Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| successful in utero treatment of fetal goitrous hypothyroidism: case report and review of the literature. | in this report, we present a case of fetal goiter with overdistended fetal neck and mild polyhydramnios. amniocentesis and cordocentesis were conducted at 32 weeks' gestation and fetal goitrous hypothyroidism was diagnosed. intra-amniotic injection of l-thyroxine (t4) was performed with a weekly dose of 150 microg four times between 33 and 36 weeks' gestation. in response to this in utero treatment, the goiter was reduced and polyhydramnios was improved. the mother gave birth to a healthy live m ... | 2006 | 16757912 |
| effects of hypothyroidism and endocrine disruptor-dependent non-thyroidal illness syndrome on the gnrh-gonadotroph axis of the adult male rat. | effects of primary hypothyroidism (hypo) on the male gonadal axis are controversial, with only scanty data on the gonadotroph cell response and no information on gnrh tuberoinfundibular neurons, even in animal models. hypo has been reported to variably induce hypogonadotropic hypogonadism, a hypergonadotropic state, or to have no effects on basal levels of pituitary gonadotropins, both in adult male rats and humans. similarly, the exogenous administration of gnrh to hypo rats and humans may incr ... | 2005 | 16760620 |
| estrogen effects on thyroid iodide uptake and thyroperoxidase activity in normal and ovariectomized rats. | sex steroids interfere with the pituitary-thyroid axis function, although the reports have been controversial and no conclusive data is available. some previous reports indicate that estradiol might also regulate thyroid function through a direct action on the thyrocytes. in this report, we examined the effects of low and high doses of estradiol administered to control and ovariectomized adult female rats and to pre-pubertal females. we demonstrate that estradiol administration to both intact ad ... | 2006 | 16762383 |
| t4-induced cardiac hypertrophy disrupts cyclic gmp mediated responses to brain natriuretic peptide in rabbit myocardium. | brain natriuretic peptide (bnp) affects the regulation of myocardial metabolism through the production of cgmp and these effects may be altered by cardiac hypertrophy. we tested the hypothesis that bnp would cause decreased metabolism and function in the heart and cardiac myocytes by increasing cgmp and that these effects would be disrupted after thyroxine-induced cardiac hypertrophy (t4). open-chest control and t4 rabbits were instrumented to determine local effects of epicardial bnp (10(-3) m) ... | 2006 | 16762459 |
| clinical presentation, quantitative sensory testing, and therapy of 2 patients with fourth thoracic syndrome. | the aim of the study was to describe 2 representative cases of patients presenting to an osteopathic pain practice with signs and symptoms consistent with the fourth thoracic (t4) syndrome. in addition, this article reports the application of quantitative thermosensory testing and dynamometer strength testing to confirm associated sensory and motor strength changes. nonmanipulative therapeutic interventions are reported for the first time. | 2006 | 16762670 |
| a novel hypothyroid dwarfism due to the missense mutation arg479cys of the thyroid peroxidase gene in the mouse. | recently, we found a novel dwarf mutation in an icr closed colony. this mutation was governed by a single autosomal recessive gene. in novel dwarf mice, plasma levels of the thyroid hormones, t3 and t4, were reduced; however, tsh was elevated. their thyroid glands showed a diffuse goiter exhibiting colloid deficiency and abnormal follicle epithelium. the dwarfism was improved by adding thyroid hormone in the diet. gene mapping revealed that the dwarf mutation was closely linked to the thyroid pe ... | 2006 | 16762971 |
| biomarkers of exposure and effects of environmental contaminants on swallows nesting along the rio grande, texas, usa. | we collected adult cave swallows (petrochelidon fulva) and cliff swallows (p. pyrrhonota) during the breeding seasons in 1999 and 2000 from eight locations along the rio grande from brownsville to el paso (unless otherwise specified, all locations are texas, usa) and an out-of-basin reference location. body mass, spleen mass, hepatosomatic index (hsi), gonadosomatic index (gsi), thyroxine (t4) in plasma, dna damage measured as the half-peak coefficient of variation of dna content (hpcv) in blood ... | 2006 | 16764476 |
| the persistent ddt metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, alters thyroid hormone-dependent genes, hepatic cytochrome p4503a, and pregnane x receptor gene expressions in atlantic salmon (salmo salar) parr. | the present study investigated the effects of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (dde) on the thyroid and steroid-metabolizing system in atlantic salmon (salmo salar) parr. fish were exposed to waterborne dde and thyroxine (t4), both singly and in combination, for 5 d. thyroid-stimulating hormone (tshbeta), t4 deiodinase (t4ord), thyroid receptors (tralpha and trbeta), and insulin-like growth factor type 1 receptor (igf-1r) were analyzed using quantitative (real-time) polymerase chain ... | 2006 | 16764480 |
| a clinical study of the effects of rocuronium in isoflurane-anaesthetized cats. | to evaluate the neuromuscular blocking and chronotropic effects of rocuronium bromide in cats anaesthetized for surgery. | 2006 | 16764586 |
| the turn of the screw: variations of the abundant beta-solenoid motif in passenger domains of type v secretory proteins. | many virulence factors of gram-negative bacteria are secreted by the type v secretion system via the autotransporter (at) and two-partner secretion (tps) pathways. at proteins effect their own secretion. they comprise three domains: the amino-terminal leader sequence; the secreted passenger domain; and the translocator domain that forms the secretory channel. in the tps pathway, the passenger and translocator domains are translated as separate proteins. in a previous publication, we proposed a b ... | 2006 | 16765057 |
| comparative genomic hybridization reveals genetic progression of oral squamous cell carcinoma from dysplasia via two different tumourigenic pathways. | to clarify the genetic pathway(s) involved in the development and progression of oral squamous cell carcinoma (oscc), as well as the relationship between genetic aberrations and biological characteristics of oscc tumours, comparative genomic hybridization was used to analyse genetic alterations in both primary osccs and adjacent dysplastic lesions of the same biopsy specimens from 35 patients. gain of 8q22-23 was the most frequent alteration in both oscc and mild dysplasia, and was considered th ... | 2006 | 16767698 |
| low dose interleukin-2 and 13-cis-retinoic acid as maintenance therapy in patients with solid tumors responsive to chemotherapy. | after aggressive surgery and chemotherapy, patients (pts) with advanced solid tumors have often an impaired immune function that may facilitate tumor relapse. we have demonstrated, in a phase ib study, that administering low-dose interleukin-2 (il-2) and 13-cis retinoic acid (ra), there was a significant improvement of the immune function, with low toxicity, in pts with advanced tumors that had been treated with aggressive surgery and chemotherapy (clin cancer res 7: 1251-1257, 2001). a further ... | 2003 | 16767920 |
| [case of cerebral venous thrombosis due to graves' disease with increased factor viii activity]. | a 39 year-old man was admitted to our hospital because of severe headache with fever continuing over two weeks. three days after admission he developed aphasia and right hemiparesis, when his ct revealed subarachnoid hemorrhage at the left sylvian fissure. he was diagnosed as suffering from cerebral venous thrombosis because empty delta sign was positive on the enhanced brain ct. suprasagittal sinus and bilateral transverse sinuses were not detected on the cerebral angiography. he was also diagn ... | 2006 | 16768094 |
| [case of graves' disease presenting only with rapid consciousness disturbance]. | a 79-year-old woman was admitted to our hospital because of forgetfulness for a month followed with rapid development of consciousness disturbance. after admission, the depressed consciousness level fluctuated but continued for more than a month. thyroid function tests showed increased free t3 and t4 level, lowered level of tsh, and increased anti-tsh receptor antibody titer. a diagnosis of graves' disease was made but we could find none of thyrotoxic manifestations such as goiter, exophthalmos, ... | 2006 | 16768098 |
| [supraglottic laryngectomy. still on-going]. | horizontal supraglottic laryngectomy (hsl) allows the preservation of a functioning larynx and avoids a permanent tracheostoma. its use and training have been conditioned by the employment of organ preservation programs and endoscopic laser surgery. | 2006 | 16768202 |
| effect of poly (2-methoxyethyl acrylate)-coated oxygenators on haemolysis. | blood contact with artificial device surfaces and mechanical trauma are two major factors for haemolysis. poly(2-methoxyethyl acrylate) (pmea) is an amphiphilic polymer with a polyethylene chain that is hydrophobic and a mildly hydrophilic tail. pmea coating has showed positive effects on protein adsorption, platelet loss, platelet aggregation and post-operative bleeding in previous studies. in this study, effects of poly(2-metoxyethyl acrylate) (pmea)-coated oxygenators on haemolysis was invest ... | 2006 | 16768295 |
| 35-year-old woman with progressive bilateral leg weakness. | a 35-year-old woman presented with one month's history of progressive bilateral leg weakness and altered sensation. there had been no pain. she had noted urinary frequency and constipation in the previous two weeks. on examination, the patient had diffuse lower extremity weakness (2-3/5), with a t6 sensory level to pain and temperature sensation. mri demonstrated a t4-5 intradural mass ventral to the spinal cord, with an enhancing dural tail, consistent with meningioma. at surgery an intradural, ... | 2006 | 16768759 |
| t4 gastric carcinoma: the benefit of non-curative resection. | the prognosis of patients with gastric carcinoma with invasion of the adjacent organs (t4 gastric carcinoma) is very poor. we evaluated the survival benefit of resection in this group of patients. | 2006 | 16768767 |
| genistein and other soya isoflavones are potent ligands for transthyretin in serum and cerebrospinal fluid. | consumption of soya-based nutrients is increasing in modern society because of their potentially protective effects against chronic diseases. soya products are also heavily advertised as alternative drugs for relief from symptoms of the menopause and for hormone replacement therapy. however, because of their oestrogenic activity, negative effects of isoflavones have been postulated. therefore, we analysed influences of soya isoflavones, major soya constituents with endocrine activity, on thyroxi ... | 2006 | 16768841 |
| composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy. | mutations in the cardiac ryanodine receptor (ryr2) gene have been reported to cause arrhythmogenic right ventricular cardiomyopathy (arvc). the molecular mechanisms by which genetic modifications lead to arvc are still not well understood. | 2006 | 16769042 |
| [a case of hormone-refractory prostate cancer (hrpc) with tumor fever responding to docetaxel plus prednisolone therapy]. | we have experienced a patient with tumor fever from hormone-refractory prostate cancer (hrpc) who was treated successfully using docetaxel plus prednisolone therapy. a 65-year-old male was diagnosed with prostate cancer (t4 n1 m1b). he received androgen-ablation therapy. but six months later he was confirmed to show failure of the previous hormone therapy and disease progression even after anti-androgen withdrawal. then docetaxel plus prednisolone therapy was started. after two courses of this t ... | 2006 | 16770110 |
| surgical outcome of t4a and resected t4b oral cavity cancer. | the american joint committee on cancer (ajcc) 2002 staging system (ajcc 2002) suggested that squamous cell carcinoma of the oral cavity (oscc) with t4b is unresectable. the current retrospective results show that selected t4b patients were resectable with favorable outcomes. | 2006 | 16770782 |
| bionanotube tetrapod assembly by in situ synthesis of a gold nanocluster with (gp5-his6)3 from bacteriophage t4. | 2006 | 16770820 | |
| [low t3 syndrome, low t4 syndrome (euthyroid sick syndrome)]. | 2006 | 16776201 | |
| [acute hemodynamic effects of intravenous diltiazem in patients with congenital heart defects and pulmonary hypertension post cardiac surgery]. | to observe the acute hemodynamic effects of intravenous diltiazem in patients with congenital heart defect (chd) and severe pulmonary hypertension (hp) post cardiac surgery. | 2006 | 16776949 |
| comparative evaluation between external phased array coil at 3 t and endorectal coil at 1.5 t: preliminary results. | the aim of this study was to compare the image quality and the diagnostic accuracy of endorectal coil 1.5 t mri (ermri) and phased-array coil 3 t mri (3-t mri) in the pretherapeutic staging of prostate cancer. | 2006 | 16778606 |
| metabolic and hemodynamic features of elderly patients undergoing beating heart coronary artery bypass graft surgery. | coronary artery bypass graft (cabg) surgery, nowadays, is increasingly performed in patients who are older and have more comorbidities than subjects operated on a decade ago. in this study, we investigated metabolic and hemodynamic features of elderly patients with single vessel coronary artery disease (cad), undergoing beating heart coronary artery bypass graft (bhcabg) surgery. | 2006 | 16778757 |
| thyroid hormone levels and psychological symptoms in sexually abused adolescent girls. | to explore the relationships between psychological symptoms and thyroid hormone levels in adolescent girls who had experienced the traumatic stress of sexual abuse. | 2006 | 16781773 |
| a selective barrier to horizontal gene transfer in the t4-type bacteriophages that has preserved a core genome with the viral replication and structural genes. | genomic analysis of bacteriophages frequently reveals a mosaic structure made up from modules that come from disparate sources. this fact has led to the general acceptance of the notion that rampant and promiscuous lateral gene transfer (lgt) plays a critical role in phage evolution. however, recent sequencing of a series of the t4-type phages has revealed that these large and complex genomes all share 2 substantial syntenous blocks of genes encoding the replication and virion structural genes. ... | 2006 | 16782763 |
| phase iii randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a gortec trial. | with the aim to increase the dose intensity of radiation therapy (rt), and subsequently the locoregional control rate, a very accelerated rt regimen was compared with conventional rt in a series of patients with head and neck squamous cell carcinoma (hnscc). | 2006 | 16782926 |
| comparative field performance over 3 years and two sites of transgenic wheat lines expressing hmw subunit transgenes. | a series of transgenic wheat lines expressing additional high molecular weight (hmw) subunit genes and the corresponding control lines were grown in replicate field trials at two uk sites (rothamsted research, approximately 50 km north of london and long ashton, near bristol) over 3 years (1998, 1999, 2000), with successive generations of the transgenic lines (t3, t4, t5) being planted. four plots from each site were used to determine grain dry weight, grain nitrogen, dough strength (measured as ... | 2006 | 16783593 |
| [spinal anesthesia in cesarean section with different combinations of bupivacaine and fentanyl]. | the use of opioids for spinal anesthesia increases the anesthetic quality, reduces side effects and also has advantages for the postoperative analgesia. the aim of this study was to evaluate the effects of subarachnoid %0.5 hyperbaric bupivacaine (b) alone or combined with 10 or 20 mg fentanyl (f) on the anesthetic properties for cesarean section and newborn. 45 patients were randomized to three groups to receive 1.8 ml anesthetic drug for spinal anesthesia. gi (n=15) received b, gii (n=15) 10 m ... | 2006 | 16783667 |
| prospective multicenter trial of staging adequacy in colon cancer: preliminary results. | lymph node evaluation is an important prognostic factor in colorectal cancer (crc). a 25% recurrence rate in patients with node-negative crc suggests that current staging practices are inadequate. focused analysis of the sentinel node (sn) by multiple sectioning and immunohistochemistry improves staging accuracy. | 2006 | 16785352 |
| rate of pathologic complete responses to docetaxel, cisplatin, and fluorouracil induction chemotherapy in patients with squamous cell carcinoma of the head and neck. | to report the rate of pathological complete response after induction chemotherapy with the docetaxel, cisplatin, and fluorouracil (tpf) combination. | 2006 | 16785415 |
| [transient neonatal hypothyrosis in premature neonates]. | plasma levels were measured of t4, free t4, t3, tsh in 64 premature neonates and in 41 those born at right time during the time-related course of the neonatal period. the results secured permit regarding the thyroid hypohormonosis syndrome in premature neonates as a consequence of the hypothalamic-hypophyseal-thyroid axis deficiency and of immaturity of the thyreostatic receptors as well. on the one hand, this promotes hypometabolism and, correspondingly, favours more economic utilization of bod ... | 2000 | 16786655 |
| phenotypic suppression by streptomycin of amber mutants in the ribonucleic acid bacteriophage coat protein cistron. | after mutagenesis with nitrosoguanidine or ultraviolet light, 298 streptomycin high-resistant and 98 streptomycin high-dependent mutants were isolated from hfrc su(-). they were tested for their ability to phenotypically suppress five different amber ribonucleic acid (rna) bacteriophage mutants in the presence of streptomycin. the phage mutants are all in the coat protein, which is 129 amino acids long; the uracil-adenine-guanine codons were at the following positions: sus3 and amb2, 6; amb11, 5 ... | 1969 | 16789101 |
| nonsense mutants in the rii a cistron of bacteriophage t4. | after in vitro treatment of bacteriophage t4 with hydroxylamine (ha), 54 nonsense mutants in the rii a cistron were isolated. these mutants were characterized by growth on suppressor strains of escherichia coli, and the mutational sites were mapped in the rii a cistron. twenty-five (9 sites) were amber (uag), 20 (6 sites) were opal (uga), and 9 (6 sites) were ochre (uaa). mapping experiments further indicated that there were three closely linked pairs of amber and opal mutations, conceivably inv ... | 1969 | 16789112 |
| restoration by chloramphenicol of bacteriophage production in escherichia coli b infected with a ligase-deficient amber mutant. | the addition of chloramphenicol (cm) 5 min after infection of the nonpermissive host escherichia coli b with the ligase-negative t4 amber, t4 amh39x, allowed replication of parental deoxyribonucleic acid (dna) and the production of high-molecular-weight progeny dna, composed mostly of subunits with a d(2)/d(1) of 0.6. when cm was removed after the accumulation of a large pool of this dna, most of the infected bacteria were able to produce viable progeny phage, with an average yield of approximat ... | 1969 | 16789114 |
| molecular recombination in t4 bacteriophage deoxyribonucleic acid: iii. formation of long single strands during recombination. | evidence was presented to support the hypothesis that long single strands appearing at late times (15 min after infection) are produced as a result of recombination and not as a continuous elongation during the replication process. the production of long strands does not depend on the multiplicity of infection, and the first long strands appear at the time when 20 to 50 phage equivalent units of deoxyribonucleic (dna) are synthesized, and not earlier. the addition of chloramphenicol at 5 min, wh ... | 1970 | 16789127 |
| new late gene, dar, involved in dna replication of bacteriophage t4 i. isolation, characterization, and genetic location. | suppressors of gene 59-defective mutants were isolated by screening spontaneous, temperature-sensitive (ts) revertants of the amber mutant, amc5, in gene 59. six ts revertants were isolated. no gene 59-defective ts recombinant was obtained by crossing each ts revertant with the wild type, t4d. however, suppressors of gene 59-defective mutants were obtained from two of these ts revertants. these suppressor mutants are referred to as dar (dna arrested restoration). dar mutants specifically restore ... | 1975 | 16789147 |
| homologous terminal sequences in the double-stranded rna genome segments of cytoplasmic polyhedrosis virus of the silkworm bombyx mori. | the 3'-terminal regions (20 to 32 residues) of the genome double-stranded rna (dsrna) segments of cytoplasmic polyhedrosis virus were sequenced. the dsrnas, which were labeled at their 3' termini by incubation with [5'-(32)p]pcp and t4 rna ligase, were denatured and resolved into the plus and minus strands by agarose-urea gel electrophoresis. ten single-stranded rnas thus obtained from the five dsrna segments iv, v, viii, ix, and x were sequenced by postlabeling methods. common 3'-terminal seque ... | 1982 | 16789232 |
| does marital status and marital status change predict physical health in older adults? | evidence for the effects of marital status and marital status change on physical health is equivocal. | 2006 | 16790081 |
| prrc-anticodon nuclease: functional organization of a prototypical bacterial restriction rnase. | the trna(lys) anticodon nuclease prrc is associated in latent form with the type ic dna restriction endonuclease ecoprri and activated by a phage t4-encoded inhibitor of ecoprri. the activation also requires the hydrolysis of gtp and presence of dttp and is inhibited by atp. the n-proximal ntpase domain of prrc has been implicated in relaying the activating signal to a c-proximal anticodon nuclease site by interacting with the requisite nucleotide cofactors [amitsur et al. (2003) mol. microbiol. ... | 2006 | 16790566 |
| esophageal cancer staging: the role of radiology. | in esophageal cancer staging, the radiologic approach is represented by tumor identification, preoperative staging, and re-staging after neoadjuvant therapies. at present, while barium radiography shows a high sensitivity for early and advanced tumors, endoscopy is always necessary for confirmation. ct and mri are the gold standard for preoperative staging of advanced (t4) esophageal cancer and for evaluation of distant metastasis; however they still show a low sensitivity in the study of possib ... | 2005 | 16792005 |
| hormonal regulation of mannan-binding lectin synthesis in hepatocytes. | activation of the complement system via the plasma protein mannan-binding lectin (mbl) provides a first line of defence against infections. the plasma level of mbl is, in part, determined genetically, but may also be influenced by different hormones in vivo. here we study the hormonal regulation of mbl synthesis from the human hepatocyte cell line huh-7. cells were exposed to medium with growth hormone (gh), hydrocortisone, insulin-like growth factor (igf)-1, insulin, interleukin (il)-6 or thyro ... | 2006 | 16792688 |
| the origin of the focal spike in musicogenic epilepsy. | to clarify the pathogenesis of a typical case of musicogenic epilepsy, we examined interictal spikes using the dipole tracing method (dtm). the patient was a 49-year-old, right-handed japanese man. he first experienced seizures at the age of 32 years; listening to his favorite piece of music frequently triggered them. his seizure type is partial (often complex, but sometimes simple). an interictal eeg examination revealed many focal spikes in f8 and t4. we estimated equivalent current dipoles (e ... | 2006 | 16793574 |
| the effects of sex-steroid administration on the pituitary-thyroid axis in transsexuals. | estrogen and androgen administration modulate the pituitary-thyroid axis through alterations in thyroid hormone-binding globulin (tbg) metabolism, but the effects of sex steroids on extrathyroidal thyroxine (t4) to triiodothyronine (t3) conversion in humans are unknown. | 2006 | 16793944 |
| transvaginal sonography as an adjunct to endorectal sonography in the staging of rectal cancer in women. | the purpose of this study was to evaluate the contribution of transvaginal sonography (tvs) in the staging of rectal cancer in women. | 2006 | 16794161 |
| [effects of cardiac sympathetic blockade on left ventricular diastolic function in patients with dilated cardiomyopathy and severe heart failure]. | to investigate the effects of cardiac sympathetic blockade on left ventricular diastolic function in patients with dilated cardiomyopathy and severe heart failure (hf). | 2006 | 16796856 |
| expression of human telomerase reverse transcriptase (htert) protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma in taiwan. | this study used an immunohistochemical technique to examine the expression of human telomerase reverse transcriptase (htert) protein in 82 specimens of oscc, 116 specimens of oral epithelial dysplasia (oed), and 21 specimens of normal oral mucosa (nom). the cytoplasmic and nuclear htert staining intensity (si; 0, no staining; 1, weak; 2, moderate; 3, strong), labeling indices (lis, defined as the percentage of positive cells in total cells), and labeling scores (lss, defined as li x si) in oscc, ... | 2007 | 16798059 |
| prognostic factors of squamous cell carcinoma of the anal margin treated by radiotherapy: the lyon experience. | to report our patient experience with squamous cell carcinoma of the anal margin and to evaluate the prognostic factors influencing outcome. | 2007 | 16799791 |
| late toxicity in complete response cases after definitive chemoradiotherapy for esophageal squamous cell carcinoma. | we retrospectively investigated long-term toxicity after concurrent chemoradiotherapy (crt) for patients with esophageal squamous cell carcinoma (escc). | 2006 | 16799883 |
| an alternative clamp loading pathway via the t4 clamp loader gp44/62-dna complex. | in bacteriophage t4, a clamp loading pathway that utilizes the t4 clamp loader (gp44/62) and atp hydrolysis initially to form a complex with the clamp (gp45) has been demonstrated, followed by interaction with dna and closing of the clamp. however, the recent observation that gp45 exists as an opened form in solution raises the possibility of other pathways for clamp loading. in this study, an alternative clamp loading sequence is evaluated in which gp44/62 first recognizes the dna substrate and ... | 2006 | 16800623 |
| single-molecule investigation of the t4 bacteriophage dna polymerase holoenzyme: multiple pathways of holoenzyme formation. | in t4 bacteriophage, the dna polymerase holoenzyme is responsible for accurate and processive dna synthesis. the holoenzyme consists of dna polymerase gp43 and clamp protein gp45. to form a productive holoenzyme complex, clamp loader protein gp44/62 is required for the loading of gp45, along with mgatp, and also for the subsequent binding of polymerase to the loaded clamp. recently published evidence suggests that holoenzyme assembly in the t4 replisome may take place via more than one pathway [ ... | 2006 | 16800624 |
| ossification of the proximal thoracic ligamenta flava causing acute myelopathy in a caucasian: case report and literature review. | case report and literature review. | 2007 | 16801933 |
| preoperative noninvasive eus evaluation in patients with esophageal cancer considered for esophagectomy. | worldwide, esophageal cancer ranks fifth in the mortality rate regarding tumor locations. eus is an essential tool in the evaluation of these patients allowing accurate staging and permitting stratified treatment options. aim. we have studied prospectively the impact of eus in the evaluation and decision for therapy of patients with esophageal cancer diagnosed in our center. | 2006 | 16802008 |
| gingival squamous cell carcinoma: diagnostic delay or rapid invasion? | the similarity between gingival squamous cell carcinoma (gscc) and more common periodontal lesions may lead to a delay in diagnosis or misdiagnosis. neoplastic lesions of gingival tissues are frequently diagnosed at an advanced stage. | 2006 | 16805687 |
| which thyroid-stimulating hormone level should be sought in hypothyroid patients under l-thyroxine replacement therapy? | we sought to determine whether relationships exist between level of thyroid-stimulating hormone (tsh) suppression and cardiovascular risk parameters such as plasma homocysteine, c-reactive protein (crp), fibrinogen, d-dimer and serum cholesterol in patients taking l-thyroxine-replacement therapy (lt4-rt). four hundred and two hypothyroid patients under lt4-rt were cross-sectionally evaluated. patients were grouped according to their achieved tsh (miu/l) levels under lt4-rt on an arbitrary manner ... | 2006 | 16805747 |
| sensory blockade after thoracic paravertebral injection of ropivacaine or bupivacaine. | no clinical trials comparing the characteristics of sensory blockade caused by various local anaesthetics in thoracic paravertebral blockade have been published. the aim of this prospective study was a clinical assessment of sensory blockade after paravertebral injection of ropivacaine or bupivacaine in patients undergoing modified radical mastectomy. | 2006 | 16805930 |
| pacap 38 as a modulator of immune and endocrine responses during lps-induced acute inflammation in rats. | the effect of pacap 38 administration on neuroendocrine and immune parameters was examined in rats with lps-induced peritonitis. treatment with pacap 38 alone did not influence the serum level of the cytokines and hormones examined, but significantly decreased immune cell activity. when administered together with lps, pacap 38 reversed its effect on immune and humoral parameters, causing a decrease in the serum concentrations of tnfalpha and corticosterone, and an increase in t4 and gh. the majo ... | 2006 | 16806497 |
| the problem of exogenous subclinical hyperthyroidism. | over the past two decades a plethora of publications and clinical practice data have established that subclinical thyroid dysfunction is a common condition occurring much more frequently than the overt expression of thyroid disease. subclinical hypothyroidism is considered to be the most common of these entities. however, far more common and relatively less studied is exogenous sublinical hyperthyroidism (subhyper) caused by l-thyroxine (t4) administration to thyroidectomized or hypothyroid pati ... | 2006 | 16807224 |
| mechanistic coupling of bacteriophage t4 dna packaging to components of the replication-dependent late transcription machinery. | regulation of the terminal stage of viral dna development, dna packaging, is poorly understood. a new phage t4 in vitro dna packaging assay employed purified proheads, terminase (gp17 + gp16), and atp to encapsidate dna resistant to nuclease. mature phage t4 dna and linearized plasmid dnas containing or lacking a cloned t4 gene were packaged with high (approximately 10%) efficiency. supercoiled, relaxed covalently closed, and nicked circular plasmid dnas were packaged inefficiently, if at all, b ... | 2006 | 16807240 |
| the colloidal thyroxine (t4) ring as a novel biomarker of perchlorate exposure in the african clawed frog xenopus laevis. | the purpose of this study was to determine if changes in colloidal thyroxine (t(4)) immunoreactivity can be used as a biomarker of perchlorate exposure in amphibian thyroid tissue. larval african clawed frogs (xenopus laevis) were exposed to 0, 1, 8, 93, and 1131 microg perchlorate/l for 38 and 69 days to cover the normal period of larval development and metamorphosis. the results of this study confirmed the presence of an immunoreactive colloidal t(4) ring in thyroid follicles of x. laevis and ... | 2006 | 16807283 |
| correlation between protein binding strength on immobilized metal affinity chromatography and the histidine-related protein surface structure. | immobilized metal affinity chromatography (imac) was investigated for its ability to characterize the histidine-related surface structure of a protein, that is, a histidine residue's surface accessibility and its potential involvement in intramolecular interactions. t4 lysozyme was chosen as the model protein. seven amino acid sites were selected on the basis of their relative surface accessibility, and they were substituted with histidine via site-directed protein mutagenesis to generate seven ... | 2006 | 16808452 |
| genetic diversity of acanthamoeba isolated from ocean sediments. | genetic diversity of 18 acanthamoeba isolates from ocean sediments was evaluated by comparing mitochondrial (mt) dna rflp, 18s rdna sequences and by examining their cytopathic effects on human corneal epithelial cells versus reference strains. all isolates belonged to morphologic group ii. total of 16 restriction phenotypes of mtdna from 18 isolates demonstrated the genetic diversity of acanthamoeba in ocean sediments. phylogenetic analysis using 18s rdna sequences revealed that the 18 isolates ... | 2006 | 16809959 |
| locally advanced prostate cancer treated with concomitant radiation and 5-fluorouracil: southwest oncology group study 9024. | radiation is considered the standard treatment for locally advanced (t3 and t4) prostate cancer but cure with radiation alone is infrequent. studies have shown that adding androgen ablation improves the results but there is still much room for improvement. we performed a phase ii multi-institutional study to explore the feasibility of concomitant chemoradiotherapy. | 2006 | 16813886 |
| a phase ii study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer. | the aim of this study was to evaluate the efficacy and tolerance of preoperative chemoradiotherapy (crt) with irinotecan (cpt-11) and 5-fluorouracil (5-fu) in patients with resectable rectal cancer. | 2006 | 16814947 |
| the effects of age, season and geographic region on thyroid hormones in steller sea lions (eumetopias jubatus). | the purpose of this study was to investigate thyroid hormone concentrations, thyroxine (t4) and triiodothyronine (t3), in order to determine basal levels in steller sea lions of different ages and over seasons. serum concentrations of total t4 were highest in steller sea lions followed by total t3 concentrations. concentrations of free t4 and free t3 were three to four orders of magnitude lower. concentrations for all four thyroid hormone measurements tended to a lower level as animals matured b ... | 2006 | 16815718 |
| influence of daily consumption of probiotic and conventional yoghurt on the plasma lipid profile in young healthy women. | a number of studies have found conflicting results concerning the modulation of plasma lipids induced by probiotics. therefore, the aim of this study was to verify and compare the effects of probiotic and conventional yoghurt on the plasma lipid profile of normocholesterolemic women. | 2006 | 16816529 |
| [comparative study on the resistance of bacteriophage phi chi 174d, t4 and f2 to an iodophor in laboratory]. | to screen for the most resistant bacteriophage as indicator in disinfection tests, the resistance of bacteriophage phi chi 174d, t4 and f2 to iodophor were observed in laboratory. | 2006 | 16816871 |
| does endoscopic ultrasound staging already allow individual treatment regimens in gastric cancer. | the aim of our study was to evaluate the accuracy of preoperative tnm staging with endoscopic ultrasound (eus) in gastric cancer patients in comparison with the pathohistological stage of the resected specimen, and to determine the possible implications of eus for individualized treatment of gastric cancer patients at our institution. | 2006 | 16817044 |
| [pituitary resistance to thyroid hormone--a case report]. | pituitary resistance to thyroid hormone is a very rare cause of hyperthyroidism. it is characterized by normal, or elevated tsh concentration with high concentration of t3 and t4. here, we present a case of a 24-year-old woman who suffered from mild thyrotoxicosis and diffuse goiter for several years. she had elevated ft3 and ft4 with slightly elevated tsh concentration. pituitary adenoma was excluded as magnetic resonance imaging showed normal pituitary gland, alpha subunit was within normal ra ... | 2005 | 16817146 |
| prediction of gait outcome with the knee-ankle-foot orthosis with medial hip joint in patients with spinal cord injuries: a study using recursive partitioning analysis. | retrospective study of the degree of gait independence achieved by persons with spinal cord injury (sci) using knee-ankle-foot orthosis with a medial single hip joint (msh-kafo). | 2007 | 16819556 |
| electrostatic properties of promoter recognized by e. coli rna polymerase esigma70. | a comparative analysis of electrostatic patterns for 359 sigma70-specific promoters and 359 nonpromoter regions on electrostatic map of escherichia coli genome was carried out. it was found that dna is not a uniformly charged molecule. there are some local inhomogeneities in its electrostatic profile which correlate with promoter sequences. electrostatic patterns of promoter dnas can be specified due to the presence of some distinctive motifs which differ for different promoter groups and may be ... | 2006 | 16819795 |
| transactivation activity of thyroid hormone receptors in fish (conger myriaster) in response to thyroid hormones. | we previously isolated cdnas encoding conger eel (conger myriaster) thyroid hormone (th) receptors (trs). in the present study, we investigated the transactivation activities of conger eel trs treated with ths (3,3',5-triiodo-l-thyronine [t3], l-thyroxine [t4], and 3,3',5'-triiodo-l-thyronine [rt3]), or ligands and activators of other nuclear receptors. following transient transfection into the japanese eel (anguilla japonica) hepatocyte cell line hepa-e1, the conger eel trs (ctrs) showed th-dep ... | 2006 | 16820313 |
| [management of locally advanced prostatic adenocarcinoma in france. octave observational survey]. | to describe the management of patients with locally advanced prostate cancer in france and the changes in this management between 2000 and 2003. | 2006 | 16821343 |
| [the difference of larynx cancer stage evaluation between clinical and pathological examinations]. | comparison of stage larynx carcinoma and estimation of hazard dissemination lymph nodes in preoperative clinical and postoperative histological examination according to the tnm staging system. | 2006 | 16821535 |
| [relationship between body condition (back fat thickness and body condition scoring) and fertility in dairy cows (german black pied/hf)]. | it was the aim of this study to compare body condition scoring with ultrasonographic back fat thickness. additionally, the relationship between back fat thickness and fertility, milk yield, number of parity and stage of lactation in dairy cows was examined. body condition of 211 cows (german black pied/hf) was determined by means of ultrasonographic back fat thickness (bft) and body condition scoring (bcs). the bft and the bcs were measured at four different stages during the course of lactation ... | 2006 | 16821559 |
| changes in plasma hormones profile and liver function in cows naturally exposed to lead and cadmium around different industrial areas. | the present study was carried out to assess the endocrine status and liver function in adult cows reared in polluted environment around different industrial units in india. the effect on endocrine system was examined by determination of plasma level of thyroid hormones, thyroxin (t4) (n=269) and triidothyronin (t3) (n=269), stress hormone cortisol (n=266), and reproductive hormones such as estradiol (n=84) and progesterone (n=84) in cows (>3 years) reared around different polluted industrial and ... | 2007 | 16822533 |
| local migration promotes competitive restraint in a host-pathogen 'tragedy of the commons'. | fragmented populations possess an intriguing duplicity: even if subpopulations are reliably extinction-prone, asynchrony in local extinctions and recolonizations makes global persistence possible. migration is a double-edged sword in such cases: too little migration prevents recolonization of extinct patches, whereas too much synchronizes subpopulations, raising the likelihood of global extinction. both edges of this proverbial sword have been explored by manipulating the rate of migration withi ... | 2006 | 16823452 |
| virus dna translocation: progress towards a first ascent of mount pretty difficult. | virion dna molecules of large dsdna viruses are highly condensed. to pack the dna, an atp hydrolysis-powered motor translocates the dna into a preformed empty protein shell, the prohead. the icosahedral prohead has a special fivefold vertex, the portal vertex, where the translocation machinery acts. the portal vertex contains the portal protein, a gear-shaped dodecamer of radially disposed subunits with a central channel for dna entry. the symmetry mismatch between the fivefold symmetry of the s ... | 2006 | 16824089 |
| portal fusion protein constraints on function in dna packaging of bacteriophage t4. | architecturally conserved viral portal dodecamers are central to capsid assembly and dna packaging. to examine bacteriophage t4 portal functions, we constructed, expressed and assembled portal gene 20 fusion proteins. c-terminally fused (gp20-gfp, gp20-hoc) and n-terminally fused (gfp-gp20 and hoc-gp20) portal fusion proteins assembled in vivo into active phage. phage assembled c-terminal fusion proteins were inaccessible to trypsin whereas assembled n-terminal fusions were accessible to trypsin ... | 2006 | 16824092 |
| thyrotoxicosis presenting as hypokalaemic paralysis and hyperlactataemia in an oriental man. | a 35-year-old malaysian man presented with rapid onset of flaccid quadriparesis associated with nausea and vomiting. general blood tests revealed severe hypokalaemia (serum potassium 1.5 mmol/l) and hypophosphataemia (serum phosphate 0.29 mmol/l) as a potential cause of the flaccid paralysis. arterial blood gases showed mixed acid base disturbance of respiratory alkalosis and metabolic acidosis with hyperlactataemia. thyrotoxic periodic paralysis (tpp) was suspected as the underlying cause of th ... | 2006 | 16824287 |
| role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus. | the transport of 125i-labeled thyroxine (t4) from the cerebrospinal fluid (csf) into brain and choroid plexus (cp) was measured in anesthetized rabbit [0.5 mg/kg medetomidine (domitor) and 10 mg/kg pentobarbitonal sodium (sagatal) iv] using the ventriculocisternal (v-c) perfusion technique. 125i-labeled t4 contained in artificial csf was continually perfused into the lateral ventricles for up to 4 h and recovered from the cisterna magna. the %recovery of 125i-labeled t4 from the acsf was 47.2+/- ... | 2006 | 16825415 |
| thyroid function in depression. | studies on thyroid functions were performed on patients suffering from depression. thirty four cases of depression were studied for their thyroid function and showed a diminished level of t3 and t4 with concomitant rise in tsh (thyroid stimulating hormone) level. this work showed that depressive patients had been suffering from sub-hypothyroidism. | 2006 | 16827091 |
| plasticity of the gene functions for dna replication in the t4-like phages. | we have completely sequenced and annotated the genomes of several relatives of the bacteriophage t4, including three coliphages (rb43, rb49 and rb69), three aeromonas salmonicida phages (44rr2.8t, 25 and 31) and one aeromonas hydrophila phage (aeh1). in addition, we have partially sequenced and annotated the t4-like genomes of coliphage rb16 (a close relative of rb43), a. salmonicida phage 65, acinetobacter johnsonii phage 133 and vibrio natriegens phage nt-1. each of these phage genomes exhibit ... | 2006 | 16828113 |
| monitoring activated clotting time for combined heparin and aprotinin application: in vivo evaluation of a new aprotinin-insensitive test using sonoclot. | kaolin-based activated clotting time assessed by hemochron (hkact) is a clinical standard for heparin monitoring alone and combined with aprotinin during cardiopulmonary bypass (cpb). however, aprotinin is known to prolong not only celite-based but also kaolin-based activated clotting time. overestimation of activated clotting times implies a potential hazardous risk of subtherapeutic heparin anticoagulation. recently, a novel 'aprotinin-insensitive' activated clotting time test has been develop ... | 2006 | 16828293 |
| dynamics of bacteriophage t4 presynaptic filament assembly from extrinsic fluorescence measurements of gp32-single-stranded dna interactions. | in the bacteriophage t4 homologous recombination system, presynaptic filament assembly on single-stranded (ssdna) dna requires uvsx recombinase, uvsy mediator, and gp32 ssdna-binding proteins. gp32 exerts both positive and negative effects on filament assembly: positive by denaturing ssdna secondary structure, and negative by competing with uvsx for ssdna binding sites. uvsy is believed to help uvsx displace gp32 from the ssdna. to test this model we developed a real-time fluorescence assay for ... | 2006 | 16829679 |
| recombinant human thyroid-stimulating hormone is effective for radioiodine ablation of post-surgical thyroid remnants. | to investigate whether recombinant human thyroid-stimulating factor (rhtsh) is effective for the radiometabolic ablation of post-surgery thyroid remnants, using low doses of (131)i. | 2006 | 16829763 |
| the relationship of body composition, feed intake, and metabolic hormones for broiler breeder females. | three hundred twenty cobb 500 broiler breeder pullets at 21 wk of age were selected from a flock fed according to cobb breeder management guide specifications. one hundred sixty pullets at 21 wk of age were switched to ad libitum feeding, and the remaining 160 pullets continued to be control-fed. the pullets were photostimulated at 22 wk and maintained until 36.5 wk. plasma samples were obtained, bw was determined, and hens were killed for determination of body composition at the following perio ... | 2006 | 16830857 |
| immunoexpression of multidrug-resistance protein 2 and cyclooxygenase 2 in medullary thyroid carcinomas. | chemoresistance is due to the expression of multidrug-resistance proteins (mrps). cyclooxygenase 2 (cox2), a key enzyme in prostaglandins synthesis, upregulates mrp1. mrp1 is overexpressed in medullary thyroid carcinomas (mtcs), but it is not involved in resistance to doxorubicin and cisplatin, which are commonly used in mtc treatment. mrp2 is specifically involved in resistance to both chemotherapeutic agents, but no data exist on the expression of mrp2 and cox2 in mtc. | 2006 | 16831027 |
| american society of clinical oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. | to develop a clinical practice guideline for treatment of laryngeal cancer with the intent of preserving the larynx (either the organ itself or its function). this guideline is intended for use by oncologists in the care of patients outside of clinical trials. | 2006 | 16832122 |
| [neuropsychiatric outcome in patients with congenital hypothyroidism precautiously treated: risk factors analysis in a group of patients from tuscany]. | in order to avoid an excessive medical monitoring and to obtain more functional medical controls for the outcome of children with early treated congenital hypothyroidism, the results of a neurological and psychiatric follow-up performed in area pisana since 1990 are revised. this analysis gives some indications to get over the differences of the various methodological approaches and to get better rehabilitation treatment in respect to the individual needs. | 2006 | 16832334 |
| hypertonic saline solution increases cerebral perfusion pressure during clinical orthotopic liver transplantation for fulminant hepatic failure: preliminary results. | during orthotopic liver transplantation for fulminant hepatic failure, some patients may develop sudden deterioration of cerebral perfusion and oxygenation, mainly due to increased intracranial pressure and hypotension, which are likely responsible for postoperative neurological morbidity and mortality. in the present study, we hypothesized that the favorable effects of hypertonic saline solution (nacl 7.5%, 4 ml/kg) infusion on both systemic and cerebral hemodynamics, demonstrated in laboratory ... | 2006 | 16832556 |
| theoretical study of low-lying triplet states of aniline. | multireference complete active space self-consistent-field casscf(10,12)/ano and second-order perturbation theory ms-caspt2 calculations were performed to determine the vertical low-lying singlet and triplet states of aniline. the sequence of the seven lower lying triplet states is t1(1(3)a'), t2(1(3)a' '), t3(2(3)a'), t4(3(3)a'), t5(2(3)a' '), t6(4(3)a'), and t7(3(3)a' '). the 3(3)a', 4(3)a', and 3(3)a' ' states are assigned as 3s, 3py, and 3pz rydberg states, respectively, while other states c ... | 2005 | 16833336 |
| sturdier dna nanotubes via ligation. | dna nanotubes are crystalline self-assemblies of dna tiles approximately 10 nm in diameter that readily grow tens of micrometers in length. easy assembly, programmability, and stiffness make them interesting for many applications, but dna nanotubes begin to melt at temperatures below 40 degrees c, break open when deposited on mica or scanned by afm, and disintegrate in deionized water. these weaknesses can be traced to the presence of discontinuities in the phosphate backbone, called nicks. the ... | 2006 | 16834415 |
| clinical validity of proliferating cell nuclear antigen as an objective marker for evaluating biologic features in patients with untreated prostate cancer. | although gleason grading may be the most useful system for evaluating biological activity of untreated prostate cancer, lack of interobserver validity with gleason scores (gs) is an unsolved issue. in this study, the proliferating cell nuclear antigen labeling index (pcna li) in untreated prostate cancer was investigated in order to clarify the usefulness of supplemental and objective markers for evaluating the biologic features of prostate cancer. | 2006 | 16834658 |
| ntp technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) (cas no. 1746-01-6) in female harlan sprague-dawley rats (gavage studies). | dioxin toxic equivalency factor evaluation overview: polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (ahr). structurally related compounds that bind to the ahr and exhibit biological actions similar to tcdd are commonly referred to as "dioxin-like compounds" (dlcs). ambient human exposure to dlcs occurs through the ingestion of foods containin ... | 2006 | 16835633 |
| ntp technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (pcb 153) (cas no. 35065-27-1) in female harlan sprague-dawley rats (gavage studies). | dioxin toxic equivalency factor evaluation overview: polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (ahr). structurally related compounds that bind to the ahr and exhibit biological actions similar to tcdd are commonly referred to as "dioxin-like compounds" (dlcs). ambient human exposure to dlcs occurs through the ingestion of foods containin ... | 2006 | 16835634 |
| lower tsh and higher t4 levels are associated with current depressive syndrome in young adults. | the relationship of individual thyroid function indices to depression in those without a history of prior thyroid dysfunction is uncertain. | 2006 | 16836601 |