Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| effect of cdnb on filarial thioredoxin reductase : a proteomic and biochemical approach. | thioredoxin reductase plays a crucial role in the maintenance of cellular redox homeostasis. in this study, we have targeted trxr in setaria cervi, a bovine filarial parasite using its inhibitor cdnb. it caused significant decrease in the motility and viability of these parasites leading to their death. inhibition of trxr leads to the downregulation of the antioxidant system followed by generation of oxidative stress in these parasites. the increased ros level induced lipid peroxidation and prot ... | 2015 | 25463268 |
| [lymphatic filariasis transmission assessment survey in schools three years after stopping mass drug treatment with albendazole and ivermectin in the 7 endemic districts in togo]. | the aim of this study is to verify the level of transmission of lymphatic filariasis three years after stopping mass drug treatment in the 7 endemic districts in togo. the survey was conducted in 2012 in togo's 7 endemic districts grouped into four evaluation units (eu) using the who-recommended transmission assessment survey (tas) protocol. children aged 6-7 years were screened for wuchereria bancofti antigen using the immunochromatographic card (ict) method. a cluster sampling method was used ... | 2015 | 25476256 |
| species composition and temporal distribution of mosquito populations in ibadan, southwestern nigeria. | nigeria has a high burden of vector borne diseases such as malaria and lymphatic filariasis (lf). this study aimed to determine the species composition of mosquitoes in ibadan, southwest nigeria as well as determine their role in malaria and lf transmission. adult mosquitoes were collected by pyrethrum spray catch (psc) and identified and graded according to their abdominal conditions. the mosquitoes were dissected to determine the parity status and to check for microfilariae of wuchereria bancr ... | 0 | 25520960 |
| macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. | parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. a better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate infection-associated morbidity. murine resistin-like molecules (relm) exhibit pleiotropic functions following helminth infection including modulating the host immune response; however, the relevance of human relm proteins in helminth infection is unkno ... | 2015 | 25568944 |
| imported lymphatic filariasis in an indian immigrant to iran. | lymphatic filariasis (lf), a nematode disease transmitted by arthropod vectors, is repeatedly reported in immigrant population. this disease is not endemic in iran; however, different species of mosquitoes, capable of transmission of parasite microfilaria, are distributed in the country. hereby, incidental detection of an imported case of lf due to wuchereria bancrofti in an indian worker in iran is reported. identification of the case was performed based on morphological and morphometrical char ... | 0 | 25642273 |
| incidental diagnosis of filariasis in superficial location by fnac: a retrospective study of 10 years. | filariasis, transmitted by the bite of various species of mosquito, is a common disease of tropical belt of the world. in south east asia, including india, it is a major public health problem. the parasite is primarily confined to lymphatic channel or lymph nodes where it can remain viable for more than two decades. the most common presentation of the disease is asymptomatic/ subclinical microfilaremia, hydrocele, acute adeno-lymphangitis (adl) and chronic lymphatic disease. however, the disease ... | 2014 | 25653954 |
| targeting filarial abl-like kinases: orally available, food and drug administration-approved tyrosine kinase inhibitors are microfilaricidal and macrofilaricidal. | elimination of onchocerciasis and lymphatic filariasis is targeted for 2020. given the coincident loa loa infections in central africa and the potential for drug resistance development, the need for new microfilaricides and macrofilaricides has never been greater. with the genomes of l. loa, onchocerca volvulus, wuchereria bancrofti, and brugia malayi available, new drug targets have been identified. | 2015 | 25657255 |
| blastic phase of cml with microfilaria: a rare case report. | filariasis is a major public health concern in tropical and subtropical countries including india. there have been very few case reports of incidental filariasis in the bone marrow aspirate smears in patients with hematological malignancies. we present a case of blastic phase of chronic myeloid leukemia (cml) with associated filariasis with monocytosis. such an association, to the best of our knowledge, is hitherto unreported. moreover, eosinophilia was not a feature in our case. a 37-year-old m ... | 2015 | 25737999 |
| xenomonitoring of different filarial nematodes using single and multiplex pcr in mosquitoes from assiut governorate, egypt. | wuchereria bancrofti, dirofilaria immitis, and dirofilaria repens are filarial nematodes transmitted by mosquitoes belonging to culex, aedes, and anopheles genera. screening by vector dissection is a tiresome technique. we aimed to screen filarial parasites in their vectors by single and multiplex pcr and evaluate the usefulness of multiplex pcr as a rapid xenomonitoring and simultaneous differentiation tool, in area where 3 filarial parasites are coexisting. female mosquitoes were collected fro ... | 2015 | 25748712 |
| the impact of two semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in the republic of congo. | implementation of mass drug administration (mda) with ivermectin plus albendazole (alb) for lymphatic filariasis (lf) has been delayed in central africa because of the risk of serious adverse events in subjects with high loa loa microfilaremia. we conducted a community trial to assess the impact of semiannual mda with alb (400 mg) alone on lf and soil-transmitted helminth (sth) infections in the republic of congo. evaluation at 12 months showed that alb mda had not significantly reduced wucherer ... | 2015 | 25758650 |
| a randomized controlled trial of increased dose and frequency of albendazole with standard dose dec for treatment of wuchereria bancrofti microfilaremics in odisha, india. | although current programmes to eliminate lymphatic filariasis have made significant progress it may be necessary to use different approaches to achieve the global goal, especially where compliance has been poor and 'hot spots' of continued infection exist. in the absence of alternative drugs, the use of higher or more frequent dosing with the existing drugs needs to be explored. we examined the effect of higher and/or more frequent dosing with albendazole with a fixed 300 mg dose of diethylcarba ... | 2015 | 25781977 |
| elimination of lymphatic filariasis in the gambia. | the prevalence of wuchereria bancrofti, which causes lymphatic filariasis (lf) in the gambia was among the highest in africa in the 1950s. however, surveys conducted in 1975 and 1976 revealed a dramatic decline in lf endemicity in the absence of mass drug administration (mda). the decline in prevalence was partly attributed to a significant reduction in mosquito density through the widespread use of insecticidal nets. based on findings elsewhere that vector control alone can interrupt lf, we ask ... | 2015 | 25785587 |
| treatment of w. bancrofti (wb) in hiv/wb coinfections in south india. | the disease course of human immunodeficiency virus (hiv) is often altered by existing or newly acquired coincident infections. | 2015 | 25793933 |
| a bibliometric profile of lymphatic filariasis research in india. | tropical and vector borne diseases have always been a challenge for the medical science and society and exerted high impact on society in terms of financial, economical and psychological relevance. lymphatic filariasis (lf) is one of the tropical diseases which is prevalent in under developing and developed countries. the objective of this study is to analyze the literature published in the area of filariasis research. the focus is to see the indian contribution and its impact in terms of global ... | 2015 | 25815870 |
| distribution and risk factors for plasmodium and helminth co-infections: a cross-sectional survey among children in bagamoyo district, coastal region of tanzania. | plasmodium and soil transmitted helminth infections (sth) are a major public health problem, particularly among children. there are conflicting findings on potential association between these two parasites. this study investigated the plasmodium and helminth co-infections among children aged 2 months to 9 years living in bagamoyo district, coastal region of tanzania. | 2015 | 25837022 |
| randomised controlled clinical trial of increased dose and frequency of albendazole and ivermectin on wuchereria bancrofti microfilarial clearance in northern malawi. | in africa, albendazole and ivermectin are currently used in combination for annual mass drug administration (mda) for lymphatic filariasis (lf) elimination. rapid and sustained clearance is desirable for public health impact and elimination of lf. increasing the dose and/or frequency of albendazole and ivermectin treatment may be more effective in clearing microfilariae than standard mda. | 2015 | 25877874 |
| sibling species of the anopheles funestus group, and their infection with malaria and lymphatic filarial parasites, in archived and newly collected specimens from northeastern tanzania. | studies on the east african coast have shown a recent dramatic decline in malaria vector density and change in composition of sibling species of the anopheles gambiae complex, paralleled by a major decline in malaria incidence. in order to better understand the ongoing changes in vector-parasite dynamics in the area, and to allow for appropriate adjustment of control activities, the present study examined the composition, and malaria and lymphatic filarial infection, of sibling species of the an ... | 2015 | 25885457 |
| setaria digitata in advancing our knowledge of human lymphatic filariasis. | setaria digitata is a filarial parasite that causes fatal cerebrospinal nematodiasis in goats, sheep and horses, resulting in substantial economic losses in animal husbandry in the tropics. due to its close resemblance to wuchereria bancrofti, this nematode is also frequently used as a model organism to study human lymphatic filariasis. this review highlights numerous insights into the morphological, histological, biochemical, immunological and genetic aspects of s. digitata that have broadened ... | 2016 | 25924635 |
| a systematic study on structure and function of atpase of wuchereria bancrofti. | analyzing the structures and functions of different proteins of wuchereria bancrofti is very important because till date no effective drug or vaccine has been discovered to treat lymphatic filariasis (lf). atpase is one of the most important proteins of wuchereria bancrofti. adenosine triphosphate (atp) converts into adenosine diphosphate (adp) and a free phosphate ion by the action of these atpase enzymes. energy releases from these dephosphorylation reactions drive the other chemical reactions ... | 2017 | 25948965 |
| evaluation of traps and lures for mosquito vectors and xenomonitoring of wuchereria bancrofti infection in a high prevalence samoan village. | elimination of lymphatic filariasis (lf) in samoa continues to be challenging despite multiple annual mass drug campaigns aimed at stopping transmission by reducing the prevalence and density of microfilaraemia. the persistence of transmission may be partly related to the highly efficient aedes vectors. the assessment of pathogen transmission by mosquito vectors and of vector control relies on the ability to capture mosquitoes efficiently. the aims of this study are to compare trapping methods t ... | 2015 | 26016830 |
| rapid point-of-contact tool for mapping and integrated surveillance of wuchereria bancrofti and onchocerca volvulus infection. | elimination programs for wuchereria bancrofti and onchocerca volvulus are in critical need of sensitive, specific, and point-of-contact (poc) tools that can be used for surveillance years beyond cessation of mass drug administration when infection intensities are low. previously, wb123 and ov16 were identified individually as potential filarial antigens for an antibody-based poc test. the present study compares single-antigen wb123- and ov16-based poc tests with an integrated configuration to de ... | 2015 | 26018537 |
| the impact of six annual rounds of mass drug administration on wuchereria bancrofti infections in humans and in mosquitoes in mali. | wuchereria bancrofti prevalence and transmission were assessed in six endemic villages in sikasso, mali prior to and yearly during mass drug administration (mda) with albendazole and ivermectin from 2002 to 2007. microfilaremia was determined by calibrated thick smear of night blood in adult volunteers and circulating filarial antigen was measured using immunochromatographic card test in children < 5 years of age. mosquitoes were collected by human landing catch from july to december. none of th ... | 2015 | 26033027 |
| refractory chyluria due to filariasis. | 2015 | 26048257 | |
| epidemiology of elephantiasis with special emphasis on podoconiosis in ethiopia: a literature review. | elephantiasis is a symptom of a variety of diseases that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts. some conditions having this symptom include: elephantiasis nostras, due to longstanding chronic lymphangitis; elephantiasis tropica or lymphatic filariasis, caused by a number of parasitic worms, particularly wuchereria bancrofti; non-filarial elephantiasis or podoconiosis, an immune disease caused by heavy metal ... | 2015 | 26119541 |
| chyluria: a scourge of our region. | chyluria is endemic in the gangetic belt of india with an average of 90 cases treated annually at our institute. it is almost exclusively caused by wuchereria bancrofti in tropical areas. chylomicrons and triglycerides are lost in the urine from an abnormal lymphourinary fistula due to obstructive lymphatic stasis, most commonly at the renal pelvis. it is a distressingly recurrent condition with multiple exacerbations and remissions over years. severe weakness, weight loss and haematuria occur i ... | 2015 | 26150622 |
| a comparison of two tests for filarial antigenemia in areas in sri lanka and indonesia with low-level persistence of lymphatic filariasis following mass drug administration. | filarial antigen tests are key tools for mapping the distribution of bancroftian filariasis and for detecting areas with persistent infections following mass drug administration (mda). a recent study showed that the new alere filariasis test strip (fts) has better analytical sensitivity than the binaxnow filariasis card test (card test) for detecting circulating filarial antigen, and the fts detected more positive results than the card test in a field study performed in a highly endemic area in ... | 2015 | 26168919 |
| recurrent hemorrhagic pericardial effusion and tamponade due to filariasis successfully treated with ivermectin and albendazole. | filariasis presenting with pericardial effusion with tamponade is rare. we report a case of a 30-year-old female who was admitted with severe dyspnea and chest pain since 2 days. echocardiogram showed massive pericardial effusion with tamponade. pericardial fluid aspiration drained 1.2 l of hemorrhagic fluid. cytology examination revealed microfilaria of wuchereria bancrofti. she was treated with diethyl carbamazine and discharged. six weeks later, she presented again with massive pericardial ef ... | 2017 | 26240733 |
| rapid differentiation of filariae in unstained and stained paraffin-embedded sections by a high-resolution melting analysis pcr assay. | apart from infection with human filariae, zoonotic filariasis also occurs worldwide, and the numbers of cases have been increasing steadily. diagnosis of intact filariae in tissues or organs depends on histological identification. the morphology of parasites in tissue-embedded sections is poor and shows high levels of homoplasy. thus, the use of morphological characteristics in taxonomic studies is difficult and may not allow a specific diagnosis. | 2015 | 26273808 |
| comparison of methods for xenomonitoring in vectors of lymphatic filariasis in northeastern tanzania. | monitoring wuchereria bancrofti infection in mosquitoes (xenomonitoring) can play an important role in determining when lymphatic filariasis has been eliminated, or in focusing control efforts. as mosquito infection rates can be low, a method for collecting large numbers of mosquitoes is necessary. gravid traps collected large numbers of culex quinquefasciatus in tanzania, and a collection method that targets mosquitoes that have already fed could result in increased sensitivity in detecting w. ... | 2015 | 26350454 |
| evaluation of human and mosquito based diagnostic tools for defining endpoints for elimination of anopheles transmitted lymphatic filariasis in ghana. | the decision to stop mass drug administration (mda) and monitor recrudescence has to be made when endpoints for elimination of lymphatic filariasis (lf) have been achieved. highly sensitive and specific diagnostic tools are required to do this. the main objective of this study was to determine most effective diagnostic tools for assessing interruption of lf transmission. | 2015 | 26385935 |
| the impact of residual infections on anopheles-transmitted wuchereria bancrofti after multiple rounds of mass drug administration. | many countries have made significant progress in the implementation of world health organization recommended preventive chemotherapy strategy, to eliminate lymphatic filariasis (lf). however, pertinent challenges such as the existence of areas of residual infections in disease endemic districts pose potential threats to the achievements made. thus, this study was undertaken to assess the importance of these areas in implementation units (districts) where microfilaria (mf) positive individuals co ... | 2015 | 26399968 |
| assessing the presence of wuchereria bancrofti in vector and human populations from urban communities in conakry, guinea. | the global programme to eliminate lymphatic filariasis was launched in 2000 with the goal of interrupting transmission of lymphatic filariasis (lf) through multiple rounds of mass drug administration (mda). in guinea, there is evidence of ongoing lf transmission, but little is known about the most densely populated parts of the country, including the capital conakry. in order to guide the lf control and elimination efforts, serological and entomological surveys were carried out to determine whet ... | 2015 | 26410739 |
| genome filtering for new dna biomarkers of loa loa infection suitable for loop-mediated isothermal amplification. | loa loa infections have emerged as a serious public health problem in patients co-infected with onchocerca volvulus or wuchereria bancrofti because of severe adverse neurological reactions after treatment with ivermectin. accurate diagnostic tests are needed for careful mapping in regions where mass drug administration is underway. loop-mediated isothermal amplification (lamp) has become a widely adopted screening method because of its operational simplicity, rapidity and versatility of visual d ... | 2015 | 26414073 |
| evaluation of mass drug administration in the program to control imported lymphatic filariasis in thailand. | migration plays a major role in the emergence and resurgence of lymphatic filariasis (lf) in many countries. because of the high prevalence of imported bancroftian filariasis (ibf) caused by nocturnally periodic wuchereria bancrofti and the intensive movement of immigrant workers from endemic areas, thailand has implemented two doses of 6 mg/kg diethylcarbamazine (dec) with interval of 6 months to prevent ibf. in areas where immigrants are very mobile, the administration of dec may be compromise ... | 2015 | 26415693 |
| microfilarial periodicity of wuchereria bancrofti in assam, northeast india. | wuchereria bancrofti has shown nocturnal periodicity in india and other endemic countries of the world except pacific regions where non-periodic or diurnal sub-periodic forms have been reported. presence of sub-periodic form of w. bancrofti in andaman and nicobar islands, india and a case report of sub- periodic form of w. bancrofti from mysore, india provide basis for exploring the periodicity pattern of microfilaria of w. bancrofti prevalent in assam, northeastern region of india. state of ass ... | 2015 | 26418650 |
| seasonal prevalence and blood meal analysis of filarial vector culex quinquefasciatus in coastal areas of digha, west bengal, india. | filariasis is one of the major vector-borne diseases causing serious health problem in the tropics and subtropics. the coastal areas of digha are known to be a filariasis prone region of west bengal, india. the filarial parasite wuchereria bancrofti is transmitted by culex quinquefasciatus, the established filarial vector in west bengal, india. the present work was aimed to determine the abundance of different mosquito species; and the frequency, distribution and blood meal analysis of cx. quinq ... | 2015 | 26418657 |
| role of cysteine-58 and cysteine-95 residues in the thiol di-sulfide oxidoreductase activity of macrophage migration inhibitory factor-2 of wuchereria bancrofti. | macrophage migration inhibitory factor (mif) is the first human cytokine reported and was thought to have a central role in the regulation of inflammatory responses. homologs of this molecule have been reported in bacteria, invertebrates and plants. apart from cytokine activity, it also has two catalytic activities viz., tautomerase and di-sulfide oxidoreductase, which appear to be involved in immunological functions. the cxxc catalytic site is responsible for di-sulfide oxidoreductase activity ... | 2016 | 26432350 |
| efficacy, safety, and pharmacokinetics of coadministered diethylcarbamazine, albendazole, and ivermectin for treatment of bancroftian filariasis. | available treatments for lymphatic filariasis (lf) are limited in their longterm clearance of microfilaria from the blood. the safety and efficacy of a single-dose triple-drug therapy of the antifilarial drugs diethylcarbamazine (dec), ivermectin (ivm), and albendazole (alb) for lf are unknown. | 2016 | 26486704 |
| modelling the distribution and transmission intensity of lymphatic filariasis in sub-saharan africa prior to scaling up interventions: integrated use of geostatistical and mathematical modelling. | lymphatic filariasis (lf) is one of the neglected tropical diseases targeted for global elimination. the ability to interrupt transmission is, partly, influenced by the underlying intensity of transmission and its geographical variation. this information can also help guide the design of targeted surveillance activities. the present study uses a combination of geostatistical and mathematical modelling to predict the prevalence and transmission intensity of lf prior to the implementation of large ... | 2015 | 26496983 |
| more progress in eliminating transmission of onchocerca volvulus and wuchereria bancrofti in the americas: a portent of global eradication. | 2015 | 26503272 | |
| cross-reactivity of filariais ict cards in areas of contrasting endemicity of loa loa and mansonella perstans in cameroon: implications for shrinking of the lymphatic filariasis map in the central african region. | immunochromatographic card test (ict) is a tool to map the distribution of wuchereria bancrofti. in areas highly endemic for loaisis in drc and cameroon, a relationship has been envisaged between high l. loa microfilaria (mf) loads and ict positivity. however, similar associations have not been demonstrated from other areas with contrasting levels of l. loa endemicity. this study investigated the cross-reactivity of ict when mapping lymphatic filariasis (lf) in areas with contrasting endemicity ... | 2015 | 26544042 |
| breast filariasis or inflammatory breast carcinoma? reaching a diagnosis. | lymphatic filariasis is a neglected tropical disease caused by the parasite wuchereria bancrofti. involvement of the breast is relatively uncommon and may affect only 10% of individuals with lymphatic filariasis. we present a case of an elderly woman with breast pathology. the condition clinically appeared as a malignancy. routine diagnostic tests including tissue histopathological studies failed to clinch a diagnosis. however, a serological test helped in identifying the pathology, which turned ... | 2015 | 26567240 |
| impact of insecticide treated mosquito nets and low dose monthly diethylcarbamazine on lymphatic filariasis infection between 1999 and 2004 in two endemic communities of north-eastern tanzania. | lymphatic filariasis (lf) is among the poverty related neglected tropical diseases earmarked for elimination using mass drug administration (mda) strategy. additional use of insecticide treated mosquito nets (itns) might enhance elimination of lf infection. between august 1998 and july 1999, all individuals aged 8 months from magoda and mpapayu villages in north-eastern tanzania, were administered with monthly low dose diethylcarbamazine (dec) at a dosage of 50mg in children aged < 15 years and ... | 2012 | 26591753 |
| filarial hydropneumothorax: a strange journey. | filarial infection can have varied manifestations, but hydropneumothorax at presentation has not yet been reported. a 28-year-old man presented to our hospital with heaviness of the left chest for the past 10 days, which was preceded by a sudden, short stabbing pain in the left chest after straining. chest x-ray revealed left-sided hydropneumothorax. a peripheral blood picture revealed significant eosinophilia. a pleural fluid report also showed eosinophilia and a few motile microfilaria of wuch ... | 2015 | 26604240 |
| cytological diagnosis of bancroftian filariasis presented as a subcutaneous swelling in the cubital fossa: an unusual presentation. | filariasis is a disabling parasitic disease and the prevalence of lymphatic filariasis caused by wuchereria bancrofti is quite high in india. however, w. bancrofti presenting as a subcutaneous swelling and a demonstration of microfilariae in cytological smears from upper extremity lesions is extremely rare. we report a case of 20-year-old male who presented with a small subcutaneous swelling near medial aspect of the left cubital fossa. the wet mount preparation showed many motile microfilariae. ... | 2015 | 26634138 |
| enhanced efficacy of sequential administration of albendazole for the clearance of wuchereria bancrofti infection: double blind rct. | till today, there is no effective treatment protocol for the complete clearance of wuchereria bancrofti (w.b) infection that causes secondary lymphoedema. in a double blind randomized control trial (rct), 146 asymptomatic w. b infected individuals were randomly assigned to one of the four regimens for 12 days, dec 300 mg + doxycycline 100 mg coadministration or dec 300 mg + albendazole 400 mg co-administration or dec 300 mg + albendazole 400 mg sequential administration or control regimen dec 30 ... | 2015 | 26691247 |
| wuchereria bancrofti infection in rural tropical guinea savannah communities: rapid epidemiological assessment using immunochromatographic card test and prevalence of hydrocoele. | lymphatic filariasis (lf) caused by the nematode wuchereria bancrofti is a major public health concern in endemic communities worldwide. among tropical diseases it is second to malaria in terms of disability adjusted life years. the nigerian lf elimination programme has been slated for 2015. currently, there is paucity of published data on the problem in rural ebonyi state. this survey was conducted in six rural communities of southwestern ebonyi state to assess its prevalence among the populati ... | 2015 | 26691265 |
| construction and bacterial expression of a recombinant single-chain antibody fragment against wuchereria bancrofti sxp-1 antigen for the diagnosis of lymphatic filariasis. | global programmes to eliminate lymphatic filariasis (gpelf) require mapping, monitoring and evaluation using filarial antigen diagnostic kits. to meet this objective, a functional single-chain fragment variable (scfv) specific for filarial wuchereria bancrofti sxp-1 (wb-sxp-1) antigen was constructed for the diagnosis of active filarial infection, an alternative to the production of complete antibodies using hybridomas. the variable heavy chain (vh) and the variable light chain (kappa) (vκ) gene ... | 2016 | 26693887 |
| loss of sensitivity of immunochromatographic test (ict) for lymphatic filariasis diagnosis in low prevalence settings: consequence in the monitoring and evaluation procedures. | diagnostic tools for lymphatic filariasis (lf) elimination programs are useful in mapping the distribution of the disease, delineating areas where mass drug administrations (mda) are required, and determining when to stop mda. the prevalence and burden of lf have been drastically reduced following mass treatments, and the evaluation of the performance of circulating filarial antigen (cfa)-based assays was acknowledged to be of high interest in areas with low residual lf endemicity rates after mu ... | 2015 | 26700472 |
| microfilaria of wuchereria bancrofti in plasma cell myeloma: a case report. | 2015 | 26714518 | |
| patency of litomosoides sigmodontis infection depends on toll-like receptor 4 whereas toll-like receptor 2 signalling influences filarial-specific cd4(+) t-cell responses. | balb/c mice develop a patent state [release of microfilariae (mf), the transmission life-stage, into the periphery] when exposed to the rodent filariae litomosoides sigmodontis. interestingly, only a portion of the infected mice become patent, which reflects the situation in human individuals infected with wuchereria bancrofti. since those individuals had differing filarial-specific profiles, this study compared differences in immune responses between mf(+) and mf(-) infected balb/c mice. we dem ... | 2016 | 26714796 |
| is there a risk of filarial infection during long-term missions in haiti? | haiti has the highest prevalence of lymphatic filariasis (wuchereria bancrofti) in the western hemisphere. still, the risk of filarial infection for long-term visitors such as humanitarian aid workers or military personnel is uncertain. the presented study analyzed the exposure to w. bancrofti in chilean participants of the un stabilization mission in haiti (minustah) in 2011. | 2017 | 26750186 |
| in search of a potential diagnostic tool for molecular characterization of lymphatic filariasis. | lymphatic filariasis (lf) is a chronic disease and is caused by the parasites wuchereria bancrofti (w. bancrofti), brugia malayi (b. malayi) and brugia timori (b. timori). in the present study, setaria cervi (s. cervi), a bovine filarial parasite has been used. previously, it has been reported that the s. cervi shares some common proteins and antigenic determinants with that of human filarial parasite. the larval stages of filarial species usually cannot be identified by classical morphology. he ... | 2016 | 26751881 |
| ecological drivers of mansonella perstans infection in uganda and patterns of co-endemicity with lymphatic filariasis and malaria. | mansonella perstans is a widespread, but relatively unknown human filarial parasite transmitted by culicoides biting midges. although it is found in many parts of sub-saharan africa, only few studies have been carried out to deepen the understanding of its ecology, epidemiology, and health consequences. hence, knowledge about ecological drivers of the vector and parasite distribution, integral to develop spatially explicit models for disease prevention, control, and elimination strategies, is li ... | 2016 | 26793972 |
| yeast-based high-throughput screens to identify novel compounds active against brugia malayi. | lymphatic filariasis is caused by the parasitic worms wuchereria bancrofti, brugia malayi or b. timori, which are transmitted via the bites from infected mosquitoes. once in the human body, the parasites develop into adult worms in the lymphatic vessels, causing severe damage and swelling of the affected tissues. according to the world health organization, over 1.2 billion people in 58 countries are at risk of contracting lymphatic filariasis. very few drugs are available to treat patients infec ... | 2016 | 26812604 |
| prospects, drawbacks and future needs of xenomonitoring for the endpoint evaluation of lymphatic filariasis elimination programs in africa. | lymphatic filariasis (lf) is a debilitating disease caused by wuchereria bancrofti, brugia malayi and b. timori parasitic worms and transmitted by culex, anopheles, aedes and mansonia mosquitoes. mass drug administration (mda) to reduce the infection levels in the human population is the key component of lf elimination programs. however, the potential of the use of vector control is gaining recognition as a tool that can complement mda. the method of monitoring the parasites in mosquito vectors ... | 2016 | 26822601 |
| population genomics of the filarial nematode parasite wuchereria bancrofti from mosquitoes. | wuchereria bancrofti is a parasitic nematode and the primary cause of lymphatic filariasis--a disease specific to humans. w. bancrofti currently infects over 90 million people throughout the tropics and has been acknowledged by the world health organization as a vulnerable parasite. current research has focused primarily on the clinical manifestations of disease and little is known about the evolutionary history of w. bancrofti. to improve upon knowledge of the evolutionary history of w. bancrof ... | 2016 | 26850696 |
| robotic surgery for treatment of chyluria. | chyle is a milky lymphatic fluid that is normally formed in the small intestine to aid in the absorption of dietary fats. occasionally, chyle leaks into the kidney, ureter, or bladder, which results in chyluria. chyluria is most commonly caused by the parasite wuchereria bancrofti and is therefore extremely rare in the usa. the use of robotic surgery for treatment has been suggested as a viable option, but has not been thoroughly reported in the literature. this article reviews the literature on ... | 2016 | 26861449 |
| an unusual presentation of filariasis in a nonendemic country. | filariasis is an endemic disease with worldwide distribution in tropical and subtropical regions. it is uncommon in qatar. the conventional diagnostic procedure is the demonstration of microfilaria in blood smears. even with its high incidence, it is unusual to detect microfilaria in fine needle aspiration cytology (fnac) smears. although the 'filarial dance sign' is rarely documented, it remains a classical ultrasonographic sign in lymphatic filariasis. | 2015 | 26865993 |
| presence of wuchereria bancrofti microfilaremia despite 7 years of annual ivermectin monotherapy mass drug administration for onchocerciasis control: a study in north-west ethiopia. | there is considerable interest in determining whether mass drug administration (mda) with ivermectin for onchocerciasis control will eliminate coendemic lymphatic filariasis (lf). the objective of this study was to determine the prevalence of lf microfilaremia in onchocerciasis endemic districts that had received 7 years of mda with ivermectin. | 0 | 26878935 |
| identification and validation of loa loa microfilaria-specific biomarkers: a rational design approach using proteomics and novel immunoassays. | immunoassays are currently needed to quantify loa loa microfilariae (mf). to address this need, we have conducted proteomic and bioinformatic analyses of proteins present in the urine of a loa mf-infected patient and used this information to identify putative biomarkers produced by l. loa mf. in total, 70 of the 15,444 described putative l. loa proteins were identified. of these 70, 18 were l. loa mf specific, and 2 of these 18 (loag_16297 and loag_17808) were biologically immunogenic. we develo ... | 2016 | 26884435 |
| differential evolutionary selection and natural evolvability observed in alt proteins of human filarial parasites. | the abundant larval transcript (alt-2) protein is present in all members of the filarioidea, and has been reported as a potential candidate antigen for a subunit vaccine against lymphatic filariasis. to assess the potential for vaccine escape or heterologous protection, we examined the evolutionary selection acting on alt-2. the ratios of nonsynonymous (k(a)) to synonymous (k(s)) mutation frequencies (ω) were calculated for the alt-2 genes of the lymphatic filariasis agents brugia malayi and wuc ... | 2016 | 26890364 |
| historic accounts of mansonella parasitaemias in the south pacific and their relevance to lymphatic filariasis elimination efforts today. | there are two species of filarial parasites with sheathless microfilariae known to commonly cause parasitaemias in humans: mansonella perstans and mansonella ozzardi. in most contemporary accounts of the distribution of these parasites, neither is usually considered to occur anywhere in the eastern hemisphere. however, sir patrick manson, who first described both parasite species, recorded the existence of sheathless sharp-tailed mansonella ozzardi-like parasites occurring in the blood of native ... | 2016 | 26972389 |
| molecular xenomonitoring of wuchereria bancrofti in culex quinquefasciatus from an endemic area: comparison of two dna extraction methods for realtime pcr assay. | 2016 | 27004582 | |
| pyrosequencing using sl and 5s rrna as molecular markers for identifying zoonotic filarial nematodes in blood samples and mosquitoes. | lymphatic filariasis is principally caused by wuchereria bancrofti, and brugia malayi. the other two filarial nematode species, brugia pahangi and dirofilaria immitis, possibly cause human zoonotic diseases. | 2016 | 27008279 |
| unusual presentation of filariasis as an abscess: a case report. | bancroftian filariasis, a tropical and subtropical disease caused by wuchereria bancrofti, is transmitted by the culex mosquito. the disease is conventionally diagnosed by the demonstration of microfilaria in peripheral blood smear. microfilaria and adult filarial worms have been incidentally detected in fine needle aspiration cytology (fnac) in various locations. the disease may be missed if one is not aware of the possibility, particularly in cases where eosinophilia is absent. therefore, clin ... | 2017 | 27011444 |
| c-cinnamoyl glycosides as a new class of anti-filarial agents. | a series of c-cinnamoyl glycosides has been synthesized in good yield by the bf3·oet2 catalyzed aldol condensation of c-glycosylated acetone derivative with a variety of aromatic aldehydes. the synthesized compounds were evaluated for their potential as anti-filarial agents against bovine filarial parasite setaria cervi and human filariid wuchereria bancrofti using a number of biological assays such as relative movability (rm) assessment and mtt reduction assay. among twenty seven test compounds ... | 2016 | 27015610 |
| insights into the structure-function relationship of brugia malayi thymidylate kinase (bmtmk). | lymphatic filariasis is a debilitating disease caused by lymph dwelling nematodal parasites like wuchereria bancrofti, brugia malayi and brugia timori. thymidylate kinase of b. malayi is a key enzyme in the de novo and salvage pathways for thymidine 5'-triphosphate (dttp) synthesis. therefore, b. malayi thymidylate kinase (bmtmk) is an essential enzyme for dna biosynthesis and an important drug target to rein in filariasis. in the present study, the structural and functional changes associated w ... | 2016 | 27044348 |
| molecular epidemiology of blood-borne human parasites in a loa loa-, mansonella perstans-, and plasmodium falciparum-endemic region of cameroon. | the study of the interactions among parasites within their hosts is crucial to the understanding of epidemiology of disease and for the design of effective control strategies. we have conducted an assessment of infections with loa loa, mansonella perstans, wuchereria bancrofti, and plasmodium falciparum in eastern cameroon using a highly sensitive and specific quantitative polymerase chain reaction assay using archived dried whole blood spots. the resident population (n = 1,085) was parasitized ... | 2016 | 27044568 |
| prevalence of lymphatic filariasis and treatment effectiveness of albendazole/ ivermectin in individuals with hiv co-infection in southwest-tanzania. | annual mass treatment with ivermectin and albendazole is used to treat lymphatic filariasis in many african countries, including tanzania. in areas where both diseases occur, it is unclear whether hiv co-infection reduces treatment success. | 2016 | 27070786 |
| glucose and glycogen metabolism in brugia malayi is associated with wolbachia symbiont fitness. | wolbachia are endosymbiotic bacteria found in the majority of arthropods and filarial nematodes of medical and veterinary importance. they have evolved a wide range of symbiotic associations. in filarial nematodes that cause human lymphatic filariasis (wuchereria bancrofti, brugia malayi) or onchocerciasis (onchocerca volvulus), wolbachia are important for parasite development, reproduction and survival. the symbiotic bacteria rely in part on nutrients and energy sources provided by the host. ge ... | 2016 | 27078260 |
| detection and quantification of wuchereria bancrofti and brugia malayi dna in blood samples and mosquitoes using duplex droplet digital polymerase chain reaction. | lymphatic filariasis, a mosquito-borne disease, is still a major public health problem in tropical and sub-tropical countries. effective diagnostic tools are required for identification of infected individuals, for epidemiological assessment, and for monitoring of control programs. a duplex droplet digital polymerase chain reaction (ddpcr) was conducted to differentiate and quantify wuchereria bancrofti dna by targeting the long dna repeat (ldr) element and brugia malayi dna by targeting the hha ... | 2016 | 27085707 |
| measurement of circulating filarial antigen levels in human blood with a point-of-care test strip and a portable spectrodensitometer. | the alere filariasis test strip (fts) is a qualitative, point-of-care diagnostic tool that detects wuchereria bancrofti circulating filarial antigen (cfa) in human blood, serum, or plasma. the global program to eliminate lymphatic filariasis employs the fts for mapping filariasis-endemic areas and assessing the success of elimination efforts. the objective of this study was to explore the relationship between the intensity of positive test lines obtained by fts with cfa levels as determined by e ... | 2016 | 27114288 |
| an alternative strategy to generate coding sequence of macrophage migration inhibitory factor-2 of wuchereria bancrofti. | different developmental stages of wuchereria bancrofti, the major causal organism of lymphatic filariasis (lf), are difficult to obtain. beside this limitation, to obtain complete coding sequence (cds) of a gene one has to isolate mrna and perform subsequent cdna synthesis which is laborious and not successful at times. in this study, an alternative strategy employing polymerase chain reaction (pcr) was optimized and validated, to generate cds of macrophage migration inhibitory factor-2 (wbmif-2 ... | 2016 | 27121522 |
| "filarial dance sign" real-time ultrasound diagnosis of filarial oophoritis. | filariasis is a parasitic disease caused by filarial nematodes (wuchereria bancrofti, brugia malayi, and brugia timori) that commonly causes lymphatic obstruction resulting in edema and increase in the size of the affected organ. filariasis is diagnosed by identifying microfilariae on giemsa stain. the immunochromatographic card test is diagnostic. ultrasound is the imaging modality of choice for detecting adult filarial worms/microfilaria in the lymphatic system, which are responsible for the c ... | 2016 | 27130361 |
| integration of multiplex bead assays for parasitic diseases into a national, population-based serosurvey of women 15-39 years of age in cambodia. | collection of surveillance data is essential for monitoring and evaluation of public health programs. integrated collection of household-based health data, now routinely carried out in many countries through demographic health surveys and multiple indicator surveys, provides critical measures of progress in health delivery. in contrast, biomarker surveys typically focus on single or related measures of malaria infection, hiv status, vaccination coverage, or immunity status for vaccine-preventabl ... | 2016 | 27136913 |
| microfilariae in a bone marrow aspirate. | filariasis is a common cause of morbidity in certain parts of india, especially in the coastal districts. repeated episodes of fever with chills and rigor, lymphadenopathy are the initial manifestations which gradually progress to elephantiasis. wuchereria bancrofti is the most common parasite causing lymphatic filariasis in india. detecting microfilaria in peripheral blood with or without diethylcarbamazine citrate provocation is the common diagnostic modality in suspected cases. however microf ... | 2016 | 27142269 |
| further evidence of the cross-reactivity of the binax now® filariasis ict cards to non-wuchereria bancrofti filariae: experimental studies with loa loa and onchocerca ochengi. | the immunochromatographic test (ict) for lymphatic filariasis is a serological test designed for unequivocal detection of circulating wuchereria bancrofti antigen. it was validated and promoted by who as the primary diagnostic tool for mapping and impact monitoring for disease elimination following interventions. the initial tests for specificity and sensitivity were based on samples collected in areas free of loiasis and the results suggested a near 100% specificity for w. bancrofti. the possib ... | 2016 | 27151313 |
| ocular filariasis in us residents, returning travelers, and expatriates. | several factors acting in concert now place us residents, returning travelers, and expatriates at risks of contracting ocular filariasis including increasing seroprevalence rates of zoonotic filariasis, international travel bringing tourists to and expatriates from filariasis-endemic regions, and warming temperatures extending distribution ranges of arthropod vectors. to describe the epidemiology and outcomes of ocular filariasis and to recommend strategies for the diagnosis, management, and pre ... | 2016 | 27159510 |
| assessing drivers of the igg4 antibody reactivity to recombinant antigen bm14 in wuchereria bancrofti endemic populations in east africa. | a high proportion of the human population in lymphatic filariasis (lf) endemic areas is positive for filarial specific igg4 antibodies, including many individuals without microfilariae (mf; circulating larvae in the human blood) or circulating filarial antigens (cfa; marker of adult worm infection). the antibodies are commonly regarded as markers of infection and/or exposure to filarial larvae, but a direct association between the antibodies and these indices has not been well documented. the pr ... | 2016 | 27172877 |
| rhizome extracts of curcuma zedoaria rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite setaria digitata in vitro. | human lymphatic filariasis (lf) is mainly caused by filarial parasite wuchereria bancrofti and is the second leading cause of long term and permanent disability in tropical countries. to date, incapability to eliminate long lived adult parasites by current drugs remains the major challenge in the elimination of lf. hence, in the current study, the efficacy of rhizome extracts of curcuma zedoaria (a plant traditionally used in sri lanka in the management of lf) was evaluated as an effective filar ... | 2016 | 27174667 |
| microfilarial involvement of the neck region: a case report and review of literature. | filariasis is caused by parasitic infections, most commonly brugia malayi and wuchereria bancrofti. india is one of the endemic countries for such disease. the usually involved organs are lower limbs and external genitalia. neck region is rarely involved and only a few cases have been reported in literature. | 2017 | 27182151 |
| microfilariae, a common parasite in an unusual site: a case report with literature review. | filariasis is common in tropical countries. wuchereria bancrofti is the most common parasite which causes lymphatic filariasis in india. this paper reports the finding of microfilariae in cervicovaginal smear of a 61-year-old post menopausal woman with a brief review of literature. there are limited numbers of reports describing the presence of microfilariae in the cervicovaginal smears and even rarely as an incidental finding. it is very important to keep in mind and screen for microfilariae in ... | 2016 | 27190816 |
| programmatic use of molecular xenomonitoring at the level of evaluation units to assess persistence of lymphatic filariasis in sri lanka. | sri lanka's anti filariasis campaign distributed 5 rounds of mass drug administration (mda with dec plus albendazole) to all endemic regions in the country from 2002-2006. post-mda surveillance results have generally been encouraging. however, recent studies have documented low level persistence of wuchereria bancrofti in galle district based on comprehensive surveys that include molecular xenomonitoring (mx, detection of filarial dna in mosquitoes) results. the purposes of this study were to de ... | 2016 | 27196431 |
| risk factors for epilepsy in bas-uélé province, democratic republic of the congo: a case-control study. | the reason for the high prevalence of epilepsy in onchocerciasis endemic areas remains unknown. the aim of this study was to detect risk factors associated with epilepsy in a region endemic for onchocerciasis. | 2016 | 27210267 |
| familial aggregation and heritability of wuchereria bancrofti infection. | the familial recurrence risk of lymphatic filariasis (lf) is unknown. this case study aimed to evaluate the familial susceptibility to infection with wuchereria bancrofti and to microfilaremia in a village of the republic of congo. | 2016 | 27230098 |
| antifilarial activity of diterpenoids from taxodium distichum. | lymphatic filariasis caused by wuchereria bancrofti, brugia malayi and b. timori, is a debilitating disease with an adverse social and economic impact. the infection remains unabated in spite of treatment with existing antifilarial drugs diethylcarbamazine (dec) and ivermectin which are chiefly microfilaricides. there is therefore, need for macrofilaricides, embryostatic agents and better microfilaricides. in the present study we explored the antifilarial potential of crude extract and its molec ... | 2016 | 27245322 |
| a rare case of ovarian filariasis in abidjan. | ovarian filariasis is an exceptional disease and displays a major diagnostic problem even in endemic areas. we reported the case of a 19-year-old patient who had ovarian cyst which was revealed by chronic pelvic pain. the histological examination of oophorectomy specimen led to the wuchereria bancrofti filariasis of the ovary. the anatomopathologic examination is required for the diagnosis of this disease. | 2016 | 27313932 |
| mosquito identification and molecular xenomonitoring of lymphatic filariasis in selected endemic areas in giza and qualioubiya governorates, egypt. | lymphatic filariasis is a vector-borne health problem that has been focally endemic in egypt for centuries. the chief vectors of transmission are culicinae species. control measures in the form of mass drug administration of dec citrate treatment have been implemented in nile delta for almost a decade. this study aimed to identify the prevalent mosquito species in endemic areas in giza and qualioubiya governorates and to monitor wuchereria bancrofti infection by detecting the parasite dna in col ... | 2016 | 27363044 |
| periocular filarial lymphoedema. | 2006 | 27407858 | |
| mapping is a prerequisite for elimination of filariasis and effective targeting of filarial 'hot spots'. | this study was undertaken to determine the prevalence of filarial infection in the districts of madhya pradesh, which were classified as non-endemic by the national program for control of filariasis. these districts showed evidence of clinical symptoms related to filariasis. to confirm the presence of filariasis, night blood surveys and entomological surveys were carried out to detect microfilaria in humans and filarial infection in vectors. | 2017 | 27413817 |
| finding wolbachia in filarial larvae and culicidae mosquitoes in upper egypt governorate. | wolbachia is an obligatory intracellular endosymbiotic bacterium, present in over 20% of all insects altering insect reproductive capabilities and in a wide range of filarial worms which is essential for worm survival and reproduction. in egypt, no available data were found about wolbachia searching for it in either mosquitoes or filarial worms. thus, we aimed to identify the possible concurrent presence of wolbachia within different mosquitoes and filarial parasites, in assiut governorate, egyp ... | 2016 | 27417080 |
| burden of lymphatic filariasis morbidity in an area of low endemicity in brazil. | the global programme to eliminate lymphatic filariasis has two main components: interrupting transmission of lymphatic filariasis (lf) and managing morbidity and preventing disability. however, interventions to prevent and manage lf-related disabilities in endemic communities have been of limited extent. the aim of this study was to describe the prevalence of morbidity and its correlation with filarial infection, thereby filling a gap that existed regarding the data on morbidity in brazil. prese ... | 2016 | 27427218 |
| the mitochondrial genomes of culex tritaeniorhynchus and culex pipiens pallens (diptera: culicidae) and comparison analysis with two other culex species. | culex tritaeniorhynchus and culex pipiens pallens are the major vectors of the japanese encephalitis virus and wuchereria bancrofti, the causative agent of filariasis. the knowledge of mitochondrial genomes has been widely useful for the studies on molecular evolution, phylogenetics and population genetics. | 2016 | 27444629 |
| effect of wuchereria bancrofti infection on hiv incidence in southwest tanzania: a prospective cohort study. | the past decades have seen an ongoing controversial debate about whether the immune activation induced by helminths has an effect on the susceptibility of individuals to hiv. in view of this, we assessed the effect of lymphatic filariasis, a chronic helminth disease elicited by wuchereria bancrofti, on hiv incidence in southwest tanzania. | 2016 | 27495354 |
| filarial orchitis due to wuchereria bancrofti masquerading as testicular neoplasm. | 2016 | 27582521 | |
| immunization with wuchereria bancrofti glutathione-s-transferase elicits a mixed th1/th2 type of protective immune response against filarial infection in mastomys. | lymphatic filariasis is a mosquito borne parasitic infection and can severely affect the normal working ability of an individual. currently there is no vaccine available to prevent this infection and the development of a potential vaccine could effectively support the on-going mass drug administration program by world health organization (who). filarial parasites have complex mechanisms to modulate the host immune responses against them. the glutathione-s-transferases (gst) are the important enz ... | 2016 | 27605739 |
| mathematical modelling of lymphatic filariasis elimination programmes in india: required duration of mass drug administration and post-treatment level of infection indicators. | india has made great progress towards the elimination of lymphatic filariasis. by 2015, most endemic districts had completed at least five annual rounds of mass drug administration (mda). the next challenge is to determine when mda can be stopped. we performed a simulation study with the individual-based model lymfasim to help clarify this. | 2016 | 27624157 |
| wuchereria bancrofti: unusual presentation as pancytopenia. | wuchereria bancrofti is an endemic filarial nematode spread by a mosquito vector. the clinical manifestations vary from asymptomatic microfilaremeia to lymhoedema. we report two cases of microfilaria of wuchereria bancrofti in bone marrow presenting as peripheral pancytopenia. the patient did not have any classical features of lymphoedema or elephantiasis. the diagnostic demonstration of microfilaria with unusual presentations has been done in cytology specimens from various sites. microfilaria ... | 2016 | 27630856 |
| therapeutic potential of the immunomodulatory proteins wuchereria bancrofti l2 and brugia malayi abundant larval transcript 2 against streptozotocin-induced type 1 diabetes in mice. | epidemiological and experimental evidence has supported the concept of using helminths as alternative bio-therapeutic agents in the treatment of type 1 diabetes (t1d). in the current study, two filarial proteins, recombinant wuchereria bancrofti l2 (rwbl2) and brugia malayi abundant larval transcript 2 (rbmalt-2) have been investigated, individually and in combination, for their therapeutic potential in streptozotocin (stz)-induced t1d. the rwbl2 and rbmalt-2 proteins, when administered individu ... | 2016 | 27667321 |