Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| effect of secondary radiation produced by 70 gev protons on dna of mammalian cells. | it is shown that the rbe of the 70 gev proton secondary radiation for the induction of single-strand break is 1.6-7.6 in chinese hamster fibroblasts and 1.04-3.8 in limphoid cells and for the lethality of chinese hamster cells 1.14-1.7. the rbe value increases with decreasing dose of the secondary radiation. on post-irradiation incubation of mammalian cells at 37 degrees c, single-strand breaks induced by the secondary radiation are repaired with the sane time course as those induced by gamma-ra ... | 1984 | 11539632 |
| subclinical hypothyroidism in flight personnel: evaluation for suitability to fly. | a group of 3,324 italian flight personnel were examined to test the usefulness of tsh assay as a screening test for subclinical hypothydroidism. forty-two individuals with low serum t4 and high free t4 had further thyroid function tests. high tsh levels were found in 14 individuals, seven of whom were started on levothyroxine. four individuals also had titers of antiperoxidase antibodies greater than 1:1,000 u/ml; three of these individuals were over age 65. tsh screening is deemed useful in the ... | 1997 | 11540646 |
| quantitative analysis of motion control in long term microgravity. | in the frame of the 179-days euromir '95 space mission, two in-flight experiments have foreseen quantitative three-dimensional human movement analysis in microgravity. for this aim, a space qualified opto-electronic motion analyser based on passive markers has been installed onboard the russian space station mir and 8 in flight sessions have been performed. techhology and method for the collection of kinematics data are described, evaluating the accuracy in three-dimensional marker localisation. ... | 1998 | 11541920 |
| hormonal adaptation to real and simulated microgravity. | the authors provide an overview of relevant results from endocrine studies in astronauts before, during, and after space flight. the hormonal systems examined are the water-electrolyte regulation, the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary gonadal axis, the growth hormone-insulin like growth factor 1-prolactin system, hormones which affect bone turnover, the hypothalamic-pituitary-thyroid axis, and the endocrine pancreas. hormones studied include renin, aldosterone, vaso ... | 1998 | 11542377 |
| the effect of alpha particles on bacteriophage t4br+. | it is generally accepted that heavy charged particles play an important part in generating the secondary flux of nuclear particles formed by the interaction of space hadrons with nuclei. it is assumed that these particles are responsible for the high biological efficiency of space hadrons in causing cellular damage by their strong interactions. to examine this assumption we investigated the effects of 5.3 mev alpha particles on bacteriophage t4. this energy provides a let value of 88.6 kev/micro ... | 1983 | 11542756 |
| [involvement of thyroid hormones in mental recovery following severe craniocerebral trauma]. | to study a role of thyroid hormones in the recovery of mental performance, 71 patients (60 males, 11 females) aged 7 to 66 years (mean age 32.7 +/- 3.5) with severe brain injury (tbi). according to the stage of mental recovery (1--none; 2--elementary acts; 3--verbal contact; 4--spatial orientation; 5--intellectual and mnestic processes and emotional and personality traits), the study was divided into 5 series. immunoradiometric assay of thyroid hormones (t3 and t4) and their free fractions (ft3 ... | 2001 | 11544736 |
| non-painful and painful surface and intramuscular electrical stimulation at the thenar and hypothenar sites: differential cerebral dynamics of early to late latency seps. | little is known about somatosensory evoked potentials (seps) from muscle stimulation compared to that from skin stimulation. the current study examined this issue in the full sep spectrum (0-440 ms). the aims of the study were to (1) establish the dynamics of early to late latency seps from intramuscular stimulation in contrast to surface stimulation, (2) compare the effect of non-painful and painful stimuli on sep latencies and amplitudes of the two methods, and (3) investigate to which extent ... | 2001 | 11545157 |
| influence of root temperature on phytoaccumulation of as, ag, cr, and sb in potato plants (solanum tuberosum l. var. spunta). | three consecutive years of field experiments were carried out to investigate the effect of root temperatures induced by the application of mulches for phytoextraction of as, ag, cr and sb using potato plants (roots, tubers, stems and leaflets). four different plastic covers were used (t1: transparent polyethylene; t2: white polyethylene; t3: white and black coextruded polyethylene; and t4: black polyethylene), taking uncovered plants as control (t0). the different treatments had a significant ef ... | 2001 | 11545361 |
| the addition of fentanyl does not alter the extent of spread of intrathecal isobaric bupivacaine in clinical practice. | fentanyl is commonly added to intrathecal local anesthetic solutions. in vitro data has shown fentanyl to render isobaric local anesthetics hypobaric, and alter the spread in artificial cerebrospinal fluid. this study examined whether the addition of fentanyl to isobaric bupivacaine with morphine leads to a clinically important alteration in the extent of spread of anesthesia. | 2001 | 11546717 |
| analysis of the postprandial lipid metabolism: use of a 3-point test. | the oral fat load tests used to study postprandial lipemia are complex and costly and time consuming. a simplified fat load test could be more convenient and more appropriate in routine clinical practice because of the number of lipid determinations required. | 2001 | 11547218 |
| [dyshormonal strain bone disease in young people]. | there were studied 453 young servicemen with dyshormonal strain bone disease in whom the hormonal status, state of carbohydrate and protein metabolism were investigated. it was established that in 92.9% of patients the growth hormone--somatotropic hormone (sth) was significantly decreased, production of thyroid hormones necessary for physiologic osteogenesis (t3 and t4) was impaired and albuminous fraction dissociation was revealed. the authors consider that in dyshormonal strain bone disease in ... | 2001 | 11547661 |
| bacteriophage t4 multiplication in a glucose-limited escherichia coli biofilm. | an escherichia coli k-12 biofilm was grown at a dilution rate of 0.028 h(-1) for 48 h in a glucose-limited chemostat coupled to a modified robbins' device to determine its susceptibility to infection by bacteriophage t4. bacteriophage t4 at a multiplicity of infection (moi) of 10 caused a log reduction in biofilm density (expressed as colony forming units (cfu) per cm2) at 90 min postinfection. after 6 h, a net decrease and equilibrium in viral titer was seen. when biofilms were exposed to t4 ph ... | 2001 | 11547890 |
| subtotal laryngectomy with cricohyoidopexy as first treatment procedure for supraglottic carcinoma: institut gustave-roussy experience (146 cases, 1974-1997). | between 1974 and 1997, 297 patients underwent a subtotal laryngectomy at the institut gustave-roussy; 146 of these patients underwent cricohyoidopexy (chp) for a supraglottic primary as their first treatment. the majority of patients were men (137) aged from 33 to 78 years (median 54 years). the tumour stage at presentation was t1 in 2, t2 in 87, t3 in 53 (preepiglottic space involvement), and t4 (minimal thyroid cartilage invasion) in 4 patients. one hundred and twenty-five patients were n0 (86 ... | 2001 | 11548904 |
| thyroid status and leptin in basedow-graves and multinodular goiter patients. | in this study it was of interest to investigate the relationship between plasma leptin levels and thyroid function in recently diagnosed 27 basedow-graves patients and 22 multinodular goiter patients brought to euthyroid state with 1 mo of propylthiouracil (ptu) treatment. a group of 15 control subjects matched for age, gender, and body mass index were also studied. in basedow-graves patients there were significantly higher t4 and t3 levels accompanied by a marked fall in plasma thyroid-stimulat ... | 2001 | 11549117 |
| distinct orders of galnac incorporation into a peptide with consecutive threonines. | mucin o-glycosylation is initiated by a transfer of n-acetyl-d-galactosamine (galnac) to ser and thr residues in polypeptides with a family of udp-galnac:polypeptide n-acetylgalactosaminyltransferases (pp-galnac-ts). in this paper, four human pp-galnac-ts (pp-galnac-t1, t2, t3, and t4) were tested for their preferential orders of galnac incorporation into fitc-ptttpittttk, a portion of the tandem repeat of human muc2. the products were separated by reverse-phase hplc and characterized by maldi-t ... | 2001 | 11549261 |
| altered expression of receptors for thyroid hormone and insulin-like growth factor-i during reconstitution after allogeneic hematopoietic stem cell transplantation. | treatment with neuroendocrine hormones has been suggested to promote reconstitution of the immune system after hematopoietic stem cell transplantation (hsct). we investigated the expression of genes encoding receptors for growth hormone (gh), insulin-like growth factor-i (igf-i) and triiodothyronine (t3), at various time points after hsct in 16 patients and 15 healthy controls. peripheral blood mononuclear cells were isolated and rna for gh receptor (ghr), igf-i receptor (igf-ir) and thyroid hor ... | 2001 | 11551027 |
| characterization of a sea bream (sparus aurata) thyroid hormone receptor-beta clone expressed during embryonic and larval development. | a clone encoding thyroid hormone receptor-beta (tr-beta) was isolated from a sea bream (sparus aurata) ovary cdna library. sea bream (sb)tr-beta is closely related to its counterparts from other vertebrates and, like them, preferentially binds t3 rather than t4. however, the putative sbtr-beta protein contains a nine-amino-acid insert that is also present in the corresponding proteins from flounder and salmon but absent in tr-betas from zebrafish and terrestrial vertebrates. semiquantitative rt- ... | 2001 | 11551120 |
| dynamic protein interactions in the bacteriophage t4 replisome. | the bacteriophage t4 dna replisome is a complex dynamic system employing a variety of proteins to orchestrate the synthesis of dna on both the leading and lagging strands. assembly of the protein complexes responsible for dna synthesis and priming requires the coordination of transient biomolecular interactions. this interplay of proteins has been dissected through the use of small molecules including fluorescent probes and crosslinkers, enabling the development of a complex dynamic structural a ... | 2001 | 11551794 |
| molecular cloning and sequence of sparus aurata skeletal myosin light chains expressed in white muscle: developmental expression and thyroid regulation. | two full-length cdna clones encoding the skeletal myosin light chain 2 (mlc2; 1452bp) and myosin light chain 3 (mlc3; 972bp) were isolated from a cdna library prepared from gilthead sea bream sparus aurata larvae. the mlc2 cdna encoded a predicted protein of 170 residues that was 79% identical to rabbit mlc2 over the entire length and 87% identical within the ca(2+)-binding region. the deduced amino acid sequence of mlc3 was 153 residues in length and was 91% and 69% identical to the zebrafish a ... | 2001 | 11551989 |
| immunohistochemical and clinicopathologic analysis of response to neoadjuvant therapy for esophageal squamous cell carcinoma. | recently, neoadjuvant chemotherapy combined with radiation (nat) has been used in the active treatment of progressive esophageal cancer (t4). however, many patients are resistant to supplemental therapy, and it is necessary to to be aware that side-effects may occur. accordingly, to minimize adverse reactions and cost, it is important to determine the indications for nat. we investigated 34 patients with t4 esophageal squamous cell carcinoma and examined the relation between the effects of nat a ... | 2001 | 11553227 |
| members of the cytophaga-flavobacterium-bacteroides phylum as intracellular bacteria of acanthamoebae: proposal of 'candidatus amoebophilus asiaticus'. | three gram-negative, rod-shaped bacteria that were found intracellularly in two environmental and one clinical acanthamoeba sp. isolates were analysed. two endocytobionts showing a parasitic behaviour were propagated successfully outside their amoebal host cells and were identified subsequently by comparative 16s rrna sequence analysis as being most closely affiliated with flavobacterium succinicans (99% 16s rrna sequence similarity) or flavobacterium johnsoniae (98% 16s rrna sequence similarity ... | 2001 | 11553234 |
| a conserved genetic module that encodes the major virion components in both the coliphage t4 and the marine cyanophage s-pm2. | sequence analysis of a 10-kb region of the genome of the marine cyanomyovirus s-pm2 reveals a homology to coliphage t4 that extends as a contiguous block from gene (g)18 to g23. the order of the s-pm2 genes in this region is similar to that of t4, but there are insertions and deletions of small orfs of unknown function. in t4, g18 codes for the tail sheath, g19, the tail tube, g20, the head portal protein, g21, the prohead core protein, g22, a scaffolding protein, and g23, the major capsid prote ... | 2001 | 11553768 |
| screening for thyroid disease of 15-17-year-old schoolchildren in an area with normal iodine intake. | the prevalence of thyroid disease in swedish schoolchildren is today insufficiently known. the aim of the study was therefore to determine the prevalence of abnormal thyroid function and thyroid autoimmunity in teen-age schoolchildren and to compare the findings with a healthy control group of 60-65-year-old inhabitants from the same community. | 2001 | 11555124 |
| evidence for glycosylation-dependent activities of polypeptide n-acetylgalactosaminyltransferases rgalnac-t2 and -t4 on mucin glycopeptides. | we present evidence that site-specific o-glycosylation by recombinant polypeptide n-acetylgalactosaminyltransferases rgalnac-t2 and -t4 is controlled by the primary sequence context, as well as by the position and structure of previously introduced o-glycans. synthetic mucin-type (glyco)peptides corresponding to sections of the tandem repeat regions of muc1, muc2, and muc4 were used as substrates for recombinant polypeptide n-acetylgalactosaminyltransferases, rgalnac-t2 and -t4. by concerted and ... | 2001 | 11555617 |
| risk factors of urethral involvement of bladder cancer after radical cystectomy with orthotopic neobladder in females. | the cystectomy and urethrectomy specimens of 20 females with invasive bladder cancer were studied for evidence of urethral involvement. the bladder showed transitional cell carcinoma in 18 cases (90%) and squamous cell carcinoma in 2 cases (10%). urethral involvement was found in 5 cases (25%). the trigone was the most common site of tumor (50%) which had 33 per cent chance of urethral involvement. bladder neck was the next common site of tumor (15%) and had 66 per cent chance of urethral involv ... | 2001 | 11556471 |
| [sagittal cobb-angle measurements in scoliosis with mri whole spine imaging]. | a newly developed mr procedure allows imaging of the whole spine in coronal and sagittal planes. we studied the use of total spine mr imaging in measuring sagittal cobb angles in scoliosis. | 2001 | 11558047 |
| interpretation of thyroid function tests. | the introduction of sensitive thyrotropin assays and free thyroid hormone measurements has simplified the interpretation of thyroid function tests. however, important pitfalls and difficult cases still exist. in this review, thyroid function test results are grouped into six different patterns. we propose that if assays for thyrotropin, free t3, and free t4 are all done, knowledge of these patterns coupled with clinical details and simple additional tests allow a diagnosis to be made in almost a ... | 2001 | 11558500 |
| galactosyldiacylglycerol, a mammalian dna polymerase alpha-specific inhibitor from a sea alga, petalonia bingbamiae. | the glycolipid galactosyldiacylglycerol (gdg), containing c16:0 and c18:1 fatty acids, was isolated from the sea alga petalonia bingbamiae as a potent inhibitor of the activities of mammalian dna polymerase alpha (pol. alpha). gdg, however, had no effect on pol. alpha from a fish or a higher plant. the inhibition of pol. alpha by gdg was dose-dependent with an ic50 value of 54 microm. the compound did not influence the activities of other replicative dna polymerases such as mammalian pol. delta, ... | 2001 | 11558581 |
| maternal dietary iodide influences turkey embryonic thyroid function. | an experiment was designed to examine a mechanism to improve embryonic survival following maternal thyroid hormone manipulation. commercial turkey breeder hens were fed diets containing supplemental iodide to mimic changes in the maternal thyroid output during an egg production cycle (32 to 48 wk of age). dietary iodide treatment depressed maternal blood thyroxine (t4) concentrations in a time-dependent manner. dietary iodide depressed maternal blood 3, 5, 3'-triiodothyronine (t3) levels across ... | 2001 | 11558913 |
| specific iga antibodies to recombinant early and nuclear antigens of epstein-barr virus in nasopharyngeal carcinoma. | nasopharyngeal carcinoma is a common cancer in taiwan. the epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma. the sera of patients with nasopharyngeal carcinoma have iga antibodies to a variety of ebv latent and replicated antigens. recently, an enzyme-linked immunosorbent assay (elisa) kit, combining both the ebv early antigen (ea) and nuclear antigen (ebna-1) became commercially available. the purpose of this study was to assess its clinical application. serum iga an ... | 2001 | 11559349 |
| a systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma. | endoscopic ultrasound (eus) may be used for preoperative staging of gastro-oesophageal carcinoma but performance values given in the literature differ. | 2001 | 11559651 |
| serum total thyroxine, total triiodothyronine, free thyroxine, and thyrotropin concentrations in dogs with nonthyroidal disease. | to determine whether nonthyroidal disease of various causes and severity is associated with abnormalities in baseline serum concentrations of total thyroxine (t4), triiodothyronine (t3), free t4, or thyrotropin (thyroid-stimulating hormone [tsh]) in dogs believed to be euthyroid. | 2001 | 11561650 |
| the role of histological investigation in prognostic evaluation of advanced gastric cancer. analysis of histological structure and molecular changes compared with invasive pattern and stage. | the relative contribution of tumour histology or molecular changes, compared with invasion pattern or stage, to prognostic assessment of gastric cancer was investigated in a series of 185 advanced (t2 to t4, stage ib to iv) cancers that had undergone intentionally curative surgery at varese general hospital. survival analysis of the histological types considered in commonly used classifications, such as lauren, kubo, the world health organization (who) and related classifications, allowed separa ... | 2001 | 11561756 |
| efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. | based on in vitro and on clinical evidence of protection against acute side effects of radiation, a prospective randomized, open study was performed to determine the efficacy of an oral proteolytic enzyme preparation in patients with head and neck cancer receiving conventional fractionated radiation therapy. | 2001 | 11561868 |
| kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive rt-pcr and indirect immunofluorescence. | we have previously shown that classical brain-like kappa opioid receptors (kor) are constitutively expressed in lymphocytic cells. including human cem x174 t-b hybrid cells, jurkat -t4 cells, human peripheral blood mononuclear cells (pbmc), human cd4+ cells and monkey pbmc (biochem. biophys. res. commun. 209 (1995) 1003). the present study further demonstrates that the kor of lymphocytes are activated in the presence of extracellular morphine or u50,488h, a kor selective agonist, and the activat ... | 2001 | 11562065 |
| two-generation reproduction study of ammonium perchlorate in drinking water in rats evaluates thyroid toxicity. | perchlorate is an inorganic ion that has recently been detected in drinking water supplies throughout the country, but little is known about its effects on reproductive function. this two-generation reproductive study examines the effects of ammonium perchlorate on the male and female reproductive systems in rats, and on the growth and development of offspring. adult sprague-dawley rats (30/sex/group) were given continuous access to ammonium perchlorate in their drinking water at doses of 0, 0.3 ... | 2001 | 11563414 |
| oral (drinking water) developmental toxicity study of ammonium perchlorate in new zealand white rabbits. | this developmental toxicity study was conducted to evaluate the embryo-fetal toxicity and teratogenic potential of ammonium perchlorate in new zealand white [hra:(nzw)spf] rabbits. pregnant rabbits were given continual access to ammonium perchlorate in drinking water at target doses of 0, 0.1, 1.0, 10.0, 30.0, and 100.0 mg/kg-day on gestation days 6 through 28. the actual consumed doses in the study were 0, 0.1, 0.9, 10.4, 30.3, and 102.3 mg/kg-day. the rabbits were sacrificed on gestation day 2 ... | 2001 | 11563415 |
| allelotyping in mycosis fungoides and sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p. | allelotyping studies have been extensively used in a wide variety of malignancies to define chromosomal regions of allelic loss and sites of putative tumor suppressor genes; however, until now this technique has not been used in cutaneous lymphoma. we have analyzed 51 samples from patients with mycosis fungoides and 15 with sézary syndrome using methods to detect loss of heterozygosity. micro satellite markers were selected on 15 chromosomal arms because of their proximity to either known tumor ... | 2001 | 11564174 |
| sympathetic innervation of mammary glands mediates suckling-induced reflex inhibition of milk yield in rats. | previous work has shown that physiologic activation of the sympathetic system may inhibit milk yield (me) in rats. thus, adrenal catecholamines (cas) are released by suckling, but it is not known whether such inhibition results also from reflex activation by the same stimulus of neural sympathetics upon the mammary gland. the present experiments were designed to determine whether suckling inhibits me induced by oxytocin (ot) in the urethane-anesthetized lactating rat, and whether such inhibition ... | 2001 | 11564449 |
| elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. | hypoxia shifts the balance of cellular energy production toward glycolysis with lactate generation as a by-product. quantitative bioluminescence imaging allows for the quantitation of lactate concentrations in individual tumors. we assessed the relationship between pretreatment tumor lactate concentrations and subsequent development of metastatic disease in patients with newly diagnosed head-and-neck cancer. | 2001 | 11567808 |
| base-of-tongue cancer: survival, function, and quality of life after external-beam irradiation and brachytherapy. | base-of-tongue cancer has traditionally been treated by surgical resection followed by radiation therapy. primary radiation therapy with brachytherapy has recently been proposed as an alternative. in a prior analysis, we found that patients with advanced tongue-base cancer treated by total glossectomy and postoperative radiation therapy can be cured while potentially maintaining good quality of life. therefore, we designed the current study to assess survival, function, and quality of life in ou ... | 2001 | 11568569 |
| the role of acute decompression and restoration of spinal alignment in the prevention of post-traumatic syringomyelia: case report and review of recent literature. | case report. | 2001 | 11568717 |
| diagnosis of canine hypothyroidism. perspectives from a testing laboratory. | the most common sample received by our endocrine testing laboratory is submitted for the diagnosis of hypothyroidism in a dog. the current tests most frequently employed in our laboratory for thyroid evaluation in dogs are total t4, free t4 by dialysis, and canine tsh measurement. each test has strengths and weaknesses and suffers from the possibility of both false positive and false negative results. this article provides a working description of each test and an approach to interpretation of r ... | 2001 | 11570134 |
| feline hyperthyroidism. diagnostics and therapeutics. | today, hyperthyroid cats are less symptomatic than those 10 or 15 years ago, and early diagnosis impacts the range and severity of the routine clinicopathological abnormalities traditionally associated with this disorder. in addition, a greater range of tests may be required to confirm a diagnosis as cats may be assessed before a serum total t4 concentration exceeds the reference range. curative treatment options may be more desirable in early cases, but renal function may be adversely affected ... | 2001 | 11570135 |
| treatment of severe double spinal cord injuries. | this is a case report describing an injury--sustained by a 25-year-old man during a car accident, and characterized by fracture dislocation of the spine at the level of c7 and t4 accompanied by pulmonary contusion. he had an incomplete spinal cord lesion at the level of c7 and a complete lesion at the level of t4 (t4 asia a). imaging of the spine showed three column fractures with ventral spinal cord compression at both levels. discussants of this case comment on the concept of acute treatment o ... | 2001 | 11571662 |
| hemithyroidectomy: long-term effects on parathyroid function--preliminary report. | early hypocalcemia after thyroid surgery has frequently been reported, whereas data regarding long-term effects on calcium homeostasis are scarce. we have previously studied patients after hemithyroidectomy with an oral calcium load test and found normal parathyroid hormone (pth) suppression. however, the 1,25-dihydroxyvitamin d concentration was decreased and the phosphate concentration increased, implying parathyroid insufficiency. we therefore proceeded to investigate pth secretion and suppre ... | 2001 | 11571952 |
| preoperative chemoradiation therapy and anal sphincter preservation with locally advanced rectal adenocarcinoma. | preoperative irradiation has been used to produce tumor regression and allow complete resection of rectal cancer with a sphincter-saving procedure. to evaluate the associated toxicity, the response in the primary tumor, and the postsurgical morbidity in a group of patients with locally advanced rectal cancer treated with preoperative chemoradiation therapy and low anterior resection, 120 patients were treated with 45 gy of preoperative radiotherapy and a bolus infusion of 5-fluorouracil 450 mg/m ... | 2001 | 11571965 |
| parotid gland carcinoma: surgical strategy based on local risk factors. | to evaluate the best surgical strategy in cases of parotid gland carcinoma, local risk factors (t, n, histology, and treatment) were analyzed in a series of 134 patients. the efficacy of the facial nerve sacrifice in case of macroscopic tumor infiltration was tested by means of survival analyses (kaplan-meier and cox algorithms). this study demonstrated that nerve preservation resulted in a better prognostic value when compared with resection only in the group of patients having a t1 or t2. in p ... | 2001 | 11572247 |
| thyroid function and aging: gender-related differences. | the effects of aging on human or animal thyroid function are still not well defined. we evaluated some aspects of thyroid function during aging using an animal model (young and old dutch-miranda rats). in old rats of both genders, serum thyroxine (t4) decreased but serum thyrotrophin (tsh) remained unaltered, suggesting a disturbance in the pituitary-thyroid feedback mechanism during aging. serum tri-iodothyronine (t3) only decreased in old males, possibly because female rats are almost twice as ... | 2001 | 11572803 |
| a study of insulin resistance in subjects with acanthosis nigricans. | to study the prevalence of insulin resistance (ir) and its sequelae in patients with acanthosis. | 2001 | 11573555 |
| infusion of amino acid enriched solution hastens recovery from neuromuscular block caused by vecuronium. | we investigated the effect of an amino acid infusion on neuromuscular block produced by vecuronium, and on rectal temperature and surface temperature over the adductor pollicis muscle. sixty adult patients undergoing general anaesthesia were randomly divided into four groups of 15 patients each: amino acid (aa)-post-tetanic count (ptc); aa-train-of-four (tof); control (c)-ptc; or c-tof group. in the aa-ptc and aa-tof groups, after a bolus of vecuronium 0.1 mg kg(-1), a continuous infusion of an ... | 2001 | 11573589 |
| rate of injection through whitacre needles affects distribution of spinal anaesthesia. | a prospective, randomized, double-blind study was performed to investigate whether altering the rate of injection of local anaesthetic through a whitacre needle had any effect on the spinal block achieved. twenty patients scheduled for elective urological surgery under spinal anaesthesia received an injection of 3 ml of 0.5% plain bupivacaine either by hand (fast) over 10 s (18 ml min(-1)) or by infusion pump (slow) over 3 min (1 ml min(-1)). all patients were in the sitting position both during ... | 2001 | 11573668 |
| treatment of inoperable stage iii and iv non-small-cell lung cancer: the 'average' radiotherapist's point of view. | stage iii non-small-cell lung cancer (nsclc) presents a major therapeutic problem for the radiation oncologist who treats patients outside of clinical trials. it is a heterogeneous disease with great variation of the clinical extent, and the optimal therapeutic decision must be based on various parameters: the most important unfavorable characteristics are represented by a low karnofsky performance status, weight loss > 5%, locally too advanced disease (e.g. t4, positive pleural effusion), inten ... | 2001 | 11574760 |
| hemodynamic and catecholamine responses to laryngoscopy and tracheal intubation in patients with complete spinal cord injuries. | endotracheal intubation in patients undergoing general anesthesia often causes hypertension and tachycardia, which may be altered when the efferent sympathetic fiber to the cardiovascular system is interrupted. the aim of the current study was to investigate the effects of different levels of spinal cord injury on the cardiovascular responses to intubation. | 2001 | 11575537 |
| genotyping of simple and compound short tandem repeat loci using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry. | the utility of electrospray ionization fourier transform ion cyclotron resonance (esi-fiicr) mass spectrometry as a new approach for genotyping short tandem repeats (strs) is demonstrated. strs are currently valued as a powerful source of genetic information with repeats that range in structure from simple to hypervariable. two tetranucleotide str loci were chosen to evaluate esi-fticr mass spectrometry as a tool for genotyping: hum-th01, a simple str with nonconsensus alleles, and vwa, a compou ... | 2001 | 11575801 |
| thyroxine and illness severity in very low-birth-weight infants. | the objective of this study was to determine the relationship between thyroxine (t4) and illness severity in a population of preterm infants. we investigated a cohort of infants with birth weights 1,500 g or less from a single level iii neonatal intensive care unit who received a minimum of one cranial sonogram to screen for intraventricular hemorrhage (ivh) and one newborn screen for t4 during a 2-year period, (n = 284). the score for neonatal acute physiology (snap) was used to measure illness ... | 2001 | 11575857 |
| severe thyrotoxicosis induced by thyroid metastasis of lung adenocarcinoma: a case report and review of the literature. | a 50-year-old woman who had undergone lung lobectomy because of lung adenocarcinoma presented with thyrotoxicosis, neck swelling, and cervical lymphadenopathy one month after the operation. the total serum triiodothyronine (t3) and thyroxine (t4) levels were markedly elevated to 514 ng/dl and 26.4 microg/dl, respectively, and serum thyrotropin (tsh) was suppressed to less than 0.005 microu/ml. although the thyroid gland had been normal before surgery, chest computed tomography (ct) scan revealed ... | 2001 | 11575859 |
| hemofiltration reduces the serum priming activity on neutrophil chemiluminescence in septic patients. | priming of the polymorphonuclear neutrophil (pmn) response has been implicated in the activation of oxidative burst and tissue injury in patients with septic shock and acute renal failure (arf). this study evaluated whether hemofiltration (hf) removes substances able to enhance the oxidative burst of pmns. | 2001 | 11576379 |
| [primary hypothyroidism in the adult older than 60 years. characteristics and follow-up after initiation of replacement treatment in hospital]. | primary hypothyroidism is common in the elderly. yet its care remains unclear. | 2001 | 11577594 |
| relations of the c-myc gene and chromosome 8 in non-small cell lung cancer: analysis by fluorescence in situ hybridization. | amplification of the c-myc gene has been reported in non-small cell lung cancer (nsclc). we investigated the c-myc gene amplification and the numerical aberration of chromosome 8 by dual color fluorescence in situ hybridization (fish) to evaluate the relation between possible genetic abnormalities, pathological factors and prognosis. | 2001 | 11578259 |
| bone mineral density in pre-and post-menopausal women with affective disorder treated with long-term l-thyroxine augmentation. | augmentation with tsh-suppressive l-thyroxine (t4) has been shown to improve the course of illness in otherwise refractory affective disorders. this collaborative study investigates whether t4 augmentation for a minimum of 12 months decreases bone mineral density (bmd) in 26 pre- and post-menopausal women with affective disorder. | 2001 | 11578671 |
| knowledge-based potential defined for a rotamer library to design protein sequences. | a knowledge-based potential for a rotamer library was developed to design protein sequences. protein side-chain conformations are represented by 56 templates. each of their fitness to a given structural site-environment is evaluated by a combined function of the three knowledge-based terms, i.e. two-body side-chain packing, one-body hydration and local conformation. the number of matches between the native sequence and the structural site-environment in the database and that of the virtually set ... | 2001 | 11579224 |
| comparison of bacteriophage t4 uvsx and human rad51 filaments suggests that reca-like polymers may have evolved independently. | the uvsx protein from bacteriophage t4 is a member of the reca/rad51/rada family of recombinases active in homologous genetic recombination. like reca, rad51 and rada, uvsx forms helical filaments on dna. we have used electron microscopy and a novel method for image analysis of helical filaments to show that uvsx-dna filaments exist in two different conformations: an adp state and an atp state. as with reca protein, these two states have a large difference in pitch. remarkably, even though uvsx ... | 2001 | 11580245 |
| longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening. | to evaluate longitudinal growth, pubertal development and final height in patients with congenital hypothyroidism (ch) detected by a neonatal screening programme, and to identify factors potentially affecting growth outcome. | 2001 | 11580992 |
| haemodynamic changes following treatment of subclinical and overt hyperthyroidism. | hyperthyroidism has profound effects on the cardiovascular system, including reduced systemic vascular resistance (svr) due to relaxation of vascular smooth muscle cells, enhanced heart rate (hr) and cardiac output (co) due to an increase in cardiac diastolic relaxation, contractility and heart rate. subclinical hyperthyroidism is characterised by reduced serum tsh levels despite free thyroxine (t4) and tri-iodothyronine (t3) estimates within the reference range, in subjects with no obvious symp ... | 2001 | 11580994 |
| prevalence and characteristics of postpartum thyroid dysfunction in tehran. | to determine the prevalence of postpartum thyroiditis (ppt), one of the autoimmune disorders of the thyroid which usually occurs in women in the first year after parturition. ppt presents with periods of transient thyrotoxicosis and hypothyroidism, in many cases resulting in permanent hypothyroidism. | 2001 | 11580995 |
| benefit of surgery after chemoradiotherapy in stage iiib (t4 and/or n3) non-small cell lung cancer. | the purpose of this study was to evaluate postchemoradiotherapy surgery in stage iiib non-small cell lung cancer. | 2001 | 11581616 |
| [chromosomal location and molecular marker of resistance gene to puccinia striiformis west. in leymus mollis trin. hara]. | the hybrid wheat line, 93784 is a stable line selected from progenies of leymus molli trin. hara x common wheat, which shows a very high level of resistance to yellow rust. the results of gish using genomic dna of leymus mollis as probe indicated that the 93784 was a wheat-leymus mollis small segment translocation line, and the translocated alien chromosome fragment were located on a pair of short arm terminals of what chromosomes. using this translocation line, we established f2 segregation pop ... | 2001 | 11582747 |
| undifferentiated nasopharyngeal carcinoma in children and adolescents: comparison between staging systems. | new criteria for classifying nasopharyngeal carcinoma were defined in the 5th edition of the american joint committee on cancer (ajcc) staging manual. we investigated the clinical implications of the new system by comparing it with the 4th edition in a cohort of pediatric undifferentiated nasopharyngeal carcinoma (unpc). | 2001 | 11583200 |
| experiences in thoracoscopic sympathectomy for axillary hyperhidrosis and osmidrosis: focusing on the extent of sympathectomy. | a more selective sympathectomy can improve the outcome of axillary hyperhidrosis and osmidrosis and minimize the potential sequelae. | 2001 | 11585501 |
| loss of heterozygosity and microsatellite instability at chromosomal sites 1q and 10q in morphologically distinct regions of late stage prostate lesions. | we investigated the incidence of loss of heterozygosity (loh) and microsatellite instability in sporadic prostate cancer and surrounding tissue at loci encompassing the hpc1 and pten genes. | 2001 | 11586263 |
| bacteriophage t4 regb endoribonuclease. | 2001 | 11586918 | |
| autoimmune hypothyroidism coexisting with a pituitary adenoma secreting thyroid-stimulating hormone, prolactin and alpha-subunit. | a 44-year-old woman presented to her gp with excessive tiredness. she had positive thyroid microsomal and thyroglobulin autoantibodies and was found to have an elevated serum thyroid-stimulating hormone (tsh) concentration of 8.37 (normal = 0.15-3.5)mu/l and a low normal total thyroxine (t4) of 86 (reference range 60-145)nmol/l. she was rendered symptom free on a dose of 150 microg of thyroxine per day. however, her tsh failed to return to normal, and following a further increase in her thyroxin ... | 2001 | 11587139 |
| [post-traumatic endocrine deficits : analysis of a series of 93 severe traumatic brain injuries]. | the aim of the study is to measure the incidence in severe traumatic brain injury of endocrine deficits with special consideration for hypotestosteronemia in male patients. | 2001 | 11587651 |
| n-acetylgalactosamine incorporation into a peptide containing consecutive threonine residues by udp-n-acetyl-d-galactosaminide:polypeptide n-acetylgalactosaminyltransferases. | a limited number of glycosylation products were generated in a cell-free system from a portion of the muc2 tandem repeat, ptttpittttk, when microsome fractions of human colon carcinoma ls174t cells were used as the source of udp-n-acetyl-d-galactosaminide:polypeptide n-acetylgalactosaminyltransferases (pp-galnac-t) in our previous work. the structures of all products suggested that there were only two biosynthetic pathways in the galnac incorporation into this peptide. in the present report, the ... | 2001 | 11588158 |
| effects of normothermia versus hypothermia on extravascular lung water and serum cytokines during cardiopulmonary bypass: a randomized, controlled trial. | to evaluate the influence of perfusion temperature on the systemic effects of cardiopulmonary bypass (cpb), including extravascular lung water index (evlwi), and serum cytokines. | 2001 | 11588449 |
| specific detection of cyclobutane pyrimidine dimers in phytoplankton dna by a non-radioactive assay based on t4-endonuclease v digestion. | the effect of artificial and natural uv irradiation on dna in marine phytoplankton isochrysis galbana monoculture was investigated. the presence of cyclobutane pyrimidine dimers (cpds) in unlabelled i. galbana dna was detected by a non-radiometric alkaline filter elution assay after t4-endonuclease v digestion. the quantity of cpds was estimated by alkaline agarose gel electrophoresis. precise determination of the amount of dna in the presence of i. galbana pigments was achieved by oxazole yello ... | 2001 | 11589394 |
| epidural analgesia attenuates the systemic stress response to upper abdominal surgery: a randomized trial. | the effects of combined general anaesthesia and epidural analgesia in various endocrine and metabolic parameters were studied before, during, at the end, and 72 h after upper abdominal surgery, in an effort to further elucidate the role of epidural analgesia in the endocrine and metabolic response. 50 patients were randomly assigned into groups a and b, which received general anaesthesia alone and combined general anaesthesia and epidural analgesia, respectively. the effects of surgical stress i ... | 2000 | 11589607 |
| the effect of low temperature and fasting during the winter on metabolic stores and endocrine physiology (insulin, insulin-like growth factor-i, and thyroxine) of coho salmon, oncorhynchus kisutch. | the objective of this study was to examine the effect of winter feeding and fasting at both high (10 degrees ) and low (2.5 degrees ) temperatures on growth, metabolic stores, and endocrinology of coho salmon. treatments were as follows: warm-fed, warm-not fed, cold-fed, and cold-not fed during the winter (january-february). the following parameters were measured: length, weight, whole body lipid, liver glycogen, hepatosomatic index, and plasma levels of insulin, insulin-like growth factor-i (ig ... | 2001 | 11589631 |
| tsh-receptor antibody measurement for differentiation of hyperthyroidism into graves' disease and multinodular toxic goitre: a comparison of two competitive binding assays. | graves' disease is characterized by stimulating autoantibodies to the tsh-receptor (trab). the aim of this study was to compare the performance of a new trab assay based on competitive binding to recombinant human tsh-receptors (h-trab) with an assay employing purified porcine tsh-receptors (p-trab). furthermore, to evaluate the applicability of the h-trab assay to discriminate between patients with hyperthyroidism due to graves' disease (gd) and multinodular toxic goitre (mntg). | 2001 | 11589682 |
| prevalence of gestational thyrotoxicosis in asian women evaluated in the 8th to 14th weeks of pregnancy: correlations with total and free beta human chorionic gonadotrophin. | the prevalence of gestational transient thyrotoxicosis (gtt) in europeans evaluated during the 8th to 14th weeks of pregnancy is 2-3%. however, there is evidence that gtt may be more common in some asian populations. the aims of this study were to evaluate the prevalence of thyroid hormone abnormalities in asian women in their 8th to 14th weeks of pregnancy using highly sensitive free t4 and tsh assays and to correlate these with total and free beta-hcg levels. | 2001 | 11589683 |
| comparison of immune parameters of sheep with naturally high or low plasma concentrations of melatonin. | studies in rodents and humans have suggested that the pineal gland and its secretory product melatonin play an important role in the modulation of the immune system. in this study, we tested the hypothesis of a difference in immune parameters between ewes with naturally high vs. low circulating melatonin. thus, two comparable groups of 10 ile-de-france sheep were selected from a large flock, for their naturally high and low plasma concentrations of melatonin. the mean plasma melatonin concentrat ... | 2001 | 11589760 |
| alterations in an ire1-rna complex in the mammalian unfolded protein response. | ire1 proteins mediate cellular responses to accumulation of malfolded proteins in the endoplasmic reticulum in the yeast and mammalian unfolded protein responses. a sensitive in vivo u.v. crosslinking assay showed that ire1 proteins are intimately associated with rna in mammalian cells. the ire1-associated rna fragments recovered by this assay were different in stressed and unstressed cells. the amount of rna associated with ire1 that could be revealed by end-labeling with t4 kinase was greater ... | 2001 | 11590247 |
| neonatal goiter caused by expectorant usage. | a female newborn was admitted with the symptoms of mild respiratory distress, protruding tongue, hypotonicity, cutis marmorata, sclerema, myxedema, abdominal distension, and feeding problems on the first day of life. she had a huge neck mass, a large anterior and posterior fontanel, and hoarse cry. she had no umbilical hernia or jaundice. a history of maternal potassium iodine (expectorant) usage without doctor's advice was obtained; the mother had not attended a clinic throughout the pregnancy. ... | 2001 | 11592576 |
| factors involved in the neuronal death during postischemic reperfusion: experimental study in rabbits. | to explore the main pathogenic factors in the development of neuronal death during normothermic reperfusion in rabbits. | 1999 | 11593584 |
| postmastectomy radiotherapy in women with breast cancer metastatic to one to three axillary lymph nodes. | the influence of postmastectomy radiotherapy on survival has long been debated. early randomized trials established a clear role for adjuvant postmastectomy chest wall radiotherapy (pmcwrt) in reducing locoregional recurrence (lrr), and pmcwrt became standard therapy for patients at high risk of lrr: those with t3 or t4 tumors and four or more involved lymph nodes. however, without effective systemic therapy, distant metastases limited any effect of improved local control on overall outcome, and ... | 2001 | 11595118 |
| prevalence of endocrine dysfunction in hiv-infected men. | endocrine dysfunction is a common problem in patients with human immunodeficiency virus infection (hiv). we therefore evaluated the endocrine function in 31 male homosexual hiv-1-infected men: mean age 37 +/- 7.2 years (range 24-52). | 2000 | 11595820 |
| p300 asymmetry in schizophrenia: a meta-analysis. | p300 event-related brain potential (erp) amplitude is smaller in patients with schizophrenia compared to unaffected controls, but whether left temporal component amplitude is also smaller is debated. the present study employed meta-analytical methods to quantitatively assess previous p300 schizophrenia asymmetry findings. all p300 articles on schizophrenia using an auditory oddball paradigm published before january 2000 were obtained by comprehensive literature searches and cross-referencing for ... | 2001 | 11600190 |
| analysis of intracellular didanosine triphosphate at sub-ppb level using lc-ms/ms. | an analytical procedure has been developed for the analysis of intracellular didanosine triphosphate (ddatp). an electrospray ionization tandem mass spectrometer (esi-ms) was interfaced to liquid chromatography (lc) using a mobile phase ch3oh/h2o (25/75) containing 1% formic acid for the analysis of the 5'-triphosphate metabolite of the antiviral didanosine. in this procedure, ddatp was extracted from cem-t4 cells, isolated using an exchange anion solid phase extraction procedure, enzymatically ... | 2001 | 11600293 |
| what is your neurologic diagnosis? osteochondroma of the dorsal process of t4. | 2001 | 11601785 | |
| stepwise deletion of the hiv type 1 glycoprotein 41 n terminus leads to an increasing export of microvesicles containing uncleaved env glycoprotein. | deletion of two or more amino acid residues from the n terminus of hiv-1 gp41 leads to an increasing loss of cleavability of the envelope (env) precursor on introduction of an env-expressing vector into hela-t4+ cells. in protein analysis, this is paralleled by the appearance of a second form of uncleaved env precursor that is terminally sialylated. cell-derived microvesicles that preferentially incorporate this form of env precursor were found in the culture medium. the same applies to a mutant ... | 2001 | 11602045 |
| cloning, sequence and structure of a gene encoding an antifungal glucan 1,3-beta-glucosidase from trichoderma atroviride (t. harzianum). | a gene (gluc78) encoding an antifungal glucan 1,3-beta-glucosidase was cloned from strain p1 of the biocontrol fungus trichoderma atroviride (formerly t. harzianum). a putative regulatory sequence upstream from the coding region was cloned using single-strand extension from a primer in the known portion of the gene, circularized with t4 ligase, and then reamplified with pcr to generate double-stranded dna. the entire genomic dna sequence consisted of 3440 bp, with 559 and 579 bp, respectively, i ... | 2001 | 11602357 |
| structural basis for helper t-cell and antibody epitope immunodominance in bacteriophage t4 hsp10. role of disordered loops. | antigen three-dimensional structure potentially limits the access of endoproteolytic processing enzymes to cleavage sites and of class ii major histocompatibility antigen-presenting proteins to helper t-cell epitopes. helper t-cell epitopes in bacteriophage t4 hsp10 have been mapped by restimulation of splenocytes from cba/j and c57bl/6j mice immunized in conjunction with mutant (r192g) heat-labile enterotoxin from escherichia coli. promiscuously immunogenic sequences were associated with unstab ... | 2002 | 11602571 |
| the ul6 gene product forms the portal for entry of dna into the herpes simplex virus capsid. | during replication of herpes simplex virus type 1 (hsv-1), viral dna is synthesized in the infected cell nucleus, where dna-free capsids are also assembled. genome-length dna molecules are then cut out of a larger, multigenome concatemer and packaged into capsids. here we report the results of experiments carried out to test the idea that the hsv-1 ul6 gene product (pul6) forms the portal through which viral dna passes as it enters the capsid. since dna must enter at a unique site, immunoelectro ... | 2001 | 11602732 |
| the minimum effective dose of 0.5% hyperbaric spinal bupivacaine for cesarean section. | the aim of this prospective, blind study was to determine the minimum effective dose of hyperbaric bupivacaine required for cesarean section. | 2001 | 11602876 |
| effects of tripcholorolide on inflammatory reaction of mouse alveolar macrophages in vitro. | to observe the effects of tripcholorolide (t4) on inflammatory reaction of mouse alveolar macrophages. | 2000 | 11603300 |
| percutaneous ethanol injection of autonomous thyroid nodules with a volume larger than 40 ml: three years of follow-up. | autonomous thyroid nodules are conventionally treated by surgery or radioiodine. percutaneous ethanol injection is a recognized alternative approach. an assessment of the long-term success and safety was conducted. | 2001 | 11603892 |
| predictive value of altered p27kip1 and p21waf/cip1 protein expression for the clinical prognosis of patients with localized prostate cancer. | the p21waf/cip and the p27kip1 genes have been identified as inductors of cell cycle arrest at the g1-checkpoint. alterations of both genes have been suggested to be involved in the development of a variety of human malignancies due to a loss of critical antiproliferative mechanisms. to evaluate the prognostic importance of these alterations for patients with clinically localized prostate cancer, in 86 specimens (t1-t4) from 86 patients undergoing radical prostatectomy at the department of urolo ... | 2001 | 11605074 |
| [not available]. | the euthanasia action in nazi germany during 1940/41 ("aktion t4") belongs to the most horrible chapters in history of medicine. the article describes the life of horst schumann, who was involved in the murder of more than 15 000 people and after that did cruel sterilization experiments in auschwitz. it will be depicted the personal characteristics to show, why he was susceptible to this development. the critical look at these events shall warn us not to push away mental patients and mentally ha ... | 1998 | 11619921 |
| a tale of two hsv-1 helicases: roles of phage and animal virus helicases in dna replication and recombination. | helicases play essential roles in many important biological processes such as dna replication, repair, recombination, transcription, splicing, and translation. many bacteriophages and plant and animal viruses encode one or more helicases, and these enzymes have been shown to play many roles in their respective viral life cycles. in this review we concentrate primarily on the roles of helicases in dna replication and recombination with special emphasis on the bacteriophages t4, t7, and a as model ... | 2001 | 11642367 |