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treatment of microsporum spp. tinea capitis with pulsed oral terbinafine.oral terbinafine is widely used in the treatment of superficial dermatomycoses as well as subcutaneous and systemic mycoses. it is also useful in treating tinea capitis, although for microsporum canis and some ectothrix organisms, the effectiveness of the drug may be less than for some endothrix infections. in this study, we undertook a double-blind randomized trial comparing standard and double doses of terbinafine given in a pulsed protocol (1 week on, 3 weeks off) in treating microsporum spp. ...200415115516
[chitin synthase (chs) gene analysis of dermatophytes].about 620-bp genomic dna fragments of chs1 genes were amplified from 13 species of dermatophytes by polymerase chain reaction (pcr) and sequenced. the phylogenetic analysis of chs1 gene fragments of these dermatophyte species revealed that 3 genera of epidermophyton, microsporum and trichophyton were genetically different from each other. the molecular analysis of chs1 genes will provide useful information for the identification of dermatophytes. the species-specific primers were designed from t ...200415118658
study of the dermatophytes in dogs and the risk of human infection.the infiltrative growth of fungi that multiplies in the tissues (dermatophytes, candida, agents of visceral mycoses) is the generally known proof of "active" functioning of these organisms. the relative importance of fungi as inducers of human and animal diseases grows constantly.200315168865
isolation of dermatophytes and other keratinophilic fungi from the vicinity of salt pan soils of mumbai, india.soil samples from twenty salt pans and their vicinity around mumbai and thane were screened for the occurrence of keratinophilic fungi and related dermatophytes. ten species classified in six genera were recovered using horse hair as bait. the isolated species were reported in the following order of dominance: chrysosporium indicum (12.0%), microsporum gypseum complex (7.2%), c. tropicum (5.6%), c. state of ctenomyces serratus (4.0%), trichophyton terrestre (3.2%), malbranchea aurantiaca (2.4%), ...200415180153
etiology of tinea capitis in athens, greece -- a 6-year (1996-2001) retrospective study.a total of 577 patients with tinea capitis have been diagnosed at the mycology laboratory of 'a. sygros' hospital of skin and venereal diseases, athens, greece between 1996 and 2001. from these patients, 100 were immigrants from balkan, near east and african countries. the vast majority of the patients (95%) were children, mainly at preschool and school age and only 5% were adults. zoophilic dermatophytes accounted for 86.5% followed by anthropophilic (12.4%) and geophilic (1.2%) dermatophytes. ...200415189185
keratinophilic fungi on feathers of pigeon in maharashtra, india.results of a preliminary survey of keratinophilic fungi associated with feathers of pigeon on high rise buildings in thane district of maharashtra (india) are reported. a total of 100 samples were examined, of which 67 samples were positive for keratinophilic fungi. altogether 67 fungal strains belonging to 10 species of seven genera were isolated viz. chrysosporium indicum (24%), chrysosporium sp. (2%), chr. tropicum (8%), chrysosporium state of arthroderma tuberculatum (3%), chrysosporium stat ...200415189186
the epidemiology of microsporum canis infections in rijeka area, croatia.the aim of the study was to analyze the microsporum canis infections in the rijeka area, croatia, observed between 1990 and 2001. a total of 724 cases of dermatophytosis caused by m. canis were diagnosed in 320 individuals with the tinea capitis and 404 with tinea corporis. the m. canis infections constituted 32.8% of all dermatophytes isolated during the study period.200415189188
kerion celsi in a newborn due to microsporum canis.the present study deals with a case of a 40-day-old girl with kerion celsi caused by microsporum canis. the source of the infection were the parents who presented tinea corporis caused by m. canis. systemic treatment was carried out with terbinafine and complete recovery was achieved. tinea capitis is unusual in children during their first year of life and its evolution towards kerion is very rare in newborns.200415189191
disseminated dermatophytosis caused by microsporum gypseum in an aids patient: response to terbinafine and amorolfine.a 51-year-old white male, native of rio de janeiro, brazil, with advanced aids and in chronic use of imidazoles for oral candidosis, presented erythematous, desquamative, pruriginous plaques of 1 month evolution on the trunk, inguinal/crural region, and lower limbs. the diagnosis of dermatophytosis was based on the isolation of microsporum gypseum from scales scraped from the skin lesions. the lesions regressed after 30 days treatment with itraconazole, 100 mg day(-1). after interruption of this ...200415189192
antifungal cobalt(ii), copper(ii), nickel(ii) and zinc(ii) complexes of furanyl-,thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins.some novel cephalexin-derived furanyl, thiophenyl, pyrrolyl, salicylyl and pyridyl schiff's bases and their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes have been synthesized and studied for their antifungal properties against trichophyton longifusus, candida albicans, aspergillus flavus, microsporum canis, fusarium solani and candida glaberata. the presence of metal ions in the investigated schiff's base complexes reported here lead to significant antifungal activity, whereas t ...200415202498
development of an in vitro, isolated, infected spore testing model for disinfectant testing of microsporum canis isolates.the isolated infected hair model is a commonly used technique to test the fungicidal efficacy of topical therapies against microsporum canis. the most commonly used model uses mats of infective hairs, and results from various laboratories have differed. the objectives of this study were to develop a method to produce spores for testing when only mycelial forms were available and to develop a semiquantitative testing method that used only infective spores from hairs, and not pooled hair samples f ...200415214954
generalized microsporum canis dermatophytosis in six yorkshire terrier dogs.six yorkshire terrier dogs with generalized, chronic dermatophytosis caused by microsporum canis were seen over a 3-year period. specific tests showed that they also had concurrent leishmaniosis (four cases), leishmaniosis and ehrlichiosis (one case) or diabetes mellitus (one case). although specific therapy for these infectious diseases was instituted and the dogs were treated systemically and topically with appropriate antifungal drugs, only partial clinical resolution of the dermatophytosis w ...200415214955
intra- and interlaboratory study of a method for testing the antifungal susceptibilities of dermatophytes.the national committee for clinical laboratory standards (nccls) m38-a standard for the susceptibility testing of conidium-forming filamentous fungi does not explicitly address the testing of dermatophytes. this multicenter study, involving six laboratories, investigated the mic reproducibility of seven antifungal agents tested against 25 dermatophyte isolates (5 blinded pairs of five dermatophyte species per site for a total of 300 tests), using the method of dermatophyte testing developed at t ...200415243047
(e)- and (z)-1,2,4-triazolylchromanone oxime ethers as conformationally constrained antifungals.a series of 1,2,4-triazolylchromanone oxime ethers were synthesized and tested for in vitro antifungal activity. many of these derivatives exhibit high activity against candida albicans, saccharomyces cerevisiae, aspergillus niger and microsporum gypseum.200415246073
frequency and risk factors of dermatophytosis in students living in rural areas in eskişehir, turkey.our study included 2384 students from five villages around eskişehir, turkey. we asked every student for their personal identification and also for their sanitation in order to get an idea about dermatophytosis. samples taken from suspicious lesion were collected and inoculated onto sabouraud dextrose agar slants. for identification of fungi which were grown, macroscopic appearance of colonies, microscopic examination and biochemical tests were used. we found suspicious lesions in 245 (10.3%) an ...200415281399
tinea capitis in kwa-zulu natal, south africa.tinea capitis is the most common dermatophyte infection in children. the hair involvement can be classified as endothrix, ectothrix, or favus, and the clinical appearance is variable. the goal of this study was to determine the demography, etiology, and clinical patterns of tinea capitis in south africa. a prospective, cross-sectional study was conducted over a 1-year period. all cases were classified clinically and subject to wood light examination, microscopy, and culture. one hundred patients ...200415283786
itraconazole in the treatment of tinea capitis caused by microsporum canis: experience in a large cohort.mycotic scalp infection caused by microsporum canis is one of the more recalcitrant disorders, with increasing incidence during the last decade. we report our experience with administration of itraconazole in 163 children (86 girls, 77 boys) with m. canis tinea capitis. fifty-five patients had previous treatment with terbinafine without success. in all children, the dosage of itraconazole was adjusted according to body weight, with 5 mg/kg/day given in a continuous regimen either as a capsule (1 ...200415283801
[statistical study of dermatomycosis for 30 years (1968-1997) in sendai national hospital].a statistical study on dermatomycoses for the 30 years from 1968 to 1997 in the dermatologic section of sendai national hospital was carried out with the following results. the total number of dermatomycosis patients was 14,259 and accounted for 9.59% of all new outpatients during this period. these cases of dermatomycoses were composed of the following: dermatophytoses 10,656, candidiasis 3,287, malassezia infection 566, sporothrichosis 20, aspergillosis 7, and chromomycosis 1. annual changes i ...200415284829
tinea capitis in a dermatology center in the city of fortaleza, brazil: the role of trichophyton tonsurans.over a 3-year period (march 1999 to march 2002), 944 patients with scalp lesions attended a dermatology reference center in the city of fortaleza, ceará, brazil. clinical specimens were examined at the specialized medical mycology center, federal university of ceará, fortaleza-ce, brazil, to detect patients with tinea capitis.200415304180
[update on the diagnosis of dermatomycosis].dermatomycosis are mycotic diseases of skin caused by a few mycetes: dermatophytes, and some opportunistic fungi as malassezia, candida (not c. albicans), trichosporon, rhodutorula, cryptococcus or aspergillus, geotrichum, alternaria, etc. dermatophytes are a group of closely related filamentous fungi that invade keratinized tissue (skin, hair, nails) of humans and other animals and produce infection called dermatophytosis or ringworm or "tinea". the etiological agents of dermatophytosis are cla ...200415305713
dermatophytoses in split and dalmatia, croatia, 1996-2002.the aim of the study was to investigate the epidemiology of dermatophyte infections in split and dalmatia county, croatia, between 1996 and 2002. of 5792 samples 1318 (23.8%) were positive. tinea corporis and tinea cruris were the most common types of dermatophytoses. microsporum canis (36.5%), trichophyton mentagrophytes (24.8%), and t. rubrum (21.5%) were the main etiologic factors.200415310333
dermatophytosis in children and adolescents in gdansk, poland.during a 3-year period (1999-2001) a total of 94 cases of dermatophytosis were seen in patients from 0 to 18 years of age attending the department of dermatology, venerology and allergology of gdańsk medical university. mycoses were diagnosed on the basis of clinical picture and direct microscopy and were confirmed by positive cultures. the most frequent pathogens were microsporum canis (62%) and trichophyton rubrum (12%). the most often forms of dermatophytosis in children were tinea cutis glab ...200415310339
the novel azole r126638 is a selective inhibitor of ergosterol synthesis in candida albicans, trichophyton spp., and microsporum canis.r126638 is a novel triazole with in vitro activity similar to that of itraconazole against dermatophytes, candida spp., and malassezia spp. in animal models of dermatophyte infections, r126638 showed superior antifungal activity. r126638 inhibits ergosterol synthesis in candida albicans, trichophyton mentagrophytes, trichophyton rubrum, and microsporum canis at nanomolar concentrations, with 50% inhibitory concentrations (ic(50)s) similar to those of itraconazole. the decreased synthesis of ergo ...200415328084
[identification of geophilic and zoophilic dermatophytes in siblings with tinea capitis. a pathogenic factor or contamination?].two siblings of african origin presented with multiple scaling patches and alopecia on the scalp four weeks after returning from a vacation in eritrea. direct koh examination revealed fungal elements; trichophyton mentagrophytes and trichophyton terrestre were identified in the fungal culture. we discuss the putative pathogenic role of both microorganisms in causing disease. although infection with microsporum canis currently accounts for almost fifty percent of all cases of tinea capitis in ger ...200415340708
a survey on the pathogenic fungi in soil samples of potted plants from sari hospitals, iran.a total of 23 soil samples of potted plants was collected from hospitals in sari, iran. each sample contained approximately 200 g soil, taken from a depth of 0-10 cm of the pots. samples were analysed by two different methods. (1) culture on sabouraud's dextrose agar medium containing chloramphenicol (sc); cultured fungi were identified by macroscopic and microscopic characterization. (2) the hair-baiting technique (hbt) was used to isolate the keratinophilic fungi. after culture on sc medium, 1 ...200415350715
what is your diagnosis? dermatophytic pseudomycetoma. 200415352405
fuseaux formation of the genus microsporum. 195015404858
microsporum gypsum as an etiologic agent of tinea in the united states. 195015411223
[determatologica; results of different methods of treatment of trichophytosis]. 195015411408
[efficacy sex hormones in the treatment of microsporia]. 195015412006
immunity of the adult scalp to infection with microsporum audouinii. 195015422183
physiological studies on the genus microsporum. 195015422186
endemic of infection with microsporum audouinii in a family of eight persons. 195015426315
effect of yeast extract on microsporum audouini and microsporum canis. 195015433400
large spores (macroconidia, fuseaux) of microsporum audouini in vivo; report of a case. 195015433436
[data on the symptomatology of superficial microsporiasis of the scalp]. 195015434203
[microsporotic focus on lanuginous skin, clinically indifferentiable from trichophytosis]. 195015435113
[microsporotic focus on the scalp]. 195015435114
[epidemiologic and sociohygenic observations on two epidemics of microsporia in cologne]. 195015439940
antibacterial and antifugal mono- and di-substituted symmetrical and unsymmetrical triazine-derived schiff-bases and their transition metal complexes.a new series of antibacterial and antifungal triazine-derived mono- and di-substituted (symmetrical and unsymmetrical) schiff-bases and their cobalt(ii), copper(ii), nickel(ii) and zinc(ii) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments and ir and electronic spectral measurements. ir spectra indicated the ligands to act as tridentate towards divalent metal ions via a trazine-n, the azomethine-n and, indole-nh and deproton ...200415449731
population structure and evolutionary origins of microsporum canis, m. ferrugineum and m. audouinii.the recurrent evolutionary emergence of asexual lineages within sexual zoo- and anthropophilic dermatophyte species living in animal-frequented soil is likely to be triggered by changes in ecological niche, i.e., shifts of host animal. subsequent adaptation to the new host species is noted. sometimes geographic isolation or intrinsic host factors like human race may also play a role in speciation. in the present study, we elaborate concepts of speciation in dermatophytes using the microsporum ca ...200415450196
origins of onychomycosis.onychomycosis, or tinea unguium, is generically thought of as a fungus infection of the nails characterized by thickening, splitting, roughening, and discoloration. this article discusses the origins of this condition as well as methods of classification and evaluation.200415450895
lung cancer epidemiology and risk factors in asia and africa.in industrialised countries, lung cancer is the most common form of cancer among males and it is growing among females. for both sexes, rates reflect smoking behaviours. the pattern appears to be different in asia, particularly in china, where lung cancer rates in men reflect high smoking rates but high rates among non-smoking women appear to be related to other factors. the incidence of lung cancer is low in most african countries, but it is increasing. in addition to tobacco smoking, a number ...200415455588
[dermatophyte infection and colonization in dogs from south santiago, chile].our main aim was to determine the dermatophyte infection and colonization prevalence in canines from south santiago, chile. we studied 241 dogs, 121 of them presented cutaneous lesions suggestive of dermatophytosis and the other 120 were free from lesions and were considered clinically healthy. dermatophytes were isolated from the lesions of 48.8% of animals with cutaneous diseases and from 5% of healthy dogs. microsporum canis was the principal species isolated with a frequency of 98.3% from de ...200315456352
[canine onychomycosis produced by microsporum gypseum. a case report].one case of severe canine onychomycosis is described. the aetiological agent was identified as microsporum gypseum. the incidence of this fungus in this kind of pathology is discussed, with special attention to the successful treatment with topic enilconazole and systemic griseofulvin.200315456357
[superficial infections caused by microsporum canis in humans and animals].dermatophytic infections caused by m. canis in humans and animals have a world wide distribution and they are zoonotic. the objective in this work was to know the frequency of m. canis infections in humans and pets. we studied our cases from january 1994 to december 2002. the human samples were obtained from a dermatological department in a general hospital and we registered the next data: age, sex, job, and affected area. the animal samples were obtained from a mycological veterinary laboratory ...200415458362
[epidemiology of tinea capitis in abidjan, cote d'ivoire].tinea capitis is a dermatosis of the scalp due to dermatophytes that can cause hair loss. it remains a significant endemic problem mainly in school children in tropical regions. the purpose of this case-control study carried out in the dermatology center of treichville hospital was to identify risk factors for tinea capitis in abidjan, cote d'ivoire. a total of 80 cases were recruited on the basis of clinical findings showing one or several plaques showing desquamation or parakeratosis suggestiv ...200415460148
[tinea capitis by microsporum audouinii].we report the case of a four year-old girl from equatorial guinea who had been living in spain for the last month. she presented several alopecic patches on the scalp. the direct study of the hair with 40% koh showed an ectothrix infection and the mycological study revealed the etiologic agent was microsporum audouinii. we present this case because of its rarity in our country and we point out the increasing interest of the imported tineas due to immigration from african countries.200115487914
tinea capitis in infants in their first year of life.tinea capitis is the most common type of dermatophytosis in children, but is uncommon in the first year of life.200415491432
stereoselective synthesis and antifungal activity of (z)-trans-3-azolyl-2-methylchromanone oxime ethers.a series of (z)-trans-3-azolyl-2-methylchromanone oxime ethers were stereoselectively synthesized and tested for in vitro antifungal activity. many of these derivatives exhibit high activity against candida albicans, saccharomyces cerevisiae, aspergillus niger, and microsporum gypseum.200415498664
tinea capitis caused by microsporum canis treated with terbinafine.tinea capitis is a disease found throughout the world. it frequently affects children and only rarely adults, usually post-menopausal women. numerous dermatophytes of the genus microsporum and tricophyton can cause tinea capitis and griseofulvin is still today the treatment of choice. to study the effectiveness and tolerability of terbinafine treatment in tinea capitis caused by microsporum canis we treated 26 patients - 22 children and four women - for a period of 12 weeks. dosage adopted was 6 ...200415504128
bizarre annular lesion emerging as tinea incognito.tinea incognito has first been described in 1968. the term describes a tinea infection whose clinical morphology has been modified by the application of topical corticosteroids. the clinical manifestation can masquerade a number of other dermatoses and leads to misdiagnosis of annular eruptions. we describe a patient who showed a bizarre appearance of annular, inflammatory skin lesions at the umbilical region. mycological culture yielded microsporum canis.200415504132
griseofulvin versus terbinafine in the treatment of tinea capitis: a meta-analysis of randomized, clinical trials.tinea capitis, a common pediatric infection in the united states, is caused mainly by trichophyton species and affects many urban children. although the current treatment of choice is oral griseofulvin, terbinafine has been shown to be variably effective in several comparative, randomized trials. the purpose of this study was to perform a meta-analysis of randomized, clinical trials comparing the efficacies of oral terbinafine and oral griseofulvin for the treatment of childhood tinea capitis.200415520113
diversity of keratinophilic mycoflora in the soil of agra (india).diversity of keratinophilic mycoflora in the soil of agra was under observation for 1 year (july 2001-june 2002) and isolation of keratinophilic fungi was followed by the hair-baiting method. the frequency of occurrence of keratinophilic fungi in 284 soil samples collected from various hospitals, cattle yards, poultry farms, crop fields and playgrounds was determined, 204 samples (72%) having been found to be positive. a total of 33 species classified into 11 genera (acremonium, aspergillus, chr ...200415530009
myths and misconceptions: not all that glitters under the watch is gold (nickel) dermatitis. 200415538087
clinical and epidemiological study in an aids patient with microsporum gypseum infection.a 37 years old homosexual male with aids was diagnosed as having tinea cruris and tinea corporis. the patient was a garden designer and therefore he used to handle soil very often. microsporum gypseum was identified on cultures from skin-scrapings and biopsy material taken from different cutaneous lesion. the same species was isolated from samples of soil the patient used to work with. the clinical history of the patient and its epidemiological aspects were deeply studied by the authors. we stre ...199715538824
antimicrobial and free radical scavenging activity of gentianella nitida.the antimicrobial and free radical scavenging activity of the ethanol extract and fractions of gentianella nitida have been assessed. the most susceptible microorganisms were candida albicans, trichophyton mentagrophytes and microsporum gypseum. the antifungal activity was concentrated in the 90% methanol and nonsoluble fractions, while the radical scavenging activity was stronger in the ethyl acetate and nonsoluble fractions.200415567257
efficacy of pre-treatment with lufenuron for the prevention of microsporum canis infection in a feline direct topical challenge model.oral lufenuron is reportedly an effective treatment for some cats with dermatophytosis. the purpose of this study was to determine if lufenuron, when used as a pre-treatment prior to challenge exposure, would be protective against the development of infection after the direct topical application of fungal macrocondia (microsporum canis spores). three groups (n = 6/group) of juvenile cats were treated with either monthly oral lufenuron (30 or 133 mg/kg) or placebo. after 2 months of treatment, ki ...200415585010
in vitro evaluation of griseofulvin against clinical isolates of dermatophytes from isfahan.fifty dermatophyte isolates, recently obtained from clinical materials, belonging to trichophyton mentagrophytes, t. verrucosum, microsporum canis and epidermophyton floccosum were examined for their susceptibility to griseofulvin. the minimum inhibitory concentration (mic) values were obtained using the modified microdilution method. all 100% tested isolates had mic geometric mean at a concentration between 0.43 and 0.95 microg ml(-1) the mic(90)s and mic(50)s were 8 microg ml(-1) and <0.25-1 m ...200415601457
the epidemiology of canine and feline dermatophytoses in southern italy.a total of 424 animals (268 dogs and 156 cats) with skin lesions (alopecia and peripheral scaling) were examined from january 1999 to december 2002. of the 424 samples examined, 99 (23.3%) yielded a positive culture and, in particular, 20.5% of the dog samples and 28.2% of the cat samples. microsporum canis was the most common dermatophyte isolated from dogs and cats (77.7%), followed by geophilic dermatophyte species (m. gypseum, trichophyton terrestre). young dogs and cats, especially those yo ...200415601458
evaluation of inhibitory effect of the plant phyllanthus amarus against dermatophytic fungi microsporum gypseum.the antifungal activity of various solvent extracts (such as ether, chloroform, ethyl acetate and ethyl alcohol) of the plant phyllanthus amarus against dermatophytic fungi microsporum gypseum was observed.200415602834
keratinophilic fungi of poultry farm and feather dumping soil in tamil nadu, india.soils of 10 poultry farms from namakkal and 12 feather dumping sites from chennai were studied for the presence of keratinophilic fungi. a total of 34 species belonging to 19 genera and one non-sporulating fungus were recovered. sixteen species of fungi and one non-sporulating fungi were common to both sites, eight species were specific to namakkal and nine species were specific to chennai. dermatophytes and closely related fungi were represented by six species belonging to five genera. fungal s ...200415645172
isatin-derived antibacterial and antifungal compounds and their transition metal complexes.a series of isatins incorporating thiazole, thiadiazole, benzothiazole and p-toluene sulfonyl hydrazide moieties, along with their cobalt(ii), copper(ii), nickel(ii) and zinc(ii) metal complexes have been synthesized and characterized by elemental analyses, molar conductances, magnetic moments, ir, nmr and electronic spectral data. these compounds have been screened for antibacterial activity against escherichia coli, bacillus subtillis, shigella flexneri, staphylococcus aureus, pseudomonas aeru ...200415648656
[inflammatory lesion with a black scab on the face of a 16-year old girl]. 200515657728
use of magnetic beads to extract fungal dna.authors compare two methods of extracting dna from different fungi: the classic method with phenol/chloroform (p/c) and that with magnetic beads. both were tested on candida albicans and cryptococcus neoformans var. neoformans, belonging to the yeast group and microsporum canis, m. gypseum, trichophyton rubrum, t. interdigitale, t. ajelloi, epidermophyton floccosum, belonging to the dermatophytes group. extraction products underwent polymerase chain reaction (pcr) fingerprinting with the appropr ...200515679657
tinea capitis in diyarbakir, turkey.the incidence and types of tinea capitis in 234 children aged 1-12 referred to our laboratory with a preliminary diagnosis of tinea capitis infection in the past 5 years were investigated. tinea capitis was determined in 149 (63.7%) of these patients, of which agents grew in culture in 124 (83.2%). the most frequently isolated agents, in order of frequency, are as follows: trichophyton violaceum (43.6%), microsporum canis (37.9%), t. mentagrophytes (8.1%) and t. verrucosum (4.8%).200515679658
epidemiology of dermatomycoses in children living in northern greece 1996-2000.in the 5-years period, 1996-2000, 1045 children under 13 years old were examined for suspected dermatomycosis. in 611 cases fungi were isolated. male children were mainly affected on the scalp and body area. girls were more affected in the location of the arms and legs. there was a greater proportion of cases in the age range 2-12 years. the most prominent fungus was microsporum canis (515 cases) followed by trichophyton rubrum (34) and candida albicans (20). tinea capitis (280 cases) mainly cau ...200515679659
characteristics of dermatophytoses among children in an area south of tehran, iran.the aim of this study was to determine the prevalence and etiological agents of dermatophytoses, and also their distribution according to age, gender, and body site among children in an area south of tehran. a total of 382 children aged </=16 years suspected to have dermatophytic lesions were examined over a period of 3 years (1999-2001). the incidence rate of dermatophytoses was 6.6 per 100 000 person-years. trichophyton violaceum was the most frequent isolate (28.3%) followed by microsporum ca ...200515679663
dermatophytosis on the eyelid caused by microsporum gypseum.we report a case of tinea on the eyelid in a woman with psoriasis. due to the history of psoriasis and clinical aspect of the lesion the diagnosis of psoriasis was suggested in the first place; however, laboratory examination revealed microsporum gypseum. the patient was treated with oral itraconazole resulting in clinical and mycological cure. we emphasize the uncommon location of tinea caused by m. gypseum and the importance of searching for fungal infection on scaly lesions.200515679671
evaluation of microsporum canis in different methods of storage.the main objective of this investigation was to evaluate different methods of storage for microsporum canis based on materials and equipment that are readily available in developing countries. we tested 32 strains of m. canis at - 20 degrees c in potato dextrose agar (pda) in its plain condition, or amended with 10% dimethyl sulfoxide or with 10% glycerol. in addition, we tested 25 degrees c storage of isolates in plain saline (0.9% nacl) and in saline covered with a mineral-oil layer. after 9 m ...200415682637
[dermatophyte species isolated from patients prediagnosed as onychomycosis and the value of fungal culture].in this study, the clinical specimens taken from 390 patients who were prediagnosed as onychomycosis have been investigated by direct microscopy and culture methods, in the mycology unit of central laboratory of kocaeli university medical faculty. twenty-one (41.2%) of the 51 microscopically positive samples revealed positive cultures for dermatophytes, whereas 32 (9.4%) samples were culture positive among the 399 samples which were microscopically negative. the most frequently isolated dermatop ...200415700670
[investigation of the inter-observer agreement rates for morphometric evaluation of the growth of microsporum canis colonies].morphometry is a newly applied method for investigation of the in-vitro growth dynamics of dermatophyte colonies. this study was undertaken to evaluate the correlation and agreement rates between the morphometric data obtained by different observers. for this purpose, five different microsporum canis growth data were evaluated by six observers. the results of the study suggested that the agreement rates among the data obtained by different observers were low (r1 = -5.3509), while the results obt ...200415700671
in vitro antifungal activity of dragon's blood from croton urucurana against dermatophytes.based on ethnobotanical approach, the dragon's blood collected from croton urucurana baill. bark (euphorbiaceae) was tested for antifungal activity against five dermatophytes by paper disk diffusion method. the minimal inhibitory concentration (mic) showing no visible fungal growth was also determined, using tube dilution technique. the test dermatophytes were tricophyton tonsurans, trichophyton mentagrophytes, trichophyton rubrum, microsporum canis and epidermophyton floccossum. the dragon's bl ...200515707783
[dermatophytoses due to microsporum gypseum: report of eight cases and literature review].microsporum gypseum is a geophilic fungus infrequent agent of human dermatophytoses and world-wide in distribution. in cadiz, spain, between 1997 and 2003, a study of 133 positive cases showed that the fifth more isolated dermatophyte was m. gypseum (6.0%), followed by trichophyton mentagrophytes (24,8%), microsporun canis (24,6%), trichophyton rubrum (21,8%) y trichophyton violaceum (6,8%). during 2003 the infection due to this fungus has been repeatedly observed in our area (17.5%). we report ...200415709790
comparison of disk diffusion method and broth microdilution method for antifungal susceptibility testing of dermatophytes.the use of the agar diffusion neo-sensitabs method to determine antifungal susceptibility of 59 isolates of dermatophytes, namely epidermophyton floccosum, microsporum canis, m. gypseum, trichophyton mentagrophytes, t. rubrum and t. tonsurans to clotrimazole (clz), itraconazole (itz) and terbinafine (tbf) is described. results obtained are compared to the minimum inhibitory concentrations (mic) determined by an adaptation of the nccls-m38-a procedure. using the diffusion method, all strains show ...200515712608
new triorganotin(iv) derivatives of dipeptides as anti-inflammatory-antimicrobial agents.new triorganotin(iv) derivatives of dipeptides with general formulae r(3)sn(hl), where r = me and/or n-bu and/or ph and hl is the monoanion of glycylglycine (h(2)l-1), glycylvaline (h(2)l-2), glycylleucine (h(2)l-3), glycyltryptophane (h(2)l-4) and glycyltyrosine (h(2)l-5) have been synthesized and characterized on the basis of infrared, multinuclear nmr and (119)sn mossbauer spectroscopic studies. all the newly synthesized compounds were examined for their in vivo anti-inflammatory activity (us ...200515725498
keratinophilic fungi isolated from hospital dust and soils of public places at gulbarga, india.keratinophilic fungi were isolated from corridor dust of 11 hospitals and soils of 21 public places using a hair baiting technique. a total of 41 species belonging to 24 genera were recovered. among the dermatophytes and related species, microsporum gypseum was predominant, followed by chrysosporium keratinophilum, trichophyton mentagrophytes, m. nanum and ch. tropicum. other species were represented by 32 species belonging to 21 genera. most of the species isolated are known to be agents of hum ...200515750728
[animal dermatophytosis. recent advances].the proportion of positive samples in relation to the number of samples examined from cases of dog and cat dermatophytosis varies considerably from one investigation to another. in dogs, it ranges between 4% and 10% and few studies show higher prevalences. on the other hand, the percentages of positive cultures cited in the reviewed literature from dogs with or without suspected dermatophytosis are quite similar. in dogs with suspected lesions of dermatophytosis, with few exceptions, microsporum ...200015762784
tinea capitis: a treatment update.currently, many experts consider griseofulvin to be the drug of choice for tinea capitis. it is fda approved for this indication, highly efficacious, and has an excellent long-term safety record. nonetheless, there is now ample evidence documenting the efficacy and safety of other antifungal agents. terbinafine, itraconazole, and fluconazole have been used off-label in the united states and united kingdom for tinea capitis. several studies have shown that short-term terbinafine, itraconazole, or ...200515792111
in vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species.the in vitro activities of two new triazole antifungal agents with broad-spectrum antifungal activity, posaconazole and ravuconazole, were compared with those of three well-established antifungal agents, terbinafine, itraconazole and fluconazole, against 184 clinical isolates. these included 129 dermatophyte isolates (twelve species), 25 yeast isolates (five species) and 28 non-dermatophyte isolates (nine species). in vitro testing was conducted using microdilution plates with rpmi 1640 and nati ...200515832561
scutular tinea of the scrotum: report of two cases.infections caused by dermathophytes in the scrotal skin are uncommon especially due to microsporum gypseum, which may form scutular or favus-like lesions. we report two patients with this type of tinea: one immune suppressed by hiv infection and another immunocompetent without comorbidity. in the literature we found only two reports in immunocompetent patients and some in immune suppressed with similar symptoms.200515842330
antifungal activity of ocimum gratissimum towards dermatophytes.the development of more effective and less toxic antifungal agents is required for the treatment of dermatophytosis. plants and their preparations have been used as medicines against infectious diseases. extracts of ocimum gratissimum leaves were investigated for in vitro antifungal activity, using agar dilution technique against dermatophytes. the extracts (hexane, chloroform fractions, the essential oil and eugenol) produced antifungal activities against microsporum canis, m. gypseum, trichoph ...200515842332
dermatophyte infections in the ljubljana region, slovenia, 1995-2002.we studied dermatophyte infections in patients, examined in the mycological laboratory of the department of dermatology, university medical centre ljubljana during the period 1995-2002. a total of 42,494 samples were collected from 33,974 patients suspected to have dermatomycosis. dermatophytes were identified in 8286 (71.2%) positive cultures. microsporum canis was the most frequent dermatophyte isolated (46.8%), followed by trichophyton rubrum (36.7%), t. mentagrophytes var. interdigitale (7.9 ...200515842334
development of an enzyme-linked immunosorbant assay (elisa) for the serodiagnosis of canine dermatophytosis caused by microsporum canis.abstract in dogs, dermatophytosis should be considered in any case of alopecic, papular or pustular lesion. the aim of this study was to develop an enzyme-linked immunosorbant assay (elisa) as an aid in the diagnosis of canine dermatophytosis. the antigen used was a whole fungal extract obtained from an isolate of microsporum canis cultured on a liquid medium from the parasitized hair of a cat with patches of alopecia. to assess the elisa performances, sera from 18 dogs with dermatophytosis caus ...200515842540
inhibitory effect of the plant boerhavia diffusa l. against the dermatophytic fungus microsporum fulvum.antifungal activity (reduction in colony diameter) of various extracts (pt. ether, chloroform, ethyl acetate, ethyl alcohol and aqueous) of aerial and root parts of boerhavia diffusa (nictaginaceae) was screened against dermatophytic fungi microsporum fulvum. statistically significant increase has been recorded in the % inhibition of the target fungal species with increasing test concentrations (1000-5000 ppm) of chloroform, ethyl acetate and ethyl alcohol extracts of the root. the maximum % inh ...200415847339
mycoses in thailand: current concerns.scytalidium dimidiatum is the leading cause of fungal foot diseases in thailand, in contrast to similar studies in which dermatophytes have been identified as the predominant pathogens. by contrast, the prevalence of candida albicans in our study was only 2.6 approximately 3.0%. scytalidium fungal foot infection is clinically indistinguishable from that caused by dermatophytes and should be included as a possible cause of treatment failure in tinea pedis and onychomycosis. without proper culture ...200515864252
once-weekly fluconazole in children with tinea capitis due to microsporum canis. 200515868642
repetitive-sequence-pcr-based dna fingerprinting using the diversilab system for identification of commonly encountered dermatophytes.the performance of repetitive-sequence-based pcr (rep-pcr) using the diversilab system for identification of dermatophytes commonly isolated in a clinical laboratory was assessed by comparing results to those of conventional tests (colony morphology, microscopic examination of slide cultures, and, for suspected trichophyton species, use of additional media). sixty-one cultures were tested in phase 1, the feasibility portion of the study; 64 additional cultures were tested in phase 2, the validat ...200515872233
production of heptaene antifungal antibiotic by streptomyces purpeofuscus cm 1261.a strain of streptomyces purpeofuscus cm 1261 isolated from a sample of compost collected locally was found to possess strong antagonistic activity against 4 human pathogenic fungi i.e., candida albicans, aspergillus niger, microsporum gypseum and trichophyton sp. the active antifungal compound produced by it was found to be a heptaene group of polyene antifungal antibiotic.200515875718
in vitro susceptibility testing of microsporum gypseum isolated from healthy cattle and soil samples against itraconazole, terbinafine, fluconazole and topical veterinarian drugs.the present study evaluated in vitro susceptibility testing of dermatophytes isolates from healthy cattle and soil samples against three antifungal agents and three topical veterinarian drugs. itraconazole and terbinafine showed a higher in vitro fungicidal activity than fluconazole. the veterinarian drugs lepecid and iodine 5% were more active in vitro than the unguento spray. all drugs showed fungicidal activity against microsporum gypseum, and they may be considered as efficient agents for th ...200515883722
etiologic agents of dermatophyte infection in lebanon.dermatophytes are common and cause important human fungal infections in many parts of the world, including lebanon. the prevalence of these fungi, however, tends to vary with time and geographic location. in our region, studies on the prevalence of dermatophytoses and the distribution of the various dermatophyte species involved are rare. in lebanon, only one study was published on this subject over the last forty years.200415884683
antifungal activities of six south african terminalia species (combretaceae).a serial microplate dilution method developed for bacteria was modified slightly and gave good results with several fungi. the antifungal activity of acetone, hexane, dichloromethane and methanol leaf extracts of six terminalia species (terminalia prunioides, terminalia brachystemma, terminalia sericea, terminalia gazensis, terminalia mollis and terminalia sambesiaca) were tested against five fungal animal pathogens (candida albicans, cryptococcus neoformans, aspergillus fumigatus, microsporum c ...200515894142
organometallic-based antibacterial and antifungal compounds: transition metal complexes of 1,1'-diacetylferrocene-derived thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone.organometallic-based, 1,1'-diacetylferrocene-derived antibacterial and antifungal thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone have been prepared by condensing equimolar amount of 1,1'-diacetylferrocene with thiocarbohydrazide, carbohydrazide thiosemicarbazide and semicarbazide, respectively. these were used as ligands for the preparation of their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) metal complexes. all the synthesized ligands and their complexes were c ...200515895689
therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole.tinea capitis is a relatively common fungal infection of childhood. griseofulvin has been the mainstay of treatment for many years. however, newer oral antifungal agents are being used more frequently.200515897167
antidermatophyte activity of ether extract of nigella sativa and its active principle, thymoquinone.the antifungal activity of ether extract of nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of trichophyton rubrum and one each of trichophyton interdigitale, trichophyton mentagrophytes, epidermophyton floccosum and microsporum canis. agar diffusion method with serial dilutions of ether extract of nigella sativa, thymoquinone and griseofulvin was employed. the incubation was carried out at 30 degrees c for 14 days. the di ...200515908151
fluconazole upregulates sconc expression and inhibits sulphur metabolism in microsporum canis.azole derivatives such as fluconazole are the mainstay of therapeutic agents for the treatment of fungal infections. their mode of action involving alteration in the conversion of lanosterol to ergosterol is well established. here we report the effect of fluconazole on the sulphur metabolism negative regulator gene (sconc) in microsporum canis. characterization of the m. canis sconc gene revealed that its orf is comprised of 495bp interrupted by four introns of 47-70bp. exposure of m. canis in s ...200515922636
[incidence, immunity and treatment of feline dermatophytosis].feline dermatophytosis is a superficial skin infection characterized by the invasion of cornified tissues such as hair and nails. this infection is nearly always caused by microsporum canis. infected animals release infective spores in the environment which will then contaminate other animals or humans. infected animals usually develop immunity so the infection will spontaneously disappear after a few weeks to months. long haired and immunocom-promised cats do not have the same ability to acquir ...200515929601
[evaluation the antimycotic activity of itraconazole in human stratum corneum with vitro fungi cultivation].to establish a new model to evaluate the antifungal activity of antimycotics.200515949332
in-vitro antibacterial, antifungal and cytotoxic properties of sulfonamide--derived schiff's bases and their metal complexes.a series of new antibacterial and antifungal schiff's bases derived from sulfonamides, as well as their transition metal complexes incorporating cobalt (ii), copper (ii), nickel (ii) and zinc (ii) were synthesized, characterized and screened for their in-vitro antibacterial activity against six gram-negative (escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi and shigella dysentriae) and four gram-positive (bacillus cereus, corynebacterium diphth ...200515968823
inter-single-sequence-repeat-pcr typing as a new tool for identification of microsporum canis strains.microsporum canis is a ubiquitous dermatophyte that commonly causes human infections. since contact with infected animals is the usual way of infection, tracing its source is an essential preventive measure.200515978415
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