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[Five years following of infections with extended-spectrum beta-lactamase producing enterobacteriaceae].Actually, epidemiology of extended-spectrum ß-lactamase (ESBL) producing enterobacteriaceae is increasing worldwide, especially in urinary tract infections (UTI). The objective of the study was to investigate the epidemiology of ESBL producers in a department of urology.201222196001
Apoprotein isolation and activation, and vibrational structure of the Helicobacter mustelae iron urease.The micro aerophilic pathogen Helicobacter mustelae synthesizes an oxygen-labile, iron-containing urease (UreA2B2) in addition to its standard nickel-containing enzyme (UreAB). An apoprotein form of the iron urease was prepared from ureA2B2-expressing recombinant Escherichia coli cells that were grown in minimal medium. Temperature-dependent circular dichroism measurements of holoprotein and apoprotein demonstrate an enhancement of thermal stability associated with the UreA2B2 metallocenter. In ...201122196017
Activity of Polymyxin B and the Novel Polymyxin Analogue CB-182,804 Against Contemporary Gram-Negative Pathogens in New York City.Multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa have become common in many regions, often requiring therapy with colistin or polymyxin B. An increase in resistance to these agents would render many infections untreatable. We tested the activity of polymyxin B and the novel polymyxin analogue CB-182,804 against over 5,000 recent Gram-negative clinical isolates from New York City, a region with a high prevalence of multiresistant strains. Over 96% of ...201122196342
multidrug-resistant gram-negative bacterial infections after liver transplantation - spectrum and risk factors.objectives: gram-negative bacilli infections, especially multidrug-resistant gram-negative bacilli infections, are the leading cause of high mortality after liver transplantation. this study sought to investigate the type of infection, infection rate, pathogenic spectrum, antibiotic-resistance profile, risk factors, and epidemiology of multidrug-resistant gram-negative bacterial infection. methods: a retrospective cohort study was conducted and data of 217 liver transplant patients receiving cad ...201122198738
Over-treatment of carbapenemase-producing Enterobacteriaceae.Objectives: To describe the treatment and outcomes of patients with carbapenemase-producing Enterobacteriaceae and evaluate whether these cases represented active infection requiring antibiotic therapy or colonization. Methods: Adult inpatients with carbapenemase-producing Enterobacteriaceae were retrospectively evaluated. Cases were classified as colonization versus infection by 2 infectious diseases physicians. Multiple cultures that grew in the same patient within a 2-week period were evaluat ...201122200121
partial excision of blakpc from tn4401 in carbapenem-resistant klebsiella pneumoniae.we describe a novel tn4401 variant (tn4401d) in epidemic klebsiella pneumoniae clone st258, from which a partial bla(kpc) fragment has been excised along with iskpn7 and a partial tnpa fragment. nested pcr experiments confirmed that this region can be removed from distinct tn4401 isoforms in both k. pneumoniae and escherichia coli. this study highlights that the region surrounding bla(kpc) is undergoing recombination, and that tn4401 itself is heterogeneous and highly plastic.201122203593
trends in the susceptibility of clinically important resistant bacteria to tigecycline: results from the tigecycline in-vitro surveillance in taiwan (tist), 2006-2010.the tigecycline in-vitro surveillance in taiwan (tist), a nationwide, prospective surveillance during 2006 to 2010, collected a total of 7,793 clinical isolates, including methicillin-resistant staphylococcus aureus (mrsa) (n=1,834), penicillin-resistant streptococcus pneumoniae (prsp) (n=423), vancomycin-resistant enterococci (vre) (n=219), extended-spectrum β-lactamase (esbl)-producing escherichia coli (n=1,141), esbl-producing klebsiella pneumoniae (n=1,330), acinetobacter baumannii (n=1,645) ...201122203598
Efficacy of Pivmecillinam for Treatment of Lower Urinary Tract Infection Caused by Extended-Spectrum ß-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae.To evaluate the clinical and bacteriological efficacy of pivmecillinam against lower urinary tract infection (UTI) caused by extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae, patients treated for lower UTI with pivmecillinam (n=8) were studied. Patients treated with nitrofurantoin (n=3) and trimethoprim (n=3) or a combination of these agents with pivmecillinam (n=3) were included as a control group. Antimicrobial susceptibility was determined with EUCAST ...201122204597
impact of inappropriate empirical antibiotic therapy on outcome of bacteremic adults visiting the ed.objectives: to investigate the clinical impact of inappropriate empirical antibiotics on patient outcome and determine the risk factors for mortality in bacteremic adults who visited the emergency department (ed). methods: bacteremic adults visiting the ed from january 2007 to june 2008 were identified retrospectively. demographic characteristics, clinical conditions, bacteremic pathogens, antimicrobial agents, and outcomes were determined from chart records. results: the total of 454 eligible b ...201122205015
emergence and risk factors of β-lactamase-mediated resistance to oxyimino-β-lactams in enterobacteriaceae isolates.we studied 193 enterobacteriaceae isolates presenting diminished susceptibility to oxyimino-cephalosporins recovered in a portuguese hospital (2004-2008). ctx-m-3 producers, firstly detected in portugal, were associated with a klebsiella pneumoniae microepidemic clone. production of ctx-m-type enzymes (ctx-m-1/-3/-9/-14/-15/-32), age ≥65 years, and nosocomial infection were risk factors for higher nonsusceptibility to oxyimino-β-lactams. cmy-2 and dha-1 β-lactamases were only identified in 1% of ...201122209509
Effects of arsenite stress on growth and proteome of Klebsiella pneumoniae.In the present study an arsenite, As(III), tolerating bacterium, MR4, was isolated from Mulla River Pune, India, capable of reducing arsenate to arsenite and identified as Klebsiella pneumoniae (HQ857583). Comparative proteomic analysis using two-dimensional gel electrophoresis (2-DGE) and matrix assisted laser desorption ionization-time of flight-time of flight (MALDI-TOF/TOF) was used to monitor the proteins undergoing changes in expression levels under 2.5mM As(III) stress. The 2-DGE proteome ...201122209886
cefotaxime for the detection of extended-spectrum β-lactamase or plasmid-mediated ampc β-lactamase and clinical characteristics of cefotaxime-non-susceptible escherichia coli and klebsiella pneumoniae bacteraemia.we investigated the performance of cefotaxime for the detection of extended-spectrum β-lactamase (esbl) or plasmid-mediated ampc β-lactamase (pampc) and the clinical characteristics of cefotaxime-non-susceptible escherichia coli or klebsiella pneumoniae (ctxns-ek) bacteraemia. all of the consecutive bloodstream isolates between 2005 and 2010 in a japanese university hospital were characterised using polymerase chain reaction (pcr). risk factors and outcomes of ctxns-ek were analysed by multivari ...201122210267
In vivo antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic.OBJECTIVES: To evaluate the in vivo antibacterial efficacy of chinfloxacin, a novel fluoroquinolone, in murine systemic and local infection models. METHODS: The efficacy of chinfloxacin in systemic infection was evaluated in a mouse peritonitis model using isolates of methicillin-susceptible Staphylococcus aureus (MSSA, n?=?3), methicillin-resistant Staphylococcus aureus (MRSA; n?=?1), penicillin-intermediate Streptococcus pneumoniae (PISP; n?=?1), penicillin-resistant S. pneumoniae (PRSP; n?=?2 ...201122210757
transient tlr activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice.mammals are colonized by an astronomical number of commensal microorganisms on their environmental exposed surfaces. these symbiotic species build up a complex community that aids their hosts in several physiological activities. we have shown that lack of intestinal microbiota is accompanied by a state of active il-10-mediated inflammatory hyporesponsiveness. the present study investigated whether the germfree state and its hyporesponsive phenotype alter host resistance to an infectious bacteria ...201122210917
role of primary bacterial contamination of a pulmonary homograft for ross operation: report of a case and review of the literature.in a 43-year-old female, ross operation was performed with annular reinforcement of the autograft and a cryo-fixed homograft that proved to be contaminated with enterobacter cloacae and klebsiella pneumoniae at the time of operation. clinical course was unremarkable, perhaps due to effective antibiotic prophylaxis and treatment. in the literature, little is known about intraoperative bacterial contamination and early endocarditis. the authors report what they believe is the second reported case. ...201222215504
prevalence of bacterial pathogens in aseer region, kingdom of saudi arabia: emphasis on antimicrobial susceptibility of staphylococcus aureus.this short study aims to determine the prevalence of various bacterial pathogens causing infections in the aseer regions, and to also assess the distribution of staphylococcus aureus in relation to different body sites as well as their in vitro antimicrobial susceptibility profile.201122216389
antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in south african hospitals (smart study 2004-2009): impact of the new carbapenem breakpoints.abstract background: the study for monitoring antimicrobial resistance trends (smart) follows trends in resistance among aerobic and facultative anaerobic gram-negative bacilli (gnb) isolated from complicated intra-abdominal infections (ciais) in patients around the world. methods: during 2004-2009, three centralized clinical microbiology laboratories serving 59 private hospitals in three large south african cities collected 1,218 gnb from complicated intra-abdominal infections (ciais) and t ...201222220506
development of an optimized random amplified polymorphic dna protocol for fingerprinting of klebsiella pneumoniae.aims:  to develop an optimized random amplified polymorphic dna (rapd) protocol for fingerprinting clinical isolates of klebsiella pneumoniae. methods and results:  employing factorial design of experiments, repeatable amplification patterns were obtained for 54 nosocomial isolates using 1 μmol 1(-1) primer, 4 mmol 1(-1) mgcl(2) , 0·4 mmol 1(-1) dntps, 2·5 u taq dna polymerase and 90 ng dna template in a total volume of 25 μl. the optimum thermocycling program was: initial denaturation at 94° ...201222220979
a case of oxa-48 carbapenemase-producing klebsiella pneumoniae in a patient transferred to slovenia from libya, november 2011. 201122221496
prevalence of plasmid mediated bla(tem-1) and bla(ctx-m-15) type extended spectrum beta-lactamases in patients with sepsis.to characterize the bacterial pathogens in patients having gram negative septicaemia. further, to evaluate the antimicrobial resistance and underlying molecular mechanisms in these strains.201222221749
chemical compositions of the essential oils of aerial parts of chamaemelum mixtum (l.) alloni.the chemical compositions of the aerial parts essential oils of chamaemelum mixtum (l.) alloni from corsica and sardinia were investigated employing gas chromatography and gas chromatography/mass spectrometry. the structure of (z)-heptadeca-9,16-dien-7-one, a natural compound not previously described, was elucidated by gas chromatography/mass spectrometry (electron impact and chemical ionization) and one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy. the variation in ch ...201222225420
study of plasmid-mediated extended-spectrum β-lactamase-producing strains of enterobacteriaceae, isolated from diabetic foot infections in a north indian tertiary-care hospital.abstract aim: this study evaluated the incidence and factors responsible for plasmid-mediated extended-spectrum β-lactamase (esbl) infection among patients with diabetic foot ulcer (dfu). subjects and methods: a prospective study was conducted on 162 dfu inpatients treated in a multidisciplinary-based diabetes and endocrinology center at jawaharlal nehru medical college of aligarh muslim university, aligarh, india, during the period of december 2008-march 2011. detailed history and patient's ...201222225456
significance of perioperative infection in survival of patients with ovarian cancer.perioperative infectious diseases comprise some of the most common causes of surgical mortality in women with ovarian cancer. this study was aimed to evaluate the significance of perioperative infections in survival of patients with ovarian cancer.201222228425
functional analysis of cus operon promoter of klebsiella pneumoniae using e. coli lacz assay.the transcriptional fusion of reporter lacz gene with cusrs regulatory promoter of cus operon of klebsiella pneumoniae enabled us to analyze the inductive effect of copper on promoter via lacz assay. the stimulus response curve of promoter to a range of copper metal concentrations indicated a normal sigmoidal response profile with apparent hill coefficient 1.0. there was a positive correlation of promoter response to the increasing concentration of copper in the medium. ac(50) value of copper wa ...201122230226
a randomised, double-blind trial comparing ceftobiprole medocaril with ceftriaxone with or without linezolid for the treatment of patients with community-acquired pneumonia requiring hospitalisation.community-acquired pneumonia (cap) is a serious infection requiring hospitalisation in 20% of cases. the novel cephalosporin ceftobiprole has microbiological activity against the major bacterial pathogens causing cap, including streptococcus pneumoniae, haemophilus influenzae and klebsiella pneumoniae, as well as against staphylococcus aureus, including meticillin-resistant s. aureus (mrsa). this was a multicentre, double-blind study in which 706 patients with cap severe enough to require hospit ...201222230331
production of 2,3-butanediol from acid hydrolysates of jatropha hulls with klebsiella oxytoca.jatropha hulls were successfully for the first time used as raw materials for the production of 2,3-butanediol via dilute sulfuric acid hydrolysis and fermentation with klebsiella oxytoca. two-step hydrolysis was used to effectively hydrolyze the hulls at 150°c after pretreatment. in the first-step, hemicellulose was hydrolyzed under mild conditions (0.5h, 1.5% acid) to avoid secondary decomposition. the remained cellulose was further hydrolyzed in the second-step under severer conditions (1h, 4 ...201122230777
in vitro potential of equine defa1 and ecath1 as alternative antimicrobial drugs in rhodococcosis treatment.rhodococcus equi, the causal agent of rhodococcosis, is a severe pathogen of foals but also of immunodeficient humans causing bronchopneumonia. the pathogen is often found together with klebsiella pneumoniae or streptococcus zooepidemicus in foals. of great concern is the fact that some r. equi strains are already resistant to commonly used antibiotics. in the present study, we evaluated the in vitro potential of two equine antimicrobial peptides (amps), ecath1 and defa1, as new drugs against r. ...201222232283
bronchoscopic findings in children with chronic wet cough.objectives:protracted bacterial bronchitis is defined as the presence of more than 4 weeks of chronic wet cough that resolves with appropriate antibiotic therapy, in the absence of alternative diagnoses. the diagnosis of protracted bacterial bronchitis is not readily accepted within the pediatric community, however, and data on the incidence of bacterial bronchitis in children are deficient. the objective of this study was to determine the frequency of bacterial bronchitis in children with chron ...201222232311
etiology of acute, non-malaria, febrile illnesses in jayapura, northeastern papua, indonesia.abstract. we conducted a prospective, inpatient fever study in malaria-endemic papua, indonesia to determine non-malaria fever etiologies. investigations included malaria blood films, blood culture, paired serologic samples analysis for dengue, japanese encephalitis, leptospirosis, scrub typhus, murine typhus, and spotted fever group rickettsia. during 1997-2000, 226 patients (127 males and 99 females) 1-80 years of age (median age = 25 years) were enrolled. positive blood cultures (n = 34, 15%) ...201222232450
klebsiella pneumoniae related community-acquired acute lower respiratory infections in cambodia: clinical characteristics and treatment.abstract: background: in many asian countries, klebsiella pneumoniae (kp) is the second pathogen responsible for community-acquired pneumonia. yet, very little is known about kp etiology in alri in cambodia, a country that has one of the weakest medical infrastructures in the region. we present here the first clinico-radiological description of kp community-acquired alri in hospitalized cambodian patients. methods: through alri surveillance in two provincial hospitals, kp was isolated from sput ...201222233322
different potency of bacterial antigens, both tlr2 and tlr4 ligands, in stimulating mature mast cells to cysteinyl leukotriene synthesis.the aim of study was to compare the potency of different bacterial antigens to induce rat mature mast cell to cysteinyl leukotriene (cyslt) generation. we examined toll-like receptor (tlr)2 agonists, i.e. lipoteichoic acid (lta) staphylococcus faecalis, streptococcus pyogenes, bacillus subtilis and staphylococcus aureus, lipoarabinomannan (lam) mycobacterium smegmatis, peptydoglican (pgn) staphylococcus aureus, as well as tlr4 agonists, i.e. lipopolysaccharide (lps) klebsiella pneumoniae, pseudo ...201222233438
klebsiella pneumoniae septic wrist arthritis successfully treated with ertapenem and levofloxacin. 201122233826
bla (kpc) and rmtb on a single plasmid in enterobacter amnigenus and klebsiella pneumoniae isolates from the same patient.enterobacter amnigenus (ea76) and klebsiella pneumoniae (kp76) isolates with multidrug-resistant (mdr) patterns were identified from the same patient in the neurosurgery department of our hospital. an outbreak of mdr k. pneumoniae had also occurred in this department. to characterize the resistance mechanism and molecular epidemiology of these isolates, sequential experiments including antimicrobial susceptibility testing, polymerase chain reaction (pcr), plasmid analysis, pulsed field gel elect ...201222237458
on the evolution of the sexually transmitted bacteria haemophilus ducreyi and klebsiella granulomatis.haemophilus ducreyi and klebsiella (calymmatobacterium) granulomatis are sexually transmitted bacteria that cause characteristic, persisting ulceration on external genitals called chancroid and granuloma inguinale, respectively. those ulcers are endemic in developing countries or exist, as does granuloma inguinale, only in some geographic "hot spots."h. ducreyi is placed in the genus haemophilus (family pasteurellacae); however, this phylogenetic position is not obvious. the multiple ways in whi ...201122239475
mitochondrial dna 8993t>g mutation in a child with ornithine transcarbamylase deficiency and leigh syndrome: an unexpected association.mc, female, is the third child of a nonconsanguineous portuguese couple, born after an uneventful pregnancy and delivery. a positive family history of ornithine transcarbamylase deficiency, associated with the ivs8+1 g>a mutation in the ornithine transcarbamylase gene, prompted prenatal diagnosis with identification of the same mutation in the proband. during an episode of klebsiella pneumoniae sepsis at 1.5 months of age, lactic acidosis and moderate hyperammonemia were noticed. after a short a ...201222241703
one-day point prevalence of emerging bacterial pathogens in four secondary and five tertiary care german hospitals - results from a pilot study of the german society for hospital hygiene (deutsche gesellschaft für krankenhaushygiene, dgkh).objective: data on the prevalence of emerging bacterial pathogens like extended-spectrum-lactamase-building (esbl) gram negative organisms, multiresistant pseudomonas and acinetobacter species or toxin-building clostridium difficile in german hospitals are sparse. to provide data for different regions in germany, a one-day point prevalence study with five tertiary care hospitals and four secondary care hospitals was conducted on the 10(th) of february 2010.method: for participating hospitals, th ...201122242101
isolation and characterization of lipase-producing bacteria in the intestine of the silkworm, bombyx mori, reared on different forage.abstract the silkworm, bombyx mori l. (lepidoptera: bombycidae), an oligophagous insect that mainly feeds on mulberry leaves, is susceptible to entomopathogen infection when reared with tricuspid cudrania leaves. a total of 56 dominant bacterial strains, classified into 12 phylotypes based on bacteriological properties and analysis of 16s rrna genes, were isolated from the intestine of the fourth and fifth instar silkworm larvae. ten and seven phylotypes exist in the intestine of the silkworm ...201122243438
characterization of a single-stranded dna-binding protein from klebsiella pneumoniae: mutation at either arg73 or ser76 causes a less cooperative complex on dna.single-stranded dna-binding protein (ssb) plays an important role in dna metabolism, such as in processes like dna replication, repair and recombination, and is essential for cell survival. here, we characterized the ssdna-binding properties of klebsiella pneumoniae ssb (kpssb) by using fluorescence-quenching measurements, electrophoretic mobility shift analysis (emsa) and site-directed mutagenesis. analysis of purified kpssb by gel-filtration chromatography showed a stable tetramer in solution. ...201222244199
the role of nutrients in the biodegradation of 2,4,6-trinitrotoluene in liquid and soil.the widely used explosive 2,4,6-trinitrotoluene (tnt) has residues that are potentially explosive, toxic, and mutagenic. tnt and other explosives can be degraded by microorganisms; however, biostimulation is needed for process efficiency. to investigate the effectiveness of using biostimulation to degrade tnt, we added varying concentrations of a nutrient amendment consisting of inorganic salts, plant extracts, and molasses to soil and liquid media. for the inoculum we used a consortium of bacte ...201222245864
antimicrobial resistance of bacterial agents of the upper respiratory tract in south indian population.the study was aimed at determining bacterial agents of the upper respiratory tract and the susceptibility patterns of isolates to antibiotics. the throat swab samples from 250 patients suspected of upper respiratory tract infection (urti) were obtained from the general medicine outpatient department of a rural health centre of rajah muthiah medical college and hospital (rmmc and h), annamalai university, chidambaram, tamilnadu, india and inoculated in the culture medium. the bacterial infection ...201022247847
synthesis and anti-microbial screening of novel schiff bases of 3-amino-2-methyl quinazolin 4-(3h)-one.in the present study, novel schiff bases were synthesized by condensation of 3-amino-2-methyl quinazolin-4-(3h)-ones with different aromatic aldehydes. the 3-amino-2-methyl quinazolin-4-(3h)-one was synthesized from anthranilic acid via the 2-methyl benzoxazin-4-one. the chemical structures of the synthesized compounds were confirmed by means of infrared (ir), (1)h-nmr, (13)c-nmr, mass spectral, and elemental analysis. these compounds were screened for anti-bacterial (staphylococcus aureus atcc ...201022247864
faecal carriage of extended-spectrum β-lactamase-producing enterobacteriaceae among humans in java, indonesia, in 2001-2002.objective  to characterise commensal escherichia coli and other enterobacteriaceae with reduced susceptibility to cefotaxime that were collected in a large survey carried out among 3995 patients and healthy persons in two urban regions on java, indonesia, in 2001-2002. methods  the putative extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae were analysed using double-disk synergy tests, isoelectric focusing, pcr assays, dna sequencing, and pulsed-field gel electrophoresis (pfge). ...201222248076
characterization of carbapenem-nonsusceptible klebsiella pneumoniae bloodstream isolates at a taiwanese hospital: clinical impacts of lowered breakpoints for carbapenems.this study was conducted in order to characterize carbapenem-nonsusceptible klebsiella pneumoniae isolates and to evaluate the impacts of recently lowered interpretative breakpoints for carbapenems for enterobacteriaceae. among 152 k. pneumoniae bloodstream isolates suspected as ampc or extended-spectrum β-lactamase (esbl) producers, 58 (38.2%) isolates were currently interpreted as nonsusceptible to ertapenem, imipenem, or meropenem, and 42 (72.4%) of them were categorized as carbapenem-suscept ...201222249422
coastal seawater bacteria harbor a large reservoir of plasmid-mediated quinolone resistance determinants in jiaozhou bay, china.diversity and prevalence of plasmid-mediated quinolone resistance determinants were investigated in environmental bacteria isolated from surface seawater of jiaozhou bay, china. five qnr gene alleles were identified in 34 isolates by pcr amplification, including qnra3 gene in a shewanella algae isolate, qnrb9 gene in a citrobacter freundii isolate, qnrd gene in 22 proteus vulgaris isolates, qnrs1 gene in 1 enterobacter sp. and 4 klebsiella spp. isolates, and qnrs2 gene in 1 pseudomonas sp. and 4 ...201222252223
chemometric modeling and two-dimensional fluorescence analysis of bioprocess with a new strain of klebsiella pneumoniae to convert residual glycerol into 1,3-propanediol.the goal of this study was to show that the metabolism of klebsiella pneumoniae under different aeration strategies could be monitored and predicted by the application of chemometric models and fluorescence spectroscopy. multi-wavelength fluorescence was applied to the on-line monitoring of process parameters for k. pneumoniae cultivations. differences observed in spectra collected under aerobiosis and anaerobiosis can be explained by the different metabolic states of the ce ...201222252443
klebsiella pneumoniae st258 producing kpc-3 identified in italy carries novel plasmids and ompk36/ompk35 porin variants.a carbapenemase resistant klebsiella pneumoniae strain, clone st258 producing kpc-3 was fully characterized. the entire plasmid content was investigated, identifying plasmids of the incfii(k) (two of them similar to pkpqil and pkpn3, respectively), incx and cole types, encoding for a formidable set of resistance genes against toxic compounds, metals and antimicrobial drugs and a novel iron(iii) uptake system.201222252815
nosocomial clustering of ndm-1-producing klebsiella pneumoniae sequence type 340 in four patients at a korean tertiary care hospital.in november 2010, ndm-1-producing klebsiella pneumoniae (ndmkp) was identified from four patients stayed for 21 to 205 days in a tertiary care hospital with no travelling history abroad, which was first time in korea. all were st340 and had nearly identical xbai-pfge patterns. the bla(ndm-1)-carrying plasmids were inc/rep n group with a variable size of 50-200 kb. these findings suggest that ndmkp had already been introduced into korea before this clustering found.201222259206
phenotypic screening of carbapenemases and associated beta-lactamases in carbapenem-resistant enterobacteriaceae.dissemination of carbapenem resistance among enterobacteriaceae poses a considerable threat to public health. carbapenemase gene detection by molecular methods is the gold standard but is only available in few laboratories. the aim of this study was to test phenotypic methods for the detection of metallo-β-lactamase (mbl)- or klebsiella pneumoniae carbapenemase (kpc)-producing enterobacteriaceae and associated mechanisms of beta-lactam resistance against a panel of 30 genotypically characterized ...201222259214
seroepidemiology of klebsiella pneumoniae colonizing the intestinal tract of healthy chinese and overseas chinese adults in asian countries.abstract: background: capsular serotypes k1 and k2 of klebsiella pneumoniae are thought to the major virulence determinants responsible for liver abscess. the intestine is one of the major reservoirs of k. pneumoniae, and epidemiological studies have suggested that the majority of k. pneumoniae infections are preceded by colonization of the gastrointestinal tract. the possibility of fecal-oral transmission in liver abscess has been raised on the basis of molecular typing of isolates. data on th ...201222260182
french results of the aresc study: clinical aspects and epidemiology of antimicrobial resistance in female patients with cystitis. implications for empiric therapy.objective: uncomplicated cystitis is one of the most frequent community infections. we report the french results of the international aresc study on the clinical aspects, epidemiology, and antimicrobial susceptibility of uropathogens. patient and methods: female patients between 18 and 65 years of age, with symptoms of uncomplicated cystitis, were investigated clinically with urinalysis and urine culture. uropathogens were identified and their susceptibility was tested with nine antimicrobials. ...201222264668
antimicrobial activity of ulopterol isolated from toddalia asiatica (l.) lam.: a traditional medicinal plant.aim of the study: the leaves of toddalia asiatica (l.) lam. (rutaceae) are widely used in folk medicine in india to treat various ailments. in our earlier communication we have reported the antimicrobial study on the various extracts of the leaves and the isolation and identification of flindersine, a quinolone alkaloid as the major active principle. in the present study, we report the antibacterial and antifungal activities of ulopterol, a coumarin isolated as another major active antimicrobial ...201222265751
prevalence of antibiotic resistance in fecal flora of patients undergoing transrectal ultrasound-guided prostate biopsy in thailand.objective: the objective of this study was to determine the prevalence of antibiotic resistance in fecal flora of patients undergoing transrectal ultrasound-guided needle biopsy of the prostate (trusb) and the factors associated with such antibiotic resistance. methods: a prospective study of patients undergoing trusb was conducted. rectal swabs were performed and sent for cultures and antibiotic susceptibility testing before trusb. clinical characteristics were determined. results: 287 gram-neg ...201222269856
characterization of a novel klebsiella pneumoniae sequence type 476 carrying both bla (kpc-2) and bla (imp-4).carbapenemase-producing klebsiella pneumoniae has recently spread rapidly throughout china. in this study, we characterized a carbapenem-resistant k. pneumoniae isolate that produced both kpc-2 and imp-4 type carbapenemases. a clinical isolate of k. pneumoniae, resistant to both meropenem and imipenem, was recovered from a urine sample. antibiotic susceptibility was determined using the broth microdilution method and etest (biomérieux, france). pulsed-field gel electrophoresis and multilocus seq ...201222271301
piperacillin-tazobactam as an initial empirical therapy of bacteremia caused by extended-spectrum β-lactamase-producing escherichia coli and klebsiella pneumoniae. 201222274414
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