Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| pcr-based identification of klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma. | rhinoscleroma is a chronic granulomatous infection of the upper airways caused by the bacterium klebsiella pneumoniae subsp. rhinoscleromatis. the disease is endemic in tropical and subtropical areas, but its diagnosis remains difficult. as a consequence, and despite available antibiotherapy, some patients evolve advanced stages that can lead to disfiguration, severe respiratory impairment and death by anoxia. because identification of the etiologic agent is crucial for the definitive diagnosis ... | 2011 | 21629720 |
| comparative evaluation of boronic acid combined-disk tests for the detection of kpc carbapenemase-producing enterobacteriaceae clinical isolates. | the accurate phenotypic detection of kpc-producing enterobacteriaceae is an increasing necessity worldwide. we evaluated the performance of boronic acid combined-disk tests using as substrate impenem or meropenem and as inhibitor of kpc production 300 μg aminophenylboronic acid (apba), 600 μg apba or 400 μg phenylboronic acid (pba). tests were considered positive when an increase in the growth-inhibitory zone around carbapenem disk with kpc inhibitor was 5 mm or greater of the growth-inhibitory ... | 2011 | 21632901 |
| bacteriology of deep neck abscesses: a retrospective review of 96 consecutive cases. | introduction: this study aimed to review the microbiology of deep neck abscesses and identify the factors that influence their occurrence. methods: a retrospective chart review was done of patients diagnosed with deep neck abscesses at the department of otorhinolaryngology, tan tock seng hospital, singapore between 2004 and 2009. the data of 131 deep neck abscess patients were reviewed, and those with positive pus culture were included in the study. logistic regression was applied to analyse and ... | 2011 | 21633769 |
| [effect of heavy metal ions on triphenyltin enzymatic degradation]. | the influence of different metal ions and different forms of addition on triphenyltin enzymatic degradation was investigated under conditions using enzyme obtained from klebsiella pneumoniae. the objective of this study is to illuminate the mechanism of enzymatic degradation of triphenyltin (tpht). the results demonstrated that the strain was able to tolerate k+, mg2+, cu2+, ca2+ and fe3+ at high concentrations. high concentrations of zn2+ and fe2+ had some toxic effects on the strain, thus affe ... | 2011 | 21634178 |
| carbapenemase-producing klebsiella pneumoniae: (when) might we still consider treating with carbapenems? | clin microbiol infect 2011; 00: 000-000 abstract: infections caused by carbapenemase-producing klebsiella pneumoniae (cpkp) are increasing in frequency worldwide. cpkp isolates exhibit extensive drug resistance phenotypes, complicate therapy, and limit treatment options. although cpkp isolates are often highly resistant to carbapenems, a proportion of these have relatively low mics for carbapenems, raising the question of whether this class of agents has any therapeutic potential against cpkp in ... | 2011 | 21635663 |
| studies on interaction of colloidal silver nanoparticles (snps) with five different bacterial species. | silver nanoparticles (snps) are being increasingly used in many consumer products like textile fabrics, cosmetics, washing machines, food and drug products owing to its excellent antimicrobial properties. here we have studied the adsorption and toxicity of snps on bacterial species such as pseudomonas aeruginosa, micrococcus luteus, bacillus subtilis, bacillus barbaricus and klebsiella pneumoniae. the influence of zeta potential on the adsorption of snps on bacterial cell surface was investigate ... | 2011 | 21640562 |
| klebsiella pneumoniae producing kpc carbapenemase in a district general hospital in the uk. | we report two patients with multidrug-resistant kpc-carbapenemase-producing klebsiella pneumoniae urinary tract infections. a bla(kpc-2) gene was detected in both of the isolates by polymerase chain reaction and sequencing. the isolates had identical pulsed-field gel electrophoresis patterns and belonged to sequence type st11. the index patient probably acquired the kpc-producing strain while in hospital in curaçao, with subsequent nosocomial transmission to the second patient occurring in our h ... | 2011 | 21641083 |
| assessing the effect of oxygen and microbial inhibitors to optimize ferricyanide-mediated bod assay. | methods for short-term bod analysis (bod(st)) based on ferricyanide mediator reduction have succeeded in overcoming some problems associated with the standard bod test analysis (bod(5)) such as long-term incubations (5 days), the need to dilute samples and low reproducibility. here we present a bioassay where a klebsiella pneumoniae environmental strain successfully reduces ferricyanide without de-aeration of the samples with linear bod(5) ranges between 30 and 500mgl(-1) or 30 and 200mgl(-1), u ... | 2011 | 21645725 |
| biofilm formation as a function of adhesin, growth medium, substratum and strain type. | biofilm formation is involved in the majority of bacterial infections. comparing six escherichia coli and klebsiella pneumoniae isolates revealed significant differences in biofilm formation depending on the growth medium. fimbriae are known to be involved in biofilm formation, and type 1, f1c and p fimbriae were seen to influence biofilm formation significantly different depending on strain background, growth media and aeration as well as surface material. altogether, this report clearly demons ... | 2011 | 21646046 |
| expression of a clostridium perfringens type iv pilin by neisseria gonorrhoeae mediates adherence to muscle cells. | clostridium perfringens is an anaerobic, gram-positive bacterium that causes a range of diseases in humans, including lethal gas gangrene. we have recently shown that strains of c. perfringens move across the surface of agar plates using a unique type iv pili (tfp)-mediated social motility that had not been previously described. based on sequence homology to pilins in gram-negative bacteria, c. perfringens appears to have two pilin subunits, pila1 and pila2. structural prediction analysis indica ... | 2011 | 21646450 |
| asymptomatic bacteriuria and antibacterial susceptibility patterns in an obstetric population. | introduction. asymptomatic bacteriuria (asb), occurring in 2-11% of pregnancies, is a major predisposition to the development of pyelonephritis, which is associated with obstetrical complications, such as preterm labor and low birth weight infants. the aim of this study was to determine the prevalence of asb, the antibacterial susceptibilities of the isolated microorganisms and the associated risk factors in an outpatient clinical setting in zekai tahir burak women's health education and researc ... | 2011 | 21647231 |
| synergistic antibacterial effects of polyphenolic compounds from olive mill wastewater. | polyphenols or phenolic compounds are groups of secondary metabolites widely distributed in plants and found in olive mill wastewater (omw). phenolic compounds as well as omw extracts were evaluated in vitro for their antimicrobial activity against gram-positive (streptococcus pyogenes and staphylococcus aureus) and gram-negative bacteria (escherichia coli and klebsiella pneumoniae). most of the tested phenols were not effective against the four bacterial strains when tested as single compounds ... | 2011 | 21647315 |
| the impact of a nationwide antibiotic restriction program on antibiotic usage and resistance against nosocomial pathogens in turkey. | purpose: antimicrobial resistance among microorganisms is a global concern. in 2003, a nationwide antibiotic restriction program (narp) was released in turkey. in this study we evaluated the effect of narp on antibiotic consumption, antimicrobial resistance, and cost.materials and methods: the data obtained from all of the four university hospitals, and one referral tertiary-care educational state hospital in ankara. antimicrobial resistance profiles of 14,233 selected microorganisms all grown i ... | 2011 | 21647326 |
| synthesis of 4-hydroxycoumarin heteroarylhybrids as potential antimicrobial agents. | a new series of 4-hydroxycoumarin derivatives 3a-d was synthesized by the reaction of 3-bromo-4-hydroxy coumarin 1 with various heteroaldehydes 2a-d in good yields. the synthesized compounds were characterized on the basis of their elemental and spectral (ir, (1) h-nmr and mass spectrometry) analysis. all target compounds were evaluated for their in-vitro antimicrobial activity against streptococcus pyogenes, methicillin-resistant staphylococcus aureus, pseudomonas aeruginosa, klebsiella pneumon ... | 2011 | 21647940 |
| community acquired pneumonia in port harcourt rivers state of nigeria. | community acquired pneumonia (cap) is a major cause of death world wide. knowledge of the likely pathogens and their sensitivity/resistance pattern can help in the choice of antibiotic therapy and improve outcome. | 2008 | 21648126 |
| [comparison of 2,3-butanediol production by several strains and optimization of the fermentation medium]. | five klebsiella pneumonia strains (including two strains whose genes for lactic acid were knocked out) were used to produce 2,3-butanediol, in which k. pneumonia hr521 ldh (gene for lactic acid was knocked out) was the best for the production, and then the fermentation medium was optimized by orthogonal design. the optimum compositions were as follows: glucose 90 g/l, (nh4)2hpo4 3 g/l, clsp 6 g/l, sodium acetate 5 g/l, kcl 0.4 g/l, mgso4 0.1 g/l, feso4 x 7h2o 0.02 g/l, mnso4 0.01 g/l. under the ... | 2011 | 21650032 |
| microstructured cystine dendrites-based impedimetric sensor for nucleic acid detection. | we report results of the studies relating to the fabrication and characterization of novel biosensing electrode by covalent immobilization of dna onto microstructural cystine (cys) prepared by acoustic cavitation method. the tem investigations of these structures reveal transformation of microstructured cys from nanorods to dendritic structure under optimum conditions. the cys dendrites (dencys) have been investigated by xrd, ft-ir, and sem studies. these biosensing electrodes have been fabricat ... | 2011 | 21650182 |
| country-to-country transfer of patients and the risk of multi-resistant bacterial infection. | management of patients with a history of healthcare contact in multiple countries is now a reality for many clinicians. leisure tourism, the burgeoning industry of medical tourism, military conflict, natural disasters, and changing patterns of human migration may all contribute to this emerging epidemiological trend. such individuals may be both vectors and victims of healthcare-associated infection with multiresistant bacteria. current literature describes intercountry transfer of multiresistan ... | 2011 | 21653302 |
| carbapenem-resistant enterobacteriaceae: epidemiology and prevention. | over the past 10 years, dissemination of klebsiella pneumoniae carbapenemase (kpc) has led to an increase in the prevalence of carbapenem-resistant enterobacteriaceae (cre) in the united states. infections caused by cre have limited treatment options and have been associated with high mortality rates. in the previous year, other carbapenemase subtypes, including new delhi metallo-β-lactamase, have been identified among enterobacteriaceae in the united states. like kpc, these enzymes are frequent ... | 2011 | 21653305 |
| multilocus sequence typing of incn plasmids. | objectives incompatibility group n (incn) plasmids have been associated with the dissemination of antimicrobial resistance and are a major vehicle for the spread of bla(vim-1) in humans and bla(ctx-m-1) in animals. a plasmid multilocus sequence typing (pmlst) scheme was developed for rapid categorization of incn plasmids. methods twelve fully sequenced incn plasmids available at genbank were analysed in silico for selecting the loci for the incn-specific pmlst. a total of 58 plasmids originating ... | 2011 | 21653604 |
| early detection of colonization by vim-1-producing klebsiella pneumoniae and ndm-1-producing escherichia coli in two children returning to france. | rapid identification of metallo-β-lactamase-producing gram-negative species is crucial for the timely implementation of infection control measures. we describe two pediatric cases in which colonization by vim-1- and new delhi metallo-beta-lactamase 1-producing enterobacteriaceae was rapidly detected by phenotypic and genotypic methods. phenotypic methods can be useful for routine detection of carbapenemase production. | 2011 | 21653781 |
| an outbreak of ctx-m-15-producing klebsiella pneumoniae isolates in an intensive care unit of a teaching hospital in kuwait. | this study reports an outbreak of klebsiella pneumoniae infections in 14 patients during a 2-month period (august-september, 2008) in the intensive care unit (icu) of a teaching hospital in kuwait. | 2011 | 21654106 |
| correlation of tem, shv and ctx-m extended-spectrum beta lactamases among enterobacteriaceae with their in vitro antimicrobial susceptibility. | the present study was carried out to characterize the esbl types and evaluated their in vitro activity against a collection of gram negative bacteria (gnb) from a multicentric indian surveillance study. | 2011 | 21654112 |
| endotipsitis: a diagnostic challenge. | 2011 | 21654138 | |
| hemoperfusion treatment in a septic shock patient with autosomal dominant polycystic kidney disease and increased hmgb1 protein levels. | this case report describes polymyxin b-immobilized fiber (pmx-f) treatment of septic shock caused by pyelonephritis in a 68-year-old woman with autosomal dominant polycystic kidney disease. she was admitted for severe lower left abdominal pain, high fever (40°c) and gross hematuria. her endotoxin and high-mobility group box-1 protein (hmgb1) levels were extremely elevated. her blood pressure was 68/36 mm hg. urinalysis revealed innumerable white blood cells (wbcs). blood and urine cultures were ... | 2011 | 21654166 |
| effect of antibiotic diversity on ventilator-associated pneumonia caused by eskape organisms. | the aim of this study was to test in the clinic whether antimicrobial diversity affects resistance of enterococcus faecium, staphylococcus aureus, klebsiella species, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter species (eskape) pathogens in ventilator-associated pneumonia (vap). | 2011 | 21659436 |
| diversity and phylogeny of bacteria on zimbabwe tobacco leaves estimated by 16s rrna sequence analysis. | microorganisms play important roles in the tobacco aging process. however, microbial communities on flue-cured tobacco leaves (fctl) remain largely unknown. in this study, the total microbial genomic dna of unaged and aging fctl from zimbabwe were isolated using a culture-independent method, and the bacterial communities were investigated through analyzing two 16s rrna gene libraries. eighty-four and 65 operational taxonomic units were obtained from the libraries of the unaged and aging fctl, re ... | 2011 | 21660545 |
| addition of genes for cellobiase and pectinolytic activity in escherichia coli for fuel ethanol production from pectin-rich lignocellulosic biomass. | ethanologenic escherichia coli strain ko11 was sequentially engineered to contain the klebsiella oxytoca cellobiose phosphotransferase genes (casab) as well as a pectate lyase (pele) from erwinia chrysanthemi, yielding strains ly40a (casab) and jp07 (casab pele), respectively. to obtain an effective secretion of pele, the sec-dependent pathway out genes from e. chrysanthemi were provided on a cosmid to strain jp07 to construct strain jp07c. finally, oligogalacturonide lyase (ogl) from e. chrysan ... | 2011 | 21666025 |
| institutional control measures to curtail the epidemic spread of carbapenem-resistant klebsiella pneumoniae: a 4-year perspective. | to describe the implementation of an institution-wide, multiple-step intervention to curtail the epidemic spread of carbapenem-resistant klebsiella pneumoniae (crkp). | 2011 | 21666398 |
| [bacteraemia due to escherichia coli producing extended-spectrum beta-lactamases (esbl): clinical relevance and today's insights]. | antibiotic resistance is an old problem with new face as the rate of infections due to multidrug resistant bacteria is higher everyday and the number of new antibiotics to overwhelm the problem is becoming smaller. e. coli is the most frequent agent causing nosocomial or community-acquired bacteraemia being in our country 10% of them extended-spectrum beta-lactamases (esbl) producing e. coli isolates. nowadays the number of community- acquired or health-related infections caused by these esbl pr ... | 2011 | 21666996 |
| microbial pathogens causative of neonatal sepsis in arabic countries. | neonatal sepsis is a major cause of morbidity and mortality worldwide. we analyzed the spectrum of pathogens causing neonatal sepsis in various arabic countries. | 2011 | 21668322 |
| outbreak of kpc-3-producing, and colistin-resistant, klebsiella pneumoniae infections in two sicilian hospitals. | clin microbiol infect 2011; 17: 1444-1447 abstract: we report the first outbreak caused by colistin-resistant klebsiella pneumoniae producing kpc-3 carbapenamase in two italian hospitals. this spread occurred in 1-ámonth, and was caused by eight colistin-resistant and carbapenem-resistant klebsiella pneumoniae isolates from eight patients. a further three isolates were obtained from the intestinal tract and pharyngeal colonization. all isolates were multidrug-resistant (mdr), including being res ... | 2011 | 21668577 |
| pyogenic liver abscess in older adults: comparison with younger individuals. | 2011 | 21668934 | |
| consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in asia-pacific region. | urinary tract infections (utis) are among the most prevalent infectious diseases in the general population. they cause a substantial financial burden in the community and are associated with significant morbidity and mortality, particularly in hospitals. with increased rates of antimicrobial resistance, especially in the asia-pacific region, treatment of complicated utis (cutis) can be challenging for clinicians. consideration of an optimal antimicrobial agent should be based on local resistance ... | 2011 | 21669223 |
| antimicrobial susceptibilities of commonly encountered bacterial isolates to fosfomycin determined by agar dilution and disk diffusion methods. | we studied the antimicrobial activity of fosfomycin against 960 strains of commonly encountered bacteria associated with urinary tract infection using standard agar dilution and disk diffusion methods. species studied included 3 common species of enterobacteriaceae, pseudomonas aeruginosa, acinetobacter baumannii, and stenotrophomonas maltophilia; methicillin-susceptible and -resistant staphylococcus aureus; and vancomycin-susceptible and resistant enterococcus faecalis and e. faecium. mics and ... | 2011 | 21670185 |
| susceptibility of klebsiella pneumoniae isolates from intra-abdominal infections and molecular characterization of ertapenem-resistant isolates. | a total of 2,841 clinical isolates of klebsiella pneumoniae from intra-abdominal infections worldwide were collected in the study for monitoring antimicrobial resistance trends (smart) during 2008 and 2009. overall, 22.4% of isolates had extended-spectrum ╬▓-lactamases (esbls). the most active antibiotics among the 11 tested were imipenem, amikacin, and ertapenem, though even these, like all other comparators, were less consistently active against esbl-positive isolates than against esbl-negativ ... | 2011 | 21670192 |
| multiresistance, beta-lactamase-encoding genes and bacterial diversity in hospital wastewater in rio de janeiro, brazil. | aims:ôçé to investigate the bacterial diversity, antimicrobial resistance patterns and types of beta-lactamase genes in gram-negative bacteria isolated from a hospital sewage treatment plant. methods and results:ôçé between july and december 2008, we collected samples from influent, clarifier tank effluent and chlorine contact tank effluent from a sewage treatment plant service of a hospital located in the city of rio de janeiro, brazil. of the 221 isolates identified, 40% were characterized as ... | 2011 | 21672095 |
| synthesis of silver nanoparticles in montmorillonite and their antibacterial behavior. | silver nanoparticles (ag nps) were synthesized by the chemical reducing method in the external and interlamellar space of montmorillonite (mmt) as a solid support at room temperature. agno(3) and nabh(4) were used as a silver precursor and reducing agent, respectively. the most favorable experimental conditions for synthesizing ag nps in the mmt are described in terms of the initial concentration of agno(3). the interlamellar space limits changed little (d-spacing = 1.24-1.47 nm); therefore, ag ... | 2011 | 21674015 |
| wide dissemination of extended-spectrum beta-lactamase (esbl)-producing escherichia coli and klebsiella spp. in acute care and rehabilitation hospitals. | summarya prospective surveillance system for extended-spectrum beta-lactamase-producing escherichia coli (esbl-e) and esbl-producing klebsiella spp. (esbl-k) was implemented in 39 german hospitals with the aim of determining the incidence densities (ids) of community-onset and hospital-onset cases and of identifying risk factors for high ids of hospital-onset cases. during 2008, 2081 esbl-e/k cases were documented. esbl-e cases (n=1330, 63-à9%) were more common than esbl-k cases (n=751, 36-à1%), ... | 2011 | 21676355 |
| emerging severe and fatal infections due to klebsiella pneumoniae in two university hospitals in france. | severe infections caused by hypermucoviscous klebsiella pneumoniae have been reported in southeast asian countries over the past several decades. this report shows their emergence in france, with 12 cases observed during a 2-year period in two university hospitals. two clones (sequence type 86 [st86] and st380) of serotype k2 caused five rapidly fatal bacteremia cases, three of which were associated with pneumonia, whereas seven liver abscess cases were caused by k1 strains of st23. | 2011 | 21677064 |
| production of a novel bioflocculant mnxy1 by klebsiella pneumoniae strain ny1 and application in precipitation of cyanobacteria and municipal wastewater treatment. | aims:ôçé to isolate and characterize the novel bioflocculant-producing bacteria, to optimize the bioflocculant production and to evaluate its potential applications. methods and results:ôçé klebsiella pneumoniae strain ny1, a bacterium that produces a novel bioflocculant (mnxy1), was selected on the chemically defined media. it was classified according to the 16s rrna gene sequence, morphological and microscopic characteristics. mnxy1 was characterized to contain 26% protein and 66% total sugar. ... | 2011 | 21679283 |
| clinical and economic burden of community-acquired pneumonia amongst adults in the asia-pacific region. | community-acquired pneumonia (cap) is an important cause of mortality and morbidity amongst adults in the asia-pacific region. literature published between 1990 and may 2010 on the clinical and economic burden of cap amongst adults in this region was reviewed. cap is a significant health burden with significant economic impact in this region. chronic obstructive pulmonary disease, cardiovascular disease, diabetes mellitus and advanced age were risk factors for cap. aetiological agents included s ... | 2011 | 21683553 |
| mucosal surveillance cultures in predicting gram-negative late-onset sepsis in neonatal intensive care units. | this study aimed to examine the spectrum and time course of gut and nasopharyngeal colonization with gram-negative micro-organisms, and to define the value of surveillance cultures in predicting late-onset sepsis in neonates admitted to neonatal intensive care units. nasopharyngeal and rectal swabs were collected on admission and twice weekly thereafter in 278 neonates admitted within the first 72-áh of life with risk factors of early-onset sepsis. sterile body fluid cultures were obtained on ad ... | 2011 | 21684633 |
| gas forming liver abscess caused by klebsiella pneumoniae. | 2009 | 21686710 | |
| results of urine culture and antimicrobial sensitivity tests according to the voiding method over 10 years in patients with spinal cord injury. | we studied the results of urine cultures and antimicrobial sensitivity tests according to the voiding method used by spinal cord injury (sci) patients over a recent 10-year period. | 2011 | 21687395 |
| does it ever make sense to treat a bacterial infection with a drug against which the responsible pathogen possesses a resistance mechanism? | 2011 | 21689208 | |
| genetic evolution and clinical impact in extended-spectrum +¦-lactamase-producing escherichia coli and klebsiella pneumoniae. | the emergence of extended-spectrum +¦-lactamase (esbl)-producing bacteria, particularly escherichia coli and klebsiella pneumoniae, is now a critical concern for the development of therapies against bacterial infection. esbls consist of three major genetic groups: tem, shv, and ctx-m types. nosocomial infections due to tem and shv-producing k. pneumoniae strains were frequently documented until the late 1990s. the number of reports on community-acquired infections caused by ctx-m-producing e. co ... | 2011 | 21689785 |
| the challenges of antimicrobial drug resistance in greece. | antimicrobial drug resistance rates in greece are among the highest in europe. the prevalence of carbapenem-resistant gram-negative species has increased considerably, including endemic strains in intensive care units. pandrug-resistant klebsiella pneumoniae, acinetobacter baumannii, and pseudomonas aeruginosa are sporadically reported. methicillin-resistant staphylococcus aureus and vancomycin-resistant enterococcus rates are also high in greek hospitals. multidrug resistance increases risk of ... | 2011 | 21690626 |
| bactericidal activity identified in 2s albumin from sesame seeds and in silico studies of structure-function relations. | pathogenic bacteria constitute an important cause of hospital-acquired infections. however, the misuse of available bactericidal agents has led to the appearance of antibiotic-resistant strains. thus, efforts to seek new antimicrobials with different action mechanisms would have an enormous impact. here, a novel antimicrobial protein (siamp2) belonging to the 2s albumin family was isolated from sesamum indicum kernels and evaluated against several bacteria and fungi. furthermore, in silico analy ... | 2011 | 21691771 |
| impact of a clonal outbreak of extended-spectrum {beta}-lactamase-producing klebsiella pneumoniae in the development and evolution of bloodstream infections by k. pneumoniae and escherichia coli: an 11 year experience in oxfordshire, uk. | objectives the objectives of this study were: (i) to describe an outbreak of multidrug-resistant klebsiella pneumoniae in our population; (ii) to identify the potential source of this outbreak by examining antibiotic resistance trends in urocultures; (iii) to evaluate the contribution of this outbreak to resistance patterns over time in the two commonest gram-negative blood culture isolates, namely k. pneumoniae and escherichia coli; and (iv) to assess risk factors for multidrug resistance and t ... | 2011 | 21693458 |
| fluoroquinolone resistance in escherichia coli and klebsiella pneumoniae over 18 years: effect of different systems for eliminating duplicates. | 2011 | 21693462 | |
| deep neck abscess: an analysis of microbial etiology and the effectiveness of antibiotics. | the objective was to demonstrate the aerobic and anaerobic microbiology of deep neck space abscess and to analyze the coverage rate of different empiric antimicrobial agents. a retrospective review of hospitalized patients with deep neck abscess diagnosed at a tertiary-care, general hospital between april 2001 and october 2006. the study enrolled 100 patients. the bacterial cultures of 89 patients yielded positive results (89%). the predominant aerobes were viridans streptococci, klebsiella pneu ... | 2008 | 21694873 |
| potential role of tigecycline in the treatment of community-acquired bacterial pneumonia. | tigecycline is a member of the glycylcycline class of antimicrobials, which is structurally similar to the tetracycline class. it demonstrates potent in vitro activity against causative pathogens that are most frequently isolated in patients with community-acquired bacterial pneumonia (cabp), including (but not limited to) streptococcus pneumoniae (both penicillin-sensitive and -resistant strains), haemophilus influenzae and moraxella catarrhalis (including +¦-lactamase-producing strains), klebs ... | 2011 | 21694911 |
| macrophage genetic reprogramming during chronic peritonitis is augmented by lps pretreatment. | background: persistent and tertiary chronic peritonitis is a clinically challenging problem especially in those who are critically ill. this could be attributed to a state of immune-paralysis, known as microbial tolerance. microbial tolerance is the diminished pro-inflammatory protein response following repeated stimulation by numerous pathogen-associated molecular patterns (pamps) of varying origins, which we have shown in this novel model of chronic peritonitis. we aimed in this study to inves ... | 2011 | 21696761 |
| bacterial community composition of biological degreasing systems and health risk assessment for workers. | biological degreasing system is a new technology based on the degradation capabilities of microorganisms to remove oil, grease, or lubricants from metal parts. no data is available about the potential biological health hazards in such system. thus, a health risk assessment linked to the bacterial populations present in this new degreasing technology is, therefore, necessary for workers. we performed both cultural and molecular approaches in several biological degreasing systems for various indus ... | 2011 | 21698403 |
| antimicrobial activity of liposome encapsulated cyclo(l-tyrosyl-l-prolyl). | various studies have shown the potentially beneficial biological activities of cyclic dipeptides and in particular, cyclo(l-tyrosyl-l-prolyl) (cyclo(tyr-pro)) has shown fair antibacterial activity in vitro. this study aimed to determine if liposome encapsulation would have any significant effects on the antibacterial activity of this compound. the thin-film hydration method with extrusion was used to produce small unilamellar vesicles containing cyclo(tyr-pro) that were shown to have an average ... | 2011 | 21699080 |
| an optimized method for suicide vector-based allelic exchange in klebsiella pneumoniae. | klebsiella pneumoniae is an important and versatile bacterium that can be found in diverse environments and is also a frequent cause of human infections. limited data exists on the mechanisms of interaction between k. pneumoniae and the human host and of adaptations to other environments. coupled with the high genetic diversity of this species, these factors highlight the necessity for substantial further k. pneumoniae-focused molecular genetics studies. in this report we describe a simple and e ... | 2011 | 21699924 |
| risk factors associated with short-term post-treatment outcomes of clinical mastitis. | the objectives of this study were to characterize 60-d outcomes after treatment of mild (abnormal milk) and moderate (abnormal milk and abnormal udder) cases of clinical mastitis (cm) occurring in a single quarter of cows on wisconsin farms (n=4) and to determine risk factors associated with those outcomes. duplicate milk samples were collected from the affected quarter of each cow for microbiological analysis at the onset of cm (pre) and 21 d later (post). cows were treated only in the affected ... | 2011 | 21700025 |
| factors associated with the quality of well water and the prevalence of waterborne diseases in the municipality of abomey-calavi in benin. | the objective of this work is to assess the factors associated with the water quality of household wells, suggest solutions to improve it, and study the prevalence of water-borne diseases in this community. the quality of well water and the prevalence of waterborne diseases in the municipality were studied by analysis of the microbiological indicators currently used to assess drinking-water quality and the retrospective study of waterborne diseases treated in the local health centres. the wells ... | 2011 | 21700557 |
| lateral buttock congenital dermal sinus tract. | a 6-month-old female presented with purulent discharge from a dimple in the right lateral buttock. a subcutaneous abscess was palpated on the right paravertebral region at the l5-s1 level. she had low-grade fever with laboratory findings of leukocytosis and elevation of c-reactive protein levels. klebsiella and enterococcus species were cultured from the pus. computed tomography (ct) clearly showed a tract traversing the subcutaneous tissue and connecting to the abscess. magnetic resonance (mr) ... | 2011 | 21701114 |
| horizontal transfer of antimicrobial resistance by extended-spectrum +¦ lactamase-producing enterobacteriaceae. | the purpose of this work was to study the acquisition of new antibiotic-resistant genes carried by extended spectrum +¦-lactamase (esbl)-producing enterobacteriaceae via horizontal transfer to understand their rampant spread in the hospitals and in the community. | 2011 | 21701662 |
| molecular detection and epidemiology of extended-spectrum beta-lactamase genes prevalent in clinical isolates of klebsiella pneumoniae and e coli from trinidad and tobago. | the epidemiology of extended-spectrum beta-lactamase (esbl) producing e coli and k pneumoniae is complex and varies among hospitals and countries. this study aimed at describing the molecular detection and epidemiology of esbl subtypes prevalent in clinical isolates of k pneumonia and e coli in trinidad and tobago. | 2010 | 21702229 |
| cloning, expression, and enzymatic activity of acinetobacter baumannii and klebsiella pneumoniae acetyl-coenzyme a carboxylases. | pathogenic gram-negative bacteria are a major public health concern because they are causative agents of life-threatening hospital-acquired infections. due to the increasing rates of resistance to available antibiotics, there is an urgent need to develop new drugs. acetyl-coenzyme a carboxylase (accase) is a promising target for the development of novel antibiotics. we describe here the expression, purification, and enzymatic activity of recombinant accases from two clinically relevant gram-nega ... | 2011 | 21704013 |
| bacterial contamination of saudi "one" riyal paper notes. | fomites are inanimate objects that are capable of absorbing, harboring and transmitting infectious microorganisms. paper currency, an exchangeable fomite, is constantly subjected to contamination. this study investigated bacterial contamination on the saudi one riyal paper note. two hundred one riyal bills (100 4th version and 100 5th version) were collected in the city of jeddah for examination. the notes were examined for bacterial contamination using blood agar and macconkey agar. eighty-eigh ... | 2011 | 21706951 |
| arthritis, osteomyelitis, septicemia and meningitis caused by klebsiella in a low-birth-weight newborn: a case report. | abstract: | 2011 | 21707974 |
| analysis of the networks controlling the antimicrobial-peptide-dependent induction of klebsiella pneumoniae virulence factors. | antimicrobial peptides (aps) impose a threat to the survival of pathogens, and it is reasonable to postulate that bacteria have developed strategies to counteract them. polymyxins are becoming the last resort to treat infections caused by multidrug-resistant gram-negative bacteria and, similar to aps, they interact with the anionic lipopolysaccharide. given that polymyxins and aps share the initial target, it is possible that bacterial defense mechanisms against polymyxins will be also effective ... | 2011 | 21708987 |
| in vitro spectrum of activity of finafloxacin, a novel, ph-activated fluoroquinolone, under standard and acidic conditions. | finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. the aim of this study was to define the in vitro ph-activity relationship. finafloxacin exhibited optimal antibacterial activity between ph 5.0 and 6.0 at which mics were 4- to 8-fold lower than those determined at neutral ph. these observations were then confirmed against a larger collection of bacteria. these data suggest that finafloxacin could potentially offer a therapeutic advanta ... | 2011 | 21709094 |
| in vitro potency of various polymyxin b components. | 2011 | 21709096 | |
| pus in the ventricles of a patient with a lumbar cerebrospinal fluid drain for a thoracoabdominal aneurysm repair. | 2011 | 21709541 | |
| changes in bacterial resistance patterns in children with urinary tract infections on antimicrobial prophylaxis at university hospital in split. | we assessed prevalence and resistance of uropathogens on antimicrobial agents (aa) from urine cultures (uc) in children hospitalized with urinary tract infections (uti) at university hospital in split. | 2011 | 21709628 |
| antimicrobial resistance patterns of uropathogens among children in istanbul, turkey. | urinary tract infections are a common cause of end-stage renal disease in turkey. this prospective study investigated the antibiotic resistance patterns of uropathogens in order to recommend appropriate therapeutic protocols for children with urinary tract infections in istanbul, turkey. between october 2007 and october 2008, children presenting with a first episode of urinary tract infection to a pediatric outpatient clinic were enrolled in the study. urine samples were cultured, and antimicrob ... | 2011 | 21710858 |
| comparison of ctx-m-14- and ctx-m-15-producing escherichia coli and klebsiella pneumoniae isolates from patients with bacteremia. | recently, ctx-m-15-producing enterobacteriaceae has disseminated worldwide. to better understand the success of ctx-m-15-type extended-spectrum +¦-lactamase, we compared the ctx-m-15-producing escherichia coli and klebsiella pneumoniae isolates with ctx-m-14-producing e. coli and k. pneumoniae isolates that had been more prevalent before the recent increase of ctx-m-15 in korea. | 2011 | 21712135 |
| changes in acute-phase proteins and cytokines in serum and milk whey from dairy cows with naturally occurring peracute mastitis caused by klebsiella pneumoniae and the relationship to clinical outcome. | this study was conducted to evaluate the changes in acute-phase proteins and cytokine concentrations in dairy cows with naturally occurring peracute klebsiella pneumoniae (k. pneumoniae) mastitis and their association with the outcome of the disease. seventeen holstein cows with k. pneumoniae mastitis from 8 dairy farms were divided on the basis of outcome after local and systemic therapy into 2 groups comprising 8 euthanized cows and 9 that recovered. changes in acute-phase proteins and cytokin ... | 2011 | 21712644 |
| evaluations of bacterial contaminated full thickness burn wound healing in sprague dawley rats treated with tualang honey. | the effect of tualang honey on wound healing in bacterial contaminated full-thickness burn wounds was evaluated in 36 male sprague dawley rats. | 2011 | 21713196 |
| [antimicrobial resistance of gram negative bacilli isolated from terciary-care hospitals in colombia]. | antimicrobial resistance has been identified as one of the major public health problems worldwide. to facilitate its control, bacterial resistance levels must be monitored permanently by effective surveillance systems. | 2010 | 21713339 |
| physicochemical and microbiological assessment of recreational and drinking waters. | the present study was aimed to make an assessment of health risk due to pollution and human pathogenic bacteria associated with the recreational and drinking water sources in twin densely populated holy indian cities ayodhya and faizabad. though physicochemical studies revealed that the water available in the area is under recommended limits for human use, it is unsafe on account of poor microbiological quality of surface and ground water in the region. the most probable number (mpn) test result ... | 2011 | 21713494 |
| inflammation restraining effects of prostaglandin e2 on natural killer-dendritic cell (nk-dc) interaction are imprinted during dc maturation. | among prostaglandins (pgs), pge2 is abundantly expressed in various malignancies and is probably one of many factors promoting tumor growth by inhibiting tumor immune surveillance(.) in the current study, we report on a novel mechanism by which pge2 inhibits in vitro natural killer-dendritic cell (nk-dc) crosstalk and thereby innate and adaptive immune responses via its effect on nk-dc crosstalk. the presence of pge2 during ifn-+¦/membrane fraction of klebsiella pneumoniae dc maturation inhibits ... | 2011 | 21715307 |
| contemporary activity of colistin and polymyxin b against a worldwide collection of gram-negative pathogens: results from the sentry antimicrobial surveillance program (2006-09). | objectives to comparatively evaluate the antimicrobial activities of colistin and polymyxin b with those of other antimicrobials against a worldwide collection of 40ôçè625 gram-negative bacilli. methods antimicrobial susceptibility testing was performed and interpreted using the clsi broth microdilution method except for colistin against enterobacteriaceae. results the polymyxins showed potent in vitro activities (mic(90), ôëñ0.5-1 mg/l) against this large collection of clinical isolates, with v ... | 2011 | 21715434 |
| usefulness of c-reactive protein for evaluating clinical outcomes in cirrhotic patients with bacteremia. | the purpose of this study was to evaluate the value of initial c-reactive protein (crp) as a predictor of clinical outcome and to investigate whether follow-up crp measurement is useful for the prediction of the clinical outcome of bloodstream infections in patients with liver cirrhosis (lc), whose crp production in response to infection may be attenuated. | 2011 | 21716910 |
| molecular analysis of a prolonged spread of klebsiella pneumoniae co-producing dha-1 and shv-12 +¦-lactamases. | the study investigated molecular mechanisms for prolonged nosocomial spread of multidrug-resistant klebsiella pneumoniae co-producing plasmid-mediated ampc +¦-lactamase dha-1 and extended-spectrum +¦-lactamase shv-12. forty-eight clinical isolates of k. pneumonia, resistant to the extended-spectrum cepha-losporins, were collected in a 750-bed university hospital over a year. the isolates were characterized for pcr-based +¦-lactamase genotypes, isoelectric focusing and pulsed-field gel electropho ... | 2011 | 21717319 |
| antagonistic effect of lactobacillus strains against gas-producing coliforms isolated from colicky infants. | infantile colic is a common disturb within the first 3 months of life, nevertheless the pathogenesis is incompletely understood and treatment remains an open issue. intestinal gas production is thought to be one of the causes of abdominal discomfort in infants suffering from colic. however, data about the role of the amount of gas produced by infants' colonic microbiota and the correlation with the onset of colic symptoms are scanty. the benefit of supplementation with lactobacilli been recently ... | 2011 | 21718486 |
| [evolution of susceptibility to antibiotics of escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumanii, in a university hospital center of beirut between 2005-áand 2009.] | introduction: until recently, multiresistant bacteria were only limited to hospitals. however, they are now responsible for community acquired infections, affecting people who have had no contact with the hospital environment. several mechanisms are associated with these resistances. the production of betalactamases is however the predominant mechanism and especially the production of extended spectrum beta-lactamases or esbl by strains of escherichia coli and klebsiella pneumoniae, which mediat ... | 2011 | 21719212 |
| colonization of the gut with gram negative bacilli, its association with neonatal sepsis and its clinical relevance in a developing country. | this study examines the pattern of colonization of the neonatal gut by aerobic gram negative bacilli (gnb) and evaluates the association between gut colonization and sepsis in the developing world. this deserves attention because of the high incidence of sepsis and the differences in hygienic environment in developing countries compared to the developed world. the study was carried out on neonates in a tertiary care government hospital. the serial gut samples were analyzed (gastric aspirate, ga- ... | 2011 | 21719575 |
| high mobility group nucleosomal binding domain 2 protein protects bladder epithelial cells from klebsiella pneumoniae invasion. | due to the predominance of multiple-antibiotic-resistant klebsiella pneumoniae strains, the search for new approaches for the prevention of k. pneumoniae infections is now under intensive investigation. the objective of the present study was to investigate the effects of high mobility group nucleosomal binding domain 2 (hmgn2) protein, which acts on the bladder epithelial cells t 24, on the invasion of k. pneumoniae 03183 and explore its possible mechanisms. pretreatment with hmgn2 significantly ... | 2011 | 21720014 |
| extended-spectrum beta-lactamase-mediated resistance among bacterial isolates recovered from ocular infections. | purpose: to evaluate resistances mediated by extended-spectrum +¦-lactamases (esbls) and ampc +¦-lactamases among gram-negative bacteria recovered from ocular infections. methods: as per the clinical laboratory standards institute m100-s-16 document, a total of 135 gram-negative bacilli were recovered from ocular specimens and were subjected to phenotypic confirmation for esbl production by the double-disc synergy test, cephalosporin and clavulanate combination disc test and e test, and, for amp ... | 2011 | 21720185 |
| a novel complex class 1 integron found in a klebsiella pneumoniae isolate from portugal. | klebsiella pneumoniae kp1 carrying a novel complex class 1 integron was isolated from an inanimate surface of a female ward sanitary facility in the hospital infante d. pedro, aveiro, central portugal. the integron consists of two variable regions (vrs); vr1 was previously described in escherichia coli and vibrio cholerae, and vr2 contains an in37-like structure and is located downstream of an iscr1 element. the integron was found on a plasmid of 225 kb. the qnrb10 gene, although present, is not ... | 2011 | 21722254 |
| outcome of carbapenem resistant klebsiella pneumoniae bloodstream infections. | the aim of this study was to evaluate the impact of carbapenem-resistant k. pneumoniae bloodstream infections on mortality. during the study period 42, 68 and 120 patients were identified with carbapenem-resistant, extended-spectrum β-lactamase producers (esbl) and susceptible k. pneumoniae bloodstream infections, respectively. patients with carbapenem-resistant k. pneumoniae had higher rates of prior antimicrobial exposure, other nosocomial infections, and use of invasive devices. infection-rel ... | 2011 | 21722257 |
| klebsiella pneumoniae: development of a mixed population of carbapenem and tigecycline resistance during antimicrobial therapy in a kidney transplant patient. | clin microbiol infect abstract: nine isolates of klebsiella pneumoniae were isolated from a renal transplant patient suffering from recurrent urosepsis over a period of 4ôçâmonths. imipenem resistance was detected after imipenem-ertapenem therapy. when treatment was switched to tigecycline the k.-ápneumoniae developed resistance to tigecycline (micôçâ=ôçâ8ôçâmg/l). the nine isolates were tested by determination of agar dilution mics, phenotypic carbapenemase, extended-spectrum beta-lactamases an ... | 2011 | 21722259 |
| preliminary investigation of a mice model of klebsiella pneumoniae subsp. ozaenae induced pneumonia. | in the present study, we comparatively assessed the pathophysiological mechanisms developed during lung infection of balb/c female mice infected by an original wild type klebsiella pneumoniae subsp. ozaenae strain (ch137) or by a referent subspecies k. pneumoniae. subsp. pneumoniae strain (atcc10031). the mice infected with 2.10(6)-ácfu k. p. subsp. pneumoniae (n-á=-á10) showed transient signs of infection and all of them recovered. all of those infected with 1.10(6)-ácfu k. p. subsp. ozaenae (n ... | 2011 | 21723409 |
| diverse prevalence of 16s rrna methylase genes arma and rmtb amongst clinical multidrug-resistant escherichia coli and klebsiella pneumoniae isolates. | in this study, 112 escherichia coli and 55 klebsiella pneumoniae isolates with a multidrug-resistant (mdr) phenotype were collected from 2007 to 2009. all isolates simultaneously exhibited resistance to cefotaxime (or ceftazidime), ciprofloxacin (or levofloxacin) and amikacin. plasmid-mediated 16s rrna methylases, including arma, rmta, rmtb, rmtc, rmtd, rmte and npma, were detected by polymerase chain reaction (pcr) amplification. common +¦-lactamase genes, including bla(tem), bla(shv), bla(ctx- ... | 2011 | 21724374 |
| pharmacodynamics of meropenem in critically ill patients with febrile neutropenia and bacteraemia. | the bactericidal activity of β-lactams is determined by the time that concentrations in tissue and serum are above the minimum inhibitory concentration (t>mic) for the pathogen. the aim of this study was to compare the probability of target attainment (pta) and the cumulative fraction of response (cfr) for meropenem between administration by bolus injection and a 3-h infusion. the study was a randomised, three-way, cross-over design in eight febrile neutropenic patients with bacteraemia. each su ... | 2011 | 21726984 |
| untreated primary thyroid lymphoma in an elderly woman. | 2011 | 21727773 | |
| antimicrobial activity of essential oils of physalis angulata. l. | the need for a reduction in drug resistance led to the investigation of argemone mexicana l. as an agent against bacillus subtilis, klebsiella pneumoniae, staphylococcus aureus, pseudomonas aeruginosa, candida albicans, candida stellatoidea and candida torulopsis, using well diffusion and minimum inhibitory concentrations methods. the sensitivity of bacillus subtilis, klebsiella pneumoniae, pseudomonas aeruginosa and staphylococcus aureus to the essential oils of both the aerial and root parts w ... | 2010 | 21731161 |
| aetiology of community-acquired urinary tract infection and antimicrobial susceptibility patterns of uropathogens isolated. | antibiotic resistance among uropathogens causing urinary tract infection (uti) is increasing worldwide. in most cases of uti, family physicians can provide empirical treatment without the benefit of a pre-therapy urine culture. knowledge of the aetiology and antimicrobial susceptibility patterns of uropathogens is important in order to determine the best empiric treatment option. this study aimed to determine the aetiology and antimicrobial susceptibility of uropathogens in culture-positive, com ... | 2011 | 21731993 |
| antibiotic therapy in neonatal and pediatric septic shock. | severe sepsis accounts for nearly 4,500 deaths (mortality rate 10%), and is responsible for nearly $2 billion annual healthcare expenditure in the united states. early and speedy treatment of critically ill septic patients can halt or reduce the likelihood of physiologic progression to multi-system organ failure. a cornerstone of this therapeutic strategy is antibiotic administration. in this review, we discuss the empirical treatment strategies for the treatment of early and late neonatal sepsi ... | 2011 | 21732046 |
| establishment of the first international repository for transfusion-relevant bacteria reference strains: isbt working party transfusion-transmitted infectious diseases (wp-ttid), subgroup on bacteria. | backgroundôçé bacterial contamination of platelet concentrates (pcs) still remains a significant problem in transfusion with potential important clinical consequences, including death. the international society of blood transfusion working party on transfusion-transmitted infectious diseases, subgroup on bacteria, organised an international study on transfusion-relevant bacteria references to be used as a tool for development, validation and comparison of both bacterial screening and pathogen re ... | 2011 | 21732948 |
| real-time detection of blakpc in clinical samples and surveillance specimens. | a real-time pcr assay was developed targeting the bla(kpc) responsible for klebsiella pneumoniae carbapenemase (kpc)-mediated carbapenem resistance and was validated for testing colonies or enrichment broth cultures. the assay accurately detects kpc-containing strains with high analytical specificity and sensitivity. | 2011 | 21734030 |
| [comparison of two phenotypic methods for detecting the production of extended-spectrum beta-lactamases by hospital klebsiella pneumoniae strains]. | in the period 2006-2008, the republican emergence medical care center.isolated 2997 enterobacteria, 48.9% of which belonged to klebsiella pneumoniae. confirming phenotypic methods, such as double disk method (ddm) and double disk synergy test (ddst), were used to examine 64 k. pneumoniae strains that had been regarded as being suspected to produce extended-spectrum beta-lactamases (esbl) during a preliminary screening. of the 64 k. pneumoniae strains, 6 (9.4%) were unsusceptible to clavulanate a ... | 2011 | 21735683 |
| purple urine. | 2011 | 21738253 | |
| fecal carriage of serotype k1 klebsiella pneumoniae st23 strains closely related to liver abscess isolates in koreans living in korea. | we determined the fecal carriage rate of serotype k1 klebsiella pneumoniae in healthy koreans and studied their genetic relationship with liver abscess isolates. we compared the carriage according to the country of residence. the stool specimens were collected through health promotion programs in korea. k. pneumoniae strains were selected and tested for k1 by pcr. serotype k1 isolates were characterized by multilocus sequence typing and pulsed field gel electrophoresis. a total of 248ôçëk. pneum ... | 2011 | 21739348 |