Publications

TitleAbstractYear
Filter
PMID(sorted ascending)
Filter
the effects of regular hot black tea consumption on nasal carriage of methicillin-resistant staphylococcus aureus.this study aims to evaluate the possible relationship between oral consumption of hot black tea and methicillin-resistant staphylococcus aureus (mrsa) nasal carriage in a mid-sized town population in central anatolia.201425010803
green tea, black tea, and oolong tea polyphenols reduce visceral fat and inflammation in mice fed high-fat, high-sucrose obesogenic diets.green tea (gt) and caffeine in combination were shown to increase energy expenditure and fat oxidation, but less is known about the effects of black tea (bt) and oolong tea (ot). this study investigated whether decaffeinated polyphenol extracts from gt, bt, and ot decrease body fat and inflammation in male c57bl/6j mice fed high-fat/high-sucrose [hf/hs (32% energy from fat, 25% energy from sucrose)] diets. mice were fed either an hf/hs diet with 0.25% of polyphenol from gt, ot, or bt or a low-fa ...201425031332
relationship between bladder cancer and total fluid intake: a meta-analysis of epidemiological evidence.epidemiological findings regarding the association between total fluid intake and bladder cancer risk have yielded varying results. our objective is to examine the possible associations between total fluid intake and bladder cancer risk.201425033957
fermentation characteristics, tannin contents and in vitro ruminal degradation of green tea and black tea by-products ensiled at different temperatures.green and black tea by-products, obtained from ready-made tea industry, were ensiled at 10°c, 20°c, and 30°c. green tea by-product silage (gts) and black tea by-product silage (bts) were opened at 5, 10, 45 days after ensiling. fermentation characteristics and nutrient composition, including tannins, were monitored and the silages on day 45 were subjected to in vitro ruminal fermentation to assess anti-nutritive effects of tannins using polyethylene glycol (peg) as a tannin-binding agent. result ...201425050034
investigation of processes in black tea manufacture through model fermentation (oxidation) experiments.flavanol depleted whole fresh green tea leaf powder, as reported in the literature, was used as matrix for a systematic study of the endogenous oxidative enzymatic conversion of selected flavanol combinations to theaflavins and thearubigins. the activity of the two crucial enzymes polyphenol oxidase (ppo) and peroxidase (pod) was controlled individually through addition of h2o2 and/or o2. using the endogenous peroxidase only it was shown that (-)-epicatechin alone did not react with pod. accordi ...201425051300
a stress-responsive late embryogenesis abundant protein 7 (cslea7) of tea [camellia sinensis (l.) o. kuntze] encodes for a chaperone that imparts tolerance to escherichia coli against stresses.the present study characterized cslea7, a group 7 late embryogenesis abundant (lea) gene, from tea [camellia sinensis (l.) o. kuntze]. the gene had an open reading frame of 462 base pairs encoding 153 amino acids with calculated molecular weight of 16.63 kda and an isoelectric point (pi) of 4.93. analysis revealed cslea7 to be an intrinsically ordered protein consisting of nine β-strands and two α-helices. cslea7 expressed ubiquitously in all the tissues analyzed with highest level of transcript ...201425052187
the effect of iron and fat in a diet containing green tea extract (camellia sinensis) on the antioxidant capacity of some organs and the mrna expression of specific genes in mice.the hypothesis that iron and fat in the diet may affect green tea extract (gte) bioactivity, in particular antioxidant capacity and gene expression, was proposed and tested in mice. thirty mice were randomly assigned to have for 37 days free access to standard or high-fat diets with or without gte and ferrous lactate. mice were euthanized and specific organs were removed. total antioxidant capacity (tac) was measured using the ferric reducing antioxidant power (frap) and oxygen radical absorbanc ...201425055080
overexpression of camellia sinensis h1 histone gene confers abiotic stress tolerance in transgenic tobacco.overexpression of cshis in tobacco promoted chromatin condensation, but did not affect the phenotype. it also conferred tolerance to low-temperature, high-salinity, aba, drought and oxidative stress in transgenic tobacco. h1 histone, as a major structural protein of higher-order chromatin, is associated with stress responses in plants. here, we describe the functions of the camellia sinensis h1 histone gene (cshis) to illustrate its roles in plant responses to stresses. subcellular localization ...201425063323
occurrence of glycosidically conjugated 1-phenylethanol and its hydrolase β-primeverosidase in tea (camellia sinensis) flowers.a previous study found that 1-phenylethanol (1pe) was a major endogenous volatile compound in tea (camellia sinensis) flowers and can be transformed to glycosically conjugated 1pe (1pe-gly). however, occurrences of 1pe-gly in plants remain unknown. in this study, four 1pe-glys have been isolated from tea flowers. three of them were determined as (r)-1pe β-d-glucopyranoside ((r)-1pe-glu), (s)-1pe-glu, and (s)-1pe β-primeveroside ((s)-1pe-pri), respectively, on the basis of nmr, ms, lc-ms, and gc- ...201425065942
effect of plant extracts on h2o2-induced inflammatory gene expression in macrophages.arctium lappa (al), camellia sinensis (cs), echinacea angustifolia, eleutherococcus senticosus, panax ginseng (pg), and vaccinium myrtillus (vm) are plants traditionally used in many herbal formulations for the treatment of various conditions. although they are well known and already studied for their anti-inflammatory properties, their effects on h2o2-stimulated macrophages are a novel area of study.201425075197
meta-analysis of black tea consumption and breast cancer risk: update 2013.black tea is a commonly consumed beverage in the world, comprising approximately 80% of all tea consumed. we sought to examine the association between black tea consumption and risk of breast cancer, using all available epidemiologic evidence to date. pubmed, embase, isi web of science, chinese national knowledge infrastructure database, and china biological medicine database were used to search for citations using the mesh terms as "breast neoplasm" and "black tea." then we performed a meta-ana ...201425077380
the effect of black tea on blood pressure: a systematic review with meta-analysis of randomized controlled trials.epidemiological evidence has linked consumption of black tea, produced from camellia sinensis, with a reduced risk of cardiovascular diseases. however, intervention studies on the effects of tea consumption on blood pressure (bp) have reported inconsistent results. our objective was to conduct a systematic literature review with meta-analysis of controlled human intervention studies examining the effect of tea consumption on bp.201425079225
plant growth-promoting rhizobacterial strain-mediated induced systemic resistance in tea (camellia sinensis (l.) o. kuntze) through defense-related enzymes against brown root rot and charcoal stump rot.induction of systemic resistance in host plants through microbes and their bioactive metabolites are attaining popularity in modern agricultural practices. in this regard, individual application of two strains of pseudomonas, rrlj 134 and rrlj 04, exhibited development of induced systemic resistance in tea plants against brown root rot and charcoal stump rot under split root experiments. the experimental findings also confirmed that the cuttings treated with fungal test pathogen and plant growth ...201425082766
rutin attenuates ethanol-induced neurotoxicity in hippocampal neuronal cells by increasing aldehyde dehydrogenase 2.rutin is derived from buckwheat, apples, and black tea. it has been shown to have beneficial anti-inflammatory and antioxidant effects. ethanol is a central nervous system depressant and neurotoxin. its metabolite, acetaldehyde, is critically toxic. aldehyde dehydrogenase 2 (aldh2) metabolizes acetaldehyde into nontoxic acetate. this study examined rutin's effects on aldh2 activity in hippocampal neuronal cells (ht22 cells). rutin's protective effects against acetaldehyde-based ethanol neurotoxi ...201425084483
rna-seq-mediated transcriptome analysis of actively growing and winter dormant shoots identifies non-deciduous habit of evergreen tree tea during winters.tea [camellia sinensis (l.) o. kuntze] is a perennial tree which undergoes winter dormancy and unlike deciduous trees, the species does not shed its leaves during winters. the present work dissected the molecular processes operating in the leaves during the period of active growth and winter dormancy through transcriptome analysis to understand a long-standing question: why should tea be a non-deciduous species? analyses of 24,700 unigenes obtained from 57,767 primarily assembled transcripts sho ...201425090269
molecular cloning and expression analysis of tea plant aquaporin (aqp) gene family.the role of aquaporin proteins (aqps) has been extensively studied in plants. however, the information of aqps in the tea plant (camellia sinensis) is unclear. in this manuscript, we isolated 20 full-length aqp cdnas from the tea plant, and these sequences were classified into five subfamilies. the genes in these subfamilies displayed differential expression profiles in the studied tissues. the csaqp expression patterns correlated with flower development and opening (fdo) and bud endodormancy (b ...201425093260
oolong, black and pu-erh tea suppresses adiposity in mice via activation of amp-activated protein kinase.it is well known that tea has a variety of beneficial impacts on human health, including anti-obesity effects. it is well documented that green tea and its constituent catechins suppress obesity, but the effects of other types of tea on obesity and the potential mechanisms involved are not yet fully understood. in this study, we investigated the suppression of adiposity by oolong, black and pu-erh tea and characterized the underlying molecular mechanism in vivo. we found that the consumption of ...201425098399
simultaneous and enantioselective determination of cis-epoxiconazole and indoxacarb residues in various teas, tea infusion and soil samples by chiral high performance liquid chromatography coupled with tandem quadrupole-time-of-flight mass spectrometry.a novel and sensitive method for simultaneous enantiomeric analysis of two pesticides-cis-epoxiconazole and indoxacarb-in various teas, black tea infusion, and soil samples has been developed. the samples were initially subjected to acetonitrile extraction followed by cleanup using lab-made florisil/graphitized carbon black mixed solid phase extraction (spe) column (for the different teas and soil samples) and a bondelut c18-spe column (for the black tea infusion samples). separation of the anal ...201425108768
effects of a pre-and post-workout protein-carbohydrate supplement in trained crossfit individuals.the purpose was to assess effects of a pre- and a post-workout protein-carbohydrate supplement on crossfit-specific performance and body composition.201425110627
epigalloccatechin-3-gallate inhibits ocular neovascularization and vascular permeability in human retinal pigment epithelial and human retinal microvascular endothelial cells via suppression of mmp-9 and vegf activation.epigalloccatechin-3-gallate (egcg) is the main polyphenol component of green tea (leaves of camellia sinensis). egcg is known for its antioxidant, anti-inflammatory, antiviral, and anti-carcinogenic properties. here, we identify egcg as a new inhibitor of ocular angiogenesis and its vascular permeability. matrix metalloproteinases (mmps) and vascular endothelial growth factor (vegf) play a key role in the processes of extracellular matrix (ecm) remodeling and microvascular permeability during an ...201425123184
metabolic engineering of saccharomyces cerevisiae for caffeine and theobromine production.caffeine (1, 3, 7-trimethylxanthine) and theobromine (3, 7-dimethylxanthine) are the major purine alkaloids in plants, e.g., tea (camellia sinensis) and coffee (coffea arabica). caffeine is a major component of coffee and is used widely in food and beverage industries. most of the enzymes involved in the caffeine biosynthetic pathway have been reported previously. here, we demonstrated the biosynthesis of caffeine (0.38 mg/l) by co-expression of coffea arabica xanthosine methyltransferase (caxmt ...201425133732
effects of tea intake on blood pressure: a meta-analysis of randomised controlled trials.the effect of tea intake on blood pressure (bp) is controversial. we performed a meta-analysis of randomised controlled trials to determine the changes in systolic and diastolic bp due to the intake of black and green tea. a systematic search was conducted in medline, embase and the cochrane controlled trials register up to may 2014. the weighted mean difference was calculated for net changes in systolic and diastolic bp using fixed-effects or random-effects models. previously defined subgroup a ...201425137341
fractionation and identification of minor and aroma-active constituents in kangra orthodox black tea.the aroma constituents of kangra orthodox black tea were isolated by simultaneous distillation extraction (sde), supercritical fluid extraction and beverage method. the aroma-active compounds were identified using gas chromatography-olfactometry-mass spectrometry. geraniol, linalool, (z/e)-linalool oxides, (e)-2-hexenal, phytol, β-ionone, hotrienol, methylpyrazine and methyl salicylate were major volatile constituents in all the extracts. minor volatile compounds in all the extracts were 2-ethyl ...201525148991
histochemical evaluation of catechins in peg stressed transgenic tea plants using catechin-specific-diazotized sulfanilamide reagent.we investigated the applicability of catechin-specific-reagent (csr) for histochemical evaluation of catechins. the diazotized arylamine moiety in csr reacts specifically with the a-ring of catechins to yield a golden yellow complex. this makes it highly specific for spectrophotometric quantification of catechins. therefore, microtome cut sections of untransformed and osmotin-expressing transgenic leaves and stem of tea were stained with csr. we found catechins in the form of golden yellow globu ...201525151989
black hairy tongue syndrome.black hairy tongue (bht) is a benign medical condition characterized by elongated filiform lingual papillae with typical carpet-like appearance of the dorsum of the tongue. its prevalence varies geographically, typically ranging from 0.6% to 11.3%. known predisposing factors include smoking, excessive coffee/black tea consumption, poor oral hygiene, trigeminal neuralgia, general debilitation, xerostomia, and medication use. clinical presentation varies but is typically asymptomatic, although aes ...201425152586
tea derived galloylated polyphenols cross-link purified gastrointestinal mucins.polyphenols derived from tea are thought to be important for human health. we show using a combination of particle tracking microrheology and small-angle neutron scattering that polyphenols acts as cross-linkers for purified gastrointestinal mucin, derived from the stomach and the duodenum. both naturally derived purified polyphenols, and green and black tea extracts are shown to act as cross-linkers. the main active cross-linking component is found to be the galloylated forms of catechins. the ...201425162539
residues and contaminants in tea and tea infusions: a review.consumers are very aware of contaminants that could pose potential health hazards. most people drink tea as an infusion (adding hot water); however, in some countries, including india, china and egypt, tea is drunk as a decoction (tea and water are boiled together). an infusion usually brings the soluble ingredients into solution, whereas a decoction brings all soluble and non-soluble constituents together. therefore, a cup of tea may contain various kinds of contaminants. this review focuses on ...201425164107
extraction characteristics of subcritical water depending on the number of hydroxyl group in flavonols.this study compared the efficiencies of using subcritical water, hot water, and organic solvents to extract flavonols from black tea, celery, and ginseng leaf. the effect of key operating conditions was determined by varying the temperature (110-200°c), extraction time (5-15min), and pressure (about 10mpa) and the extracts were analysed quantitatively using hplc. the yields of myricetin, quercetin, and kaempferol from plants were maximal at extraction temperatures of 170°c, 170°c and 200°c, resp ...201525172678
antimutagenic and anticancer activity of darjeeling tea in multiple test systems.darjeeling tea, a most popular variety of black tea, though consumed by the people in different parts of world but its beneficial health effects have not been investigated in details. in this study, the antimutagenic and anticancer effect of darjeeling tea extract (dte) has been evaluated.201425183356
occurrence of 15 + 1 eu priority polycyclic aromatic hydrocarbons (pah) in various types of tea (camellia sinensis) and herbal infusions.for the analysis of 15 + 1 eu priority pah in tea and herbal infusions, an online-spe-lvi-gc-ms method was developed. this method includes sample extraction of the tea and herbal infusions with saponification followed by an automated spe clean-up step. for brews a liquid-liquid extraction with cyclohexane was performed before an automated spe clean-up. gas chromatographic separation was done using an agilent j&w select pah (15 m × 0.15 mm × 0.10 µm) column, which allows the separation of the thr ...201425186127
the antimicrobial possibilities of green tea.green tea is a popular drink, especially in asian countries, although its popularity continues to spread across the globe. the health benefits of green tea, derived from the leaves of the camellia sinensis plant, have been studied for many years. fairly recently, researchers have begun to look at the possibility of using green tea in antimicrobial therapy, and the potential prevention of infections. the particular properties of catechins found in the tea have shown promise for having antimicrobi ...201425191312
tea consumption and lung cancer risk: a meta-analysis of case-control and cohort studies.recent epidemiologic studies, especially cohort and case-control studies, have yielded inconsistent findings regarding the association between tea consumption and risk for lung cancer. the aim of this study was to assess a potential relationship between tea consumption and the incidence of lung cancer worldwide.201425194612
determination of catechin content in representative chinese tea germplasms.to understand tea germplasms better and to use them effectively for production and breeding, the catechin content of 403 accessions of representative tea germplasms collected from various locations in china were studied using hplc. the catechin content of these tea germplasms varied from 56.6 to 231.9 mg/g and averaged 154.5 ± 18.1 mg/g. one germplasm with low total catechin (tc) content (<60 mg/g) and three with high tc (>200 mg/g) contents were found. averages of the tc content of the three va ...201425204786
effect of hydro-alcoholic root extract of plumbago zeylanica l alone and its combination with aqueous leaf extract of camellia sinensis on haloperidol induced parkinsonism in wistar rats.herbal medicines have been used to treat pd in ancient medical systems in asian countries such as india, china, japan and korea based on their own anecdotal or experience-based theories. mucuna pruriens commonly known asvelvet beans, or cow itch, are used in case of spasms associated with parkinsonism.201425206060
discrimination of chinese teas with different fermentation degrees by stepwise linear discriminant analysis (s-lda) of the chemical compounds.this study aimed to construct objective and accurate analytical models of tea categories based on their polyphenols and caffeine. a total of 522 tea samples of 4 commonly consumed teas with different fermentation degrees (green tea, white tea, oolong tea, and black tea) were analyzed by high-performance liquid chromatography (hplc) coupled with spectrophotometry, utilizing iso 14502, as analytical tools. the content of polyphenols and caffeine varied significantly according to differently fermen ...201425211192
melatonin contents in mulberry (morus spp.) leaves: effects of sample preparation, cultivar, leaf age and tea processing.the effects of sample preparation, cultivar, leaf age and tea processing on melatonin content of mulberry (morus spp.) leaves were investigated. sample preparation using ultrasonic technique in combination with solid phase extraction resulted in high recovery rate (76%), when compared to homogenisation in combination with liquid-liquid extraction procedure (12% recovery rate). the melatonin contents in mulberry leaves harvested from three major cultivars (buriram 60, sakonnakhon and khunphai) gr ...201125212150
enzymatic treatment to improve the quality of black tea extracts.enzymatic extraction was investigated to improve the quality of black tea extracts with pretreatment of pectinase and tannase independently, successively and simultaneously. pectinase improved the extractable-solids-yield (esy) up to 11.5%, without much of an improvement in polyphenols recovery, while tannase pre-treatment showed a significant improvement in polyphenols recovery (14.3%) along with an 11.1% improvement in esy. among the four treatments, tannase-alone treatment showed the maximum ...201125214094
antioxidant activity prediction and classification of some teas using artificial neural networks.in order to characterise and to classify some teas a simple, rapid and economical method based on composition, antioxidant activity and artificial neural networks (anns) is proposed. for these purpose two types of ann based applications have been developed: one for predicting the antioxidant activity and a second one for establishing the class of the teas. the complex relationship between the total antioxidant activity (aa) depending on the total flavonoids content (f), total catechins content ( ...201125214133
transcriptome analysis of indole-3-butyric acid-induced adventitious root formation in nodal cuttings of camellia sinensis (l.).tea (camellia sinensis l.) is a popular world beverage, and propagation of tea plants chiefly depends on the formation of adventitious roots in cuttings. to better understand potential mechanisms involved in adventitious root formation, we performed transcriptome analysis of single nodal cuttings of c. sinensis treated with or without indole-3-butyric acid (iba) using the illumina sequencing method. totally 42.5 million rna-seq reads were obtained and these were assembled into 59,931 unigenes, w ...201425216187
cytochrome p450 3a4 and 2d6-mediated metabolism of leisure and medicinal teas.thirty-five commercially available camellia sinensis (black and green) and herbal leisure teas and an assortment of traditional chinese medicinal teas were randomly selected and examined for their potential to inhibit the drug metabolizing enzyme cytochrome p450 3a4 (cyp3a4). the study was then extended to examine cyp2d6*1 and cyp2d6*10.201425224344
tmdb: a literature-curated database for small molecular compounds found from tea.tea is one of the most consumed beverages worldwide. the healthy effects of tea are attributed to a wealthy of different chemical components from tea. thousands of studies on the chemical constituents of tea had been reported. however, data from these individual reports have not been collected into a single database. the lack of a curated database of related information limits research in this field, and thus a cohesive database system should necessarily be constructed for data deposit and furth ...201425224438
metabolic stability and inhibitory effect of o-methylated theaflavins on h2o2-induced oxidative damage in human hepg2 cells.seven new o-methylated theaflavins (tfs) were synthesized by using o-methyltransferase from an edible mushroom. using tfs and o-methylated tfs, metabolic stability in pooled human liver s9 fractions and inhibitory effect on h(2)o(2)-induced oxidative damage in human hepg2 cells were investigated. in o-methylation of theaflavin 3'-o-gallate (tf3'g), metabolic stability was potentiated by an increase in the number of introduced methyl groups. o-methylation of tf3,3'g did not affect metabolic stabi ...201425229848
new phenylpropanoid-substituted flavan-3-ols from pu-er ripe tea.pu-er ripe tea is a special microbial post-fermented tea made from pu-er raw tea, a kind of green tea produced from the leaves of camellia sinensis var. assamica. it is one of the most consumed teas in the past two decades in china, due to its special flavor, taste, and beneficial effects. this work aimed to obtain diverse catechin structures from pu-er ripe tea, which led to the isolation of four new phenylpropanoid-substituted flavan-3-ols, puerins c-f (1-4), together with four known flavan-3- ...201425233599
warfarin interactions with medicinal herbs.recognition of the adverse effects of medicinal herbs is not routine and the reports on such effects are even less frequent in clinical practice. potential herb-drug interactions are of a major safety concern, especially for drugs with narrow therapeutic indices like warfarin, which can lead to severe adverse reactions that are sometimes life-threatening. the interactions between warfarin and medicinal herbs described in the literature have been summarized in this paper relying on medline databa ...201425233607
simulated gastrointestinal digestion, intestinal permeation and plasma protein interaction of white, green, and black tea polyphenols.the gastrointestinal digestion, intestinal permeation, and plasma protein interaction of polyphenols from a single tea cultivar at different stages of processing (white, green, and black teas) were simulated. the salivary phase contained 74.8-99.5% of native polyphenols, suggesting potential bioavailability of significant amounts of antioxidants through the oral mucosal epithelium that might be gastric sensitive and/or poorly absorbed in the intestine. white tea had the highest content and provi ...201525236233
white tea (camellia sinensis) inhibits proliferation of the colon cancer cell line, ht-29, activates caspases and protects dna of normal cells against oxidative damage.tea (camellia sinensis) is one of the most consumed beverages in the world. white tea is made from the buds and young leaves of the tea plant which are steamed and dried, whilst undergoing minimal oxidation. the mtt assay was used to test the extract on the effect of the proliferation of the colorectal cancer cell line, ht-29. the extract inhibited the proliferation of ht-29 cells with an ic50 of 87μg/ml. the extract increased the levels of caspase-3, -8, and -9 activity in the cells. dna damage ...201525236244
effect of black tea consumption on blood cholesterol: a meta-analysis of 15 randomized controlled trials.the results of the studies that have investigated the effects of black tea on blood cholesterol are inconsistent. the aim of this study is to quantitatively assess the effects of black tea on cholesterol concentrations.201425237889
a phase ii clinical trial of a natural formulation containing tea catechins for xerostomia.previous animal studies indicated catechins from the tea plant (camellia sinensis) may modulate salivary function and possess a therapeutic effect for xerostomia. the objective of this study was to evaluate a natural formulation containing tea catechins in 60 patients with xerostomia, including patients with sjögren syndrome.201425240992
comparison of the inhibition of monoamine oxidase and butyrylcholinesterase activities by infusions from green tea and some citrus peels.this study sought to investigate the effect of infusions from green tea (camellia sinensis) and some citrus peels [shaddock (citrus maxima), grapefruit (citrus paradisi), and orange (citrus sinensis)] on key enzymes relevant to the management of neurodegenerative conditions [monoamine oxidase (mao) and butyrylcholinesterase (bche)]. the total phenol contents and antioxidant activities as typified by their 2,2(')-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (abts) radicals scavenging abiliti ...201425243093
the galloyl catechins contributing to main antioxidant capacity of tea made from camellia sinensis in china.total polyphenol content, catechins content, and antioxidant capacities of green, dark, oolong, and black teas made from camellia sinensis in china were evaluated. the total polyphenol content of 20 samples of tea was in the range of 7.82-32.36%. total catechins content was in the range of 4.34-24.27%. the antioxidant capacity of tea extract was determined by the oxygen radical absorbance capacity (orac) test and the 1,1-diphenyl-2-picrylhydrazyl (dpph) radical-scavenging test. total polyphenol ...201425243234
theaflavins inhibit pathogenic properties of p. gingivalis and mmps production in p. gingivalis-stimulated human gingival fibroblasts.theaflavins, the main polyphenols in black tea, possesses a wide range of beneficial pharmacological properties. porphyromonas gingivalis (p. gingivalis) is a major aetiological agent associated with periodontitis, a chronic inflammatory disease affecting tooth-supporting tissues. the aim of the present study is to investigate the effect of theaflavins on pathogenic properties of p. gingivalis and on periodontitis by inhibiting matrix metalloproteinases (mmps) production induced by this oral pat ...201525244614
adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality.the objective of this review was to collect available data on the following: (i) adverse effects observed in humans from the intake of plant food supplements or botanical preparations; (ii) the misidentification of poisonous plants; and (iii) interactions between plant food supplements/botanicals and conventional drugs or nutrients.201525251944
the role of phytochemicals as micronutrients in health and disease.intake of dietary phytochemicals has frequently been associated with health benefits. noninfectious diseases including cardiovascular disease (cvd), cancer and diabetes are major causes of death, whereas dementia cases are also increasing to 'epidemic' proportion. this review will focus on recent progress on mechanisms underlying the potential role of dietary phytochemicals in cvd, diabetes, cancer and dementia, with consideration of the latest clinical data.201425252018
camellia sinensis (l.) kuntze extract ameliorates chronic ethanol-induced hepatotoxicity in albino rats.the goal of this study was to investigate the hepatoprotective effects of aqueous extract of camellia sinensis or green tea extract (aqgte) in chronic ethanol-induced albino rats. all animals were divided into 4 groups in the study for a 5-week duration. 50% ethanol was given orally to the rats with two doses (5 mg/kg bw and 10 mg/kg bw) of aqgte. ethanol administration caused a significant increase in the levels of plasma and serum enzymatic markers, alanine aminotransferase (alt), aspartate am ...201425254057
molecular mechanisms by which white tea prevents oxidative stress.the flavonoid content of tea (camellia sinensis) has beneficial properties in the prevention of diseases. however, the mechanisms by which white tea can protect against oxidative stress remain unclear. to shed light on this issue, rats were given distilled water (controls), 0.15 mg/day (dose 1) or 0.45 mg/day (dose 2) of solid tea extract/kg body weight for 12 months. all the animals received an injection of adriamycin (adr; 10 mg/kg body weight), except half of the control group, which were giv ...201425255956
tooth staining potential of experimental amine fluoride/stannous fluoride mouth rinse formulations-a randomized crossover forced staining study.it was the aim to investigate experimental mouth rinses concerning their tooth and tongue staining potential using the standardized short-term forced staining model.201525257686
aluminium dynamics from soil to tea plant (camellia sinensis l.): is it enhanced by municipal solid waste compost application?application of municipal solid waste compost (mswc) in tea (camellia sinensis l.) cultivation can increase the fertility status of soils and thus enhance the plant growth. the present study attempts at application of mswc in tea (tv1 and tv23 clones) cultivation to assess the effect of different doses of mswc on growth and translocation potential of al on this plant as well as fate of al in soil, through the calculation of a risk assessment code (rac). the sequential extraction of al in mswc ame ...201525259883
bioactive metabolites from the endophytic fungus alternaria alternata.two altenuene derivatives (1-2) and one isocoumarin (3), together with six known compounds (4-9) were isolated from solid cultures of an endophytic fungus alternaria alternata, obtained from the fresh branches of camellia sinensis. chiral analysis revealed the racemic nature of 1 and 2, which were subsequently resolved into two pairs of enantiomers [(+)-1 and (-)-1, (+)-2 and (-)-2]. structures of all the isolates were identified through spectroscopic data. absolute configurations of the two pai ...201425261763
identification of novel homologous series of polyhydroxylated theasinensins and theanaphthoquinones in the sii fraction of black tea thearubigins using esi/hplc tandem mass spectrometry.thearubigins are the most abundant phenolic pigments found in black tea, produced by enzymatic oxidation of green tea flavan-3-ols in tea fermentation of until recently unknown composition. in this study electrospray ionization tandem lc-ms(n) experiments have been applied for the characterization of crude thearubigins isolated from black tea not exceeding 1000 da. the aim of this study is to confirm the oxidative cascade hypothesis of tea fermentation. the data revealed the presence of two nove ...201425263270
effect of black tea intake on blood cholesterol concentrations in individuals with mild hypercholesterolemia: a diet-controlled randomized trial.habitual intake of black tea has been associated with relatively lower serum cholesterol concentrations in observational studies. however, clinical trial results evaluating the effects of black tea on serum cholesterol have been inconsistent. several factors could explain these mixed results, in particular, uncontrolled confounding caused by lifestyle factors (eg, diet). this diet-controlled clinical trial estimates the effect of black tea flavonoid consumption on cholesterol concentrations in 5 ...201525266246
analytical strategy coupled with response surface methodology to maximize the extraction of antioxidants from ternary mixtures of green, yellow, and red teas (camellia sinensis var. sinensis).this work aimed at using a simplex-centroid design to model the effects of green, yellow, and red tea mixtures (camellia sinensis var. sinensis) on metal chelation activity, phenolic composition, antioxidant activity, and instrumental taste profile. the regression models that described the extraction of flavan-3-ols, o-diphenols, total phenolic compounds (tpc), free radical scavenging activity toward 2,2-diphenyl-1-picrylhydrazyl radical (dpph), cupric ion reducing antioxidant activity (cuprac), ...201425270398
in vitro study of color stability of polycrystalline and monocrystalline ceramic brackets.the aim of this in vitro study was to analyze color stability of monocrystalline and polycrystalline ceramic brackets after immersion in dye solutions.201525279530
review on medicinal uses, pharmacological, phytochemistry and immunomodulatory activity of plants.since ancient times, plants have been an exemplary source of medicine. researchers have discovered some important compounds from plants. the present work constitutes a review of the medicinal plants whose immunomodulant activity has been proven. we performed pubmed, embase, google scholar searches for research papers of medicinal plants having immunomodulant activity. medicinal plants used by traditional physicians or reported as having immunomodulant activity include acacia concocinna, camellia ...201725280022
assessment of bioautography and spot screening of tlc of green tea (camellia) plant extracts as antibacterial and antioxidant agents.this study was carried out as a prerequisite to evaluate the therapeutic potential of camellia varieties. the crude extracts of six different plants of green tea camellia assamica and camellia sinensis were tested against three gram-positive and four gram-negative bacteria using agar disk diffusion method at 50 mg/ml concentration. 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and diphenyl-(2,4,6-trinitrophenyl)iminoazanium free radical scavenging methods were performed to evaluate the ...201425284935
effects of extreme climate events on tea (camellia sinensis) functional quality validate indigenous farmer knowledge and sensory preferences in tropical china.climate change is impacting agro-ecosystems, crops, and farmer livelihoods in communities worldwide. while it is well understood that more frequent and intense climate events in many areas are resulting in a decline in crop yields, the impact on crop quality is less acknowledged, yet it is critical for food systems that benefit both farmers and consumers through high-quality products. this study examines tea (camellia sinensis; theaceae), the world's most widely consumed beverage after water, as ...201425286362
survey of pyrrolizidine alkaloids in teas and herbal teas on the swiss market using hplc-ms/ms.pyrrolizidine alkaloids (pas) are a large class of natural compounds amongst which the esterified 1,2-unsaturated necine base is toxic for humans and livestock. in the present study, a method was developed and validated for the screening and quantification of nine pas and one pa n-oxide in teas (camellia sinensis (l.) o. kuntze) and herbal teas (camomile, fennel, linden, mint, rooibos, verbena). samples were analysed by hplc on a rp-column, packed with sub-2 μm core-shell particles, and quantifi ...201425286874
ginseng, green tea or fibrate: valid options for nonalcoholic steatohepatitis prevention?panax ginseng, camellia sinensis and bezafibrate were compared for their lipid-lowering, antioxidant and anti-inflammatory properties as potential agents to prevent nonalcoholic fatty liver disease and its progression to nonalcoholic steatohepatitis.201425296088
content variation of catechin markers, total phenolics and caffeine in green tea dietary supplements.green tea (camellia sinensis) preparations are among the top selling products in the united states dietary supplements market. numerous manufacturers claim different levels of specific catechin markers in their products while many others use total phenolic concentration instead, or not at all. limited quality control results have been published for green tea dietary supplements over the past seven years. thus, the goal of this work was to correlate determined levels of phenolics, catechins, and ...201625299974
optimization of a dna nicking assay to evaluate oenocarpus bataua and camellia sinensis antioxidant capacity.this study was aimed at assessing the dna damage protective activity of different types of extracts (aqueous, methanolic and acetonic) using an in vitro dna nicking assay. several parameters were optimized using the puc18 plasmid, especially feso4, edta, solvent concentrations and incubation time. special attention has been paid to removing the protective and damaging effect of the solvent and feso4 respectively, as well as to identifying the relevant positive and negative controls. for each sol ...201425302614
changes of major tea polyphenols and production of four new b-ring fission metabolites of catechins from post-fermented jing-wei fu brick tea.hplc analysis of samples from four major fermentation procedures of jing-wei fu brick tea showed that the level of major tea catechins epigallocatechin gallate (egcg) and epicatechin gallate (ecg) dropped increasingly to about 1/3 in the final product. phytochemical study of the final product led to the discovery of four new b-ring fission metabolites of catechins (brfcs) fuzhuanin c-f (1-4) together with three known brfcs (5-7), six known catechins (8-13), five simple phenols (14-18), seven fla ...201525306324
[the effects of lifestyle factors on the incidence of central obesity in chinese adults aged 35-74 years].to understand the incidence of central obesity and its characteristics, and explore the effects of lifestyle factors on incidence of central obesity in chinese adults aged 35-74 years.201425312565
green tea extract and the risk of drug-induced liver injury.catechins of green tea extract (gte) have been associated with the rare risk of hepatotoxicity in a few individuals. as gte were coadministered with synthetic drugs in some hepatotoxicity cases, uncertainty emerged whether gte are a risk factor of drug-induced liver injury (dili).201425316200
de novo assembly and transcriptome characterization: novel insights into catechins biosynthesis in camellia sinensis.tea is a popular natural non-alcoholic beverage consumed worldwide due to its bioactive ingredients, particularly catechins (flavan-3-ols). catechins not only contribute to tea quality but also serve important functions in the anti-stress regulation of secondary metabolic pathways. however, the percentages of various catechins are different among tea plant [camellia sinensis (l.) o. kuntze] cultivars. this study aimed to elucidate the biosynthetic mechanism of catechins. transcriptomes from leaf ...201425316555
identification and characterization of cold-responsive micrornas in tea plant (camellia sinensis) and their targets using high-throughput sequencing and degradome analysis.micrornas (mirnas) are approximately 19 ~ 21 nucleotide noncoding rnas produced by dicer-catalyzed excision from stem-loop precursors. many plant mirnas have critical functions in development, nutrient homeostasis, abiotic stress responses, and pathogen responses via interaction with specific target mrnas. camellia sinensis is one of the most important commercial beverage crops in the world. however, mirnas associated with cold stress tolerance in c. sinensis remains unexplored. the use of high- ...201425330732
intake of dietary flavonoids and risk of epithelial ovarian cancer.the impact of different dietary flavonoid subclasses on risk of epithelial ovarian cancer is unclear, with limited previous studies that have focused on only a few compounds.201425332332
a biochemical study on ameliorative effect of green tea (camellia sinensis) extract against contrast media induced acute kidney injury.reactive oxygen species have been shown to be mediators of kidney injury and green tea polyphenols are potent-free radical scavengers.201425340167
calciphytoliths (calcium oxalate crystals) analysis for the identification of decayed tea plants (camellia sinensis l.).the history of tea is poorly known, mainly due to the questionable identification of decayed tea plants in archaeological samples. this paper attempts to test the utility of calciphytoliths (calcium oxalate crystals) for the identification of tea in archaeological samples. it provides the first survey of the macropatterns of calciphytoliths in several species of theaceae and common non-theaceae plants. crystals were extracted from 45 samples of tea, theaceae and common non-theaceae plants, and d ...201425342006
black tea increased survival of caenorhabditis elegans under stress.the present study examined the effects of black tea (camellia sinensis) extracts (bte) in caenorhabditis elegans under various abiotic stressors. results showed bte increased nematode resistance to osmosis, heat, and uv irradiation treatments. however, bte could not increase nematodes' lifespan under normal culture conditions and mncl2-induced toxicity at concentrations we used. further studies showed that bte decreased reactive oxygen species and up-regulated some antioxidant enzymes, including ...201425345740
using tea as an artificial urine in a canadian performance testing program for fission/activation products.in recent years, the national calibration reference centre for bioassay and in vivo monitoring (ncrc) at the radiation protection bureau (rpb), health canada, has been conducting investigations with black tea to develop a matrix that can be used to replace urine in each of the following performance testing programs (ptp): (1) tritium, (2) carbon-14, (3) the dual (i.e., 3h/14c), and (4) fission/activation products (f/ap). a 1% tea solution with thimerosal, which had worked successfully for tritiu ...201425353238
assessment of anti-nutritive activity of tannins in tea by-products based on in vitro rumen fermentation.nutritive values of green and black tea by-products and anti-nutritive activity of their tannins were evaluated in an in vitro rumen fermentation using various molecular weights of polyethylene glycols (peg), polyvinyl pyrrolidone (pvp) and polyvinyl polypyrrolidone as tannin-binding agents. significant improvement in gas production by addition of peg4000, 6000 and 20000 and pvp was observed only from black tea by-product, but not from green tea by-product. all tannin binding agents increased nh ...201425358316
[determination of the antimicrobial capacity of green tea (camellia sinensis) against the potentially pathogenic microorganisms escherichia coli, salmonella enterica, staphylococcus aureus, listeria monocytogenes, candida albicans and aspergillus niger].many studies can be found in scientific literature demonstrating the antimicrobial capacity of different herbs, including green tea. never-theless, many results are divergent or cannot be compared. several green tea formulations may be found in market, but there is scarce or non-information about its activity. in this work, the potential antimicrobial effect of 50 samples of dry green tea and in 10% infusion against escherichia coli, salmonella enterica, listeria monocytogenes, staphylococcus au ...201325362825
tea consumption and the incidence of cancer: a systematic review and meta-analysis of prospective observational studies.the aim of this study was to summarize the current evidence on the strength of associations between tea consumption and the incidence of cancer at different sites. we searched pubmed, embase and the cochrane library for relevant articles published before october 2013. prospective studies that reported effect estimates of cancer incidence, with 95% confidence intervals (cis), for more than two categories of tea consumption were included. we analysed 87 datasets (57 articles), which included a tot ...201525370683
comparison of the level of boron concentrations in black teas with fruit teas available on the polish market.the determination of boron by inductively coupled plasma-atomic emission spectrometry has been carried in water-soluble and acid soluble (total content) fractions of 36 samples of traditional black tea and fruit brew. the estimation of the impact of the type of tea on the concentration of boron in water-soluble and acid extracts and potential human health risk from the daily intake of boron was carried out in this study. the levels of boron differed significantly in black and fruit tea types. th ...201425379551
investigation of isomeric flavanol structures in black tea thearubigins using ultraperformance liquid chromatography coupled to hybrid quadrupole/ion mobility/time of flight mass spectrometry.ultra performance liquid chromatography (uplc) when coupled to ion mobility (ims)/orthogonal acceleration time of flight mass spectrometry is a suitable technique for analyzing complex mixtures such as the black tea thearubigins. with the aid of this advanced instrumental analysis, we were able to separate and identify different isomeric components in the complex mixture which could previously not be differentiated by a conventional high performance liquid chromatography/tandem mass spectrometry ...201425395124
risk factors for renal cell carcinoma in a japanese population.the incidence of renal cell carcinoma (rcc) is high in western and northern europe and north america, and low in asia. although the incidence of rcc in japan is lower than the rates in the other industrialized countries, there is no doubt that it is increasing. in this paper, we would like to introduce the summary of findings of jacc study, which evaluate the risk factors for rcc in a japanese population. jacc study suggests nine risk factors (i.e., smoking, obesity, low physical activity, hyper ...201425422180
the anti-obesity effect of green tea polysaccharides, polyphenols and caffeine in rats fed with a high-fat diet.beneficial effects of green tea (camellia sinensis, theaceae) extracts against obesity have been reported; however, the anti-obesity ability of the major components of green tea, polysaccharides, polyphenols and caffeine is not clear. therefore, experiments with total green tea extracts, polyphenols, polysaccharides, caffeine, and a complex of polysaccharide and polyphenol at a dose of 400 or 800 mg kg⁻¹ were conducted on high-fat diet fed rats for 6 weeks to investigate their anti-obesity effec ...201525431018
the combined use of camellia sinensis and metronomic zoledronic acid in a breast cancer-induced osteolysis mouse model.in previous studies, we demonstrated that green tea (camellia sinensis, cs) water extract had potent anti-tumor and anti-metastasis effects in the 4t1 mouse breast cancer xenograft model, and the metronomic regimen (0.0125 mg/kg twice a week for 4 weeks) of zoledronic acid (zol) was also effective in decreasing tumor burden and metastasis when compared with the conventional regimen. this study aimed to investigate the combined use of cs water extract and metronomic zol against tumor metastasis a ...201525431338
non-targeted metabolomics study for the analysis of chemical compositions in three types of tea by using gas chromatograph-mass spectrometry and liquid chromatography-mass spectrometry.tea is one of the most widely consumed beverages in the world for its benefits to daily life and health. to discover the difference and correlation of chemical compositions in the three typical types of tea, a non-targeted metabolomics method was developed. after the optimization of extraction methods, gas chromatography-time-of-flight mass spectrometry and liquid chromatography-quadrupole time-of-flight mass spectrometry were applied for metabolomics analysis, 1,812 and 2,608 features were obta ...201425434114
chemoprevention against arsenic-induced mutagenic dna breakage and apoptotic liver damage in rat via antioxidant and sod1 upregulation by green tea (camellia sinensis) which recovers broken dna resulted from arsenic-h2o2 related in vitro oxidant stress.green tea (camellia sinensis; cs) strongly reverses/prevents arsenic-induced apoptotic hepatic degeneration/micronecrosis and mutagenic dna damage in in vitro oxidant stress model and in rat as shown by comet assay and histoarchitecture (he and pas staining) results. earlier, we demonstrated a link between carcinogenesis and impaired antioxidant system-associated mutagenic dna damage in arsenic-exposed human. in this study, arsenic-induced (0.6 ppm/100 g body weight/day for 28 days) impairment o ...201425436473
simultaneous determination of 15 phenolic compounds and caffeine in teas and mate using rp-hplc/uv detection: method development and optimization of extraction process.a reversed-phase high performance liquid chromatographic coupled to ultraviolet detection (rp-hplc/uv) method was developed for simultaneous determination of 15 phenolic compounds and caffeine in teas (green tea, oolong tea, black tea and mate). furthermore, the extraction process of total phenolic contents (tpc) from teas were optimized using response surface methodology (rsm) based on a central composite design (ccd) and then applied to extraction of teas. the best conditions obtained using th ...201525442580
uncontrolled diabetes mellitus: prevalence and risk factors among people with type 2 diabetes mellitus in an urban district of karachi, pakistan.this study aimed to explore the prevalence of, and factors associated with, uncontrolled diabetes mellitus (udm) in a community setting in pakistan.201525451895
metabolite profiling of camellia sinensis by automated sequential, multidimensional gas chromatography/mass spectrometry reveals strong monsoon effects on tea constituents.seasonal variation in tea (camellia sinensis (l.) kuntze; theaceae) chemistry was investigated using automated sequential, multidimensional gas chromatography/mass spectrometry (gc-gc/ms). metabolite libraries were produced for teas harvested from the bulang mountains in yunnan, china before and after the onset of the east asian monsoon. a total of 201 spring and 196 monsoon metabolites were identified, with 169 common and 59 seasonally unique compounds. an additional 163 metabolites were detect ...201425454147
carboxymethyl- and carboxyl-catechins from ripe pu-er tea.ripe pu-er tea, a special microbial postfermented tea originated from yunnan province, china, since ancient times, is made from green pu-er tea prepared from the leaves of camellia sinensis var. assamica (theaceae). chemical investigation on thearubigin (n-buoh-soluble) fraction of the commercial ripe pu-er tea, led to the identification of four new flavan-3-ol derivatives, 8-carboxymethyl-(+)-catechin (1), 8-carboxymethyl-(+)-catechin methyl ester (2), 6-carboxymethyl-(+)-catechin (3), and 6-ca ...201425455197
comparative characterisation of green tea and black tea cream: physicochemical and phytochemical nature.tea cream is prevalent in various types of tea, yet a comparison of the mechanism of creaming in different teas remains uncertain. here, we compared physicochemical characteristics, phytochemical composition, and simulated digestive profiles of green tea and black tea cream, looking to exploit their concentration and structure based mechanisms and in vitro bioaccessibility. green tea cream particles were roughly one order of magnitude larger than those of black tea in size. moreover, creaming co ...201525466042
rapid determination of total polyphenolic content in tea samples based on caffeic acid voltammetric behaviour on a disposable graphite electrode.the present paper describes the voltammetric behaviour and the quantitative determination of caffeic acid (ca) on a disposable pencil graphite electrode (pge). the anodic peak current of ca recorded by differential pulse voltammetry (dpv) varies linearly with ca concentration in the range 1×10(-7)-3×10(-3) m. the detection and quantification limits were 8.83×10(-8) m and 2.94×10(-7) m caffeic acid, respectively. the mean recoveries of ca from turkish green, white and black teas were 98.30%, 99.5 ...201525466125
identification and evaluation of reliable reference genes for quantitative real-time pcr analysis in tea plant (camellia sinensis (l.) o. kuntze).reliable reference selection for the accurate quantification of gene expression under various experimental conditions is a crucial step in qrt-pcr normalization. to date, only a few housekeeping genes have been identified and used as reference genes in tea plant. the validity of those reference genes are not clear since their expression stabilities have not been rigorously examined. to identify more appropriate reference genes for qrt-pcr studies on tea plant, we examined the expression stabilit ...201425474086
21-o-angeloyltheasapogenol e3, a novel triterpenoid saponin from the seeds of tea plants, inhibits macrophage-mediated inflammatory responses in a nf-κb-dependent manner.21-o-angeloyltheasapogenol e3 (ats-e3) is a triterpenoid saponin recently isolated from the seeds of the tea tree camellia sinensis (l.) o. kuntze. ats-e3 has several beneficial properties including anti-inflammatory, antidiabetic, antiatherosclerotic, and anticancer effects. unlike other phenolic compounds isolated from tea plants, there are no studies reporting the pharmacological action of ats-e3. in this study, we therefore aimed to explore the cellular and molecular inhibitory activities of ...201425477714
tea (camellia sinensis (l.)): a putative anticancer agent in bladder carcinoma?the leaves of camellia sinensis (l.) are the source of tea, the second most consumed beverage worldwide. tea contains several chemical compounds such as polyphenols (mainly catechins), caffeine, theophylline, l-theanine, among many others. polyphenolic compounds are mainly responsible for its significant antioxidant properties and anticarcinogenic potential. bladder cancer is one of the most common types of cancer, and its progression and onset are thought to be controlled by dietary and lifesty ...201525482719
functional analysis of flavonoid 3',5'-hydroxylase from tea plant (camellia sinensis): critical role in the accumulation of catechins.flavonoid 3',5'-hydroxylase (f3'5'h), an important branch point enzyme in tea plant flavan-3-ol synthesis, belongs to the cyp75a subfamily and catalyzes the conversion of flavones, flavanones, dihydroflavonols and flavonols into 3',4',5'-hydroxylated derivatives. however, whether b-ring hydroxylation occurs at the level of flavanones and/or dihydroflavonols, in vivo remains unknown.201425490984
biochemical and transcriptome analyses of a novel chlorophyll-deficient chlorina tea plant cultivar.the tea plant (camellia sinensis (l.) o. kuntze) is one of the most economically important woody crops. recently, many leaf color genotypes have been developed during tea plant breeding and have become valuable materials in the processing of green tea. although the physiological characteristics of some leaf color mutants of tea plants have been partially revealed, little is known about the molecular mechanisms leading to the chlorina phenotype in tea plants.201425491435
Displaying items 2201 - 2300 of 3122