Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| a putative nuclear growth factor-like globular nematode specific protein. | expressed sequence tags (ests) are an effective approach for discovery of novel genes. in the current study, approximately 250 ests of the cattle parasitic nematode setaria digitata were examined and a cdna clone identified whose coding sequence could not be functionally annotated by searching over publicly available genome, protein, est and sts databases. here, we report the extensive characterization of this orf (up) and its homologues using a bioinformatic approach. uncharacterized protein (s ... | 2009 | 19759810 |
| an allele specific pcr assay for screening for drug resistance among wuchereria bancrofti populations in india. | albendazole, a commonly used anthelminthic drug that targets the polymerization of alpha- and beta-tubulin dimer is currently co-administered with the antifilarial drug, diethylcarbamazine citrate (dec) in the ongoing global programme for elimination of lymphatic filariasis (gpelf). the experience in veterinary field has shown that there can be a rapid development of resistance to this drug, which therefore, needs to be monitored regularly in gpelf. hence, we investigated the nucleotide polymorp ... | 2009 | 19797818 |
| a randomized trial of doxycycline for mansonella perstans infection. | mansonella perstans infection is common in areas of africa where wuchereria bancrofti, a causative agent of lymphatic filariasis, is endemic. m. perstans is refractory to standard antifilarial therapies. the recent discovery of bacterial endosymbionts (e.g., wolbachia) in most filarial species, including m. perstans, provides new therapeutic options for reducing microfilaremia. | 2009 | 19812401 |
| mansonella perstans--the importance of an endosymbiont. | 2009 | 19812409 | |
| macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. | in a placebo controlled trial, the effects of 21- and 10-day doxycycline treatments (200 mg/day) followed by single dose diethylcarbamazine (administered 4 months post treatment) on depletion of wolbachia endobacteria from wuchereria bancrofti, filaricidal activity, and amerlioration of scrotal lymph vessel dilation were studied in 57 men from orissa, india. the 21-day doxycycline course reduced wolbachia in w. bancrofti by 94% before diethylcarbamazine administration. after 12 months, all patie ... | 2009 | 19815891 |
| mosquito infection responses to developing filarial worms. | human lymphatic filariasis is a mosquito-vectored disease caused by the nematode parasites wuchereria bancrofti, brugia malayi and brugia timori. these are relatively large roundworms that can cause considerable damage in compatible mosquito vectors. in order to assess how mosquitoes respond to infection in compatible mosquito-filarial worm associations, microarray analysis was used to evaluate transcriptome changes in aedes aegypti at various times during b. malayi development. changes in trans ... | 2009 | 19823571 |
| filariasis and lymphoedema. | among the causes of lymphoedema (le), secondary le due to filariasis is the most prevalent. it affects only a minority of the 120 million people infected with the causative organisms of lymphatic filariasis (lf), wuchereria bancrofti and brugia malayi/timori, but is clustered in families, indicating a genetic basis for development of this pathology. the majority of infected individuals develop filarial-specific immunosuppression that starts even before birth in cases where mothers are infected a ... | 2009 | 19825106 |
| imported bancroftian filariasis: diethylcarbamazine response and benzimidazole susceptibility of wuchereria bancrofti in dynamic cross-border migrant population targeted by the national program to eliminate lymphatic filariasis in south thailand. | the implementation on the thailand-myanmar border of annual mass drug administration (mda) of a single 6 mg/kg dose of diethylcarbamazine (dec) plus 400mg albendazole, part of the national program to eliminate lymphatic filariasis (pelf), has been challenging. in particular, chain migration of cross-border myanmar workers at risk for nocturnally periodic wuchereria bancrofti infection can lead to imported bancroftian filariasis (ibf) in thailand. ibf is targeted for multiple-dose mda with 300 mg ... | 2010 | 19835831 |
| dna-based diagnosis of lymphatic filariasis. | lymphatic filariasis (lf) is still a major public health problem. the disease is ranked by the world health organization (who) as the second leading cause of permanent and long-term disability, and has been targeted for elimination by 2020. effective diagnosis lf is required for treatment of infected individuals, for epidemiological assessment and for monitoring of the control program. conventional diagnosis of lf depends on detection of microfilariae (mf) in blood specimens, which has low sensi ... | 2009 | 19842372 |
| ten years of managing the clinical manifestations and disabilities of lymphatic filariasis. | the aim of the global programme to eliminate lymphatic filariasis is to eradicate one of the world's leading causes of permanent and long-term disability, at least as a public-health problem. the achievement of this goal is based on the interruption of the transmission of the causative parasites (so preventing new cases) and, as a 'second pillar', the prevention of disability in those who are infected. the disability is associated with the main clinical manifestations of human infection with wuc ... | 2009 | 19843392 |
| lymphatic filariasis: patients and the global elimination programme. | the defining images of lymphatic filariasis are the horrendous disfigurements of lymphoedema, elephantiasis and hydrocele. these clinical presentations, although obviously important and life changing, are not, however, the only outcomes of this wide-spread filarial infection. the other effects of the disease range from severe, acute but short-term bouts of sickness to psychological impairment, poverty and family hardship. it is important to support cases of the disease through all means availabl ... | 2009 | 19843397 |
| the sharp end - experiences from the tanzanian programme for the elimination of lymphatic filariasis: notes from the end of the road. | the tanzania lymphatic filariasis programme, which was launched in 2000, is, in terms of geographical coverage, among the largest disease-control programmes in tanzania's history, currently reaching 9.4 million people in 34 districts. the issues associated with this programme's implementation are reviewed here, in the context of the various players/stakeholders involved. this article provides an insight of how the programme began and discusses key areas in the programme's design. mainly, however ... | 2009 | 19843398 |
| transplacental transfer of filarial antigens from wuchereria bancrofti-infected mothers to their offspring. | maternal infection has been considered to be a risk factor for filarial infection in offspring. in order to examine the influence of maternal infection in neonates, we have determined the prevalence of circulating filarial antigen (cfa) and anti-filarial antibodies in 119 maternal and corresponding cord blood samples collected from an area endemic for bancroftian filariasis. | 2010 | 19849889 |
| integrated mapping of neglected tropical diseases: epidemiological findings and control implications for northern bahr-el-ghazal state, southern sudan. | there are few detailed data on the geographic distribution of most neglected tropical diseases (ntds) in post-conflict southern sudan. to guide intervention by the recently established national programme for integrated ntd control, we conducted an integrated prevalence survey for schistosomiasis, soil-transmitted helminth (sth) infection, lymphatic filariasis (lf), and loiasis in northern bahr-el-ghazal state. our aim was to establish which communities require mass drug administration (mda) with ... | 2009 | 19859537 |
| isolation of an antigen fraction from setaria cervi adults having potential for immunodiagnosis of human filariasis. | crude antigenic preparations from heterologous filarial parasites gave false positive results because of complex nature of these antigens and their cross-reactivity with other helminth parasites. in the present study, efforts have been made to isolate and characterize the antigens from setaria cervi important for diagnostic purposes. the fractionation of s. cervi somatic antigenic preparation on sephacryl s-200 resulted in separation of three major antigenic peak fractions. crossed immunoelectro ... | 2009 | 19860586 |
| interruption of annual single dose dec regimen administration: impact on wuchereria bancrofti microfilaraemia, vector infection and infectivity rates. | the effect of single dose diethylcarbamazine regimen (6 mg/kg body wt.) in comparison to standard dec regimen i.e; 72 mg/kg body wt (administered in 12 consecutive days) in clearing wuchereria bancrofti microfilariae from low density micro filariae carriers (1- 8 mf per 20 microl) and its impact on vector infection rate were studied in an urban region endemic for bancroftian filariasis. the efficacy of dec regimens were determined by assessing the rate of successful treatment, percentage cure ra ... | 2009 | 19886172 |
| status of lymphatic filariasis in lucknow district, uttar pradesh. | lucknow district was endemic for lymphatic filariasis (lf). during march 2008, lf survey was carried out in 14 randomly selected villages (six primary health centres) and 4 mohallas of lucknow city. out of 3,654 night blood smears (nbs) collected and examined, 209 were found positive for wuchereria bancrofti (micrifilaria rate: 5.7%). microfilaria (mf) carriers were detected from all surveyed villages and mohallas. the age of these positive persons ranged from 6-70 years. in all areas, prevalenc ... | 2009 | 19886174 |
| review on global co-transmission of human plasmodium species and wuchereria bancrofti by anopheles mosquitoes. | malaria and lymphatic filariasis are two of the most common mosquito-borne parasitic diseases worldwide which can occur as concomitant human infections while also sharing common mosquito vectors. this review presents the most recent available information on the co-transmission of human plasmodium species and wuchereria bancrofti by anopheles mosquitoes. important biological and epidemiological aspects are also described including the lifecycle of each parasite species and their specificities, th ... | 2010 | 19941975 |
| association between mannose-binding lectin polymorphisms and wuchereria bancrofti infection in two communities in north-eastern tanzania. | the association between selected mannose-binding lectin (mbl) genotype polymorphisms and wuchereria bancrofti infection status was assessed among individuals whose infection status had been monitored for three decades. blood samples were collected in 2006 and examined for polymorphisms in the mbl-2 gene and for w. bancrofti-specific circulating filarial antigen (cfa) status. logistic regression analysis showed a significant association between mbl genotype and cfa status, with low-expression mbl ... | 2010 | 20065005 |
| doxycycline for mansonella perstans infection. | 2010 | 20089982 | |
| role of fine needle aspiration cytology in diagnosis of filarial infestation. | filariasis is a tropical disease transmitted by the culex mosquitoes. the diagnosis of it is conventionally made by demonstrating microfilariae in the peripheral blood smear. however; microfilariae and adult filarial worm have been incidentally detected in fine needle aspirates of various lesions in clinically unsuspected cases. the cases of filariasis diagnosed by fine needle aspiration cytology (fnac) were retrieved from the archives of the cytopathology laboratory between the periods of janua ... | 2011 | 20091903 |
| wuchereria bancrofti: diminished platelet activation in filarial patients. | blood platelets are the innate immune elements that have not been investigated in human filarial infections. platelet activation status in the endemic normals (en), microfilaria positive individuals (mf) and patients with chronic pathology (cp) was evaluated in whole blood, under unstimulated as well as antigen exposed (bma, e. coli) conditions for pac-1 expression by flow cytometry. a diminished pac-1 expression was observed in mf compared to cp and en spontaneously as well as upon antigen expo ... | 2010 | 20093116 |
| lymphatic filarial species differentiation using evolutionarily modified tandem repeats: generation of new genetic markers. | polymerase chain reaction based methods are promising tools for the monitoring and evaluation of the global program for the elimination of lymphatic filariasis. the currently available pcr methods do not differentiate the dna of wuchereria bancrofti or brugia malayi by a single pcr and hence are cumbersome. therefore, we designed a single step pcr strategy for differentiating bancroftian infection from brugian infection based on a newly identified gene from the w. bancrofti genome, abundant larv ... | 2010 | 20132908 |
| the long battle against a horrific disease. | 2010 | 20133549 | |
| molecular characterization of a truncated antigen (wb14) of sxp-1 of wuchereria bancrofti from four endemic regions in india. | wb14 of wuchereria bancrofti, an orthologue of brugia malayi sxp-1 and w. bancrofti sxp-1, was amplified from genomic dna of w. bancrofti microfilaria collected from four distant geographical locations in india viz., vellore, bhubaneshwar, pondicherry and sevagram. the gene was sub-cloned in a prokaryotic vector prset and expressed in escherichia coli as a truncated protein (approximately 23kda). the nucleotide sequence of the gene is 98% similar to that of wbsxp-1 and is found to be intron-less ... | 2010 | 20138869 |
| detection of wuchereria bancrofti l3 larvae in mosquitoes: a reverse transcriptase pcr assay evaluating infection and infectivity. | detection of filarial dna in mosquitoes by pcr cannot differentiate infective mosquitoes from infected mosquitoes. in order to evaluate transmission risk an assay is needed that can specifically detect infective l3 stage parasites. we now report the development of an assay that specifically detects the infective stage of wuchereria bancrofti in mosquitoes. the assay detects an l3-activated mrna transcript by reverse-transcriptase pcr (rt-pcr). | 2010 | 20169115 |
| an integrative treatment for lower limb lymphedema (elephantiasis). | 2010 | 20180687 | |
| filarial selenium glutathione peroxidase: a probable immunodiagnostic marker for lymphatic filariasis. | lymphatic filariasis (lf) caused by wuchereria bancrofti is widely prevalent in tropical and subtropical countries. night blood film examination is most commonly used for diagnosis of filariasis but is cumbersome and labour intensive. in order to develop an indirect elisa-based immunodiagnostic test, the importance of antifilarial igg subclasses was evaluated in bancroftian filariasis patients. blood samples from healthy individuals and different categories of lf patients were used to estimate t ... | 2010 | 20227740 |
| molecular evidence for a functional ecdysone signaling system in brugia malayi. | filarial nematodes, including brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. an understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. pharmacological evidence suggests that ecdysteroids play a role in parasitic nematode molting and fertility although their specific function remains unknown. in insects, ecdysone triggers molting through th ... | 2010 | 20231890 |
| ultrastructural analysis of wuchereria bancrofti (nematoda: filarioidea) body wall. | bancroftian filariasis constitutes the principal mosquito-borne nematode infection of humans and the surface of adult of wuchereria bancrofti seems to be especially important in the intricate interplay between host and parasite. the study of the parasite's surface structure might help to understand the localization and function of various organelles. w. bancrofti adult worms were recovered from untreated patients during hydrocele repair surgery and studied by transmission electron microscopy. th ... | 2010 | 20236829 |
| studies on filariasis; potential mosquito vectors of wuchereria bancrofti. | 1946 | 20244141 | |
| [not available]. | 1947 | 20270414 | |
| further studies on the treatment of filariasis due to wuchereria bancrofti with lithium antimony thiomalate. | 1946 | 20274590 | |
| infectivity of pacific island wuchereria bancrofti to mosquitoes of the united states. | 1947 | 20292228 | |
| development and characterization of monoclonal antibodies against wbsxp-1 for the detection of circulating filarial antigens. | the importance of developing effective assays to diagnose, monitor and evaluate human lymphatic filariasis has been emphasized by the world health organization. presently, few immunodiagnostics are available for filarial monitoring programmes. the wuchereria bancrofti (wb) sxp-1 parasite protein, with 84% homology to brugia malayi (bm) sxp-1, was found to be highly immunogenic. wbsxp-1 is one among the diagnostic candidate molecules that were used for developing a rapid-antibody-flow-through dia ... | 2011 | 20338077 |
| at homeostasis filarial infections have expanded adaptive t regulatory but not classical th2 cells. | despite the well-documented immune suppression associated with human helminth infections, studies characterizing the immune response at the single-cell level are scanty. we used multiparameter flow cytometry to characterize the type of effector (th1, th2, and th17) and regulatory (natural t regulatory cells [ntregs] and adaptive treg cells [atreg/type 1 regulatory cells (tr1s)]) cd4(+) and cd8(+) t cells in filaria-infected (fil(+)) and -uninfected (fil(-)) individuals at homeostasis (in the abs ... | 2010 | 20357251 |
| mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of wolbachia from filarial nematodes. | the filarial nematodes brugia malayi, wuchereria bancrofti and onchocerca volvulus cause elephantiasis or dermatitis and blindness resulting in severe morbidity. annually, 1.3 billion people are at risk of infection. targeting the essential wolbachia endobacteria of filarial nematodes with doxycycline has proven to be an effective therapy resulting in a block in embryogenesis, worm development and macrofilaricidal effects. however, doxycycline is contraindicated for a large portion of the at ris ... | 2010 | 20362581 |
| evidence for wolbachia symbiosis in microfilariae of wuchereria bancrofti from west bengal, india. | wolbachia are symbiotic endobacteria that infect the majority of filarial nematodes, including wuchereria bancrofti, brugia malayi and onchocerca volvulus. recent studies have suggested that wolbachia are necessary for the reproduction and survival of filarial nematodes and have highlighted the use of antibiotic therapy such as tetracycline/doxycycline as a novel method of treatment for infections caused by these organisms. before such therapy is conceived and implemented on a large scale, it is ... | 2010 | 20413911 |
| feasibility and effectiveness of basic lymphedema management in leogane, haiti, an area endemic for bancroftian filariasis. | approximately 14 million persons living in areas endemic for lymphatic filariasis have lymphedema of the leg. clinical studies indicate that repeated episodes of bacterial acute dermatolymphangioadenitis (adla) lead to progression of lymphedema and that basic lymphedema management, which emphasizes hygiene, skin care, exercise, and leg elevation, can reduce adla frequency. however, few studies have prospectively evaluated the effectiveness of basic lymphedema management or assessed the role of c ... | 2010 | 20422031 |
| a multicenter evaluation of a new antibody test kit for lymphatic filariasis employing recombinant brugia malayi antigen bm-14. | antibody tests are useful for mapping the distribution of lymphatic filariasis (lf) in countries and regions and for monitoring progress in elimination programs based on mass drug administration (mda). prior antibody tests have suffered from poor sensitivity and/or specificity or from a lack of standardization. we conducted a multicenter evaluation of a new commercial elisa that detects igg4 antibodies to the recombinant filarial antigen bm14. four laboratories tested a shared panel of coded ser ... | 2010 | 20430004 |
| production and immunological characterization of a recombinant subunit of a loa loa polyprotein antigen. | diagnosis of loiasis and analysis of the specific immune response are limited by a paucity of parasite material. to circumvent this problem, a loa loa antigen has been expressed in a prokaryote vector (ptrchis). immunization of balb/c mice with this soluble recombinant protein produced a strong antibody response, with antibodies recognizing 2 major bands of 38 and 20 kda in a native crude extract of loa loa adult worms and microfilariae on western blots. the target molecule was located mainly in ... | 2010 | 20441677 |
| microfilariae in lymph node aspirate associated with metastatic gastric carcinoma: a case report. | microfilariae of wuchereria bancrofti inhabit peripheral blood, and nocturnal periodicity is observed in the indian subcontinent. however, microfilariae have been reported in various tissues and organs by needle aspiration cytology in atypical cases. occasionally, they were detected in cases with some diseases including malignancy. | 2010 | 20518418 |
| retroperitoneal filariasis diagnosed by fine needle aspiration: a case report. | filarial worms lodge anywhere, from body fluids to subcutaneous tissue, as various case reports prove. | 2010 | 20518420 |
| molecular-based assay for simultaneous detection of four plasmodium spp. and wuchereria bancrofti infections. | four major malaria-causing plasmodium spp. and lymphatic filariasis-causing wuchereria bancrofti are co-endemic in many tropical and sub-tropical regions. among molecular diagnostic assays, multiplex polymerase chain reaction (pcr)-based assays for the simultaneous detection of dnas from these parasite species are currently available only for p. falciparum and w. bancrofti or p. vivax and w. bancrofti. using a post-pcr oligonucleotide ligation detection reaction-fluorescent microsphere assay (ld ... | 2010 | 20519596 |
| a mechanism for chronic filarial hydrocele with implications for its surgical repair. | chronic hydrocele is the most common manifestation of bancroftian filariasis, an endemic disease in 80 countries. in a prospective study, we evaluated the occurrence of intrascrotal lymphangiectasia, gross appearance/consistency of the testis, and the efficacy of complete excision of hydrocele sac in patients living in a bancroftian filariasis endemic area who underwent hydrocelectomy at the center for teaching, research and tertiary referral for bancroftian filariasis (nepaf). | 2010 | 20532225 |
| bancroftian filariasis among the mbembe people of cross river state, nigeria. | bancroftian filariasis is a major public health and socioeconomic problems in the humid tropical and subtropical regions of the world. a study was undertaken to investigate the status of the disease in some rural communities of cross river state, nigeria, with a view to enriching the epidemiological baseline data of the disease in nigeria. | 2010 | 20539046 |
| association between toll-like receptor 2 (tlr2) polymorphisms and asymptomatic bancroftian filariasis. | lymphatic filariasis is mainly caused by the filarial nematodes wuchereria bancrofti and brugia malayi. wolbachia, intracellular symbiotic bacteria in filarial parasite, is known to induce immune response predominantly through toll-like receptor 2 (tlr2). this study was performed to investigate the association between polymorphisms of the tlr2 gene and susceptibility to asymptomatic bancroftian filariasis. a total of 142 unrelated asymptomatic bancroftian filariasis patients and 151 endemic norm ... | 2010 | 20549240 |
| lymphatic filariasis in children: age dependent prevalence in an area of india endemic for wuchereria bancrofti infection. | lymphatic filariasis has been considered as a disease of adults and most epidemiological surveys have excluded children. the prevalence of infection and clinical manifestations of the disease among children in the age group of 1-15 years was determined in a wuchereria bancrofti endemic area. the 1383 children from the rural villages of a coastal district (khurda), state of orissa, india, were studied. the finger prick blood (50ìl) samples were collected between 20:30 and 23:30 hours for parasito ... | 2010 | 20562812 |
| assessment of family and neighbors of an individual infected with wuchereria bancrofti from a non-endemic area in the city of maceió, brazil. | the family and neighbors of a patient infected with w. bancrofti microfilariae were assessed aiming to evaluate the occurrence of cases of lymphatic filariasis in a non-endemic area in the city of maceió, in the brazilian state of alagoas. the patient had previously lived in an endemic focus; however, he has been living in an area where the parasite has never been detected for the past ten years. female ingurgitated culex quinquefasciatus mosquitoes captured in the houses of the microfilaremic i ... | 2010 | 20563436 |
| size and charge antigens of dirofilaria immitis adult worm for igg-elisa diagnosis of bancroftian filariasis. | we used dirofilaria immitis adult worm antigens to develop an igg-elisa, then used this to evaluate 30 serum samples of patients with proven wuchereria bancrofti infection, 131 samples of patients with other parasitic diseases and 30 serum samples of healthy controls. the d. immitis antigen was prepared using two methods: sephacryl s-200 chromatography and iso-electric focusing with a rotofor cell. this was done to determine the best method for diagnosing w. bancrofti filariasis. before fraction ... | 2010 | 20578510 |
| the bacteria wolbachia in filariae, a biological russian dolls' system: new trends in antifilarial treatments. | filarial nematode species can host wolbachia bacterial endosymbionts. to understand the symbiosis, a higher level of complexity should be considered, taking in account the tripartite association between wolbachia, filariae and mammals. this overview article discusses the biology of wolbachia in filariae, including their distribution and phylogeny, mechanisms of action, inflammatory consequences on mammal host and biological control implications for filariases. potential directions for future res ... | 2010 | 20597434 |
| detection and discrimination of loa loa, mansonella perstans and wuchereria bancrofti by pcr-rflp and nested-pcr of ribosomal dna its1 region. | the ribosomal deoxyribonucleic acid (dna) internal transcribed spacer region (its1) of two filarial nematodes, loa loa and mansonella perstans, was amplified and further sequenced to develop an species-specific polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) protocol for the differentiation of both species from wuchereria bancrofti, three filarial nematodes with blood circulating microfilariae. the its1-pcr product digested with the restriction endonuclease ase i ge ... | 2011 | 20599994 |
| elimination of lymphatic filariasis in southeast asia. | approximately 15 million people with lymphatic filariasis (lf) live in southeast asia. wuchereria bancrofti (transmitted by the mansonia and anopheles vectors), brugia malayi and brugia timori (both transmitted by culex quinquefasciatus) are the filarial species in this region. the endemic countries are: cambodia, lao people's democratic republic, the philippines, indonesia, thailand and timor-leste, which have all agreed to eliminate transmission of the disease by 2020. the public health interv ... | 2010 | 20624533 |
| vector transmission heterogeneity and the population dynamics and control of lymphatic filariasis. | a long-standing gap in lymphatic filariasis epidemiology is quantifying the potential effect that heterogeneous infection processes occurring in the major mosquito vector genera may have on parasite transmission and control. although previous studies have focussed on examining the forms of the density dependent mechanisms regulating larval infection in various mosquito genera, there has been little work done thus far in investigating how such differential processes might interact with density-de ... | 2010 | 20632527 |
| the role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. | objective: (i) to determine the frequencies of urogenital pathologies in men infected with bancroftian filariasis, and (ii) to evaluate the role of ultrasonography (usg) as a diagnostic tool to differentiate between diverse pathologies with different clinical implications. to date, all types of scrotal enlargement resulting from lymphatic filariasis (lf) have been summarized under one term: "filaricele". patients and methods: data were compiled from recruitment phases for field trials in an ende ... | 2010 | 20673752 |
| evidence for the exacerbation of lymphedema of geochemical origin, podoconiosis, by onchocerciasis. | the study was conducted to investigate a variation in the distribution of endemic elephantiasis previously determined to be of geochemical origin in three neighbouring and essentially homogenous villages, bambili, bambui and finge of the bambui health district of nw cameroon. a total of 301 subjects were examined for onchocerciasis and lymphatic filariasis in the area using standard procedures. the onchocercal microfilarial prevalence varied from 6.5% in bambili through 20.4% in bambui to 60.4% ... | 2009 | 20701883 |
| lymphatic filariasis in india: epidemiology and control measures. | lymphatic filariasis caused by wuchereria bancrofti and brugia malayi is an important public health problem in india. both parasites produce essentially similar clinical presentations in man, related mainly to the pathology of the lymphatic system. filariasis is endemic in 17 states and six union territories, with about 553 million people at risk of infection. the government of india has accorded a high priority for elimination of this infection through mass chemotherapy programme (annual, singl ... | 2010 | 20739779 |
| crucial epitopes of wuchereria bancrofti abundant larval transcript recognized in natural infection. | lymphatic filariasis is a tropical disease, with over 40 million people seriously incapacitated due to lymphangitis and elephantiasis. over 99% of infections are caused by the nematode wuchereria bancrofti. expressed sequence tag (est) analysis of filarial genome identified novel infective larval (l3) stage-specific antigen, abundant larval transcript (alt-2), which was shown to be highly essential for parasite establishment and survival in the host. the unique structural features and immunologi ... | 2010 | 20803227 |
| post-kidney transplantation lymphocele due to a lymphatic filariasis. | lymphocele is a well-known complication of renal transplantation. presenting symptoms are nonspecific; most patients are entirely asymptomatic. herein, we have reported a case of lymphocele due to an asymptomatic lymphatic wuchereria bancrofti filariasis with deterioration of graft function. a 53-year-old man with end-stage renal disease secondary to vascular disease was admitted 40 days after transplantation with vague, isolated abdominal pain. an abdomen and pelvis ultrasound examination demon ... | 2010 | 20832594 |
| filarial labial chylorrhoea: an uncommon problem in an endemic region. | 2010 | 20845300 | |
| elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections. | lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (vegfs). a panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longst ... | 2010 | 20889885 |
| up-regulation of lipophorin (lp) and lipophorin receptor (lpr) gene in the mosquito, culex quinquefasciatus (diptera: culicidae), infected with the filarial parasite, wuchereria bancrofti (spirurida: onchocercidae). | in mosquitoes, including culex quinquefasciatus, immune molecules are known to be upregulated or produced de novo upon exposure to parasites or pathogens. these molecules are regulatory in nature acting against parasite or pathogen infection and development. similarly, there are molecules that are upregulated to facilitate parasite development in the vector mosquitoes. lipophorin, a major lipid transporting lipoprotein in the hemolymph of insects, is implicated as a helper molecule in the clotti ... | 2010 | 20922426 |
| effect of a single dose of diethylcarbamazine, albendazole or both on the clearance of wuchereria bancrofti microfilariae and antigenaemia among microfilaria carriers: a randomized trial. | lymphatic filariasis is a major vector-borne parasitic disease. the global programme to eliminate lymphatic filariasis was launched in 1997 and currently over 570 million people are covered under it in 48 countries. mass annual single-dose drug administration of diethylcarbamazine (dec), co-administrated with albendazole for 5-6 years and mass distribution of diethylcarbamazine-fortified salt are the two strategies for elimination of filariasis. | 2010 | 20925201 |
| pathogenomics of culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens. | the mosquito culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of west nile virus (wnv), the filarial worm wuchereria bancrofti, and an avian malaria parasite. comparative phylogenomics revealed an expanded canonical c. quinquefasciatus immune gene repertoire compared with those of aedes aegypti and anopheles gambiae. transcriptomic analysis of c. quinquefasciatus genes responsive to wnv, w. bancrofti, and non-native bacteria facilitated an unpr ... | 2010 | 20929811 |
| improving community participation to eliminate lymphatic filariasis in american samoa. | in 2000, the american samoa department of health initiated a campaign of annual mass drug administration (mda) with albendazole and diethylcarbamazine (dec) to eliminate transmission of filariasis. drug coverage was well below prescribed targets in the first three campaigns, ranging from 24 to 52% of the total population. evaluation findings from a variety of formative research methods identified opportunities to improve mda coverage and ensuing program modifications resulted in increased drug c ... | 2010 | 20932818 |
| evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of wuchereria bancrofti infection using multiple infection parameters. | objectives: to evaluate the effect of multiple rounds of annual single dose of dec (6mg/kg) or albendazole (400mg) given alone or in combination on wuchereria bancrofti microfilaraemia, anti-filarial igg1 and igg4 and antigenaemia. methods: a total of 170 participants were randomly assigned to albendazole (n=62), dec (n=54), and dec plus albendazole (dec/alb) combination (n=54). blood samples were collected at pre-treatment in 1998, at 1 week and 6 months after the first treatment and thereafter ... | 2010 | 20933491 |
| [filaria]. | 2010 | 20942062 | |
| expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower ccr1 expression. | apc dysfunction has been postulated to mediate some of the parasite-specific t cell unresponsiveness seen in patent filarial infection. we have shown that live microfilariae of brugia malayi induce caspase-dependent apoptosis in human monocyte-derived dendritic cells (dcs) in vitro. this study addresses whether apoptosis observed in vitro extends to patent filarial infections in humans and is reflected in the number of circulating myeloid dcs (mdcs; cd11c(-)cd123(lo)) in peripheral blood of infe ... | 2010 | 20956349 |
| microfilaria in malignant pleural effusion: an unusual association. | lymphatic filariasis is common in tropical countries and is endemic in india. filariasis presenting with pleural effusion is an unusual presentation. malignancy in association of filarial pleural effusion is extremely rare. we report a case of a 60-year-old female who presented with chest pain, loss of weight and breathlessness for a few months. pleural fluid examination revealed malignant cells, along with microfilaria of wuchereria bancrofti. | 2010 | 20966579 |
| toward molecular parasitologic diagnosis: enhanced diagnostic sensitivity for filarial infections in mobile populations. | the diagnosis of filarial infections among individuals residing in areas where the disease is not endemic requires both strong clinical suspicion and expert training in infrequently practiced parasitological methods. recently developed filarial molecular diagnostic assays are highly sensitive and specific but have limited availability and have not been closely evaluated for clinical use outside populations residing in areas of endemicity. in this study, we assessed the performance of a panel of ... | 2010 | 20980560 |
| the migration of infective larvae of wuchereria bancrofti within the mosquito host and their rate of escape under laboratory conditions. | 1946 | 20990871 | |
| experiments to determine potential mosquito vectors of wuchereria bancrofti in the continental united states, part 2. | 1946 | 21003276 | |
| studies of filariasis; development of wuchereria bancrofti in culex quinquefasciatus of oahu. | 1946 | 21003277 | |
| tropical diseases with special reference to filariasis (wuchereria bancrofti). | 1945 | 21003947 | |
| observations on the specificity and clinical use of dirofilaria immitis antigen in the diagnosis of human filariasis (wuchereria bancrofti). | 1946 | 21009777 | |
| observations on the incidence of wuchereria bancrofti larvae in the native population of the solomon islands area. | 1945 | 21010816 | |
| chemotherapy of filariasis due to wuchereria bancrofti with neostibosan. | 1946 | 21018328 | |
| studies on filariasis; serological relationships between antigenic extracts of wuchereria bancrofti and dirofilaria immitis. | 1946 | 21018330 | |
| observations on two cases of human filariasis (wuchereria bancrofti and mansonella ozzardi). | 1946 | 21019186 | |
| studies on filariasis; potential mosquito vectors of wuchereria bancrofti. | 1946 | 21020565 | |
| use of high-dose, twice-yearly albendazole and ivermectin to suppress wuchereria bancrofti microfilarial levels. | annual mass treatment with albendazole and ivermectin is the mainstay of current strategies to interrupt transmission of wuchereria bancrofti in africa. more-effective microfilarial suppression could potentially reduce the time necessary to interrupt transmission, easing the economic burden of mass treatment programs in countries with limited resources. | 2010 | 21039220 |
| higher-dose, more frequent treatment of wuchereria bancrofti. | 2010 | 21039221 | |
| adult filarial worm by fine needle aspiration cytology of breast lumps. | 2010 | 21053616 | |
| a note on anopheline vectors of wuchereria bancrofti in west africa. | 1946 | 21066379 | |
| midgut barrier imparts selective resistance to filarial worm infection in culex pipiens pipiens. | mosquitoes in the culex pipiens complex thrive in temperate and tropical regions worldwide, and serve as efficient vectors of bancroftian lymphatic filariasis (lf) caused by wuchereria bancrofti in asia, africa, the west indies, south america, and micronesia. however, members of this mosquito complex do not act as natural vectors for brugian lf caused by brugia malayi, or for the cat parasite b. pahangi, despite their presence in south asia where these parasites are endemic. previous work with t ... | 2010 | 21072236 |
| a single dose of doxycycline in combination with diethylcarbamazine for treatment of bancroftian filariasis. | standard treatment of lymphatic filariasis with diethylcarbamazine (dec) is associated with systemic adverse reactions, thought to be due to the release of microfilariae material and wolbachia endosymbiotic bacteria into the blood. combination treatments with doxycycline for 3-8 weeks are more effective than standard treatment. however, long-term use of antibiotics may contribute to drug resistance and are not practical for use in remote areas. we assessed whether a single dose of doxycycline co ... | 2010 | 21073054 |
| touchdown-touchup nested pcr for low-copy gene detection of benzimidazole-susceptible wuchereria bancrofti with a wolbachia endosymbiont imported by migrant carriers. | a novel, sensitive and specific touchdown-touchup nested pcr (tnpcr) technique based on two useful molecular markers, a wuchereria bancrofti β-tubulin gene involved in benzimidazole susceptibility and a wolbachia ftsz gene involved in cell division, was developed to simultaneously detect the parasite w. bancrofti (w1) with its wolbachia endosymbiont (w2) from both microfilaremic and post-treatment samples of at-risk migrant carriers infected with geographical w. bancrofti isolates. the detection ... | 2010 | 21074526 |
| evaluation of synthetic peptides of wbsxp-1 for the diagnosis of human lymphatic filariasis. | parasitic nematodes infect nearly half of the world's human population, resulting in significant morbidity and mortality. though filariasis is not fatal, it is the second leading cause of permanent and long-term disability worldwide. filariasis has a spectrum of disease manifestation and infectivity found among the infected individuals and also goes unnoticed for years. furthermore, there are ample reports emerging on the genetic variation among the parasites population. hence, it is necessary t ... | 2010 | 21094425 |
| incidental detection of filaria in fine-needle aspirates: a cytologic study of 14 clinically unsuspected cases at different sites. | filariasis is a major health problem in tropical countries like india. detection of microfilariae or adult worm or egg in fnac is very unusual despite the high incidence of this parasite in endemic zone. the aim of this study was to document the value of fine-needle aspiration cytology (fnac) in diagnosis of filaria at all possible sites presenting as mass or swelling.fourteen patients (nine males and five females) in the age range of 14-61 years were subjected to fnac. fna from swellings was do ... | 2010 | 21104843 |
| high prevalence of wuchereria bancrofti infection as detected by immunochromatographic card testing in five districts of orissa, india, previously considered to be non-endemic. | india accounts for over one-third of the world's burden of lymphatic filariasis (lf). although most coastal districts of orissa state (eastern india) are lf-endemic, the western districts of orissa are considered non-endemic. during a large-scale insecticide-treated bed net/microfinance trial, we tested one randomly selected adult (age 15-60 years) for lf from a random sample of microfinance-member households in five districts of western orissa, using immunochromatographic card testing (ict). ov ... | 2010 | 21122883 |
| a foray for filaria. | 2010 | 21143068 | |
| first evidence of spatial clustering of lymphatic filariasis in an aedes polynesiensis endemic area. | successful elimination of lymphatic filariasis (lf) requires accurate identification of residual foci of transmission and stringent surveillance strategies to combat potential resurgence. this is challenging in areas where the day-biting aedes polynesiensis is endemic, such as samoa, since in previous studies no geographical clustering of infection has been demonstrated. another challenge for this low prevalence phase is the choice of diagnostic assay as testing for circulating filarial antigen ... | 2010 | 21172296 |
| lymphedema in a guyanan migrant. | 2010 | 21199149 | |
| biochemical studies on glutathione s-transferase from the bovine filarial worm setaria digitata. | setaria digitata is a filarial worm of the cattle used as a model system for antifilarial drug screening, due to its similarity to the human filarial parasites wuchereria bancrofti and brugia malayi. since filarial glutathione s-transferase (gst) is a good biochemical target for antifilarial drug development, a study has been undertaken for the biochemical characterization of gst from s. digitata. cytosolic fraction was separated from the crude s.digitata worm homogenate by ultracentrifugation a ... | 2011 | 21207063 |
| absence of lymphatic filariasis infection among secondary-school children in oman. | the endemicity status of lymphatic filariasis in oman is uncertain, with only sporadic cases reported, mostly imported. immunochromatographic card test surveys were carried out to assess the presence of circulating wuchereria bancrofti antigenaemia as a marker for active infection in children from suspected high-risk areas of oman (south batinah and dhofar). lot quality assurance sampling surveys were carried out on a minimum of 250 secondary-school children aged 17-18 years in each of 8 distric ... | 2010 | 21222423 |
| bancroftian elephantiasis in nilphamari, bangladesh. | the parasitic nematodes wuchereria bancrofti, causes a dreadful disease in humans known as lymphatic filariasis, which afflicts more than 250 million people in tropical countries. twelve districts with about 20 million people are endemic out of 64 districts in bangladesh affecting more on northern districts. this study was done in the nilphamari, kisorgonj and sayedpur thana under nilphamari district, which is the most endemic for filariasis. in the present study, nineteen unions were investigat ... | 2011 | 21240161 |
| characterization of the dmae-modified juvenile excretory-secretory protein juv-p120 of litomosoides sigmodontis. | juv-p120 is an excretory-secretory 160 kda glycoprotein of juvenile female litomosoides sigmodontis and exhibits features typical for mucins. 50% of its molecular mass is attributed to posttranslational modifications with the unusual substituent dimethylaminoethanol (dmae). by that juv-p120 corresponds to the surface proteins of the microfilarial sheath, shp3 and shp3a. the secreted protein consists of 697 amino acids, organized in two different domains of repeat elements separated by a stretch ... | 2011 | 21241743 |
| diurnally subperiodic filariasis in india-prospects of elimination: precept to action? | the elimination of lymphatic filariasis in the andaman and nicobar islands provides unique opportunities and challenges at the same time. since these islands are remote, are sparsely populated, and have poor transport networks, mass drug administration programs are likely to be difficult to implement. diurnally subperiodic wuchereria bancrofti vectored by downsiomyia nivea was considered for the scope of vector control options. considering the bioecology of this mosquito, vector control includin ... | 2011 | 21286754 |
| description of the parasite wucheria bancrofti microfilariae identified in follicular fluid following transvaginal oocyte retrieval. | this case study presents an unusual finding of filarial infection within follicular fluid obtained during an in vitro fertilization (ivf) oocyte retrieval procedure. | 2011 | 21287402 |
| filarial worms reduce plasmodium infectivity in mosquitoes. | co-occurrence of malaria and filarial worm parasites has been reported, but little is known about the interaction between filarial worm and malaria parasites with the same anopheles vector. herein, we present data evaluating the interaction between wuchereria bancrofti and anopheles punctulatus in papua new guinea (png). our field studies in png demonstrated that an. punctulatus utilizes the melanization immune response as a natural mechanism of filarial worm resistance against invading w. bancr ... | 2011 | 21347449 |