Publications

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immunochemical studies on salmonella typhi. 3. fractionation of polysaccharides from typhoid bacilli r forms with cetyltrimethylammonium bromide "cetavlon". 19665959480
[quantitative test of sensitivity to chloramphenicol of typhoid and paratyphoid salmonellae]. 19665961222
transfer of the immunization to a bacterial antigen by rna. 19665970607
[effect exercised in vitro by a fraction of histones on intracellular death, after phagocytosis, of different bacteria]. 19665972278
[the rough granular endotoxins: toxic properties]. 19665973019
[on various lysotypes of salmonella typhi and salmonella paratyphi b detected recently in rumania]. 19665973707
chloramphenicol resistance of salmonella typhi and salmonella paratyphi a isolated during 1962-1965. 19665976562
chemical prevention of radiation-induced leukemia in mice. 19665980567
[the complementary bacteriophage typing of s. typhi lysotype a. preliminary note]. 19665983324
[the subdivision of lysotype f1. experiences and epidemiological importance]. 19665983616
[studies on the modifications of s. typhi in the process of lysogenization under the action of heterologous phages]. 19665985355
[lyophilization of the salmonella typhi bacteriophage vi ii]. 19665985357
[observations on bacteriophage typing of s. typhi strains belonging to phage group d]. 19665985359
the demonstration of the toxicity of vi-antigen on cell cultures and suspensions. 19665985367
[decontamination of sewage containing the causative agent of abdominal typhus in experimental underground filtration installations]. 19665988751
[on the stability of lysotypes of salmonella typhi in carriers]. 19665990064
[some remarks on the presence of antagonists to typhus bacilli on the surface of articles of food]. 19665991161
[studies on the stability of the properties of lyophilically dried microbes during long storage]. 19665993612
[report on 300 cholecystectomies with special reference to preoperative diagnosis bacteriological and histological findings]. 19665994171
[distribution of lysotypes of s. typhi and s. paratyphi b in the federal republic of germany in the years 1958 to 1961]. 19665996405
[drug polyresistance in typhoid bacteria and their genetic prerequisites]. 19665996875
[test of the development of resistance to some antibiotics in typhoid bacteria]. 19665997597
[peculiarities of the course of typhoid diseases in immunized persons]. 19665999464
[changes in the activity of decarboxylase amino acids of typhoid bacteria in the process of developing resistance toward antibiotics]. 19665999794
[recurring typhoid fever]. 19666001231
[hemorrhagic manifestations in pneumonia associated with shwartzman hyperergic phenomenon]. 19666001804
[detection of cells forming antibodies to the o-antigen of s. typhi by the method of local passive hemolysis in agar]. 19666002383
[the effectiveness of vaccinating 3 to 7 year old children against typhoid fever with a purified preparation of s. typhi vi-antigen (based on data from a controlled epidemiologic trial)]. 19666003713
[comparative study of the immunologic indices of rabbits immunized with typhoid culture and alcohol monovaccine]. 19666003716
[sensitivity of typhoid fever cultures to bacteriophages]. 19666003865
[synchronization of the fission of typhoid bacteria by dilution of the culture with fresh nutrient medium]. 19666004604
[filterable forms of bacteria isolated from the blood of typhoid patients]. 19666004898
[lysogenicity of typhoid bacteria]. 19666005078
febrile responses of rabbits to bacterial endotoxin following incubation in homologous serum and plasma. 19676017781
the effect of 7s and 19s antibodies on the primary response to salmonella typhi antigens. 19676020396
ampicillin "penbritin" in the treatment of acute brucella melitensis septicaemia and salmonella typhi urinary carriers. 19676022422
neonatal cortisol administration and immunological impairment in the adult rat. 19676023411
increased resistance to endotoxin in germ-free guinea pigs. 19676024851
typhoid osteomyelitis of the calcaneus due to direct inoculation. 19676026006
appraisal of typhoid vaccine in experimentally infected human subjects. 19676028241
endotoxin-induced wasting disease in mice: a temporary condition explained by endotoxin tolerance. 19676028571
effect of phytohemagglutinin (pha) on an antibody-forming system. 19676029275
the antibody response in nasal washings and serum to s. typhosa endotoxin administered intravenously. 19676029280
nitrofuryl heterocycles. v. 4-acyl-5,5-dialkyl-2-(5-nitro-2-furyl)-delta-1,3,4-oxadiazolines. 19676031710
induction of histamine forming capacity in canine liver by endotoxin. 19676033329
changes in the sensitivity of x-irradiated mice to bacterial endotoxin. 19676035161
electron microscopy of the combination of antibodies with flagellar antigen and with a pyocine.micrographs are presented of antibodies in combination with flagella of salmonella typhi and with a phage-bound pyocine rmc, which is supposed to be the tail of a defective bacteriophage from pseudomonas aeruginosa. the pyocine preparation seems to offer advantages for the study of antibody-antigen complexes. under the conditions of our experiments, the surfaces of the antigenic structures are saturated with antibody layers approximately 95 a in thickness, i.e., slightly less than half the accep ...19676035268
isolation of salmonella typhi from uncommon sites. 19676036500
the antigenic activity of native and heat-denatured dna isolated from salmonella typhi strain ty2. 19676036849
[bacilli of the salmonella group in city sewage]. 19676044687
changes in the serum lipid fractions of cholesterol-fed and control rabbits induced by salmonella typhi endotoxin. 19676052601
[effects of a histone fraction (p ii) on the bactericidal potency of a leukocyte extract and guinea pig serums]. 19676055849
[effect of lyophilization on the vi lysotypes of salmonella typhi]. 19676055854
the pyrogenic effect of scarlet fever toxin. 3. the effect of cortisone on the pyrogenic, lethal and dermal activity of scarlet fever toxin. 19676056768
[water bactericidal activity and the part played by bdellovibrio bacteriovorus]. 19676057341
[the isoelectric points of ribonucleoproteins in lymph node cells during immunogenesis]. 19676064893
salmonella typhi pneumonia without intestinal lesions. 19676066491
bearers of bacterial burdens. 19676071416
effectiveness of high ph for destruction of pathogens in raw sludge filter cake. 19676074492
[enzymatic modifications observed in the testicles of guinea pigs and rats poisoned by a bacterial endotoxin]. 19676076178
[effect of chloramphenicol on the resistivity reaction in rat]. 19676078340
[isolation of salmonella typhi strain showing atypical growth in tsi media]. 19676079039
[nucleic acids in lymphocytes during the formation of plasma and cellular antibodies]. 19676079894
[studies of strain-specific differences in the resistance of salmonella typhi to the effects of anion detergents and heat]. 19676080970
the integrity of the endotoxin tolerance mechanisms during typhoid fever in man. 19676082245
[immunochemical characteristics of artificial antigens with salmonella o-determinants 4 and 9].two new synthetic high-molecular protein-free o-antigens have been obtained. these o-antigens are copolymers of synthetic disaccharides with acrylamide. the copolymers of alpha-allylglycosides, abequosyl-(alpha 1----3]-mannopyranose and tyvelosyl-(alpha 1----3)-mannopyranose, with acrylamide have been shown to possess, respectively, the specificity of immunodominant o-factors 4 and 9 characteristic of salmonella serogroups b and d1. the synthetic o-antigens have proved to possess higher capacity ...19846084378
the hemolytic effect of salmonella typhi ty 2 porins.two outer membrane proteins of salmonella typhi ty 2 were extensively co-purified. according to their migration in dodecylsulfate/polyacrylamide gel electrophoresis and solubility characteristics, these proteins are homologous to the 35-kda and 36-kda porins found in salmonella typhimurium. a porin homologous to the 34-kda one has not been found in s. typhi ty 2. a critical step in the purification of porins is heating at 100 degrees c in 2% sodium dodecyl sulfate before sephadex gel filtration. ...19846086333
comparative study of three blood culture systems for isolation of enteric fever salmonella.eight hundred blood cultures were tested in parallel in three conventional systems: tryptic soy broth containing 0.05% sodium polyanethosulfonate (tsb-sps), whole blood in bile (bile-blood), and blood clots in bile (bile-clot). sixty-eight cultures were salmonella typhi positive and 29 were positive for s. paratyphi a in at least one of the systems. analysis of the isolation rates of the 97 salmonella-positive specimens showed that bile-blood was significantly more sensitive (p less than 0.05) t ...19846095460
comparative biochemical studies on f and edp208 conjugative pili.edp208 pili are encoded by a derepressed derivative of a naturally occurring lac plasmid, f(0)lac (incompatibility group fv), originally isolated from salmonella typhi. edp208 pili are serologically unrelated to f pili and do not promote infection by f-specific ribonucleic acid bacteriophages. however, they do confer sensitivity to the f-specific filamentous deoxyribonucleic acid phages. edp208-containing cells are multi-piliated and contain approximately 20 pili per cell. these pili contain a s ...19806101592
new method for serological screening of typhoid carriers. 19806106808
vi serology in the detection of typhoid carriers.a new haemagglutination assay for vi antibodies was evaluated in searches for symptom-free carriers of salmonella typhi associated with sporadic cases of typhoid fever. the assay differs from previous ones in that a purified (instead of crude) vi antigen from citrobacter was used to sensitise the red blood cells. in ten sporadic outbreaks of typhoid stool culture identified seven enteric carriers of s. typhi among the patients' families or other close contacts. all seven carriers had vi antibodi ...19816110821
salmonella typhi in vivo acquires resistance to both chloramphenicol and co-trimoxazole.salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. chloramphenicol and sulphonamide resistances were determined by one plasmid, of inch, whose carriage also changed the vi phage type. trimethoprim resistance was determined by a transposon, tn7, carried in another plasmid, of inci. the same resistance genes were identified in a strain of klebsiella isolated from the patient.19816112529
acquisition of resistance by salmonella typhi in vivo. 19816113504
plasmid-mediated multidrug resistance in salmonella typhi. 19816115137
acquisition of resistance by salmonella typhi in vivo: the importance of plasmid characterisation. 19826122032
chloramphenicol-resistant salmonella typhi vi phage type a isolated from patient in bangladesh. 19826122918
chloramphenicol resistance in salmonella typhi. 19826124832
chloramphenicol resistance in salmonella typhi. 19826125791
incidence of trimethoprim resistance in salmonellae isolated in britain: a twelve year study. 19826126637
oral typhoid vaccine ty21a. 19836131224
incubation period and other features of food-borne and water-borne outbreaks of typhoid fever in relation to pathogenesis and genetics of resistance.examination of the incubation period of typhoid fever, the attack rate, and the spread of the case-onset pattern in food-borne and water-borne outbreaks and in experimental infections indicates that typhoid fever arises when organisms invade the circulation by at least two mechanisms--as a result of either the net growth of invading organisms at an early stage or a breakdown in host cellular mechanisms later. the distribution of case-onset patterns suggests that a small number of genes, possibly ...19836132187
a rare cause of cholecystitis in pregnancy.a case of typhoid cholecystitis presenting in pregnancy with acute symptoms and signs is reported. the patient failed to respond adequately to conservative treatment, and surgical intervention was required. the outcome of the pregnancy was satisfactory. the management of such a case is discussed.19836136440
travellers' diarrhoea: prospects for successful immunoprophylaxis.enterotoxigenic escherichia coli (etec) are the major aetiological agent of travellers' diarrhoea, usually accounting for 30-60% of cases. thus a safe and effective vaccine against etec could play an important role in prevention of this infection. a successful vaccine must somehow protect against a heterogenous array of etec pathogens comprising many o:h serotypes and three enterotoxin phenotypes (lt+/st-, lt-/st+, and lt+/st+). three major approaches to vaccine development are currently in prog ...19836138855
rapid diagnosis of typhoid fever by antigen detection.salmonella typhi antigen was demonstrated in the blood of patients with typhoid fever by a passive staphylococcal agglutination test. this test was positive in 10 culture-proven typhoid patients and negative in 10 febrile patients without typhoid.19846140444
enzyme-linked immunosorbent assay with a monoclonal antibody for detecting group a meningococcal antigens in cerebrospinal fluid.hybridomas were produced from spleen cells of balb/c mice immunized with a membrane preparation from neisseria meningitidis group a strain 4402 and s194/5.xxobu.14 myeloma cells. the hybridomas were screened for secretion of antibodies suitable for an enzyme-linked immunosorbent assay (elisa) diagnostic for group a meningococcal meningitis. one hybridoma antibody, 3g7, was directed against the pilus protein. this antibody bound to all six lipopolysaccharide and protein group a meningococcal sero ...19846142055
recent advances in salmonellosis treatment based on in vitro susceptibilities.chloramphenicol-resistant strains of salmonella typhi (mic 60 micrograms/ml), chloramphenicol and ampicillin-resistant strains of salmonella typhimurium as well as multiresistant strains of various salmonella serotypes were found to be very sensitive to cephradine (mic 0.078-0.625 micrograms/ml). ten patients with salmonella typhi bacteremia were successfully treated with cephradine; all the patients' strains were chloramphenicol-resistant. cephradine appears to warrant further clinical trial fo ...19806152997
mechanisms of antigen-induced blockade of immune response and cyclophosphamide-promoted tolerance to salmonella typhi vi antigen.blockade of the immune response, caused by a high dose of salmonella typhi vi antigen (200 microgram i.v.) and cyclophosphamide (cy)-induced tolerance to vi antigen, were analyzed. the results of the study show that blockade of the immune response cannot be attributed to masking of the response resulting from neutralization of antibodies by the excess of non-cell-bound antigen. a high dose of vi-antigen induced triggering and proliferation of specific b precursors but reversibly suppressed synth ...19806156850
the effect of adding iron to mucin on the enhancement of virulence for mice of salmonella typhi strain ty 2. 19806156943
stimulation of prostaglandin e production by bacterial endotoxins in cultured human synovial fibroblasts.e coli, shigella, salmonella, and cholera endotoxins stimulated prostaglandin e (pge) production by cultured human synovial and foreskin fibroblasts. the minimal effective dose of shigella endotoxin was 2 micrograms/ml and a maximal response was observed at 10 micrograms/ml. pge stimulation was first detected 7 hours after addition of cholera endotoxin. stimulation by shigella endotoxin of both pge and hyaluronic acid production was inhibited by indomethacin and aspirin. the present results sugg ...19806157394
quantitative immunoelectrophoretic analysis of salmonella typhi antigens and of corresponding antibodies in human sera.by quantitative immunoelectrophoretic methods, 86 different antigens were found in sonicated preparations of a salmonella typhi, using corresponding rabbit antiserum. lipopolysaccharide was identified, and 5 other antigens characterized. antibodies against a total of 19 s. typhi antigens were found in human sera. the antibody response in patients with typhoid fever was significantly more pronounced compared to that in normal persons. when the antibody response was expressed as a precipitin score ...19806158255
[effect of different factors on the induction of mimicry antigens of typhoid bacteria].the in vitro and in vivo (white mice) studies have shown that female sex hormones, especially folliculin and hexestrol, as well as the deficiency of the t-lymphoid system of the organism in which the microbe is circulating, and also some microbial cell components accelerate the synthesis of s. typhi antigens serologically similar to the antigens of the microorganism. antibiotics, especially oxacillin and ampicillin, sulfa drugs, especially sulfadimethoxine, inhibit antigenic mimicry in s. typhi. ...19806159751
genetic regulation of variable vi antigen expression in a strain of citrobacter freundii.certain strains of the genus citrobacter exhibit a variable expression of the vi surface antigen that appears to involve a special mechanism for regulation of gene expression. two nonlinked chromosomal loci, viaa and viab, are known to determine nonvariable vi antigen expression in strains of salmonella. to confirm the presence of analogous loci in citrobacter and to ascertain whether either of them is involved in variable vi antigen expression in this organism, donor strains were constructed fr ...19816161917
immunochemical properties of vi antigen from salmonella typhi ty2: presence of two antigenic determinants.antigen vi of salmonella typhi was found to have at least two antigenic determinants. in one of them, o-acetyl moiety played a dominant role. the second antigenic determinant did not involve o-acetyl residues, but both carboxyl and n-acetyl groups were necessary for the antigen-antibody reaction. these results were obtained by performing serological tests with antigen vi, with its structural analog, polygalacturonic acid, and with the derivatives of both polysaccharides.19806163712
diversity of vi-related antigens in the microcapsule of salmonella typhi.two new antigenic acidic polysaccharides, vi-p and vi-c, were isolated from the microcapsule of salmonella typhi by a very mild procedure. the antigens were purified to serological homogeneity, and it was found that each of them shares with vi antigen one of its two serological determinants (a different one in each case). one of the antigens vi-c, was also isolated from escherichia coli b, which is not a vi-producing strain.19806164644
[serological activity of salmonellal h antigen in the enzyme-labeled antibody reaction]. 19816170798
[anti-antibodies. iii. comparative characteristics of anti-antibodies obtained by different methods]. 19816171955
construction of a potential bivalent vaccine strain: introduction of shigella sonnei form i antigen genes into the gale salmonella typhi ty21a typhoid vaccine strain.shigella sonnei, an intestinal pathogen, produces a characteristic form i cell surface antigen now known to be plasmid encoded. we considered that the gale salmonella typhi ty21a oral vaccine strain, highly effective against typhoid, might be modified so as to be protective also against shigellosis due to s. sonnei. the plasmid responsible for form i antigen synthesis was therefore conjugally transferred to the gale s. typhi strain. serological studies revealed that the derivative strain produce ...19816174449
specificity of lymphocyte stimulation in vitro by microbial preparations: importance of antigen concentration.blood mononuclear cells were stimulated in vitro by 7 different microbial preparations, and thymidine incorporation was investigated in 7 groups of persons sensitized to the microorganisms and in 7 groups of controls. the sensitized persons were: 18 bcg-vaccinated, 13 with previous mycoplasma pneumoniae pneumonia, 22 who had serum antibodies to herpes simplex virus, 14 with previous typhoid fever, 13 with previous acute pyelonephritis caused by eschrerichia coli, 6 with previous haemophilus infl ...19816175167
a comparative study of gastric mucin and commercial baker's yeast as virulence-enhancing agents in the typhoid mouse protection test. 19826175648
polysaccharides and their common proteinic carrier in the vi antigens of citrobacter ballerup and salmonella typhi ty2.immunochemical analysis of citrobacter ballerup and salmonella typhi ty2 showed that the strains share native and heat-resistant proteins that are, apparently, the carriers of a common polysaccharidic determinant present in their respective somatic antigens. after the classic acetic acid hydrolysis, the somatic antigen of c. ballerup reacted, in agar gel, against the homologous antiserum by two precipitation lines, one of which also precipitated against the anti s, typhi ty2 serum; the hydrolysi ...19816176838
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