human hev infection is common in nigeria; however, characterization of hev infection in other species was lacking. the objective of this study was to investigate hev infection in nigerian pigs. a total of 286 serum samples from six states in nigeria were tested for presence of anti-hev igg. ninety fecal samples from one of these states (plateau state) were ... | 2014 | 25002299 |
| hepatitis e in patients with hepatic disorders and hiv-infected patients in croatia: is one diagnostic method enough for hepatitis e diagnosis? | we assessed hepatitis e virus (hev) seroprevalence in patients with hepatic disorders as well as in human immunodeficiency virus (hiv)-infected patients and emphasised the issue of possible non-specific anti-hev seroresponse and need for combining diagnostic methods for hepatitis e diagnosis. over a two-year period, from march 2011 to february 2013, we determined anti-hev immunoglobulin m (igm) and igg by enzyme immunoassays (eia; mikrogen, germany) in 504 hepatitis patients negative for acute v ... | 2014 | 25005459 |
| [prokaryotic expression and characterization of truncated mutant capsid protein of genotype iv hepatitis e virus]. | a truncated mutant of the open reading frame 2 (orf2, aa384-606) was amplified from cdna of genotype iv hepatitis e virus (hev) by polymerase chain reaction (pcr), subcloned to expression plasmid pto-t7, and expressed in escherichia coli. sds-page and western blotting were used to detect and identify the recombinant protein, namely rp24. after washing of inclusion bodies, dissolving in denaturing agents, refoldeding by dialysis, ion exchange chromatography and gel chromatography, dynamic light s ... | 2014 | 25007574 |
| identification and characterization of avian hepatitis e virus in 2013 outbreaks of hepatitis-splenomegaly syndrome in two us layer operations. | two commercial midwestern egg-type chicken flocks experienced significant increases in mortality rates in april 2013 with clinical signs appearing in 17-week-old pullets on farm a and in 46-week-old hens on farm b. average weekly mortality was 0.44% over a 4-week period on farm a and 0.17% over an 8-week period on farm b. on farm a, flocks in the affected house had a 45% decrease in daily egg production from weeks 19 to 27 when compared with standard egg production curves (p < 0.01) while no dec ... | 2014 | 25010035 |
| comparison of three in-house elisas for the detection of hepatitis e virus infection in pigs under field conditions. | hepatitis e virus (hev) is a rna non-enveloped virus that comprises four genotypes. the genome of hev is organized into three open reading frames (orfs), and the orf2 is responsible for encoding capsid proteins. hev can infect a wide range of hosts, and pigs are considered the main reservoir. hev infection is considered a zoonosis and it is responsible for acute hepatitis in humans, especially in developing countries. the development of a blocking elisa would be of high value for screening purpo ... | 2014 | 25010789 |
| chronic hepatitis e virus infection following allogeneic hematopoietic stem cell transplantation: an important differential diagnosis for graft versus host disease. | 2015 | 25015055 | |
| acute hepatitis after starting pinaverium bromide in a patient taking mirtazapine. | a 56-year-old man presented with chronic abdominal pain. he had been evaluated extensively in the recent past undergoing upper gastrointestinal endoscopy, colonoscopy and ct scan of the abdomen with normal results. the provisional diagnosis of irritable bowel syndrome was performed and pinaverium bromide was started. the patient had pre-existing hypertension, a major depressive disorder and gastro-oesophageal reflux disease. he had been taking nebivolol and pantoprazole for several years and mir ... | 2014 | 25015163 |
| enteric porcine viruses in farmed shellfish in denmark. | bivalve shellfish are at constant risk of being exposed to pathogens as a consequence of contamination of the shellfish beds with human or animal waste originating from sewage treatment plants or slurry fertilized fields. consumption of contaminated oysters and mussels are frequently reported as causes of disease outbreaks caused by norovirus or hepatitis a virus. other zoonotic pathogens such as hepatitis e virus (hev), rotavirus (rv) and salmonella from livestock may also be transmitted to she ... | 2014 | 25016209 |
| hepatitis viruses and liver transplantation: evolving trends in antiviral management. | viral hepatitis is both a leading indication for liver transplant (lt) and an important cause of posttransplant graft loss and mortality. treatment and prevention of hepatitis b virus in lt recipients, with the observed corresponding improvement in post-lt outcomes, is among the great success stories in transplantation. by comparison, treatment of hepatitis c virus with safe and effective regimens is only just becoming a reality. chronic hepatitis e virus infection in lt recipients represents a ... | 2014 | 25017077 |
| hepatitis e virus in patients with acute severe liver injury. | to examine the incidence of hepatitis e (hepe) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit. | 2014 | 25018853 |
| seroprevalence study of hepatitis e virus infection in two districts of the czech republic. | the aim of this work was to retrospectively examine serum samples from 230 people living in two districts in the czech republic in year 1989 (znojmo and jihlava) for the igg antibodies against hepatitis e virus (hev). for examination, commercial elisa kit dia.pro was used and 13 seropositive persons were found, i.e. 5.7% of those examined. the seropositivity rate was higher in women (6.8%) than in men (3.7%), but the difference was not statistically significant. the age of examined persons did n ... | 2014 | 25025670 |
| rare case of transfusion-transmitted hepatitis e from the blood of a donor infected with the hepatitis e virus genotype 3 indigenous to japan: viral dynamics from onset to recovery. | the transfusion transmission of hepatitis e can occur even in non-endemic areas in the world as autochthonous hepatitis e has been increasingly reported in developed countries where the hepatitis e virus (hev) is not prevalent. we investigated the post-transfusion transmission of hepatitis e in a patient by molecularly confirming its presence, and characterized the viral kinetics of hev in this case. | 2015 | 25041213 |
| hepatitis e genotype 4 virus from feces of monkeys infected experimentally can be cultured in plc/prf/5 cells and upregulate host interferon-inducible genes. | the understanding of the interaction between hepatitis e virus (hev) and its host cells has been impeded greatly by the absence of a cell culture system. in this study, an efficient cultivation method was developed in plc/prf/5 cells for hev genotype 4 from the feces of monkeys infected experimentally. compared to minimal essential medium (mem), mixed dulbecco's modified eagle's medium (dmem)/m199 improved the infection efficiency of hev in plc/prf/5 cells. the incubation time and temperature we ... | 2014 | 25042677 |
| mtor-inhibitors may aggravate chronic hepatitis e. | 2014 | 25046849 | |
| hepeviridae: an expanding family of vertebrate viruses. | the hepatitis e virus (hev) was first identified in 1990, although hepatitis e-like diseases in humans have been recorded for a long time dating back to the 18th century. the hev genotypes 1-4 have been subsequently detected in human hepatitis e cases with different geographical distribution and different modes of transmission. genotypes 3 and 4 have been identified in parallel in pigs, wild boars and other animal species and their zoonotic potential has been confirmed. until 2010, these genotyp ... | 2014 | 25050488 |
| cirrhosis, liver transplantation and hiv infection are risk factors associated with hepatitis e virus infection. | acute and chronic hepatitis e have been associated with high mortality and development of cirrhosis, particularly in solid-organ recipients and patients infected by human immunodeficiency virus. however, data regarding the epidemiology of hepatitis e in special populations is still limited. | 2014 | 25068388 |
| hepatitis e virus infection in farmed rabbits and swine in the eastern chinese city lianyungang: showing no potential interspecies transmission. | rabbit hev isolated recently from farmed rabbits in china has been shown experimentally to be able to infect both cynomolgus macaques and pigs. the purpose of the present study was to investigate the extent to which cross-species transmission of rabbit hev in farm settings is a significant factor in the spread of this zoonotic infection. rabbit and swine feces were collected from the same area in eastern china (lianyungang city) and analyzed by rt-pcr. partial genome sequencing of a 365 bp regio ... | 2014 | 25069969 |
| hepatitis e virus in blood components: a prevalence and transmission study in southeast england. | the prevalence of hepatitis e virus (hev) genotype 3 infections in the english population (including blood donors) is unknown, but is probably widespread, and the virus has been detected in pooled plasma products. hev-infected donors have been retrospectively identified through investigation of reported cases of possible transfusion-transmitted hepatitis e. the frequency of hev transmission by transfusion and its outcome remains unknown. we report the prevalence of hev rna in blood donations, th ... | 2014 | 25078306 |
| novel molecular alterations in the orf 2 capsid gene of hepatitis e virus in patients with acute liver failure in north india. | hepatitis e virus (hev) is evolving as a major global threat to public health, including in developed countries. we partially sequenced the orf 2 capsid protein genes of hev genomes from patients with acute liver failure, including pregnant women in the northern part of india. five unique synonymous substitutions and one non-synonymous substitution, along with a novel mutation, p259s, in the capsid gene, were identified that might be associated with the poor outcome in the patients. phylogenetic ... | 2014 | 25100237 |
| characterization of the polyproline region of the hepatitis e virus in immunocompromised patients. | little is known about virus adaptation in immunocompromised patients with chronic genotype 3 hepatitis e virus (hev3) infections. virus-host recombinant strains have been isolated recently from chronically infected patients. the nature and incidence of such recombinant events occurring during infections of solid-organ transplant (sot) recipients are essentially unknown. the polyproline region (ppr) of strains isolated from sot patients was sequenced during the acute-infection phase (n = 59) and ... | 2014 | 25100839 |
| hepatitis e virus inhibits type i interferon induction by orf1 products. | hepatitis e virus (hev) causes both endemic and epidemic human hepatitis by fecal-oral transmission in many parts of the world. zoonotic transmission of hev from animals to humans has been reported. due to the lack of an efficient cell culture system, the molecular mechanisms of hev infection remain largely unknown. in this study, we found that hev replication in hepatoma cells inhibited poly(i·c)-induced beta interferon (ifn-β) expression and that the hev open reading frame 1 (orf1) product was ... | 2014 | 25100852 |
| evaluation of viral inactivation of pseudorabies virus, encephalomyocarditis virus, bovine viral diarrhea virus and porcine parvovirus in pancreatin of porcine origin. | pancreatin is a substance containing enzymes, principally amylase, lipase, and protease. it is obtained from bovine or porcine pancreas and used in the treatment of pancreatic endocrine insufficiency in humans. regulations and safety concerns mandate viral clearance (virus removal or inactivation) in biopharmaceuticals such as pancreatin. a virus validation study was performed to evaluate virus clearance achieved in the final step of drying under vacuum by testing a panel of four animal viruses: ... | 2014 | 25110118 |
| mode of swine hepatitis e virus infection and replication in primary human hepatocytes. | the aim of this study was to investigate the infection and replication of swine-derived hepatitis e virus (hev) in primary cultured human hepatocytes (phcs). hepatocytes were cultured from the resected normal livers of patients with metastatic tumours. these cultured hepatocytes were infected with swine-derived genotype 3 or 4 hev. viral replication was monitored using reverse transcriptase-quantitative pcr. the amount of hev rna increased in the culture media and cells following infection. immu ... | 2014 | 25114028 |
| safety measures to prevent hepatitis e virus transmission by blood transfusion. | 2014 | 25130335 | |
| acute fulminant hepatitis e virus genotype 3e infection: description of the first case in europe. | hepatitis e virus (hev) is the most important causative agent of acute hepatitis in developing countries. the disease is usually characterized by a self-limiting, benign course. however, when particular conditions coexist (pregnancy, old age, pre-existing liver disease) it may run an unfavourable course. to date, 4 hev genotypes have been described. historically, in the western world, hev infection was considered a travel-related disease, however in the last 2 decades a great number of non-trave ... | 2014 | 25134653 |
| crystal structure of a nematode-infecting virus. | orsay, the first virus discovered to naturally infect caenorhabditis elegans or any nematode, has a bipartite, positive-sense rna genome. sequence analyses show that orsay is related to nodaviruses, but molecular characterizations of orsay reveal several unique features, such as the expression of a capsid-δ fusion protein and the use of an atg-independent mechanism for translation initiation. here we report the crystal structure of an orsay virus-like particle assembled from recombinant capsid p ... | 2014 | 25136116 |
| early-life hepatitis e infection in pigs: the importance of maternally-derived antibodies. | passive immunity (pi), acquired through colostrum intake, is essential for piglet protection against pathogens. maternally-derived antibodies (mdas) can decrease the transmission of pathogens between individuals by reducing shedding from infected animals and/or susceptibility of naïve animals. only a limited number of studies, however, have been carried out to quantify the level of protection conferred by pi in terms of transmission. in the present study, an original modeling framework was desig ... | 2014 | 25144763 |
| clinical and molecular analyses of sporadic acute hepatitis a and e and the specific viral genotypes isolated in iwate and three neighboring prefectures in the northern part of honshu, japan, between 2004 and 2013. | to examine the prevalence and characteristics of hepatitis a virus (hav) and hepatitis e virus (hev) infections in the northern part of honshu, japan, during the last decade. | 2015 | 25146162 |
| decline in hepatitis e virus antibody prevalence in the united states from 1988-1994 to 2009-2010. | previous population-based estimates in the united states have shown a relatively high prevalence of hepatitis e virus (hev) antibody. we sought to determine whether changes in the prevalence of hev antibody have occurred over time. | 2015 | 25147277 |
| epidemiology of hepatitis e virus infection in patients on chronic hemodialysis. | many studies have been done on the epidemiology of hepatitis e on general population, but the data among patients with end stage renal disease (esrd) are few and give conflicting results. | 2014 | 25147715 |
| pork consumption and seroprevalence of hepatitis e virus,thailand, 2007-2008. | the nationwide seroprevalence of hepatitis e igg was determined among young men in thailand. overall seroprevalence was 14% (95% ci 13%-15%); range by province was 3%-26%. seroprevalence was lowest in the south, an area predominantly occupied by persons of the islam religion, whose dietary laws proscribe pork. | 2014 | 25148245 |
| hepatitis a and e seroprevalence and associated risk factors: a community-based cross-sectional survey in rural amazonia. | hepatitis a virus (hav) and hepatitis e virus (hev) are both transmitted by the faecal-oral route, and represent common causes of acute hepatitis in developing countries. the endemicity of hav infection has shifted from high to moderate in brazil. human cases of hev infection seem to be rare, although the virus has been detected in swine livestock and effluents of slaughterhouses. this study was to determine the epidemiology of hepatitis a and e in one of the largest agricultural settlements in ... | 2014 | 25149658 |
| hepatitis e virus: chronic infection, extra-hepatic manifestations, and treatment. | hepatitis e virus (hev) infection is a worldwide disease. an improved understanding of the natural history of hev infection has been achieved within the last decade. several reservoirs and transmission modes have been identified. it is an underdiagnosed disease because of the use of low-sensitivity serological assays; however, diagnostics tools, including nucleic-acid tests, have improved. hev infection is usually an acute self-limiting disease, but causes chronic infection with rapidly progress ... | 2015 | 25150374 |
| hepatitis e virus exposure in pregnant women in rural durango, mexico. | hepatitis e virus (hev) infection represents a risk for mortality in pregnant women. the seroepidemiology of hev infection in rural pregnant women in the americas is largely unknown. the aim of the study was to determine the seroepidemiology of anti-hev igg antibodies in rural pregnant women in durango, mexico. | 2015 | 25152983 |
| hepatitis e in australian hiv-infected patients: an under-recognised pathogen? | background hepatitis e virus (hev) infection has been found to cause chronic hepatitis in hiv-infected patients. in australia, where hev is nonendemic, background seroprevalence is reportedly low but has not been evaluated in the hiv-infected population. the study aimed to assess the seroprevalence of hev in a cohort of hiv-infected patients with normal liver function and in another group with biochemical hepatitis. | 2014 | 25162285 |
| seroprevalence of hepatitis e virus among pregnant women and control subjects in china. | hepatitis e infection, caused by the hepatitis e virus (hev), is an important global public health concern, with particularly high mortality in pregnant women. china is generally judged to be an hev-endemic area, but epidemiological data for hev among pregnant women are limited. between june 2011 and july 2013, a case-control study was conducted to estimate the seroprevalence and potential risk factors associated with the acquisition of hev infection by pregnant women in china. nine-hundred and ... | 2015 | 25164987 |
| detection of pathogenic viruses in sewage provided early warnings of hepatitis a virus and norovirus outbreaks. | most persons infected with enterically transmitted viruses shed large amounts of virus in feces for days or weeks, both before and after onset of symptoms. therefore, viruses causing gastroenteritis may be detected in wastewater, even if only a few persons are infected. in this study, the presence of eight pathogenic viruses (norovirus, astrovirus, rotavirus, adenovirus, aichi virus, parechovirus, hepatitis a virus [hav], and hepatitis e virus) was investigated in sewage to explore whether their ... | 2014 | 25172863 |
| changes in the cellular proteins of a549 infected with hepatitis e virus by proteomics analysis. | our understanding of hepatitis e virus (hev) has changed enormously over the past 30 years, from a waterborne infection causing outbreaks of acute hepatitis in developing countries to an infection of global distribution causing a range of hepatic and extra-hepatic illness. however, the key proteins playing important parts in the virus infection were still unknown. understanding the changes of cellular proteins in these cells exposed to hev is helpful for elucidating molecular mechanisms associat ... | 2014 | 25175408 |
| a mutation in the hepatitis e virus rna polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients. | we analyzed blood samples collected from 15 patients with chronic hepatitis e who were recipients of solid-organ transplants. all patients cleared the hepatitis e virus (hev) except for 2 (nonresponders); 1 patient died. a g1634r mutation in viral polymerase was detected in the hev rna of the nonresponders; this mutation did not provide the virus with resistance to ribavirin in vitro. however, the mutant form of a subgenomic replicon of genotype 3 hev replicated more efficiently in vitro than he ... | 2014 | 25181691 |
| clinical profile, maternal and fetal outcomes of acute hepatitis e in pregnancy. | pregnant women are at increased risk of complications in hepatitis e virus (hev) infection, with the risk increasing as the pregnancy progresses, often leading to fulminant hepatic failure and adverse fetal outcome. | 2014 | 25184080 |
| genetic heterogeneity of swine hepatitis e virus isolates from yunnan province, china in 2011-2012. | hepatitis e is a disease of major public-health concern mainly in developing countries. although molecular and sero-epidemiological investigations of hev have been performed in many provinces in china, the epidemiological data from yunnan province are limited and genotypes are not be fully characterized. in this study the prevalence and characteristics of hepatitis e virus (hev) detected in pigs from yunnan province, china was evaluated. | 2014 | 25187005 |
| hepatitis e virus of subtype 3i in chronically infected kidney transplant recipients in southeastern france. | hepatitis e virus (hev) is a leading cause of waterborne acute hepatitis in developing countries. in europe, hev causes a zoonotic disease and is hyperendemic in southern france. four hev genotypes (1 to 4) have been defined, and the most used classification divides them into 24 subtypes. autochthonous european hev strains belong in majority to genotype 3. subtypes 3c, 3f, and 3e are representative of the hev diversity in france. hev causes chronic hepatitis in solid-organ transplant recipients ... | 2014 | 25187634 |
| meeting report: 2013 pda virus & tse safety forum. | the report provides a summary of the presentations and discussions at the virus & tse safety forum 2013 organized by the parenteral drug association (pda) and held in berlin, germany, from june 4 to 6, 2013. the conference was accompanied by a workshop, "virus spike preparations and virus removal by filtration: new trends and developments". the presentations and the discussion at the workshop are summarized in a separate report that will be published in this issue of the journal as well. as with ... | 2016 | 25188343 |
| a hospital-based retrospective study on frequency and distribution of viral hepatitis. | viral hepatitis is a major public health problem throughout the world. it is the inflammation of the liver due to the infection of any of the five main hepatic viruses a to e and it affects the liver through different modes of transmission. this study mainly aims at the frequency and distribution of viral hepatitis based on age and sex during a time period of 5 years. | 2014 | 25191049 |
| the impact of hepatitis e in the liver transplant setting. | hepatitis e virus (hev) infection has been identified as a cause of graft hepatitis in liver transplant recipients. the true frequency and clinical importance of hev infections after liver transplantations is a matter of debate. it is proposed that consumption of hev-contaminated undercooked meat is a main source for hev infections in developed countries--which might also account for some hepatitis e cases after organ transplantation. however, hev is also transmitted by transfusion of blood prod ... | 2014 | 25195557 |
| a population-based seroepidemiological study on hepatitis e virus in iran. | background little is known about hev seroprevalence and its determinants in iran. considering the fact that iran is among the countries in which hev infection is endemic, a large-scale population-based study in this regard is justified. methods this survey was conducted in 2006 in tehran and golestan provinces, iran. stored sera of subjects were tested for serological markers of anti-hev. the baseline data were recorded in structured questionnaires. weighted seroprevalence and weighted logistic ... | 2010 | 25197520 |
| reply to "does chronic hepatitis e virus infection exist in immunocompetent patients?". | 2015 | 25203636 | |
| [serum anti-hepatitis e virus igg antibody and risk factors among female residents of xinmi in henan province]. | to determine the distribution of anti-hepatitis e virus (hev) igg antibody and anti-human papilloma virus (hpv) igg antibody among female residents of xinmi and investigate the risk factors of hev infection. | 2014 | 25203701 |
| [construction and investigation of a recombinant eukaryotic expression vector for expressing the orf3 protein of hepatitis e virus in bhk-21 fibroblasts]. | to construct a eukaryotic expression vector to express the hepatitis e virus protein open reading frame 3 (orf3) and investigate the intracellular location of the expressed protein using the baby hamster kidney (bhk-21) fibroblast cell line. | 2014 | 25203800 |
| identification of an antigenic domain in the n-terminal region of avian hepatitis e virus (hev) capsid protein that is not common to swine and human hevs. | the antigenic domains located in the c-terminal 268 amino acid residues of avian hepatitis e virus (hev) capsid protein have been characterized. this region shares common epitopes with swine and human hevs. however, epitopes in the n-terminal 338 amino acid residues have never been reported. in this study, an antigenic domain located between amino acids 23 and 85 was identified by indirect elisa using the truncated recombinant capsid proteins as coating antigens and anti-avian hev chicken sera a ... | 2014 | 25209807 |
| first detection of hepatitis e virus in central argentina: environmental and serological survey. | the hepatitis e virus (hev) is an emergent causative agent of acute hepatitis worldwide, transmitted by fecal-oral route. in argentina it is considered rare, so differential laboratory testing is not routinely performed. besides, in argentina's central area epidemiological and molecular characteristics of hev are still unknown. | 2014 | 25213209 |
| seroprevalence of hepatitis e virus infection in psychiatric patients and control subjects in shandong province, eastern china. | hepatitis e, caused by the hepatitis e virus (hev), is an important global public health concern. there are conflicting reports in regard to the association of hev infection and psychiatric disorders. therefore, we investigated this association in a chinese population through a case-control seroprevalence study. | 2014 | 25220239 |
| [feasibility of hev vaccine as control in hpv vaccine study and comparison of serological and risk factors between hev and hpv infection among females]. | investigating the distribution of anti-hepatitis e virus (hev-igg), anti-human papillomavirus (hpv l1-igg) and risk factors among female residents in xinmi county, to explore the influencing factors of hpv vaccine study using hev vaccinated population as a control. | 2014 | 25241795 |