Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| computer-assisted image analysis of small cell lymphoma of the thyroid gland. comparison of nuclear parameters of small lymphocytes in lymphomas and hashimoto's thyroiditis. | the nuclear parameters of the small lymphocytes in nine cases of small cell lymphomas of the thyroid gland and 17 cases of hashimoto's thyroiditis were assessed by computer-assisted image analysis. the nuclear area, maximal, minimal and averaged ferret diameters, perimeter, regularity factor and elongation factor were gauged. statistically, the nuclear area was ascertained to be the optimum descriptor discriminating between small neoplastic and reactive lymphocytes. application of a novel variab ... | 1998 | 10098895 |
| role of a novel kca opener in regulating k+ channels of hypoxic human pulmonary vascular cells. | hypoxic pulmonary vasoconstriction (hpvc) is mediated, in part, via membrane depolarization and inhibition of k+ channels. we recently observed that the naturally occurring steroid dehydroepiandrosterone (dhea) reversed and prevented hpvc in isolated perfused and ventilated ferret lungs. in the current study, we investigated the effects of dhea on the major k+ channels of chronically hypoxic human pulmonary smooth-muscle cells (hpsmc). k+ channels were recorded by using the patch-clamp technique ... | 1999 | 10101006 |
| distinct transient outward potassium current (ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. | the biophysical characteristics and alpha subunits underlying calcium-independent transient outward potassium current (ito) phenotypes expressed in ferret left ventricular epicardial (lv epi) and endocardial (lv endo) myocytes were analyzed using patch clamp, fluorescent in situ hybridization (fish), and immunofluorescent (if) techniques. two distinct ito phenotypes were measured (21-22 degrees c) in the majority of lv epi and lv endo myocytes studied. the two ito phenotypes displayed marked dif ... | 1999 | 10102938 |
| spatiotemporal patterning of glutamate receptors in developing ferret striate cortex. | we have studied glutamate receptor levels during very early phases of cortical formation by using quantitative in vitro autoradiography to map the expression of nmda, ampa and kainate receptors in the developing primary visual cortex of the ferret. nmda and non-nmda receptors exhibit very different developmental profiles in primary visual cortex. nmda receptor density is low at birth and increases throughout the first 2 postnatal months, rising between threefold (layers ii/iii) and ninefold (lay ... | 1999 | 10103086 |
| undercover 'shopping' to evaluate lab services. | wonder what goes on at your outpatient labs when you're not there? this clever adaptation from the retail world can help you ferret out foul play and affirm first-rate employees. | 1993 | 10126796 |
| evaluating a practice opportunity. asking the right questions. | as a candidate for a position, your job is to identify the expectations of physicians, why previous administrators have failed to meet these expectations and the limits within which a new administrator can operate. most groups that approach experienced administrators with the prospect of future employment have already lost their administrator, either through a forced termination or the administrator's voluntary move. administrators who do not adequately evaluate the opportunity usually receive t ... | 1995 | 10155933 |
| neuronal nitric oxide facilitates vagal chronotropic and dromotropic actions on the heart. | previous studies, using non-specific nitric oxide synthase (nos) inhibitors, have shown that nitric oxide (no) has a significant facilitatory effect on the actions of the vagus nerve on several aspects of cardiac function. the present study aims to identify a potential neuronal site for the action of no by using the n-nos inhibitor, 1-(2-trifluoromethylphenyl) imidazole (trim) in the ferret and other mammals. the effects of trim on vagally evoked alterations in heart rate and atrio-ventricular ( ... | 1999 | 10189115 |
| recombinant influenza a virus vaccines for the pathogenic human a/hong kong/97 (h5n1) viruses. | recombinant reassortment technology was used to prepare h5n1 influenza vaccine strains containing a modified hemagglutinin (ha) gene and neuraminidase gene from the a/hong kong/156/97 and a/hong kong/483/97 isolates and the internal genes from the attenuated cold-adapted a/ann arbor/6/60 influenza virus strain. the ha cleavage site (ha1/ha2) of each h5n1 isolate was modified to resemble that of "low-pathogenic" avian strains. five of 6 basic amino acids at the cleavage site were deleted, and a t ... | 1999 | 10191214 |
| coronary microvascular protection with mg2+: effects on intracellular calcium regulation and vascular function. | the use of mg2+-supplemented hyperkalemic cardioplegia preserves microvascular function. however, the mechanism of this beneficial action remains to be elucidated. we investigated the effects of mg2+ supplementation on the regulation of intracellular calcium concentration ([ca2+]i) and vascular function using an in vitro microvascular model. ferret coronary arterioles (80-150 micrometer in diameter) were studied in a pressurized (40 mmhg) no-flow, normothermic (37 degrees c) state. simultaneous ... | 1999 | 10199833 |
| development and organization of ocular dominance bands in primary visual cortex of the sable ferret. | thalamocortical afferents in the visual cortex of the adult sable ferret are segregated into eye-specific ocular dominance bands. the development of ocular dominance bands was studied by transneuronal labeling of the visual cortices of ferret kits between the ages of postnatal day 28 (p28) and p81 after intravitreous injections of either tritiated proline or wheat germ agglutinin-horseradish peroxidase. laminar specificity was evident in the youngest animals studied and was similar to that in th ... | 1999 | 10213088 |
| pseudomonas aeruginosa alginate is a potent secretagogue in the isolated ferret trachea. | airway mucus hypersecretion is in part a response to infection and inflammation. pseudomonas aeruginosa infection is nearly universal in advanced cystic fibrosis (cf) lung disease. mucoid strains of p. aeruginosa produce an exopolysaccharide product called alginate. the purpose of this study was to determine whether p. aeruginosa alginate stimulates secretion from mucous or serous cells in the ferret trachea exposed to alginate at concentrations reported to be present in the cf airway. we used a ... | 1999 | 10213255 |
| anti-emetic effects of a novel nk-1 receptor antagonist hsp-117 in ferrets. | we have developed a non-peptide compound, hsp-117, antagonist of the tachykinin nk-1 receptor. binding of 3h-substance p (sp) to the membranes of im-9 cells was inhibited by the antagonists hsp-117 and cp-99,994, the inhibitory activity of hsp-117 being about 50-fold that of cp-99,994. the sp-induced firing responses of single neuron activity in slices of the nucleus tractus solitarius of ferrets were inhibited by 10 microm hsp-117. intracerebroventricular injection of hsp-117 significantly inhi ... | 1998 | 10214984 |
| chloride transport in the ferret trachea. | a net secretion of chloride stimulated by carbamylcholine was observed in whole trachea. luminal anthracene-9-carboxylic acid inhibited the net secretion of chloride and the transepithelial potential difference across the isolated trachea. submucosal ouabain inhibited the net secretion of chloride and submucosal ouabain, or submucosal bumetanide inhibited the transepithelial potential difference across the isolated trachea. short-circuited flat sheets of trachea manifested a net secretion of chl ... | 1999 | 10216934 |
| emesis induced by inhibitors of type iv cyclic nucleotide phosphodiesterase (pde iv) in the ferret. | emesis induced by inhibitors of type iv cyclic nucleotide phosphodiesterase (pde iv) has been investigated in the ferret. the pde iv inhibitors studied were: rs14203, r-rolipram and ct-2450 (i.e. (r)-n-[4-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(4-pyridyl)ethyl]phenyl ]n'-ethylurea), in addition to the less active enantiomers s-rolipram and ct-3405. following oral administrations, different emetic profiles were observed with time. emesis induced by rs14203 exhibited a dose-response relationship ... | 1999 | 10218871 |
| interference with the development of early generated neocortex results in disruption of radial glia and abnormal formation of neocortical layers. | early generated layers of neocortex are important factors in forming the subsequent architecture of the cerebral cortex. to further explore the role of early generated cortex, we disrupted formation of an early generated cohort of cells by intraperitoneal injections of the mitotic inhibitor methylazoxymethanol (mam) into pregnant ferrets timed to coincide with generation of subplate neurons in the ventricular zone. our studies demonstrate that if early development of the neocortex is interrupted ... | 1999 | 10220225 |
| a novel mammalian cell (vero) derived influenza virus vaccine: development, characterization and industrial scale production. | influenza virus for vaccine production are presently produced in embryonated chicken eggs. this conventional standard methodology is extremely cumbersome; it requires a huge amount of eggs and an extensive purification to reduce the amount of contaminating egg proteins and to minimize the risk of allergies against egg albumin. the shortage of eggs in a pandemic situation, the selection of egg-adapted variants and the presence of adventitious viruses has emphasized the necessity for production of ... | 1999 | 10226351 |
| intracellular survival of virulent mycobacterium bovis and m. bovis bcg in ferret macrophages. | the intracellular survival of virulent mycobacterium bovis and avirulent m. bovis bcg in ferret alveolar macrophages was investigated. in addition, the effects of endogenous and exogenous modulators of macrophage oxidative function on bacterial survival and growth in vitro were determined. ferret macrophages limited the initial growth of bcg, while virulent m. bovis replicated within macrophages. intracellular bacterial survival was unaffected by the addition of specific inhibitors of macrophage ... | 1999 | 10227125 |
| the value of histomorphometric nuclear parameters in the diagnosis of well differentiated follicular carcinomas and follicular adenomas of the thyroid gland. | to explore the potential of histomorphometric analysis in distinction between follicular adenomas and well differentiated follicular carcinomas of the thyroid gland. their differentiation on routine histological study may be a challenging exercise, being contingent upon the absence or presence of vascular invasion and penetration of neoplastic follicles through the capsule of the tumour. | 1999 | 10231421 |
| the vomeronasal organ of the male ferret. | the vomeronasal organ (vno) is known to play a major role in sexual behavior in many mammals. this study is the first report that the adult male ferret has a vno, which is considerably smaller and morphologically different from the usually crescent-shaped epithelium in several mammalian species, particularly rodents. there were no differences in the size or structure of the ferret vno between the mating season in spring and the sexually quiescent season in autumn, although plasma testosterone, t ... | 1999 | 10321813 |
| enhanced nr2a subunit expression and decreased nmda receptor decay time at the onset of ocular dominance plasticity in the ferret. | enhanced nr2a subunit expression and decreased nmda receptor decay time at the onset of ocular dominance plasticity in the ferret. the nmda subtype of glutamate receptor is known to exhibit marked changes in subunit composition and functional properties during neural development. the prevailing idea is that nmda receptor-mediated synaptic responses decrease in duration after the peak of cortical plasticity in rodents. accordingly, it is believed that shortening of the nmda receptor-mediated curr ... | 1999 | 10322092 |
| 5-ht3 receptor antagonists ameliorate emesis in the ferret evoked by neutron or proton radiation. | nausea and vomiting produced by sub-lethal doses of x- or gamma-rays can be ameliorated by serotonin subtype-three (5-hydroxytryptamine; 5-ht3) receptor antagonists. the effectiveness of these anti-emetics on blocking the emetic responses induced by fission neutron or proton radiation exposure was evaluated in the ferret animal model. | 1999 | 10332945 |
| transneuronal tracing of neural pathways controlling activity of diaphragm motoneurons in the ferret. | previous studies have shown that neurons in addition to those in the medullary respiratory groups are involved in activating phrenic motoneurons during a number of behaviors, including vomiting and reaction to vestibular stimulation. however, the location of premotor inspiratory neurons outside of the main medullary respiratory groups is largely unknown, particularly in emetic species. in the present study, the transneuronal tracer pseudorabies virus was injected into the diaphragm of the ferret ... | 1999 | 10338316 |
| effects of granisetron, a selective 5-ht3 receptor antagonist, on ouabain-induced emesis in ferrets. | the antiemetic effect of granisetron, a selective 5-ht3 receptor antagonist, on ouabain-induced emesis was studied using ferrets. in order to clarify the relationship between ouabain-induced emesis and serotonin (5-ht), we examined its effects on 5-ht release from the isolated ileum. afferent vagal nerve activity was also determined. an intravenous bolus injection of ouabain (0.1-1.0 mg/kg) produced emesis in a dose-dependent manner. ouabain-induced emesis was inhibited by pretreatment with gran ... | 1998 | 10342910 |
| the role of spontaneous retinal activity before eye opening in the maturation of form and function in the retinogeniculate pathway of the ferret. | during early mammalian development, inputs from the two retinas intermix within the lateral geniculate nucleus (lgn), then segregate during the first postnatal week into layers that receive input from a single retina. functionally, the lgn also changes markedly during the first postnatal month; early geniculate responses to retinal input are mainly excitatory, then inhibitory circuits mature within the lgn. these remarkable changes in form and function of the retinogeniculate pathway occur at a ... | 1999 | 10349970 |
| cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets. | lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. intake of lycopene-rich foods was recently associated with decreased risk for several chronic diseases. the observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans-lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. we tested this hypothesis ... | 1999 | 10356083 |
| intracerebroventricular infusion of the galanin antagonist m40 attenuates heterosexual partner preference in ferrets. | gonadectomized, estradiol-treated male and female ferrets (mustela furo) received intracerebroventricular (i.c.v.) infusions of 4 doses of the galanin receptor antagonist m40 or galanin and were allowed to approach breeding male or female ferrets that were placed behind wire mesh barriers in the goal boxes of a t maze. after i.c.v. infusion of saline, subjects strongly preferred to approach stimulus ferrets of the opposite sex. male and female subjects approached these preferred stimulus animals ... | 1999 | 10357463 |
| regulation of na+-k+-2cl- cotransport by protein phosphorylation in ferret erythrocytes. | 1. na+-k+-2cl- cotransport in ferret erythrocytes was measured as the bumetanide-sensitive uptake of 86rb. 2. the resting cotransport rate was high but could be increased threefold by treating erythrocytes with calyculin a, a potent inhibitor of serine/threonine phosphatases. twenty nanomolar was sufficient to maximally and rapidly (within 4 min) stimulate transport. 3. the effects of several kinase inhibitors were tested. high concentrations of k-252a, k-252b, calphostin c and hypericin caused ... | 1999 | 10358111 |
| isozyme-specific inhibitors of protein kinase c translocation: effects on contractility of single permeabilized vascular muscle cells of the ferret. | 1. the effects on contractility of three peptides reported to inhibit protein kinase c (pkc) translocation in an isozyme-specific manner were studied: a peptide from the c2 domain of conventional pkcs (c2-2), a peptide from the n-terminal variable domain of epsilonpkc (epsilonv1-2) and a peptide (abp) from the actin-binding domain of epsilonpkc (epsilon(223-228)). 2. isometric force was directly recorded from individual hyperpermeable ferret portal vein or aortic smooth muscle cells. 3. phenylep ... | 1999 | 10358112 |
| organophosphorus-induced neurotoxicity in the absence of neuropathy target esterase inhibition: the effects of triphenyl phosphine in the european ferret. | abou-donia et al. (in toxicologist, vol. 30, 1996) have reported that repeated oral administration of the organo-phosphorus compound triphenyl phosphine (tppn) to the domestic chicken results in neuropathological changes in the spinal cord and peripheral nerves, accompanied by ataxia and paralysis. this study also noted that single doses of tppn resulted in no inhibition of the enzymes neuropathy target esterase (nte) and acetylcholinesterase (ache). we undertook the present study to determine t ... | 1999 | 10367344 |
| in vitro recordings of afferent fibres with receptive fields in the serosa, muscle and mucosa of rat colon. | 1. colonic afferent fibres were recorded using a novel in vitro preparation. fibres with endings in the colonic mucosa are described, along with those in muscle and serosa, and their responses to a range of mechanical and chemical luminal stimuli. 2. mechanical stimuli were applied to the tissue, which included stretch, blunt probing of the mucosa and stroking of the mucosa with von frey hairs (10-1000 mg). chemical stimuli were applied into a ring that was placed over the mechanoreceptive field ... | 1999 | 10373708 |
| animal models for gastric helicobacter immunology and vaccine studies. | over the last decade animal models have been used extensively to investigate disease processes and therapy for helicobacter pylori infections. the h. pylori animal models which have been used in pathogenesis and vaccine studies include the gnotobiotic pig, non-human primates, cats, dogs, and several species of rodents including mice, rats, gerbils and guinea pigs. h. felis infection of mice and h. mustelae infection of ferrets have also been used. recently, investigators have begun using transge ... | 1999 | 10378428 |
| development of inhibitory circuitry in visual and auditory cortex of postnatal ferrets: immunocytochemical localization of gabaergic neurons. | the goal of this study was to describe the development of gamma-aminobutyric acid (gaba)-containing neurons in visual and auditory cortex of ferrets. the laminar and tangential distribution of neurons containing excitatory, inhibitory, and neuromodulatory substances constrain the potential circuits which can form during development. ferrets are born at an early stage of brain development, allowing examination of inhibitory circuit formation in cerebral cortex prior to thalamocortical ingrowth an ... | 1999 | 10379919 |
| effects of nasal obstruction on eustachian tube function and middle ear pressure. | to evaluate the relationship between nasal obstruction and otitis media, 10 ferrets were studied before and after either unilateral (e = 5) or bilateral (n = 5) nasal obstruction. observations included otomicroscopic assessments of middle ear status, tympanometric recordings of middle ear pressure and forced-response, inflation-deflation and continuous monitoring tests of eustachian tube function. during the 6 8 week post-obstruction follow-up period no animal developed evidence of otitis media. ... | 1999 | 10380742 |
| nematode-induced jejunal inflammation in the ferret causes long-term changes in excitatory neuromuscular responses. | enteric infections in animals and humans have proven the link between mucosal inflammation and gastrointestinal motor dysfunction. the goal of the present investigation was to study the long-term effects of mucosal inflammation on the neuromuscular functions of the small intestine in a ferret model of primary trichinella spiralis infection. myeloperoxidase activity and isometric contractions of isolated jejunal muscles were studied on days 8, 30, and 60 postinfection (pi). the peak increase in m ... | 1999 | 10381764 |
| laboratory animal models in periodontology. | animal models are needed to objectively evaluate the pathogenesis of human periodontal diseases and its various treatment modalities. selection of the appropriate animal model depends on the similarity of the periodontium and the nature of the disease to that of humans. the more commonly used animal models for studying the pathogenesis of periodontal disease, use of implants and guided tissue regeneration have been dogs and nonhuman primates. periodontal disease in rodents has not been found to ... | 1999 | 10382571 |
| intracellular free calcium accumulation in ferret vascular smooth muscle during crystalloid and blood cardioplegic infusions. | the effects of magnesium- and potassium-based crystalloid and blood-containing cardioplegic solutions on coronary smooth muscle intracellular free calcium ([ca2+]i) accumulation and microvascular contractile function were examined. | 1999 | 10384199 |
| hybrid logistic characterization of isometric twitch force curve of isolated ferret right ventricular papillary muscle. | we previously found that the isovolumic pressure curve of the left ventricle and the isometric twitch force curve of the right ventricular in situ papillary muscle, both of the blood-perfused canine heart, were precisely fitted by our newly proposed hybrid logistic function. this function describes the difference between the two s-shaped logistic functions for the rising and falling components: a/[1+exp{-(4b/a)(t-c)}]-d/[1+exp{-(4e/d)(t-f)}]+g. this function characterizes comprehensively both ve ... | 1999 | 10393349 |
| pattern formation by retinal afferents in the ferret lateral geniculate nucleus: developmental segregation and the role of n-methyl-d-aspartate receptors. | the projection from the retina to the lateral geniculate nucleus (lgn) in ferrets segregates during development into eye-specific layers and on/off sublayers. the projection pattern and the morphology of single axons was examined at several postnatal ages. the axons progress from a simple, sparsely branched morphology at birth to crude arbors at postnatal day 7 (p7). at p14-p15, axons have terminal arbors that span one eye-specific layer. by p19-p21, retinal afferents in the a layers have segreg ... | 1999 | 10404257 |
| pharmacology of g-1-64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action. | chances are slim that a clinically useful ultra-short-acting neuromuscular blocking agent of rapid onset will emerge from the benzylisoquinolinium or the aminosteroid series to which all currently popular relaxants belong. g-1-64 is a promising prototype of a new series of bis-quaternary ammonium salt of bistropinyl diester derivatives we have synthesized and studied in the laboratory. | 1999 | 10408820 |
| sarcoplasmic reticulum ca(2+) release by 4-chloro-m-cresol (4-cmc) in intact and chemically skinned ferret cardiac ventricular fibers. | the purpose of this study was to determine whether 4-chloro-m-cresol (4-cmc) could generate caffeine-like responses in ferret cardiac muscle. the concentration dependence of 4-cmc-mediated release of ca(2+) from the sarcoplasmic reticulum was studied in intact cardiac trabeculae and saponin-skinned fibers in which the sarcoplasmic reticulum was loaded with ca(2+). in intact and saponin-skinned preparations isolated from right ventricle, the effect of 4-cmc on sarcoplasmic reticulum ca(2+) conten ... | 1999 | 10411565 |
| interspecies differences in the cardiac negative inotropic effects of beta(3)-adrenoceptor agonists. | the aim of the present study was to compare the effects of three preferential (brl 37344, sr 58611, cl 316 243) and a partial (cgp 12177) beta-adrenoceptor (beta(3)-ar) agonists on the contractility of ventricular strips sampled from various mammalian species including humans. in the human heart, all beta(3)-ar agonists tested decreased contractility by 40 to 60% below control with an order of potency: brl 37344 > cl 316 243 = sr 58611 >> cgp 12177. in the dog, the negative inotropic effects pro ... | 1999 | 10411579 |
| correlational structure of spontaneous neuronal activity in the developing lateral geniculate nucleus in vivo. | the properties of spontaneous activity in the developing visual pathway beyond the retina are unknown. multielectrode recordings in the lateral geniculate nucleus (lgn) of awake behaving ferrets, before eye opening, revealed patterns of spontaneous activity that reflect a reshaping of retinal drive within higher visual stages. significant binocular correlations were present only when cortico-thalamic feedback was intact. in the absence of retinal drive, cortico-thalamic feedback was required to ... | 1999 | 10417392 |
| influenza virus subtype cross-reactivities of haemagglutination inhibiting and virus neutralising serum antibodies induced by infection or vaccination with an iscom-based vaccine. | in order to study the levels of cross-reactivity of the influenza virus-specific antibody response upon infection or vaccination, usually hemagglutination inhibition assays are performed. in the present study post-infection ferret sera and serum samples obtained from cynomolgus macaques which were vaccinated with an iscom preparation based on the influenza virus strain a/netherlands/18/94 (h3n2) were analyzed for cross-reactivity in the hemagglutination inhibition assay and in virus neutralizati ... | 1999 | 10418897 |
| genetic diversity within cryptosporidium parvum and related cryptosporidium species. | to assess the genetic diversity in cryptosporidium parvum, we have sequenced the small subunit (ssu) rrna gene of seven cryptosporidium spp., various isolates of c. parvum from eight hosts, and a cryptosporidium isolate from a desert monitor. phylogenetic analysis of the ssu rrna sequences confirmed the multispecies nature of the genus cryptosporidium, with at least four distinct species (c. parvum, c. baileyi, c. muris, and c. serpentis). other species previously defined by biologic characteris ... | 1999 | 10427023 |
| neural control mechanisms within airways: disruption by respiratory syncytial virus. | among the factors influencing airway function are neural control mechanisms, including adrenergic, cholinergic, nonadrenergic noncholinergic inhibitory, and nonadrenergic noncholinergic excitatory pathways. respiratory infections affect these pathways in ways that are not entirely clear. | 1999 | 10431135 |
| stimulation of na+-k+-2cl- cotransport by arsenite in ferret erythrocytes. | 1. na+-k+-2cl- cotransport activity was measured in ferret erythrocytes as the bumetanide-sensitive uptake of 86rb. 2. the na+-k+-2cl- cotransport rate was stimulated by treating erythrocytes with sodium arsenite but not by sodium arsenate (up to 1 mm). stimulation took an hour to develop fully. arsenite had no effect on bumetanide-resistant 86rb uptake. 3. in cells stored for 3 days or less, cotransport stimulation by arsenite could be described by assuming arsenite either acts at a single site ... | 1999 | 10432345 |
| the critical period for ocular dominance plasticity in the ferret's visual cortex. | microelectrode recordings and optical imaging of intrinsic signals were used to define the critical period for susceptibility to monocular deprivation (md) in the primary visual cortex of the ferret. ferrets were monocularly deprived for 2, 7 or >14 d, beginning between postnatal day 19 (p19) and p110. the responses of visual cortical neurons to stimulation of the two eyes were used to gauge the onset, peak, and decline of the critical period. mds ending before p32 produced little or no loss of ... | 1999 | 10436053 |
| maps of central visual space in ferret v1 and v2 lack matching inputs from the two eyes. | in the visual cortex, the representation of central visual space is supplied by matching geniculate inputs that are driven exclusively by one eye or the other. in layer 4 of early visual areas (v1 in primates and v1 and v2 in cat), these inputs form a nearly uniform array of small ocular dominance domains, while preserving overall topographic order within the cortical map. in ferret, however, ocular dominance domains in different regions of the visual cortex are strikingly irregular in size and ... | 1999 | 10436063 |
| the tachykinin nk1 receptor in the brain: pharmacology and putative functions. | after its discovery in 1931, substance p (sp) remained the only mammalian member of the family of tachykinin peptides for several decades. tachykinins thus refer to peptides sharing the common c-terminal amino acid sequence phe-x-gly-leu-met x nh2. in recent years the family of mammalian tachykinins has grown with the isolation of two novel peptides from bovine and porcine central nervous system (cns), neurokinin a and neurokinin b. in parallel with the identification of multiple endogenous tach ... | 1999 | 10443564 |
| muscarinic regulation of ca2+ signaling in mammalian atrial and ventricular myocardium. | the differential regulation of the contractility of mammalian atrial and ventricular myocardium upon activation of muscarinic receptors can be ascribed, for the most part, to alterations in intracellular ca2+ transients. however, alterations in myofibrillar sensitivity to ca2+ ions also contribute to such regulation. in atrial muscle, the following actions are all associated with the corresponding alterations in the amplitude of ca2+ transients in the same direction as those in the strength of t ... | 1999 | 10443574 |
| the neuronal form of nitric oxide synthase is required for pattern formation by retinal afferents in the ferret lateral geniculate nucleus. | the ferret retinogeniculate projection undergoes activity-dependent refinement of connections that become restricted to eye specific laminae and on/off sublaminae in the lateral geniculate nucleus (lgn). we have previously shown that the developmental process by which on/off sublaminae form requires n-methyl-d-aspartate (nmda) receptors and nitric oxide (no). in this study, we investigate the role of the neuronal form of no synthase (nnos) in sublaminar refinement. this isoform of nos may be cou ... | 1999 | 10446349 |
| effect of varying the intensity and train frequency of forelimb and cerebellar mossy fiber conditioned stimuli on the latency of conditioned eye-blink responses in decerebrate ferrets. | to study the role of the mossy fiber afferents to the cerebellum in classical eye-blink conditioning, in particular the timing of the conditioned responses, we compared the effects of varying a peripheral conditioned stimulus with the effects of corresponding variations of direct stimulation of the mossy fibers. in one set of experiments, decerebrate ferrets were trained in a pavlovian eye-blink conditioning paradigm with electrical forelimb train stimulation as conditioned stimulus and electric ... | 2006 | 10456057 |
| erratum | hahm j-o, cramer ks, sur m. 1999. pattern formation by retinal afferents in the ferret lateral geniculate nucleus: developmental segregation and the role of n-methyl-d-aspartate receptors. j comp neurol 411:327-345. due to a printer's error, figures 6 and 12 were transposed after the proofs of the article had been approved by the author. the correct figures and legends are reprinted on the following pages. the publisher regrets the error. | 1999 | 10464365 |
| human serum-resistant retroviral vector particles from galactosyl (alpha1-3) galactosyl containing nonprimate cell lines. | retroviral vector particles (rvp) which are resistant to inactivation by human serum will be needed for many in vivo gene therapy applications. murine-based producer cell lines generate rvp which are inactivated by human serum, reportedly due to the presence of the galactosyl (alpha1-3) galactosyl carbohydrate moiety (alphagal) on these and other nonprimate producer cells and rvp. consequently, human cells (which lack the alphagal moiety) have been developed as producer cell lines for generation ... | 1999 | 10467364 |
| the effect of fentanyl on c-fos expression in the trigeminal brainstem complex produced by pulpal heat stimulation in the ferret. | we have previously shown that fos-like immunoreactivity (fos-li) is evoked in the brainstem of ferrets following stimulation of pulpal a delta and c fibers originating from the maxillary canine. this study evaluated the effects of the mu-opioid receptor agonist fentanyl on fos expression evoked by noxious thermal stimulation of the right maxillary and mandibular canines in pentobarbital/chloral hydrate anesthetized adult male ferrets. pulpal heating evoked fos expression in two distinct regions ... | 1999 | 10467925 |
| characterization of endothelin receptors in the anesthetized ferret: a novel model for investigating the functional et(b) receptor subtypes. | the pharmacology of endothelin (et)-1, big et-1, et-3, and s6c were characterized in the anesthetized ferret to assess whether this species would provide a new and suitable nonrodent model to be used in characterization of endothelin antagonists. unlike other species such as dog, rabbit, and rat, the ferret exhibited a dose-dependent pressor response to both et-1 and big et-1 with no preceding vasodilatory response. the median effective concentration (ed50) values were 0.047+/-0.009 and 0.469+/- ... | 1999 | 10470993 |
| survival of axotomized retinal ganglion cells in peripheral nerve-grafted ferrets. | peripheral nerve (pn) grafting to the optic nerve stump stimulates not only axonal regeneration of the axotomized retinal ganglion cells (rgcs) into the grafted pn but also their survival. the purpose of the present study was to determine the number, distribution, and soma diameter of only surviving rgcs without regenerated axons and surviving rgcs with regenerated axons in pn-grafted mammals. | 1999 | 10476803 |
| effect of field capture on the measurement of cellular immune responses in wild ferrets (mustela furo), vectors of bovine tuberculosis in new zealand. | ferrets are recognised as significant wildlife vectors of bovine tuberculosis (tb) in new zealand. disease management strategies, such as the development of a protective wildlife vaccine, could be assisted by the ability to measure pertinent cellular immune responses among wild animals. in the present study, we investigated whether it is possible to measure in vitro lymphocyte reactivity in wild-caught ferrets, and also determined levels of physiological stress in these animals, and we compared ... | 1999 | 10478422 |
| pregnancy toxemia in the european ferret (mustela putorius furo). | pregnancy toxemia may lead to appreciable mortality among jills and their offspring. the objective of this report was to increase awareness of the disease, its likely cause, and practical prevention and treatment measures. | 1999 | 10480641 |
| improvement of cisplatin-induced emesis and delayed gastric emptying by kb-r6933, a novel 5-ht3 receptor antagonist. | the effects of a novel 5-hydroxytryptamine3 (5-ht3) receptor antagonist, kb-r6933, 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)-benzimidazole dimaleate, on emesis and delayed gastric emptying induced by cisplatin were assessed in experimental models. prophylactic intravenous or oral treatment with kb-r6933 prolonged the latent period until the first emetic episode and decreased the number of emetic episodes induced by cisplatin in ferrets. kb-r6933 immediately inhibited the subsequent ... | 1999 | 10480662 |
| gaba(b) receptors inhibit mechanosensitivity of primary afferent endings. | the modulatory effects of baclofen on the sensitivity of peripheral afferent endings to mechanical stimulation were investigated using an in vitro ferret gastroesophageal vagal afferent preparation. changes in sensitivity of three types of gastroesophageal vagal afferent endings previously categorized as mucosal, tension, and tension-mucosal (tm) receptors according to their mechanoreceptive field characteristics were investigated. baclofen (30-200 microm) dose dependently reduced responses of m ... | 1999 | 10493759 |
| conductive hearing loss produces a reversible binaural hearing impairment. | conductive hearing loss, produced by otitis media with effusion, is widespread in young children. however, little is known about its short- or long-term effects on hearing or the brain. to study the consequences of a conductive loss for the perception and processing of sounds, we plugged the left ear canal of ferrets for 7-15 months during either infancy or adulthood. before or during plugging, the ferrets were trained to perform a binaural task requiring the detection of a 500 hz tone, position ... | 1999 | 10493771 |
| rods and cones project to the inner plexiform layer during development. | mature rod and cone photoreceptor cells extend terminals to the outer plexiform layer (opl), where they form characteristic spherules or pedicles, synapsing with the second-order neurons of the inner nuclear layer (inl). the present study demonstrates that, prior to the formation of this connectivity, immature rods and cones in the ferret extend processes beyond the level of the horizontal cells and future opl, reaching the inner plexiform layer (ipl). the number of processes extending to the ip ... | 1999 | 10494074 |
| surgical treatment and long-term outcome of ferrets with bilateral adrenal tumors or adrenal hyperplasia: 56 cases (1994-1997). | to determine signalment, clinical signs, concurrent diseases, response to surgical treatment, and long-term outcome of ferrets with bilateral adrenal tumors or adrenal hyperplasia. | 1999 | 10496136 |
| coexistence of widespread clones and large radial clones in early embryonic ferret cortex. | cell lineage analysis in rodents has shown that the cerebral cortex is formed from both widespread and large radial clustered clones representing partly distinct lineages and producing differing cell types. since previous cell lineage analysis of the ferret cortex using retroviral libraries showed that most neurons labeled at e33-e35 formed widespread clones, we determined whether clones labeled earlier in neurogenesis showed a greater tendency to form coherent radial clones. clones labeled at e ... | 1999 | 10498282 |
| blockade of putative beta4- and beta1-adrenoceptors by carvedilol in ferret myocardium. | the putative beta4-adrenoceptor mediates positive inotropic effects, action potential shortening and arrhythmias in ferret ventricle. here we compared the affinity of carvedilol at the putative beta4-adrenoceptor and beta1-adrenoceptor, activated by (+/-)-cgp 12177 and (-)-isoprenaline, respectively. in paced right ventricular preparations, carvedilol (0.01-10 micromol/l) was a simple competitive antagonist of the positive inotropic effects of (+/-)-cgp 12177 (slope of schild-plot = 1.02, pk(b) ... | 1999 | 10498290 |
| submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (lef1). | previous studies have demonstrated that transcription of the lymphoid enhancer binding factor 1 (lef1) gene is upregulated in submucosal gland progenitor cells just prior to gland bud formation in the developing ferret trachea. in the current report, several animal models were utilized to functionally investigate the role of lef1 in initiating and supporting gland development in the airway. studies on lef1-deficient mice and antisense oligonucleotides in a ferret xenograft model demonstrate that ... | 1999 | 10498680 |
| ferret pyramidal cell dendritogenesis: changes in morphology and ganglioside expression during cortical development. | pyramidal cell ontogenesis and basilar dendritic differentiation were evaluated concomitantly with ganglioside expression and distribution in ferret cerebral cortex. layer v neurons began basilar dendritogenesis on postnatal day 1 (p1) with a peak in dendritic arborization occurring at p21. layer ii/iii neurons, in contrast, were in early stages of basilar dendritic differentiation at p14, resulting in a complex dendritic arbor at p28. high performance thin-layer chromatography showed numerous c ... | 1999 | 10502250 |
| role of nitric oxide synthase and cyclooxygenase in pulmonary vascular control in isolated perfused lungs of ferrets, rats and rabbits. | dilator products of nitric oxide synthase (nos) and cyclooxygenase (cox) may contribute to the low normal pulmonary artery pressure (ppa). in isolated perfused lungs of ferrets, rabbits and rats we investigated this hypothesis by blockade of nos with l-name (l-nitro-arginine methyl ester) and cox with meclofenamate. there were species differences. inhibition of either enzyme caused little rise in ppa in ferrets and rats but inhibition of both enzymes caused huge increases in ppa. we suggest this ... | 1999 | 10502658 |
| vaccines. | extensive research with mice has shown that animals can be protected from or cured of helicobacter infection by immunization. a therapeutic effect has also been demonstrated in ferrets. the possibility of developing a vaccine against h. pylori-associated diseases that will work in humans has been the stimulus for intense research activity. a major subset of lymphocytes involved in immunity against invading pathogens is the cd4+ t-lymphocytes, divided into th1 and th2 phenotypes. th1 cells are in ... | 1999 | 10503828 |
| recording and manipulating the in vivo correlational structure of neuronal activity during visual cortical development. | many aspects of visual cortical functional architecture, such as orientation and ocular dominance columns, are present before animals have had any visual experience, indicating that the initial formation of cortical circuitry takes place without the influence of environmental cues. for this reason, it has been proposed that spontaneous activity within the developing visual pathway carries instructive information to guide the early establishment of cortical circuits. recently developed recording ... | 1999 | 10504189 |
| heterogeneous basal expression of nitric oxide synthase and superoxide dismutase isoforms in mammalian heart : implications for mechanisms governing indirect and direct nitric oxide-related effects. | the basal expression patterns of no synthase (nos; endothelial [enos], neuronal [nnos], and cytokine-inducible [inos]) and superoxide dismutase (sod; extracellular membrane bound [ecsod], mnsod, and cuznsod) isoforms in ferret heart (tissue sections and isolated myocytes) were determined by immunofluorescent localization. we demonstrate the following for the first time in the mammalian heart: (1) heterogeneous expression patterns of the 3 nos and 3 sod isoforms among different tissue and myocyte ... | 1999 | 10506482 |
| the effects of early prenatal monocular enucleation on the routing of uncrossed retinofugal axons and the cellular environment at the chiasm of mouse embryos. | whereas it has been shown that early monocular enucleations produce a reduction in the uncrossed pathway from the surviving eye in rats and ferrets, similar evidence for binocular interactions in the development of the uncrossed component in mice is currently open to question. using retrograde tracing, we have investigated the time course of changes in the uncrossed retinofugal pathway immediately after the early prenatal monocular enucleation in mouse embryos. removal of one eye from c57 pigmen ... | 1999 | 10510186 |
| the role of sensory neuropeptides and nitric oxide on pulpal blood flow and tissue pressure in the ferret. | a study was designed to investigate the effects of close intra-arterial infusion of antagonists to the sensory neuropeptides calcitonin gene-related peptide and substance p, as well as the effect of the nitric oxide synthesis inhibitor l-name on pulpal blood flow and interstitial fluid pressure during resting conditions and after electrical tooth stimulation. the micropuncture technique was used to measure tissue pressure and laser-doppler flowmetry for blood flow recordings in ferret canine tee ... | 1999 | 10512388 |
| inhibition of transient les relaxations and reflux in ferrets by gaba receptor agonists. | transient lower esophageal sphincter (les) relaxation is the major mechanism of gastroesophageal reflux. this study uses an established ferret model to evaluate gaba(b) receptor agonists' ability to reduce triggering of transient les relaxations. one hundred sixty manometric/ph studies were performed on 18 conscious ferrets. in untreated animals, intragastric infusion of 25 ml glucose (ph 3.5) led to 2.0 +/- 0.6 reflux episodes over the first 30 min. twenty-nine of forty-seven reflux episodes oc ... | 1999 | 10516154 |
| liquid chromatographic-tandem mass spectrometric method for the determination of the neuraminidase inhibitor zanamivir (gg167) in human serum. | an lc-ms-ms method for the analysis of the neuraminidase inhibitor, zanamivir, in human serum is described. zanamivir was extracted from protein precipitated human serum samples using isolute scx solid-phase extraction cartridges and analysed using reversed-phase chromatography with turboionspray atmospheric pressure ionisation followed by mass spectrometric detection. the method uses a stable isotope internal standard, is highly specific and sensitive for a compound of this type and has been us ... | 1999 | 10517361 |
| influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling rats. | the central neurochemical and neuroendocrine effects of a psychogenic (ferret exposure) and a neurogenic (restraint) stressor were assessed in rats that had been selectively bred for differences in amygdala excitability manifested by either fast or slow amygdala kindling epileptogenesis. while these rat lines differ in their emotionality, their behavioral styles were dependent on the nature of the stressor to which they were exposed. during restraint, the slow rats were mostly immobile, while fa ... | 1999 | 10517953 |
| ultrasonography and fine needle aspirate cytology of the mesenteric lymph node in normal domestic ferrets (mustela putorius furo). | the large mesenteric lymph node of 28 normal ferrets was imaged with ultrasound. the large node, located in the mid-abdomen at the root of the mesentery, was round to ovoid and uniformly hyperechoic. mean ultrasonographic dimensions of the lymph node were 12.6 +/- 2.6 mm by 7.6 +/- 2.0 mm. fine needle aspirates of 20 lymph nodes were obtained either using ultrasound guided free-hand techniques or at necropsy. the cytological descriptions were compared to histological descriptions of 13 lymph nod ... | 1999 | 10519312 |
| an autoradiographic assessment of epithelial cell proliferation and post-natal maturation of the tracheal epithelium in infant ferrets. | the tracheal epithelium of infant ferrets undergoes rapid postnatal maturation over the first month of life to achieve the pseudostratified columnar configuration characteristic of the large airways of other mammals. we have used in vivo pulsing with tritiated thymidine ((3)ht) to elicit autoradiographic labeling of cells synthesizing nucleic acids in order to characterize more fully the contribution to development of different cell types comprising the nascent epithelial layer during this perio ... | 1999 | 10521783 |
| isoforms of the small non-catalytic subunit of smooth muscle myosin light chain phosphatase. | chicken gizzard smooth muscle myosin light chain phosphatase is composed of a approximately 37 kda catalytic subunit, a approximately 110 kda myosin binding or targeting subunit and a approximately 20 kda subunit (mps) whose function is as yet undefined. it was reported previously that a cloned chicken gizzard mps cdna encodes a protein of 186 amino acids (aa) [y.h. chen, m.x. chen, d.r. alessi, d.g. gampbell, c. shanahan, p. cohen, p.t.w. cohen, febs lett. 356 (1994) 51-55]. more recently, we o ... | 1999 | 10525148 |
| chemoprophylaxis of influenza a virus infections, with single doses of zanamivir, demonstrates that zanamivir is cleared slowly from the respiratory tract. | zanamivir (4-guanidino-2,4-dideoxy-2,3-dehydro-n-acetylneuraminic acid; relenza; gg167) is a potent and highly specific neuraminidase (sialidase) inhibitor with inhibitory activity in vivo against both influenza a and b viruses. this compound has been extensively tested in both mouse and ferret models of influenza and has recently been approved for the treatment of influenza in europe and australasia. the compound markedly reduces the clinical course of disease in humans when given therapeutical ... | 1999 | 10543741 |
| the protein composition of ferret parotid saliva as revealed by high-resolution electrophoretic methods. | ferret parotid saliva has been analysed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) and two-dimensional electrophoresis (2-de) to determine, for the first time, its protein composition. sds-page, in combination with coomassie brilliant blue (cbb) staining, revealed up to 20 bands and the patterns were characterised by major protein constituents of mr 105000, 51000, 47000, 33000, 22000 and 16 400 common to all samples from all animals. sequential samples collected f ... | 1999 | 10546812 |
| [the ferret. 1. general and zoologic technical information]. | this series of articles on the ferret provide a practical handout for companion animal practitioners. aspects concerning the housing, nutrition, and reproduction of ferrets are briefly described, followed by a more detailed description of diagnostic procedures such as blood collection, anaesthesia, small surgical procedures, preventive veterinary care, and hospitalization. frequently seen clinical problems with their differential diagnosis are discussed, and the cause, clinical symptoms, diagnos ... | 1999 | 10549089 |
| the development of retinal ganglion cell dendritic stratification in ferrets. | a signature feature of mature ferret retinal ganglion cells (rgcs) is the stratification of their dendrites within either on or off sublayers of the retinal inner plexiform layer (ipl). dendritic stratification is achieved through the gradual restriction of rgc dendrites which initially ramify throughout the ipl. we examined the time course of stratification by retrogradely labeling ferret retinas with dii at various postnatal ages. stratification of beta and alpha rgc dendrites into either the ... | 1999 | 10549804 |
| using department of veterans affairs administrative databases to examine long-term care utilization for men and women veterans. | we examined long-term care (ltc) utilization by male and female veterans using administrative databases maintained by va. research questions included: (1) which ltc services are utilized? (2) do utilization patterns of older veterans differ from those of elderly persons in the general u.s. population? (3) do ltc needs of veterans vary by gender? we were unable to track ltc utilization of individuals across administrative databases. some databases could only provide information at the national le ... | 1999 | 10554736 |
| effects of altering spectral cues in infancy on horizontal and vertical sound localization by adult ferrets. | we investigated the behavioral consequences of removing the pinna and concha of the external ear bilaterally in infancy on the sound localization ability of adult ferrets. altering spectral cues in this manner has previously been shown to disrupt the development of the neural representation of auditory space in the superior colliculus. using broadband noise stimuli, we tested pinnae-removed ferrets and normal ferrets in three sound localization tasks. in each case, we found that both groups of a ... | 1999 | 10561407 |
| unusual presentation of hemangiosarcoma in a ferret. | 1999 | 10563243 | |
| review of animal models in carotenoid research. | foods containing provitamin a carotenoids are the primary source of vitamin a in many countries, despite the poor bioavailability of carotenoids. in addition, epidemiologic studies suggest that dietary intake of carotenoids influences the risk for certain types of cancer, cardiovascular disease and other chronic diseases. although it would be ideal to use humans directly to answer critical questions regarding carotenoid absorption, metabolism and effects on disease progression, appropriate anima ... | 1999 | 10573562 |
| [the ferret. part 2. veterinary medical information]. | this series of articles on the ferret provide a practical handout for companion animal practitioners. aspects concerning the housing, nutrition, and reproduction of ferrets are briefly described, followed by a more detailed description of diagnostic procedures such as blood collection, anaesthesia, small surgical procedures, preventive veterinary care, and hospitalization. frequently seen clinical problems with their differential diagnosis are discussed, and the cause, clinical symptoms, diagnos ... | 1999 | 10573804 |
| effect of vasoactive intestinal peptide (vip)-related peptides on cholinergic neurogenic and direct mucus secretion in ferret trachea in vitro. | 1 we investigated whether vasoactive intestinal peptide (vip) and its related peptides, pituitary adenylate cyclase activating peptide (pacap) and secretin, regulate cholinergic neural mucus secretion in ferret trachea in vitro, using 35so4 as a mucus marker. we also studied the interaction between vip and secretin on cholinergic mucus output. 2 vip (1 and 10 microm) increased secretion, whereas neither pacap1 - 27, pacap1 - 38 nor secretin (up to 10 microm) increased mucus output. in contrast, ... | 1999 | 10578152 |
| improved auditory spatial acuity in visually deprived ferrets. | we have examined the effects on auditory spatial acuity in the horizontal plane of depriving ferrets of patterned visual cues by binocular eyelid suture in infancy or for a comparable period in adulthood. minimum audible angles (maas) were measured for 500-, 100- and 40-ms broadband noise bursts at the midline and at 45 degrees to one side. a logistic regression analysis revealed no consistent difference between the midline maas of normal and infant lid-sutured ferrets. however, the lateral fiel ... | 1999 | 10583483 |
| [pharmacological review of tropisetron]. | tropisetron is used as an anti-emetic agent against chemotherapy-induced nausea and vomiting. tropisetron shows strong 5-ht3 antagonist and weak 5-ht4 antagonist activities in vitro. in the various animal models of vomiting including chemotherapy- or radiotherapy-induced emesis in the dog and ferret, tropisetron is reported to inhibit the emetic episodes. the potent anti-emetic activity of oral tropisetron rather than the i.p. administered drug suggests that it can act directly from the intestin ... | 1999 | 10584235 |
| partial protection against oral challenge with mycobacterium bovis in ferrets (mustela furo) following oral vaccination with bcg. | ferrets (mustela furo) are important wildlife vectors of bovine tuberculosis (tb) in new zealand. protective vaccination of ferrets may limit the potential of transmission to livestock. | 1999 | 10587325 |
| effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. | neural mechanisms contribute to control of mucus secretion in the airways. fenspiride is a non-steroidal antiinflammatory agent which has a variety of actions, including inhibition of neurogenic bronchoconstriction. the effect of fenspiride on neurally-mediated mucus secretion was investigated in vitro in electrically-stimulated ferret trachea, using(35)so(4)as a mucus marker. cholinergic secretory responses were isolated using adrenoceptor and tachykinin receptor antagonists. tachykinin respons ... | 1999 | 10587477 |
| effects of dark-rearing on triphenyl phosphate-induced neuropathy in the visual system of the developing european ferret (mustela putorius furo). | results of a previous study in our lab (tanaka et al., 1994) suggested that the onset of susceptibility to the organophosphorus compound triphenyl phosphite (tpp) in the developing ferret visual system might be closely related to eye opening and the onset of light stimulation. in order to explore this idea further, tpp was administered to ferret kits that had been raised for varying periods of time in total darkness to assess whether a delay in the onset of light stimulation to the visual system ... | 1999 | 10591489 |
| organization of intracortical circuits in relation to direction preference maps in ferret visual cortex. | neurons in the primary visual cortex are selective for the direction of movement of a visual stimulus. like other stimulus features, direction preference is mapped on the cortical surface in a systematic manner. intracortical synaptic circuits, in particular inhibitory connections, have been implicated in the emergence of direction selectivity. whether intracortical inhibition specifically suppresses responses to the nonpreferred direction or has a nonspecific "thresholding" effect is still cont ... | 1999 | 10594088 |
| short-lasting conditioned stimulus applied to the middle cerebellar peduncle elicits delayed conditioned eye blink responses in the decerebrate ferret. | in delay eye blink conditioning, the conditioned stimulus (cs) ends at the time of the unconditioned stimulus (us). if the cs duration is decreased, there will be a 'trace' period with no ongoing cs before the onset of the us. during this period some neural activity has to continue after the cs offset to: (i) permit association between the cs and the us; and (ii) elicit a conditioned response appearing after the cs offset. in this study we test the role of the cerebellum in maintaining cs activi ... | 1999 | 10594659 |
| oseltamivir. | oseltamivir is the oral prodrug of gs4071, a selective inhibitor of influenza a and b viral neuraminidase. after absorption from the gastrointestinal tract oseltamivir is efficiently converted to gs4071, which is maintained at high and sustained concentrations in plasma. based on studies in rats and ferrets, gs4071 appears to be effectively distributed to all tissues, including major sites of infection in the upper and lower respiratory tracts. oral oseltamivir was an effective treatment in natu ... | 1999 | 10595865 |
| [the ferret. part 3: the diseases of the ferret classified by clinical symptoms]. | the articles regarding the ferret supply a practical hand-out for the companion animal practitioner. features regarding housing, nutrition, and reproduction are briefly described followed by, more in detail, diagnostic procedures such as blood collection, anesthesia, small surgical procedures, preventive veterinary care and hospitalization of the ferret. frequently seen clinical problems with their differential diagnosis are discussed including cause, clinical disease, diagnosis, therapy and if ... | 1999 | 10596398 |
| visual stimulus-dependent changes in interhemispheric eeg coherence in ferrets. | in recent years, the analysis of the coherence between signals recorded from the scalp [electroencephalographic (eeg) coherence] has been used to assess the functional properties of cortico-cortical connections, both in animal models and in humans. however, the experimental validation of this technique is still scarce. therefore we applied it to the study of the callosal connections between the visual areas of the two hemispheres, because this particular set of cortico-cortical connections can b ... | 1999 | 10601443 |