Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| intervendor consistency and reproducibility of left ventricular 2d global and regional strain with two different high-end ultrasound systems. | we aimed to assess intervendor agreement of global (gls) and regional longitudinal strain by vendor-specific software after eacvi/ase industry task force standardization initiatives for deformation imaging. | 2017 | 27330151 |
| live attenuated borrelia burgdorferi targeted mutants in an infectious strain background protect mice from challenge infection. | borrelia burgdorferi, b. garinii, and b. afzelii are all agents of lyme disease in different geographic locations. if left untreated, lyme disease can cause significant and long-term morbidity, which may continue after appropriate antibiotic therapy has been administered and live bacteria are no longer detectable. the increasing incidence and geographic spread of lyme disease are renewing interest in the vaccination of at-risk populations. we took the approach of vaccinating mice with two target ... | 2016 | 27335385 |
| mra_1571 is required for isoleucine biosynthesis and improves mycobacterium tuberculosis h37ra survival under stress. | threonine dehydratase is a pyridoxal 5-phosphate dependent enzyme required for isoleucine biosynthesis. threonine dehydratase (ilva) participates in conversion of threonine to 2-oxobutanoate and ammonia is released as a by-product. mra_1571 is annotated to be coding for ilva in mycobacterium tuberculosis h37ra (mtb-ra). we developed a recombinant (kd) mtb-ra strain by down-regulating ilva. the growth studies on different carbon sources suggested reduced growth of kd compared to wild-type (wt), a ... | 2016 | 27353854 |
| acquisition of the yeast kluyveromyces marxianus from unpasteurised milk by a kefir grain enhances kefir quality. | kefir is a fermented milk beverage consumed for nutritional and health tonic benefits in many parts of the world. it is produced by the fermentation of milk with a consortium of bacteria and yeast embedded within a polysaccharide matrix. this consortium is not well defined and can vary substantially between kefir grains. there are little data on the microbial stability of kefir grains, nor on interactions between microbes in the grain and in the milk. to study this, a grain was split, with one h ... | 2016 | 27369085 |
| [isolation and characterization of a streptococcus suis serotype 9 from a wild cat]. | streptococcus suis (s. suis) is an emerging zoonotic pathogenic bacterium capable of infecting piglets and human and with sporadic infections in a variety of mammalian species. the aim of this study is to investigate the prevalence of s. suis in wild cats. | 2016 | 27373075 |
| mutations in nalc induce mexab-oprm overexpression resulting in high level of aztreonam resistance in environmental isolates of pseudomonas aeruginosa. | pseudomonas aeruginosa is an opportunistic pathogen with high resistance to a wide variety of antimicrobials. the multidrug resistance pump mexab-oprm promotes the efflux of various antibiotics, mostly when mutations accumulate in the transcriptional regulators mexr, nalc and nald, thereby causing mexab-oprm overexpression. in this work, a characterization of 50 p. aeruginosa isolates obtained from brazilian agricultural soils to determine the reasons of their resistance to aztreonam was done. t ... | 2016 | 27412168 |
| characterization of an evolved carotenoids hyper-producer of saccharomyces cerevisiae through bioreactor parameter optimization and raman spectroscopy. | an evolutionary engineering approach for enhancing heterologous carotenoids production in an engineered saccharomyces cerevisiae strain was used previously to isolate several carotenoids hyper-producers from the evolved populations. β-carotene production was characterized in the parental and one of the evolved carotenoids hyper-producers (sm14) using bench-top bioreactors to assess the impact of ph, aeration, and media composition on β-carotene production levels. the results show that with maint ... | 2016 | 27423881 |
| display of isknv orf086 protein on the surface of aeromonas hydrophila and its immunogenicity in chinese perch (siniperca chuatsi). | co-infection with infectious spleen and kidney necrosis virus (isknv) and aeromonas hydrophila is becoming ever more widespread in chinese perch (siniperca chuatsi) aquaculture industry, so that it's necessary to develop the combined vaccine against isknv and a. hydrophila disease. the surface display of heterologous on bacteria using anchoring motifs from outer membranes proteins has already been explored as an effective delivery system of viral antigens. in present study, the isknv orf086 gene ... | 2016 | 27436517 |
| variable-number tandem-repeat analysis of leptospiral dna isolated from canine urine samples molecularly confirmed to contain pathogenic leptospires. | objective to use variable-number tandem-repeat (vntr) analysis to determine the infecting serovar and strain for leptospiral dna isolated from canine urine samples confirmed through pcr testing to contain pathogenic leptospires and to evaluate the sensitivity and specificity of microscopic agglutination testing (mat) for identifying the infecting serogroup. design diagnostic survey and test evaluation. sample leptospiral dna isolated from urine samples from 98 dogs confirmed through pcr testing ... | 2016 | 27479284 |
| effect of shear stress on pseudomonas aeruginosa isolated from the cystic fibrosis lung. | chronic colonization of the lungs by pseudomonas aeruginosa is one of the major causes of morbidity and mortality in cystic fibrosis (cf) patients. to gain insights into the characteristic biofilm phenotype of p. aeruginosa in the cf lungs, mimicking the cf lung environment is critical. we previously showed that growth of the non-cf-adapted p. aeruginosa pao1 strain in a rotating wall vessel, a device that simulates the low fluid shear (ls) conditions present in the cf lung, leads to the formati ... | 2016 | 27486191 |
| coping with coping strategies: how distributed teams and their members deal with the stress of distance, time zones and culture. | the changing world of work is increasing demands on workers through greater need for flexibility in global collaboration. this multiple-case study uses a qualitative research approach to study context-specific job stressors and coping in ten geographically distributed work teams. results demonstrate the complex and dynamic nature of the stress-coping process and how coping strategies, adapted to manage stress-evoking uncertainty and ambiguity in distributed work, created secondary sources of psy ... | 2011 | 27486615 |
| re-emergence of h3n2 strains carrying potential neutralizing mutations at the n-linked glycosylation site at the hemagglutinin head, post the 2009 h1n1 pandemic. | seasonally prevalent h1n1 and h3n2 influenza a viruses have evolved by antigenic drift; this evolution has resulted in the acquisition of asparagine (n)-linked glycosylation sites (ngss) in the globular head of hemagglutinin (ha), thereby affecting the antigenic and receptor-binding properties, as well as virulence. an epidemiological survey indicated that although the traditional seasonal h1n1 strain had disappeared, h3n2 became predominant again in the seasons (2010-11 and 2011-12) immediately ... | 2016 | 27503338 |
| layer-specific analysis of dobutamine stress echocardiography for the evaluation of coronary artery disease. | although dobutamine stress echocardiography (dse) is a well-defined tool for the diagnosis of coronary artery disease (cad), false-negative and false-positive results still occur. this study investigated the diagnostic role of layer-specific analysis using 2-dimensional speckle-tracking echocardiography (ste) during dse.a total of 121 patients who underwent dse and showed normal wall motion and ejection fraction during baseline echocardiography were enrolled. all patients underwent coronary angi ... | 2016 | 27512879 |
| rapid identification of the receptor-binding specificity of influenza a viruses by fluorogenic glycofoldamers. | the re-emergence of influenza raises a global concern that viral pandemics can unpredictably occur. however, effective approaches that can probe the infection risk of influenza viruses for humans are rare. in this work, we develop a glycofoldamer that can rapidly identify the glycan-receptor specificity of influenza viruses in a high-throughput manner. the coupling of glycan receptors that can be recognized by hemagglutinin (a surface protein on the virion capsid of influenza) to a fluorogenic-d ... | 2016 | 27513450 |
| successful in vitro fertilization and generation of transgenics in black and tan brachyury (btbr) mice. | the black and tan brachyury (btbr) mouse strain is a valuable model for the study of long-term complications from obesity-induced type 2 diabetes mellitus and autism spectrum disorder. due to technical difficulties with assisted reproduction, genetically modified animals on this background have previously been generated through extensive backcrossing, which is expensive and time-consuming. we successfully generated two separate transgenic mouse lines after direct zygote microinjection into this ... | 2016 | 27515175 |
| characterization of a cadmium resistance lactococcus lactis subsp. lactis strain by antioxidant assays and proteome profiles methods. | heavy metal contamination poses a major threat to the environment and human health for their potential toxicity and non-biodegradable properties. at present, some probiotics bacteria are reported to have great potential to eliminate heavy metals from food and water. in this study, resistance properties of a newly isolated lactococcus lactis subsp. lactis for cadmium were studied by antioxidant assays and proteomics analysis. antioxidant capacity of this strain was significantly activated under c ... | 2016 | 27522548 |
| use of homologous recombination in yeast to create chimeric bovine viral diarrhea virus cdna clones. | the open reading frame of a brazilian bovine viral diarrhea virus (bvdv) strain, ibsp4ncp, was recombined with the untranslated regions of the reference nadl strain by homologous recombination in saccharomyces cerevisiae, resulting in chimeric full-length cdna clones of bvdv (chi-nadl/ibsp4ncp#2 and chi-nadl/ibsp4ncp#3). the recombinant clones were successfully recovered, resulting in viable viruses, having the kinetics of replication, focus size, and morphology similar to those of the parental ... | 2017 | 27522929 |
| synthetic genome engineering forging new frontiers for wine yeast. | over the past 15 years, the seismic shifts caused by the convergence of biomolecular, chemical, physical, mathematical, and computational sciences alongside cutting-edge developments in information technology and engineering have erupted into a new field of scientific endeavor dubbed synthetic biology. recent rapid advances in high-throughput dna sequencing and dna synthesis techniques are enabling the design and construction of new biological parts (genes), devices (gene networks) and modules ( ... | 2017 | 27535766 |
| proximal forearm extensor muscle strain is reduced when driving nails using a shock-controlled hammer. | repetitive hammer use has been associated with strain and musculoskeletal injuries. this study investigated if using a shock-control hammer reduces forearm muscle strain by observing adverse physiological responses (i.e. inflammation and localized edema) after use. | 2016 | 27542101 |
| effects of lactobacillus plantarum ccfm0236 on hyperglycaemia and insulin resistance in high-fat and streptozotocin-induced type 2 diabetic mice. | the aim of this study was to rapidly screen potential hypoglycaemic strain by α-glucosidase inhibitory activity in vitro, then explored the antidiabetic effect of lactobacillus plantarum ccfm0236 in vivo. | 2016 | 27552342 |
| the establishment and characteristics of cell-adapted ibv strain h120. | avian infectious bronchitis virus is an important pathogen in poultry worldwide. vaccination is the only effective way to prevent and control ibv infection. h120, one of the safest vaccine strains, which has been used worldwide as a primary vaccine, cannot adapt to passaged cells, which severely restricts the quality of the vaccine. based on the reverse genetics of our previous research work, we constructed the recombinant r-h120-beaudette-p65(s) strain by replacing the complete spike gene of h1 ... | 2016 | 27558123 |
| potential swimming motility variation by acrr in escherichia coli. | acrr, the toxic-compounds-response regulator, regulates motility in microorganisms, presumably to escape from toxic environments. in this study, the genome-wide target genes of acrr were investigated in a δacrr mutant strain by microarray analysis. in the absence of acrr, the transcription of most flagella/motility genes was highly increased. in addition, flagella formation was increased in this mutant strain. motility assays revealed that acrr modulates swimming motility, but not swarming. | 2016 | 27558437 |
| impact of area strain by 3d speckle tracking on clinical outcome in patients after acute myocardial infarction. | three-dimensional (3d) speckle tracking echocardiography (ste) has been developed to overcome the limitations of two-dimensional (2d) ste and has been applied in the several clinical settings. however, no data exist about the prognostic value of 3dste-based strain on clinical outcome after myocardial infarction (mi). this study was designed to investigate the prognostic value of area strain (as) by 3d speckle tracking in predicting clinical outcome after acute mi. | 2016 | 27558647 |
| bacterial quorum sensing stabilizes cooperation by optimizing growth strategies. | communication has been suggested as a mechanism to stabilize cooperation. in bacteria, chemical communication, termed quorum sensing (qs), has been hypothesized to fill this role, and extracellular public goods are often induced by qs at high cell densities. here we show, with the bacterium vibrio harveyi, that qs provides strong resistance against invasion of a qs defector strain by maximizing the cellular growth rate at low cell densities while achieving maximum productivity through protease u ... | 2016 | 27565619 |
| functional genomics using the saccharomyces cerevisiae yeast deletion collections. | constructed by a consortium of 16 laboratories, the saccharomyces genome-wide deletion collections have, for the past decade, provided a powerful, rapid, and inexpensive approach for functional profiling of the yeast genome. loss-of-function deletion mutants were systematically created using a polymerase chain reaction (pcr)-based gene deletion strategy to generate a start-to-stop codon replacement of each open reading frame by homologous recombination. each strain carries two molecular barcodes ... | 2016 | 27587784 |
| cloning, expression, and purification of pseudomonas aeruginosa flagellin, and characterization of the elicited anti-flagellin antibody. | pseudomonas aeruginosa is an important opportunistic human pathogen that causes serious infections in immunocompromised hosts. the single polar flagellum is an important factor in both virulence and colonization. | 2016 | 27621933 |
| vibrational stimulation induces osteoblast differentiation and the upregulation of osteogenic gene expression in vitro. | vibrational stimulation is an accepted non-invasive method used to improve bone remodeling. however, the underlying mechanisms of this phenomenon remain unclear. in this study, we developed a new vibration-loading system to apply vibrational stimulation to cells based on a previously reported in vivo study. we hypothesized that osteoblasts respond to vibrational strain by expressing osteogenic marker genes, such as alkaline-phosphatase (alp), runx2, and osterix. to test our hypothesis, we develo ... | 2016 | 27639712 |
| cholesterol remnants and triglycerides are associated with decreased myocardial function in patients with type 2 diabetes. | recently, genetic studies have suggested a causal relationship between cholesterol remnants and ischemic heart disease. we aimed to determine whether cholesterol remnants and its marker, triglyceride levels, are associated with cardiac function as determined by sensitive echocardiographic measures in a population of patients with type 2 diabetes. | 2016 | 27659241 |
| assessment of right ventricular strain by computed tomography versus echocardiography in acute pulmonary embolism. | right ventricular strain (rvs) identifies patients at risk of hemodynamic deterioration from pulmonary embolism (pe). our hypothesis was that chest computed tomography (ct) can provide information about rvs analogous to transthoracic echocardiography (tte) and that rvs on ct is associated with adverse outcomes after pe. | 2017 | 27664798 |
| identification of key genes involved in polysaccharide bioflocculant synthesis in bacillus licheniformis. | the present study reports the sequenced genome of bacillus licheniformis cgmcc 2876, which is composed of a 4,284,461 bp chromosome that contains 4,188 protein-coding genes, 72 trna genes, and 21 rrna genes. additional analysis revealed an eps gene cluster with 16 open reading frames. conserved domains database analysis combined with qpcr experiments indicated that all genes in this cluster were involved in polysaccharide bioflocculant synthesis. phosphoglucomutase and udp-glucose pyrophosphoryl ... | 2017 | 27667128 |
| synergistic effect of photosynthetic bacteria and isolated bacteria in their antifungal activities against root rot fungi. | antifungal bacteria (ab) in root rot fungus (rrf)-contaminated sweet potato farms were isolated, and seven strains were initially chosen as antagonistic candidates. an antagonistic test by using the mycelial disk placement method revealed that one ab strain by itself could inhibit the rrf growth. this ab strain was identified as bacillus polyfermenticus based on phylogeny of 16s ribosomal rna genes. two ab strains (bacillus aerophilus) displayed high levels of antifungal activity when paired wit ... | 2016 | 27667522 |
| activation of the glutamic acid-dependent acid resistance system in escherichia coli bl21(de3) leads to increase of the fatty acid biotransformation activity. | the biosynthesis of carboxylic acids including fatty acids from biomass is central in envisaged biorefinery concepts. the productivities are often, however, low due to product toxicity that hamper whole-cell biocatalyst performance. here, we have investigated factors that influence the tolerance of escherichia coli to medium chain carboxylic acid (i.e., n-heptanoic acid)-induced stress. the metabolic and genomic responses of e. coli bl21(de3) and mg1655 grown in the presence of n-heptanoic acid ... | 2016 | 27681369 |
| tapse: an old but useful tool in different diseases. | rv function is an important component of overall heart function with prognostic value in predicting symptomatic limitation and outcome in different cardiovascular pathologies. rv longitudinal contraction accounts for the majority of total rv function, up to 80%, as compared to transverse shortening. calculation of rv volume and rv ejection fraction (rvef) remains hampered by the complex rv geometry and we lack a good geometric model allowing the calculation of right ventricular ejection fraction ... | 2016 | 27728861 |
| metabolic engineering of escherichia coli for astragalin biosynthesis. | astragalin (kaempferol 3-o-glucoside) is used as a standard to assess the quality of radix astragali and has exhibited a number of biological properties. in this work, we screened several udp-dependent glycosyltransferases (ugt) for their potential as efficient biocatalysts for astragalin synthesis. the highest astragalin production with 285 mg/l was detected in the recombinant strain expressing ugt from arabidopis thaliana (atugt78d2). to further improve astragalin production, an efficient udp- ... | 2016 | 27730814 |
| myocardial strain pattern in patients with cardiac amyloidosis secondary to multiple myeloma: a cardiac mri feature tracking study. | cardiac mri is frequently used in the diagnosis of cardiac amyloidosis. feature tracking is a novel method of analyzing myocardial strain at the myocardial borders. we investigated myocardial deformation mechanics of both the right and left ventricles in patients with multiple myeloma with suspected cardiac amyloidosis. comprehensive strain analysis was performed in 43 patients with multiple myeloma and suspected cardiac amyloidosis. mri strain by feature tracking was measured using 2d cardiac p ... | 2018 | 27743139 |
| homo-succinic acid production by metabolically engineered mannheimia succiniciproducens. | succinic acid (sa) is a four carbon dicarboxylic acid of great industrial interest that can be produced by microbial fermentation. here we report development of a high-yield homo-sa producing mannheimia succiniciproducens strain by metabolic engineering. the palfk strain (ldha-, pta-, acka-, frua-) was developed based on optimization of carbon flux towards sa production while minimizing byproducts formation through the integrated application of in silico genome-scale metabolic flux analysis, omi ... | 2016 | 27746096 |
| prospective risk analysis of hepatocellular carcinoma in patients with chronic hepatitis c by ultrasound strain elastography. | we have reported about real-time tissue elastography (rte), which displays relative strain by measuring the relative distortion of the tissue, and found this information to be useful for diagnosing liver fibrosis. however, its use in predicting hepatocellular carcinoma has not been reported as yet. here, we investigated rte to predict liver carcinogenesis in patients with chronic hepatitis c virus (hcv) infection. | 2017 | 27750232 |
| the effect of preparation conditions on raman and photoluminescence of monolayer ws2. | we report on preparation dependent properties observed in monolayer ws2 samples synthesized via chemical vapor deposition (cvd) on a variety of common substrates (si/sio2, sapphire, fused silica) as well as samples that were transferred from the growth substrate onto a new substrate. the as-grown cvd materials (as-ws2) exhibit distinctly different optical properties than transferred ws2 (x-ws2). in the case of cvd growth on si/sio2, following transfer to fresh si/sio2 there is a ~50 mev shift of ... | 2016 | 27752042 |
| a novel library-independent approach based on high-throughput cultivation in bioscreen and fingerprinting by ftir spectroscopy for microbial source tracking in food industry. | microbiological source tracking (mst) for food industry is a rapid growing area of research and technology development. in this paper, a new library-independent approach for mst is presented. it is based on a high-throughput liquid microcultivation and ftir spectroscopy. in this approach, ftir spectra obtained from micro-organisms isolated along the production line and a product are compared to each other. we tested and evaluated the new source tracking approach by simulating a source tracking s ... | 2017 | 27783405 |
| sustaining interferon induction by a high-passage atypical porcine reproductive and respiratory syndrome virus strain. | porcine reproductive and respiratory syndrome virus (prrsv) strain a2mc2 induces type i interferons in cultured cells. the objective of this study was to attenuate this strain by serial passaging in marc-145 cells and assess its virulence and immunogenicity in pigs. the a2mc2 serially passaged 90 times (a2mc2-p90) retains the feature of interferon induction. the a2mc2-p90 replicates faster with a higher virus yield than wild type a2mc2 virus. infection of primary pulmonary alveolar macrophages ( ... | 2016 | 27805024 |
| left atrial dysfunction in the pathogenesis of cryptogenic stroke: novel insights from speckle-tracking echocardiography. | myocardial strain analysis by speckle-tracking echocardiography, which can detect subtle abnormalities in left atrial (la) function, may offer unique insights into la pathophysiology in patients with cryptogenic stroke (cs). the aim of this study was to investigate whether la reservoir strain by speckle-tracking echocardiography, as a measure of la compliance, is impaired in patients with cs and no history of atrial fibrillation. | 2017 | 27843104 |
| [population monitoring of the health shaping environment of the students of nagorno karabakh]. | the study of the health shaping environment of students is one of the actual biomedical tasks, it is also the scientific founding for conducting health-preventive and health-preserving measures. despite the importance of the proposed problem, this study is a pioneering attempt in nagorno karabakh. the objective of the work is the scientific grounding of regional peculiarities and the contemporary level of health shaping environment of students on the basis of population monitoring system. the re ... | 2016 | 27845291 |
| origins of the current seventh cholera pandemic. | vibrio cholerae has caused seven cholera pandemics since 1817, imposing terror on much of the world, but bacterial strains are currently only available for the sixth and seventh pandemics. the el tor biotype seventh pandemic began in 1961 in indonesia, but did not originate directly from the classical biotype sixth-pandemic strain. previous studies focused mainly on the spread of the seventh pandemic after 1970. here, we analyze in unprecedented detail the origin, evolution, and transition to pa ... | 2016 | 27849586 |
| echocardiographic comparison between left ventricular non-compaction and hypertrophic cardiomyopathy. | modern imaging technology has improved detection of left ventricular non-compaction cardiomyopathy (lvnc). hypertrophic cardiomyopathy (hcm) shares morphological features with lvnc, but prognosis and treatment strategies differ between lvnc and hcm. | 2017 | 27894062 |
| lamina cribrosa in glaucoma. | this article presents, summarizes, and interprets the most recent advances in the study and understanding of the lamina cribrosa in glaucoma, in the context of previous work. | 2017 | 27898470 |
| serum levels of n-terminal-pro b-type natriuretic peptide as a diagnostic marker for left ventricular dysfunction in children with end-stage renal disease on hemodialysis. | the objective of this study was to determine the diagnostic cutoff value of n-terminal-pro b-type natriuretic peptide (nt-pro bnp) as a marker of left ventricular (lv) dysfunction in children with end-stage renal disease (esrd) on regular hemodialysis (hd). the study was carried out on thirty children with esrd on regular hd and thirty healthy controls. echocardiographic studies were done, including a conventional mode for ejection fraction, fractional shortening, tissue doppler imaging, and lon ... | 2017 | 27900955 |
| high spatial resolution distributed fiber system for multi-parameter sensing based on modulated pulses. | we demonstrate a cost-effective distributed fiber sensing system for the multi-parameter detection of the vibration, the temperature, and the strain by integrating phase-sensitive optical time domain reflectometry (φ-otdr) and brillouin optical time domain reflectometry (b-otdr). taking advantage of the fast changing property of the vibration and the static properties of the temperature and the strain, both the width and intensity of the laser pulses are modulated and injected into the single-mo ... | 2016 | 27906320 |
| ip3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes. | lithium is the prototype mood stabilizer but its mechanism is still unresolved. two hypotheses dominate-the consequences of lithium's inhibition of inositol monophosphatase at therapeutically relevant concentrations (the 'inositol depletion' hypothesis), and of glycogen-synthase kinase-3. to further elaborate the inositol depletion hypothesis that did not decisively determine whether inositol depletion per se, or phosphoinositols accumulation induces the beneficial effects, we utilized knockout ... | 2016 | 27922641 |
| facilitation of dna self-assembly by relieving the torsional strains between building blocks. | paranemic crossover (px) dna motifs were designed and used for self-assembly of two dimensional lattices. the px motifs tested include overwound and underwound ones, and different forms of self-assembled two-dimensional (2d) lattices were generated, demonstrating the correlation between the helical torsional strain within the system and the quality of the lattice formed. relief of the torsional strain by adjusting the number of base pairs in the jx region adjacent to the px motifs, facilitates a ... | 2017 | 27924995 |
| influence of chronic heat acclimatization on occupational thermal strain in tropical field conditions. | to examine whether non-heat acclimatized (nha) emergency responders endure greater physiological and perceptual strain than heat acclimatized (ha) counterparts in tropical field settings. | 2016 | 27930487 |
| improvement of system capacitance via weavable superelastic biscrolled yarn supercapacitors. | yarn-based supercapacitors having improved performance are needed for existing and emerging wearable applications. here, we report weavable carbon nanotube yarn supercapacitors having high performance because of high loadings of rapidly accessible charge storage particles (above 90 wt% mno2). the yarn electrodes are made by a biscrolling process that traps host mno2 nanoparticles within the galleries of helically scrolled carbon nanotube sheets, which provide strength and electrical conductivity ... | 2016 | 27976668 |
| highly stretchable and highly conductive pedot:pss/ionic liquid composite transparent electrodes for solution-processed stretchable electronics. | stretchable conductive materials have received great attention owing to their potential for realizing next-generation stretchable electronics. however, the simultaneous achievement of excellent mechanical stretchability and high electrical conductivity as well as cost-effective fabrication has been a significant challenge. here, we report a highly stretchable and highly conducting polymer that was obtained by incorporating an ionic liquid. when 1-ethyl-3-methylimidazolium tetracyanoborate (emim ... | 2017 | 27990796 |
| speckle tracking and transthyretin amyloid cardiomyopathy. | amyloidosis is a disease caused by deposits of insoluble fibrils in extracellular spaces. the most common type of familial amyloidosis is mediated by mutation of transthyretin, especially val30met. symptoms and ejection fraction decrease may occur in cardiac amyloidosis only in case of poor prognosis. myocardial strain detected by two-dimensional speckle tracking echocardiography can indicate changes in myocardial function at early stages of the disease. | 2017 | 27992035 |
| molecular analysis of pfs47-mediated plasmodium evasion of mosquito immunity. | malaria is a life-threatening disease caused by plasmodium falciparum parasites that is transmitted through the bites of infected anopheline mosquitoes. p. falciparum dispersal from africa, as a result of human migration, required adaptation of the parasite to several different indigenous anopheline species. the mosquito immune system can greatly limit infection and p. falciparum evolved a strategy to evade these responses that is mediated by the pfs47 gene. pfs47 is a polymorphic gene with sign ... | 2016 | 27992481 |
| identification of group g streptococci isolates from companion animals in japan and their antimicrobial resistance. | this study determined species-level identification and antimicrobial resistance (amr) properties in group g streptococci (ggs) isolates from companion animals in japan. strains were isolated from sterile/non-sterile specimens of 72 animals with clinical symptoms or signs in april-may, 2015. we identified them based on 16s rrna sequencing, mass spectrometry (ms), and an automated method based on their biochemical properties. antimicrobial susceptibility was determined with broth microdilution met ... | 2016 | 28003600 |
| impact of surgical pulmonary valve replacement on ventricular mechanics in children with repaired tetralogy of fallot. | impaired ventricular myocardial mechanics are observed in patients with repaired tetralogy of fallot (rtof). effects of pulmonary valve replacement (pvr) on ventricular remodeling are controversial. the objective was to assess the impact of surgical pvr on ventricular mechanics in pediatric patients after rtof. speckle-tracking analysis was performed in 50 rtof children, aged 12.6 ± 3.3 years, pre-operatively and 14.5 ± 2.2 months post-pvr. early post-operative studies 2.2 ± 0.6 months post-pvr ... | 2017 | 28005218 |
| pyruvate dehydrogenase complex regulator (pdhr) gene deletion boosts glucose metabolism in escherichia coli under oxygen-limited culture conditions. | pyruvate dehydrogenase complex regulator (pdhr) is a transcriptional regulator that negatively regulates formation of pyruvate dehydrogenase complex (pdhc), nadh dehydrogenase (ndh)-2, and cytochrome bo3 oxidase in escherichia coli. to investigate the effects of a pdhr defect on glucose metabolism, a pdhr deletion mutant was derived from the wild-type e. coli w1485 strain by λ red-mediated recombination. while no difference in the fermentation profiles was observed between the two strains under ... | 2017 | 28007420 |
| the virulence of streptococcus pneumoniae partially depends on dpra. | streptococcus pneumoniae is one of the most frequent opportunistic pathogens worldwide. dna processing protein a (dpra) is an important factor involved in bacterial uptake and dna integration into bacterial genome, but its role in s. pneumoniae virulence remains unclear. the aim of this study was to characterize the effects of the pneumococcal dpra gene on the pathogenesis of s. pneumoniae. to construct a dpra-deficient pneumococcal strain, the dpra gene of the s. pneumoniae strain d39 was inact ... | 2017 | 28011228 |
| the utility of a country-specific bartonella henselae antigen in an igm-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease. | bartonella henselae strains genetically differ among nations. the utility of japanese-specific yh-01 strain was investigated in developing indirect fluorescence antibody assay (ifa) for igm in comparison with conventional ifa employing houston-1 strain by testing 100 japanese patients suspected of cat scratch disease. the country-specific ifa greatly improved the accuracy of diagnosis. | 2017 | 28029424 |
| two-dimensional right ventricular strain by speckle tracking for assessment of longitudinal right ventricular function after paediatric congenital heart disease surgery. | right ventricular (rv) function is a prognostic marker of cardiac disease in children. speckle tracking has been developed to assess rv longitudinal shortening, the dominant deformation during systole; little is known about its feasibility in children with congenital heart disease (chd). | 2017 | 28034627 |
| modulation of carotid strain by statin therapy in atherosclerosis patients. | the beneficial effect of statin therapy on the progress of atherosclerotic disease has been demonstrated by numerous studies. vascular strain imaging is an arising method to evaluate arterial stiffness. our study examined whether an influence of statin therapy on the vessel wall could be detected by vascular strain imaging. | 2017 | 28043217 |
| aortic atherosclerosis determines increased retrograde blood flow as a potential mechanism of retrograde embolic stroke. | retrograde brain embolization from complex plaques of the proximal descending aorta (dao) has been identified as a new potential mechanism of stroke. our purpose was to identify predictors of increased retrograde aortic blood flow indicating an elevated risk of brain embolization from the dao. | 2017 | 28049202 |
| comparison of global myocardial strain assessed by cardiovascular magnetic resonance tagging and feature tracking to infarct size at predicting remodelling following stemi. | to determine if global strain parameters measured by cardiovascular magnetic resonance (cmr) acutely following st-segment elevation myocardial infarction (stemi) predict adverse left ventricular (lv) remodelling independent of infarct size (is). | 2017 | 28056808 |
| soluble st2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy. | diagnostic and prognostic evaluation remains challenging in arrhythmogenic right ventricular cardiomyopathy (arvc). we measured plasma concentration of soluble st2 (sst2) and assessed its association with right ventricular (rv) function and ventricular arrhythmias in patients with arvc. | 2017 | 28067540 |
| a prospective survey of pseudomonas aeruginosa colonization and infection in the intensive care unit. | pseudomonas aeruginosa (pa) surveillance may improve empiric antimicrobial therapy, since colonizing strains frequently cause infections. this colonization may be 'endogenous' or 'exogenous', and the source determines infection control measures. we prospectively investigated the sources of pa, the clinical impact of pa colonization upon admission and the dynamics of colonization at different body sites throughout the intensive care unit stay. | 2017 | 28096975 |
| white matter changes in microstructure associated with a maladaptive response to stress in rats. | in today's society, every individual is subjected to stressful stimuli with different intensities and duration. this exposure can be a key trigger in several mental illnesses greatly affecting one's quality of life. yet not all subjects respond equally to the same stimulus and some are able to better adapt to them delaying the onset of its negative consequences. the neural specificities of this adaptation can be essential to understand the true dynamics of stress as well as to design new approac ... | 2017 | 28117841 |
| impact of type i interferon on the safety and immunogenicity of an experimental live-attenuated herpes simplex virus 1 vaccine in mice. | viral fitness dictates virulence and capacity to evade host immune defenses. understanding the biological underpinnings of such features is essential for rational vaccine development. we have previously shown that the live-attenuated herpes simplex virus 1 (hsv-1) mutant lacking the nuclear localization signal (nls) on the icp0 gene (0δnls) is sensitive to inhibition by interferon beta (ifn-β) in vitro and functions as a highly efficacious experimental vaccine. here, we characterize the host imm ... | 2017 | 28122977 |
| global transcriptional responses to osmotic, oxidative, and imipenem stress conditions in pseudomonas putida. | bacteria cope with and adapt to stress by modulating gene expression in response to specific environmental cues. in this study, the transcriptional response of pseudomonas putida kt2440 to osmotic, oxidative, and imipenem stress conditions at two time points was investigated via identification of differentially expressed mrnas and small rnas (srnas). a total of 440 srna transcripts were detected, of which 10% correspond to previously annotated srnas, 40% to novel intergenic transcripts, and 50% ... | 2017 | 28130298 |
| dynamic control of erg20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in saccharomyces cerevisiae. | microbial production of monoterpenes provides a promising substitute for traditional chemical-based methods, but their production is lagging compared with sesquiterpenes. geraniol, a valuable monoterpene alcohol, is widely used in cosmetic, perfume, pharmaceutical and it is also a potential gasoline alternative. previously, we constructed a geraniol production strain by engineering the mevalonate pathway together with the expression of a high-activity geraniol synthase. | 2017 | 28137282 |
| epidemiological investigation of candida species causing bloodstream infection in paediatric small bowel transplant recipients. | small bowel transplantation (sbt) can be a life-saving medical procedure. however, these recipients experience high risk of bloodstream infections caused by candida. this research aims to characterise the sbt recipient gut microbiota over time following transplantation and investigate the epidemiology of candidaemia in seven paediatric patients. candida species from the recipients' ileum and bloodstream were identified by internal transcribed spacer sequence and distinguished to strain by multil ... | 2017 | 28139856 |
| a p-coumaroyl esterase from rhizoctonia solani with a pronounced chlorogenic acid esterase activity. | extracellular esterase activity was detected in submerged cultures of rhizoctonia solani grown in the presence of sugar beet pectin or tween 80. putative type b feruloyl esterase (fae) coding sequences found in the genome data of the basidiomycete were heterologously expressed in pichia pastoris. recombinant enzyme production on the 5-l bioreactor scale (rs pcae: 3245ul(-1)) exceeded the productivity of the wild type strain by a factor of 800. based on substrate specificity profiling, the purifi ... | 2017 | 28159727 |
| genetic identification of cattle hydatid cyst isolates from northeast and southwest of iran | cystic echinococcosis (ce) caused by the larval stages of taeniid cestodes of the genus echinococcus is a neglected helminth zoonosis affecting humans and various animal species. the aim of this study was to assess the fertility of cattle from two provinces in the northeast and southwest of iran, and molecularly characterize the hydatid cysts collected from them. from 5000 carcasses of naturally infected cattle inspected from october 2013 to december 2015, 70 hydatid cysts were collected in mash ... | 2016 | 28160770 |
| saccharopolyspora species: laboratory maintenance and enhanced production of secondary metabolites. | saccharopolyspora spp. are aerobic, gram-positive, non-acid-fast, and non-motile actinomycetes. various species of the genus saccharopolyspora have been reported with an ability to produce various bioactive compounds for pharmaceutical and agricultural uses. this unit includes general protocols for the laboratory maintenance of saccharopolyspora species, including growth in liquid medium, growth on solid agar, long-term storage, and generation of a higher producer strain by mutagenesis. saccharo ... | 2017 | 28166382 |
| actinomadura species: laboratory maintenance and ribosome engineering. | actinomadura spp. are aerobic, gram-positive, catalase-positive, non-acid fast, non-motile actinomycetes. some species of actinomadura are associated with opportunistic infections in humans. however, many bioactive compounds with pharmaceutical applications can be isolated from various actinomadura spp. this unit includes general protocols for the laboratory maintenance of actinomadura spp., including growth in liquid medium, growth on solid agar, long-term storage, and generation of a higher pr ... | 2017 | 28166386 |
| circumferential strain by velocity vector imaging and speckle-tracking echocardiography: validation against sonomicrometry in an aortic phantom. | evaluation of arterial deformation and mechanics using strain analysis on ultrasound greyscale images has gained increasing scientific interest. the aim of this study was to validate in vitro measurements of circumferential strain by velocity vector imaging (vvi) and speckle-tracking echocardiography (ste) against sonomicrometry as a reference method. | 2018 | 28168822 |
| identification of a candidate standard strain of severe fever with thrombocytopenia syndrome virus for vaccine quality control in china using a cross-neutralization assay. | severe fever with thrombocytopenia syndrome (sfts) is caused by a phlebovirus of the bunyaviridae family, which is designated as sfts virus (sftsv). to our knowledge, no efficient sftsv vaccine exists. here, we report the identification of a standard virus strain for the eight major sftsv strains circulating in china for use in evaluating the sftsv vaccine. rabbits were immunized with the sftsv strains and the cross-neutralization capacities of sftsv anti-sera were determined in microculture cyt ... | 2017 | 28173977 |
| immunogenicity of amino acids 1-150 of streptococcus gapc displayed on the surface of escherichia coli. | streptococcus is one of the main pathogens that cause bovine mastitis. they includes into s.agalactiae, s.dysgalactiae, and s.uberis. the gapc protein is a virulence factor that is expressed on the surface of streptococcus species. gapc is highly antigenic and immunization with gapc confers cross-protection against all three species. our previous data showed that amino acids 1-150 of gapc (gapc1-150) of s. dysgalactiae conferred similar immunoprotection compared to full-length gapc. thus, the pr ... | 2017 | 28179116 |
| re-analysis of unassigned hepatitis c virus (hcv) strain cyhcv025: evidence of a highly divergent lineage within genotype 1. | hcv global sequences have been classified into 7 genotypes, several subtypes and a number of unassigned sequences. our aim was to perform an in depth investigation of the taxonomic relationships of the unclassified cyhcv025 strain by means of phylogenetic analysis. phylogenetic tree reconstructions were performed using ml methods on full-length genomic and partial hcv alignments. phylogenetic analysis of full-length sequences revealed that cyhcv025 clustered close to the root node of genotype 1, ... | 2017 | 28179183 |
| changes in left ventricular global and regional longitudinal strain during right ventricular pacing. | our study aimed to demonstrate the short-term impacts of right ventricular apical pacing (rvap) and right ventricular septal pacing (rvsp) on left ventricular (lv) regional longitudinal strain (rls) and global longitudinal strain (gls) in patients with preserved ejection fraction (ef). lv strain and functions may be altered by rvap. rvsp might be a better alternative. the detrimental effect of right ventricular (rv) pacing may be mediated by regional lv impairment. | 2016 | 28197264 |
| a high-temperature passaging attenuated pseudorabies vaccine protects piglets completely against emerging prv variant. | emerging variant of pseudorabies virus (prv) have evaded the antiviral immunity of commercially available prv vaccine and have led to prv outbreaks in chinese pig farms. here, we attenuated a prv variant strain by serial passages in vitro and evaluate the protective efficacy of the attenuated strain as a vaccine candidate. the virulent prv variant strain js-2012 was continuously passaged in vero cells at 40°c and attenuated rapidly. after 90 passages in vero cells, the passaged virus lost its ab ... | 2017 | 28214681 |
| effect of cellular and extracellular pathology assessed by t1 mapping on regional contractile function in hypertrophic cardiomyopathy. | regional contractile dysfunction is a frequent finding in hypertrophic cardiomyopathy (hcm). we aimed to investigate the contribution of different tissue characteristics in hcm to regional contractile dysfunction. | 2017 | 28215181 |
| integration of highly strained sige in source and drain with hk and mg for 22 nm bulk pmos transistors. | in this study, the integration of sige selective epitaxy on source/drain regions and high-k and metal gate for 22 nm node bulk pmos transistors has been presented. selective si1-x ge x growth (0.35 ≤ × ≤ 0.40) with boron concentration of 1-3 × 1020 cm-3 was used to elevate the source/drain. the main focus was optimization of the growth parameters to improve the epitaxial quality where the high-resolution x-ray diffraction (hrxrd) and energy dispersive spectrometer (eds) measurement data provided ... | 2017 | 28228008 |
| single nucleotide polymorphism genotyping of erysipelothrix rhusiopathiae isolates from pigs affected with chronic erysipelas in japan. | over the past decades, erysipelothrix rhusiopathiae strains displaying similar phenotypic and genetic profiles of the attenuated, acriflavine-resistant e. rhusiopathiae koganei 65-0.15 strain (serovar 1a) have been frequently isolated from pigs affected with chronic erysipelas in japan. in this study, using the conventional pcr assay that was designed to detect strain-specific single nucleotide polymorphism (snp) sites found in the genome of the vaccine strain, we analyzed e. rhusiopathiae isola ... | 2017 | 28250289 |
| salmonella senftenberg adaptation to linalool and its association with antibiotic resistance and environmental persistence. | a clinical isolate of salmonella enterica serovar senftenberg, isolated from an outbreak linked to the herb ocimum basilicum l. (basil), has been shown resistance to basil oil and to the terpene alcohol linalool. to better understand how human pathogens might develop resistance to linalool and to investigate the association of this resistance with resistance to different antimicrobial agents, selective pressure was applied to the wild-type strain by sequential exposure to increasing concentratio ... | 2017 | 28258149 |
| global longitudinal strain by echocardiography predicts long-term risk of cardiovascular morbidity and mortality in a low-risk general population: the copenhagen city heart study. | global longitudinal strain (gls) is prognostic of adverse cardiovascular outcomes in various patient populations, but the prognostic utility of gls for long-term cardiovascular morbidity and mortality in the general population is unknown. | 2017 | 28264868 |
| design of a synthetic yeast genome. | we describe complete design of a synthetic eukaryotic genome, sc2.0, a highly modified saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or altered. sc2.0 chromosome design was implemented with biostudio, an open-source framework developed for eukaryotic genome design, which coordinates design modifications from nucleotide to genome scales and enforces version control to systematically track edits. to achieve complete sc2. ... | 2017 | 28280199 |
| a multisensing setup for the intelligent tire monitoring. | the present paper offers the chance to experimentally measure, for the first time, the internal tire strain by optical fiber sensors during the tire rolling in real operating conditions. the phenomena that take place during the tire rolling are in fact far from being completely understood. despite several models available in the technical literature, there is not a correspondently large set of experimental observations. the paper includes the detailed description of the new multi-sensing technol ... | 2017 | 28287503 |
| murine cytomegalovirus infection induces susceptibility to eae in resistant balb/c mice. | in contrast to c57bl/6 mice, balb/c mice are relatively resistant to the induction of experimental autoimmune encephalomyelitis (eae) after challenge with mog35-55 peptide. here, we provide the first evidence that infection with murine cytomegalovirus (mcmv) in adulthood abrogates this resistance. infected balb/c mice developed clinical and histological signs similar to those seen in susceptible c57bl/6 mice. in addition to cd4(+) cells, large proportion of cells in the infiltrate of diseased ba ... | 2017 | 28289417 |
| combinatorial analysis of enzymatic bottlenecks of l-tyrosine pathway by p-coumaric acid production in saccharomyces cerevisiae. | to identify new enzymatic bottlenecks of l-tyrosine pathway for further improving the production of l-tyrosine and its derivatives. | 2017 | 28299546 |
| polarity control of h-bn nanoribbon edges by strain and edge termination. | we studied the polarity of h-bn nano-flakes in terms of their edge geometries, edge hydrogen termination, and uniaxial strain by evaluating their electrostatic potential using density functional theory. our calculations have shown that the polarity of the nanoribbons is sensitive to their edge shape, edge termination, and uniaxial tensile strain. polarity inversion of the ribbons can be induced by controlling the hydrogen concentration at the edges and the uniaxial tensile strain. the polarity i ... | 2017 | 28317994 |
| profiles of long noncoding rnas in hypertensive rats: long noncoding rna xr007793 regulates cyclic strain-induced proliferation and migration of vascular smooth muscle cells. | long noncoding rnas (lncrnas) are being discovered in multiple diseases at a rapid pace. however, the contribution of lncrnas to hypertension remains largely unknown. in hypertension, the vascular walls are exposed to abnormal mechanical cyclic strain, which leads to vascular remodelling. here, we investigated the mechanobiological role of lncrnas in hypertension. | 2017 | 28319593 |
| biofilm inhibition formation of clinical strains of pseudomonas aeruginosa mutans, photocatalytic activity of azo dye and gc-ms analysis of leaves of lagerstroemia speciosa. | the investigation was conducted to analyse the bioactive compounds from the leaf extracts of l. speciosa by gc-ms. the extracts were screened for antibacterial and antibiofilm activities against potential clinical strains. the bioactive compounds from the leaves of l. speciosa were extracted by soxhlet continuous extraction method and their chemical composition was analysed by gas chromatography-mass spectroscopy (gc-ms). the antibacterial activity was evaluated against clinical strain like stap ... | 2017 | 28319869 |
| distribution and persistence of sterile screwworms (diptera: calliphoridae) released at the panama-colombia border. | the sterile insect technique is used by the comisión panamá - estados unidos para la erradicación y prevención del gusano barrenador del ganado (copeg) to maintain a barrier at the border of panama and colombia to prevent screwworms, cochliomyia hominivorax (coquerel), from south america reinfesting north america. before studying the distribution and persistence of sterilized, mass-produced screwworms released in the barrier zone, the utility of applying fluorescent dust (∼1.0 mg/fly) to pupae a ... | 2017 | 28334298 |
| comparison of displacement encoding with stimulated echoes to magnetic resonance feature tracking for the assessment of myocardial strain in patients with acute myocardial infarction. | the aim of this study was to compare myocardial strain by cardiovascular magnetic resonance feature tracking (cmr-ft) to those derived from displacement encoding with stimulated echoes (dense) in patients with acute myocardial infarction (ami). twenty patients (65 pa13 years) with ami underwent cine, dense, black-blood t2-weighted and late gadolinium enhancement cmr at 1.5 t. global and segmental strain was determined by cmr-ft analysis and dense on matched 3 short-axis planes. global circumfere ... | 2017 | 28335982 |
| characterization of a hypervirulent fowl adenovirus 4 with the novel genotype newly prevalent in china and establishment of reproduction infection model of hydropericardium syndrome in chickens. | severe hydropericardium syndrome (hps) has been present in layers in the northeast of china since june 2015, with mortality rates varying from 30 to 90%. dead layers had severe hydropericardium with pericardial volumes of 5 to 20 ml, as well as inclusion body hepatitis. laboratory investigations led to the isolation of a fowl adenovirus strain, hljfad15, from the liver tissue of dead layers. natural deletions of orf19 and orf27 were found in this clinical strain by complete genome sequencing, wh ... | 2017 | 28339951 |
| normal ranges of left atrial strain by speckle-tracking echocardiography: a systematic review and meta-analysis. | recent advances in the assessment of myocardial function have facilitated the direct measurement of atrial function using speckle-tracking echocardiography. currently, normal reference ranges for atrial function using speckle-tracking echocardiography are based on a few initial studies, with variations among modestly sized (n = 100-350) studies. | 2017 | 28341032 |
| identification of a polysaccharide produced by the pyruvate overproducer candida glabrata cctcc m202019. | candida glabrata has great potential for the accumulation of pyruvate as a preferred strain in pyruvate production by fermentation. however, its substrate conversion rate is relatively low. in this study, a novel polysaccharide containing α-1,4-glucosidic bonds was observed accidentally in screening a high-titer pyruvate strain by atmospheric and room temperature plasma mutagenesis of c. glabrata. chemical analysis of the partially purified polysaccharide s4-c10 showed the main components were 1 ... | 2017 | 28343242 |
| selenium-mediated protection in reversing the sensitivity of bacterium to the bactericidal antibiotics. | inducing production of damaging reactive oxygen species (ros) is an important criterion to distinguish the bactericidal antibiotics from bacteriostatic antibiotics. selenoenzymes were generally recognized to be a powerful antioxidant capable of scavenging free radicals, protecting the cells from the harmful effects of ros. therefore, the present study was carried out to investigate the selenium (se)-mediated protection in reversing antibiotic sensitivity and the role of selenoenzymes in alleviat ... | 2017 | 28347459 |
| directly embroidered microtubes for fluid transport in wearable applications. | we demonstrate, for the first time, a facile and low-cost approach for integrating highly flexible and stretchable microfluidic channels into textile-based substrates. the integration of the microfluidics is accomplished by means of directly embroidering surface-functionalized micro-tubing in a zigzag/meander pattern and subsequently coating it with an elastomer for irreversible bonding. we show the utility of the embroidered micro-tubing by developing robust and stretchable drug-delivery and el ... | 2017 | 28379278 |
| role of the srrz/rz1 lambdoid lysis cassette in the pathoadaptive evolution of shigella. | shigella, the etiological agent of bacillary dysentery (shigellosis), is a highly adapted human pathogen. it evolved from an innocuous ancestor resembling the escherichia coli strain by gain and loss of genes and functions. while the gain process concerns the acquisition of the genetic determinants of virulence, the loss is related to the adaptation of the genome to the new pathogenic status and occurs by pathoadaptive mutation of antivirulence genes. in this study, we highlight that the srrz/rz ... | 2017 | 28389211 |