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electroporation of helicobacter pylori. 19957550733
effects of helicobacter pylori infection on gastric mucosal defense factors in japanese monkeys.the pathogenic role played by helicobacter pylori in gastric mucosal defense was investigated in japanese monkeys infected with h. pylori. serum gastrin levels and ammonia concentrations in gastric juice were compared in h. pylori-infected (n = 6) and control (n = 7) groups. the gastritis score, the intracellular content of periodic acid-schiff (pas)-positive substance and hexosamine, and the bromodeoxyuridine (brdu) labeling index in the gastric mucosa were compared in the two groups in the ant ...19957550852
a proton pump inhibitor, e3810, has antibacterial activity through binding to helicobacter pylori.helicobacter pylori infection is causally related to atrophic gastritis, and it may also be associated with peptic ulcer and gastric carcinoma. eradication of h.pylori is recommended in patients with such diseases, especially in those with peptic ulcer. a new potent proton pump inhibitor, e3810, had an antibacterial effect on h. pylori, as has been reported for omeprazole and lansoprazole, two other proton pump inhibitors. the minimum inhibitory concentration of e3810 was 1.57-3.13 micrograms/ml ...19957550855
drug therapy of peptic ulcer disease.healing of peptic ulcers can be achieved by using a variety of anti-ulcer medications. the most commonly used agents include the histamine-2 receptor antagonists (h2ras) and the proton pump inhibitors. they are also efficacious in preventing ulcer recurrence providing maintenance treatment is given. the ideal treatment for peptic ulcers today is aiming at eradication of helicobacter pylori infection. successful elimination of the latter not only heals the ulcers but also provides a cure for the ...19957551483
gastric juice epidermal growth factor concentration and helicobacter pylori in patients with duodenal ulcer.the level of epidermal growth factor (egf) was measured in the basal and maximally stimulated gastric juice of 20 control subjects and 20 patients each with duodenal ulcer and non-ulcer dyspepsia. basal gastric juice was analysed for ammonia and urea concentrations, and the [ammonia]3/[urea] ratio was used to show helicobacter pylori status, as was the [13c]urea breath test in nine controls. there was complete concordance in the nine controls between the two methods for determining h. pylori sta ...19957551996
helicobacter pylori: who is positive and who is not? 19957552635
adhesion molecule expression on gastric intra-epithelial lymphocytes of patients with helicobacter pylori infection.to examine the expression of adhesion molecules on gastric intra-epithelial lymphocytes (iels) from patients infected with helicobacter pylori.19957552637
helicobacter pylori and gastric cancer. 19957552645
eczema responsive to treatment for helicobacter pylori. 19957552934
influence of amoxicillin, erythromycin and metronidazole on adherence of helicobacter pylori. 19957553363
metronidazole uptake in helicobacter pylori.currently, the mechanism of metronidazole resistance is not understood in helicobacter pylori. we have looked at uptake of metronidazole into a sensitive and a resistant strain of h. pylori. both strains displayed rapid uptake of [14c]metronidazole, although the resistant strain accumulated the drug at a slower rate and to a lesser amount than the sensitive strain. uptake was inhibited by kcn and carbonyl cyanide m-chlorophenyl-hydrazone (cccp) but not by sodium arsenate. thin-layer chromatograp ...19957553456
determination of the test performance of less costly methods of helicobacter pylori detection.since helicobacter pylori (hp) has become so important in the management of peptic ulcers, it is imperative that noninvasive and inexpensive methods of diagnosis be available. the objective of this prospective, double-blind study was to determine the performance of the noninvasive 14c-urea breath test and the less expensive hematoxylin-phloxin-saffron (hps) and giemsa stains in the detection of this infection. as well, we set out to determine the minimal number of biopsies required to make an ac ...19957554584
healing of gastric body ulcer with gastroprotective versus antisecretory treatment.the aim of this study was to compare the healing effect of a gastroprotective agent and antisecretory drugs in gastric body ulcer where failure of the mucosal defense might be an important factor. eighty-five patients with benign gastric ulcer were divided into four groups: treated with antacids (i), cimetidine (ii), ranitidine (iii), and colloidal bismuth subcitrate (de-nol) (iv). endoscopically confirmed complete healing was achieved in 57, 61, and 63% in groups i, ii, and iii, respectively, a ...19957555458
severe gastric mucosal damage induced by nsaids in healthy subjects is associated with helicobacter pylori infection and high levels of serum pepsinogens.helicobacter pylori infection and nsaids are considered the two most important exogenous factors in ulcer disease. the interrelation between the two factors is not, however, clear. moreover, serum pepsinogen has been suggested as a risk marker for the development of nsaid-induced gastrointestinal lesions. fifty-one healthy volunteers, enrolled in a prospective, double-blind study carried out to evaluate gastrointestinal side effects of meloxicam and piroxicam, were analyzed to determine whether: ...19957555467
[combined therapy with azithromycin and omeprazole for the eradication of helicobacter pylori]. 19957555645
antibacterial properties of lansoprazole alone and in combination with antimicrobial agents against helicobacter pylori.the activities of various types of antiulcer agents against helicobacter pylori strains were determined by an agar dilution method. among the compounds tested, benzimidazole proton pump inhibitors were found to have significant activity against this organism. the activity of lansoprazole was fourfold more potent than that of omeprazole and bismuth subsalicylate, with mics ranging from 1.56 to 25 micrograms/ml. exposure of helicobacter pylori to lansoprazole led to an extensive loss of viability ...19957556227
multi-laboratory comparison of eight commercially available helicobacter pylori serology kits. helicobacter pylori serology study group.the performance of eight commercially available eia kits in detecting antibody to helicobacter pylori was evaluated by a panel of 17 laboratories using serum from 59 patients selected from endoscopy clinics in belgium, ireland, italy, the netherlands and switzerland. each laboratory received a randomly numbered set of sera and was ignorant of the culture results of the patients. the performance of the kits was assessed in terms of diagnostic accuracy compared to culture (measured by sensitivity ...19957556232
risk factors associated with refractory peptic ulcers.the risk factors associated with refractory peptic ulcers are still undefined. the purpose of this study was to identify these factors in a multivariate context.19957557077
expression, processing, and secretion of gastrin in patients with colorectal carcinoma.the relationship between gastrin and the development of colorectal carcinoma (crc) remains controversial. problems with previous studies include failure to measure all forms of gastrin, lack of comparison between stored and secreted gastrin, and not controlling for helicobacter pylori infection (a known cause of hypergastrinemia). the aim of this study was to quantify progastrin and progastrin-derived peptides in the resected tumor and plasma of patients with crc and in the antrum and plasma of ...19957557079
effect of longterm misoprostol coadministration with non-steroidal anti-inflammatory drugs: a histological study.prostaglandins are widely used in the prevention and healing of non-steroidal anti-inflammatory drug (nsaid) induced gastric and duodenal ulcers, but their longterm effect on the human gastric mucosa is unknown. this study assessed the effect of coadministration of prostaglandins with nsaids on the histology of the gastroduodenal mucosa. histological appearances (using the sydney system) of gastric biopsy specimens from 180 patients receiving longterm nsaid treatment of whom 90 had been receivin ...19957557567
seroepidemiology of gastritis in japanese and dutch working populations: evidence for the development of atrophic gastritis that is not related to helicobacter pylori.serological markers of gastritis, like pepsinogen a, pepsinogen c, gastrin, and helicobacter pylori antibodies, can be used to explore the state of the gastric mucosa in populations with contrasting cancer risks. a decreasing pepsinogen a:c ratio and an increasing serum gastrin are known to reflect an increasing severity of atrophic corpus gastritis, which is a precursor of gastric cancer. in 723 subjects (without gastroduodenal surgery) from japanese (n = 225) and dutch (n = 498) working popula ...19957557568
behaviour of acid secretion, gastrin release, serum pepsinogen i, and gastric emptying of liquids over six months from eradication of helicobacter pylori in duodenal ulcer patients. a controlled study.the behaviour of basal and stimulated acid secretion, gastrin release, serum pepsinogen i, and gastric emptying of liquids was studied in 19 consecutive patients with helicobacter pylori positive duodenal ulcer, over a follow up period of six months. eleven patients were studied before and at three and six months after eradication with lansoprazole plus amoxicillin and tinidazole (case group), whereas the remainder, with persistent h pylori infection, were studied before and after three and six ...19957557570
effect of helicobacter pylori on the gastric mucus gel. 19957557586
[helicobacter pylori as a cause of benign malignant peptic ulcer]. 19957557697
colloid bismuth versus famotidine in the treatment and prevention of duodenal ulcer relapse: results of a double-blind, double dummy randomized study.fifty-three consecutive patients with active duodenal ulcer (du) were randomly included in a double-blind, double-dummy study to test the healing and relapsing rate of two treatment regimens: famotidine 40 mg nocte for 4-8 weeks, followed by 20 mg for 12 months after healing of the ulcer and colloidal bismuth (cbs) (240 mg bid) for 4-8 weeks, followed by placebo maintenance treatment. the results of the short term period confirmed the efficacy of cbs in healing du (24/25 in cbs group and 19/23 i ...19957557824
role of the helicobacter pylori virulence factors vacuolating cytotoxin, caga, and urease in a mouse model of disease.the pathogenic role of helicobacter pylori virulence factors has been studied with a mouse model of gastric disease. balb/c mice were treated orally with different amounts of sonic extracts of cytotoxic h. pylori strains (nctc 11637, 60190, 84-183, and 87a300 [caga+/tox+]). the pathological effects on histological sections of gastric mucosae were assessed and were compared with the effects of treatments with extracts from noncytotoxic strains (g21 and g50 [caga-/tox-]) and from strains that expr ...19957558333
iron-repressible outer membrane proteins of helicobacter pylori involved in heme uptake.helicobacter pylori is known to be a causative agent of gastritis and peptic ulcer disease in humans. the acquisition of iron from the human host may contribute greatly to the virulence of this organism. to study this, h. pylori was cultured under iron-restrictive conditions to induce synthesis of possible iron-regulated outer membrane proteins. this was achieved by the addition of 20% (vol/vol) heat-inactivated newborn calf serum, which contains iron-binding proteins like transferrin and albumi ...19957558334
redox potential and oxygen concentration as factors in the susceptibility of helicobacter pylori to nitroheterocyclic drugs.metronidazole sensitive (mtzs) and resistant (mtzr) strains of helicobacter pylori were tested for their sensitivities to eleven nitroheterocyclic drugs of known reduction potential under a wide range of environmental conditions. under microaerophilic conditions, mtzr strains were sensitive to all the 2-nitroimidazoles, resistant to every 5-nitroimidazole, and slightly sensitive to the nitrothiazole, niridazole. mtzs strains were sensitive to all the nitroimidazoles except for 4(5)-nitroimidazol ...19957559187
isolation and characterization of a conserved porin protein from helicobacter pylori.helicobacter pylori is a causative agent of gastritis in humans and is correlated with gastric ulcer formation. infections with this bacterium have proven difficult to treat with antimicrobial agents. to better understand how this bacterium transports compounds such as antimicrobial agents across its outer membrane, identification of porin proteins is important. we have recently identified a family of h. pylori porins (hopa to hopd) (m. m. exner, p. doig, t. j. trust, and r. e. w. hancock, infec ...19957559328
[helicobacter pylori infection in peptic ulcer and gastric cancer diseases]. 19957559919
immunomagnetic separation and pcr for detection of helicobacter pylori in water and stool specimens.the detection of helicobacter pylori in clinical and environmental samples by pcr sometimes requires removal of polymerase inhibitors. we have used a magnetic immunoseparation technique as pre-pcr treatment to facilitate direct detection of h. pylori in stool and water specimens. rabbit hyperimmune antiserum was produced and magnetic beads were coated with purified immunoglobulin g, which reacted with and bound to both coccoid and rod-shaped forms of h. pylori. when pcr was applied for the detec ...19957559969
high prevalence of helicobacter pylori in saliva demonstrated by a novel pcr assay.to investigate the prevalence of helicobacter pylori in the saliva of patients infected with this bacterium.19957560176
comparison of agar based media for primary isolation of helicobacter pylori.to determine the best medium for the primary isolation of helicobacter pylori.19957560195
helicobacter pylori and gastrointestinal disease.new paradigms are few and far between. the discovery that peptic ulcer disease is the result of an infection by a previously unrecognized microorganism rather than the consequence of excess secretion of gastric acid aptly qualifies as a paradigm shift. eradication of helicobacter pylori from the stomach by antibacterial agents heals ulcers at least as effectively as h2-blockers. further, eradication of the organism results in long-term cures of peptic ulcers. in contrast, the relapse rate in pat ...19957560243
helicobacter pylori infection and foreign travel.seroprevalence of antibodies to helicobacter pylori is generally higher in developing than in developed countries. the route of transmission of h. pylori is unknown but is most commonly assumed to be fecal-oral. gastroenteritis in a person traveling to developing countries is often a marker of exposure to fecally contaminated food or water. of 133 initially seronegative young swedes traveling to developing countries for a total of 16.4 years, of whom 102 reported having had at least one episode ...19957561197
helicobacter pylori seroprevalence and colorectal neoplasia: evidence against an association. 19957563155
the 1995 albert lasker medical research award. helicobacter pylori. the etiologic agent for peptic ulcer. 19957563460
hyperammonaemia in cirrhosis and helicobacter pylori infection. 19957564815
helicobacter pylori and gastric neoplasia: evolving concepts.there is evidence that helicobacter pylori infection is associated with gastric cancer and mucosa-associated lymphoid tissue (malt) lymphoma and possibly with non-ulcer dyspepsia. eradication therapy for confirmed h. pylori infection may therefore become mandatory in patients with non-ulcer dyspepsia severe enough to warrant endoscopy and in first-degree relatives of patients with gastric cancer. however, routine treatment of asymptomatic carriers awaits confirmation of the association with canc ...19957565211
helicobacter pylori: how often are eradication therapies prescribed? 19957565248
molecular biology of microbial ureases.urease (urea amidohydrolase; ec 3.5.1.5) catalyzes the hydrolysis of urea to yield ammonia and carbamate. the latter compound spontaneously decomposes to yield another molecule of ammonia and carbonic acid. the urease phenotype is widely distributed across the bacterial kingdom, and the gene clusters encoding this enzyme have been cloned from numerous bacterial species. the complete nucleotide sequence, ranging from 5.15 to 6.45 kb, has been determined for five species including bacillus sp. str ...19957565414
the economic and quality-of-life benefits of helicobacter pylori eradication in chronic duodenal ulcer disease--a community-based study.a policy of helicobacter pylori eradication in patients with duodenal ulceration on long-term acid-suppressing therapy was evaluated in a prospective study amongst a general practice population, with particular reference to economic and quality-of-life benefits. one hundred and sixty-eight patients on long-term acid-suppressing therapy had chronic duodenal ulcer disease of whom 88 were eligible for the study; 45 patients attended for review, with 42 testing positive for h pylori (as assessed by ...19957567733
[presence of helicobacter pylori in the duodenum, antrum, and fundus in control subjects and patients with duodenal ulcer, gastric ulcer, gastritis, or erosive duodenitis. histological analysis of 357 subjects].the prevalence of helicobacter pylori infection was studied in 152 subjects with a normal upper gastrointestinal endoscopy, 125 with duodenal ulcer, 25 with gastric ulcer, 46 with erosive gastritis and 9 with erosive duodenitis. two biopsies from duodenum, antrum and fundus were obtained from each subject during endoscopy for histological diagnosis and helicobacter pylori search. none of the patients with normal endoscopy and 2% of patients with duodenal ulcers had helicobacter pylori in duodena ...19957569457
[comparison of 2 treatment schemes to eradicate helicobacter pylori].anti secretory drugs, antimicrobials and bismuth salts are used with variable success to eradicate helicobacter pylori.19957569458
helicobacter pylori-associated gastritis. evolution of histologic changes over 10 years.helicobacter pylori seems to be the commonest cause of chronic gastritis, but the natural course of h. pylori-associated gastritis is largely obscure.19957569761
helicobacter pylori infection is associated with low antral somatostatin content in young adults. implications for the pathogenesis of hypergastrinemia.recent studies on the role of helicobacter pylori in the pathogenesis of duodenal ulcers have focused on the mechanism by which h. pylori infections cause exaggerated gastrin release.19957569762
gastroduodenal diseases on the jos plateau, nigeria.two hundred and forty-three nigerian patients referred for endoscopy at the jos university teaching hospital in nigeria were studied. their overall mean age was 37.7 years (sd 12.7), among those with ulcers it was 38.4 years. the male:female ratio was equal in general, but among those with ulcers it was 2:1. duodenal and gastric ulcers were found in 42(17.3%) and 12(4.9%) patients respectively, ratio of 3.5:1. there were 3 patients each with oesophageal and gastric carcinoma. our findings do not ...19947570821
royal society of tropical medicine and hygiene meeting at manson house, london, 16 february 1995. aspects of helicobacter pylori infection in the developing and developed world. helicobacter pylori infection, nutrition and growth of west african infants.helicobacter pylori is probably the commonest bacterial infection of humankind. in adults, colonization of the stomach is associated with chronic gastritis and duodenal ulcer disease. however, children in the developing world acquire h. pylori soon after birth, and there is evidence that it plays a part, through suppression of the gastric acid barrier, in the pathogenesis of the syndrome of diarrhoea, malnutrition and growth failure. infants born of mothers who secrete milk with high levels of a ...19957570858
helicobacter pylori: i. ultrastructural sequences of adherence, attachment, and penetration into the gastric mucosa.new ultrastructural observations on the sequences of adherence, attachment, and penetration of helicobacter pylori (hp) into the gastric epithelium were described in 32 endoscopic biopsies selected randomly from 168 samples of patients with active chronic gastritis. the adherence of hp to the target cell was initiated by direct contact with the microvillar coat, or glycocalyx, leading to the loss of that coat. the next step was demolishing of the surface microvilli, which separate the organisms ...19957571091
[antibacterial treatment of gastric ulcers associated with helicobacter pylori without acid suppression]. 19957571762
cytologic brushing as a simple and rapid method in the diagnosis of helicobacter pylori infection.to assess broad antral cytologic brushing as an alternative approach for the diagnosis of helicobacter pylori gastric colonization as compared to histology.19957571970
gastric carcinoma: the helicobacter pylori trail.gastric carcinoma is the world's overall second most common cancer. besides obvious environmental factors, recent epidemiological studies and a better knowledge of helicobacter pylori biological properties revealed that the microorganism is involved in the first steps of gastric carcinogenesis as proposed by the correa model (from normal gastric tissue through superficial gastritis, multifocal atrophic gastritis, intestinal metaplasia and dysplasia to carcinoma). significant correlation between ...19957571979
are perforated gastroduodenal ulcers related to helicobacter pylori infection?the prevalence of helicobacter pylori gastritis in 36 patients with a perforated ulcer undergoing endoscopy prior to or at least 2 months after perforation was 56%, intermediate between that of age and sex matched healthy blood donors (36%) who had measurement of circulating antibodies to helicobacter pylori and of ulcer patients without perforation matched for age, sex and ulcer location (86%). in the 20 patients with helicobacter pylori gastritis, 8 had a history of peptic ulcer and 7 of 9 pat ...19957571981
lymphocytic gastritis. clinical and endoscopic presentation and long-term follow-up.lymphocytic gastritis is a histopathological entity corresponding with diffuse varioliform gastritis but also with other gastroscopic findings. eighteen patients were followed over a mean period of 25 months. the symptoms, the endoscopic and histopathological abnormalities remained unchanged in the majority of the cases. conventional peptic ulcer therapy failed to control symptoms or to normalize endoscopic alterations. helicobacter pylori did not seem to play a role in the pathophysiology. lymp ...19957571985
seroepidemiologic study of helicobacter pylori infection in children in taipei city.to study the epidemiology of helicobacter pylori (h. pylori) infection in children, the presence of the igg antibody against h. pylori was evaluated by enzyme-linked immunosorbent assay (elisa) method in unselected children in taipei city. serum samples were collected there from 428 apparently healthy children under 12 years of age. the overall prevalence of h. pylori infection was 8.4%. a low prevalence was found in the groups 1-3 years old (0.9%) and 3-6 years old (3.7%). the prevalence rate i ...19957572166
salivary-specific immunoglobulin g in the diagnosis of helicobacter pylori infection in dyspeptic patients.helicobacter pylori infection is arguably the most common chronic bacterial infection in humans. the high prevalence and the association with peptic ulceration and gastric cancer indicate that simple, noninvasive methods for diagnosis of the infection are needed. in this study, the accuracy of salivary diagnosis for h. pylori infection was assessed.19957572901
the effects of short-term lansoprazole therapy on helicobacter pylori infection and antral gastritis in duodenal ulcer patients.lansoprazole is a new potent proton pump inhibitor that exhibits activity against helicobacter pylori in vitro. this study endeavored to determine the effects of 4 wk of lansoprazole therapy upon h. pylori infection and antral gastritis in duodenal ulcer patients and to determine the relationship of the gastritis with helicobacter infection and with ulcer activity.19957572902
electron microscopic study of association between coccoid forms of helicobacter pylori and gastric epithelial cells.to investigate the relationship between helical and coccoid forms of helicobacter pylori and gastric epithelial cells.19957572903
low prevalence of helicobacter pylori in inflammatory bowel disease: association with sulfasalazine. 19957572928
do helicobacter pylori-positive duodenal ulcers have an increased risk of bleeding? 19957572929
biologic sex as a risk factor for helicobacter pylori infection in healthy young adults.diseases associated with helicobacter pylori infection, such as peptic ulcer disease and gastric cancer, afflict men more frequently than women. no study, however, has demonstrated any difference in sex-specific rates of h. pylori infection. in a healthy population undergoing multiphasic health evaluations in 1992-1993 as members of the kaiser permanente medical care program of northern california, adults aged 20-39 years were screened for antibodies to h. pylori infection using a serum enzyme-l ...19957572962
a cost analysis of alternative treatments for duodenal ulcer.to compare the costs of alternative strategies for the treatment of duodenal ulcer.19957574221
bacterial activity of a new antiulcer agent, ecabet sodium, against helicobacter pylori under acidic conditions.helicobacter pylori nctc 11637, which is nonviable at ph 3.0, became viable after addition of 10 mm urea owing to ammonia production by urease. in a buffer supplemented with urea, ecabet sodium decreased both the production of ammonia and the number of viable cells of h. pylori nctc 11637 and changed the bacteria from the bacilliform to the horseshoe or doughnut shape in a concentration-dependent manner. in particular, ecabet sodium (2 and 4 mg/ml) decreased the number of viable cells below the ...19957574519
oxidative metabolism in nonculturable helicobacter pylori and vibrio vulnificus cells studied by substrate-enhanced tetrazolium reduction and digital image processing.growing and nonculturable cells of helicobacter pylori and vibrio vulnificus were studied for the capacity to reduce tetrazolium salts in order to elucidate the possible physiological basis for the proposed "viable but nonculturable" (vnc) state. initial difficulties in obtaining consistent reduction of rho-iodonitrotetrazolium violet (int) by h. pylori led us to develop a method for studying the effect of adding exogenous substrates on these reactions. the established procedure provided a profi ...19957574647
'cure' of helicobacter pylori. clinically indicated and economically wise! 19957575045
cost-effectiveness of helicobacter pylori eradication for the long-term management of duodenal ulcer in canada.a 1994 national institutes of health consensus panel recommended that eradication of helicobacter pylori should be first-line therapy for persons with duodenal ulcer.19957575049
surgery for peptic ulcer in the helicobacter pylori era. 19957575113
[helicobacter pylori and non-ulcerous dyspepsia++]. 19957578810
[chronic gastritis and helicobacter pylori in patients with non-ulcerous dyspepsia. role and significance of age].patients with recurrent upper abdominal complaints and without peptic ulcer or definite evidence of organic disease have been labelled as suffering from nonulcer dyspepsia and included in the study. a total of 125 patients were studied and upper gastrointestinal endoscopy performed. histology, urease rapid test and elisa serology were done in order to detect helicobacter pylori infection. age groups were done. the most frequent endoscopic and histological finding was chronic gastritis in all age ...19957578811
[antral biopsy in the prevention of gastric disease].approximately 1% of the gastric neoplasies are nowadays associated with the infection of the gastric mucus by helicobacter pylori. in view of the fact that its prevalency is very high and that it does not exist any objective and universal estimator in its diagnosis but the digestive endoscopy and biopsy, it is proposed, in candidate patients for a digestive endoscopy, although the explorer observes an endoscopic normality, to carry out, systematically, and antral biopsy for its subsequent diagno ...19957578812
selective adherence of a sucralfate-tetracycline complex to gastric ulcers: implications for the treatment of helicobacter pylori.the adherence of a sucralfate-tetracycline complex to gastric ulcers and to nearby non-ulcer sites was determined in the rabbit antrum. persistent gastric ulcers were produced by a previously described method. the presence of the complex was assessed 1 and 4 h after dosing. drug adherence was determined by quantitation of aluminum in stomach wall biopsies. significantly more aluminum adhered to ulcer sites than to nearby non-ulcer sites. adherence of the complex did not significantly decrease fr ...19957579029
the urea breath test: a non-invasive clinical tool for detecting helicobacter pylori infection.the urea breath test exploits the urease enzyme of helicobacter pylori. the hydrolysis of labelled urea releases labelled carbon dioxide that is excreted in the breath. distribution of urea throughout the stomach prevents sampling errors and allows for semiquantitative assessment of the extent of helicobacter pylori infection. the urea breath test is very specific and sensitive and can be proposed as the method of choice for detecting helicobacter pylori infection in ulcer patients before and af ...19957579592
helicobacter pylori in a group of endoscopically examined patients in the county of medimurje.the presence of helicobacter pylori was investigated in 50 patients, mean age 54 years and age range 28-56 years. gastroduodenoscopy and biopsy of the antral and/or pyloric part of gastric mucous membrane were performed in all study patients. bioptic tissue was examined by culture and histologic staining, and tested by a rapid urease test. according to overall results, the urease test was most sensitive, i.e. positive in 23 (45%) patients, whereas histological staining was positive in 14 (29) pa ...19957580042
peptic ulcer disease, helicobacter pylori, and the surgeon: changing of the guard.the ability to assign causative roles to helicobacter pylori and nonsteroidal anti-inflammatory drug use in peptic ulcer disease, and proof that eradication of h. pylori infection results in cure of peptic ulcer disease, are resulting in a reassessment of the indications for surgery and the type of surgery to be performed. with only a few exceptions, surgery is rapidly becoming an outdated approach to the management of peptic ulcer disease. we will soon see the day when surgeons with great techn ...19947583943
[an epidemiological survey on helicobacter pylori infection in children].in this study serum anti-urease antibodies of helicobacter pylori was examined in order to investigate the prevalence of h. pylori infection in 394 children between age 1 and 13. the results showed that the average infection rate was 15.7% with a tendency of increase infection rate with age, and by the age of 12 the h. pylori infection rate reached 30%, which was higher than those found in developed countries. we also noticed that there was a comparatively higher serapositivity among 1 and 7 yea ...19957585907
the role of serology in the diagnosis of helicobacter pylori infection in children.the aim of this study was to evaluate the diagnostic accuracy of serologic tests and to verify whether specific igg antibody can be used in the diagnosis of helicobacter pylori infection in children without endoscopy. serologic and endoscopic examinations were performed in 310 children (1 month-15 years) with gastrointestinal symptoms. serologic outcomes were compared with the results of rapid urease test, histologic examination, and culture. the prevalence of h. pylori infection was 21.0% and t ...19957586916
helicobacter pylori disease in childhood. 19957586917
[14c-urea breath test in the diagnosis of helicobacter pylori infection in the stomach].we developed a modified 14c-urea breath test (14c-ubt) to diagnose helicobacter pylori (hp) infection in 70 patients in which subjects were given 92.5 kbq (2.5 microci) 14c-urea with 25 mg nonradioactive urea, without nutrient-dense meal. using the mean value +3s as a cutoff value, the 20 min sample gave a sensitivity of 97.36%, a specificity of 90.00%, a positive predictive value of 97.36%, and a negative predictive value of 90.0%. our data showed: (1) a satisfying accuracy of the modified 14c- ...19957587602
detection and partial sequence analysis of helicobacter pylori dna in the bile samples.the existence of helicobacter pylori in the biliary tract was investigated. seven bile samples were included in this study. among them, six bile samples were collected by percutaneous transhepatic cholangiodrainage and the other by needle aspiration during cholecystectomy. using nested pcr with two sets of primers homologous to the urease a gene, helicobacter pylori dna was detected. three samples, one from a patient with advanced gastric cancer involving the pancreatic head and two from patient ...19957587792
influence of helicobacter pylori on tryptase and cathepsin d in peptic ulcer.we here ascertain whether tryptase (a serine endoprotease released by mast cells) and cathepsin d (cd, a lysosomal hydrolase that seems able to derange the extracellular matrix) play a part in peptic ulcer disease and whether they are linked to helicobacter pylori (hp) infection. we studied 13 controls, 25 patients with gastric ulcer, 47 with duodenal ulcer, and 11 with duodenitis. tryptase and cd were measured in mucosal biopsies (body and antrum of the stomach and duodenum) using irma methods. ...19957587835
[eradication of helicobacter pylori and treatment of the stomach ulcer]. 19957590043
helicobacter pylori and upper gastrointestinal disease: a survey of gastroenterologists in the united kingdom.the objective of this study was to conduct a survey of the opinions and practices of gastroenterologists in the united kingdom concerning the impact of helicobacter pylori infection on the management of upper gastrointestinal diseases. a postal questionnaire was sent to all medically qualified members of the british society of gastroenterology working in the uk. replies were received from 670 of 1037 eligible bsg members (65%). of these, 73% thought that h pylori was a cause of duodenal ulcer an ...19957590423
helicobacter pylori infection density and gastric inflammation in duodenal ulcer and non-ulcer subjects.the factors that determine which helicobacter pylori infected subjects develop duodenal ulcer (du) are unclear. this study tested the hypothesis that infection density and urease activity are higher in du than non-du subjects. fifty five du and 55 age and sex matched non-du subjects were studied. quantitative methods were used for measuring infection density (viable organism count) and urease activity (berthelot reaction). du subjects had a greater antral infection density (geometric mean of col ...19957590424
gastric metaplasia and helicobacter pylori infection. 19957590449
helicobacter pylori and gastric metaplasia of the duodenum. 19957590450
cloning and characterization of hemolytic genes from helicobacter pylori.strains of helicobacter pylori, the bacterium associated with gastritis, peptic ulcer disease, and gastric cancer in humans, express different degrees of hemolysis on agar containing erythrocytes (rbc). here we report the isolation and characterization of six recombinant clones from a genomic library of h. pylori atcc 49503 that confer on escherichia coli the ability to lyse sheep rbc. dna hybridizations indicated no sequence homology among these hemolytic clones. hybridization mapping of them t ...19957591069
helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies.we have attempted to express the helicobacter pylori vacuolating cytotoxin in escherichia coli. although the 95-kda vaca polypeptide was expressed abundantly, it completely lacked any biological activity. in addition, this material failed to induce neutralizing antibodies after immunization of rabbits. in contrast, highly purified high-molecular-mass cytotoxin from the supernatant of h. pylori cultures was active in a hela cell assay and effectively induced a neutralizing response in rabbits. ne ...19957591088
helicobacter pylori expresses a complex surface carbohydrate, lewis x.monoclonal antibodies (mabs) specific for lewis x (lex) reacted with whole cells of helicobacter pylori nctc11637, ua799, ua802, ua825, ua861, ua1182, and ua1206 in immunoelectron microscopy and enzyme-linked immunosorbent assay (elisa) experiments. these mabs have documented specificity to lex, whereas mabs for lea and leb were negative in both immunoelectron microscopy and elisa. h. pylori coccoid forms also reacted with the mabs, whereas the flagellum lacking the sheath showed no reactivity. ...19957591106
in vitro inhibition of helicobacter pylori nctc 11637 by organic acids and lactic acid bacteria.in this study the effects of both ph and organic acids on helicobacter pylori nctc 11637 were tested. lactobacillus acidophilus, lact. casei, lact. bulgaricus, pediococcus pentosaceus and bifidobacterium bifidus were assayed for their lactic acid production, ph and inhibition of h. pylori growth. a standard antimicrobial plate well diffusion assay was employed to examine inhibitory effects. lactic, acetic and hydrochloric acids demonstrated inhibition of h. pylori growth in a concentration-depen ...19957592140
the putative neuraminyllactose-binding hemagglutinin hpaa of helicobacter pylori ccug 17874 is a lipoprotein.the ability of certain strains of helicobacter pylori to cause sialic acid-sensitive agglutination of erythrocytes has been attributed to the hpaa protein (d.g. evans, t.k. karjalainen, d. j. evans, jr., d. y. graham, and c.h. lee, j. bacteriol. 175:674-683, 1993), the gene for which has been cloned and sequenced. on the basis of the hydropathy plot of hpaa and the presence of a potential lipoprotein signal sequence and modification site, and because of the similarities of these features with th ...19957592366
low ph activates the vacuolating toxin of helicobacter pylori, which becomes acid and pepsin resistant.the protein toxin vaca, produced by cytotoxic strains of helicobacter pylori, causes a vacuolar degeneration of cells, which eventually die. vaca is strongly activated by a short exposure to acidic solutions in the ph 1.5-5.5 range, followed by neutralization. activated vaca has different cd and fluorescence spectra and a limited proteolysis fragmentation pattern from vaca kept at neutral ph. moreover, activated vaca is resistant to ph 1.5 and to pepsin. the relevance of these findings to pathog ...19957592587
schönlein-henoch purpura associated with gastric helicobacter pylori infection.schönlein-henoch purpura is characterized by palpable purpura, colicky abdominal pain, gastrointestinal hemorrhage, arthralgias, and renal involvement. bacterial and viral infections, as well as drugs and diseases associated with immune complexes, are thought to be responsible. we describe the case of a 21-year-old woman with schönlein-henoch purpura and chronic active gastritis with erosions. helicobacter pylori was found in gastric mucosa using the newly introduced, nontoxic, noninvasive 13c-u ...19957593800
serodiagnosis of helicobacter pylori infection by enzyme-linked immunoelectrotransfer blot. gastrointestinal physiology working group of cayetano heredia university.immunoreactive bands in sera from 81 peruvian adults (48 females and 33 males) aged between 18 and 85 years were detected using enzyme-linked immunoelectrotransfer blot with a glycine-extracted helicobacter pylori antigen. sensitivity and specificity of bands were determined by comparison with results of h. pylori obtained by culture and silver stain of gastric biopsies. a crude antigen and a commercial enzyme-linked immunosorbent assay (pylori stat, whittaker) were also evaluated for their diag ...19957594313
suppression of acid secretion by lansoprazole and its effects on helicobacter pylori. ii. poster presentations from the 2nd international colloquium on proton pump inhibitors. houston, texas, september 29, 1994. 19957594319
gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazole and famotidine.we examined the effects of lansoprazole and famotidine on gastric basic fibroblast growth factor (bfgf) levels and ulcer healing in patients with gastric ulcer. sixteen patients with active gastric ulcer were divided into two groups and received treatment with lansoprazole 30 mg/day or famotidine 40 mg/day. they were examined endoscopically at 2, 4, and 8 weeks to measure gastric bfgf levels at the ulcer margin and to assess ulcer healing. helicobacter pylori infection was determined by a rapid ...19957594320
clinical efficacy of lansoprazole-amoxicillin treatment in eradicating helicobacter pylori: evaluation by the polymerase chain reaction method.the clinical efficacy of lansoprazole plus amoxicillin treatment in eradicating helicobacter pylori was examined in peptic ulcer patients. h. pylori eradication was assessed by the polymerase chain reaction (pcr) method in addition to conventional methods. fifteen h. pylori-positive patients with active peptic ulcers (10 duodenal ulcer patients and 5 gastric ulcer patients) were given lansoprazole 30 mg/day from day 1 to day 56 and amoxicillin 1,500 mg/day from day 15 to day 28. four weeks after ...19957594321
lansoprazole versus lansoprazole plus amoxicillin treatment for eradication of helicobacter pylori in patients with gastric ulcer.helicobacter pylori is a major cause of gastritis and an important factor in duodenal ulcer relapse. eradication of h. pylori has usually been achieved by triple therapy, a combination of bismuth salts and two antibiotics. the disadvantage of these regimens is the large number of tablets and the high incidence of side effects. a new h+,k(+)-atpase inhibitor, lansoprazole (lpz), has a strong acid inhibitory effect and an anti-h. pylori effect in vitro. these dual effects have an advantage for the ...19957594322
effects of lansoprazole with or without amoxicillin on ulcer healing: relation to eradication of helicobacter pylori.we studied the effects of lansoprazole with or without amoxicillin on the quality of ulcer healing in relation to eradication of helicobacter pylori. ulcer healing rates for lansoprazole 30 mg q.d. alone (group a) were 100% for duodenal ulcers (du; n = 20) and 92% for gastric ulcers (gu; n = 15). the healing rates for lansoprazole 30 mg plus amoxicillin 1-2 g q.d. (group b) were 100% for both du (n = 20) and gu (n = 12). endoscopic findings after treatment showed that the red scar/white scar rat ...19957594323
clinical efficacy of lansoprazole in eradication of helicobacter pylori.a randomized, single-blind study was designed to assess the effect of lansoprazole alone and lansoprazole plus amoxicillin on the healing and eradication rates in helicobacter pylori-associated peptic ulcer disease. seventy-nine patients with gastric ulcers and 54 patients with duodenal ulcers were randomly assigned to two treatment groups. group 1 received lansoprazole 30 mg daily for 8 weeks for gastric ulcers or 6 weeks for duodenal ulcers. group 2 received the group 1 regimen plus amoxicilli ...19957594324
13c-ubt using an infrared spectrometer for detection of helicobacter pylori and for monitoring the effects of lansoprazole.the stable isotope [13c]-labeled urea breath test (13c-ubt) is very useful for detecting helicobacter pylori. conventionally, a mass spectrometer is used to measure the presence of 13co2 in breath. however, this technique is complex and expensive. therefore, we carried out the 13c-ubt using an easy-to-operate infrared spectrometer, and we studied its usefulness. the 95 subjects included 35 patients with gastric ulcers, 32 with duodenal ulcers, 13 with gastroduodenal ulcers, some patients with no ...19957594325
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