Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| postmitotic neurons migrate tangentially in the cortical ventricular zone. | patterns of cell movement play a key role in the establishment of the brain's functional architecture during development. the migration of neuronal progenitor cells has been hypothesized to disperse clonally related cells among different areas of the developing cerebral cortex. to test this model, we explored the migratory patterns of cells in the proliferative zone of the intact cortex of the ferret. after focal injections of dii, labeled cells migrated in all directions and over long distances ... | 1997 | 9056775 |
| effect of nicotine on large bowel mucus thickness, eicosanoids and faecal proteinase in ferrets. | following observations on the effect of subcutaneous nicotine on rectal mucosal eicosanoids and mucus in the rabbit we have repeated the work in ferrets which may be a more suitable animal model. | 1997 | 9058630 |
| heterogeneity in k+ channel transcript expression detected in isolated ferret cardiac myocytes. | the molecular basis of the potassium ion (k+) channels that generate repolarization in heart tissue remains uncertain, in part because of the molecular diversity of the voltage-gated k+ channel family. in our investigation, we used fluorescent labeled oligonucleotide probes to perform in situ hybridization studies on enzymatically isolated myocytes to determine the identity, regional distribution, and cellular distribution of voltage-gated k+ channel, alpha-subunit mrna expressed in ferret heart ... | 1997 | 9058843 |
| genetically engineered live attenuated influenza a virus vaccine candidates. | we have generated new influenza a virus live attenuated vaccine candidates by site-directed mutagenesis and reverse genetics. by mutating specific amino acids in the pb2 polymerase subunit, two temperature-sensitive (ts) attenuated viruses were obtained. both candidates have 38 degrees c shutoff temperatures in mdck cells, are attenuated in the respiratory tracts of mice and ferrets, and have very low reactogenicity in ferrets. infection of mice or ferrets with either mutant conferred significan ... | 1997 | 9060631 |
| mechanisms of positive inotropic action of flosequinan, hydralazine, and milrinone on mammalian myocardium. | flosequinan is an arterial and venous dilator that also has a positive inotropic effect at relatively higher doses. the purpose of this study was to determine the mechanism of this positive inotropic effect in ferret papillary muscles loaded with the ca2+ indicator, aequorin. over the range of doses from 10(-6) to 10(-3) m, flosequinan produced a 61 +/- 9% increase in peak tension that was accompanied by a corresponding increase in [ca2+]i. this positive inotropic effect was not selectively bloc ... | 1997 | 9063689 |
| the tachykinin nk1 receptor antagonist pd 154075 blocks cisplatin-induced delayed emesis in the ferret. | the activity of a selective tachykinin nk1 receptor antagonist, pd 154075 ([(2-benzofuran)-ch2oco]-(r)-alpha-metrp-(s)-nhch(ch3) ph), was examined in radioligand binding studies, in a [sar9,met(o2)11]substance p-induced foot-tapping model in the gerbil, and in cisplatin-induced acute and delayed emesis in the ferret. in radioligand binding studies, pd 154075 showed nanomolar affinity for the human, guinea-pig, gerbil, dog and ferret nk1 receptors with an approximate 300 times lower affinity for ... | 1997 | 9063690 |
| an overview of randomised studies comparing 5-ht3 receptor antagonists to conventional anti-emetics in the prophylaxis of acute chemotherapy-induced vomiting. | ten years after it was demonstrated in the ferret that cisplatin-induced emesis could be blocked by the selective 5-ht3 receptor antagonist mdl 72222, 5-ht3 receptor antagonists have become routine anti-emetic agents for chemotherapy-induced emesis. however, although in association with highly emetogenic, mainly cisplatin-containing regimens, the use of these agents is well justified, the net benefit of 5-ht3 receptor antagonists in association with moderately emetogenic regimens has not been th ... | 1997 | 9071902 |
| chey-mediated modulation of campylobacter jejuni virulence. | four motile, non-adherent and non-invasive mutants of campylobacter jejuni 81-176 generated by a site-specific insertional mutagenesis scheme were characterized at the molecular level and all contained a duplication of the same region of the chromosome. when this region was cloned from wild-type 81-176 and transferred into 81-176 on a shuttle plasmid, the same non-invasive phenotype as the original mutants was observed, suggesting that the region contained a repressor of adherence and invasion. ... | 1997 | 9076738 |
| adrenal gland disease in ferrets. | adrenocortical disease is a frequent problem affecting pet ferrets in the united states. this article describes the typical history, signs, and diagnostic test results to be expected in ferrets with this disease. treatment options are discussed. a newly developed diagnostic technique is also described. | 1997 | 9076915 |
| gastrointestinal motor activity in conscious ferrets. | gastrointestinal motility was measured with force transducers in conscious ferrets. the gastrointestinal motility pattern in both the interdigestive and digestive states was similar to that reported for humans. the activity front, phase iii contractions of the migrating motor complex, occurred cyclically in the antrum and migrated to the duodenum and ileum in the interdigestive state, and relatively low-amplitude contractions were sustained in the antrum, duodenum and ileum in the digestive stat ... | 1997 | 9083786 |
| antiemetic effects of n-3389, a newly synthesized 5-ht3 and 5-ht4 receptor antagonist, in ferrets. | the antiemetic activity of n-3389 (endo-3,9-dimethyl-3,9-diazabicyclo[3,3,1]non-7-yl-1 h-indazole-3-carboxamide dihydrochloride), a new 5-ht3 and 5-ht4 receptor antagonist, against cisplatin-, cyclophosphamide- and copper sulfate-induced emesis was investigated using ferrets. we also examined the effects of these agents on abdominal afferent vagus nerve activity in anesthetized ferrets. both intraperitoneal (0.1-1.0 mg/kg) and oral (0.1-1.0 mg/kg) administration of n-3389 produced dose-dependent ... | 1997 | 9085045 |
| chronotopic fiber reordering and the distribution of cell adhesion and extracellular matrix molecules in the optic pathway of fetal ferrets. | we have examined the age-related reordering of optic axons as they pass through the chiasmatic region in fetal ferrets. proportions of young and old optic axons were determined from electron micrographs taken sequentially through the prechiasmatic nerve, chiasm, and tract. this "chronotopic" reordering of axons was shown to emerge gradually, beginning rostral to the fusion of the two optic nerves, but continuing to develop caudal to the chiasmatic midline. segregation of young from old optic axo ... | 1997 | 9087518 |
| the actions of ondansetron and dexamethasone to antagonise cisplatin-induced emesis in the ferret. | the ability of ondansetron and dexamethasone to antagonise cisplatin 10 mg/kg i.p. induced emesis was investigated in the ferret during a 24 h period. ondansetron 0.5-5 mg/kg, as a single injection, effectively antagonised the response for approximately 4 h and revealed a subsequent response that was sensitive to further ondansetron treatment. the three times per day administration of dexamethasone 1 mg/kg i.p. alone or combined with ondansetron 1 mg/kg i.p. significantly reduced the vomiting re ... | 1997 | 9088874 |
| centromeres, cenp-b and tigger too. | the highly conserved centromere-associated protein cenp-b is a common feature of mammalian centromeres. binding sites for cenp-b, so-called 'cenp-b boxes', are present in the otherwise unrelated centromeric satellite dnas of humans, mus musculus, mus caroli, ferrets, giant pandas, tree shrews and gerbils, suggesting a role for cenp-b in centromere function. however, cenp-b and its binding sites are not detected at the centromeres of mammalian y chromosomes and few, if any, binding sites seem pre ... | 1997 | 9097724 |
| effect of timing of treatment of the glyburide-reversible cardioprotective activity of bms-180448. | the effect of the timing of treatment with the atp-regulated potassium channel agonist bms-180448 was evaluated in isolated rat heart and ferret models of ischemia and reperfusion. in rat hearts, 10 microm bms-180448, given before and after global ischemia as well as only during reflow, improved reperfusion contractile function and attenuated lactic dehydrogenase release, although reperfusion-only treatment was less effective. cromakalim (10 microm) and bimakalim (10 microm) treatment before and ... | 1997 | 9103476 |
| alpha 2-antiplasmin causes thrombi to resist fibrinolysis induced by tissue plasminogen activator in experimental pulmonary embolism. | in patients with pulmonary embolism, thrombi resist fibrinolysis induced by plasminogen activators. because the molecular basis of this thrombus resistance is poorly understood, we used a potent inhibitor to examine the potential role of alpha 2-antiplasmin (alpha 2ap) in experimental pulmonary embolism. | 1997 | 9107177 |
| biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. | the 6-hydroxylation of chlorzoxazone (clz) is currently being used in both in vivo and in vitro studies to quantify cytochrome p450 2e1 (cyp2e1) activity in humans. comparatively little is known with regard to the biotransformation of this drug in other species. the nadph-dependent biotransformation of clz was therefore studied using hepatic microsomes derived from humans and ten other mammalian species. in all species, 6-hydroxychlorzoxazone (6oh-clz) was the only metabolic product that could b ... | 1997 | 9113344 |
| species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin-3 in mammalian ventricular myocardium. | 1. species-dependent variations in the positive inotropic effect (pie) of endothelin-3 (et-3), and the relationships between the pie and specific binding sites for [125i]-et-3 and the pie and the acceleration of phosphoinositide hydrolysis by et-3, were studied in ventricular muscles from the rat, guinea-pig, rabbit, ferret and dog. 2. et-3 in the presence of (+/-)-bupranolol (0.3 microm) and prazosin (0.3 microm) elicited a concentration-dependent pie in the ventricular muscle from the rat, gui ... | 1997 | 9113371 |
| [chemotherapy-induced nausea and vomiting: from experimentation to experience]. | chemotherapy-induced nausea and vomiting, two of the most distressing side-effects of cancer chemotherapy, have been the subject of a number of fundamental and clinical investigations. these have led to the development of a novel class of antiemetic agents, the 5-ht3 receptor antagonists. the pathophysiology of the emetic reflex and the clinical management of emesis are very complicated. two experimental preclinical animal models are available (ferret and dog) and are particularly used to assess ... | 1996 | 9116365 |
| dynamics of functional connectivity in visual cortical networks: an overview. | the aim of the royaumont symposium was to review various dynamic aspects of adaptive changes in functional connectivity, expressed in cortical networks during development, learning, and possibly during recognition and cognitive processing. the link between the various experimental and theoretical models was the comparison of cellular and molecular mechanisms that could be involved in the up- and down-regulation of functional connectivity, over different time scales. these processes have been inv ... | 1996 | 9116656 |
| the effect of cp-99994 on the responses to provocative motion in the cat. | 1. the nk1 receptor antagonist cp-99994 has been shown to prevent vomiting elicited by both peripherally and centrally acting emetogens in ferrets and dogs. these results have now been extended to another stimulus, provocative motion, and another species, the cat. 2. cp-99994 displaced [3h]-substance p from cat cortex with ic50 of 0.52 +/- 0.08 nm. following s.c. administration, peak plasma drug levels were achieved at 30 min. the plasma drug half life was 1.4 h. 3. subcutaneous administration o ... | 1997 | 9117085 |
| tachykinin nk1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. | these studies have compared the pharmacological profile of two non-peptide human type neurokinin1 (hnk1) receptor selective antagonists, l-741,671 and a quaternised compound l-743,310. in radioligand binding studies l-741,671 and l-743,310 had high affinity for ferret and cloned hnk1 receptors [ki (nm) ferret 0.7 and 0.1; human 0.03 and 0.06, respectively] but low affinity for rodent nk1 receptors [ki (nm) 64 and 17, respectively] suggesting that ferret receptors have hnk1-like binding pharmacol ... | 1996 | 9121615 |
| synovial sarcoma in a ferret. | 1996 | 9123789 | |
| infection of the ferret stomach by isogenic flagellar mutant strains of helicobacter mustelae. | helicobacter mustelae, like helicobacter pylori, possesses two flagellin proteins, flaa and flab. isogenic mutant strains of h. mustelae have been constructed by disruption of the flaa or flab gene with a kanamycin resistance cassette or by introduction of both a kanamycin and a chloramphenicol resistance gene to produce a double mutant. to determine whether one or both flagellin proteins are necessary for colonization and persistence of infection with h. mustelae, 19 ferrets, specific pathogen ... | 1997 | 9125590 |
| immunoelectron microscopy of corticotropes and melanotropes in the pituitary gland of the european ferret, mustela putorius furo. | the superimposition technique and protein a-gold method of immunoelectron microscopy were employed to study the ultrastructure of corticotropes as well as melanotropes in the ferret pituitary gland. this is the first study ever elucidating the ultrastructural heterogeneity of melanotropes in mammalian pars intermedia on an immunocytochemical basis. morphological heterogeneity of pars distalis corticotropes has also been elucidated. it is suggested that the different subtypes may represent stages ... | 1996 | 9142335 |
| care of ferrets. | 1997 | 9149371 | |
| epidemiological analysis of malassezia pachydermatis isolates by partial sequencing of the large subunit ribosomal rna. | the opportunistic yeast malassezia pachydermatis is commonly recovered from both normal and diseased skin of warm-blooded animals. the diversity of m pachydermatis isolates obtained from a wide range of hosts was investigated by the partial sequencing of the large subunit (lsu) ribosomal rna. among 100 isolates examined, seven types (ia-ig) were discriminated on the basis of nucleotide sequence diversity. the seven types differed by one to five mutations, all of them corresponding to transitions ... | 1997 | 9160419 |
| a single-tube nested pcr for pneumocystis carinii f. sp. hominis. | a single-tube nested pcr which amplifies the internal transcribed spacer (its) regions of the rrna genes of human pneumocystis carinii was developed. the outer primers for the first pcr, which anneal to the 18s and the 26s rrna genes of p. carinii, were made to have a midpoint temperature (tm) of 74 degrees c. the inner primers for the second pcr have a tm of 56 to 58 degrees c and are specific for human p. carinii; they anneal to an area close to the beginning of its1 and the junction of its2 a ... | 1997 | 9163492 |
| helicobacter mustelae-associated gastric adenocarcinoma in ferrets (mustela putorius furo). | helicobacter pylori in humans is associated with active, chronic gastritis, peptic ulcer disease, and most recently has been linked epidemiologically to gastric adenocarcinoma. a related organism, helicobacter mustelae, naturally infects ferrets and also causes a persistent gastritis, a precancerous lesion, and focal glandular atrophy of the proximal antrum. in this report, we document the clinical presentation and histopathologic confirmation of h. mustelae-associated gastric adenocarcinoma in ... | 1997 | 9163879 |
| sexually dimorphic activation of midbrain tyrosine hydroxylase neurons after mating or exposure to chemosensory cues in the ferret. | mating with intromission induces a prolonged preovulatory lh surge in the estrous female ferret but inhibits lh secretion in the male. we used the dual immunocytochemical localization of fos (as a marker of neural activation) and tyrosine hydroxylase (th) to determine whether neurons containing norepinephrine or other catecholamines are activated after mating. breeding male ferrets were allowed to intromit with estrous females; both animals were perfused 90 min after the onset of intromission. o ... | 1997 | 9166692 |
| [hyperadrenocorticism in ferrets]. | 1997 | 9173596 | |
| the effect of ca(2+)-calmodulin-dependent protein kinase ii on cardiac excitation-contraction coupling in ferret ventricular myocytes. | 1. the effect of ca(2+)-calmodulin-dependent protein kinase ii (camkii) on excitation-contraction coupling (e-c coupling) was studied in intact ferret cardiac myocytes using the selective inhibitor kn-93, kn-93 decreased steady-state (ss) twitch [ca2+]i (by 51%), resting ca2+ spark frequency (by 88%) and ss sarcoplasmic reticulum (sr) ca2+ content evaluated by eaffeine application (by 37.5%). 2. increasing extracellular ca2+ concentration ([ca2+]o) to 5 mm in kn-93 restored sr ca2+ load and ca2+ ... | 1997 | 9174990 |
| sources of subcortical projections to the superior colliculus in the ferret. | we have identified brainstem and other subcortical afferents to the superior colliculus (sc) in the ferret, by examining the pattern of retrograde labelling that resulted from unilateral injections of red and green fluorescent latex microspheres or of wheat germ agglutinin conjugated to horseradish peroxidase into different regions of this midbrain nucleus. labelled neurons were found in many structures, including somatosensory, visual and auditory nuclei. these subcortical inputs are almost all ... | 1997 | 9175895 |
| glial organization and chondroitin sulfate proteoglycan expression in the developing thalamus. | this study examines the early organization of glial cells, together with the expression of chondroitin sulfate proteoglycans in the developing thalamus of ferrets. glia were identified with antibodies against vimentin and glial fibrillary acidic protein and the chondroitin sulfate proteoglycans were identified by using an antibody against chondroitin sulfate side chains. our results reveal three striking features of early thalamic development. first, there is a distinct population of glial fibri ... | 1997 | 9181483 |
| protective vaccination of ferrets against canine distemper with recombinant pox virus vaccines expressing the h or f genes of rinderpest virus. | to investigate the ability of rinderpest virus (rpv) antigens, expressed in pox virus vectors, to protect against canine distemper virus (cdv) infection in ferrets. | 1997 | 9185963 |
| influence of psychogenic and neurogenic stressors on endocrine and immune activity: differential effects in fast and slow seizing rat strains. | variations of plasma acth and corticosterone, as well as splenic macrophage activity and mitogen-induced cell proliferation, were determined in rats following 15 min of either the neurogenic stressor of restraint or by a purely psychogenic stressor consisting of exposure to a ferret. the effects of these stressors were assessed in two strains of rats that were selectively bred for either fast or slow kindling epileptogenesis triggered in response to amygdala stimulation. the stressors differenti ... | 1997 | 9193768 |
| in vitro and in vivo predictors of the anti-emetic activity of tachykinin nk1 receptor antagonists. | the ability of tachykinin nk1 receptor antagonists to inhibit gr73632 (d-ala-[l-pro9,me-leu8]substance p-(7-11))-induced foot tapping in gerbils was employed as an indirect measure of brain penetration and this was compared with their ability to prevent acute emesis induced by cisplatin in ferrets. (+)-gr203040 ((2s,3s and 2r,3r)-2-methoxy-5-tetrazol-1-yl-benzyl-(2-phenyl-piperidin- 3-yl)-amine), cp-99,994 ((2s,3s)-cis-3-(2-methoxybenzylamino)-2-phenyl piperidine) dihydrochloride), and l-742,694 ... | 1997 | 9196273 |
| steroids reduce the periapical inflammatory and neural changes after pulpectomy. | root canal treatment, including obturation with gutta-percha and a zinc oxide and eugenol sealer, was conducted, under general anesthesia, on the canine teeth of 12 young ferrets. six of the ferrets were given 0.5 mg/kg dexamethasone daily. three months after the root canal treatment, under general anesthesia, the animals were perfused with fixative and the canine periapical tissues prepared for histological examination. the extent of periapical inflammation was measured and the degree of neural ... | 1996 | 9198424 |
| clonal dispersion and evidence for asymmetric cell division in ferret cortex. | cell lineage analysis with retroviral libraries suggests that clonal progeny disperse widely in rodent cortex. to determine whether widespread dispersion is a general mammalian plan and to investigate phylogenetic differences in cortical development, we analyzed cell lineage in the ferret, a carnivore and near relative of the cat. the ferret possesses a highly developed, folded cerebral cortex, characteristic of higher mammalian species. progenitor cells of the ferret cerebral cortex were tagged ... | 1997 | 9199370 |
| regional localization of erg, the channel protein responsible for the rapid component of the delayed rectifier, k+ current in the ferret heart. | repolarization of the cardiac action potential varies widely throughout the heart. this could be due to the differential distribution of ion channels responsible for repolarization, especially the k+ channels. we have therefore studied the cardiac localization of erg, a channel protein known to play an important role in generation of the rapid component of the delayed rectifier k+ current (ikr), an important determinant of the repolarization waveform, cryosections of the ferret atrium and ventri ... | 1997 | 9201036 |
| are known pyrogenic cytokines responsible for fever in influenza? | the levels of interleukin (il)-1 beta, il-6, tumour necrosis factor (tnf)-alpha, and macrophage inflammatory protein (mip)-1 alpha released from human peripheral blood leucocytes (pbl) following interaction with influenza virus clone 7a (virulent, produces high fever in ferrets) and a/fiji (attenuated, produces relatively low fever in ferrets) were low and similar for the two viruses. neither strain induced interferon (ifn)-gamma and release of il-8 (which occurs on incubation of pbls alone) was ... | 1997 | 9210046 |
| synchronized oscillations in the inferior olive are controlled by the hyperpolarization-activated cation current i(h). | the participation of a hyperpolarization-activated cationic current in the generation of oscillations in single inferior olive neurons and in the generation of ensemble oscillations in the inferior olive nucleus (io) of the guinea pig and ferret was investigated in slices maintained in vitro. intracellular recordings in guinea pig or ferret 10 neurons revealed that these cells could generate sustained endogenous oscillations (4-10 hz) at hyperpolarized membrane potentials (-60 to -67 mv) after t ... | 1997 | 9212264 |
| helicobacter mustelae-associated gastric malt lymphoma in ferrets. | gastric lymphoma resembling gastric mucosa-associated lymphoid tissue (malt) lymphoma linked with helicobacter pylori infection in humans was observed in ferrets infected with h. mustelae. four ferrets with ante- or postmortem evidence of primary gastric lymphoma were described. lymphoma was diagnosed in the wall of the lesser curvature of the pyloric antrum, corresponding to the predominant focus of h. mustelae induced gastritis in ferrets. two ferrets had low-grade small-cell lymphoma and two ... | 1997 | 9212752 |
| development of primary visual projections occurs entirely postnatally in the fat-tailed dunnart, a marsupial mouse, sminthopsis crassicaudata. | we have examined the development of retinal projections in a diminutive polyprotodont marsupial, the fat-tailed dunnart, sminthopsis crassicaudata. here, we document the most immature mammalian visual system at birth described to date. at postnatal day (p) 0, the retinal ganglion cell layer has yet to form, and axons have not entered the optic stalk. by p4, the retinal ganglion cell layer could be distinguished at the posterior pole, and the front of growing axons extended one-third the length o ... | 1997 | 9214538 |
| distribution of technetium 99m-labeled red blood cells during isoflurane anesthesia in ferrets. | to address the physiologic mechanism of isoflurane-associated reduction in hematologic variables in ferrets. | 1997 | 9215458 |
| functional characterization of monoclonal antibody inhibitors of alpha 2-antiplasmin that accelerate fibrinolysis in different animal plasmas. | in humans with acute thrombotic disease, thrombi often appear to resist fibrinolysis induced by plasminogen activators. to examine the potential role of alpha 2-antiplasmin (alpha 2ap) in thrombus resistance in vivo, we generated monoclonal antibody inhibitors of alpha 2ap. in a somatic cell fusion, 99 hybridomas were obtained that produced mabs that bound to human 125i-alpha 2ap in a capture assay. screening assays showed that 3 of these mabs, 49, 70, and 77, neutralized the function of alpha 2 ... | 1997 | 9219039 |
| comparison of the 16s ribosomal dna sequences from the intracellular agents of proliferative enteritis in a hamster, deer, and ostrich with the sequence of a porcine isolate of lawsonia intracellularis. | proliferative enteritis is an enteric disease that affects a variety of animals. the causative agent in swine has been determined to be an obligate intracellular bacterium, lawsonia intracellularis, related to the sulfate-reducing bacterium desulfovibrio desulfuricans. the intracellular agents found in the lesions of different animal species are antigenically similar. in addition, strains from the pig, ferret, and hamster have been shown to be genetically similar. in this study we performed a pa ... | 1997 | 9226893 |
| the expanding genus of helicobacter: pathogenic and zoonotic potential. | the microbial flora of stomachs of humans and animals have been the focus of considerable research since the discovery that helicobacter pylori in humans caused a variety of gastric diseases. other helicobacter species have now been isolated from the stomachs of various mammals, including dogs, cats, ferrets, pigs, monkeys, and cheetahs, all of which are associated with various degrees of gastritis in their hosts. helicobacter species have also been isolated from the intestinal tracts of humans, ... | 1997 | 9232726 |
| bilateral disruption of conditioned responses after unilateral blockade of cerebellar output in the decerebrate ferret. | 1. lesions of the cerebellar cortex can abolish classically conditioned eyeblink responses, but some recovery with retraining has been observed. it has been suggested that the recovered responses are generated by the intact contralateral cerebellar hemisphere. in order to investigate this suggestion, bilaterally acquired conditioned responses were studied after the unilateral blockade of cerebellar output. 2. decerebrate ferrets were trained with ipsilateral electrical forelimb stimulation (300 ... | 1997 | 9234206 |
| further protection against antigenic drift of influenza virus in a ferret model by dna vaccination. | previously we showed that immunization of ferrets with dna encoding the hemagglutinin (ha), nucleoprotein (np), and matrix protein (m1) of influenza virus induced protective immune responses. a dna vaccine encoding ha (from a 1991 strain), np and m1 (from a 1989 strain) protected ferrets better against challenge with the antigenic drift variant a/georgia/03/93 than did the inactivated vaccine from the 1992-93 influenza season. here we report that the same dna vaccine protected ferrets against a ... | 1997 | 9234535 |
| energy metabolism in normal and hypertrophied right ventricle of the ferret heart. | using an isolated ferret heart preparation (langendorff perfusion, perfusion pressure 90 mmhg), energy metabolism has been characterized in right and left ventricles from control and hypertrophied hearts. hypertrophy was induced by pulmonary artery clipping for 30-45 days (right ventricle wall weight/body weight ratio increased by 70%). myocardial contents of high energy phosphate compounds, glycogen and lactate, and the activities of some enzymes were biochemically measured in perfused hearts a ... | 1997 | 9236144 |
| adrenal ultrasonography correlated with histopathology in ferrets. | the adrenal glands of twenty-six, 12- to 53-month-old, ferrets without clinical signs of adrenal disease were examined and measured by ultrasonography and the findings compared with those from gross examination and histopathology. of 51 adrenal glands examined, 27 were normal, 23 had either nodular or diffuse cortical hyperplasia and 1 had an adenocarcinoma. there was no statistically significant difference between the sonographic nor gross size of normal adrenal glands and those with hyperplasi ... | 2016 | 9238774 |
| scintigraphic assessment of distal extremity perfusion in 17 patients. | to assess the role of scintigraphic evaluation of distal limb perfusion, the medical records and scintigraphic perfusion images of 17 animals (8 dogs, 2 cats, 2 calves, 4 birds and 1 ferret) with clinical signs of distal limb ischemia were examined retrospectively. images were obtained at 5 and 10 minutes following injection of 99mtc-mdp, or 99mtc-dtpa. the initial scintigraphic diagnoses of 17 animals included complete ischemia (8/17), partially reduced perfusion (5/17), and normal to increased ... | 1997 | 9238793 |
| the role of helicobacter species in newly recognized gastrointestinal tract diseases of animals. | because helicobacter pylori is now known to be a significant human pathogen, experimental animal models are increasingly being used to study the pathogenesis of this organism. unfortunately, early studies failed to establish h. pylori in animal models, and surprisingly, koch's postulates were initially fulfilled in two human volunteers. germfree experiments performed in pigs and pups however established that h. pylori would colonize in these animals, and gastritis was induced. certain macaque sp ... | 1997 | 9241625 |
| comparative inotropic effect of calcium, endothelin-1, and forskolin on ferret papillary muscles during acidosis. | acidosis affects multiple steps in the excitation-contraction coupling pathway of myocardium, producing decreased calcium sensitivity of myofibrils and modification of the function of the sarcoplasmic reticulum. our aim was to evaluate the effectiveness of three different classes of inotropic agents under acidotic conditions: 1) forskolin, an adenylate cyclase activator that enhances cellular cyclic amp concentrations, 2) elevated extracellular ca2+ and 3) endothelin-1, an activator of the inosi ... | 1997 | 9243252 |
| the nk1 antagonist gr203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder. | 1. the effect of the tachykinin neurokinin1 (nk1) receptor antagonist gr203040 on cyclophosphamide (cyp)-induced bladder damage was investigated in rats and ferrets. the 5-hydroxytryptamine3 receptor antagonists ondansetron and granisetron were similarly examined in ferrets. 2. in the rat, gr203040 (10 and 30 mg/kg i.p.) reduced the cyp-induced plasma protein extravasation in the bladder by 44% and 73%, respectively (p < 0.05 and 0.005; cf. cyp controls); in the ferret, a 57% reduction (p < 0.00 ... | 1997 | 9251907 |
| inhibition of maxi-k currents in ferret portal vein smooth muscle cells by the antifungal clotrimazole. | the antifungal agent clotrimazole (clt) is a potent small-molecule inhibitor of ca-activated k (kca) currents of intermediate conductance in murine erythroleukemia cells. this study demonstrates that clt also inhibits large-conductance kca currents (maxi-k currents) in acutely dissociated vascular smooth muscle (vsm) cells of ferret portal vein. the magnitude of block of a component of the whole cell k current by clt was sensitive to test potential. clt inhibited unitary maxi-k currents in outsi ... | 1997 | 9252441 |
| flow-induced vasodilation in the ferret lung. | to examine the possibility that shear stress may be a pulmonary vasodilator stimulus, we studied the effect of changing blood flow on the diameters of small pulmonary arteries in isolated perfused ferret lung lobes. the arteries studied were in the approximately 0.3- to 1.3-mm-diameter range, and the diameters were measured by using microfocal x-ray imaging. the diameters were measured at two flow rates, 10 and 40 ml/min, with the intravascular pressure in the measured vessels the same at the tw ... | 1997 | 9262445 |
| early generation of glia in the intermediate zone of the developing cerebral cortex. | radial glia are present at the earliest stage of cerebral cortical development, and later they transform into astrocytes. other glial cells including astrocytes and oligodendrocytes are thought to appear only after neuron generation is complete and the cortical layers are formed. little is known of when and where microglia enter the central nervous system and proliferate. we addressed the question of the origin of these three glial cell types in the developing ferret cerebral cortex. we assessed ... | 1997 | 9263589 |
| retinal activity regulates developmental switches in functional properties and ifenprodil sensitivity of nmda receptors in the lateral geniculate nucleus. | previous studies have shown that marked changes occur in the kinetic properties of n-methyl-d-aspartate (nmda) receptors during development of the visual pathways. in the lateral geniculate nucleus (lgn) of the ferret, excitatory postsynaptic currents (epscs) induced by activation of nmda receptors display a very slow decay time during the first postnatal month, then become shorter in duration following eye-opening (around postnatal day 32; p32). in view of the critical role that nmda receptors ... | 1997 | 9263590 |
| biphasic emetic response of cyclophosphamide in the ferret. | cyclophosphamide (177 mg/kg, iv: n = 8) produced a biphasic emetic response in the ferret with a mean +/- se of 23.3 +/- 4.0 emetic episodes during a 4-h observation period. the emetic profile of cyclophosphamide showed a first phase with 18.6 +/- 3.9 episodes and a second phase with 4.7 +/- 1.2 episodes. ondansetron (0.07 and 0.13 mg/kg, iv) and droperidol (0.25 and 0.79 mg/kg, iv) significantly reduced the number of emetic episodes in the first phase. metoclopramide (2.24, 4.08, and 7.07 mg/kg ... | 1997 | 9264088 |
| pneumocystis carinii infection alters gtp-binding proteins in the lung. | the gtp-binding regulatory proteins (g proteins) in the membranes of the lung parenchyma from normal, uninfected ferrets were compared to those from immunosuppressed animals with and without pneumocystis carinii pneumonitis. in lung membranes, pertussis toxin (pt) catalyzed adp ribosylation of a 41-kda protein; treatment with cholera toxin (ct) led to ribosylation of a 44-kda polypeptide. compared to that in the normal ferrets, the level of the 44-kda protein was dramatically suppressed in the p ... | 1997 | 9267411 |
| in vivo characterization of gd(bme-dtta), a myocardial mri contrast agent: tissue distribution of its mri intensity enhancement, and its effect on heart function. | we have determined an ld50 of 0.56 +/- 0.05 mmol/kg for liposomal gd(bme-dtta) in mice and also shown that liposomal gd(bme-dtta) has no deleterious effects on heart rate, blood pressure, left ventricular force and av conductance in ferret hearts in vivo at the magnetic resonance imaging (mri)-effective dose of 0.05 mmol/kg body weight. in mri images, a 1h signal intensity enhancement is observed in the following organs in decreasing order of the effect: heart approximately spleen > kidney > liv ... | 1997 | 9267866 |
| species differences in the 5-hydroxytryptamine-induced contraction in the isolated distal ileum. | we investigated the mechanism of 5-hydroxytryptamine (5-ht)-induced contraction in the longitudinal muscle of isolated distal ileum from ferrets, piglets and rats. 5-ht and 5-methoxytryptamine concentration-dependently contracted the ileum of ferrets, piglets and rats. 2-methyl-5-ht and m-chlorophenylbiguanide concentration-dependently contracted the ferret ileum, whereas they had no effect in piglets and rats. in ferrets, the 5-ht-induced contraction was inhibited by methysergide and by ramoset ... | 1997 | 9268087 |
| selectivity of bms-180448 on myocardial versus brain blood flow in dogs and ferrets. | openers of adenosine triphosphate (atp)-sensitive potassium channels relax vascular smooth muscle and protect ischemic myocardium. cromakalim and bms-180448 are examples of this class of compounds. they are equipotent in their cardioprotective activity, but cromakalim and related compounds are extremely hypotensive, an activity that limits their use. the effects of cumulative i.v. doses of bms-180448 or cromakalim on hemodynamics and regional blood flow (radiolabeled microspheres) were evaluated ... | 1997 | 9268222 |
| exposure to ionizing radiation increases responsiveness to neural secretory stimuli in the ferret jejunum in vitro. | experiments were designed to determine the effects of ionizing radiation on jejunal epithelial function in the ferret in vitro. basal and stimulated electrolyte transport were determined in ussing chambers at 0.5, 2, 24 and 48 h post-irradiation. tissue histamine and 5-hydroxytryptamine levels were measured. myeloperoxidase activity was also measured as an index of inflammation. basal short circuit current was reduced at 2 h post-irradiation, but was elevated at 48 h. basal conductance was signi ... | 1997 | 9269315 |
| contribution of mitochondria to the removal of intracellular ca2+ induced by caffeine and rapid cooling at low temperatures in ferret ventricular muscles. | we investigated the role of mitochondria in the removal of intracellular ca2+ which was increased by caffeine (15 mm, caf), rapid lowering of the solution temperature from 30 to 4 degrees c (rapid cooling, rc), and electrical stimulation (0.07 hz, es). for this purpose, the intracellular ca2+ concentration ([ca2+]i) was measured using aequorin from the superficial cells of ferret papillary muscles. the three maneuvers induced transient changes in [ca2+]i with different time courses. the decay ti ... | 1997 | 9271156 |
| ca2+ release induced by rapid cooling and caffeine in ferret ventricular muscles. | the ca2+ release induced by rapid cooling (rc) and caffeine in ferret ventricular muscles was investigated. for this purpose, the author measured the intracellular ca2+ concentration ([ca2+]i) using aequorin. rapid lowering of the temperature of the bathing solution from 30 degrees c to low temperatures after the cessation of electrical stimulation transiently increased [ca2+]i. the peak of [ca2+]i was altered depending upon the temperature in rc. [ca2+]i reached 1.59 microm when the temperature ... | 1997 | 9271157 |
| effects of ruthenium red on the cellular functions and ultrastructure in intact ferret ventricular muscles. | the effects of ruthenium red (rr) on the cellular functions (intracellular ca2+ handling and contraction) and permeation of the dye through the cell membrane were investigated in intact ferret papillary muscles. the intracellular ca2+ concentration ([ca2+]i), measured using aequorin, was simultaneously recorded with tension. the permeation of the dye through the cell membrane was studied with electronmicroscopy. the preparation was continuously stimulated at 0.2 hz and treated with 50 microm rr ... | 1997 | 9271158 |
| influence of low and high frequency inputs on spike timing in visual cortical neurons. | cortical neurons in vivo respond to sensory stimuli with the generation of action potentials that can show a high degree of variability in both their number and timing with repeated presentations as wells as, on occasion, a high degree of synchronization with other cortical neurons, including in the gamma frequency range of 30-70 hz. here we examined whether or not this variability may arise from the intrinsic mechanisms of action potential generation in cortical regular spiking, fast spiking an ... | 1997 | 9276174 |
| effect of cocaine and methylecgonidine on intracellular ca2+ and myocardial contraction in cardiac myocytes. | we evaluated the cardiac effects of the principle pyrolysis product of crack cocaine smoking, methylecgonidine (meg), in comparison with cocaine. peak cell shortening and intracellular ca2+, as detected by the ca2+ indicator indo 1, were recorded in enzymatically isolated ferret myocytes. both cocaine and meg decreased peak cell shortening and peak intracellular ca2+ concentration ([ca2+]i) in a dose-dependent manner (10(-8)-10(-4) m). meg shifted the peak [ca2+]i-to-peak shortening relationship ... | 1997 | 9277508 |
| evaluation of the sedative and cardiorespiratory effects of medetomidine, medetomidine-butorphanol, medetomidine-ketamine, and medetomidine-butorphanol-ketamine in ferrets. | ten ferrets were used in a crossover study to determine the anesthetic effects of intramuscular (i.m.) medetomidine (80 microg/kg body weight), medetomidine (80 microg/kg body weight)-butorphanol (0.1 mg/kg body weight), medetomidine (80 microg/kg body weight)-ketamine (5 mg/kg body weight), and medetomidine (80 microg/kg body weight)-butorphanol (0.1 mg/kg body weight)-ketamine (5 mg/kg body weight). all ferrets assumed lateral recumbency within four minutes and remained dorsally recumbent for ... | 2013 | 9278121 |
| the monoclonal antibody h386f labels microglia in the retinal nerve fiber layer of several mammals. | the antibody h386f revealed microglia in the retinae of several species: owl monkey, slow loris, galago, ferret, raccoon, and tree shrew. the shape, size, and density of labeled microglia were identical to those labeled by ox-42 and ox-41, two antibodies specific for microglia, in both galago and owl monkey. the labeled microglia varied little in retinal location. there was remarkably little variability in density, shape, number, and size of the labeled microglia between species. all labeled mic ... | 1997 | 9278995 |
| estimation of thickness of airway surface liquid in ferret trachea in vitro. | the tracheae of ferrets and rabbits were mounted in vitro in organ baths. while the tracheae were liquid filled, the permeability coefficient ( p) was determined, and then while the tracheae were air filled, the percent clearance for 99mtc-labeled diethylenetriaminepentaacetic acid (dtpa) was determined. the thickness of airway surface liquid (asl) was estimated by three methods. 1) the initial concentration of 99mtc-dtpa and the total amount of 99mtc-dtpa (the sum of that entering the outside m ... | 1997 | 9292461 |
| nitrogen balance in adult female mink (mustela vision) in response to normal feeding and short-term fasting. | ten adult female mink (mustela vison) were studied in a 7 d balance experiment consisting of a 2 d pre-surgery feeding period, followed by surgery, 1 d of recovery 4 d of ad libitum feeding, and a 2 d fasting period. in this experiment (expt a) the animals had osmotic pumps implanted for continuous release of radioactively-labelled p-aminohippuric acid (p-aminobenzoyl-2-[3h]glycine; [3h]pah; n 10) and 14c-labelled inulin ([14c]in; n 5). repeated 24 h collections of urine, corrected to 100% [3h]p ... | 1997 | 9292762 |
| identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes. | the inositol 1,4,5-trisphosphate receptor (insp3r) is an intracellular ca2+ release channel that mediates the rise in cytoplasmic calcium in response to receptor-activated production of insp3. the insp3r-mediated signaling pathway appears to be ubiquitous and is involved in many cellular processes including cell division, smooth muscle contraction, and neuronal signaling. different regions of the heart also express insp3 receptors. we report here that acutely dissociated ventricular myocytes fro ... | 1997 | 9295347 |
| bioenergetic characteristics of the costal and crural diaphragm in mammals. | these experiments compared oxidative and glycolytic enzyme activity in the costal and crural diaphragm in seven adult mammals (mouse, rat, rabbit, ferret, sheep, pig, cow) ranging in body mass from approximately 0.03 to 422 kg. segments of the costal and crural diaphragm from the aforementioned species were homogenized to determine the activities of the glycolytic enzyme, lactate dehydrogenase (ldh), and the krebs cycle enzyme, citrate synthase (cs). the results indicated that metabolic differen ... | 1997 | 9299646 |
| negative inotropic effect of methylecgonidine, a major product of cocaine base pyrolysis, on ferret and human myocardium. | this study examined the physiological effects and potential mechanisms of action of methylecgonidine (meg), the major pyrolysis product from smoking "crack cocaine," on cardiac function. ferret right ventricular papillary muscles and human ventricular trabeculae were isolated and placed in a physiological solution at 30 degrees c containing 2.5 mm ca2+ and stimulated at 0.33 hz. meg decreased peak tension and peak intracellular ca2+ transients in a concentration-dependent manner (10 microm-1 mm) ... | 1997 | 9300320 |
| mdl-28170, a membrane-permeant calpain inhibitor, attenuates stunning and pkc epsilon proteolysis in reperfused ferret hearts. | this paper tests the hypothesis that calpains are activated in the ischemic (i)/reperfused (r) heart and contribute to myocardial stunning. | 1997 | 9302348 |
| brain-derived neurotrophic factor/neurotrophin-4 receptor trkb is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina. | the tyrosine kinase trkb is a receptor for the neurotrophic factors brain-derived neurotrophic factor (bdnf) and neurotrophin-4 (nt-4). retinal ganglion cells are responsive to bdnf, and trkb has been localized in ganglion cells as well as in a subpopulation of amacrine cells in the retina of the chicken and the rat. in the present paper, we analyzed the distribution of trkb immunoreactivity in the retina of marmoset monkeys, ferrets, rabbits, rats, mice, chickens, pigeons, barn owls, pseudemys ... | 1997 | 9303531 |
| purification and partial characterization of a cellular carotenoid-binding protein from ferret liver. | a cellular carotenoid-binding protein was purified to homogeneity from beta-carotene-fed ferret liver utilizing the following steps: ammonium sulfate precipitation, ion exchange, gel filtration, and affinity chromatography. the final purification was 607-fold. [14c]beta-carotene co-purified with the binding protein throughout the purification procedures. sds-page of the purified protein showed a single band with an apparent molecular mass of 67 kda. scatchard analysis of the specific binding of ... | 1997 | 9305906 |
| response properties of neurons in the inferior colliculus of the monaurally deafened ferret to acoustic stimulation of the intact ear. | response properties of neurons in the central nucleus of the inferior colliculus (icc) were investigated after unilateral cochlear removal at various ages during infancy. nineteen ferrets had the right cochlea surgically ablated, either in adulthood or on postnatal day (p) 5, 25, or 40, 3-18 mo before recording. adult ablations were made on the same day as ("acute," n = 3), or 2-3 mo before ("chronic," n = 3), recording. two ferrets were left binaurally intact. single-unit (n = 702) and multiuni ... | 1997 | 9307111 |
| functional dynamics of gabaergic inhibition in the thalamus. | the inhibitory gamma-aminobutyric acid-containing (gabaergic) neurons of the thalamic reticular and perigeniculate nuclei are involved in the generation of normal and abnormal synchronized activity in thalamocortical networks. an important factor controlling the generation of activity in this system is the amplitude and duration of inhibitory postsynaptic potentials (ipsps) in thalamocortical cells, which depend on the pattern of activity generated in thalamic reticular and perigeniculate cells. ... | 1997 | 9311919 |
| calponin and mitogen-activated protein kinase signaling in differentiated vascular smooth muscle. | contraction of smooth muscle cells is generally assumed to require ca2+/calmodulin-dependent phosphorylation of the 20-kda myosin light chains. however, we report here that in the absence of extracellular calcium, phenylephrine induces a contraction of freshly isolated ferret aorta cells in the absence of increases in intracellular ionized calcium or light chain phosphorylation levels but in the presence of activation of mitogen-activated protein kinase. a protein at 36 kda co-immunoprecipitated ... | 1997 | 9312127 |
| enhanced ca2+ current and decreased ca2+ efflux restore sarcoplasmic reticulum ca2+ content after depletion. | [ca2+]i was measured using the fluorescent indicator indo 1 in voltage-clamped ferret and rat ventricular myocytes. the ca2+ content of the sarcoplasmic reticulum (sr) was estimated from the integral of the na(+)-ca2+ exchange current activated by caffeine. refilling of the sr after caffeine removal was enhanced by stimulation. as the systolic ca2+ transient recovered, the integral of the l-type ca2+ current decreased and that of the na(+)-ca2+ exchange tail current increased. for the early puls ... | 1997 | 9314828 |
| proposal for the interaction of non-conventional partial agonists and catecholamines with the 'putative beta 4-adrenoceptor' in mammalian heart. | 1. evidence for a 'putative beta 4-adrenoceptor' originated over 20 years ago when cardiostimulant effects were observed to non-conventional partial agonists. these agonists were originally described as beta 1- and beta 2-adrenoceptor antagonists; however, they cause cardiostimulant effects at much higher concentrations than those required to block beta 1- and beta 2-adrenoceptors. cardiostimulant effects of non-conventional partial agonists have been observed in mouse, rat, guinea-pig, cat, fer ... | 1997 | 9315364 |
| length dependence of ca(2+)-tension relationship in aequorin-injected ferret papillary muscles. | the possible contractile proteins, which are related to the length-dependent change in the relationship between intracellular ca2+ concentration ([ca2+]i) and tension, were investigated using aequorin-injected ferret papillary muscles. tetanic contraction was produced by applying repetitive stimulation to the ryanodine-treated preparations, and the relationships between [ca2+]i and tension were measured. when the muscle length was decreased from maximal length (lmax), at which maximal tension is ... | 1997 | 9321790 |
| evaluation of noninvasive monitoring techniques in domestic ferrets (mustela putorius furo). | to evaluate instrument placement and accuracy of indirect physiologic monitoring techniques in anesthetized domestic ferrets. | 1997 | 9328655 |
| identification and quantification of retinoic acid and other metabolites from beta-carotene excentric cleavage in human intestine in vitro and ferret intestine in vivo. | 1997 | 9330282 | |
| nitric oxide in the control of submandibular gland function in the anaesthetized ferret. | stimulation of parasympathetic innervation of the submandibular gland (2 or 20 hz continuously or 20 hz for 1 s at 10 s intervals), in the ferret, produced secretion of fluid and protein and a fall in vascular resistance. the responses following the administration of n omega-nitro-l-arginine methyl ester (l-name; 2 mmol kg-1 i.a.) to block the synthesis of nitric oxide (no) were reduced, and the persisting responses were abolished (at 2 hz continuously and 20 hz intermittently) or further reduce ... | 1997 | 9331552 |
| developmental changes in regulation of the na+, k(+)-atpase alpha 3 isoform by thyroid hormone in ferret heart. | ferret heart expresses the alpha 1- as well as the alpha 3-isoform of the na+, k(+)-atpase. we have shown previously that the alpha 3 isoform is differentially upregulated during postnatal cardiac development and that in adult ferrets expression of alpha 3 is not responsive to regulation by thyroid hormone (th). since developmental-stage dependent effects of th have been reported previously, the present study examined whether effects of th on expression of the na+, k(+)-atpase isoforms in ferret ... | 1997 | 9332453 |
| modulation of intrinsic circuits by serotonin 5-ht3 receptors in developing ferret visual cortex. | serotonergic projections are widespread in the developing neocortex, but their functions are obscure. the effects of 5-ht3 receptor agonists on cortical circuit response properties were studied in slices of ferret primary visual cortex using high-speed optical imaging of voltage-sensitive dye signals and whole-cell patch-clamp recording. activation of the 5-ht3 receptor decreased the amplitude and lateral extent of excitation throughout postnatal development. this effect peaks after eye opening, ... | 1997 | 9334407 |
| fast synaptic signaling by nicotinic acetylcholine and serotonin 5-ht3 receptors in developing visual cortex. | cholinergic and serotonergic fiber systems invade the developing visual cortex several weeks before eye opening; both transmitters have been implicated in plasticity of neocortical circuits. these transmitters have been presumed to act predominantly through second messenger-coupled receptors, because fast cholinergic or serotonergic neurotransmission has never been observed in neocortex. however, acetylcholine and serotonin also act on ligand-gated ion channels; the nicotinic acetylcholine recep ... | 1997 | 9334409 |
| activity-dependent regulation of nmdar1 immunoreactivity in the developing visual cortex. | nmda receptors have been implicated in activity-dependent synaptic plasticity in the developing visual cortex. we examined the distribution of immunocytochemically detectable nmdar1 in visual cortex of cats and ferrets from late embryonic ages to adulthood. cortical neurons are initially highly immunostained. this level declines gradually over development, with the notable exception of cortical layers 2/3, where levels of nmdar1 immunostaining remain high into adulthood. within layer 4, the decl ... | 1997 | 9334411 |
| optically imaged maps of orientation preference in primary visual cortex of cats and ferrets. | feature maps in the cerebral cortex constitute orderly representations of response features created within the cortex; an example is the mapping of orientation-selective neurons in visual cortex. we have compared the properties of orientation maps in area 17 of cats and ferrets, obtained by optical imaging of intrinsic signals. orientation maps in both species contain a quasi-periodic distribution of iso-orientation domains that are organized into a lattice of pinwheels. however, the spatial den ... | 1997 | 9335420 |
| histogenesis of ferret somatosensory cortex. | the ferret has emerged as an important animal model for the study of neocortical development. although detailed studies of the birthdates of neurons populating the ferret visual cortex are available, the birthdates of neurons that reside in somatosensory cortex have not been determined. the current study used bromodeoxyuridine to establish when neurons inhabiting the somatosensory cortex are generated in the ferret; some animals also received injections of [3h]thymidine. in contrast to reports o ... | 1997 | 9336222 |
| pyloric motor response to central and peripheral nitric oxide in the ferret. | this study has investigated the relative importance of central nervous and peripheral nitroxidergic mechanisms in the control of pyloric motility. in 10 urethane-anaesthetized ferrets, drugs were administered directly to the cns via a 0.5-mm-diameter cannula inserted into the 4th ventricle, approximately at the obex. drugs were also given directly to the upper gi tract by close intra-arterial (i.a.) injection at the coeliac axis. antropyloroduodenal pressures were recorded with a five-channel sl ... | 1997 | 9347472 |
| callosal connections of the ferret primary auditory cortex. | the callosal connections of ferret auditory cortex were studied by making multiple injections of wheat germ agglutinin-horseradish peroxidase into the middle ectosylvian gyrus or by packing crystals of horseradish peroxidase into the transected corpus callosum. the primary area (ai) had strong callosal connections that arose from somata mainly located in layer iii. other layers contained sparsely distributed cells that projected across the midline. the projecting cells occurred over the whole ex ... | 1997 | 9348135 |
| brain region-specific regulation of luteinizing hormone-releasing hormone messenger ribonucleic acid in the male ferret: interactions between pubertal maturation and testosterone. | this study examined the regulation of lhrh messenger rna (mrna) during pubertal maturation and by testosterone in male ferrets. prepubertal and postpubertal ferrets were either intact or were castrated and treated with daily injections of oil or 5 mg/kg testosterone propionate for 14 days. in situ hybridization for lhrh mrna was performed using an 35s-labeled 48-base oligonucleotide complementary to the human lhrh-coding region. computerized image analysis was performed on cells in the preoptic ... | 1997 | 9348201 |
| functional properties of perigeniculate inhibition of dorsal lateral geniculate nucleus thalamocortical neurons in vitro. | the properties of the inhibitory influence of neurons in the perigeniculate (pgn) nucleus on thalamocortical cells were examined with intracellular recordings in the ferret geniculate slice maintained in vitro. activation of pgn neurons with the local application of glutamate caused ipsps in thalamocortical neurons that were mediated by both gabaa and gabab receptors, as well as the activation of spindle waves. with low intensity stimulation of the pgn, local application of bicuculline to the do ... | 1997 | 9348355 |