Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the intracellular life of chlamydiae. | the ability to cause persistent infection is one of the major characteristics of all chlamydial species in their appropriate hosts. persistent infection with chlamydia trachomatis and chlamydia pneumoniae has been implicated in the pathogenesis of many chronic diseases, some initially not thought to be infectious, including pelvic inflammatory disease, arthritis, asthma, and atherosclerosis. chlamydiae have a unique developmental cycle with morphologically distinct infectious and reproductive fo ... | 2002 | 12491229 |
| microbiology of newer fluoroquinolones: focus on respiratory pathogens. | community-acquired pneumonia, acute exacerbations of chronic bronchitis, and acute sinusitis are among the most common bacterial infections encountered in clinical practice. pathogens frequently associated with these infections include streptococcus pneumoniae, hemophilus influenzae, moraxella catarrhalis, chlamydia pneumoniae, legionella pneumophila, and mycoplasma pneumoniae. unfortunately, resistance to antimicrobials commonly used for the treatment of these infections is increasing, limiting ... | 2002 | 12493166 |
| chlamydia pneumoniae in elderly patients with stroke (c-peps): a case-control study on the seroprevalence of chlamydia pneumoniae in elderly patients with acute cerebrovascular disease. | multiple studies have suggested an association between chlamydia pneumoniae infection and atherosclerotic vascular disease. we investigated whether serological markers of c. pneumoniae infection were associated with acute stroke or transient ischaemic attack (tia), exclusively in elderly patients. | 2003 | 12499705 |
| atypical pathogens in adult patients admitted with community-acquired pneumonia in korea. | this study examined the prevalence of atypical pathogens causing community-acquired pneumonia (cap) in korea. we collected sera and clinical data for a period of 1 year for the adult patients consecutively admitted to chunchon sacred heart hospital with cap. the diagnosis was made using serologic methods to detect antibodies for mycoplasma pneumoniae, chlamydia pneumoniae, legionella spp., chlamydia psittaci, and coxiella burnetii. among 81 recruited patients, c. pneumoniae (n = 10, 12.3%) was t ... | 2002 | 12501255 |
| [chlamydia infections in children with acquired cicatricial laryngeal and tracheal stenosis]. | the examination for chlamydial infection was carried out in 49 children aged from 1 year 10 months to 15 years (mean age 9 years 6 months +/- 3 years 8 months) with laryngotracheal cicatricial stenosis (cs) provoked by long nasotracheal intubation. antibodies to c. pneumoniae in diagnostically significant titers were detected in 13 of 49 children (26.5%), to c. trachomatis--in 1 patient who had both infections. all the infected patients except the latter carried tracheal canules or were decanula ... | 2002 | 12501774 |
| different heat shock protein 60 species share pro-inflammatory activity but not binding sites on macrophages. | in a study of seven different hsp60 species, we found that all mammalian and microbial proteins shared the property of eliciting an inflammatory response in mouse macrophages. in all cases, tnfalpha production was induced by 0.1 microm concentrations of hsp60. however, the different hsp60 preparations did not compete for the same binding site. the binding of fluorescence-labeled human hsp60 was inhibited by excess unlabeled human, rat or mouse hsp60, but not hamster, escherichia coli, chlamydia ... | 2003 | 12505167 |
| cutaneous vasculitis and reactive arthritis following respiratory infection due to chlamydia pneumoniae: report of a case. | unlike chlamydia trachomatis and c. psittaci, the association of c. pneumoniae infection with immunological complications, such as reactive arthritis (rea) or erythema nodosum (en) has been rarely reported. here we present the case history of a patient with c. pneumoniae community acquired pneumonia (cap) who subsequently developed a rea and a cutaneous vasculitis. a 45-year-old hla b27 negative male developed an asymmetric and additive arthritis and a cutaneous leukocytoclastic vasculitis with ... | 2002 | 12508779 |
| chlamydia pneumoniae dna in peripheral blood mononuclear cells in dialysis patients, renal transplant recipients and healthy controls. | it has been suggested that infection with chlamydia pneumoniae plays a role in the development and maintenance of atherosclerosis based on differences in the prevalence of antibodies against chlamydia pneumoniae in patients with and without atherosclerotic lesions and on the presence of bacteria in atherosclerotic lesions. it is well known that patients undergoing chronic dialysis treatment and renal transplant recipients have a considerably increased risk of cardiovascular disease. in this stud ... | 2002 | 12512740 |
| chlamydia pneumoniae and the heart: impact of diagnostic methods. | 2002 | 12520645 | |
| polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. | gram-negative bacterial infection, namely chlamydia pneumoniae has been recently discussed as a risk factor for myocardial infarction. the lipopolysaccharide-binding protein (lbp) and the bactericidal/permeability-increasing protein (bpi) play a role in the processes leading to recognition and neutralisation of the chlamydia pneumoniae and their endotoxins lipopolysaccharides (lps). lps interact with plasma lbp, and lbp-lps complex activates monocytes/macrophages, which can influence the atheros ... | 2002 | 12521224 |
| measurement of chlamydia pneumoniae-specific immunoglobulin a (iga) antibodies by the microimmunofluorescence (mif) method: comparison of seven fluorescein-labeled anti-human iga conjugates in an in-house mif test using one commercial mif and one enzyme immunoassay kit. | for the serological diagnosis of acute chlamydia pneumoniae infection, the microimmunofluorescence (mif) test is the most commonly used method and also the "gold standard" for the measurement of immunoglobulin g (igg) and igm antibodies. the role of iga antibodies in diagnosis has not been established. commercially available fluorescein-labeled anti-human iga conjugates have not been systematically compared to each other, and this situation may cause considerable variations in iga results. there ... | 2003 | 12522032 |
| characterization of the humoral immune response to chlamydia outer membrane protein 2 in chlamydial infection. | detection of antibodies to an outer membrane protein 2 (omp2) by enzyme-linked immunosorbent assay (elisa) by using either the chlamydia trachomatis- or the chlamydia pneumoniae-specific protein was investigated. omp2 is an immunodominant antigen giving rise to antibody responses in humans infected with different c. trachomatis serovars (a to c and d to k) or with c. pneumoniae, which could be detected by omp2 elisa. omp2 elisa is not species specific, but antibody titers were usually higher on ... | 2003 | 12522047 |
| [multisystemic severe infection with chlamydia pneumoniae]. | chlamydia pneumoniae (cp) is responsible for 8-10% of community acquired pneumonia. however, multiorgan disease is rare and the association with a cutaneous vasculitis has only been described once. we report a case of serious systemic cp infection with capillary leak syndrome and cutaneus vasculitis who was treated successfully with levofloxacin. | 2002 | 12522935 |
| role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: a prospective study in the nord-pas de calais region (france). | we studied the role of viruses and atypical bacteria in children hospitalized with exacerbated asthma by a prospective study of children with acute asthma admitted to the department of pediatrics in lille, and to 15 hospitals in the nord-pas de calais region, from october 1, 1998-june 30, 1999. we included children aged 2-16 years with active asthma, defined as three or more recurrent episodes of reversible wheezing. the severity of asthma and of asthmatic exacerbations was recorded. immunofluor ... | 2003 | 12526066 |
| upregulation of extracellular matrix metalloproteinase inducer (emmprin) and gelatinases in human atherosclerosis infected with chlamydia pneumoniae: the potential role of chlamydia pneumoniae infection in the progression of atherosclerosis. | chlamydia pneumoniae infection implicated as an important etiologic factor of atherosclerosis, especially in coronary artery disease (cad), was found in vitro to be associated with the induction of matrix metalloproteinases (mmps). an extracellular matrix metalloproteinase inducer (emmprin)/ membrane-type 1 matrix metalloproteinase (mt1-mmp) system which induces and activates mmps, is suggested to be functional and were upregulated in the failing myocardium. however, the upstream regulation of m ... | 2002 | 12526080 |
| enterovirus, mycoplasma and other infections as predictors for myocardial infarction. | to study antibodies against five infectious agents for their prediction of major coronary events in men with and without evidence of coronary heart disease at baseline. | 2002 | 12528760 |
| infection of murine precision cut lung slices (pcls) with respiratory syncytial virus (rsv) and chlamydophila pneumoniae using the krumdieck technique. | the krumdieck technique allows the investigation of the so-called precision cut lung slices (pcls) with a special microtome. it is thus possible to evaluate morphologic changes over a longer period of time using only a small group of animals. chlamydophila pneumoniae (cp) and respiratory syncytial virus (rsv) proved to be important causes of pneumonia, rhinitis and exacerbations of asthma bronchiale, as well as of lower respiratory tract infections in young children. pcls should be tested for th ... | 2002 | 12530578 |
| dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistance. | the global emergence of antibacterial resistance among common and atypical respiratory pathogens in the last decade necessitates the strategic application of antibacterial agents. the use of bactericidal rather than bacteriostatic agents as first-line therapy is recommended because the eradication of microorganisms serves to curtail, although not avoid, the development of bacterial resistance. bactericidal activity is achieved with specific classes of antimicrobial agents as well as by combinati ... | 2003 | 12533275 |
| hyperhomocysteinemia is linked with c. pneumoniae igg seropositivity in coronary artery disease and peripheral arterial occlusive disease. | 2003 | 12535757 | |
| sensitivity and specificity of three new commercially available chlamydia trachomatis tests. | in order to determine the value of new chlamydia trachomatis (ct) specific tests for routine serological diagnosis of ct infections, we evaluated several commercially available assays (c. trachomatis enzyme immunoassay (eia), labsystems (ctl); seroct, savyon (cts); pelisa, medac (ctmp)) in various study populations. the prevalence of c. trachomatis-specific iga antibodies in a blood donor population (n = 443) as determined by the peptide based tests ctl, the cts and the ctmp was 5%, while for ig ... | 2002 | 12537721 |
| chlamydiae host cell interactions revealed using dna microarrays. | chlamydiae are obligate intracellular bacterial parasites that infect eukaryotic cells and live their entire life cycle within a cytoplasmic vacuole or inclusion. we have employed cdna microarray and conventional biological approaches to study the pathogen-host cell interaction during c. pneumoniae infection of eukaryotic cells. two host cell signaling pathways, mek/erk and pi 3-kinase/akt, were activated within 5 and 20 minutes, respectively, following infection with chlamydiae. pharmacological ... | 2002 | 12538165 |
| multiple infections and subsequent cardiovascular events in the heart outcomes prevention evaluation (hope) study. | limited prospective epidemiological data are available on the relation between exposure to chlamydia pneumoniae, helicobacter pylori, cytomegalovirus (cmv), and hepatitis a virus (hav), individually or as a total pathogen score, and human cardiovascular (cv) disease. | 2003 | 12538424 |
| induction of proinflammatory cytokines in human lung epithelial cells during chlamydia pneumoniae infection. | chlamydia pneumoniae is an obligate intracellular human pathogen that causes acute respiratory diseases such as pneumonia and bronchitis. previous studies have established that c. pneumoniae can induce cytokines in mouse and/or human cells, but little information is available on the cytokine response of respiratory epithelial cells, a first line of infection. in this study, heparin treatment of c. pneumoniae significantly reduced its ability to induce interleukin 8 (il-8) and tumor necrosis fact ... | 2003 | 12540537 |
| methodologies and cell lines used for antimicrobial susceptibility testing of chlamydia spp. | in vitro susceptibility testing was performed on strains of chlamydia trachomatis, chlamydia pneumoniae, and chlamydia psittaci under various conditions, including the cell line utilized, the time between infection and the addition of an antimicrobial, the concentration of inoculum, and the effect of multiple passage on the minimal chlamydicidal concentrations for the antibiotics doxycycline, azithromycin, erythromycin, ofloxacin, and tetracycline. with macrolides, the mic varied depending upon ... | 2003 | 12543671 |
| chlamydia pneumoniae and acute chest syndrome in patients with sickle cell disease. | purpose few studies address the association of chlamydia pneumoniae infection with pulmonary disease and outcome in patients with underlying pathology such as sickle cell disease (scd). scd patients are susceptible to the pulmonary disorder known as acute chest syndrome (acs), where the etiology remains ill defined. the purpose of this study was to analyze the clinical course and outcome of c. pneumoniae-associated acs among scd patients as part of the national acute chest syndrome study. | 2003 | 12544773 |
| qsyp peptide sequence is selected from phage display libraries by bovine igg contaminants in monoclonal antibody preparations. | a consensus peptide sequence, qsyp, appears as an artifact during the mapping of monoclonal antibodies (mabs) using a random peptide phage display library. phage bearing this qsyp sequence were independently selected by four different laboratories screening separate mab preparations with the same phage library. in each case, the qsyp sequence was selected in addition to a consensus sequence specific to the mab. phage that displayed the qsyp sequence were not bound by the mab of interest, but rat ... | 2003 | 12545550 |
| cell-to-cell contact of human monocytes with infected arterial smooth-muscle cells enhances growth of chlamydia pneumoniae. | chlamydia pneumoniae can infect arterial cells. it has been shown that coculture of human monocytes (u937) and endothelial cells promotes infection of c. pneumoniae in endothelial cells and that the enhancement was mediated by a soluble factor (insulin-like growth factor 2) secreted by monocytes. in this study, it is shown that coculture of monocytes with c. pneumoniae enhances infection of c. pneumoniae in arterial smooth-muscle cells 5.3-fold at a monocyte-to-smooth-muscle cell ratio of 5. how ... | 2003 | 12552427 |
| [atherosclerosis and chlamydia pneumoniae]. | chlamydia pneumoniae could be associated with the risk of developing atherosclerosis and an increased risk of thromboembolic complications. however, the evidence of an association seems to be declining and there is no evidence of causality. the effect of antibiotic treatment in cardiovascular disease has been explored in epidemiologic studies and in randomised controlled trials. data suggest a protective but short-lasting effect of macrolide antibiotics on cardiovascular disease. the effect coul ... | 2002 | 12553110 |
| development potential of rifalazil. | rifalazil represents a new generation of ansamycins that contain a unique four-ring structure. originally rifalazil was developed as a therapeutic agent to replace rifampin as part of a multiple drug regimen in the treatment of tuberculosis. as a result of its superior antimicrobial activity and high intracellular levels, rifalazil has potential to treat indications caused by the intracellular pathogen, chlamydia trachomatis, which causes non-gonococcal urethritis and cervicitis, often leading t ... | 2003 | 12556219 |
| a review of macrolide treatment of atherosclerosis and abdominal aortic aneurysms. | seroepidemiological studies have shown an association between chlamydia pneumoniae and atherosclerosis, the risk of acute myocardial infarction and abdominal aortic aneurysms (aaa). several studies have detected c. pneumoniae in atherosclerotic lesions from coronary and carotid arteries, in aaa, and in sclerotic aortic valves. however, culturing of c. pneumoniae is difficult and has seldomly succeeded from atherosclerotic lesions. thus, the pathogenicity is unknown, and the significance of detec ... | 2003 | 12570733 |
| increased prevalence of chlamydophila pneumoniae but not epstein-barr antibodies in essential hypertensives. | conflicting data exist regarding the relationship between chlamydophila pneunoniae (c. pneumoniae) and hypertension. in this study, both c. pneumoniae igg and iga titres and epstein-barr virus antibody levels were measured in 146 sustained hypertensives defined by 24 h ambulatory blood pressure monitoring (abpm) and 54 normotensives. c. pneumoniae antibodies were measured by microimmunofluorescence test. igg > or = 80 and iga > or = 40 were defined as elevated antibody titres. epstein-barr antib ... | 2003 | 12571613 |
| [etiology of community-acquired pneumonia among adult patients in japan]. | to clarify the etiology of community-acquired pneumonia (cap) in japan, the causative pathogens were prospectively investigated in adult patients admitted to kurashiki central hospital. the microbiological diagnosis was based on the results of quantitative sputum culture, blood culture, and other invasive procedures, including transthoracic needle aspiration or bronchoscopic examination. five hundred fifty-two episodes of cap in 540 patients were admitted between july 1994 and june 1999. causati ... | 2000 | 12572085 |
| [the role of atypical pathogen: mycoplasma pneumoniae and chlamydia pneumoniae in the acute respiratory infection in childhood]. | the recent microbiological advance has revealed the importance of atypical pathogens such as mycoplasma pneumoniae, chlamydia pneumoniae, and legionella pneumophila as common causes of acute bronchitis and community-acquired pneumonia. we found a third of community-acquired pneumonia in childhood were caused by m. pneumoniae and c. pneumoniae like western countries and there were many dual infections than expected. therefore we have to treat patients with community-acquired pneumonia in always t ... | 2000 | 12572086 |
| lipoprotein(a), chlamydia pneumoniae, leptin and tissue plasminogen activator as risk markers for valvular aortic stenosis. | the aim of the present study was to identify risk markers for the development of valvular aortic stenosis (as). lipoprotein(a) (lp(a)) and chlamydia pneumoniae igg antibody titres in plasma and in circulating immune complexes as well as leptin and tissue plasminogen activator (t-pa) in plasma were studied. | 2003 | 12573277 |
| comparison of a new quantitative ompa-based real-time pcr taqman assay for detection of chlamydia pneumoniae dna in respiratory specimens with four conventional pcr assays. | chlamydia pneumoniae, an important respiratory pathogen, is difficult to culture, and detection rates by conventional pcrs vary considerably. a new quantitative ompa-based real-time pcr assay based on taqman technology for detection of c. pneumoniae in respiratory samples is described, and its performance in terms of sensitivity and reproducibility is compared with those of four published conventional pcrs (one single-step pcr targeting a cloned psti fragment; two nested pcrs, one targeting the ... | 2003 | 12574252 |
| seroprevalence of antibodies to chlamydia pneumoniae in women with preeclampsia. | preeclampsia shares many risk factors and pathophysiologic features with coronary heart disease. we studied whether, like atherosclerosis, preeclampsia is related to seroprevalence of immunoglobulin (ig) g antibodies to chlamydia pneumoniae. | 2003 | 12576242 |
| persistence of chlamydia pneumoniae in degenerative aortic valve stenosis indicated by heat shock protein 60 homologues. | based on the concept of chronic persistent infections with chlamydia pneumoniae among variable stressors for aortic valve degeneration, the study aim was to assess the presence of chlamydial heat shock protein (chsp) 60 and its human homologue (hhsp60) in diseased valvular tissue. | 2003 | 12578339 |
| coinfection of laboratory rats with mycoplasma pulmonis and chlamydia pneumoniae. | routine examinations of conventional outbred wistar rats in our laboratory showed increased serum levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and urea. electron microscopy and specific reactions showed c. pneumoniae and m. pulmonis in lung, liver, spleen, heart, and kidney sections. we could not exclude the fact that other infectious microorganisms detected through routine health surveillance affected the wistar rat colony; however, we have not identifie ... | 2003 | 12580575 |
| rapid and standardized detection of chlamydia pneumoniae using lightcycler real-time fluorescence pcr. | in order to meet the need of many microbiological laboratories for a standardized system for detecting chlamydia pneumoniae in respiratory specimens, a hybridization probe-based lightcycler (roche diagnostics, germany) pcr assay was developed. the assay's analytical sensitivity and specificity were evaluated according to the recommendations of the centers for disease control and prevention (usa) and laboratory centre for disease control (canada). seventy-four bacterial species other than chlamyd ... | 2003 | 12582746 |
| chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells. | we have investigated the effects of chlamydia pneumoniae on human brain endothelial cells (hbmecs) and human monocytes as a mechanism for breaching the blood-brain barrier (bbb) in alzheimer's disease (ad). hbmecs and peripheral blood monocytes may be key components in controlling the entry of c. pneumoniae into the human brain. our results indicate that c. pneumoniae infects blood vessels and monocytes in ad brain tissues compared with normal brain tissue. c. pneumoniae infection stimulates tra ... | 2003 | 12584732 |
| extraction of chlamydia pneumoniae dna from vascular tissue for use in pcr: an evaluation of four procedures. | the objective of this study was to compare four procedures for chlamydia pneumoniae dna extraction from vascular tissue. the nuclisens kit, the qiaamp tissue dna minikit, buffer-saturated phenol and the geneclean ii kit were evaluated, based on the yield of recovered dna, using pcr to detect c. pneumoniae in vascular tissue. the qiaamp tissue procedure had the highest detection level (0.004 inclusion-forming units/sample). all methods, except nuclisens (70 min), had a short handling time (30-40 ... | 2003 | 12588334 |
| chlamydia pneumoniae and multiple infections in the aorta contribute to atherosclerosis. | our previous study on herpesvirus infection including herpes simplex virus type 1 (hsv-1), epstein-barr virus (ebv), cytomegalovirus (cmv) and atherosclerosis revealed that the prevalence of herpesvirus is higher in atherosclerotic aorta than in non-atherosclerotic aorta. infections with two or three forms of the virus have been found only in atherosclerotic aorta. in our current study, we examined both chlamydia pneumoniae and chlamydia trachomatis in herpesvirus-infected aortic tissues, by mea ... | 2002 | 12588444 |
| [the role of chlamydia pneumoniae infection in the pathology of respiratory organs]. | 2002 | 12593168 | |
| chlamydia antibody response in healthy volunteers immunized with nonchlamydial antigens: a randomized, double-blind, placebo-controlled study. | serological analysis is often used for the diagnosis of chlamydial infections. however, an increase in chlamydia antibodies has been reported in patients with parvovirus and mycoplasma infections. whether this antibody response is the result of dual infection or nonchlamydial antigen stimulation is unknown. in a randomized study, 48 healthy volunteers either were immunized against yellow fever, polio, diphtheria, and tetanus (the group receiving intervention with nonchlamydial antigen) or receiv ... | 2003 | 12594639 |
| immunofluorescence in situ and the serologic indices of chlamydia pneumoniae infection in patients with an abdominal aortic aneurysm. | the aim of the study was to evaluate the frequency of chlamydia pneumoniae infection in patients with abdominal aortic aneurysm (aaa) using selected methods. the histological specimens of aneurysm wall were evaluated, the method of immunofluorescence was used to reveal the antigen in the wall of aaa and the titers of specific antibodies of igg, igm and iga classes in blood plasma were marked. atherosclerotic changes in the aneurysm wall were found in all patients. in 20(87%) patients the c. pneu ... | 2002 | 12597340 |
| combined role of the lewis antigenic system, chlamydia pneumoniae, and c-reactive protein in unstable angina. | the goal of this study was to assess the prognostic role of the lewis antigenic system, chlamydia pneumoniae (cp) seropositivity (cp+), and c-reactive protein (crp) levels in unstable angina (ua). | 2003 | 12598063 |
| chlamydia pneumoniae induces tissue factor expression in mouse macrophages via activation of egr-1 and the mek-erk1/2 pathway. | recent studies have suggested that infection with chlamydia pneumoniae (c pneumoniae) may contribute to the instability of atherosclerotic plaques and thrombosis and is associated with acute coronary events. tissue factor (tf), a potent prothrombotic molecule, is expressed by macrophages and other cell types within atherosclerotic lesions and plays an essential role in thrombus formation after plaque rupture. therefore the effects of c pneumoniae on induction of tf expression in macrophages were ... | 2003 | 12600889 |
| impact of chlamydia pneumoniae infection on survival rate after heart transplantation. | as chlamydia pneumoniae (cp), a common cause of respiratory infection, is of vasotropic character, chronic infection may be associated with the development of coronary disease, although there have been few reports on the impact of cp infection on the post-orthotopic heart transplantation (oht) survival rate. | 2003 | 12601289 |
| c-reactive protein, helicobacter pylori, chlamydia pneumoniae, cytomegalovirus and risk for myocardial infarction. | c-reactive protein (crp), chlamydia pneumonia, helicobacter pylori, and cytomegalovirus (cmv) have each been associated with atherosclerosis. we assessed how infection and crp related to risk for subsequent myocardial infarction (mi). | 2003 | 12604160 |
| in vitro activities of rifamycin derivatives abi-1648 (rifalazil, krm-1648), abi-1657, and abi-1131 against chlamydia trachomatis and recent clinical isolates of chlamydia pneumoniae. | abi-1648 (rifalazil) is a semisynthetic rifamycin with potent bactericidal activity against intracellular respiratory bacteria, including mycobacterium tuberculosis, and a long half-life (approximately 60 h) and thus can be administered once weekly. we therefore tested the in vitro activities of abi-1648, its derivatives abi-1657 and abi-1131, azithromycin, and levofloxacin against 10 strains of chlamydia trachomatis and 10 recent clinical isolates of chlamydia pneumoniae. the mics at which 90% ... | 2003 | 12604555 |
| chlamydia pneumoniae and multiple sclerosis: the latest etiologic candidate. | 2003 | 12606874 | |
| infection with chlamydia pneumoniae and risk of multiple sclerosis. | chlamydia pneumoniae (cpn) has been proposed as a possible etiologic agent for multiple sclerosis (ms), but results of previous studies are conflicting. | 2003 | 12606878 |
| measurement of igg antibodies to chlamydia trachomatis by commercial enzyme immunoassays and immunofluorescence in sera from pregnant women and patients with infertility, pelvic inflammatory disease, ectopic pregnancy, and laboratory diagnosed chlamydia psittaci/chlamydia pneumoniae infection. | screening for chlamydia trachomatis specific antibodies is valuable in diagnosing asymptomatic pelvic inflammatory disease (pid) and tubal damage following repeated episodes of pid. the assays in current use are unsuitable for screening large numbers of samples so there is a need to develop more suitable assays. | 2003 | 12610104 |
| infections preceding early arthritis in southern sweden: a prospective population-based study. | to detect evidence of infections preceding early arthritis in southern sweden and to compare the clinical outcome of remission during a 6-month followup for patients with and without signs of prior infection. | 2003 | 12610801 |
| [current views on the pathogenesis of atherosclerosis from the position of infectious pathology]. | the role of immune inflammation at atherogenesis is studied in the paper. two etiological factors of atherosclerosis pathogeny are under examination: the role of modified low density lipoproteins (mldl) and essential parasites (chlamydia pneumoniae and cytomegaloviruses). generality of immune response during persistent infection into a blood vessel wall and deposit or formation of mldl are discussed. the point of view is substantiated that the development of atherosclerotic damages of blood vess ... | 2002 | 12611168 |
| development of a multiplex real-time quantitative pcr assay to detect chlamydia pneumoniae, legionella pneumophila and mycoplasma pneumoniae in respiratory tract secretions. | atypical pathogens such as chlamydia pneumoniae, legionella pneumophila and mycoplasma pneumoniae are an important cause of community-acquired pneumonia. the available detection methods (culture and serology) either lack sensitivity or give only a retrospective diagnosis. in order to improve their detection and quantification in respiratory samples, a real-time multiplex pcr, performed in two separate reactions, was developed for these three pathogens. the comparison of multiplex real-time and c ... | 2003 | 12614979 |
| chlamydia pneumoniae induces neointima formation in coronary arteries of normal pigs. | we evaluated the role of intracoronary, intrapulmonary and macrophage-mediated delivery of c. pneumoniae (cp) on coronary lesion formation. | 2003 | 12618245 |
| chlamydial lps antibodies, intima-media thickness and ischemic events in patients with established atherosclerosis. | chlamydia pneumoniae has been associated with cardiovascular disease. however, studies on the presence of chlamydial antibodies and intima-media thickness (imt) or future ischemic events are inconclusive. we examined the relation between circulating antibodies to chlamydial lipopolysaccharide (clps ab), imt and the occurrence of ischemic events during follow-up in patients with manifest atherosclerotic disease. | 2003 | 12618269 |
| limited association of chlamydia pneumoniae detection with coronary atherosclerosis. | the association of chlamydia pneumoniae (c. pneumoniae) detection with atherosclerosis has been controversial because of recent conflicting results. in order to assess how and to what extent c. pneumoniae detection contributes to atherosclerosis, the association between immunohistochemical detection of c. pneumoniae antigen, intimal lesions, and the intimal thickening ratio was examined in 1674 left anterior descending coronary arterial segments from 100 autopsied japanese patients being free fr ... | 2003 | 12618271 |
| [an atypical infectious paraplegia]. | spinal cord abscess is an unusual cause of progressive paraplegia. we report the case of a 75-year-old man who presented chlamydia pneumoniae bronchopulmonary infection with secondary spinal cord localization. little clinical improvement was observed with antibiotic therapy, but the neuroradiological course was favorable. | 2003 | 12618658 |
| etiology of acute lower respiratory tract infection. | to identify pathogens responsible for acute severe lower respiratory tract infection (alrti) in under five children by non-invasive methods. | 2003 | 12619950 |
| differential expression of genes encoding membrane proteins between acute and continuous chlamydia pneumoniae infections. | chlamydia pneumoniae is associated with several chronic human diseases, including chronic obstructive pulmonary disease and atherosclerotic cardiovascular disease. during chronic disease, organisms are believed to exist in a persistent phase that is not well understood at the genetic level. long-term in vitro continuous infections are spontaneously persistent and are less susceptible than in vitro acute infections to treatment with antibiotics, and are therefore particularly relevant as an in vi ... | 2003 | 12620380 |
| infectious agents and multiple sclerosis--are chlamydia pneumoniae and human herpes virus 6 involved? | a good deal of evidence suggests an infectious component in the development of multiple sclerosis (ms) and, to date, some 20 bacteria and viruses have been associated with the disease. recent independent sets of studies have implicated the respiratory bacterium chlamydia pneumoniae and human herpes virus 6 (hhv-6) in the pathogenesis of ms. however, as is the case for essentially all earlier microbial associations, experimental evidence linking either this bacterium or this virus to ms is equivo ... | 2003 | 12620637 |
| molecular identification and antibody testing of chlamydophila pneumoniae in a subgroup of patients with hiv-associated dementia complex. preliminary results. | chlamydophila pneumoniae dna was investigated by polymerase chain reaction (pcr), in cerebrospinal fluid (csf) specimens from patients suffering from hiv-1-associated dementia complex (hadc). four (17.3%) cases of c. pneumoniae infection were identified among 23 hadc individuals with dna amplification of major outer membrane protein (momp) gene and 16s rrna gene sequences. sequence analysis revealed significant homologies with c. pneumoniae compared to chlamydia trachomatis and chlamydia psittac ... | 2003 | 12620657 |
| chlamydia pneumoniae infection in adult patients with persistent cough. | chlamydia pneumoniae is a frequent causative agent of acute respiratory disease. to assess whether c. pneumoniae plays a role in persistent cough, the prevalence of c. pneumoniae infection in adult patients with persistent cough was investigated. nasopharyngeal swabs and serology samples from 366 adult patients with a persistent cough lasting in excess of 2 weeks and 106 control subjects were analysed for bacterial isolation and by pcr. c. pneumoniae was isolated from two patients and from none ... | 2003 | 12621093 |
| [chlamydia pneumoniae antibodies and other atherosclerosis risk factors in haemodialysed patients. preliminary report]. | nowadays, it is considered that viral or bacterial infections can influence atherosclerosis development rate. one of them is infection by chlamydia pneumoniae. the aim of the study was to assess the occurrence of anti-chlamydia pneumoniae antibodies (achpa) and their relationship with biochemical and clinical atherosclerosis risk factors in haemodialysed patients. there were 38 patients (24m, 14f) at the mean age 63.3 +/- 14.5 years, haemodialysed for 30.9 +/- 26.1 months. previous ch. pneumonia ... | 2002 | 12621753 |
| chlamydia infection in children with acquired subglottic stenosis. | the purpose of the study was to find out the frequency of occurrence and the role of chlamydia infection in the pathogenesis of acquired subglottic stenosis in children. forty-nine patients of the age from 1 year 10 months to 15 years with acquired cicatricial laryngotracheal stenosis were examined. the immunofluorescent method was used to detect serum antibodies to the antigens of chlamydia trachomatis and chlamydia pneumoniae. dilutions of 1:32 for c. trachomatis and 1:64 for c. pneumoniae wer ... | 2003 | 12623155 |
| chlamydia pneumoniae and aortic aneurysms. | 2002 | 12626197 | |
| chlamydia pneumoniae in patients undergoing surgery for thoracic aortic disease. | to investigate if chlamydia pneumoniae is present in the wall of the thoracic aorta in patients operated on for aneurysm or aortic dissection. | 2002 | 12626198 |
| viral and bacterial dna in carotid atherosclerotic lesions. | atherosclerosis is a major health problem in industrialised countries. several studies have suggested an association exists between certain microorganisms and the development of atherosclerosis. the aim of the study presented here was to assess the presence of viral or bacterial dna in carotid atherosclerotic lesions. nucleic acids were extracted from 18 carotid atherosclerotic lesions that had been collected surgically. polymerase chain reaction was used to screen for specific genomic dna from ... | 2003 | 12627283 |
| anti-chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults. | a multicenter prospective study was performed on 160 asthmatic adults suffering from acute episodes of bronchitis and 88 non-asthmatic controls, to investigate potential associations among chlamydia pneumoniae infection and/or anti-c. pneumoniae heat shock protein 10 antibodies, and asthma. we used micro-immunofluorescence to detect serum anti-c. pneumoniae igg, iga and igm antibodies and enzyme-linked immunosorbent assay to detect serum anti-chsp10 peptide igg antibodies. the serological preval ... | 2003 | 12628545 |
| antibiotic treatment of atherosclerotic cardiovascular disease. | 2003 | 12628937 | |
| antibiotic therapy after acute myocardial infarction: a prospective randomized study. | infection with chlamydia pneumoniae is suspected to contribute to the pathogenesis of human atherosclerosis. we investigated whether treatment with the macrolide antibiotic roxithromycin would reduce mortality or morbidity in patients with an acute myocardial infarction. | 2003 | 12628944 |
| chlamydia pneumoniae and coronary artery disease: the antibiotic trials. | parallel with the mounting evidence that atherosclerosis has a major inflammatory component, provoking agents that may initiate and drive this process have been sought. infectious agents such as chlamydia pneumoniae have been alleged to be activators of inflammation that may contribute to atherosclerosis and thus coronary artery disease (cad) and its associated complications. a logical pneumoniae extension of this theory whether treating c pneumoniae infection with antibiotics and/or modulating ... | 2003 | 12630585 |
| [bacterial flora from bronchoalveolar lavage and occurrence of class igg and iga antibodies to chlamydia pneumoniae in patients with chronic obstructive pulmonary disease (copd)]. | bronchoalveolar lavage taken from 46 patients (ranging in age from 21 to 71 years, mean 50.6 +/- 13.9) was examined for aerobic and anaerobic bacterial flora. sera taken from 39 of patients as well as sera taken from 25 healthy blood donors of similar age (p = 0.99) were examined to determine igg and iga antibodies to c. pneumoniae. bacterial flora was routinely cultured and determined using atb computer system (biomérieux,). igg and iga antibodies were tested by the enzyme immunoassays (labsyst ... | 2002 | 12632661 |
| effect of short-term antibiotic treatment on chlamydia pneumoniae and peripheral endothelial function. | 2003 | 12633811 | |
| chlamydia pneumoniae survival in macrophages is regulated by free ca2+ dependent reactive nitrogen and oxygen species. | despite an efficient macrophage immune capability, chlamydia pneumoniae infects host cells and causes chronic diseases. to gain better insights into c. pneumoniae survival mechanisms in macrophages, its growth in regular raw-264.7 cells (nitric oxide sufficient no (+)) and raw-264.7 cells (nitric oxide insufficient no (-)) were studied. | 2003 | 12634074 |
| anti chlamydia antibodies in patients with thoracic and abdominal aortic aneurysms. | chlamydia species are suspected of being involved in the pathogenesis and progression of aortic aneurysms. we investigated serum levels of chlamydia antibodies in patients with thoracic aortic aneurysms (taa) and abdominal aortic aneurysms (aaa) compared to levels in healthy individuals. | 2002 | 12635464 |
| effect of short-term treatment with azithromycin on recurrent ischaemic events in patients with acute coronary syndrome in the azithromycin in acute coronary syndrome (azacs) trial: a randomised controlled trial. | there is serological and epidemiological evidence of an association between chlamydia pneumoniae infection and coronary artery disease. results of previous smaller studies have indicated a reduction of recurrent ischaemic events in patients with acute coronary syndrome when given macrolide antibiotics. we aimed to assess whether short-term treatment with the macrolide antibiotic azithromycin reduces recurrent ischaemic events in patients admitted for unstable angina or myocardial infarction. | 2003 | 12642046 |
| cloning, expression and purification of three chaperonin 60 homologues. | the chaperonin 60 (cpn60) proteins have, in addition to their well-known functions of protein folding and protection, a range of intercellular signalling activities. as part of a study to investigate the biological activity of the cpn60 proteins, particularly from pathogenic organisms, we have cloned and expressed three cpn60 proteins from homo sapiens, helicobacter pylori and chlamydia pneumoniae. the cpn60 proteins were purified to apparent homogeneity using a combination of nickel column affi ... | 2003 | 12651007 |
| chlamydia pneumoniae and atherosclerosis. | chlamydia pneumoniae is a human respiratory pathogen that causes acute respiratory disease. multiple studies have associated c. pneumoniae with cardiovascular disease including seroepidemiologic studies, direct detection of the organism within the lesion, and isolation of the organism from atheromatous tissue. the most critical question to be answered by researchers in the field is whether c. pneumoniae plays a role in atherogenesis. this review summarizes in vitro studies, results in animal mod ... | 2003 | 12652454 |
| in vitro activity of a new antibiotic, nvp-pdf386 (vrc4887), against chlamydia pneumoniae. | the in vitro activity of nvp-pdf386 (vrc4887), a novel new peptide deformylase inhibitor, and those of levofloxacin and clarithromycin were tested against 21 isolates of chlamydia pneumoniae. the mic at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by nvp-pdf386 for all isolates of c. pneumoniae were 0.008 micro g/ml (range, 0.008 to 0.015 micro g/ml) compared to 0.25 and 0.06 micro g/ml for levofloxacin and clarithro ... | 2003 | 12654690 |
| microbiological efficacy of abt-773 (cethromycin) for the treatment of community-acquired pneumonia due to chlamydia pneumoniae. | nasopharyngeal specimens for culture of chlamydia pneumoniae were obtained from patients with community-acquired pneumonia enrolled in a randomized study comparing the novel ketolide antibiotic abt-773 at a dose of 150 mg once a day to 150 mg twice a day, by mouth for 10 days. c. pneumoniae was eradicated from the nasopharynx of 10 of 10 (100%) microbiologically evaluable patients. mics and mbcs for 13 isolates of c. pneumoniae from 12 patients obtained before and after therapy were performed ag ... | 2003 | 12654764 |
| [no detection of chlamydia pneumoniae in normal and atherosclerotic femoral arteries by polymerase chain reaction (pcr)--an autopsy study]. | since saikku's investigations in 1988 a direct relation between atherosclerosis and infection with chlamydia pneumoniae has been suspected. the aim of the present study was to examine histologically normal and atherosclerotic femoral arteries of autopsy cases and to correlate histological findings with the presence of chlamydia pneumoniae which was tested with nested polymerase chain reaction. the study included all of the femoral arteries (of which 16 male, 15 female, aged between 50 and 88 yea ... | 2003 | 12658470 |
| antibodies against chlamydia pneumoniae in stable angina and interleukin-6 levels. | 2003 | 12659992 | |
| meta-analysis of sero-epidemiologic studies of the relation between chlamydia pneumoniae and atherosclerosis: does study design influence results? | the results of sero-epidemiologic studies of the relation between chlamydia pneumoniae and atherogenesis vary considerably. a meta-analysis was performed to calculate the overall odds ratio (or) and to identify potential sources of variability. | 2003 | 12660662 |
| chlamydia pneumoniae infection of alveolar macrophages: a model. | chlamydia (chlamydophila) pneumoniae is a common respiratory pathogen, and it seems likely that alveolar macrophages may have an important role in infection with this bacterium. in the present study, we examined the usefulness of a continuous cell line of murine alveolar macrophages, designated "mh-s," as an in vitro c. pneumoniae infection model. infection of mh-s cells with c. pneumoniae resulted in the development of typical inclusion bodies in the cells, similar to that seen in primary alveo ... | 2003 | 12660925 |
| recruitment of chlamydia pneumoniae-infected macrophages to the carotid artery wall in noninfected, nonatherosclerotic mice. | monocyte recruitment into the subendothelium is a crucial step in atherogenesis. chlamydia pneumoniae resides in circulating monocytes and in the atherosclerotic vascular wall. however, the role of c pneumoniae for monocyte recruitment is unknown. the aim of this study was to examine the impact of c pneumoniae on monocyte adhesion and migration. | 2003 | 12663369 |
| chlamydia pneumoniae, but not bartonella quintana, is associated with coronary heart disease: results of a french case-control study. | serologic cross-reactivity has been demonstrated between bartonella quintana and chlamydia pneumoniae. therefore, the association between antibodies to c. pneumoniae and coronary heart disease (chd) as described in the literature may be due to antibodies cross-reacting with b. quintana. to investigate this hypothesis, we evaluated, in a case-control study, the prevalence of c. pneumoniae and b. quintana antibodies among 296 cases with angiographically significant artery lesions and 170 controls ... | 2003 | 12667243 |
| a cluster of cases of severe acute respiratory syndrome in hong kong. | information on the clinical features of the severe acute respiratory syndrome (sars) will be of value to physicians caring for patients suspected of having this disorder. | 2003 | 12671062 |
| chlamydia pneumoniae affect surfactant trafficking and secretion due to changes of type ii cell cytoskeleton. | understanding the surfactant dysfunction by gram-negative bacteria pulmonary infection, the intracellular fate of chlamydia pneumoniae (cpn), its interaction with uptake, recycling, and secretion of surfactant and with the cytoskeleton of type ii pneumocytes was investigated. bacteria colocalized with surfactant protein (sp)-a-mediated endocytosed lipid and early endosomes (eea1- and rab5-positive) after 3 and 6 h of infection. no specific contact with late endosomes (rab7- and m6pr-positive), l ... | 2003 | 12676805 |
| a family with abdominal aortic aneurysms. | this investigation focused on 7 siblings to 2 brothers with abdominal aortic aneurysm (aaa), with respect to aaa, chlamydia pneumoniae (cp) serology, serum cholesterol, and smoking habits. five male and 4 female siblings were included. all siblings underwent ultrasonography, and surgical specimens from the aorta were prepared for immunohistochemical (ihc) analysis. blood was obtained from all living siblings and serum cholesterol level was analyzed. serologic analysis was done by microimmunofluo ... | 2003 | 12678192 |
| in vitro antibiotic activity against chlamydia pneumoniae clinical isolates. | 2003 | 12678424 | |
| absence of association between infectious agents and endothelial function in healthy young men. | although several studies have reported correlations between infections and coronary artery disease, associations with endothelial dysfunction, its precursor, have not been established. this study assessed whether infection with chlamydia pneumoniae (cp), cytomegalovirus (cmv), epstein-barr virus (ebv), or helicobacter pylori (hp) is associated with decreased endothelial function. | 2003 | 12681997 |
| distribution of chlamydia pneumoniae dna in atherosclerotic carotid arteries: significance for sampling procedures. | despite extensive efforts to confirm a direct association between chlamydia pneumoniae and atherosclerosis, different laboratories continue to report a large variability in detection rates. in this study, we analyzed multiple sections from atherosclerotic carotid arteries from 10 endartectomy patients to determine the location of c. pneumoniae dna and the number of sections of the plaque required for analysis to obtain a 95% confidence of detecting the bacterium. a sensitive nested pcr assay det ... | 2003 | 12682129 |
| genome sequence of chlamydophila caviae (chlamydia psittaci gpic): examining the role of niche-specific genes in the evolution of the chlamydiaceae. | the genome of chlamydophila caviae (formerly chlamydia psittaci, gpic isolate) (1 173 390 nt with a plasmid of 7966 nt) was determined, representing the fourth species with a complete genome sequence from the chlamydiaceae family of obligate intracellular bacterial pathogens. of 1009 annotated genes, 798 were conserved in all three other completed chlamydiaceae genomes. the c.caviae genome contains 68 genes that lack orthologs in any other completed chlamydial genomes, including tryptophan and t ... | 2003 | 12682364 |
| chlamydia pneumoniae antibodies and endothelial function as assessed by flow-mediated dilation in patients with chest pain with and without ischemic heart disease. | 2003 | 12686343 | |
| detection of chlamydia pneumoniae in peripheral blood mononuclear cells: correlation with inflammation and atherosclerosis in haemodialysis patients. | chlamydia pneumoniae has been implicated as an inflammatory agent in atherosclerosis. clinical studies in this field have yielded conflicting results, which may have resulted from a lack of standardization for c.pneumoniae detection. we attempted to accurately estimate c.pneumoniae prevalence and to examine whether c.pneumoniae is associated with atherosclerosis and inflammation in haemodialysis (hd) patients. to do this, we assessed c.pneumoniae presence by a combination of methods and correlat ... | 2003 | 12686665 |
| [the role of chlamydia pneumoniae infection in the development of atherosclerosis in humans]. | 2002 | 12687938 | |
| [evaluation of community-acquired pneumonia guidelines of japanese respiratory society: differentiation of atypical pneumonia and bacterial pneumonia]. | to evaluate the usefulness of differentiation of atypical pneumonia and bacterial pneumonia in the community-acquired pneumonia guidelines of the japanese respiratory society, we investigated 124 cases of three atypical pneumonias (mycoplasma pneumonia, 62 cases; chlamydia pneumoniae pneumonia, 46 cases; chlamydia psittaci pneumonia, 13 cases) and 403 cases of bacterial pneumonia at our hospital over seven years. overall, the sensitivity and specificity of the criteria in the guideline were 70.4 ... | 2002 | 12692942 |