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similarity principles and intrinsic geometries: contrasting approaches to interspecies scaling.we criticize standard allometric approaches on the grounds that they emphasize scaling to one variable at a time, whereas chemically reactive hydrodynamic systems involved in pharmacokinetic phenomena are of higher dimension. we show that attempts based on mechanical similitude to set a dosage that would be equivalent across species (for example, from mouse to humans) lead to ambiguous results. another failing of standard allometry may be its incapability to accommodate the neoteny of homo sapie ...19863820095
[successful delivery in a female with thrombotic thrombocytopenic purpura]. 20133820614
defective biosynthesis of proteolipid protein in pelizaeus-merzbacher disease.the brain of an 18-year-old patient with pelizaeus-merzbacher disease was examined by standard neuropathological and biochemical methods and by immunocytochemical and immunochemical techniques. analysis revealed a lack of myelin-specific lipids, but showed a residual immunoreactivity for myelin basic protein, myelin-associated glycoprotein, and 2',3'-cyclic nucleotide-3'-phosphodiesterase. examination by immunocytochemistry and enzyme-linked immunosorbent assay showed an absence of proteolipid a ...19873827224
[can beta-receptor blockers trigger coronary spasm?].beta-blockers are frequently administered in therapy of arterial hypertension and coronary heart disease. they mostly lead to an asymptomatic increase of peripheral and coronary resistance. three patients in whom there were indications of a deterioration of myocardial blood flow under beta-blockade were observed within a few weeks. after discontinuation of the beta-blockers and instituting a therapy with calcium antagonists, both a reduction of ischemia in the exercise ecg and a reduction of sym ...20133829948
[an experimental study on adhesion blocking in simultaneous injury of tendon and nerve].the formation of adhesions between simultaneously injured tendon and nerve with and without adhesion blocking materials was studied by using a rabbit model. a collagen membrane, produced from adult bovine corium and with a negative electric charge induced by chemical modification, was used as the blocking material. microangiography and histological studies were performed to investigate the vascular supply to the adhesions. the following results were obtained. blood vessel proliferation was obser ...19853831164
animal model for theophylline--cimetidine drug interaction.cimetidine (300 mg i.v.) and theophylline (15 mg/kg i.v.) were studied in beagle dogs for possible drug interaction. the drugs were administered alone and in combination using a crossover design. although none of the determined pharmacokinetic parameters for theophylline changed significantly in the presence of cimetidine, a trend towards significance was found for the terminal half-life, area under the curve, and mean residence time. the magnitude in changes found in beagles is representative o ...19853831635
probabilistic sensitivity analysis using monte carlo simulation. a practical approach.the data for medical decision analyses are often unreliable. traditional sensitivity analysis--varying one or more probability or utility estimates from baseline values to see if the optimal strategy changes--is cumbersome if more than two values are allowed to vary concurrently. this paper describes a practical method for probabilistic sensitivity analysis, in which uncertainties in all values are considered simultaneously. the uncertainty in each probability and utility is assumed to possess a ...20133831638
[crohn disease as prothrombotic state. application of new methods for the verification of hemostatic changes]. 20133832201
a strain of urease-producing vibrio parahaemolyticus isolated in malaysia. 19853833915
a further contribution to the study of the genus penicillium.a study of one hundred penicillium strains belonging to raper and thom's monoverticillate series was carried out. the data compiled led to the conclusion that there are no significant biochemical differences which would make possible an accurate separation of the strains belonging to the series.20133834278
morphologic and histochemical studies of bone cells from sl-3 rats. 19853834472
[effect of titanium phosphate, zirconium oxide and a mixture of ammonium phosphotungstenate with zirconium phosphate on the elimination of radioactive cesium from the bodies of rats]. 19853835674
[treatment of echinococcosis (e. granulosus) with albendazole].albendazole, given as a 28 day course of 800 mg/day at 15 days intervals can be effective in the treatment of liver and lung hydatic cysts in adults of average weight. on average, six courses are required to obtain a satisfactory result (negative serological results, decrease in volume of scanner images). the treatment must be monitored and should only be prescribed in case of surgical contraindication or refusal by the patient to undergo surgery.20133836758
risk of arterial hypertension and characteristics of functional brain asymmetry in workers airlifted for short tours of duty. 20133837741
plasma cell leukemia accompanied by polyclonal gammopathy and congenital tumor in the atrioventricular node.a 32-year-old man with plasma cell leukemia and congenital tumor of the atrioventricular node is described. although m protein could not be detected by immunoelectrophoresis, the examination of bone marrow atypical plasma cells with immunofluorescent and immunoperoxidase showed that most of these plasma cells produced igg or iga. also some plasma cells possessed concomitantly both igg and iga. an electrocardiogram revealed complete atrioventricular block. the patient died of aspergillosis and bl ...19853837948
degenerative lesions of a coronary chemoreceptor and nearby neural elements in the hearts of victims of sudden death.a coronary chemoreceptor and its neighboring nerves and ganglia were studied by serial sections of tissue taken from the hearts of sixteen victims of sudden unexpected death. either focal or extensive inflammatory destruction was present in the chemoreceptors of 13 of the 16 hearts, and similar abnormalities of local nerves and ganglia were present in all 16 hearts. since an identical coronary chemoreceptor in the dog has previously been shown to be the site of origin of a powerful reflex with m ...19863837961
isolation and characterization of neuropeptide y from porcine intestine.the isolation and primary structure of intestinal neuropeptide y (npy) is described. the peptide was purified from porcine intestinal extracts using a chemical assay and radioimmunoassay for npy. the amino acid sequence of this peptide is: tyr-pro-ser-lys-pro-asp-asn-pro-gly-glu-asp-ala-pro-ala-glu-asp-leu-ala- arg-tyr-tyr- ser-ala-leu-arg-his-tyr-ile-asn-leu-ile-thr-arg-gln-arg-tyr-nh2. this the structure of intestinal npy is identical to the npy of brain origin.19853838090
[experiences with patis, the patient information system]. 20133840304
[preliminary clinical observations on the eutrophic-protective action on the corneal epithelium of combined vitamin a + e].the epithelio-protective activity of a combination of retinol and tocopherol has been studied. the two vitamins have been administered orally to a group of patients suffering from different corneal diseases. a control group was treated with a placebo associated to the usual topical therapies. with some reserve, the evaluation of the vitamin therapy is positive as the epithelial repairing was more rapid in the vitamin treated group, but the poor homogeneity of the corneal diseases permits a quali ...20133842230
ophthalmological complications of cryptococcal meningitis.two patients with cryptococcal meningitis associated with ophthalmological complications are described. one patient developed a cryptococcal fundal lesion which disappeared during chemotherapy. chronically raised intracranial pressure was associated with a visual field defect. this resolved with repeated lumbar punctures. the second patient developed visual deficits secondary to papilloedema and responded to optic nerve decompression. in both cases ct scanning demonstrated swelling of the optic ...20133843225
computer system support. part ii. 20133846051
[a comparative study. the older person too is an individual]. 20133850215
aggression against nurses. 20133852671
theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: xiv. mutational and non-mutational mechanisms as subsets of a more general mechanism. part c. a defined cancer mutation.the results of applying a mechanism of ethionine-induced embryonic gene derepressions to explain similar features found in hereditary tyrosinemia have been extended to a well defined cancer mutation. in all three cases, the described mechanism is compatible with the explanation for the etiology of embryonic like phenotypic expressions in cells and potentially for the carcinogenic process. the essence of the formulated process for a human bladder carcinoma mutation in the ras gene for a protein p ...19853853079
[caries and candidiasis in the deciduous dentition]. 20133857813
[hla antigens in the etiopathogenesis of pemphigus]. 20133858260
generation of prostaglandin e2-like radioimmunoreactive material in human plasma during storage at -20 c but not at -80 c.concentrations of prostaglandin e2 (pge2) as determined by radioimmunoassay following silicic-acid column chromatography in extracted samples (n = 5) of human plasma (na2edta: 18 mg/5 ml blood; indomethacin: 1mg/5 ml blood) were less than 1.0 pg/ml when the samples were extracted immediately after blood withdrawal. virtually identical concentrations of pge2 were determined in samples stored at -80 degrees c for up to 6 months. however, when the same analytical procedures were used after prolonge ...19853858888
base-varnish interactions around amalgam restorations: spectrophotometric and microscopic assessment of leakage. 20123862381
the temporomandibular joint from the viewpoint of the anatomist. 20133862765
relation between nasal/voice accelerometric values and interval estimates of hypernasality.nasal/throat accelerometric ratios were obtained from 12 hypernasal and three normal children. the accelerometric voltages comprising the ratio were analogs of nasal and anterior-neck tissue vibrations. audio recordings, which were obtained simultaneously with the accelerometric voltages, were later judged for hypernasality using an equal-appearing-interval (eai) scale. high correlations were evident between accelerometric and eai values when a stimulus sentence contained obstruents, semivowels, ...20133863721
a method to teach tooth carving: the template technique. 20133865332
protein loss of bovine dental enamel during in-vitro subsurface demineralization.a chemical system based on the dialysis principle was used to study protein loss of dental enamel during demineralization with an acetic-acid buffer solution containing calcium and phosphate, in which the fluoride-ion activity was kept constant. this resulted in a subsurface lesion, with a depth of about 130 microns. after demineralization, protein material was isolated from the demineralization solution. u.v. spectra of the protein showed strong absorbance between 240 and 300 nm. amino-acid com ...19853865639
in vitro activity of ci-934, a quinolone carboxylic acid active against gram-positive and -negative bacteria.ci-934 is a totally synthetic difluorinated quinolinecarboxylic acid with an ethyl-amino-methyl pyrrolidine side chain, which has broad-spectrum antibacterial activity, including particular potency directed against streptococci and staphylococci. the ci-934 mic (micrograms per milliliter) for 90% of the strains tested was 0.4 (range, 0.2 to 0.8) for a group of streptococci (pneumococci, viridans streptococci, streptococcus faecalis, and lancefield groups a, b, and c), 0.2 (0.05 to 0.2) for staph ...19853866513
think about your pension! 20133866716
[real possibilities in surgical dental preservation]. 20123866739
vibrio parahaemolyticus osteomyelitis of 12 years' duration. 19853868797
radiology notes. case 1. eosinophilic granuloma of the spine. 20133871906
gas chromatographic determination of mefloquine in human and dog plasma using electron-capture detection.a sensitive and selective gas-liquid chromatographic method for the determination of plasma levels of mefloquine in human and dog plasma is described. the drug and internal standard were extracted from plasma at ph 9.0 into isopropyl acetate. after evaporation of the solvent, the residue was taken up in toluene and derivatised with heptafluorobutyrylimidazole. the derivative was quantified by gas-liquid chromatography on a 3% gc ge-se30 column with electron-capture detection. the limit of detect ...19853872308
the effect of induced electric currents on bone after experimental osteotomy in sheep.we have investigated the effect of currents induced by electromagnetic fields on the healing of the tibia of sheep after osteotomy, using objective and quantifiable criteria wherever possible. a battery-powered, induction apparatus was developed and was enclosed within the cast applied to the limb, so that the treated fractures received pulsed magnetic fields for 24 hours a day while the animals were freely mobile. in all, 13 sheep were treated and 13 were used as controls. the response was asse ...19853873459
contrasting mandibular growth and facial development in long face syndrome, juvenile rheumatoid polyarthritis, and mandibulofacial dysostosis.the complex rotation process of the mandible during growth is elucidated by longitudinal roentgencephalometric analyses, using metallic implants as fixed references. contrasting development of face and mandibular shape is described in three subjects. in the so-called long face syndrome, development is characterized by increasing inclination of the mandible during growth with only moderate remodeling. in the subjects with juvenile rheumatoid polyarthritis and mandibulofacial dysostosis, the incre ...20133877091
alcohol-related symptoms. 20133877581
interleukin 1 released from beagle alveolar macrophages exposed to dust particles. 19853877837
interleukin 1 released from beagle alveolar macrophages exposed to dust particles. 19853877837
[use of thymalin in the complex treatment of infantile cerebral palsy].the immunomodulator thymalin was included in the complex of rehabilitative therapy of 22 children with cerebral paralysis expressed in the form of spastic diplegia and with frequent intercurrent infections. immunological parameters were measured before and after treatment to determine the efficiency of the therapy. improvement in the neurological defect was observed in 54.55% of children with an impaired function of the immunocompetent system one month after the treatment.20133878053
[use of thymalin in the complex treatment of infantile cerebral palsy].the immunomodulator thymalin was included in the complex of rehabilitative therapy of 22 children with cerebral paralysis expressed in the form of spastic diplegia and with frequent intercurrent infections. immunological parameters were measured before and after treatment to determine the efficiency of the therapy. improvement in the neurological defect was observed in 54.55% of children with an impaired function of the immunocompetent system one month after the treatment.20133878053
case records of the massachusetts general hospital. weekly clinicopathological exercises. case 4-1985. a 36-year-old man with a cardiac mass three years after renal transplantation. 19853880868
proteoglycans in pathological conditions: atherosclerosis.proteoglycans accumulate within the innermost layer (intima) of blood vessels during atherosclerosis. this accumulation is marked in some forms of human atherosclerosis and is particularly prominent in vessels that have been experimentally injured and have healed by the process of reendothelialization. the two major cell types of the arterial wall, endothelium and smooth muscle, are the major sources of arterial proteoglycans, and cell cultures have demonstrated that these cells synthesize at le ...19853881292
characterization with monoclonal antibodies of a surface antigen of plasmodium falciparum merozoites.the merozoite, the extracellular form of the erythrocyte stage of the malarial parasite, invades the erythrocyte and develops intracellularly. cloned hybridoma cell lines secreting monoclonal antibodies directed against the merozoite surface were selected by indirect immunofluorescent assay by using intact isolated merozoites. monoclonal antibodies to a 200,000 m.w. merozoite surface antigen were selected and were used to characterize this protein and its role in erythrocyte invasion. immunoelec ...19853881529
cholera and other vibrioses in the united states. 19853881668
[minimally transformed 3t3 cell lines as an object for research on the mechanisms of proliferation].the present review gives a detailed description of mouse cell lines 3t3 (swiss 3t3, balb/c 3t3, and nih 3t3) including their establishment, evolution, growth properties and formation of the specific monolayer with low saturation density. questionable views of the 3t3 cell origin are discussed. the main features of these continuous cell lines are shown, such as a high requirement for serum growth factors, substrate dependence, inhibition of cell division in dense monolayer and absence of oncogeni ...19853885522
evaluation of interferon treatment of cervical intraepithelial neoplasia. 20143885665
cloning and expression in escherichia coli of vibrio parahaemolyticus thermostable direct hemolysin and thermolabile hemolysin genes.two hemolysin genes of vibrio parahaemolyticus wp1, a thermostable direct (tsd) hemolysin gene and a thermolabile hemolysin gene, were cloned into the pbr322 vector in escherichia coli k-12 c600. a large amount of the tsd hemolysin produced in e. coli k-12 accumulated in the periplasmic space. the tsd hemolysin gene was localized on a 0.9-kilobase hindiii-bamhi fragment by identifying qualitatively the production of the tsd hemolysin by a reverse passive hemagglutination assay in the osmotic sho ...19853886626
shiga toxin--an expanding role in the pathogenesis of infectious diseases. 19853886803
[prof. aleksandr grigor'evich eletskiĭ (on the centenary of his birth)]. 20133887276
[prof. aleksandr grigor'evich eletskiĭ (on the centenary of his birth)]. 20133887276
a mutagen precursor in chinese cabbage, indole-3-acetonitrile, which becomes mutagenic on nitrite treatment.after treatment with nitrite, chinese cabbage showed direct-acting mutagenicity on salmonella typhimurium ta100 inducing 3100 revertants per g. one of the mutagen precursors that became mutagenic after nitrite treatment was isolated, and identified as indole-3-acetonitrile. after treatment with nitrite, 1 mg of indole-3-acetonitrile induced 17 400 revertants of ta100 and 21 000 revertants of ta98 without s9 mix.19853889600
repair of dna single-strand breaks in x-irradiated yeast. ii. kinetics of repair as measured by the dna-unwinding method.the kinetics of disappearance of single-strand breaks (ssb) from the dna of x-irradiated stationary yeast cells under liquid-holding conditions was found to proceed in a dose-independent manner up to a dose of at least 2400 gy, and was found to be complete after incubation of cells for 1 h. this was deduced from data for a yeast wild-type (wt) haploid and diploid strain as well as for rad52 haploid cells defective in dna double-strand break (dsb) repair. in all cases an initial fast repair compo ...19853889609
spontaneous mutagenesis: the roles of dna repair, replication, and recombination.there appears to be no dearth of mechanisms to explain spontaneous mutagenesis. in the case of base substitutions, data for bacteriophage t4 and especially for e. coli and s. cerevisiae suggest important roles in spontaneous mutagenesis for the error-prone repair of dna damage (to produce mutations) and for error-free repair of dna damage (to avoid mutagenesis). data from the very limited number of studies on the subject suggest that about 50% of the spontaneous base substitutions in e. coli, an ...19853889622
endoscopic visualization of the supravesical urinary tract: transurethral ureteropyeloscopy and percutaneous nephroscopy. 20123890060
endoscopic visualization of the supravesical urinary tract: transurethral ureteropyeloscopy and percutaneous nephroscopy. 20123890060
cardioprotective effects of defibrotide in acute myocardial ischemia in the cat.we investigated the effects of defibrotide (d), a natural polydeoxyribonucleotide, on acute myocardial ischemia (ami) in anesthetized cats. a permanent ligature was placed around the left anterior descending coronary artery (lad) 12-14 mm from its origin. ventricular fibrillation and death were exceptional and when they occurred the cats were not included in the evaluation. pretreatment of cats with d, 32 mg kg-1 h-1, i.v. infusion, maintained throughout the 5 h occlusion period, reduced ami-st ...19853890260
cardioprotective effects of defibrotide in acute myocardial ischemia in the cat.we investigated the effects of defibrotide (d), a natural polydeoxyribonucleotide, on acute myocardial ischemia (ami) in anesthetized cats. a permanent ligature was placed around the left anterior descending coronary artery (lad) 12-14 mm from its origin. ventricular fibrillation and death were exceptional and when they occurred the cats were not included in the evaluation. pretreatment of cats with d, 32 mg kg-1 h-1, i.v. infusion, maintained throughout the 5 h occlusion period, reduced ami-st ...19853890260
a comparative study of enterotoxigenic escherichia coli, shigella, aeromonas, and vibrio as etiologies of diarrhea in northeastern thailand.the incidence of enterotoxigenic escherichia coli (etec), shigella, aeromonas, and vibrio was determined in patients with diarrhea seen at a hospital in northeastern thailand, and compared with the incidence of these bacteria in household contacts and their neighbors. etec was identified in 17%, shigella in 9%, aeromonas in 9%, v. parahaemolyticus in 5%, and non-01 v. cholerae in 2% of 299 patients with diarrhea. these five species of bacteria were isolated more often from patients with diarrhea ...19853890578
the microbiology of cooked prawns and shrimps on retail sale.in an inter-laboratory survey, 148 samples of cooked prawns and shrimps were obtained at the point of sale to the consumer. salmonellae and vibrio parahaemolyticus were not detected. yersinia enterocolitica was isolated from three samples. results for total viable count and presence of escherichia coli and staphylococcus aureus complied well with available guidelines for imported cooked prawns, suggesting that the risk of food poisoning from retail samples of these foods in the south of england ...19853891850
[status of endemic leprosy in senegal in 1983]. 20143895804
postperfusion xenon-133 ventilation scintigraphy with a narrow window.xenon-133 postperfusion lung scintigraphy using 10% windows was compared with standard posterior preperfusion 133xe ventilation scanning in 33 patients. the postperfusion 133xe study identified all major defects and washout abnormalities. in five patients, the assessment of match or mismatch of defects was improved because of optimal positioning of the postperfusion ventilation study. computer subtraction of background technetium-99m macroaggregated albumin activity improved detection of mild wa ...20133895864
postperfusion xenon-133 ventilation scintigraphy with a narrow window.xenon-133 postperfusion lung scintigraphy using 10% windows was compared with standard posterior preperfusion 133xe ventilation scanning in 33 patients. the postperfusion 133xe study identified all major defects and washout abnormalities. in five patients, the assessment of match or mismatch of defects was improved because of optimal positioning of the postperfusion ventilation study. computer subtraction of background technetium-99m macroaggregated albumin activity improved detection of mild wa ...20133895864
rapidly progressive glomerulonephritis accompanying legionnaires' disease.a rapidly progressive, crescentic glomerulonephritis with acute oliguric renal failure occurred simultaneously with legionnaires' disease (ld) in a 52-year-old man. the diagnosis of ld was based on a sixfold rise in indirect fluorescent antibody titer against legionella pneumophila serogroup 4. treatment with erythromycin lactobionate resulted in a clinical resolution of pulmonary manifestations. the impairment of kidney function, however, was progressive and within two weeks led to end-stage re ...19853896188
rapidly progressive glomerulonephritis accompanying legionnaires' disease.a rapidly progressive, crescentic glomerulonephritis with acute oliguric renal failure occurred simultaneously with legionnaires' disease (ld) in a 52-year-old man. the diagnosis of ld was based on a sixfold rise in indirect fluorescent antibody titer against legionella pneumophila serogroup 4. treatment with erythromycin lactobionate resulted in a clinical resolution of pulmonary manifestations. the impairment of kidney function, however, was progressive and within two weeks led to end-stage re ...19853896188
canine distemper virus does not infect oligodendrocytes in vitro.dissociated canine brain cell cultures were infected with virulent canine distemper virus (cdv). double immunofluorescent labelling was done to simultaneously demonstrate viral antigen and specific glial cell markers. virus containing oligodendrocytes were not found at any stage of the infection. a certain proportion of the infected cells were shown to be astrocytes. it was concluded that cdv has no obvious tropism for oligodendrocytes which could explain the mechanism of demyelination in distem ...19853897461
long-term antiplatelet activity and safety of indobufen in patients with cardiovascular disease. italian multicenter study group.an open collaborative study was performed to assess the long-term platelet inhibiting activity, tolerability and safety of indobufen, a new inhibitor of platelet aggregation. the drug was given orally to 151 patients with cardiovascular disease for a period ranging from 6 to 24 months (mean 12.5 months). extensive clinical examination, laboratory investigations and platelet function studies were carried out before the treatment and at 1, 2, 3, 4, 5, 6, 8, 10, 12, 15, 18, 21 and 24 months. indobu ...20123899952
physiology of the upper airways in allergic disease. 20143902190
molecular assays for detection of ras oncogenes in human and animal tumors. 19853902219
comparison of the modified elek test and wagatsuma agar for determination of the kanagawa phenomenon of vibrio parahaemolyticus.the modified elek test and wagatsuma agar were compared for their ability to detect the kanagawa activity of 142 strains of vibrio parahaemolyticus. the performance of the modified elek test was on a par with that of the wagatsuma agar as far as positivity was concerned, and the test was far superior to wagatsuma agar in eliminating doubtful results. the results of the modified elek test were not unduly influenced by the different types of agar used.19853902884
[application of microassay to laboratory medicine--immunoassay in laboratory tests]. 20143903286
characterization of monoclonal antibodies against shiga-like toxin from escherichia coli.three monoclonal antibodies, designated mab 16e6, mab 13c4, and mab 19g8, were produced which recognize shiga-like toxin (slt) from escherichia coli. all three monoclonal antibodies neutralized the cytotoxicity of e. coli slt and were able to immunoprecipitate intact labeled toxin with staphylococcus aureus protein a. the three antibodies were of the g1 heavy and kappa light chain classes. mab 16e6 bound to the b subunit of slt in western blots and also neutralized the lethality of the toxin for ...19853905611
[the usefulness of kinetic studies and modeling in the study of apolipoprotein metabolism]. 20133910175
mechanism of sbcb-suppression of the recbc-deficiency in postreplication repair in uv-irradiated escherichia coli k-12.the mechanism by which an sbcb mutation suppresses the deficiency in postreplication repair shown by recb recc mutants of escherichia coli was studied. the presence of an sbcb mutation in uvra recb recc cells increased their resistance to uv radiation. this enhanced resistance was not due to a suppression of the minor deficiency in the repair of dna daughter-strand gaps or to an inhibition of the production of dna double-strand breaks in uv-irradiated uvra recb recc cells; rather, the presence o ...19853911022
pathophysiology of low density lipoprotein and high density lipoprotein glucosylation. 20143911060
values and structure in the german health care systems. 20143911098
[conservative treatment of injuries of the liver]. 20143911104
[results of the treatment of lymphatic neoplasms with vepeside]. 20143911173
specificity of surface molecules of adult brugia parasites: cross-reactivity with antibody from wuchereria, onchocerca and other human filarial infections.the extent of structural and immunological similarity between surface antigens of three species of brugia filarial parasites was studied by lodogen-mediated surface labelling of adult worms of b. malayi, b. pahangi and b. timori. the close homology and cross-reactivity between these antigens reported in previous surface labelling studies with bolton-hunter reagent, was verified in this system. the surface antigens of adult b. pahangi are also recognised by antibody from patients with wuchereria ...19853911361
immunodeficiency syndromes and the gut.the gastrointestinal tract in immunodeficiency disorders is involved with diseases similar to those seen in the immune competent. however, in some immune deficient states the incidence of gastrointestinal disease is high whereas in others it is no different than in the general population. this review clarifies the unique and specific abnormalities seen in immune deficient states and stresses the newest recognised abnormalities. it highlights the fact that the most frequent and severe abnormaliti ...20143911369
[alcohol, alcoholism and drugs].abuse of alcohol (ethanol) and abuse of an increasing number of drugs (e.g. analgesics and sedatives) are among the outstanding social and medical problems of many industrialized countries including switzerland. since alcohol consumption has profound effects on both the pharmacokinetic and pharmacodynamic actions of a variety of drugs, the rational use of drugs in alcoholics is an increasingly difficult task and requires a thorough understanding of the physiologic, biochemical, pharmacologic and ...20143911383
[history of the names for syphilis]. 20143911633
a mucoid, sucrose-positive vibrio parahaemolyticus strain isolated from diarrhoeal stool. 19853912993
human pancreatic growth hormone (gh)-releasing hormone stimulates gh synthesis and release in infant rats. an in vivo study.administration of human pancreatic gh-releasing factor 1-40 (hpgrf-40) at doses of 1, 10, 20, 100, and 500 ng/100 g bw sc induced in 10-day-old rats a clear-cut rise in plasma gh 15-min post-injection, although the effect was not dose-related and peak gh levels were already present after the lowest grf dose. in 25-day-old rats, hpgrf induced only a slight rise in plasma gh at the dose of 500 ng/100 g bw sc, whereas it was completely ineffective at the lower doses. in 5-day-old rats, hpgrf (20 ng ...19853917905
effect of valproic acid on behavior and plasma amino acid concentrations in chronic schizophrenic patients. 20143918589
interviewing the sexually abused child. 20143919238
[primary transport of acute patients. optimal use of rescue resources exemplified by the canton of graubünden]. 20113927607
[in vitro drug-sensitivity test using human tumor clonogenic assay in lung cancer patients].it would be helpful for successful chemotherapy in cancer patients if a drug-sensitivity test in vitro could predict the exact response of an individual patient's tumor. we have investigated a drug-sensitivity test using human tumor clonogenic assay since 1980. in this paper, results obtained in lung cancer patients are discussed. specimens for testing were obtained from primary tumor, metastatic mass, malignant pleural and pericardial effusion, and affected bone marrow. drugs tested in this stu ...19853927847
metabolism of 1-naphthol by tyrosinase.1-naphthol was metabolized by the polyphenol oxidase, tyrosinase, primarily to 1,2-naphthoquinone and to small amounts of 1,4-naphthoquinone as well as to covalently bound products. the inhibition of covalent binding by ethylenediamine, which reacts specifically with 1,2-naphthoquinone but not 1,4-naphthoquinone, suggested that most of the covalent binding was due to 1,2-naphthoquinone or a metabolite of similar structure. the activation by tyrosinase of 1-naphthol to covalently bound products s ...20143929786
t-lymphocyte subset phenotypes: a multisite evaluation of normal subjects and patients with aids.the present study was undertaken to determine normal ranges for blood lymphocytes labeled with the monoclonal antibodies okt3, okt11, okt4, and okt8 and for the okt4/okt8 ratio. in addition, 26 patients with aids, 51 aids suspects, and 44 patients with infections were studied. the results of these determinations from six different study sites indicate that there is excellent intersite agreement in normal values obtained. these normal ranges may be used in clinical laboratory reporting. data from ...20143930126
synthesis of dihomoprostaglandins from adrenic acid (7,10,13,16-docosatetraenoic acid) by human endothelial cells.human umbilical vein endothelial cells were found to contain adrenic acid (22:4) in their cellular lipids. since this fatty acid may be metabolized by cyclooxygenase in the kidney, the metabolism of adrenic acid was studied in endothelial cell cultures. [14c]adrenic acid was metabolized to several more polar metabolites. two of these metabolites co-migrated on hplc with 1 alpha,1 beta-dihomo-8-ketoprostaglandin f1 alpha (the metabolite of 1 alpha, 1 beta-dihomoprostaglandin i2) and 1 alpha,1 bet ...19853931686
the effects of glucose and an aldose reductase inhibitor on the sorbitol content and collagen synthesis of bovine retinal capillary pericytes in culture.the absolute rate of collagen synthesis by cultured bovine retinal capillary pericytes, determined using the specific radioactivity of proline in the cellular amino acid pool, was compared in media containing different concentrations of glucose (5, 10 or 40 mm) and sorbinil (0.0 or 0.1 mm), an inhibitor of aldose reductase. the absolute rate of collagen synthesis, in proline molar terms, by pericytes in medium with 5 mm glucose was 3.3 +/- 1.9 (s.d.) pmol 10(-7) cells 24 hr-1, and increased sign ...19853933992
modified taurocholate-tellurite-gelatin agar for improved differentiation of vibrio species.a total of 78 strains, representing 21 vibrio species, were examined by using taurocholate-tellurite-gelatin agar (ttga) medium and modified ttga medium containing 4-methylumbelliferyl-beta-d-galactoside (150 micrograms/ml). modified ttga medium allowed for simple and direct detection of beta-d-galactosidase (beta-gal) activity. this feature, in conjunction with other differential characteristics of ttga medium, gave improved differentiation of the vibrios tested. the modified ttga medium allowe ...19853934207
iohexol vs. metrizamide: study of efficacy and morbidity in cervical myelography.a double-blind study was conducted in 60 patients undergoing either cervical or more complete myelography via c1-c2 puncture. patients received either iohexol or metrizamide at a 300 mg l/ml concentration. the contrast media were equally efficacious in the production of high-quality radiographs and ct scans. however, the incidence of adverse reactions differed markedly. of patients receiving metrizamide, 68% had some type of adverse reaction, whereas only 26% receiving iohexol had symptoms. the ...20143934932
vasodilator drugs in patients with chronic ischaemic heart failure.the effects of intravenous nitroglycerin (ntg), trimetaphan (tmp), and phentolamine (ptl) on pulmonary artery diastolic pressure (padp), systemic arterial pressure (sap), cardiac index (ci) and systemic vascular resistance (svr) in patients (12 in each treated group) with chronic ischaemic heart failure are analyzed. each group was divided into two subgroups according to the initial padp taking into account the mean value in the whole group. a significant decrease in padp (by 40%; p less than 0. ...20133935374
ghrf test in acromegalic patients for the evaluation of therapeutic results.we studied here the clinical significance of ghrf test in evaluating therapeutic results in patients with acromegaly. three cases of acromegaly were studied at pre- and posttreatment. case 1 is a 42 year old woman, and her plasma gh showed slight increases responding to trh and arginine administration before therapy. eleven years after the pituitary irradiation, basal plasma gh decreased to low normal ranges and showed no response to the above two agents. only an insufficient increase in plasma ...19853937295
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