Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| erythritol is more effective than xylitol and sorbitol in managing oral health endpoints. | objective. to provide a comprehensive overview of published evidence on the impact of erythritol, a noncaloric polyol bulk sweetener, on oral health. methods. a literature review was conducted regarding the potential effects of erythritol on dental plaque (biofilm), dental caries, and periodontal therapy. the efficacy of erythritol on oral health was compared with xylitol and sorbitol. results. erythritol effectively decreased weight of dental plaque and adherence of common streptococcal oral ba ... | 2016 | 27635141 |
| in situ anabolic activity of periodontal pathogens porphyromonas gingivalis and filifactor alocis in chronic periodontitis. | porphyromonas gingivalis and filifactor alocis are fastidious anaerobic bacteria strongly associated with chronic forms of periodontitis. our understanding of the growth activities of these microorganisms in situ is very limited. previous studies have shown that copy numbers of ribosomal-rna precursor (pre-rrna) of specific pathogen species relative to genomic-dna (gdna) of the same species (p:g ratios) are greater in actively growing bacterial cells than in resting cells. the method, so-called ... | 2016 | 27642101 |
| antimicrobial effect of chlorhexidine on aggregatibacter actinomycetemcomitans biofilms associated with peri-implantitis. | background. this study aimed to assessthe antimicrobial effect of chlorhexidine (chx) on aggregatibacter actinomycetemcomitans biofilms isolated from subgingival plaque of peri-implantitis lesions. methods. thirteen patients requiring peri-implantitis treatment were consecutively selected and their subgingival biofilm was collected by inserting fine sterile paper points into peri-implant pockets for 15 seconds. a. actinomycetemcomitans was isolated from the subgingival biofilm and cultured. in t ... | 2016 | 27651884 |
| papillon-lefèvre syndrome: a series of five cases among siblings. | papillon-lefèvre syndrome is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and aggressively progressing periodontitis leading to premature loss of deciduous and permanent dentition. the etiopathogenesis of the syndrome is relatively obscure, and immunologic, genetic, or possible bacterial etiologies have been proposed. | 2016 | 27658951 |
| spirochaete flagella hook proteins self-catalyse a lysinoalanine covalent crosslink for motility. | spirochaetes are bacteria responsible for several serious diseases, including lyme disease (borrelia burgdorferi), syphilis (treponema pallidum) and leptospirosis (leptospira interrogans), and contribute to periodontal diseases (treponema denticola)(1). these spirochaetes employ an unusual form of flagella-based motility necessary for pathogenicity; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within the periplasmic space(2-11). the universal joint or hook that links the ... | 2016 | 27670115 |
| periodontal and inflammatory bowel diseases: is there evidence of complex pathogenic interactions? | periodontal disease and inflammatory bowel disease (ibd) are both chronic inflammatory diseases. their pathogenesis is mediated by a complex interplay between a dysbiotic microbiota and the host immune-inflammatory response, and both are influenced by genetic and environmental factors. this review aimed to provide an overview of the evidence dealing with a possible pathogenic interaction between periodontal disease and ibd. there seems to be an increased prevalence of periodontal disease in pati ... | 2016 | 27672291 |
| emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria. | oral cancer, primarily oral squamous cell carcinoma (oscc), continues to be a major global health problem with high incidence and low survival rates. while the major risk factors for this malignancy, mostly lifestyle related, have been identified, around 15% of oral cancer cases remain unexplained. in light of evidence implicating bacteria in the aetiology of some cancer types, several epidemiological studies have been conducted in the last decade, employing methodologies ranging from traditiona ... | 2016 | 27677454 |
| a fast method for defb1 - 44c/g snp genotyping in brazilian patients with periodontitis. | defensins are cationic antimicrobial peptides expressed in epithelial cells. such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. it has been suggested that they have a protective role in the oral cavity. this study evaluated the defb1 polymorphism in diabetic patients with or without periodontitis in comparison to healthy controls. | 2014 | 27688368 |
| severe generalized periodontitis in a patient with an aplastic anemia: a 5 year follow-up case report. | aplastic anemia is a hematological disorder characterized by pancytopenia. this case report presents a young patient with untreated periodontitis associated with hematological disorders, and cyclosporine therapy. during 2 consecutive days, periodontal therapy which consisted of nonsurgical therapy supplemented with an antibiotic treatment and antifibrinolytic therapy was performed. commercial microbiological pcr tests and periodontitis il-1 polymorphism risk test were performed. following the pe ... | 2015 | 27688398 |
| beneficial properties of probiotics. | probiotics are live microorganisms that can be found in fermented foods and cultured milk, and are widely used for the preparation of infant food. they are well-known as "health friendly bacteria", which exhibit various health beneficial properties such as prevention of bowel diseases, improving the immune system, for lactose intolerance and intestinal microbial balance, exhibiting antihypercholesterolemic and antihypertensive effects, alleviation of postmenopausal disorders, and reducing travel ... | 2016 | 27688852 |
| presence of serum ferritin before and after bariatric surgery: analysis in dentate and edentulous patients. | society has changed its own lifestyle, specially its eating habits and physical activities, leading to excessive weight and a sedentary behavior, which has contributed to obesity increase. bariatric surgery is the most effective treatment to obesity, allowing weight loss and its maintenance. however, it has been related high levels of iron deficiency after surgery. a person's nutritional status might be affected by total or partial tooth loss. the aim of this longitudinal prospective cohort stud ... | 2016 | 27695053 |
| a novel glycan modifies the flagellar filament proteins of the oral bacterium treponema denticola. | while protein glycosylation has been reported in several spirochetes including the syphilis bacterium treponema pallidum and lyme disease pathogen borrelia burgdorferi, the pertinent glycan structures and their roles remain uncharacterized. herein, a novel glycan with an unusual chemical composition and structure in the oral spirochete treponema denticola, a keystone pathogen of periodontitis was reported. the identified glycan of mass 450.2 da is composed of a monoacetylated nonulosonic acid (n ... | 2017 | 27696564 |
| treponema denticola, porphyromonas gingivalis, and tannerella forsythia induce cell death and release of endogenous danger signals. | the aim of this study was to analyze whether periodontopathogens induced inflammatory cell death and the release of diverse endogenous danger molecules in thp-1-derived macrophages. | 2017 | 27697692 |
| pg1058 is a novel multidomain protein component of the bacterial type ix secretion system. | porphyromonas gingivalis utilises the bacteroidetes-specific type ix secretion system (t9ss) to export proteins across the outer membrane (om), including virulence factors such as the gingipains. the secreted proteins have a conserved carboxy-terminal domain essential for type ix secretion that is cleaved upon export. in p. gingivalis the t9ss substrates undergo glycosylation with anionic lipopolysaccharide (a-lps) and are attached to the om. in this study, comparative analyses of 24 bacteroidet ... | 2016 | 27711252 |
| associations of toll-like receptor and β-defensin polymorphisms with measures of periodontal disease (pd) in hiv+ north american adults: an exploratory study. | polymorphisms in toll-like receptor (tlr) and β-defensin (defb) genes have been recognized as potential genetic factors that can influence susceptibility to and severity of periodontal diseases (pd). however, data regarding associations between these polymorphisms and pd are still scarce in north american populations, and are not available in hiv+ north american populations. in this exploratory study, we analyzed samples from hiv+ adults (n = 115), who received primary hiv care at 3 local outpat ... | 2016 | 27727278 |
| salivary periodontopathic bacteria in children and adolescents with down syndrome. | to assess and compare salivary periodontopathic bacteria between groups of down syndrome and non-down syndrome children and adolescents. | 2016 | 27727287 |
| bacteria in the apical root canals of teeth with apical periodontitis. | bacteria in the tooth root canal may cause apical periodontitis. this study examined the bacterial species present in the apical root canal of teeth with apical periodontitis. antibiotic sensitivity tests were performed to evaluate whether these identified bacterial species were susceptible to specific kinds of antibiotics. | 2016 | 27745799 |
| real-time pcr analysis of fungal organisms and bacterial species at peri-implantitis sites. | the potential role of fungal organisms and their co-aggregation with either periodontopathogens or opportunistic pathogens at peri-implantitis sites is unknown. the aim of the present study was to qualitatively/quantitatively analyze and correlate fungal organisms and bacterial species at peri-implantitis sites. | 2015 | 27747631 |
| associations between periodontal microbiota and death rates. | it is conceived that specific combinations of periodontal bacteria are associated with risk for the various forms of periodontitis. we hypothesized that such specificity is also related to human cause-specific death rates. we tested this hypothesis in a representative sample of the us population followed for a mean duration of 11 years and found that two specific patterns of 21 serum antibodies against periodontal bacteria were significantly associated with increased all-cause and/or diabetes-re ... | 2016 | 27748442 |
| comparison of two different sampling methods for subgingival plaque: subgingival paper points or mouthrinse sample? | the collection of subgingival plaque samples with paper points is time-consuming and accident-sensitive. however, the collection of saliva is simple and contains pathogens of all intraoral surfaces. the aim of this study is to investigate whether a sampling strategy with mouthrinse (mouthrinse sample [msp]; test) leads to results comparable with standard sampling method (multiple site test from the deepest pocket of each quadrant [mt4]; control). | 2017 | 27786617 |
| a novel rat model of polymicrobial peri-implantitis: a preliminary study. | peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. to the best knowledge of the authors, there are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known microbial biofilms observed in humans. the aim of this study is to develop a novel peri-implant rat model using an established model of polymicrobial periodontitis. | 2017 | 27786620 |
| morgellons disease: a filamentous borrelial dermatitis. | morgellons disease (md) is a dermopathy characterized by multicolored filaments that lie under, are embedded in, or project from skin. although md was initially considered to be a delusional disorder, recent studies have demonstrated that the dermopathy is associated with tickborne infection, that the filaments are composed of keratin and collagen, and that they result from proliferation of keratinocytes and fibroblasts in epithelial tissue. culture, histopathological and molecular evidence of s ... | 2016 | 27789971 |
| association of periodontitis with rheumatoid arthritis and atherosclerosis: novel paradigms in etiopathogeneses and management? | there is increasing documentation of a link between inflammatory periodontal disease affecting the supporting structure of teeth, rheumatoid arthritis, and coronary artery disease. periodontitis is initiated predominantly by gram-negative bacteria and progresses as a consequence of the host inflammatory response to periodontal pathogens. lipopolysaccharide, a cell wall constituent stimulates the production of inflammatory cytokines via the activation of signaling pathways perpetuating inflammato ... | 2010 | 27789992 |
| motility and ultrastructure of spirochaeta thermophila. | we analyze here for the first time the swimming behavior of a thermophilic, strictly anaerobic spirochete, namely spirochaeta thermophila using high temperature light microscopy. our data show that s. thermophila very rapidly can change its morphology during swimming, resulting in cells appearing nearly linear, in cells possessing three different spiral forms, and in cells being linear at one end and spiral at the other end. in addition cells can rapidly bend by up to 180°, with their ends comin ... | 2016 | 27790206 |
| risk of atrial fibrillation or flutter associated with periodontitis: a nationwide, population-based, cohort study. | to investigate the risk of atrial fibrillation or atrial flutter in patients with periodontitis (pd) in comparison with individuals without pd. | 2016 | 27798703 |
| inhibitory effect of enterococcus faecium wb2000 on volatile sulfur compound production by porphyromonas gingivalis. | volatile sulfur compounds (vscs) produced by oral anaerobes are the major compounds responsible for oral malodor. enterococcus faecium wb2000 is recognized as an antiplaque probiotic bacterium. in this study, the effect of e. faecium wb2000 on vsc production by porphyromonas gingivalis was evaluated, and the mechanism of inhibition of oral malodor was investigated. p. gingivalis atcc 33277 was cultured in the presence of four lactic acid bacteria, including e. faecium wb2000. subsequently, p. gi ... | 2016 | 27799940 |
| chaperone addiction of toxin-antitoxin systems. | bacterial toxin-antitoxin (ta) systems, in which a labile antitoxin binds and inhibits the toxin, can promote adaptation and persistence by modulating bacterial growth in response to stress. some atypical ta systems, known as tripartite toxin-antitoxin-chaperone (tac) modules, include a molecular chaperone that facilitates folding and protects the antitoxin from degradation. here we use a tac module from mycobacterium tuberculosis as a model to investigate the molecular mechanisms by which class ... | 2016 | 27827369 |
| chlorhexidine varnish implemented treatment strategy for chronic periodontitis: a clinical and microbial study. | the aim of the present study was to evaluate the short-term clinical and microbiological effect of chlorhexidine varnish when used as an adjuvant to scaling and root planing in the treatment of chronic periodontitis. | 2016 | 27829764 |
| sensitivity and specificity of subgingival bacteria in predicting preterm birth- a pilot cohort study. | preterm birth (ptb) increases the risk of adverse outcomes for new born infants. subgingival bacteria are implicated in causing ptb. the aim of the present study was to assess the accuracy of some subgingival gram positive and gram negative bacteria detected by routine lab procedures in predicting ptb. | 2016 | 27833518 |
| microbial profiles and detection techniques in peri-implant diseases: a systematic review. | to describe the microbial profiles of peri-implant diseases and the main detection methods. | 2016 | 27833735 |
| impact of different oral hygiene aids for the reduction of morning bad breath among dental students: a crossover clinical trial. | to assess and compare the effects of different oral hygiene procedures on the reduction of morning bad breath, plaque and gingival status in healthy subjects. | 2016 | 27857523 |
| cross-sectional evaluation of periodontal status and microbiologic and rheumatoid parameters in a large cohort of patients with rheumatoid arthritis. | this study evaluates periodontal conditions and microbiologic findings and their influence on rheumatologic disease parameters in patients with rheumatoid arthritis (ra). | 2017 | 27858553 |
| multilocus sequence analysis of phylogroup 1 and 2 oral treponeme strains. | more than 75 "species-level" phylotypes of spirochete bacteria belonging to the genus treponema reside within the human oral cavity. the majority of these oral treponeme phylotypes correspond to as-yet-uncultivated taxa or strains of uncertain standing in taxonomy. here, we analyze phylogenetic and taxonomic relationships between oral treponeme strains using a multilocus sequence analysis (mlsa) scheme based on the highly conserved 16s rrna, pyrh, reca, and flaa genes. we utilized this mlsa sche ... | 2017 | 27864174 |
| lyme disease spirochaete borrelia burgdorferi does not require thiamin. | thiamin pyrophosphate (thdp), the active form of thiamin (vitamin b1), is believed to be an essential cofactor for all living organisms(1,2). here, we report the unprecedented result that thiamin is dispensable for the growth of the lyme disease pathogen borrelia burgdorferi (bb)(3). bb lacks genes for thiamin biosynthesis and transport as well as known thdp-dependent enzymes(4), and we were unable to detect thiamin or its derivatives in bb cells. we showed that eliminating thiamin in vitro and ... | 2016 | 27869793 |
| [the relationship of molecular genetic markers with clinical signs and risk factors of periodontitis]. | the study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by porphyromonas gingivalis, prevotella intermedia and treponema denticola. pathological tooth mobility was associated with hypercolonization by p. intermedia and tannerella forsythensis. expression of il8, tnf-α, mmp8 and mmp9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing i ... | 2017 | 27876716 |
| structural and functional probing of porz, an essential bacterial surface component of the type-ix secretion system of human oral-microbiomic porphyromonas gingivalis. | porphyromonas gingivalis is a member of the human oral microbiome abundant in dysbiosis and implicated in the pathogenesis of periodontal (gum) disease. it employs a newly described type-ix secretion system (t9ss) for secretion of virulence factors. cargo proteins destined for secretion through t9ss carry a recognition signal in the conserved c-terminal domain (ctd), which is removed by sortase poru during translocation. here, we identified a novel component of t9ss, porz, which is essential for ... | 2016 | 27883039 |
| prevalence of periodontal pathogens as predictor of the evolution of periodontal status. | the aim of this study was to determine the relationship between the prevalence of porphyromonas gingivalis, its fima genotypes, aggregatibacter actinomycetemcomitans, tannerella forsythia, and treponema denticola and the evolution of periodontal health. in a longitudinal prospective study, samples of subgingival plaque were taken from 114 patients (37 with chronic periodontitis, 17 with gingivitis, and 60 periodontally healthy) in the course of a full periodontal examination. pcr was employed to ... | 2016 | 27888369 |
| high-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis. | periodontal disease (pd) is generated by microorganisms. these microbes can enter the general circulation causing a bacteraemia. the result can be adverse systemic effects, which could promote conditions such as cardiovascular disease. level a evidence supports that pd is independently associated with arterial disease. pd is a common chronic condition affecting the majority of americans 30 years of age and older. atherosclerosis remains the largest cause of death and disability. studies indicate ... | 2017 | 27899684 |
| a novel approach to probe host-pathogen interactions of bovine digital dermatitis, a model of a complex polymicrobial infection. | polymicrobial infections represent a great challenge for the clarification of disease etiology and the development of comprehensive diagnostic or therapeutic tools, particularly for fastidious and difficult-to-cultivate bacteria. using bovine digital dermatitis (dd) as a disease model, we introduce a novel strategy to study the pathogenesis of complex infections. | 2016 | 27908274 |
| the danger signal extracellular atp is an inducer of fusobacterium nucleatum biofilm dispersal. | plaque biofilm is the primary etiological agent of periodontal disease. biofilm formation progresses through multiple developmental stages beginning with bacterial attachment to a surface, followed by development of microcolonies and finally detachment and dispersal from a mature biofilm as free planktonic bacteria. tissue damage arising from inflammatory response to biofilm is one of the hallmark features of periodontal disease. a consequence of tissue damage is the release of atp from within t ... | 2016 | 27909688 |
| comparative analysis of motility and other properties of treponema denticola strains. | the periodontitis-associated pathogen treponema denticola is a spirochetal bacterium that swims by rotating its cell body like a corkscrew using periplasmic flagella. we compared physiologic and pathogenic properties, including motility, in four strains of t. denticola. phase-contrast microscopy showed differential motility between the strains; atcc 35404 showed the highest motility, followed by atcc 33521, and the remaining two strains (atcc 35405 and atcc 33520) showed the lowest motility. tra ... | 2017 | 27914958 |
| increasing n-butanol production with saccharomyces cerevisiae by optimizing acetyl-coa synthesis, nadh levels and trans-2-enoyl-coa reductase expression. | n-butanol can serve as an excellent gasoline substitute. naturally, it is produced by some clostridia species which, however, exhibit only limited suitability for industrial n-butanol production. the yeast saccharomyces cerevisiae would be an ideal host due to its high robustness in fermentation processes. nevertheless, n-butanol yields and titers obtained so far with genetically engineered yeast strains are only low. | 2016 | 27924150 |
| photoinactivation using visible light plus water-filtered infrared-a (vis+wira) and chlorine e6 (ce6) eradicates planktonic periodontal pathogens and subgingival biofilms. | alternative treatment methods for pathogens and microbial biofilms are required due to the widespread rise in antibiotic resistance. antimicrobial photodynamic therapy (apdt) has recently gained attention as a novel method to eradicate pathogens. the aim of this study was to evaluate the antimicrobial effects of a novel apdt method using visible light (vis) and water infiltrated infrared a (wira) in combination with chlorine e6 (ce6) against different periodontal pathogens in planktonic form and ... | 2016 | 27965635 |
| a dormant microbial component in the development of preeclampsia. | preeclampsia (pe) is a complex, multisystem disorder that remains a leading cause of morbidity and mortality in pregnancy. four main classes of dysregulation accompany pe and are widely considered to contribute to its severity. these are abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress, and inflammation. what is lacking, however, is an explanation of how these themselves are caused. we here develop the unifying idea, and the considerable evidence for it, ... | 2016 | 27965958 |
| evaluation of efficacy of photodynamic therapy as an adjunct to nonsurgical periodontal therapy in treatment of chronic periodontitis patients: a clinico-microbiological study. | photodynamic therapy (pdt) is a local noninvasive treatment modality without side effects caused by antibiotics. the aim of this study was to evaluate the efficacy of adjunctive use of pdt with scaling and root planing as compared with srp alone in the treatment of chronic periodontitis. | 2016 | 27966504 |
| comparative metagenomics reveals taxonomically idiosyncratic yet functionally congruent communities in periodontitis. | the phylogenetic characteristics of microbial communities associated with periodontitis have been well studied, however, little is known about the functional endowments of this ecosystem. the present study examined 73 microbial assemblages from 25 individuals with generalized chronic periodontitis and 25 periodontally healthy individuals using whole genome shotgun sequencing. core metabolic networks were computed from taxa and genes identified in at least 80% of individuals in each group. 50% of ... | 2016 | 27991530 |
| detection of porphyromonas gingivalis and treponema denticola in chronic and aggressive periodontitis patients: a comparative polymerase chain reaction study. | the detection frequency of porphyromonas gingivalis and treponema denticola in chronic periodontitis (cp) and aggressive periodontitis (agp) is not explored well in indian population. | 2016 | 27994415 |
| influence of sex hormone levels on gingival enlargement in adolescent patients undergoing fixed orthodontic therapy: a pilot study. | sex hormones may be a modifying factor in the periodontal disease pathogenesis. | 2016 | 27994419 |
| 1,2-diacylglycerol choline phosphotransferase catalyzes the final step in the unique treponema denticola phosphatidylcholine biosynthesis pathway. | treponema denticola synthesizes phosphatidylcholine through a licca-dependent cdp-choline pathway identified only in the genus treponema. however, the mechanism of conversion of cdp-choline to phosphatidylcholine remained unclear. we report here characterization of tde0021 (herein designated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to choline phosphotransferases that catalyze the final step of the highly conserved kennedy pathway for phosphatidylcholine synthesis ... | 2017 | 28009086 |
| crispr-mediated epigenome editing. | mounting evidence has called into question our understanding of the role that the central dogma of molecular biology plays in human pathology. the conventional view that elucidating the mechanisms for translating genes into proteins can account for a panoply of diseases has proven incomplete. landmark studies point to epigenetics as a missing piece of the puzzle. however, technological limitations have hindered the study of specific roles for histone post-translational modifications, dna modific ... | 2016 | 28018139 |
| an experimental model of peripheral vascular disease involving the intravenous injection of oral bacteria. | objective: the purpose of this study was to observe the direct effects of oral bacteria, such as porphyromonas gingivalis (pg) and treponema denticola (td), on the peripheral vasculature. materials and methods: beagles were directly injected (at various doses) with pg or td. each leg vein was exposed, ligated at proximal and distal sites, and then injected with bacteria diluted with sterile saline. the collected vascular tissue was examined microscopically, and samples of the vascular tissue and ... | 2016 | 28018496 |
| pseudomonas aeruginosa microcolonies in coronary thrombi from patients with st-segment elevation myocardial infarction. | chronic infection is associated with an increased risk of atherothrombotic disease and direct bacterial infection of arteries has been suggested to contribute to the development of unstable atherosclerotic plaques. in this study, we examined coronary thrombi obtained in vivo from patients with st-segment elevation myocardial infarction (stemi) for the presence of bacterial dna and bacteria. aspirated coronary thrombi from 22 patients with stemi were collected during primary percutaneous coronary ... | 2016 | 28030624 |
| self-regulated 1-butanol production in escherichia coli based on the endogenous fermentative control. | as a natural fermentation product secreted by clostridium species, bio-based 1-butanol has attracted great attention for its potential as alternative fuel and chemical feedstock. feasibility of microbial 1-butanol production has also been demonstrated in various recombinant hosts. | 2016 | 28031744 |
| in vitro effect of porphyromonas gingivalis methionine gamma lyase on biofilm composition and oral inflammatory response. | methanethiol (methyl mercaptan) is an important contributor to oral malodour and periodontal tissue destruction. porphyromonas gingivalis, prevotella intermedia and fusobacterium nucleatum are key oral microbial species that produce methanethiol via methionine gamma lyase (mgl) activity. the aim of this study was to compare an mgl knockout strain of p. gingivalis with its wild type using a 10-species biofilm co-culture model with oral keratinocytes and its effect on biofilm composition and infla ... | 2016 | 28033374 |
| gingival crevicular fluid periostin levels in chronic periodontitis patients following nonsurgical periodontal treatment with low-level laser therapy. | periostin is a matricellular protein highly expressed in periosteum, periodontal ligament and is essential for tissue integrity and maturation. it plays a role in collagen fibrillogenesis and is downregulated in periodontal disease. biostimulation utilizing low-level laser therapy (lllt) influences periodontal ligament fibroblast proliferation. this study was conducted with the objective of estimating periostin levels in chronic periodontitis (cp) patients following lllt as an adjunct to root su ... | 2016 | 28042273 |
| evaluation of bacteriological profile in the apical root segment of the patients with primary apical periodontitis. | apical periodontitis usually results from bacterial accumulation and contamination occurring in the root-canal system, and extending beyond the apical foramen to involve the periapical tissues. literature has a paucity of the studies that stress on the division and analysis of the pulp canal segments. the reason for this disparity might be the technique used for collecting the samples from the pulp canals. hence, we carried out the present study to evaluate the microbial flora in the apical part ... | 2017 | 28050984 |
| oil pulling for maintaining oral hygiene - a review. | oil pulling is a traditional folk remedy practiced in ancient india. it is believed to cure more than thirty systemic diseases when practiced regularly and as directed. due to occurrence of side effects to modern medicines and oral hygiene products, people are increasingly attracted towards complementary and traditional practices. oil pulling in addition to offering several oral health benefits has also beneficial effects on overall health. the present article attempts to review and discuss this ... | 2016 | 28053895 |
| oil pulling for maintaining oral hygiene - a review. | oil pulling is a traditional folk remedy practiced in ancient india. it is believed to cure more than thirty systemic diseases when practiced regularly and as directed. due to occurrence of side effects to modern medicines and oral hygiene products, people are increasingly attracted towards complementary and traditional practices. oil pulling in addition to offering several oral health benefits has also beneficial effects on overall health. the present article attempts to review and discuss this ... | 2016 | 28053895 |
| secretable small rnas via outer membrane vesicles in periodontal pathogens. | micrornas (mirnas) have been shown to be major regulators of eukaryotic gene expression. however, bacterial rnas comparable in size to eukaryotic mirnas (18-22 nucleotides) have received little attention. recently, a novel class of small rnas similar in size to mirnas (mirna-size, small rnas or msrnas) have also been found in several bacteria. like mirnas, msrnas are approximately 15 to 25 nucleotides in length, and their precursors are predicted to form a hairpin loop secondary structure. here, ... | 2017 | 28068479 |
| butyrate production under aerobic growth conditions by engineered escherichia coli. | butyrate is an important industrial platform chemical. although several groups have reported butyrate production under oxygen-limited conditions by a native producer, clostridium tyrobutylicum, and by a metabolically engineered escherichia coli, efforts to produce butyrate under aerobic growth conditions have met limited success. here, we constructed a novel butyrate synthetic pathway that functions under aerobic growth conditions in e. coli, by modifying the 1-butanol synthetic pathway reported ... | 2017 | 28089378 |
| assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study. | the diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. the aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. | 2017 | 28093069 |
| effects of periodontal treatment on primary sjȫgren's syndrome symptoms. | the aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (essdai) and subjective (esspri) indexes in patients with primary sjögren's syndrome (pss). twenty-eight female patients were divided into four groups: pss patients with or without chronic periodontitis (scp, sc, respectively), and systemically healthy patients with or without chronic periodonti ... | 2017 | 28099577 |
| sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in ldlrnull mice. | periodontal disease (pd) and atherosclerotic vascular disease (asvd) are both chronic inflammatory diseases with a polymicrobial etiology and have been epidemiologically associated. the purpose is to examine whether periodontal bacteria that infect the periodontium can also infect vascular tissues and enhance pre-existing early aortic atherosclerotic lesions in ldlrnull mice. mice were orally infected with intermediate bacterial colonizer fusobacterium nucleatum for the first 12 weeks followed b ... | 2017 | 28104616 |
| "association of periodontopathic anaerobic bacterial co-occurrence to atherosclerosis" - a cross-sectional study. | epidemiological studies have shown a link between periodontitis and atherosclerosis. hence the present study was chosen to assess the presence of eight anaerobic periodontal pathogens and their virulence genes in subgingival plaque (sgp) and atheromatous plaque (ap) of patients who underwent coronary artery bypass graft surgery (cabg). | 2017 | 28189829 |
| analysis of the expression of nlrp3 and aim2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth. | to detect the distribution and expression levels of the nucleotide-binding oligomerization domain-like receptor protein 3 (nlrp3) and the absent in melanoma 2 (aim2) inflammasomes in periapical lesions and to analyse the possible microbial stimuli outside of teeth. | 2017 | 28193569 |
| influence of glycemic control on the levels of subgingival periodontal pathogens in patients with generalized chronic periodontitis and type 2 diabetes. | this study evaluated the influence of glycemic control on the levels and frequency of subgingival periodontal pathogens in patients with type 2 diabetes mellitus (dm) and generalized chronic periodontitis (chp). | 2017 | 28198980 |
| microbiological and ammp-8 findings depending on peri-implant disease in patients undergoing supportive implant therapy. | the aim of this study was to evaluate microbiological findings and ammp-8 level of peri-implant mucositis (m) and peri-implantitis (p) in patients undergoing supportive implant therapy (sit). eighty-nine patients with 171 implants were included. the case definitions were as follows: m: ppd ≥4mm, bop; p: ppd≥4mm, bop, radiographic bone loss ≥3.5mm. samples of peri-implant sulcular fluid (pisf) were taken from all peri-implant pockets at each implant to detect periodontal pathogens using pcr and a ... | 2017 | 28274501 |
| the infectious etiology of alzheimer's disease. | inflammation is a part of the first line of defense of the body against invasive pathogens, and plays a crucial role in tissue regeneration and repair. a proper inflammatory response ensures the suitable resolution of inflammation and elimination of harmful stimuli, but when the inflammatory reactions are inappropriate it can lead to damage of the surrounding normal cells. the relationship between infections and alzheimer's disease (ad) etiology, especially late-onset ad (load) has been continuo ... | 2017 | 28294067 |
| the c- terminal region of the major outer sheath protein (msp) of treponema denticola inhibits neutrophil chemotaxis. | treponema denticola is an oral spirochete strongly associated with severe periodontal disease. a prominent virulence factor, the major outer sheath protein (msp), disorients neutrophil chemotaxis by altering the cellular phosphoinositide balance, leading to impairment of downstream chemotactic events including actin rearrangement, rac1 activation and akt activation in response to chemoattractant stimulation. the specific regions of msp responsible for interactions with neutrophils remain unknown ... | 2017 | 28296262 |
| clinical and microbiological efficacy of 4% garcinia mangostana l. pericarp gel as local drug delivery in the treatment of chronic periodontitis: a randomized, controlled clinical trial. | the aim of the present study was to assess the periodontal status of individuals and the presence of red complex microorganisms (rcm), such as treponema denticola (td), porphyromonas gingivalis, and tannerella forsythia in the subgingival tissues of periodontitis patients before and after the application of 4% mangostana gel (garcinia mangostana [mga]) as an adjunct to scaling and root planing (srp). | 2017 | 28321995 |
| reproducibility of a commercially available subgingival plaque sampling strategy and analysis strategy with oligonucleotide probes. | the aim was to evaluate the intra-test agreement of pooled samples from the deepest periodontal pocket of each quadrant with a commercially available test kit based on hybridization of 16s rrna. | 2017 | 28325127 |
| the risk reduction of recurrent periodontal pathogens of local application minocycline hcl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment. | the aim of this study was to evaluate the clinical and microbiological effects of local application minocycline hcl 2% gel, used as an adjunct to scaling and root planing (srp) for treatment of chronic periodontitis (cp). cp is an inflammation of periodontal tissue that is caused mainly by bacterial infection, where periodontal destruction such as loss of attachment and bone destruction occurred. | 2017 | 28331333 |
| microbial colonization at the implant-abutment interface and its possible influence on periimplantitis: a systematic review and meta-analysis. | the aim of this systematic review and meta-analysis was to evaluate the microbial colonization at the implant-abutment interfaces (iai) on bone-level implants and to identify possible association with peri-implant conditions. | 2017 | 28359872 |
| generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy. | the aim of this study was to determine the variations in periodontal parameters and microbiological composition in periodontal pockets at the baseline and 3 and 6 months post treatmentin patients with generalized aggressive periodontitis(gap) undergoing non surgical periodontal treatment combined with chlorhexidine and systemic antibiotics. medical and dental history was taken from 10 subjects, average age 30.6±2.7 years, diagnosed with gap. a non surgical periodontal treatment combined with 0.1 ... | 2016 | 28383606 |
| cadmium sulphide quantum dots with tunable electronic properties by bacterial precipitation. | we present a new method to fabricate semiconducting, transition metal nanoparticles (nps) with tunable bandgap energies using engineered escherichia coli. these bacteria overexpress the treponema denticola cysteine desulfhydrase gene to facilitate precipitation of cadmium sulphide (cds) nps. analysis with transmission electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy reveal that the bacterially precipitated nps are agglomerates of mostly quantum dots, with diameters th ... | 2016 | 28435671 |
| biomarkers and bacteria around implants and natural teeth in the same individuals. | this cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (picf)/gingival crevicular fluid (gcf) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. | 2017 | 28440740 |
| oral treponeme major surface protein: sequence diversity and distributions within periodontal niches. | treponema denticola and other species (phylotypes) of oral spirochetes are widely considered to play important etiological roles in periodontitis and other oral infections. the major surface protein (msp) of t. denticola is directly implicated in several pathological mechanisms. here, we have analyzed msp sequence diversity across 68 strains of oral phylogroup 1 and 2 treponemes; including reference strains of t. denticola, treponema putidum, treponema medium, 'treponema vincentii', and 'trepone ... | 2017 | 28453906 |
| effect of surgical periodontal treatment associated to antimicrobial photodynamic therapy on chronic periodontitis: a randomized controlled clinical trial. | this randomized controlled clinical trial evaluated the effects of an adjunctive single application of antimicrobial photodynamic therapy (apdt) in surgical periodontal treatment (st) in patients with severe chronic periodontitis (scp). | 2017 | 28498507 |
| putative periodontal pathogens in the subgingival plaque of sudanese subjects with aggressive periodontitis. | there has been limited study of the bacterial species associated with aggressive periodontitis (agp) in high-risk populations in africa. the aim of this study was to investigate and quantify the presence of four putative periodontal pathogens in the subgingival plaque of sudanese subjects with agp. a secondary aim was to investigate the effect of varying the detection threshold on the reported prevalence of the bacterial species investigated. | 2017 | 28499236 |
| simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases. | chronic prostatitis (cpr) and benign prostatic hyperplasia (bph) are complex inflammatory conditions for which etiologic determinants are still poorly defined. periodontitis is caused by subgingival colonizing bacteria in the oral cavity. the causal effect of periodontal disease on prostatic inflammation has not been established. the purpose of this study is to isolate oral pathogens from expressed prostatic secretions of patients with periodontal disease and cpr or bph. | 2017 | 28548883 |
| periodontal pathogens in the etiology of pancreatic cancer. | pancreatic cancer is the fourth leading cause of cancer-related deaths worldwide. chronic pancreatitis is frequently observed in patients with pancreatic cancer, and a significant relationship between orodigestive cancer-related deaths and chronic periodontitis has been detected. porphyromonas gingivalis, tannerella forsythia, and treponema denticola, collectively called the red complex, are the major pathogens responsible for chronic periodontitis and secrete peptidylarginine deiminase. anti-p. ... | 2017 | 28611978 |
| salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight. | nutrition and body weight are modifying factors for periodontitis. the purpose of this study was to quantify two molecules (ghrelin and chemerin), released in association with food intake and obesity, in periodontally healthy and diseased individuals with respect to different body mass categories. | 2017 | 28631313 |
| effects of photodynamic therapy in periodontal treatment: a randomized, controlled clinical trial. | to evaluate the effects of photodynamic therapy (pdt) in the nonsurgical treatment of chronic periodontitis. | 2017 | 28667678 |
| chronic periodontal disease, periodontal pathogen colonization, and an increased risk of precancerous gastric lesions. | the present study assessed the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions of gastric cancer (plgc) in a clinical setting. | 2017 | 28671506 |
| the association of periodontopathic bacteria levels in saliva and tongue coating with oral malodor in periodontitis patients. | to elucidate the association oral malodor with the levels of periodontopathic bacteria in saliva and tongue coating of periodontitis patients with oral malodor. | 2017 | 28674708 |
| infection and apoptosis associated with inflammation in periodontitis: an immunohistologic study. | evidence of increased apoptosis is observed in periodontitis and may be associated with destruction of the periodontal tissue caused by the increased cell death, with the release of danger signals and subsequent stimulation of the proinflammatory processes. however, the exact mechanisms associated with these processes remain unclear. this study aimed to investigate the presence of the periodontal pathogen treponema denticola, apoptosis, high mobility group box 1 as a damage-associated molecular ... | 2017 | 28686335 |
| periodontal microbioma and rheumatoid arthritis: the role of porhyromonas gingivalis. | rheumatoid arthritis is a disease, which can be described as an autoimmune response after molecular mimicry caused by infective agents. the current study aims at evaluating the correlation between rhematoid arthritis (ra) and periodontal disease (pd), with special attention to the microbioma detected in the gums. thirty-four patients with rd were recruited into the current study. among rheumatic parameters, rheumatoid factor (rf), anti-citrullinated protein antibody (ccp), hla-bdr1 and das28 wer ... | 2017 | 28691459 |
| functional biomarkers for chronic periodontitis and insights into the roles of prevotella nigrescens and fusobacterium nucleatum; a metatranscriptome analysis. | periodontitis is the most prevalent inflammatory disease worldwide and is caused by a dysbiotic subgingival biofilm. here we used metatranscriptomics to determine the functional shift from health to periodontitis, the response of individual species to dysbiosis and to discover biomarkers. | 2015 | 28721234 |
| effect of azithromycin on a red complex polymicrobial biofilm. | azithromycin has recently gained popularity for the treatment of periodontal disease, despite sparse literature supporting efficiency in treating periodontal bacterial biofilms. the aim of this study was to evaluate the effect of azithromycin on biofilms comprised of porphyromonas gingivalis, treponema denticola, and tannerella forsythia in comparison to an amoxicillin and metronidazole combination. p. gingivalis w50, t. denticola atcc35405, and t. forsythia atcc43037 grown under anaerobic condi ... | 2017 | 28748041 |
| prevalence of periodontal pathogens among italian patients with chronic periodontitis: a retrospective study on 2992 patients. | the aim of the present study was to evaluate the prevalence of some periodontal pathogens in italian adults with chronic periodontitis. | 2017 | 28757933 |
| effect of pranayama on ppar-γ, nf-κb expressions and red complex microorganisms in patients with chronic periodontitis - a clinical trial. | sudarshankriya pranayama is the control of breathing movements to regulate the energy flow throughout the body, which has shown to positively affect immune function, autonomic nervous system and psychologic-neuro pathways. the practice of pranayama has been proven to show several benefits such as reduction in stress levels, relieves anxiety and depression, increase in antioxidant levels, reduces insulin resistance and improves respiratory function. | 2017 | 28764300 |
| microbial profile comparisons of saliva, pooled and site-specific subgingival samples in periodontitis patients. | the purpose of this study was to compare microbial profiles of saliva, pooled and site-specific subgingival samples in patients with periodontitis. we tested the hypotheses that saliva can be an alternative to pooled subgingival samples, when screening for presence of periopathogens. | 2017 | 28800622 |
| microbiological response to periodontal therapy and multivariable prediction of clinical outcome. | this study assessed the microbiological effects of a 2-phase antimicrobial periodontal therapy and tested microbiological, clinical, and biological markers as prognostic indicators for clinical success. | 2017 | 28844191 |
| quantification by qpcr of pathobionts in chronic periodontitis: development of predictive models of disease severity at site-specific level. | currently, there is little evidence available on the development of predictive models for the diagnosis or prognosis of chronic periodontitis based on the qpcr quantification of subgingival pathobionts. our objectives were to: (1) analyze and internally validate pathobiont-based models that could be used to distinguish different periodontal conditions at site-specific level within the same patient with chronic periodontitis; (2) develop nomograms derived from predictive models. subgingival plaqu ... | 2017 | 28848499 |
| risk of superinfection in peri-implantitis after systemic broad spectrum antibiotics. | peri-implant disease has developed over the last few years as a complication that is often difficult to resolve. the disease process is mainly attributed to bacterial infection. proposed combined therapies use broad-spectrum antibiotics to halt its progression. a major associated risk is the undetected development of superinfections that are difficult to eradicate. a group of healthy individuals with advanced peri-implantitis (pi) were referred for evaluation due to severe, rapidly progressive b ... | 2017 | 28854287 |