Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| host antimicrobial peptides in bacterial homeostasis and pathogenesis of disease. | innate immune responses function as a first line of host defense against the development of bacterial infection, and in some cases to preserve the sterility of privileged sites in the human host. bacteria that enter these sites must counter host responses for colonization. from the host's perspective, the innate immune system works expeditiously to minimize the bacterial threat before colonization and subsequent dysbiosis. the multifactorial nature of disease further challenges predictions of ho ... | 2014 | 26029470 |
| microbial dynamics during conversion from supragingival to subgingival biofilms in an in vitro model. | the development of dental caries and periodontal diseases result from distinct shifts in the microbiota of the tooth-associated biofilm. this in vitro study aimed to investigate changes in biofilm composition and structure, during the shift from a 'supragingival' aerobic profile to a 'subgingival' anaerobic profile. biofilms consisting of actinomyces oris, candida albicans, fusobacterium nucleatum, streptococcus oralis, streptococcus mutans and veillonella dispar were aerobically grown in saliva ... | 2016 | 26033167 |
| extracellular glycoside hydrolase activities in the human oral cavity. | carbohydrate availability shifts when bacteria attach to a surface and form biofilm. when salivary planktonic bacteria form an oral biofilm, a variety of polysaccharides and glycoproteins are the primary carbon sources; however, simple sugar availabilities are limited due to low diffusion from saliva to biofilm. we hypothesized that bacterial glycoside hydrolase (gh) activities would be higher in a biofilm than in saliva in order to maintain metabolism in a low-sugar, high-glycoprotein environme ... | 2015 | 26048943 |
| evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water-soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. a randomized clinical trial. | to evaluate the clinical, microbiological and enzymatic activity of a hydrophobic chlorhexidine-based gingiva-adhering gel containing herbal ingredients, compared with a commercially available 1% chlorhexidine water-soluble gel, during non-surgical therapy of moderate chronic periodontitis. | 2017 | 26053503 |
| do oral bacteria alter the regenerative potential of stem cells? a concise review. | mesenchymal stem cells (mscs) are widely recognized as critical players in tissue regeneration. new insights into stem cell biology provide evidence that mscs may also contribute to host defence and inflammation. in case of tissue injury or inflammatory diseases, e.g. periodontitis, stem cells are mobilized towards the site of damage, thus coming in close proximity to bacteria and bacterial components. specifically, in the oral cavity, complex ecosystems of commensal bacteria live in a mutually ... | 2015 | 26058313 |
| genital cytomegalovirus replication predicts syphilis acquisition among hiv-1 infected men who have sex with men. | sexually transmitted infections (sti) are common among hiv-infected men who have sex with men (msm). while behavioral factors are important in sti acquisition, other biological factors such as immune modulation due to chronic viral infection may further predispose to sti acquisition. | 2015 | 26061824 |
| porphyromonas gingivalis periodontal infection and its putative links with alzheimer's disease. | periodontal disease (pd) and alzheimer's disease (ad) are inflammatory conditions affecting the global adult population. in the pathogenesis of pd, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and alveolar bone resorption around the teeth. in health, junctional epithelium seals the gingiva to the tooth enamel, thus preventing bacteria from entering the gingivae. chronic pd involves major pathogens (porphyromonas gingivalis, treponema dent ... | 2015 | 26063967 |
| mechanisms of bone resorption in periodontitis. | alveolar bone loss is a hallmark of periodontitis progression and its prevention is a key clinical challenge in periodontal disease treatment. bone destruction is mediated by the host immune and inflammatory response to the microbial challenge. however, the mechanisms by which the local immune response against periodontopathic bacteria disturbs the homeostatic balance of bone formation and resorption in favour of bone loss remain to be established. the osteoclast, the principal bone resorptive c ... | 2015 | 26065002 |
| erythritol-enriched air-polishing powder for the surgical treatment of peri-implantitis. | peri-implantitis represents a major complication that can compromise the success and survival of implant-supported rehabilitations. both surgical and nonsurgical treatment protocols were proposed to improve clinical parameters and to treat implants affected by peri-implantitis. a systematic review of the literature was performed on electronic databases. the use of air-polishing powder in surgical treatment of peri-implantitis was investigated. a total of five articles, of different study designs ... | 2015 | 26065025 |
| draft genome sequence of tannerella forsythia type strain atcc 43037. | tannerella forsythia is an oral pathogen implicated in the development of periodontitis. here, we report the draft genome sequence of the tannerella forsythia strain atcc 43037. the previously available genome of this designation (ncbi reference sequence nc_016610.1) was discovered to be derived from a different strain, fdc 92a2 (= atcc baa-2717). | 2015 | 26067981 |
| complement system part ii: role in immunity. | the complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism. nowadays, this vision has changed and it is well accepted that complement is a complex innate immune surveillance system, playing a key role in host homeostasis, inflammation, and in the defense against pathogens. this review discusses recent advances in the understanding of the role of complement in physiology and pathology. it starts with a description of com ... | 2015 | 26074922 |
| subgingival microbiome in patients with healthy and ailing dental implants. | dental implants are commonly used to replace missing teeth. however, the dysbiotic polymicrobial communities of peri-implant sites are responsible for peri-implant diseases, such as peri-implant mucositis and peri-implantitis. in this study, we analyzed the microbial characteristics of oral plaque from peri-implant pockets or sulci of healthy implants (n = 10), peri-implant mucositis (n = 8) and peri-implantitis (n = 6) sites using pyrosequencing of the 16s rrna gene. an increase in microbial di ... | 2015 | 26077225 |
| lessons from microglia aging for the link between inflammatory bone disorders and alzheimer's disease. | bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. on the other hand, neuroinflammation is strongly implicated in alzheimer's disease (ad), which can be enhanced by systemic inflammation, such as that due to cardiovascular disease and diabetes. there is growing clinical evidence supporting the concept that rheumatoid arthritis and peri ... | 2015 | 26078980 |
| fusobacterium nucleatum alters atherosclerosis risk factors and enhances inflammatory markers with an atheroprotective immune response in apoe(null) mice. | the american heart association supports an association between periodontal disease (pd) and atherosclerotic vascular disease (asvd) but does not as of yet support a causal relationship. recently, we have shown that major periodontal pathogens porphyromonas gingivalis and treponema denticola are causally associated with acceleration of aortic atherosclerosis in apoenull hyperlipidemic mice. the aim of this study was to determine if oral infection with another significant periodontal pathogen fuso ... | 2015 | 26079509 |
| periodontal bacteria and prediabetes prevalence in origins: the oral infections, glucose intolerance, and insulin resistance study. | periodontitis and type 2 diabetes mellitus are known to be associated. the relationship between periodontal microbiota and early diabetes risk has not been studied. we investigated the association between periodontal bacteria and prediabetes prevalence among diabetes-free adults. origins (the oral infections, glucose intolerance and insulin resistance study) cross sectionally enrolled 300 diabetes-free adults aged 20 to 55 y (mean ± sd, 34 ± 10 y; 77% female). prediabetes was defined as follows: ... | 2015 | 26082387 |
| a randomized trial of ethyl lauroyl arginate-containing mouthrinse in the control of gingivitis. | this 4-week, single-centre, randomized, examiner-blind, controlled study investigated the efficacy and safety of 0.15% ethyl lauroyl arginate (lae)-containing mouthrinse in adults with mild-to-moderate gingivitis. | 2015 | 26087864 |
| prevalence of eight putative periodontal pathogens in atherosclerotic plaque of coronary artery disease patients and comparing them with noncardiac subjects: a case-control study. | the study was aimed to assess the prevalence of periodontal pathogens namely tannerella forsythia (t.f), campylobacter rectus (c.r), eikenella corrodens (e.c), porphyromonas gingivalis (p.g), treponema denticola (t.d), prevotella nigrescens (p.n) ,aggregatibacter actinomycetemcomitans (a.a), p.g (fi ma gene) and prevotella intermedia (p.i), in the subgingival and the atheromatous plaque of patients with coronary artery disease (cad), and comparing them with the noncardiac subjects thereby indica ... | 2017 | 26096116 |
| aminoimidazole carboxamide ribotide exerts opposing effects on thiamine synthesis in salmonella enterica. | in salmonella enterica, the thiamine biosynthetic intermediate 5-aminoimidazole ribotide (air) can be synthesized de novo independently of the early purine biosynthetic reactions. this secondary route to air synthesis is dependent on (i) 5-amino-4-imidazolecarboxamide ribotide (aicar) accumulation, (ii) a functional phosphoribosylaminoimidazole-succinocarboxamide (saicar) synthetase (purc; ec 6.3.2.6), and (iii) methionine and lysine in the growth medium. studies presented here show that aicar i ... | 2015 | 26100042 |
| diversity-generating retroelements in phage and bacterial genomes. | diversity-generating retroelements (dgrs) are dna diversification machines found in diverse bacterial and bacteriophage genomes that accelerate the evolution of ligand-receptor interactions. diversification results from a unidirectional transfer of sequence information from an invariant template repeat (tr) to a variable repeat (vr) located in a protein-encoding gene. information transfer is coupled to site-specific mutagenesis in a process called mutagenic homing, which occurs through an rna in ... | 2014 | 26104433 |
| comparative study of abdominal and thoracic aortic aneurysms: their pathogenesis and a gingival fibroblasts-based ex vivo treatment. | aortic aneurysms (aas) consist of slow proteolysis and loss of both collagen and elastin matrix in the aorta wall, leading to wall dilation, weakening and rupture in well-advanced lesions. this can occur in both abdominal aorta (abdominal aortic aneurysm: aaa) and thoracic aorta (thoracic aortic aneurysm: taa). to date, no non-surgical therapy has been proposed to slow or stop aa progression. previously published preclinical studies from our team using an aneurysm rabbit model showed a promising ... | 2015 | 26110102 |
| polybacterial periodontal pathogens alter vascular and gut bh4/nnos/nrf2-phase ii enzyme expression. | periodontal disease is a highly prevalent chronic inflammatory disease and is associated with complex microbial infection in the subgingival cavity. recently, american heart association supported a century old association between periodontal disease and atherosclerotic vascular disease. we have recently shown that polybacterial periodontal infection led to aortic atherosclerosis and modulation of lipid profiles; however the underlying mechanism(s) has not been yet demonstrated. altered nitric ox ... | 2015 | 26111153 |
| the biofilm community-rebels with a cause. | oral biofilms are one of the most complex and diverse ecosystem developed by successive colonization of more than 600 bacterial taxa. development starts with the attachment of early colonizers such as actinomyces species and oral streptococci on the acquired pellicle and tooth enamel. these bacteria not only adhere to tooth surface but also interact with each other and lay foundation for attachment of bridging colonizer such as fusobacterium nucleatum followed by late colonizers including the re ... | 2015 | 26120510 |
| a biofilm pocket model to evaluate different non-surgical periodontal treatment modalities in terms of biofilm removal and reformation, surface alterations and attachment of periodontal ligament fibroblasts. | there is a lack of suitable in vitro models to evaluate various treatment modalities intending to remove subgingival bacterial biofilm. consequently, the aims of this in vitro-study were: a) to establish a pocket model enabling mechanical removal of biofilm and b) to evaluate repeated non-surgical periodontal treatment with respect to biofilm removal and reformation, surface alterations, tooth hard-substance-loss, and attachment of periodontal ligament (pdl) fibroblasts. | 2015 | 26121365 |
| inter-individual differences in the oral bacteriome are greater than intra-day fluctuations in individuals. | given the advent of massively parallel dna sequencing, human microbiome is analyzed comprehensively by metagenomic approaches. however, the inter- and intra-individual variability and stability of the human microbiome remain poorly characterized, particularly at the intra-day level. this issue is of crucial importance for studies examining the effects of microbiome on human health. here, we focused on bacteriome of oral plaques, for which repeated, time-controlled sampling is feasible. eighty-on ... | 2015 | 26121551 |
| periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased dominican adults. | the objective of this study was to compare the periodontopathogen prevalence and tetracycline resistance genes in dominican patients with different periodontal conditions. | 2015 | 26121972 |
| periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased dominican adults. | the objective of this study was to compare the periodontopathogen prevalence and tetracycline resistance genes in dominican patients with different periodontal conditions. | 2015 | 26121972 |
| crisprs provide broad and robust protection to oral microbial flora of gingival health against bacteriophage challenge. | 2015 | 26123805 | |
| the influence of smoking on the peri-implant microbiome. | smokers are at high risk for 2 bacterially driven oral diseases: peri-implant mucositis and peri-implantitis. therefore, the purpose of this investigation was to use a deep-sequencing approach to identify the effect of smoking on the peri-implant microbiome in states of health and disease. peri-implant biofilm samples were collected from 80 partially edentulous subjects with peri-implant health, peri-implant mucositis, and peri-implantitis. bacterial dna was isolated and 16s ribsomal rna gene li ... | 2015 | 26124222 |
| estimation of bacterial hydrogen sulfide production in vitro. | oral bacterial hydrogen sulfide (h2s) production was estimated comparing two different colorimetric methods in microtiter plate format. high h2s production was seen for fusobacterium spp., treponema denticola, and prevotella tannerae, associated with periodontal disease. the production differed between the methods indicating that h2s production may follow different pathways. | 2015 | 26130377 |
| the role of the local microbial ecosystem in respiratory health and disease. | respiratory tract infections are a major global health concern, accounting for high morbidity and mortality, especially in young children and elderly individuals. traditionally, highly common bacterial respiratory tract infections, including otitis media and pneumonia, were thought to be caused by a limited number of pathogens including streptococcus pneumoniae and haemophilus influenzae. however, these pathogens are also frequently observed commensal residents of the upper respiratory tract (ur ... | 2015 | 26150660 |
| antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells. | nisin is a lantibiotic widely used for the preservation of food and beverages. recently, investigators have reported that nisin may have clinical applications for treating bacterial infections. the aim of this study was to investigate the effects of ultra pure food grade nisin zp (>95% purity) on taxonomically diverse bacteria common to the human oral cavity and saliva derived multi-species oral biofilms, and to discern the toxicity of nisin against human cells relevant to the oral cavity. | 2015 | 26150809 |
| elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis. | elastase and metalloproteinase-9 (mmp-9) are two of numerous proteolytic enzymes released by neutrophilic granulocytes in the course of periodontitis. the aim of the study was to determine the concentrations of elastase and mmp-9 in saliva in patients with chronic periodontitis compared to healthy individuals. the enzyme-linked immunosorbent assay method was employed to determine the concentrations of elastase and mmp-9 in saliva in patients with chronic periodontitis and with pocket depth (pd) ... | 2014 | 26155148 |
| a modified shuttle plasmid facilitates expression of a flavin mononucleotide-based fluorescent protein in treponema denticola atcc 35405. | oral pathogens, including treponema denticola, initiate the dysregulation of tissue homeostasis that characterizes periodontitis. however, progress of research on the roles of t. denticola in microbe-host interactions and signaling, microbial communities, microbial physiology, and molecular evolution has been hampered by limitations in genetic methodologies. this is typified by an extremely low transformation efficiency and inability to transform the most widely studied t. denticola strain with ... | 2015 | 26162875 |
| animal models of polymicrobial pneumonia. | pneumonia is one of the leading causes of severe and occasionally life-threatening infections. the physiopathology of pneumonia has been extensively studied, providing information for the development of new treatments for this condition. in addition to in vitro research, animal models have been largely used in the field of pneumonia. several models have been described and have provided a better understanding of pneumonia under different settings and with various pathogens. however, the concept o ... | 2015 | 26170617 |
| effects of hangeshashinto on growth of oral microorganisms. | oral mucositis (om) in cancer patients induced by chemotherapy or radiotherapy has a significant impact on quality of life, and causes considerable morbidity. oral microorganisms are likely to intensify the inflammatory process and aggravate the formation of ulcers. hangeshashinto (hst), a japanese kampo medicine, has been reported to be effective when used as a gargle for the treatment of om. to clarify the effects of hst on oral microorganisms, we assessed its antimicrobial activity against 27 ... | 2015 | 26170876 |
| impact of heavy smoking on the clinical, microbiological and immunological parameters of patients with dental implants: a prospective cross-sectional study. | the aim of the present study was to investigate how heavy smoking influences the clinical, microbiological, and host-response characteristics in peri-implant sulcus fluid of patients with healthy dental implants. | 2016 | 26171870 |
| butanol production in s. cerevisiae via a synthetic abe pathway is enhanced by specific metabolic engineering and butanol resistance. | the fermentation of sugars to alcohols by microbial systems underpins many biofuel initiatives. short chain alcohols, like n-butanol, isobutanol and isopropanol, offer significant advantages over ethanol in terms of fuel attributes. however, production of ethanol from resistant saccharomyces cerevisiae strains is significantly less complicated than for these alternative alcohols. | 2015 | 26175798 |
| tonsillar syphilis: an unusual site of infection detected by treponema pallidum pcr. | with the reemergence of syphilis, it is important that both clinical and public health practitioners recognize the various clinical manifestations of this disease (formerly known as "the great imitator") and become familiar with the newer diagnostic tests. here we report the first case of tonsillar syphilis diagnosed by pcr. | 2015 | 26179306 |
| small rna transcriptome of the oral microbiome during periodontitis progression. | the oral microbiome is one of the most complex microbial communities in the human body, and due to circumstances not completely understood, the healthy microbial community becomes dysbiotic, giving rise to periodontitis, a polymicrobial inflammatory disease. we previously reported the results of community-wide gene expression changes in the oral microbiome during periodontitis progression and identified signatures associated with increasing severity of the disease. small noncoding rnas (srnas) a ... | 2015 | 26187962 |
| exploring salivary microbiota in aids patients with different periodontal statuses using 454 gs-flx titanium pyrosequencing. | patients with acquired immunodeficiency syndrome (aids) are at high risk of opportunistic infections. oral manifestations have been associated with the level of immunosuppression, these include periodontal diseases, and understanding the microbial populations in the oral cavity is crucial for clinical management. the aim of this study was to examine the salivary bacterial diversity in patients newly admitted to the aids ward of the public health clinical center (china). saliva samples were colle ... | 2015 | 26191508 |
| detection of subgingival periodontal pathogens--comparison of two sampling strategies. | the aim of the study is to compare detection frequency of periodontal pathogens in patients with aggressive/severe chronic periodontitis using pooled plaque samples from the deepest pockets per quadrant/per sextant. | 2016 | 26193958 |
| association of porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients. | the aim of the present study was to evaluate the association between the occurrence of periodontopathogens with cortisol levels in chronic periodontitis patients. | 2016 | 26194628 |
| association between periodontitis and alzheimer's disease. | alzheimer's disease (ad) is a neurodegenerative disease which significantly increases with age. its onset can be either early or late. ad is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (cns). whereas, periodontitis is a common oral infection associated with the gram negative anaerobic bacteria. periodontitis can be marked as a "low-grade syste ... | 2015 | 26199919 |
| papillon-lefèvre syndrome: clinical presentation and management options. | papillon-lefèvre syndrome (pls) is a rare autosomal recessive disorder, characterized by diffuse palmoplantar keratoderma and precocious aggressive periodontitis, leading to premature loss of deciduous and permanent dentition at a very young age. various etiopathogenic factors are associated with the syndrome, like immunologic alterations, genetic mutations, and the role of bacteria. dentists play a significant role in the diagnosis and management of pls as there are characteristic manifestation ... | 2015 | 26203280 |
| a metalloproteinase mirolysin of tannerella forsythia inhibits all pathways of the complement system. | recent reports focusing on virulence factors of periodontal pathogens implicated proteinases as major determinants of remarkable pathogenicity of these species, with special emphasis on their capacity to modulate complement activity. in particular, bacteria-mediated cleavage of c5 and subsequent release of c5a seems to be an important phenomenon in the manipulation of the local inflammatory response in periodontitis. in this study, we present mirolysin, a novel metalloproteinase secreted by tann ... | 2015 | 26209620 |
| transcriptome analysis of bacteriophage communities in periodontal health and disease. | the role of viruses as members of the human microbiome has gained broader attention with the discovery that human body surfaces are inhabited by sizeable viral communities. the majority of the viruses identified in these communities have been bacteriophages that predate upon cellular microbiota rather than the human host. phages have the capacity to lyse their hosts or provide them with selective advantages through lysogenic conversion, which could help determine the structure of co-existing bac ... | 2015 | 26215258 |
| macrolide resistance in the syphilis spirochete, treponema pallidum ssp. pallidum: can we also expect macrolide-resistant yaws strains? | treponema pallidum ssp. pallidum (tpa) causes over 10 million new cases of syphilis worldwide whereas t. pallidum ssp. pertenue (tpe), the causative agent of yaws, affects about 2.5 million people. although penicillin remains the drug of choice in the treatment of syphilis, in penicillin-allergic patients, macrolides have been used in this indication since the 1950s. failures of macrolides in syphilis treatment have been well documented in the literature and since 2000, there has been a dramatic ... | 2015 | 26217043 |
| host response mechanisms in periodontal diseases. | periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, tannerella forsythia and treponema denticola that trigger innate, inflammatory, and adaptive immune responses. these processes result in the destruction of the tissues surrounding and supporting the teeth, and eventually in tissue, bone and final ... | 2015 | 26221929 |
| the association of active and secondhand smoking with oral health in adults: japan public health center-based study. | smoking is one of the major risk factors for oral diseases, and many studies have found that active smoking is closely associated with the prevalence or severity of periodontal disease and fewer remaining teeth. in contrast to the established association between active smoking and oral health, there have been very few studies investigating the effects of secondhand smoking on oral health, and whether secondhand smoking deteriorates oral health has not been fully clarified. the purpose of the pre ... | 2015 | 26225132 |
| periodontal diseases: bug induced, host promoted. | 2015 | 26226364 | |
| evaluation of anti-inflammatory effects of curcumin gel as an adjunct to scaling and root planing: a clinical study. | complete removal of irritants is not possible with mechanical therapy alone. adjunctive use of systemic administration of antibiotics results in the distribution of drug throughout the body, which can give rise to toxicity. curcumin (diferuloylmethane), a constituent of curcuma longa plant, which possess antioxidant, anti-inflammatory, anti-carcinogenic, anti-microbial, anti-hyper algesic and hypocholesterolemic properties. the aim of the present study is to compare the effects of the curcumin g ... | 2015 | 26229378 |
| periodontal disease: a possible risk-factor for adverse pregnancy outcome. | bacterial invasion in subgingival sites especially of gram-negative organisms are initiators for periodontal diseases. the periodontal pathogens with persistent inflammation lead to destruction of periodontium. in recent years, periodontal diseases have been associated with a number of systemic diseases such as rheumatoid arthritis, cardiovascular-disease, diabetes mellitus, chronic respiratory diseases and adverse pregnancy outcomes including pre-term low-birth weight (plbw) and pre-eclampsia. ... | 2015 | 26229389 |
| periodontal health awareness among gynecologists in riyadh, saudi arabia. | to determine the knowledge of periodontal disease and pregnancy outcomes among the gynecologists practicing in riyadh, saudi arabia. | 2015 | 26236681 |
| the inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. | inflammasomes are an oligomeric assembly of multiprotein complexes that activate the caspase-1-dependent maturation and the subsequent secretion of inflammatory interleukin-1beta and interleukin-18 cytokines in response to a 'danger signal' in vertebrates. the assessment of their significance continues to grow rapidly as the complex biology of various chronic inflammatory conditions is better dissected. increasing evidence strongly links inflammasomes and host-derived small 'danger molecule atp' ... | 2015 | 26252403 |
| clinical and microbiologic evaluation of scaling and root planing per quadrant and one-stage full-mouth disinfection associated with azithromycin or chlorhexidine: a clinical randomized controlled trial. | conflicting data about the protocol of choice for non-surgical periodontal therapy with adjuvant use are still reported. this study aims to evaluate, through clinical and microbiologic parameters, the systemic use of azithromycin (az) and chlorhexidine (chx) as adjuvants to non-surgical periodontal treatment performed by one-stage full-mouth disinfection (fmd) within 24 hours or conventional quadrant scaling (qs) in four weekly sections. | 2015 | 26252751 |
| alcohol selectivity in a synthetic thermophilic n-butanol pathway is driven by biocatalytic and thermostability characteristics of constituent enzymes. | n-butanol is generated as a natural product of metabolism by several microorganisms, but almost all grow at mesophilic temperatures. a synthetic pathway for n-butanol production from acetyl coenzyme a (acetyl-coa) that functioned at 70°c was assembled in vitro from enzymes recruited from thermophilic bacteria to inform efforts for engineering butanol production into thermophilic hosts. recombinant versions of eight thermophilic enzymes (β-ketothiolase [thl], 3-hydroxybutyryl-coa dehydrogenase [h ... | 2015 | 26253677 |
| evaluation of ciprofloxacin and metronidazole encapsulated biomimetic nanomatrix gel on enterococcus faecalis and treponema denticola. | a triple antibiotic mixture (ciprofloxacin; cf, metronidazole; mn, and minocycline; mc) has been used for dental root canal medicaments in pulp regeneration therapy. however, tooth discolorations, cervical root fractures, and inadequate pulp-dentin formation have been reported due to the triple antibiotic regimen. therefore, an antibiotic encapsulated biomimetic nanomatrix gel was developed to minimize the clinical limitations and maximize a natural healing process in root canal infections. in t ... | 2015 | 26257918 |
| oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients. | the objective of this study was to identify the dna of oral bacteria in placental samples from women with and without periodontitis who had or had not had preterm births and/or low birthweight (pb/lbw) neonates. | 2015 | 26259070 |
| green tea modulates cytokine expression in the periodontium and attenuates alveolar bone resorption in type 1 diabetic rats. | diabetes mellitus comprises a heterogeneous group of disorders with the main feature of hyperglycemia. chronic hyperglycemia increases the severity of periodontal disease via an exacerbated inflammatory response, activated by advanced glycation end products and their receptor, rage. therefore, anti-inflammatory agents represent potential inhibitors of this pathological interaction. in particular, green tea has been shown to possess anti-inflammatory properties mediated by its polyphenol content. | 2015 | 26270535 |
| long-term evaluation of the antimicrobial susceptibility and microbial profile of subgingival biofilms in individuals with aggressive periodontitis. | this study evaluates the antimicrobial susceptibility and composition of subgingival biofilms in generalized aggressive periodontitis (gap) patients treated using mechanical/antimicrobial therapies, including chlorhexidine (chx), amoxicillin (amx) and metronidazole (met). gap patients allocated to the placebo (c, n = 15) or test group (t, n = 16) received full-mouth disinfection with chx, scaling and root planning, and systemic amx (500 mg)/met (250 mg) or placebos. subgingival plaque samples we ... | 2015 | 26273264 |
| the gastrointestinal tract as a potential infection reservoir of digital dermatitis-associated treponemes in beef cattle and sheep. | digital dermatitis (dd) is an important cause of lameness in dairy cattle worldwide. it has now been reported in beef cattle and also sheep (contagious ovine digital dermatitis [codd]). three treponema phylogroups are consistently isolated from lesions, treponema medium-like, treponema phagedenis-like, and treponema pedis. the gastrointestinal (gi) tract and feces are suggested sites of treponemal infection in dairy cattle; however, isolation of dd-associated treponemes from these areas has prev ... | 2015 | 26276110 |
| periodontal microbiota and phospholipases: the oral infections and vascular disease epidemiology study (invest). | periodontal infections have been linked to cardiovascular disease, including atherosclerosis, and systemic inflammation has been proposed as a possible mediator. secretory phospholipase a2 (s-pla2) and lipoprotein-associated pla2 (lp-pla2) are inflammatory enzymes associated with atherosclerosis. no data are available on the association between oral microbiota and pla2s. we studied whether a relationship exists between periodontal microbiota and the activities of these enzymes. | 2015 | 26282947 |
| conservation of the host-interacting proteins tp0750 and pallilysin among treponemes and restriction of proteolytic capacity to treponema pallidum. | the spirochete treponema pallidum subsp. pallidum is the causative agent of syphilis, a chronic, sexually transmitted infection characterized by multiple symptomatic and asymptomatic stages. although several other species in the genus are able to cause or contribute to disease, t. pallidum differs in that it is able to rapidly disseminate via the bloodstream to tissue sites distant from the site of initial infection. it is also the only treponema species able to cross both the blood-brain and pl ... | 2015 | 26283341 |
| microbiologic findings in relation to risk assessment for periodontal disease: a cross-sectional study. | in this study, an association between a computerized risk calculator and microbiologic testing is examined in patients with periodontitis. | 2016 | 26291297 |
| the expression of gingival epithelial junctions in response to subgingival biofilms. | periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. it is caused by the formation of subgingival biofilms on the surface of the tooth. characteristic bacteria associated with subgingival biofilms are the gram-negative anaerobes porphyromonas gingivalis, tannerella forsythia and treponema denticola, collectively known as the "red complex" species. inter-epithelial junctions ensure the barrier integrity of the gingival epithelium. this may however be dis ... | 2015 | 26305580 |
| complement involvement in periodontitis: molecular mechanisms and rational therapeutic approaches. | the complement system is a network of interacting fluid-phase and cell surface-associated molecules that trigger, amplify, and regulate immune and inflammatory signaling pathways. dysregulation of this finely balanced network can destabilize host-microbe homeostasis and cause inflammatory tissue damage. evidence from clinical and animal model-based studies suggests that complement is implicated in the pathogenesis of periodontitis, a polymicrobial community-induced chronic inflammatory disease t ... | 2015 | 26306443 |
| the association between subgingival periodontal pathogens and systemic inflammation. | to investigate associations between periodontal disease pathogens and levels of systemic inflammation measured by c-reactive protein (crp). | 2015 | 26309048 |
| porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, and treponema denticola / prevotella intermedia co-infection are associated with severe periodontitis in a thai population. | periodontitis is a polymicrobial infection of tooth-supporting tissues. this cross-sectional study aimed to examine the associations between five target species and severe periodontitis in a thai population. using the cdc/aap case definition, individuals diagnosed with no/mild and severe periodontitis were included. quantitative analyses of aggregatibacter actinomycetemcomitans (aa), porphyromonas gingivalis (pg), tannerella forsythia (tf), treponema denticola (td), and prevotella intermedia (pi ... | 2015 | 26313005 |
| oxidative stress and igg antibody modify periodontitis-crp association. | in a previous report, we demonstrated the inverse association of high serum 8-isoprostane levels, a marker for oxidative stress, with decreased serum igg antibodies to oral bacteria. the association between increased serum igg with increased plaque and periodontitis (increased probing depths) was attenuated by high systemic oxidative stress. other investigations have reported a role for systemic oxidative stress as a stimulus of hepatic c-reactive protein (crp) response. these observations led u ... | 2015 | 26318589 |
| association of levels of antibodies against citrullinated cyclic peptides and citrullinated α-enolase in chronic and aggressive periodontitis as a risk factor of rheumatoid arthritis: a case control study. | periodontal disease could be a risk factor for rheumatoid arthritis (ra). it is assumed that the bacterial strain porphyromonas gingivalis mediates citrullination of host peptides and thereby the generation of ra-associated autoantibodies in genetically predisposed individuals. for that reason non-ra individuals who suffered from generalized aggressive (gagp, n = 51) and generalized chronic periodontitis (gchp, n = 50) were investigated regarding the occurrence of antibodies against citrullinate ... | 2015 | 26319714 |
| correlation of salivary immunoglobulin a against lipopolysaccharide of porphyromonas gingivalis with clinical periodontal parameters. | a major challenge in clinical periodontics is to find a reliable molecular marker of periodontal tissue destruction. | 2015 | 26321825 |
| periodontal disease and tooth loss as risks for cancer: a systematic review of the literature. | periodontal disease is a chronic destructive disease which occurs in adults, young people, and children. periodontal disease and periodontal pathogens have been associated with several systemic diseases and more recently, several studies have suggested the relationship between periodontal disease and cancer. studies with adjustment for the effect of smoking exposure, have found significant positive associations with different cancer sites. this review has outlined recent epidemiologic researches ... | 2011 | 26322197 |
| differential distribution of type ii crispr-cas systems in agricultural and nonagricultural campylobacter coli and campylobacter jejuni isolates correlates with lack of shared environments. | crispr (clustered regularly interspaced palindromic repeats)-cas (crispr-associated) systems are sequence-specific adaptive defenses against phages and plasmids which are widespread in prokaryotes. here we have studied whether phylogenetic relatedness or sharing of environmental niches affects the distribution and dissemination of type ii crispr-cas systems, first in 132 bacterial genomes from 15 phylogenetic classes, ranging from proteobacteria to actinobacteria. there was clustering of distinc ... | 2015 | 26338188 |
| the two-way association of periodontal infection with systemic disorders: an overview. | oral cavity that harbors diverse bacterial populations could also act as a site of origin for spread of pathogenic microorganisms to different body sites, particularly in immunocompromised hosts, patients, the elderly, or the underprivileged. a number of recent publications have advocated that patients with periodontal diseases are more susceptible to metabolic endotoxemia, inflammation, obesity, type 2 diabetes, and other related systemic complications, concluding that periodontal diseases coul ... | 2015 | 26339142 |
| presence of bacteria in failed anterior cruciate ligament reconstructions. | novel microbial detection technologies have revealed that chronic bacterial biofilms, which are recalcitrant to antibiotic treatment, are common in failed orthopedic procedures. | 2015 | 26339561 |
| microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. | the purpose of this study was to compare the microbial and clinical effects of mechanical debridement (md) alone or in combination with the application of enamel matrix derivative (emd) and sustained-release micro-spherical minocycline (msm) for treatment of peri-implant mucosal infl ammation (pimi). | 2015 | 26339576 |
| analysis of the microbiota of black stain in the primary dentition. | black tooth stain is a characteristic extrinsic discoloration commonly seen on the cervical enamel following the contour of the gingiva. to investigate the relationship between black tooth stain and the oral microbiota, we used 16s rrna gene sequencing to compare the microbial composition of dental plaque and saliva among caries-free children with and without black stain. dental plaque and saliva, as well as black stain, were sampled from 10 children with and 15 children without black stain. dat ... | 2015 | 26340752 |
| biogenesis and function of porphyromonas gingivalis outer membrane vesicles. | porphyromonas gingivalis is one of the keystone pathogens associated with chronic periodontitis. all p. gingivalis strains examined thus far produce outer membrane vesicles. recent studies have found that vesicles possess some well-known virulence factors of p. gingivalis such as adhesins, toxins and proteolytic enzymes. carrying most of the characteristic features of their parent p. gingivalis cells, vesicles communicate with host cells and other members of microbial biofilms, resulting in the ... | 2015 | 26343879 |
| modular design of metabolic network for robust production of n-butanol from galactose-glucose mixtures. | refactoring microorganisms for efficient production of advanced biofuel such as n-butanol from a mixture of sugars in the cheap feedstock is a prerequisite to achieve economic feasibility in biorefinery. however, production of biofuel from inedible and cheap feedstock is highly challenging due to the slower utilization of biomass-driven sugars, arising from complex assimilation pathway, difficulties in amplification of biosynthetic pathways for heterologous metabolite, and redox imbalance caused ... | 2015 | 26347006 |
| role of host cell-derived amino acids in nutrition of intracellular salmonella enterica. | the facultative intracellular pathogen salmonella enterica resides in a specific membrane-bound compartment termed the salmonella-containing vacuole (scv). despite being segregated from access to metabolites in the host cell cytosol, salmonella is able to efficiently proliferate within the scv. we set out to unravel the nutritional supply of salmonella in the scv with focus on amino acids. we studied the availability of amino acids by the generation of auxotrophic strains for alanine, asparagine ... | 2015 | 26351287 |
| qat chewing and periodontal pathogens in health and disease: further evidence for a prebiotic-like effect. | qat chewing has been reported to induce subgingival microbial shifts suggestive of prebiotic-like properties. the objective here was to assess the effect of qat chewing on a panel of classical and new putative periopathogens in health and periodontitis. | 2015 | 26351631 |
| subgingivally applied minocycline microgranules in subjects with chronic periodontitis: a randomized clinical and microbiological trial. | the aim of this study was to evaluate clinical and microbiological effects of subgingival minocycline microgranules when used as an adjunct to scaling and root planing in subjects with chronic periodontitis. twenty-six non-smoker volunteers participated in the study. four opposite sites, clinically standardized, with bleeding on probing (bop) and pocket depth (pd) ≥ 6 mm were selected. baseline bop, pd and clinical attachment level (cal) were measured and microbiological samples were collected f ... | 2015 | 26355881 |
| periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvβ6 integrin-deficient mice. | the american heart association supports an association between periodontal diseases and atherosclerosis but not a causal association. this study explores the use of the integrin β6(-/-) mouse model to study the causality. we investigated the ability of a polymicrobial consortium of porphyromonas gingivalis, treponema denticola, tannerella forsythia, and fusobacterium nucleatum to colonize the periodontium and induce local and systemic inflammatory responses. polymicrobially infected itgβ6(-/-) m ... | 2015 | 26371120 |
| a randomized clinical trial of an adjunct diode laser application for the nonsurgical treatment of peri-implantitis. | in this radiographic and microbiologic split-mouth clinical trial, efficacy of a diode laser as an adjunct to conventional scaling in the nonsurgical treatment of peri-implantitis was investigated. | 2015 | 26382562 |
| can oral infection be a risk factor for alzheimer's disease? | alzheimer's disease (ad) is a scourge of longevity that will drain enormous resources from public health budgets in the future. currently, there is no diagnostic biomarker and/or treatment for this most common form of dementia in humans. ad can be of early familial-onset or sporadic with a late-onset. apart from the two main hallmarks, amyloid-beta and neurofibrillary tangles, inflammation is a characteristic feature of ad neuropathology. inflammation may be caused by a local central nervous sys ... | 2015 | 26385886 |
| calcium regulates the activity and structural stability of tpr, a bacterial calpain-like peptidase. | porphyromonas gingivalis is a peptide-fermenting asaccharolytic periodontal pathogen. its genome contains several genes encoding cysteine peptidases other than gingipains. one of these genes (pg1055) encodes a protein called tpr (thiol protease) that has sequence similarity to cysteine peptidases of the papain and calpain families. in this study we biochemically characterize tpr. we found that the 55-kda tpr inactive zymogen proteolytically processes itself into active forms of 48, 37, and 33 kd ... | 2015 | 26385924 |
| the novel association between red complex of oral microbe and body mass index in healthy japanese: a population based cross-sectional study. | microbiota has been thought to be one of important environmental factors for obesity or type 2 diabetes mellitus. among oral microbe, porphyromonas gingivalis, treponema denticola and tannellera forsythia are known as risk factors, so called red complex, for periodontitis. red complex could also be a risk factor for obesity. however, recent study indicated that obesity was not improved by periodontal therapy. thus, we performed a cross sectional study to reveal the association of oral microbe wi ... | 2015 | 26388671 |
| point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge. | periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the primary goals of periodontal treatment. however, periodontitis often progresses without noticeable symptoms, and many patients do not seek professional dental care until the periodontal destruction progre ... | 2015 | 26389079 |
| defining periodontal health. | assessment of the periodontium has relied exclusively on a variety of physical measurements (e.g., attachment level, probing depth, bone loss, mobility, recession, degree of inflammation, etc.) in relation to various case definitions of periodontal disease. periodontal health was often an afterthought and was simply defined as the absence of the signs and symptoms of a periodontal disease. accordingly, these strict and sometimes disparate definitions of periodontal disease have resulted in an id ... | 2015 | 26390888 |
| the detection of bana micro-organisms in adult periodontitis before and after scaling and root planing by bana-enzymatic™ test kit: an in vivo study. | many paraclinical methods are available today for an accurate assessment of the periodontal status prior and during the periodontal treatment. the microbial-enzymatic n-benzoyl-dl-arginine-2-napthylamide (bana) test is one of the modern alternatives to bacterial cultures. it detects the presence of three periodontal pathogens in the subgingival plaque (porphyromonas gingivalis, treponema denticola and tannerella forsythia). | 2015 | 26392688 |
| draft genome sequence of 'treponema phagedenis' strain v1, isolated from bovine digital dermatitis. | 'treponema phagedenis' is considered to be a key agent in the pathogenesis of bovine digital dermatitis, an infectious foot condition of economic and animal welfare importance. we hereby report the draft sequence of 't. phagedenis' strain v1. the draft genome assembly consists of 51 scaffolds comprising 3,129,551 bp and a gc-content of 39.9 %. putative pathogenicity related factors have been identified in the genome that can be used in future studies to gain insight into the pathogenic mechanism ... | 2015 | 26392840 |
| oral microbiome in chinese patients with aggressive periodontitis and their family members. | to investigate the microbiome composition in chinese patients with aggressive periodontitis (agp), and to compare the similarity of bacterial profiles between agp patients and their family members. | 2015 | 26412568 |
| dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. | diabetes and metabolic syndromes are chronic, devastating diseases with increasing prevalence. human pluripotent stem cells are gaining popularity in their usage for human in vitro disease modeling. with recent rapid advances in genome editing tools, these cells can now be genetically manipulated with relative ease to study how genes and gene variants contribute to diabetes and metabolic syndromes. | 2015 | 26413465 |
| protein biomarkers and microbial profiles in peri-implantitis. | the aim of the present investigation was to determine the profile of peri-implant crevicular fluid (picf) biomarkers combined with microbial profiles from implants with healthy peri-implant tissues and peri-implantitis to assess real-time disease activity. | 2016 | 26424287 |
| rheumatoid arthritis risk associated with periodontitis exposure: a nationwide, population-based cohort study. | the risk of periodontitis (pd) is increased in the patient group of rheumatoid arthritis (ra). ra and pd also shared some pathological mechanism. the aim of this study is to investigate the risk of ra associated with pd exposure. | 2015 | 26426533 |
| should antibiotics be prescribed to treat chronic periodontitis? | although scaling and root planing is a cost-effective approach for initial treatment of chronic periodontitis, it fails to eliminate subgingival pathogens and halt progressive attachment loss in some patients. adjunctive use of systemic antibiotics immediately after completion of scaling and root planing can enhance the degree of clinical attachment gain and probing depth reduction provided by nonsurgical periodontal treatment. this article discusses the rationale for prescribing adjunctive anti ... | 2015 | 26427574 |
| periodontal health status in patients treated with the invisalign(®) system and fixed orthodontic appliances: a 3 months clinical and microbiological evaluation. | the aim of this prospective study was to compare the periodontal health and the microbiological changes via real-time polymerase chain reaction (pcr) in patients treated with fixed orthodontic appliances and invisalign(®) system (align technology, santa clara, california). | 2015 | 26430371 |
| habitat fragmentation is associated to gut microbiota diversity of an endangered primate: implications for conservation. | the expansion of agriculture is shrinking pristine forest areas worldwide, jeopardizing the persistence of their wild inhabitants. the udzungwa red colobus monkey (procolobus gordonorum) is among the most threatened primate species in africa. primarily arboreal and highly sensitive to hunting and habitat destruction, they provide a critical model to understanding whether anthropogenic disturbance impacts gut microbiota diversity. we sampled seven social groups inhabiting two forests (disturbed v ... | 2015 | 26445280 |
| comparative analysis of calcium-binding myeloid-related protein-8/14 in saliva and serum of patients with periodontitis and healthy individuals. | this study aims to investigate calcium-binding myeloid-related protein (mrp)-8/14 in the saliva and serum of individuals with periodontitis and periodontally healthy individuals for the assessment of its role in the pathogenesis and clinical diagnosis of periodontitis. | 2016 | 26447749 |
| antibacterial activity of curcumin against periodontopathic bacteria. | curcumin is a polyphenol extracted from root of turmeric and known to possess multifunctional properties, including antibacterial activity. although previous studies have investigated the effects of curcumin on microorganisms, available knowledge on the effects of curcumin on periodontopathic bacteria is still limited. in this study, the antibacterial effect of curcumin on periodontopathic bacteria is investigated, particularly porphyromonas gingivalis. | 2016 | 26447754 |