Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| neuralgic amyotrophy and hepatitis e virus infection. | to determine whether there is an association between an acute preceding hepatitis e virus (hev) infection and neuralgic amyotrophy (na), and if so, whether patients with hev-related na differ from patients without an associated hev infection. | 2014 | 24401685 |
| serological cross reactivity to cmv and ebv causes problems in the diagnosis of acute hepatitis e virus infection. | hepatitis e virus (hev) infection is an important public health concern as a major cause of enterically-transmitted hepatitis worldwide. the detectable window of viraemia is narrow, and hev igm and igg rise simultaneously in acute infection. furthermore, previous investigators have shown hev igm false positive reactions occur against ebv, cmv and potentially hepatitis a. a retrospective analysis of hev serology testing was performed at a london tertiary referral hospital over a 3-year period. a ... | 2014 | 24402843 |
| transmission of hepatitis e virus by transfusion: what is the risk? | 2014 | 24405304 | |
| guillain-barré syndrome associated with preceding hepatitis e virus infection. | the aim of the study was to determine whether guillain-barré syndrome (gbs) is associated with preceding hepatitis e virus infection. | 2014 | 24415572 |
| fetal and neonatal health consequences of vertically transmitted hepatitis e virus infection. | hepatitis e virus (hev) infections lead to tens of thousands of deaths annually, mostly in developing countries. hepatitis e poses a significant threat to the health of expectant mothers, a well-noted epidemiologic feature of the disease, but the contribution of vertically transmitted hev infection to fetal and neonatal morbidity and mortality has received limited attention. evidence assembled to date suggests that mother-to-child hev transmission may be frequent and deleterious to the fetus and ... | 2014 | 24420778 |
| development of a novel enzyme-linked immunosorbent assay to detect anti-igg against swine hepatitis e virus. | swine hepatitis e virus (hev) is widespread throughout pigs in both developing and industrialized countries. this virus is an important zoonotic agent and a public concern worldwide. infected pigs are asymptomatic, so diagnosing swine hev relies on detection of the virus or antibodies against the virus. however, several obstacles need to be overcome for effective and practical serological diagnosis. in this study, we developed an enzyme-linked immunosorbent assay (elisa) that used a purified rec ... | 2013 | 24421718 |
| hepatitis e virus infections in humans and animals. | hepatitis e has traditionally been considered an endemic disease of developing countries. it generally spreads through contaminated water. however, seroprevalence studies have shown that hepatitis e virus (hev) infections are not uncommon in industrialized countries. in addition, the number of autochthonous hepatitis e cases in these countries is increasing. most hev infections in developed countries can be traced to the ingestion of contaminated raw or undercooked pork meat or sausages. several ... | 2014 | 24427760 |
| comparison of real-time reverse transcriptase pcr assays for detection of swine hepatitis e virus in fecal samples. | hepatitis e virus (hev) is a major cause of acute viral hepatitis in people in many developing countries and is also endemic in many industrialized countries. mammalian hev (mhev) isolates can be divided into at least four recognized major genotypes. several nucleic acid amplification techniques have been developed for mhev detection, with great differences in sensitivity. the aim of this study was to compare the performances of two singleplex real-time reverse transcriptase (rt) pcr assays for ... | 2014 | 24430450 |
| hepatitis e: an emerging disease. | currently, the infection with the hepatitis e virus represents the most frequent cause for acute hepatitis and jaundice in the world. according to who estimations, around two billion people, representing one third of the world's population, live in endemic areas for hev and, therefore, are at risk of infection. in developed countries, the circulation of the virus in both human and animal (swine, boar, deer) sewage has been confirmed; however, the incidence rate is low compared to that of develop ... | 2014 | 24434240 |
| hepatitis e virus reinfections in solid-organ-transplant recipients can evolve into chronic infections. | hepatitis e virus (hev) infections are a major cause of acute hepatitis in developing and industrialized countries. little is known about anti-hev immunity in solid-organ recipients. | 2014 | 24436450 |
| course and treatment of chronic hepatitis e virus infection in lung transplant recipients. | persistent hepatitis e virus (hev) infections have been described in various transplant cohorts. however, the frequency and the course of hev infection in lung transplant recipients (lu-tr) are not well defined. | 2014 | 24438577 |
| should we screen blood products for hepatitis e virus rna ? | 2014 | 24439737 | |
| hepatitis e in liver transplant recipients in the rhône-alpes region in france. | in developed countries, hepatitis e virus (hev) is considered an emerging pathogen, but prevalence seems highly variable according to previous european studies. as hev can lead to chronic infections in immunosuppressed patients, it is thus essential to evaluate the prevalence and incidence of this infection. | 2014 | 24445407 |
| [epidemiology of hepatitis e virus infection in spain]. | the general features of the epidemiology and ecology of hepatitis e virus in spain are already known after 20 years of investigations. genotype 3 strains, mainly from sub-genotype 3f, circulated among swine livestock and certain wild mammals, and would be sporadically transmitted to humans through direct contact with the reservoirs or by consumption of foods derived from them. bivalve shellfish contaminated by hepatitis e virus from sewage could also play a role in transmission. although the int ... | 2015 | 24447919 |
| liver transplantation for acute liver failure related to autochthonous genotype 3 hepatitis e virus infection. | hepatitis e virus of genotype 3 (hev-3) is an emerging cause of sporadic autochthonous acute hepatitis in europe. although spontaneous outcome of hepatitis e is usually favorable, fulminant liver failure has been described worldwide. in europe, autochthonous hepatitis e associated with fulminant hepatic failure and leading to liver transplantation has been exceptionally reported. we report here four cases of fulminant and sub-fulminant hepatitis e proposed for liver transplantation in marseille ... | 2014 | 24462173 |
| increased hev seroprevalence in patients with autoimmune hepatitis. | hepatitis e virus (hev) infection takes a clinically silent, self-limited course in the far majority of cases. chronic hepatitis e has been reported in some cohorts of immunocompromised individuals. the role of hev infections in patients with autoimmune hepatitis (aih) is unknown. | 2014 | 24465537 |
| absence of chronic hepatitis e in a german cohort of common variable immunodeficiency patients. | cases of chronic or prolonged hepatitis e virus (hev) infections have been described in solid organ transplant recipients, hiv infected patients and in patients with malignancies or idiopathic cd4(+) t lymphopenia. it is unknown if hev infection also takes chronic courses in patients with common variable immunodeficiency (cvid). we studied a cohort of 73 cvid patients recruited in a low endemic central european country. none of the subjects tested positive for hev rna or anti-hev igg. immunoglob ... | 2012 | 24470942 |
| acute viral hepatitis - should the current screening strategy be modified? | the epidemiology of viral hepatitis has changed. since the introduction of safe and effective vaccines for hepatitis a and b in 1980s, the incidence of acute infections caused by these viruses has been declining in the uk. at the same time, hepatitis e virus (hev) has been recognised as an increasingly important cause of acute hepatitis, but testing is not widely available. | 2014 | 24472576 |
| long-term hepatitis e viral load kinetics in an immunocompromised patient treated with ribavirin. | hepatitis e virus (hev) can cause chronic infections in immunocompromised hosts. viral kinetics in plasma and stools are poorly understood, particularly during antiviral treatment. prolonged faecal shedding may be a concern for transmission. we describe hev kinetics in an immunocompromised patient with prolonged faecal shedding despite undetectable viraemia on ribavirin treatment. | 2014 | 24476456 |
| fatal fulminant hepatitis e associated with autoimmune hepatitis and excessive paracetamol intake in southeastern france. | we present, to our knowledge, the first case of fatal fulminant liver failure associated with hepatitis e virus infection, autoimmune hepatitis, and excessive paracetamol intake, which occurred in a 77-year-old woman. hepatitis e testing should be performed in severe acute liver failure cases, even when another cause has been identified. | 2014 | 24478416 |
| seroprevalence of hepatitis e antibodies in a population of recyclable waste pickers in brazil. | hepatitis e virus (hev) infection represents an important cause of acute viral hepatitis. selective waste collection is a widespread activity carried out by the urban poor, and recyclable waste pickers have a lifestyle that makes this group highly vulnerable to unfavorable socio-economic and environmental factors. to date, the epidemiology of hev infection in this population remains unknown. | 2014 | 24480723 |
| genome sequence of a hepatitis e virus of genotype 3e from a chronically infected kidney transplant recipient. | hepatitis e virus (hev) is an emerging cause of acute and chronic hepatitis in immunocompromised patients in europe. we report the genome sequence of a genotype 3e hev from a chronically infected kidney transplant recipient in southeastern france, the second hev genome sequence from a transplant recipient and the first of subtype 3e. | 2014 | 24482510 |
| presence of mycobacterium avium subspecies and hepatitis e virus in raw meat products. | meat and meat products may be the source of various pathogenic and potentially pathogenic agents for humans. we ascertained the occurrence of mycobacterium avium subsp. paratuberculosis, subsp. avium, and subsp. hominissuis, and hepatitis e virus in retail raw meat products. the dna of at least one of the target m. avium subspecies was detected in 26 (29.2%) of 89 analyzed samples of meat products. fourteen (15.7%), 1 (1.1%), and 17 (19.1%) samples contained the dna of mycobacterium avium subsp. ... | 2014 | 24490931 |
| chronic hepatitis e virus infection: challenges in diagnosis and recognition in the united states. | 2015 | 24492403 | |
| management of hepatitis e virus (hev) zoonotic transmission: protection of rabbits against hev challenge following immunization with hev 239 vaccine. | hepatitis e virus (hev) constitutes a significant health burden worldwide, with an estimated approximately 33% of the world's population exposed to the pathogen. the recent licensed hev 239 vaccine in china showed excellent protective efficacy against hev of genotypes 1 and 4 in the general population and pregnant women. because hepatitis e is a zoonosis, it is also necessary to ascertain whether this vaccine can serve to manage animal sources of human hev infection. to test the efficacy of the ... | 2014 | 24498149 |
| hepatitis e virus seroprevalence in austrian adults: a nationwide cross-sectional study among civilians and military professionals. | hepatitis e virus (hev) infection is globally increasing. the present study was performed to investigate the hev seroprevalence, exposure risks as well as occupational risks for military personnel in austria, a central european country. | 2014 | 24498349 |
| seroprevalence of hepatitis e virus in domestic pigs and wild boars in switzerland. | hepatitis e is considered an emerging human viral disease in industrialized countries. studies from switzerland report a human seroprevalence of hepatitis e virus (hev) of 2.6-21%, a range lower than in adjacent european countries. the aim of this study was to determine whether hev seroprevalence in domestic pigs and wild boars is also lower in switzerland and whether it is increasing and thus indicating that this zoonotic viral infection is emerging. serum samples collected from 2,001 pigs in 2 ... | 2014 | 24499160 |
| rna-seq based transcriptome analysis of hepatitis e virus (hev) and hepatitis b virus (hbv) replicon transfected huh-7 cells. | pathogenesis of hepatitis b virus (hbv) and hepatitis e virus (hev) infection is as varied as they appear similar; while hbv causes an acute and/or chronic liver disease and hepatocellular carcinoma, hev mostly causes an acute self-limiting disease. in both infections, host responses are crucial in disease establishment and/or virus clearance. in the wake of worsening prognosis described during hev super-infection over chronic hbv hepatitis, we investigated the host responses by studying alterat ... | 2014 | 24505321 |
| high prevalence of hepatitis e virus in wild boar (sus scrofa) in yamaguchi prefecture, japan. | hepatitis e virus (hev) causes a food- and water-borne disease in humans, and japanese wild boar (sus scrofa leucomystax) meat is one of the most important sources of infection in japan. we tested 113 serum samples from wild boar captured in shimonoseki city, yamaguchi prefecture, japan from 2010 to 2012. serum samples were tested by enzyme-linked immunosorbent assay (elisa) using virus-like particles as antigen and nested reverse-transcription pcr (rt-pcr). anti-hev igg antibodies were detected ... | 2014 | 24506423 |
| food and environmental routes of hepatitis e virus transmission. | hepatitis e virus (hev), genus hepevirus, family hepeviridae is a main cause of epidemic hepatitis in developing countries and single cases of hepatitis in higher income countries. there are at least four hev genotypes which have different epidemiologic and clinical features. hepatitis e viruses are often transmitted via food and environmental routes. the actual role of these transmission routes in the spread of hev can depend on the virus genotype, the environmental conditions, the hygienic con ... | 2014 | 24513966 |
| hepatitis e virus infection results in acute graft failure after liver transplantation: a case report. | hepatitis e virus (hev) infection in most individuals is known as a self-limiting, acute, icteric hepatitis, but evidence shows hev is responsible for choric hepatitis and rapid progressed liver cirrhosis in immuno-compromised patients. we present the case of a patient whose diagnosis of acute graft failure was due to a hev infection 7 years after his first liver transplantation because of wilson's disease. the process showed severe jaundice with fatigue, poor appetite and continually rising ser ... | 2014 | 24518638 |
| the prevalence of hepatitis e virus infections among swine, swine farmers and the general population in guangdong province, china. | hepatitis e virus (hev) infection is widespread in china, but few studies have been carried out in guangdong province. this study aimed to characterize the prevalence of hev infections among swine, swine farmers and the general population in guangdong province. we conducted an epidemiological study that included swine, swine farmers and health examination attendees in guangdong from 2011 to 2013. the overall seroprevalence of anti-hev antibodies in swine was 64.7%. the results revealed that grow ... | 2014 | 24520348 |
| [primary risk factors of hepatitis e virus infection:a meta-analysis]. | to analyze the main risk factors of hepatitis e virus infection. | 2013 | 24529277 |
| an update on hepatitis b, d, and e viruses. | although newer and more effective treatments are now available for hepatitis c virus (hcv) infection, non-hcv viral hepatitis remains an important cause of liver disease, especially among hiv-infected individuals. hepatitis b virus (hbv) is the leading cause of cirrhosis worldwide, and approximately one-quarter of patients with cirrhosis develop decompensated liver disease within 5 years. initial treatment for chronic hbv infection includes peginterferon alfa, entecavir, and tenofovir. approxima ... | 2014 | 24531556 |
| method for hev detection in raw pig liver products and its implementation for naturally contaminated food. | it is now recognized that hepatitis e virus (hev) infection is not confined to developing countries. hev infection is a growing public health concern in industrialized countries where the disease is mainly autochthonous, caused by hev genotypes 3 and 4 and is today considered to be zoonotic. hev causes acute hepatitis in humans, predominantly through contamination of food and water. due to the low concentrations found in food and water samples, an efficient and rapid virus concentration method i ... | 2014 | 24553051 |
| severe bilateral amyotrophic neuralgia associated with major dysphagia secondary to acute hepatitis e. | several acute neurological syndromes can be triggered by immune events. hepatitis e virus (hev), an emerging infectious disease, can be one of these triggers. | 2013 | 24555112 |
| calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis e virus. | many recipients of organ transplants develop chronic hepatitis, due to infection with the hepatitis e virus (hev). although chronic hev infection is generally associated with immunosuppressive therapies, little is known about how different immunosuppressants affect hev infection. | 2014 | 24582714 |
| development of a vectored vaccine against hepatitis e virus. | hepatitis e virus is a non-enveloped ssrna virus [1] that causes human acute hepatitis through primarily fecal and oral transmission [2]. currently, no commercial hepatitis e (hev) vaccine is available. in the absence of an appropriate cell culture system for hev propagation, hev pseudocapsids (orf2 protein) have been produced either in escherichia coli or in insect cells and they have been shown to protect monkeys against virus challenge and to be effective in the prevention of natural hev infe ... | 2014 | 24583005 |
| hepatitis e virus: current concepts and future perspectives. | for many years, hepatitis e was considered a disease found only in certain developing countries. in these geographical settings, hepatitis e virus (hev) causes a self-limiting hepatitis in young adults, except in pregnant females, in whom the mortality is 25 %. our understanding of hev has changed radically in the past decade. it is now evident that hev is a threat to global health. this review article considers the current concepts and future perspectives of hev and its effects on human health, ... | 2014 | 24585215 |
| molecular detection of hepatitis e virus in rivers in the philippines. | to understand the hepatitis e virus (hev)-pollution status in the environment in the philippines, a total of 12 water samples were collected from rivers in manila city for detection of hev rna. three of 12 samples were positive for hev rna indicating that hev is circulating in the philippines. phylogenetic analysis classified all of the hev sequences into genotype 3. | 2014 | 24591433 |
| detection and localization of rabbit hepatitis e virus and antigen in systemic tissues from experimentally intraperitoneally infected rabbits. | rabbit hepatitis e virus (hev) is a novel genotype of hev, and is considered to pose a risk of zoonotic transmission. research into the systemic distribution of rabbit hev in rabbits during different periods of infection has rarely been reported. to better understand this virus, we infected rabbits with second-passage rabbit hev via an intraperitoneal route. after inoculation, the infection showed two types, temporary and constant infection. the detection of hev rna in the feces varied with time ... | 2014 | 24594631 |
| hev-orf3 encoding phosphoprotein interacts with hepsin. | hepatitis e virus (hev) is a major causative agent of acute clinical hepatitis in adults through much of asia, the middle east and africa. open reading frame 3 (orf3) encodes around 120 amino acids of phosphorylation protein that associates with the cytoskeleton, while its precise biological function is still unknown. | 2014 | 24596579 |
| persistent hepatitis e virus genotype 4 infection in a child with acute lymphoblastic leukemia. | in general, the hepatitis e virus (hev) causes acute, self-limiting hepatitis. prolonged and chronic infections caused by hev genotype 3 have been found in some immunosuppressed patients in developed countries. | 2014 | 24596581 |
| pregnant woman saved with liver transplantation from acute liver failure due to hepatitis e virus. | 2014 | 24606386 | |
| association of pregnancy outcome with cytokine gene polymorphisms in hev infection during pregnancy. | hepatitis e virus (hev) infection is associated with high maternal and fetal mortalities. the aim of the study was to find cytokine gene polymorphisms in relation to hev infection during pregnancy. a total of 262 pregnant and 208 non-pregnant women with hepatitis, 262 healthy pregnant and 208 non-pregnant women as controls. the study group were pregnant and non-pregnant women with hev infection, not infected with hev and controls. genotyping was carried out by pcr-rflp and arms-pcr methods. the ... | 2014 | 24610501 |
| pet veterinarians have no increased risk of hepatitis e compared to the general population. | the discovery of autochthonous hepatitis e in industrialized countries associated to genotype 3 has changed substantially the understanding about hepatitis e virus (hev) circulation. in these countries transmission has been associated to the consumption and direct contact to swine, a well-known reservoir for hev. more animal reservoirs for hev might exist since antibodies to hev have been detected in other animal species, such as dogs and cats. given the intimate contact between these pets and h ... | 2014 | 24610550 |
| withdrawn: seroepidemiology of hepatitis e virus in western iran. | the publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.bbr.2011.03.031. the duplicate article has therefore been withdrawn. | 2014 | 24613783 |
| past and current hepatitis e virus infection in renal transplant patients. | the chronic course of hepatitis e virus infection in immunosuppressed patients has been recently documented; however, clinical features and factors associated with this occurrence are not well known. the aim of this study was to evaluate the prevalence of previous or current hev infection in renal transplant patients. one hundred ninety-two kidney transplant patients were studied and classified in three groups: g1-infected with hepatitis b and/or c virus; g2-patients with elevated alt; g3-patien ... | 2014 | 24619955 |
| evidence of extrahepatic replication of hepatitis e virus in human placenta. | the incidence and severity of hepatitis e virus (hev) infection in pregnant women is high in developing countries. transplacental transmission of hev in the third trimester of pregnancy has been found to be associated with high fetal mortality. based on this evidence and in the absence of reports on hev replication in extrahepatic sites, this study was carried out to investigate if hev replication occurs in the placenta of infected mothers. the study included 68 acute viral hepatitis (avh) and 2 ... | 2014 | 24622580 |
| development of enzyme-linked immunosorbent assays using 2 truncated orf2 proteins for detection of igg antibodies against hepatitis e virus. | without appropriate culture systems for hepatitis e virus (hev), sufficient natural viral proteins are difficult to generate for use in serological tests. therefore, it is important to produce large amounts of hev recombinant proteins in an economical way. the present study developed elisas using 2 truncated forms of the hev open reading frame (orf) 2 protein in order to detect anti-hev igg in serum samples. | 2014 | 24624347 |
| complete genome sequence of swine hepatitis e virus prevalent in southwest china. | hepatitis e virus (hev) is an important public health concern in the world, especially in developing countries of africa and asia, including china. hepatitis e is recognized as a zoonotic disease, which is transmitted across species, including between humans and swine. hev is highly endemic in china, but the complete sequence of hev in southwestern china is lacking. swine hev strain km01 was isolated from a village in rural kunming, yunnan province, china, where swine are housed with humans. her ... | 2014 | 24625866 |
| analysis of helicase domain mutations in the hepatitis e virus derived from patients with fulminant hepatic failure: effects on enzymatic activities and virus replication. | fulminant hepatic failure (fhf) is the severe form of hepatitis e virus infection. virus sequence analyses from severe cases have shown presence of unique and highly conserved mutations in the helicase domain of genotype 1, 3 and 4 viruses. we evaluated role of two amino acid replacements (l1110f) and (v1120i); found to be frequent in genotype 1 fhf-e viruses from india. three mutant helicase proteins (two with single point mutations and one with dual mutations) were expressed in escherichia col ... | 2014 | 24630891 |
| rat hepatitis e virus derived from wild rats (rattus rattus) propagates efficiently in human hepatoma cell lines. | although rat hepatitis e virus (hev) has been identified in wild rats, no cell culture systems for this virus have been established. a recent report suggesting the presence of antibodies against rat hev in human sera encouraged us to cultivate rat hev in human cells. when liver homogenates obtained from wild rats (rattus rattus) in indonesia were inoculated onto human hepatocarcinoma cells, the rat hev replicated efficiently in plc/prf/5, huh-7 and hepg2 cells, irrespective of its genetic group ... | 2014 | 24631787 |
| phylogenetic demonstration of hepatitis e infection transmitted by pork meat ingestion. | hepatitis e virus (hev) is responsible for a small number of acute hepatitis in developed countries. in this setting, hev infection seems to be a zoonosis, although this has not been completely demonstrated. high morbidity and mortality associated with severe acute infections have been described, as well as the possible role of ribavirin therapy in those cases. we describe a case of acute hepatitis after pork meat ingestion in a patient with waldeström macroglobulinemia with immunoglobulin a def ... | 2015 | 24637729 |
| hepatitis e virus seroprevalence before hematopoietic sct: a pediatric experience. | 2014 | 24637901 | |
| ribavirin for chronic hepatitis e virus infection in transplant recipients. | there is no established therapy for hepatitis e virus (hev) infection. the aim of this retrospective, multicenter case series was to assess the effects of ribavirin as monotherapy for solid-organ transplant recipients with prolonged hev viremia. | 2014 | 24645943 |
| comparison of acute hepatitis e infection outcome in patients with and without chronic hepatitis b infection: a 10 year retrospective study in three regional hospitals in hong kong. | acute hepatitis e virus (hev) infection has recently become the commonest cause of acute viral hepatitis in hong kong (hk) with majority of hev belonging to genotype 4. studies from china have shown that acute hepatitis e patients with underlying chronic hepatitis b virus (hbv) infection may have a worse outcome than those without. in india where genotype 1 is more prevalent, superinfection with hepatitis e on patients with chronic liver disease including chronic hepatitis b infection can cause ... | 2014 | 24646686 |
| hepatitis e antibodies in laboratory rabbits from 2 us vendors. | we tested laboratory rabbits from 2 us vendors for antibodies against hepatitis e virus (hev); seroprevalences were 40% and 50%. retrospective analysis of an ocular herpes simplex 1 experiment demonstrated that hev seropositivity had no effect on experiment outcome. hev probably is widespread in research rabbits, but effects on research remain unknown. | 2014 | 24655426 |
| hepatitis e virus antibody prevalence in wildlife in poland. | hepatitis e is an important public health problem mostly in developing but occasionally also in industrialized countries. domestic and wildlife animals are considered reservoirs of the hepatitis e virus (hev). since no information on the prevalence of autochthonous hev infections in human and animal in poland is available, the aim of the study was to investigate the hev seroprevalence of different wildlife species as potential virus reservoirs in the country. no hev antibodies were found in any ... | 2015 | 24655475 |
| complete genome of hepatitis e virus from laboratory ferrets. | the complete genome of hepatitis e virus (hev) from laboratory ferrets imported from the united states was identified. this virus shared only 82.4%-82.5% nt sequence identities with strains from the netherlands, which indicated that the ferret hev genome is genetically diverse. some laboratory ferrets were contaminated with hev. | 2014 | 24655541 |
| autochthonous hepatitis e virus infections: a new transfusion-associated risk? | hepatitis e virus (hev) has been recognized since 2004 as a transfusion-transmissible infectious agent, and recent epidemiological data suggest that it may pose a safety threat to the blood supply. it has recently become obvious that hepatitis e is endemic in industrialized countries, and that more infections are autochthonous than travel-associated. epidemiological and phylogenetic analysis suggests that hev infection has to be considered as a zoonosis and that viral transmission from animals ( ... | 2014 | 24659945 |
| bacteria expressed hepatitis e virus capsid proteins maintain virion-like epitopes. | the protein encoded by orf2 in hepatitis e virus (hev) is the only capsid protein for this single-stranded rna virus. it was previously shown that 148 aa (aa 459-606) was needed for dimer formation, whereas 239 aa (aa 368-606) was necessary to form virus-like particles (vlps). the self-assembled vlps of p239 were characterized with a series of methods including high performance size-exclusion chromatography to demonstrate the particulate nature of purified and properly refolded p239. a neutraliz ... | 2014 | 24662711 |
| genetic host specificity of hepatitis e virus. | hepatitis e virus (hev) causes epidemic and sporadic cases of hepatitis worldwide. hev genotypes 3 (hev3) and 4 (hev4) infect humans and animals, with swine being the primary reservoir. the relevance of hev genetic diversity to host adaptation is poorly understood. we employed a bayesian network (bn) analysis of hev3 and hev4 to detect epistatic connectivity among protein sites and its association with the host specificity in each genotype. the data imply coevolution among ∼70% of polymorphic si ... | 2014 | 24667049 |
| light and darkness: prevalence of hepatitis e virus infection among the general population. | human hepatitis e virus (hhev) spreads early in life among the population in areas endemic for genotype 1 and infects mainly adults in areas endemic for genotype 3, where it would be responsible for about 10% of cases of suspected acute viral hepatitis of unknown etiology and for a number of subclinical, unrecognized infections. the overall prevalence of antibody to hhev is high in most of the former areas and low in most of the later ones, but wide regional differences have been recorded in bot ... | 2014 | 24672733 |
| development and validation of a genotype 3 recombinant protein-based immunoassay for hepatitis e virus serology in swine. | hepatitis e virus (hev) is classified within the family hepeviridae, genus hepevirus. hev genotype 3 (gt3) infections are endemic in pigs in western europe and in north and south america and cause zoonotic infections in humans. several serological assays to detect hev antibodies in pigs have been developed, at first mainly based on hev genotype 1 (gt1) antigens. to develop a sensitive hev gt3 elisa, a recombinant baculovirus expression product of hev gt3 open reading frame-2 was produced and coa ... | 2014 | 24676472 |
| hepatitis e seroprevalence among blood donors: a pilot study from western india. | hepatitis e virus (hev) is emerging as a potential threat to blood safety after several cases of transmission by transfusion or transplantation have been described. currently, blood donors in india are not screened for hev. the studies conducted on hev in recent times in india have focused on epidemiology and future perspectives, but there is no published study on blood donors. to address possible issues surrounding blood safety and risk of hev transmission within the indian blood supply, hev se ... | 2014 | 24678170 |
| seroprevalence of hepatitis e virus in pigs from different farming systems in the netherlands. | sporadic nontravel-related hepatitis e virus (hev) infections have been reported in industrialized countries. these infections are caused by zoonotic hev genotypes 3 and 4 that circulate in swine, wild boar, and deer. in the netherlands, hev rna has been detected in >50% of the pig farms, and hev-specific antibodies were detected in ∼70% of the slaughter pigs. in the current study, hev seroprevalences were investigated in pigs raised on conventional, free-range, and organic farms in the netherla ... | 2014 | 24680077 |
| induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis e virus. | virus-like particles (vlps) composed of the truncated capsid protein of swine hepatitis e virus (hev) were developed and immune responses of mice immunized with the vlps were evaluated. igg titers specific for the capsid protein of swine hev were significantly higher for all groups of mice immunized with the vlps than those of the negative control mice. splenocytes from mice immunized with the vlps also produced significantly greater quantities of interferon (ifn)-γ than interleukin (il)-4 and i ... | 2014 | 24690608 |
| prospective study of hepatitis e virus infection among pregnant women in france. | hepatitis e virus (hev) infection has a poor prognosis among pregnant women from high endemic countries. hev-prevalence and incidence among pregnant women is unknown in high-income countries such as france. this prospective study was conducted to assess hev infection in this setting. | 2014 | 24716485 |
| development of a blocking elisa for detection of antibodies against avian hepatitis e virus. | a blocking enzyme-linked immunosorbent assay (belisa) was developed for the detection of immunoglobulin g antibodies against avian hepatitis e virus (hev). in the belisa, the coating antigen was a truncated protein containing c-terminal 268-amino acid region of orf2 from an avian hev strain isolated in china (cahev) and blocking antibody was a monoclonal antibody (mab) 1h5 recognizing the epitope within amino acids 384-414 in the c-terminal 268-amino acid region. the concentration of blocking ma ... | 2014 | 24735599 |
| comparison of real-time pcr and antigen assays for detection of hepatitis e virus in blood donors. | hepatitis e virus (hev) infection is recognized as an emerging and often undiagnosed disease in industrialized countries, with asymptomatic infections actually occurring in blood donors. sensitive detection of hev-rna is crucial for diagnosis and monitoring of disease progression. we evaluated the analytical sensitivity and performance of three hev rt-pcr assays (realstar hev reverse transcription-pcr [rt-pcr], hepatitis@ceeramtools, and amplicube hev rt-pcr) for screening of individuals for hev ... | 2014 | 24740079 |
| seroprevalence of hepatitis e virus (hev) in humans living in high pig density areas of germany. | an increase in acute autochthonous hepatitis e virus (hev) infections has been recorded in germany. these are suspected to be zoonotically transmitted from wild boar, deer and domestic pig. the latter may represent a major reservoir for hev. in this study, 537 sera from humans living in westphalia and lower saxony, representing areas of high pig density in germany, were tested for the presence of hev-specific antibodies. among them were 302 individuals with occupational, direct contact to pigs a ... | 2014 | 24744181 |
| an orf1-rearranged hepatitis e virus derived from a chronically infected patient efficiently replicates in cell culture. | hepatitis e is an increasingly reported disease in industrialized countries. studies on the replication cycle of hepatitis e virus (hev) are hampered due to the lack of efficient and robust cell culture systems for this virus. we describe the successful isolation of hev derived from a chronically infected kidney transplant patient held under immunosuppressive therapy. inoculation of serum sample 47832 onto the human lung carcinoma cell line a549 resulted in the replication of the virus as shown ... | 2014 | 24750215 |
| detailed investigation of ongoing subclinical hepatitis e virus infections; occurring in outbreak settings of north india. | every year globally who reports 20 million hepatitis e virus (hev) infections. the disease occurs as sporadic cases or focused outbreaks and has potentials to cause massive epidemics. the reservoir of hev during inter-epidemic period is not well characterized. the sporadic cases usually lack history of contact with clinically overt hev patients. in the present context we evaluated the occurrence of subclinical hev as a possible reservoir in endemic region. | 2015 | 24750588 |
| myasthenia gravis associated with acute hepatitis e infection in immunocompetent woman. | 2014 | 24751295 | |
| molecular characterisation of human hepatitis e virus from italy: comparative analysis of five reverse transcription-pcr assays. | hepatitis e (hev) is an important public-health concern as a major cause of enterically transmitted hepatitis worldwide. in industrialised countries it is considered rare, and largely confined to travellers returning from endemic areas. however, autochthonous (locally acquired) hev infection is also emerging in these regions. the infection is caused by different genotypes, depending on whether it is travel-related or autochthonous. conventional rt-pcr followed by sequencing of pcr products can i ... | 2014 | 24755361 |
| hepatitis e infection in hiv-infected liver and kidney transplant candidates. | hepatitis e virus (hev) has been reported to cause acute and chronic hepatitis in those with hiv infection and among solid organ transplant recipients in europe. limited data indicate that hev is endemic in the united states, but the prevalence and significance of hev infection among those with hiv and awaiting solid organ transplantation is unknown. we evaluated anti-hev igm and igg antibodies and hev rna in 166 hiv-infected solid organ transplant candidates enrolled in the nih hiv-transplant c ... | 2014 | 24773782 |
| successful treatment of chronic hepatitis e after an orthotopic liver transplant with ribavirin monotherapy. | hepatitis e virus infection is increasingly reported as a cause of chronic hepatitis in organ transplant recipients. besides reduction of immunosuppressive therapy or pegylated-interferon therapy, promising results have been reported for ribavirin monotherapy of hepatitis e virus after kidney transplant. to our knowledge, this is the first report of a successful ribavirin monotherapy for chronic hepatitis e virus infection after and orthotopic liver transplant. | 2015 | 24779678 |
| phylogeography and phylodynamics of european genotype 3 hepatitis e virus. | hepatitis e virus is classified into four genotypes that have different geographical and host distributions. the main cause of sporadic autochthonous type e acute hepatitis in developed countries is genotype 3, which has a worldwide distribution and widely infects pigs. the aim of this study was to make hypotheses concerning the origin and global dispersion routes of this genotype by reconstructing the spatial and temporal dynamics of 208 hev genotype 3 orf-2 sequences (retrieved from public dat ... | 2014 | 24787998 |
| hepatitis e-associated encephalopathy in a renal transplant recipient. | hepatitis e virus genotype 3 is not rare in developed countries, and may cause chronic hepatitis in immunocompromised patients. this may not only lead to abnormalities in liver test and malaise, but to severe neurological symptoms as well. in this case, chronic hepatitis e infection caused encephalopathy, an atactic gait, lhermitte's sign, incomplete bladder emptying and peripheral sensory neuropathy in a renal transplant recipient. the diagnosis was not performed until years after the onset of ... | 2014 | 24789162 |
| bioaccumulation efficiency, tissue distribution, and environmental occurrence of hepatitis e virus in bivalve shellfish from france. | hepatitis e virus (hev), an enteric pathogen of both humans and animals, is excreted by infected individuals and is therefore present in wastewaters and coastal waters. as bivalve molluscan shellfish are known to concentrate viral particles during the process of filter feeding, they may accumulate this virus. the bioaccumulation efficiencies of oysters (crassostrea gigas), flat oysters (ostrea edulis), mussels (mytilus edulis), and clams (ruditapes philippinarum) were compared at different time ... | 2014 | 24795382 |
| hepatitis e virus (hev) protease: a chymotrypsin-like enzyme that processes both non-structural (porf1) and capsid (porf2) protein. | hepatitis e virus (hev), a major cause of acute viral hepatitis across the world, is a non-enveloped, plus-strand rna virus. its genome codes three proteins, porf1 (multifunctional polyprotein), porf2 (capsid protein) and porf3 (multi-regulatory protein). porf1 encodes methyltransferase, putative papain-like cysteine protease, helicase and replicase enzymes. of these, the protease domain has not been characterized. on the basis of sequence analysis, we cloned and expressed a protein covering aa ... | 2014 | 24795447 |
| transfusion-associated hepatitis before the screening of blood for hepatitis risk factors. | the true incidence of transfusion-associated hepatitis (tah) before blood screening is unknown. our aims were to reevaluate blood recipients receiving unscreened blood and analyze hepatitis viruses circulating more than 45 years ago. | 2014 | 24797372 |
| prevalence of hepatitis e virus infection in west bengal, india: a hospital-based study. | india is an endemic zone for hepatitis e virus (hev), which is associated with both epidemic and sporadic infections. in west bengal, only two hepatitis e outbreaks have been studied to date. however, sporadic cases of hev infection also occur during inter-epidemic periods. the aim of this hospital-based study was to detect the prevalence of hev infection in patients with acute sporadic hepatitis in west bengal, india. blood samples and clinical information were collected from 285 patients of bo ... | 2014 | 24821066 |
| current epidemiology of hepatitis e virus infection in the united states: low seroprevalence in the national health and nutrition evaluation survey. | analysis of the national health and nutrition evaluation survey (nhanes) 1988-1994 dataset found a relatively high seroprevalence (21%) of hepatitis e virus (hev) infection in the u.s. general population. using data obtained within the nhanes 2009-2010 survey, where a high performance assay for hev was used, we estimated the weighted seroprevalence of hev infection among u.s. individuals 6 years and older. we also evaluated factors associated with hev seropositivity. a total of 8,814 individuals ... | 2014 | 24824965 |
| subclinical circulation of avian hepatitis e virus within a multiple-age rearing and broiler breeder farm indicates persistence and vertical transmission of the virus. | in a prospective longitudinal study, a broiler breeder flock and its progeny were monitored for the presence of avian hepatitis e virus (hev) rna and antibodies. the flock was part of a multiple-age farm where the presence of avian hev with clinical signs (increased mortality and decreased egg production) was demonstrated in several previous production cycles. samples were taken twice at the rearing site and several times at the production site from broiler breeders including cockerels and day-o ... | 2014 | 24828493 |
| can hepatitis e virus be considered as an etiology of cryptogenic cirrhosis? | 2014 | 24829744 | |
| serological and molecular evidence of a plausible transmission of hepatitis e virus through pooled plasma. | recently, hepatitis e virus has been recognized as a new transfusion-associated risk; however, its efficiency of transmission through blood products requires further investigation. asymptomatic viremia of short duration has been observed in blood donors from several european countries to the rate of <1:10,000 and hev transmission in recipients of blood products has been documented in japan and europe. although hev rna was detected in large plasma fractionation pools used for manufacturing of pla ... | 2014 | 24830322 |
| hepatitis e virus genotype 4 in a pig farm, italy, 2013. | zoonotic strains of hepatitis e virus (hev) in europe have been reported to belong to genotypes 3 and 4. in 2012 and 2013, 57 pig farms in northern italy that had previously resulted seropositive for hev were surveyed for the presence of the virus, with positive samples subsequently genotyped. hepatitis e rna was identified in 17/57 (29·8%) seropositive farms. phylogenetic analysis demonstrated that distinct subtypes of genotype 3 were circulating in the north-east of italy; as well, for the fir ... | 2015 | 24831185 |
| enteric hepatitis viruses. | hepatitis viruses are infectious agents that can infect liver and cause inflammation. the infection triggers immune response against infected cells that leads to the destruction of hepatic cells. this destruction has two consequences: leaking alt and ast liver enzymes which increases during the course of disease and accumulation of bilirubin- a red pigmented compound released from dead red cells- which causes the yellow coloration of eyes and skin. these viruses transmit through diverse routes i ... | 2012 | 24834192 |
| protective immunity against hev. | rural community of dongtai city in eastern china is endemic for hepatitis e virus (hev), with the zoonotic genotype 4 virus predominating. the virus appears to be widely distributed in environment at generally low levels, such that infection is common, but >97% of which are asymptomatic and provoke a modest antibody response. naturally acquired immunity affords 75% protection against infection, prevents disease caused by primary infection and alleviates severity of the disease caused by the resi ... | 2014 | 24835679 |
| making the case for the development of a vaccination against hepatitis e virus. | hepatitis e virus (hev) infection is a global problem that affects 20 million individuals, and cause acute hepatitis in 3.5 million, with approximately 70,000 deaths worldwide per year. while the acute disease is generally self-limited, however, it may progress to fatal fulminant liver failure in certain individuals. contaminated water supplies disseminate this virus through the faecal-oral route, and swine is thought to be its zoonotic reservoir. attempts have been made to develop effective hev ... | 2015 | 24836400 |
| the relationship between socioeconomic indices and potentially zoonotic pathogens carried by wild norway rats: a survey in rhône, france (2010-2012). | leptospira interrogans, hantaviruses (particularly seoul virus), hepatitis e virus (hev), and toxoplasma gondii are rat-associated zoonoses that are responsible for human morbidity and mortality worldwide. this study aimed to describe the infection patterns of these four pathogens in wild rats (rattus norvegicus) across socioeconomic levels in neighbourhoods in lyon, france. the infection or exposure status was determined using polymerase chain reaction or serology for 178 wild rats captured in ... | 2014 | 24838220 |
| need for immunization against hepatotropic viruses in children with chronic liver disease. | infection with hepatotropic viruses is a common cause of acute deterioration and adverse outcome in children with chronic liver disease (cld). such superimposed infections may be preventable through vaccination. the present study aimed to evaluate the exposure rates of hepatitis a, b, and e viruses in children with cld and suggest an optimal vaccination strategy. | 2014 | 24840513 |
| establishment of culture systems for genotypes 3 and 4 hepatitis e virus (hev) obtained from human blood and application of hev inactivation using a pathogen reduction technology system. | it has been demonstrated that the hepatitis e virus (hev) can be transmitted via blood transfusion, and the risk of hev transmission via transfusion has become a major global concern. an hev culture system for blood-derived hev has been sought to obtain valuable knowledge of the virus and the risk of hev infection through blood products. | 2014 | 24845192 |
| a systematic review of hepatitis e virus infection in children. | a systematic review was conducted, seeking all literature relevant to the epidemiology, clinical and laboratory features, and outcome of hepatitis e virus (hev) infection in children. transmission is thought to be primarily from fecal-oral transmission, with the role of transmission from animal reservoirs not being clear in children. worldwide, seroprevalence is <10% up to 10 years of age, with the exception of 1 of 5 studies from india and the sole study from egypt. seroprevalence increases wit ... | 2014 | 24846637 |
| enhancement of interferon induction by orf3 product of hepatitis e virus. | hepatitis e virus (hev) causes both the endemic and epidemic spread of acute hepatitis in many parts of the world. hev open reading frame 3 (orf3) encodes a 13-kda multifunctional protein (vp13) that is essential for hev infection of animals. the exact role of vp13 in hev infection remains unclear. in this study, vp13 was found to enhance interferon (ifn) production induced by poly(i · c), a synthetic analog of double-stranded rna. poly(i · c) treatment induced a higher level of ifn-β mrna in he ... | 2014 | 24850742 |
| outbreak of hepatitis e in urban bangladesh resulting in maternal and perinatal mortality. | hepatitis e virus (hev) causes outbreaks of jaundice associated with maternal mortality. four deaths among pregnant women with jaundice occurred in an urban community near dhaka, bangladesh, in late 2008 and were reported to authorities in january 2009. we investigated the etiology and risk factors for jaundice and death. | 2014 | 24855146 |
| new hepatitis e virus genotype in camels, the middle east. | in a molecular epidemiology study of hepatitis e virus (hev) in dromedaries in dubai, united arab emirates, hev was detected in fecal samples from 3 camels. complete genome sequencing of 2 strains showed >20% overall nucleotide difference to known hevs. comparative genomic and phylogenetic analyses revealed a previously unrecognized hev genotype. | 2014 | 24856611 |
| hepatitis e virus infection, papua new guinea, fiji, and kiribati, 2003-2005. | 2014 | 24856799 |