Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [helicobacter pylori: gastric ulcer and cancer]. | 1995 | 7638534 | |
| the best therapy for helicobacter pylori infection: should efficacy or side-effect profile determine our choice? | 1995 | 7638563 | |
| chronic gastritis in patients with gastric ulcer; a 10-year follow-up. | the course of gastric ulcer disease and its relations to certain indicators of inflammation and helicobacter pylori in the gastric mucosa were examined in a 10-year follow-up. | 1995 | 7638567 |
| avirulent, urease-deficient helicobacter pylori colonizes gastric epithelial explants ex vivo. | urease-negative helicobacter pylori generated by insertional mutagenesis fails to colonize gnotobiotic piglets, and this effect is largely independent of gastric ph. the purpose of this study was to determine whether urease-negative h. pylori colonized gastric explants ex vivo. | 1995 | 7638568 |
| [recurrent abdominal pain in children and helicobacter pylori]. | 1995 | 7638920 | |
| "cure" of helicobacter pylori and "cure" of peptic ulcer: do they mean the same thing? | 1995 | 7639214 | |
| recrudescence of helicobacter pylori infection in patients with healed duodenal ulcer after treatment with different regimens. | to determine the 12-month posttherapy recurrence (recrudescence) of helicobacter pylori in patients with healed duodenal ulcer after apparent eradication of the organism with anti-h. pylori treatment. the influence of original anti-h. pylori treatment regimens on the recrudescence was also evaluated. | 1995 | 7639218 |
| effect of administration of ranitidine bismuth citrate with food on the suppression and eradication of helicobacter pylori in infected volunteers. | this study examined the effect of administration with food on the ability of ranitidine bismuth citrate to suppress and eradicate helicobacter pylori in 41 infected volunteers. | 1995 | 7639229 |
| helicobacter pylori in patients with gastric and nongastric cancer. | to compare the seroprevalence of helicobacter pylori in gastric and nongastric carcinoma patients and to investigate the relationship between h. pylori, gastric cancer site, and histological type. | 1995 | 7639230 |
| restriction fragment length polymorphism in the adhesin gene hpaa of helicobacter pylori. | to assess the degree of restriction fragment length polymorphism (rflp) in the helicobacter pylori adhesin gene hpaa and to determine the molecular basis of rflp in this gene. | 1995 | 7639231 |
| gastrointestinal motility and helicobacter pylori infection in nonulcer dyspepsia. | 1995 | 7639256 | |
| fumarate reductase: a target for therapeutic intervention against helicobacter pylori. | the potential of fumarate reductase as a therapeutic target against the human pathogen helicobacter pylori was investigated by studying the cytotoxicity of morantel, oxantel, and thiabendazole, known to inhibit the enzyme in parasitic worms. nuclear magnetic resonance spectroscopy was employed to investigate the effects of the inhibitors on the fumarate reductase activity of laboratory-adapted and wild-type bacterial strains. production of succinate from fumarate in h. pylori cells was inhibited ... | 1995 | 7639515 |
| [helicobacter pylori infection in children]. | helicobacter pylori (hp) is a pathogen of human gastric mucosa and is considered as the major cause of chronic gastritis and duodenal ulcer disease recurrence. the prevalence rate of hp infection increases with age and is related to low socioeconomic status in childhood. childhood appears to be a high-risk period for hp infection. clinical and histological features of hp infection are variable and often moderate in children. this is probably due to both genetic and environmental factors. abdomin ... | 1995 | 7640761 |
| a biopsy urease test in the detection of helicobacter pylori: comparison of antral and body specimens. | this study was to compare the difference of positive rate and reaction time between the antrum and the body specimens in duodenal ulcer (n = 124) and non-duodenal ulcer (n = 181) patients. | 1995 | 7641120 |
| [gastric malt lymphoma of low-grade malignancy. apropos of 4 surgically treated cases]. | from 1990 to 1993, programmed surgery was performed in four patients with histologically low grade malignant gastric lymphomas of mucosa-associated lymphoid tissue (malt) (partial gastrectomy = 1, total gastrectomy = 3). these small cell lymphomas have the b phenotype and are uncommon. the clinical course is usually slow and classically limited to the stomach. as for other gastric lymphomas, there is still a certain amount of discussion as to the best therapeutic choice between surgery, chemothe ... | 1994 | 7641551 |
| migraine of gastrointestinal origin. | a consecutive series of 31 children (median age 12 years) suffering from migraine with (n = 21) or without (n = 10) aura underwent endoscopic oesophageal, gastric and duodenal biopsy in order to determine whether the complaints were of gastro-intestinal origin. of these 31 children, 13 (41.9%) showed oesophagitis, 16 (51.6%) gastritis of corpus, 12 (38.7%) antral gastritis and 27 (87.1%) duodenitis. thus, 29 of the 31 children studied had an underlying inflammatory lesion explaining their compla ... | 1995 | 7641777 |
| identification of two new genes in the pseudomonas aeruginosa amidase operon, encoding an atpase (amib) and a putative integral membrane protein (amis). | the nucleotide sequence of the amidase operon of pseudomonas aeruginosa has been completed and two new genes identified amib and amis. the complete gene order for the operon is thus amiebcrs. the amib gene encodes a 42-kda protein containing an atp binding motif that shares extensive homology with the clp family of proteins and also to an open reading frame adjacent to the amidase gene from rhodococcus erythropolis. deletion of the amib gene has no apparent effect on inducible amidase expression ... | 1995 | 7642533 |
| purification and characterization of ferritin from campylobacter jejuni. | we purified an iron-containing protein from campylobacter jejuni using ultracentrifugation and ion-exchange chromatography. electron microscopy of this protein revealed circular particles with a diameter of 11.5 nm and a central core with a diameter of 5.5 nm. the protein was composed of a single peptide of 21 kda and did not serologically cross-react with horse spleen ferritin. the uv-visible spectrum of the protein showed no absorption peaks in the visible region, indicating that little or no ... | 1995 | 7646314 |
| effects of flavonoids on parietal cell acid secretion, gastric mucosal prostaglandin production and helicobacter pylori growth. | the effect of the flavonoids flavone, flavanone and quercetin on parietal cell acid production, h+/k(+)-atpase activity, gastric mucosal prostaglandin e2 biosynthesis and helicobacter pylori growth was studied. all flavonoids inhibited acid production in isolated parietal cells in response to histamine and dibutyryl-camp stimulation (ic50 values between 26 and 139 mumol/l) and inhibited h+/k(+)-atpase activity. inhibition of h+/k(+)-atpase activity was dependent on the atp concentration. fluores ... | 1995 | 7646573 |
| [study on therapeutic mechanism of xi lei powder for peptic ulcer]. | we studied 128 patients with active peptic ulcer diagnosed by gastro-endoscopy four weeks after treatment with xi lei powder, pge2 levels in both serum and gastro-duodenal mucosa were significantly higher than that before the treatment, the difference was significant (p < 0.01). the rate of negative conversion of helicobacter pylori (hp) showed in 63.3% of cases. the distributed density of hp significantly reduced, the difference was significant (p < 0.01). these results indicated that xi lei po ... | 1995 | 7647543 |
| serum antibody against helicobacter pylori assayed by a new capture elisa. | we developed a highly specific detection technique for serum antibody, using a monoclonal antibody to a specific antigen of helicobacter pylori. a monoclonal antibody preparation that reacted with the 54-kda molecule of h. pylori antigens was obtained. using this preparation, an antigen-capture enzyme-linked immunosorbent assay (elisa) was established by fixation of the monoclonal antibody, followed by reaction with sonicated whole cell antigens. the serum antibody titers of patients with gastri ... | 1995 | 7647894 |
| lipid composition and fatty acid analysis of helicobacter pylori. | lipids extracted from helicobacter pylori were separated into lipid classes by thin-layer chromatography. simple h. pylori lipids consisted of cholesterol esters, triglycerides, free fatty acids, cholesterol, diacylglycerols, and monoacylglycerols. fatty acids were released from each lipid class by acid methanolysis, and analyzed by gas liquid chromatography and mass spectrometry. unique methoxy fatty acids, including 11-methoxy heptadecanoic and 11-methoxy nonadecanoic acids, were the major com ... | 1995 | 7647897 |
| omeprazole-amoxycillin therapy for eradication of helicobacter pylori in duodenal ulcer bleeding: preliminary results of a pilot study. | thirty-five patients with duodenal ulcer bleeding and helicobacter pylori-colonization were assigned to receive 2 x 20 mg omeprazole and 3 x 750 mg amoxycillin daily for 2 weeks. eradication was defined as no evidence of h. pylori infection by urease test and by histology 4 weeks after completion of therapy. two patients were lost to follow up. all ulcers healed completely (100% ulcer healing rate). twenty-nine out of the 33 patients were h. pylori-negative (87.9% eradication rate). three patien ... | 1995 | 7647898 |
| helicobacter pylori infection in perforated peptic ulcer disease. | 1995 | 7648182 | |
| inhibition of helicobacter pylori urease by phenyl phosphorodiamidates: mechanism of action. | helicobacter pylori urease is a nickel-containing enzyme that hydrolyzes urea to bicarbonate and ammonia. andrews et al. (j. am. chem. soc. 1986, 108, 7124) have shown that amides and esters of phosphoric acid are slow, tight-binding inhibitors of urease isolated from jack bean. we show that 4-substituted phenyl phosphorodiamidates (4-r-phop(=o)(nh2)2) are slow-binding inhibitors of h. pylori urease with no evidence of kinetic saturation. their second-order rates of inhibition ki are strongly co ... | 1995 | 7648208 |
| treatment of helicobacter pylori infections. | the available literature on the relationship between several diseases and helicobacter pylori (h. pylori) is reviewed. duodenal ulcer, gastric ulcer, complicated peptic ulcer, abdominal symptoms and gastroduodenal mucosal damage during the use of non-steroid anti-inflammatory drugs (nsaids), non-ulcer dyspepsia (nud) and gastric malignancy are discussed. the case for and against eradication is critically discussed. eradication of h. pylori should be pursued in all patients with peptic ulcer dise ... | 1995 | 7648229 |
| the relationship between the presence of helicobacter pylori, clostridium perfringens type a, campylobacter spp, or fungi and fatal abomasal ulcers in unweaned beef calves. | a case-control study involving 30 unweaned beef calves was conducted to determine whether specific species of bacteria or fungi were associated with fatal abomasal ulcer formation. special microbiological and histological techniques were used to detect clostridium perfringens type a, helicobacter pylori, or campylobacter spp. it has been speculated that these bacteria are potential ulcerogenic agents of unweaned beef calves. calves were recruited for the study at necropsy, with those dying of ei ... | 1995 | 7648542 |
| validation of a modified kirby-bauer disk diffusion method for metronidazole susceptibility testing of helicobacter pylori. | triple antimicrobial therapy that includes metronidazole has been recommended as a first-line therapy for helicobacter pylori because it has the highest eradication rates. however, resistance in h. pylori to metronidazole has been reported worldwide and its presence may reduce the efficacy of triple therapy. various methods for testing h. pylori against metronidazole have been used including agar dilution, disk diffusion and the etest but there has been little standardization of methods. one hun ... | 1995 | 7648834 |
| helicobacter pylori status, endoscopic findings, and serology in hiv-1-positive patients. | we have carried out a large prospective study of the frequency of h. pylori infection and hiv-1 status in a community of ex-drug abusers including subjects with (n = 210) and without (n = 259) upper gastrointestinal symptoms, endoscopy and serology. control groups were patients with upper gastrointestinal symptoms not at high risk of hiv-1 infection (n = 219) and asymptomatic blood donors (n = 322). h. pylori was present in 52% of symptomatic community residents having endoscopy and 55% of the c ... | 1995 | 7648959 |
| effect of eradication of helicobacter pylori infection on gastric epithelial cell proliferation. | helicobacter pylori infection has been linked with gastric carcinoma. epithelial cell proliferation is an indicator of cancer risk. the aim of this study was to assess gastric epithelial cell proliferation before and after eradication therapy and to assess the efficacy of treatment of h. pylori infection using lanzoprazole and clarithromycin. twenty-three patients with h. pylori-associated gastritis were treated with lanzoprazole 30 mg daily for four weeks and clarithromycin 500 mg three times a ... | 1995 | 7648960 |
| transport and storage of helicobacter pylori from gastric mucosal biopsies and clinical isolates. | various transport and storage conditions for the recovery of helicobacter pylori from gastric biopsies were evaluated. gastric mucosal biopsies from 16 helicobacter pylori-infected patients were stored in cysteine-albimi medium containing 20% glycerol in a refrigerator (4 degrees c) for 1 and 2 weeks and in a -20 degrees c laboratory freezer for 4 and 12 weeks. two clinical isolates were stored in saline, stuart's transport media, cysteine-albimi broth with 20% glycerol, brucella broth with 20% ... | 1995 | 7649201 |
| effect of an acidic environment on the susceptibility of helicobacter pylori to trospectomycin and other antimicrobial agents. | the susceptibility of 30 clinical isolates of helicobacter pylori to trospectomycin, ampicillin, metronidazole, clarithromycin, azithromycin and clindamycin under varying ph conditions was evaluated. an acidic environment was shown to affect unfavourably the activity of all the antimicrobial agents tested. this ph effect was most marked for the two macrolides and for clindamycin. | 1995 | 7649202 |
| seroepizootiology of helicobacter pylori gastric infection in nonhuman primates housed in social environments. | we determined the seroepizootiology of helicobacter pylori infection in rhesus monkeys. plasma was obtained from 196 animals (age range, 1 to 22 years) that were housed in social environments, either in indoor gang cages, in outdoor corrals, or in free-ranging forested conditions. plasma immunoglobulin g levels were determined with a specific enzyme-linked immunosorbent assay, and the cutoff immunoglobulin g value for h. pylori seropositivity was determined from a study of 25 monkeys whose infec ... | 1995 | 7650173 |
| serologic detection of infection with caga+ helicobacter pylori strains. | approximately 60% of helicobacter pylori isolates possess the caga gene and express its 120- to 140-kda product (caga). in this study, the caga gene was detected in h. pylori isolates from 26 (81.3%) of 32 patients with duodenal ulcers (du), 17 (68.0%) of 25 patients with gastric ulcers, and 23 (59.0%) of 39 patients with nonulcer dyspepsia (nud). by western blotting (immunoblotting) with antiserum to caga, in vitro caga expression was demonstrated for 95.5% of caga+ strains compared with 0% of ... | 1995 | 7650174 |
| prevalence of helicobacter pylori in family practice patients with refractory dyspepsia: a comparison of tests available in the office. | helicobacter pylori is emerging as an important cause of peptic disease; however, few studies have been performed in primary care settings. this study examines the prevalence of h pylori in a population of primary care patients with refractory dyspepsia and evaluates the usefulness of currently available h pylori tests. | 1995 | 7650503 |
| adaptation of the [13c]urea breath test as a noninvasive method for detection of helicobacter pylori infection in squirrel monkeys (saimiri spp.). | the [13c]urea breath test was adapted for use in squirrel monkeys (saimiri spp.) for identification of experimentally induced infection with helicobacter pylori, the bacterium causing gastric ulcer in humans. a canine anesthesia inhalation mask was modified with a volume-reducing insert allowing sufficient breath collection from these small primates within 30 sec. fourteen milligrams of [13c urea per kilogram of body weight was adequate for clear distinction between experimentally infected and n ... | 1995 | 7650891 |
| [the complement fixation reaction: a traditional, updated method for the detection of antibodies in the diagnosis of infections]. | complement-fixation (cf) is still an important basic serologic test for the diagnosis of infectious diseases. in several areas of microbiology (viral, bacterial, parasitic and fungal) it has served as a reference standard against which other methods have been compared. its partial displacement by other techniques, as advocated in some recent literature, is often unfounded and uncritical; displacement is mostly due not to problems inherent in the method, but rather to the lack of reagents of sati ... | 1995 | 7651069 |
| helicobacter pylori nickel-transport gene nixa: synthesis of catalytically active urease in escherichia coli independent of growth conditions. | urease is a virulence determinant, a taxonomic and diagnostic marker, and immunogen for helicobacter pylori, an aetiologic agent of gastritis and peptic ulceration. this enzyme requires ni2+ ions in the active site for successful hydrolysis of urea. when expressed in escherichia coli, recombinant urease is only weakly active unless urease structural subunits are overexpressed, exogenous nicl2 is added, and the host strain is grown in medium that does not chelate free ni2+. as wild-type h. pylori ... | 1995 | 7651142 |
| [helicobacter pylori-associated gastroduodenal pathology]. | 1995 | 7653123 | |
| peptic ulcer--a new look. | this review covers major advances in peptic ulcer disease over the last 25 years. flexible endoscopy enables accurate diagnosis of peptic ulcer to be made and its introduction made possible the large number of controlled clinical trials on the use of various agents in peptic ulcer treatment. the histamine h-2 receptor antagonists, which reduce gastric acid output, were the first major group of potent ulcer healing drugs introduced. subsequently, other ulcer healing agents with different modes of ... | 1995 | 7653963 |
| treatment of helicobacter pylori infection with a combination of itraconazole and omeprazole. | to determine the in vivo anti-microbial activity of a high-dose itraconazole and omeprazole regimen against helicobacter pylori. | 1995 | 7654896 |
| modulins: a new class of cytokine-inducing, pro-inflammatory bacterial virulence factor. | despite the fact that the inflammatory and immune responses have evolved to combat microorganisms, the present generation of inflammation researchers has evinced relatively little interest, with the exception of septic shock, in microbially-induced inflammation. this in spite of the fact that the gram-negative cell wall constituent, lipopolysaccharide, has been widely used as a tool in inflammation research. the reason for such lack of interest has been due to the therapeutic efficacy of antibio ... | 1995 | 7655992 |
| two-year follow-up of duodenal ulcer patients treated with omeprazole and amoxicillin. | the present study evaluated the time in remission during a 2-year follow-up after eradication of helicobacter pylori (hp) in patients with an hp-associated duodenal ulcer (du). hp was eradicated by combined treatment with high-dose omeprazole (2 x 40 mg) and amoxicillin (2 x 1,000 mg; n = 27) administered for 10 days (ome + amx); alternatively, patients were treated with omeprazole monotherapy (ome) using the same dosage (n = 25). during the 2-year follow-up period endoscopy including histologic ... | 1995 | 7657042 |
| helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. | the mechanism by which helicobacter pylori predisposes to duodenal ulcers (dus) remains unclear. the aim of this study was to investigate the effect of the infection on acid secretion. | 1995 | 7657096 |
| comparison of helicobacter mustelae and helicobacter pylori adhesion to eukaryotic cells in vitro. | bacterial adhesion to mucosal surfaces is an important pathogenic mechanism for helicobacter-induced gastritis. the aims of this study were to compare binding of selected helicobacter mustelae and helicobacter pylori strains to lipids extracted from hep-2, chinese hamster ovary, human embryonic lung cells, and ferret gastrointestinal tissues as well as to intact tissue culture cells and to analyze the fatty acids of the receptor. | 1995 | 7657097 |
| prevalence of helicobacter pylori infection in subtypes of gastric cancer. | although helicobacter pylori has already been declared a human carcinogen, the exact nature of the association with gastric cancer remains to be explored. the aim of this study was to determine if the association is confined to specific types of gastric cancer. | 1995 | 7657118 |
| resolution of helicobacter pylori-associated gastric lymphoproliferative disease in a child. | a possible causative association between helicobacter pylori infection and gastric lymphoproliferative disorders has recently been recognized. the case of a 14-year-old girl who was diagnosed with h. pylori gastritis and associated gastric lymphoproliferative disease of the low-grade mucosa-associated lymphoid tissue type is reported. the patient was treated only for the h. pylori infection (amoxicillin, bismuth, and metronidazole) without any adjuvant chemotherapy or surgery for her lymphoproli ... | 1995 | 7657127 |
| relationship of serum gastrin and helicobacter pylori in the gastric antral and body mucosa. | to evaluate the relationship between serum gastrin and helicobacter pylori status in the antrum and body of gastric mucosa. | 1995 | 7657374 |
| [helicobacter pylori and etiology of peptic ulcers]. | 1995 | 7658114 | |
| [clinical significance of clearing helicobacter pylori in the treatment of peptic ulcer]. | 1995 | 7658124 | |
| hyperammonaemia and helicobacter pylori. | 1995 | 7658863 | |
| helicobacter pylori infection in dentists--a case-control study. | to test the null hypothesis that frequent and multiple salivary exposure is not a risk factor for developing h. pylori infection, serum anti-h. pylori igg from 179 dentists and dental students and 179 age-, sex- and socioeconomic-matched controls were assayed using an elisa. seroprevalence in dentists was 16% (11/70); clinical dental students 6% (3/47); and pre-clinical dental students 10% (6/62). there were no differences in h. pylori seropositivity between cases and controls. there was an incr ... | 1995 | 7660079 |
| the gastric microenvironment determines helicobacter pylori colonization. | 1995 | 7661153 | |
| increase of helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for long-term safety. | helicobacter pylori causes chronic active gastritis with predominant localization in the gastric antrum. this predisposes to development of mucosal atrophy, intestinal metaplasia, and eventually, gastric cancer. the effects of acid suppression on h. pylori infection and associated gastritis are unclear. however rapid development of atrophic gastritis has been consistently observed in a number of studies during low acid output. we therefore studied the histological features of antrum and corpus o ... | 1995 | 7661157 |
| limited efficacy of omeprazole-based dual and triple therapy for helicobacter pylori: a randomized trial employing "optimal" dosing. | to evaluate the efficacy and side effects of dual omeprazole/amoxicillin therapy for helicobacter pylori given in "optimal" fashion (omeprazole twice a 3 g of amoxicillin daily, drugs started concurrently, 2 wk of therapy) and to assess the utility of adding a second antibiotic, tetracyline. | 1995 | 7661158 |
| treatment of helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin. | simpler, effective therapies to treat helicobacter pylori infection are greatly needed. omeprazole co-therapy apparently enhances effectiveness of some antimicrobials. our objective in this study was to determine whether the apparent additional benefit provided by omeprazole to amoxicillin therapy could be equaled by a high dose of ranitidine plus sodium bicarbonate. | 1995 | 7661159 |
| variability with omeprazole-amoxicillin combinations for treatment of helicobacter pylori infection. | although omeprazole co-therapy enhances the effectiveness of some antimicrobials for the treatment of helicobacter pylori infection, results have not been uniform. a meta-analysis suggested that 20 mg of omeprazole b.i.d. and 2 g or more of amoxicillin would yield a > 80% success rate (gastroenterology 1994; 106: 142a). our objective in this study was to test that hypothesis. | 1995 | 7661160 |
| effect of triple therapy or amoxycillin plus omeprazole or amoxycillin plus tinidazole plus omeprazole on duodenal ulcer healing, eradication of helicobacter pylori, and prevention of ulcer relapse over a 1-year follow-up period: a prospective, randomized, controlled study. | triple therapy and amoxycillin plus omeprazole are the two most widely recommended regimens for the eradication of helicobacter pylori. however, no controlled studies with a large number of cases are available for the reliable comparison of these two regimens. the aim of this controlled, randomized, prospective study was to compare the effect of these two regimens and a further regimen for metronidazole-resistant patients on duodenal ulcer healing, h. pylori eradication, and prevention of ulcer ... | 1995 | 7661161 |
| triple therapy with sucralfate, tetracycline, and metronidazole for helicobacter pylori-associated duodenal ulcers. | triple therapy with bismuth, metronidazole, and tetracycline or amoxicillin is effective for the treatment of helicobacter pylori, but side effects are common. sucralfate inhibits h. pylori hemagglutinin, protease, and lipase and thus might affect colonization of the bacterium in the stomach. | 1995 | 7661162 |
| gastric syphilis: endoscopic and histological features mimicking lymphoma. | the united states is currently experiencing a syphilis epidemic. we report three cases of gastric syphilis seen during a 1-yr period. these cases were endoscopically and microscopically confused with lymphoma. recent evidence has suggested that helicobacter pylori has a causative role in the development of gastric carcinoma, lymphocytic gastritis, and lymphoma, as well as peptic ulcer disease and chronic gastritis. during the same period of heightened awareness for the role of h. pylori-associat ... | 1995 | 7661178 |
| eradication of helicobacter pylori by a combination of amoxicillin and famotidine. | 1995 | 7661196 | |
| is short-term triple therapy with lansoprazole, clarithromycin, and metronidazole a definitive answer for helicobacter pylori eradication? | 1995 | 7661197 | |
| associations of peptic ulcer and gastric cancer with other diseases in us veterans. | the purpose of this study was to examine, through the database of the department of veterans affairs, the joint occurrence of different diseases in individual patients. | 1995 | 7661233 |
| how should we decide on the best regimen for eradicating helicobacter pylori? | 1995 | 7663243 | |
| helicobacter pylori: an update for primary care physicians. | it is now widely accepted that h. pylori plays an important role in gastritis and pud, and that eradication leads to a marked decrease in ulcer recurrence. h. pylori alone is not sufficient to cause ulcer disease. there is a complex interaction with acid production and mucosal protection. treatment that is directed only at reducing acid production heals ulcers and is safe, but is temporary at best and does not address the underlying etiology. currently treatment for h. pylori can only be recomme ... | 1995 | 7664540 |
| determinants of plasma pepsinogen levels in a population at high risk for stomach cancer in venezuela. | determinants of plasma pepsinogens (pg) levels were studied in 1365 participants in a chemoprevention trial for gastric pre-cancerous lesions being conducted in venezuela. gastric biopsies, plasma samples and information on smoking and dietary habits were obtained at baseline examination. both pg-i and pg-ii levels increased progressively with the level of helicobacter pylori infection in gastric biopsies, resulting in no clear trend in the i/ii ratio. instead, there was a progressive decrease i ... | 1995 | 7665219 |
| unique cholesteryl glucosides in helicobacter pylori: composition and structural analysis. | a chloroform-methanol-extracted lipid of helicobacter pylori was studied. three kinds of glycolipids, accounting for about 25% (wt/wt) of the total lipid, were detected and identified to be cholesteryl glucosides. the structures of two of them were determined to be cholesteryl-alpha-d-glucopyranoside and cholesteryl-6-o-tetrade-canoyl-alpha-d-glucopyranoside, and the plausible structure of the third one was identified as cholesteryl-6-o-phosphatidyl-alpha-d-glucopyranoside. cholesteryl glucoside ... | 1995 | 7665522 |
| histological findings in gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs. | to identify distinguishing and general histological features related to the use of non-steroidal anti-inflammatory drugs (nsaid). | 1995 | 7665699 |
| helicobacter pylori--associated chronic gastritis in peruvian adolescents is very common and severe. | 1995 | 7665829 | |
| gastric juice ascorbic acid after intravenous injection: effect of ethnicity, ph, and helicobacter pylori infection. | 1995 | 7666464 | |
| the treatment of helicobacter pylori infection in the management of peptic ulcer disease. | antimicrobial therapy against h. pylori is indicated for all patients with documented peptic ulcer disease who have evidence of the infection. the regimen of first choice, selected on the basis of available studies, is triple therapy with bismuth, metronidazole, and tetracycline (table 1). for patients who are known to have taken metronidazole previously, clarithromycin may be substituted for metronidazole. for patients with active, symptomatic peptic ulcers we also recommend an antisecretory dr ... | 1995 | 7666920 |
| bismuth subcitrate and omeprazole inhibit helicobacter pylorif1-atpase. | the effects of various types of antiulcer agents against helicobacter pylori f1-atpase were studied. atpase was released into the aqueous phase (i.e., solubilized) by sonication. the enzyme activity depended on mg2+, but not ca2+. the maximum activity occurred at an atp/mg2+ ratio of 1/5 and at ph 7.5. mg(2+)-dependent atpase activity was inhibited by sodium azide and the monovalent cations k+ and na+, but not by oligomycin, dicyclohexylcarbodiimide, ouabain, or sch 28080. the antiulcer agents r ... | 1995 | 7667394 |
| [the epidemiology of helicobacter pylori]. | 1995 | 7670307 | |
| [differential aggressiveness of helicobacter pylori]. | 1995 | 7670308 | |
| [helicobacter pylori infection and non-ulcer dyspepsia]. | 1995 | 7670310 | |
| [therapy of helicobacter pylori associated diseases]. | 1995 | 7670311 | |
| [helicobacter pylori and stomach tumors]. | 1995 | 7670313 | |
| brush cytology: helicobacter pylori and unexpected giardia. | 1995 | 7672565 | |
| transmission of helicobacter pylori infection. | 1995 | 7672655 | |
| ornithine decarboxylase as a marker for premalignancy in the stomach. | assessment of mucosal ornithine decarboxylase (odc) activity in the human large bowel may be of value as a marker of potential malignant risk. its value as a marker of premalignancy in the upper gastrointestinal tract is less clear. using a [14c]-ornithine bioassay, gastric mucosal odc activity was measured in 32 normal subjects and 22 patients with confirmed gastric cancer. these results were compared with 47 patients at increased risk of upper gastrointestinal malignancy, (32 patients with par ... | 1995 | 7672662 |
| a reliable cure for helicobacter pylori infection? | 1995 | 7672669 | |
| recrudescence of helicobacter pylori after apparently successful eradication: novel application of randomly amplified polymorphic dna fingerprinting. | the aim of this study was to find out if reinfection or recrudescence accounted for the recurrence of helicobacter pylori infections after apparent eradication of the bacterium. three hundred and twenty patients were treated with colloidal bismuth subcitrate (120 mg four times daily for four weeks), metronidazole and tetracycline (400 mg and 500 mg, respectively, thrice daily for the first week). h pylori was eradicated four weeks after the end of treatment as assessed by the rapid urease test, ... | 1995 | 7672675 |
| age dependent hypergastrinaemia in children with helicobacter pylori gastritis--evidence of early acquisition of infection. | acute helicobacter pylori associated gastritis causes achlorhydria, a powerful stimulus to gastrin secretion. if h pylori infection is acquired primarily in early childhood, then the degree of hypergastrinaemia in seropositive children should be age dependent. anti-helicobacter antibodies and fasting gastrin concentrations were measured in 439 children aged 4 to 13 years attending hospital for routine day case surgery not connected with any gastrointestinal disorder. thirty per cent were seropos ... | 1995 | 7672676 |
| intragastric acidity as a predictor of the success of helicobacter pylori eradication: a study in peptic ulcer patients with omeprazole and amoxicillin. | omeprazole plus amoxicillin cures helicobacter pylori infection. the hypothesis was tested that low acidity is a predictor of outcome. fifty patients with relapsing or complicated, or both h pylori positive duodenal (n = 25) or gastric ulcer (n = 25) were randomly treated with either omeprazole 20 mg twice daily plus amoxicillin 1 g twice daily or with omeprazole 40 mg twice daily plus amoxicillin 1 g twice daily over two weeks. after one week of combined treatment, a 24 hour gastric ph measurem ... | 1995 | 7672677 |
| helicobacter pylori infection and dental care. | sixty two patients (mean age 45.6 years) were assessed for oral hygiene and periodontal disease by dental examination before endoscopy. information about oral care, smoking, and dentures was obtained and samples of dental plaque collected. the presence of helicobacter pylori in plaque as sought by culture and polymerase chain reaction (pcr), and gastric antral biopsy specimens were taken for histological examination. although h pylori was detected in the antral specimens of 34 patients (54%) all ... | 1995 | 7672679 |
| does helicobacter pylori infection increase gastric sensitivity in functional dyspepsia? | the role of helicobacter pylori infection in the pathogenesis of functional dyspepsia is debated. it is known that a substantial fraction of dyspeptic patients manifest a low discomfort threshold to gastric distension. this study investigated the symptomatic pattern in 27 h pylori positive and 23 h pylori negative patients with chronic functional dyspepsia, and potential relations between infection and gastric hyperalgesia. specific symptoms (pain, nausea, vomiting, bloating/fullness, early sati ... | 1995 | 7672680 |
| cyto-secretory correlations (stimulated gastrinemia, parietal cell mass and acid secretion) in duodenal ulcer: role of helicobacter pylori. | 1995 | 7672772 | |
| suppression of acid secretion in peptic ulcer disease. | until recently, suppression of gastric acid secretion in patients with peptic ulcer was empirical and of unproven value. anticholinergic drugs had only modest inhibitory effects on acid secretion, many side effects, and uncertain efficacy. controlled trials using antacids demonstrated the value of reducing gastric acidity for healing duodenal ulcer. the discovery of histamine-2 (h2) receptor antagonists in the 1970s and the introduction of h+,k(+)-atpase inhibitors in the 1980s made reduction of ... | 1995 | 7673607 |
| adjuvant therapy for helicobacter pylori eradication: role of lansoprazole shown in vitro. | the recognition of helicobacter pylori (h. pylori) as a major cause of gastroduodenal diseases has led to the use of antibiotics to treat these diseases. however, antibiotics used alone are not very effective, and adjuvant therapy is required. the most potent adjuvant therapy consists of increasing the stomach ph with proton pump inhibitors (ppis). in addition to this action on stomach ph, ppis, and especially lansoprazole, have been found to have antimicrobial activity against h. pylori. at hig ... | 1995 | 7673610 |
| adjuvant therapy for helicobacter pylori eradication: role of lansoprazole in clinical studies. | helicobacter pylori (hp) eradication can lead to cure of duodenal ulcer. eradication of hp was first attempted with bismuth salts alone or in combination with one or two antibiotics. in 1990, triple therapy with bismuth, tetracycline or amoxicillin, and metronidazole or tinidazole was standard. proton pump inhibitors are active in vitro against hp and have therefore been tested in monotherapy, dual therapy, and triple therapy. when lansoprazole was used as monotherapy, the mean hp eradication wa ... | 1995 | 7673611 |
| antibacterial properties of lansoprazole alone and in combination with antimicrobial agents against helicobacter pylori. | the activities of various types of anti-ulcer agents against helicobacter pylori (hp) strains were determined using an agar dilution method. among the compounds tested, proton pump inhibitors were found to exhibit significant activity against this organism. the activity of lansoprazole was four times more potent than that of omeprazole and bismuth subsalicylate, with mics ranging from 1.56 to 25 micrograms/ml. exposure of hp to lansoprazole led to extensive loss of viability and suppression of v ... | 1995 | 7673612 |
| proton pump inhibitors for helicobacter pylori eradication in patients with peptic ulcer. | we investigated the effects of omeprazole or lansoprazole on peptic ulcer healing, eradication of helicobacter pylori (hp) and abdominal symptoms. a prospective, randomized study was performed for the administration of omeprazole or lansoprazole. hp-positive peptic ulcer patients (n = 86) were randomly assigned to two groups. gastric ulcer patients received omeprazole 20 mg once daily or lansoprazole 30 mg once daily for 8 weeks. duodenal ulcer patients were given omeprazole 20 mg once daily or ... | 1995 | 7673613 |
| the potential value of lansoprazole in helicobacter pylori eradication. | most anti-helicobacter pylori (hp) regimens available have drawbacks. standard triple therapy using bismuth, metronidazole, and tetracycline gives good eradication rates but at the expense of a long, complicated regimen associated with significant side effects, and results are not as good in areas where there is a high resistance to nitroimidazoles. the introduction of eradication regimens based on acid suppression in combination with antibiotics has yielded promising results. dual therapy using ... | 1995 | 7673614 |
| lansoprazole treatment of helicobacter pylori-positive peptic ulcers. | forty-nine patients with helicobacter pylori (hp)-positive gastric ulcer (gu) and 39 patients with hp-positive duodenal ulcer (du) were studied. before the trial and every 3 or 4 weeks, phenol red dye spraying endoscopy, the rapid urease test, biopsy specimen histology, and culture were performed to assess the ulcer stage and to detect hp. patients were divided into three groups: group i received lansoprazole 30 mg/d; group ii received dual therapy of lansoprazole 30 mg/day and amoxicillin (ampc ... | 1995 | 7673615 |
| isolation of helicobacter pylori from faeces. | 1995 | 7673752 | |
| [evaluation of contamination of the gastric mucosa with helicobacter pylori and activity of chronic gastritis]. | an objective method of histological evaluation of stomach mucosa contamination with h. pylori proposed by the authors comprises contamination index, contamination density, adhesion density, adhesion index. the response to antibacterial therapy and other factors can also be determined. chronic gastritis activity is characterized by the activity in surface area, in pits and in lamina propria. the method is simple, reproducible, time-effective, convenient both for diagnosis of chronic h. pylori gas ... | 1995 | 7677591 |
| cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of helicobacter pylori. | gene hpaa, which codes for the receptor-binding subunit of the n-acetylneuraminyllactose-binding fibrillar hemagglutinin (nlbh) of helicobacter pylori, was cloned and sequenced. the protein expressed by hpaa, designated hpaa, was identified as the adhesin subunit on the basis of its fetuin-binding activity and its reactivity with a polyclonal, monospecific rabbit serum prepared against nlbh purified from h. pylori. sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis and western bl ... | 1993 | 7678592 |
| serum 13c-bicarbonate in the assessment of gastric helicobacter pylori urease activity. | noninvasive detection of helicobacter pylori (hp) requires serum or salivary antibody testing or the co2 breath test. since gastric hp produces a potent urease, a meal rich in 13c-labeled urea should lead to a measurable quantity of isotopic co2 in the serum. this study investigates the feasibility, sensitivity, specificity, and potential of the measurement of serum 13c-bicarbonate (13chco3) in determining the presence of gastric hp. nineteen patients with upper gastrointestinal symptoms assesse ... | 1993 | 7679876 |
| structural analysis and demonstration of the 29 kda antigen of pathogenic entamoeba histolytica as the major accessible free thiol-containing surface protein. | the 29 kda protein of pathogenic entamoeba histolytica is a cysteine-rich surface antigen which we recently characterized by cdna sequencing and by using monoclonal antibodies which differentiated between pathogenic and non-pathogenic clinical isolates. to determine the structure and biochemical attributes of this protein, a repertoire of immunological techniques using monoclonal antibodies, and radiolabelling were employed. we demonstrated that the 29 kda protein forms a 60 kda dimer and a high ... | 1993 | 7682280 |
| affinity of the gastric pathogen helicobacter pylori for the n-sulphated glycosaminoglycan heparan sulphate. | binding of 125i-heparan sulphate was a common property of helicobacter pylori strains isolated from patients with gastroduodenal ulcer diseases. binding was (i) saturable; (ii) reversible by the addition of unlabelled heparan sulphate and heparin; (iii) inhibited by unlabelled heparan sulphate, heparin, and heparin oligosaccharides but not by other glycosaminoglycans of comparable size (chondroitin sulphate and dermatan sulphate) or by highly glycosylated glycoproteins (hog gastric mucin and fet ... | 1993 | 7682621 |