Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| rega proteins from phage t4 and rb69 have conserved helix-loop groove rna binding motifs but different rna binding specificities. | the rega proteins from the bacteriophage t4 and rb69 are translational repressors that control the expression of multiple phage mrnas. rega proteins from the two phages share 78% sequence identity; however, in vivo expression studies have suggested that the rb69 rega protein binds target rnas with a higher affinity than t4 rega protein. to study the rna binding properties of t4 and rb69 rega proteins more directly, the binding sites of rb69 rega protein on synthetic rnas corresponding to the tra ... | 2001 | 11222767 |
| glottic cancer in ontario, canada and the seer areas of the united states. do different management philosophies produce different outcome profiles? | we compared the management and outcome of glottic cancer in ontario, canada to that in the surveillance, epidemiology and end results (seer) program areas in the united states to determine whether the greater use of primary radiotherapy with surgery reserved for salvage in ontario was associated with similar survival and better larynx retention rates than the u.s. approach where primary surgery is used more often. electronic, clinical and hospital data were linked to cancer registry data and sup ... | 2001 | 11223328 |
| prognostic implications of aberrations in p16/prb pathway in urothelial bladder carcinomas: a multivariate analysis including p53 expression and proliferation markers. | to assess the prognostic value of the expression of two negative regulators of the cell cycle, namely cdkn2/ink4a gene product (p16) and retinoblastoma gene product (prb), in urinary bladder cancer in relation to clinicopathological parameters, proliferative fraction and p53 protein accumulation. | 2001 | 11223676 |
| accuracy requirements for image-guided spinal pedicle screw placement. | accuracy requirement analysis for image-guided pedicle screw placement. | 2001 | 11224881 |
| target gland functional status in patients with non-cushing's pituitary macroadenomas undergoing transsphenoidal microsurgery. | hypopituitarism occurring in patients with pituitary macroadenoma may be reversible after pituitary microsurgery, and surgery itself can lead to hypopituitarism. this study was undertaken to evaluate target gland function prospectively in patients of non-cushing's pituitary macroadenoma undergoing trans-sphenoidal microsurgery. | 2001 | 11225134 |
| effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study. | in aging humans, night levels of melatonin (mel) decline progressively. also thyroid and gonadal functions decline during aging while gonadotropins (luteotropic hormone (lh) and follicle stimulating hormone (fsh)) steadily increase. a desynchronization of pineal circadian cyclicity as expressed by the progressive decrease of the mel night peak may be permissively linked to the onset and progression of menopause. we studied the effects of exogenous, evening administration of mel on the level of h ... | 2001 | 11226744 |
| liver transplantation for biliary atresia associated with malignant hepatic tumors. | the authors report 3 cases of liver transplantations in children between 4 and 10 years of age, complicated with malignant hepatic tumors after biliary atresia. the preoperative abdominal computed tomography (ct) scans of all 3 cases showed hepatic masses. the serum alpha-fetoprotein levels were elevated highly in 2 cases. after living-related liver transplantation (lrlt), the pathologic findings of the masses in the resected livers showed hepatocellular carcinoma in 2 cases and hepatoblastoma i ... | 2001 | 11226990 |
| effect of acute elevation of igf-i on circulating gh, tsh, insulin, igf-ii and igfbp-3 levels in non-endocrine short stature (ness). | it is not clear whether acute and slight elevation of serum igf-i, which does not affect blood glucose levels, modulates circulating gh levels. to clarify this, small doses of recombinant human igf-i (rhigf-i, 5 microg/kg, i.v.) were administered as a bolus to 10 children with non-endocrine short stature (ness) (5 males and 5 females, 11.2+/-0.7 yr old) after an overnight fast. physiological saline was administered intravenously to sex- and age-matched ness controls (5 males and 5 females, 10.9+ ... | 2001 | 11227726 |
| hyperthyroidism in a patient with tsh-producing pituitary adenoma coexisting with thyroid papillary adenocarcinoma. | a 27-year-old woman who presented with a left thyroid nodule was found to have hyperthyroidism caused by a syndrome of inappropriate secretion of tsh. the levels of free t3, free t4 and tsh were 9.50 pg/ml, 4.05 ng/dl and 2.16 microu/ml, respectively. magnetic resonance imaging of the head revealed a pituitary macroadenoma. the tsh response to trh stimulation was normal and responses of other anterior pituitary hormones to stimulation tests were also normally preserved. administration of octreot ... | 2000 | 11228048 |
| transient thyrotoxicosis and hypothyroidism following administration of the gnrh agonist leuprolide acetate. | a 45-year-old women with chronic idiopathic thrombocytopenic purpura was given monthly injections of the gnrh agonist leuprolide acetate for the treatment of uterine leiomyoma. two weeks after the fifth injection, she showed mild symptoms of thyrotoxicosis. at that time, serum thyroxin (t4) and triiodothyronine (t3) levels were elevated whereas tsh level was suppressed. anti-thyroglobulin (anti-tg) and anti-thyroid peroxidase (anti-tpo) antibodies were positive, whereas tsh binding inhibitory im ... | 2000 | 11228054 |
| measurement of serum concentrations of free thyroxine, total thyroxine, and total triiodothyronine in cats with hyperthyroidism and cats with nonthyroidal disease. | to determine the usefulness of measuring serum free thyroxine (t4) concentration as a diagnostic test for hyperthyroidism in cats, and to determine the influence of nonthyroidal disease on free t4 concentration in cats without hyperthyroidism. | 2001 | 11229503 |
| accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. | incomplete surgical removal of the circumferential tumour spread is believed to be the main cause of local recurrence after resection of rectal cancer. this study assessed the accuracy of magnetic resonance imaging (mri) with a phased-array coil for preoperative staging and prediction of the distance of the tumour from the circumferential resection margin in a total mesorectal excision. | 2001 | 11229667 |
| dose resolution in radiotherapy polymer gel dosimetry: effect of echo spacing in mri pulse sequence. | in polymer gel dosimetry using magnetic resonance imaging, the uncertainty in absorbed dose is dependent on the experimental determination of t2. the concept of dose resolution (dpdelta) of polymer gel dosimeters is developed and applied to the uncertainty in dose related to the uncertainty in t2 from a range of t4 encountered in polymer gel dosimetry. dpdelta is defined as the minimal separation between two absorbed doses such that they may be distinguished with a given level of confidence, p. ... | 2001 | 11229725 |
| antisense inhibition of thyrotropin-releasing hormone reduces arterial blood pressure in spontaneously hypertensive rats. | thyrotropin-releasing hormone (trh) plays an important role in central cardiovascular regulation. recently, we described that the trh precursor gene overexpression induces hypertension in the normal rat. in addition, we published that spontaneously hypertensive rats (shr) have central extrahypothalamic trh hyperactivity with increased trh synthesis and release and an elevated trh receptor number. in the present study, we report that intracerebroventricular antisense (as) treatment with a phospho ... | 2001 | 11230301 |
| the effect of recombinant human tsh on the thyroid (123)i uptake in iodide treated normal subjects. | radioactive iodine therapy is often successful in the treatment of toxic or non-toxic multinodular goiter. however, when the patient has been exposed to iodine in the form of medication or radiocontrast agents prior to therapy, the thyroid radioactive iodine is often too low for successful ablation. recently, administration of 0.9 mg of recombinant human tsh (rhtsh) has been shown to nearly double the 24-hour thyroid radioactive iodine uptake (raiu) in euthyroid men living in the united states. ... | 2001 | 11232037 |
| management of ipsilateral intrapulmonary metastases in the new tnm system for non-small cell lung cancer. | recently, the union internationale contre le cancer and american joint committee on cancer reclassified not only tnm staging but also ipsilateral intrapulmonary metastases (pm) as t4 in a same lobe or m1 in different lobes. to determine whether the new pm staging is appropriate, we studied the prognosis of pm. | 2000 | 11232979 |
| borrelia infection as a cause of carditis (a long-term study). | although the frequency of lyme carditis is not high, it is one of the most challenging conditions in terms of diagnosis. no long-term studies that would help expand our body of knowledge concerning the circumstances of its development and the natural course of this form of lyme borreliosis (lb), the most widespread anthropozoonosis in central europe, have been reported to date. | 2001 | 11233466 |
| [diagnosis of hyperthyroidism]. | the clinical signs and symptoms of the patient are the background for further examination procedures. a dysfunction of the thyroid gland can be safely excluded when the tsh level is within the normal range. a hyperthyroidism can be proven when tsh is suppressed and t3 and t4 levels, respectively, are elevated. however, the concentrations of t3, t4 (inclusive free t3 and free t4) and tsh are not only dependent on the thyroid status, but also on various extrathyroidal influences. therefore awarene ... | 2001 | 11233497 |
| iodine-induced hypothyroidism as a result of excessive intake of confectionery made with tangle weed, kombu, used as a low calorie food during a bulimic period in a patient with anorexia nervosa. | a 20-year-old japanese female anorectic patient developed primary hypothyroidism associated with generalized edema because of excessive daily intake (40 to 50 g) of confectionery made with tangle weed, kombu, which she substituted to food during bulimic periods; tsh 60.35 mcu/ml, free t3 1.19 pg/ml, and free t4 0.48 ng/dl, and her weight increased by 12 kg to 45 kg over 4 months. after withdrawal of kombu her thyroid function returned to normal, and her weight decreased by 7 kg to 38 kg along wi ... | 1998 | 11234256 |
| [single turnover kinetics of phage t4 dna-(n6-adenine)methyltransferase]. | interaction of t4 dna-(n6-adenine)-methyltransferase [ec 2.1.1] was studied with a variety of synthetic oligonucleotide substrates containing the native recognition site gatc or its modified variants. the data obtained in the decisecond and second intervals of the reaction course allowed for the first time the substrate methylation rates to be compared with the parameters of the steady-state reaction. it was established that the substrate reaction proceeds in two stages. because it is shown that ... | 2001 | 11234384 |
| differences in renal response between endovascular and open repair of abdominal aortic aneurysms. | to determine the difference in renal and systemic response between open and endovascular aneurysm repair. | 2001 | 11237792 |
| two types of recombination hotspots in bacteriophage t4: one requires dna damage and a replication origin and the other does not. | recombination hotspots have previously been discovered in bacteriophage t4 by two different approaches, marker rescue recombination from heavily damaged phage genomes and recombination during co-infection by two undamaged phage genomes. the phage replication origin ori(34) is located in a region that has a hotspot in both assays. to determine the relationship between the origin and the two kinds of hotspots, we generated phage carrying point mutations that should inactivate ori(34) but not affec ... | 2001 | 11238396 |
| human immunodeficiency virus type 1 central dna flap: dynamic terminal product of plus-strand displacement dna synthesis catalyzed by reverse transcriptase assisted by nucleocapsid protein. | to terminate the reverse transcription of the human immunodeficiency virus type 1 (hiv-1) genome, a final step occurs within the center of the proviral dna generating a 99-nucleotide dna flap (6). this step, catalyzed by reverse transcriptase (rt), is defined as a discrete strand displacement (sd) synthesis between the first nucleotide after the central priming (cppt) site and the final position of the central termination sequence (cts) site. using recombinant hiv-1 rt and a circular single-stra ... | 2001 | 11238856 |
| immunological inter-strain crossreactivity correlated to 18s rdna sequence types in acanthamoeba spp. | various species of the genus acanthamoeba have been described as potential pathogens; however, differentiation of acanthamoebae remains problematic. the genus has been divided into 12 18s rdna sequence types, most keratitis causing strains exhibiting sequence type t4. we recently isolated a keratitis causing acanthamoeba strain showing sequence type t6, but being morphologically identical to a t4 strain. the aim of our study was to find out, whether the 18s rdna sequence based identification cor ... | 2001 | 11239936 |
| experience with split-course external beam irradiation +/- chemotherapy and integrated ir-192 high-dose-rate brachytherapy in the treatment of primary carcinomas of the anal canal. | the effect of the treatment of anal cancer by performing a high-dose-rate (hdr) brachytherapy boost during a short split between the external beam radiotherapy series (ebr) +/- chemotherapy was investigated. | 2001 | 11240240 |
| use of impedance cardiography to monitor haemodynamic changes during laparoscopy in children. | haemodynamic changes were measured noninvasively using impedance cardiography (icg) in 30 asa i children during laparoscopic varicocelectomy under general anaesthesia. after induction and intubation, mechanical ventilation was started, then pneumoperitoneum (pp) was created. during the course of anaesthesia, values of endtidal co2 pressue (peco2), peak inspiratory airway pressure (pip), heart rate (hr), mean arterial blood pressure (mabp), stroke volume index (svi), cardiac index (ci) and system ... | 2001 | 11240875 |
| occult lymph node metastases in supraglottic cancers of the larynx. | occult cervical lymph node metastases may often be associated with cancers of the supraglottic larynx. the aims of this investigation were: (1) to determine the incidence of occult lymph node metastases in patients with cancer of the larynx; (2) to assess whether the presence of such metastases was related to the extent of the primary tumor (t) and its grading (g); and (3) to discuss which therapeutic approach should be followed in treating clinically occult lymph node metastases. our investigat ... | 2001 | 11240985 |
| induction chemoradiation and surgical resection for non-small cell lung carcinomas of the superior sulcus: initial results of southwest oncology group trial 9416 (intergroup trial 0160). | the rate of complete resection (50%) and the 5-year survival (30%) for non-small cell lung carcinomas of the superior sulcus have not changed for 40 years. recently, combined modality therapy has improved outcome in other subsets of locally advanced non-small cell lung carcinoma. this trial tested the feasibility of induction chemoradiation and surgical resection in non-small cell lung carcinoma of the superior sulcus with the ultimate aim of improving resectability and survival. | 2001 | 11241082 |
| epithelial and stromal syndecan-1 expression as predictor of outcome in patients with gastric cancer. | the prognostic value of the immunohistochemical expression of epithelial and stromal syndecan-1 was evaluated in 296 patients with gastric carcinoma. formalin-fixed, paraffin-embedded specimens of gastric adenocarcinomas were stained with mouse monoclonal antibody b-b4 against human syndecan-1. loss of immunoreactivity (syndecan-1 immunoreactivity correlated with a higher stage of disease (stages ii-iv), tumour location in the upper third of the stomach, nodal metastases (n1 or n2), positive str ... | 2001 | 11241302 |
| differential expression of catecholamine biosynthetic enzymes in the rat ventrolateral medulla. | adrenergic (c1) neurons located in the rostral ventrolateral medulla are considered a key component in the control of arterial blood pressure. classically, c1 cells have been identified by their immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (th) and/or phenylethanolamine n-methyltransferase (pnmt). however, no studies have simultaneously demonstrated the expression of aromatic l-amino acid decarboxylase (aadc) and dopamine beta-hydroxylase (dbh) in these neuron ... | 2001 | 11241375 |
| immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. | the toxin-antibody complex anti-d(beta)h-saporin (dsap) selectively destroys d(beta)h-containing catecholamine neurons. to test the role of specific catecholamine neurons in glucoregulatory feeding and adrenal medullary secretion, we injected dsap, unconjugated saporin (sap), or saline bilaterally into the paraventricular nucleus of the hypothalamus (pvh) or spinal cord (t2-t4) and subsequently tested rats for 2-deoxy-d-glucose (2dg)-induced feeding and blood glucose responses. injections of dsa ... | 2001 | 11241386 |
| prediction of thoracic kyphosis using the debrunner kyphometer. | the debrunner kyphometer is an accepted tool for detecting and evaluating thoracic kyphosis. this prospective study was conducted to create a mathematical formula that provides, with high approximation, the roentgenographic angle of thoracic kyphosis (t4-t12) using only the kyphometer. several clinical (kyphometer value, age, and sex) and radiographic (cobb angle [t4-t12]) parameters from 90 consecutively screened adolescents (44 male and 46 female) were correlated using simple and multiple line ... | 2001 | 11242276 |
| [synthesis and antifungal activities of 1-(1-substitutedphenyl)-2-(1h-1,2,4-triazol or benztriazol-1-yl)-o-(substitutedbenzyl) ethanoximes]. | twenty-nine 1-(1-substituted phenyl)-2-(1h-1,2,4-triazol or benztriazol-1-yl)-o-(substituted benzyl) ethanoximes have been synthesized for the first time. results of preliminary biological test in vitro show that most compounds have antifungal activities against most fungi tested. the antifungal activities of compounds t1, t4, t6, t11, t12, b1, b3, b4 and b6 are better than or comparable to the activities of the lead compound oxiconazole against some fungi. | 1997 | 11243218 |
| mapping the molecular interface between the sigma(70) subunit of e. coli rna polymerase and t4 asia. | bacteriophage t4 antisigma protein asia (10 kda) orchestrates a switch from the host and early viral transcription to middle viral transcription by binding to the sigma(70) subunit of e. coli rna polymerase. the molecular determinants of sigma(70)-asia complex formation are not known. here, we used combinatorial peptide chemistry, protein-protein crosslinking, and mutational analysis to study the interaction between asia and its target, the 33 amino acid residues-long sigma(70) peptide containin ... | 2001 | 11243776 |
| mid-thoracic tenderness: a comparison of pressure pain threshold between spinal regions, in asymptomatic subjects. | palpation for tenderness forms an important part of the manual therapy assessment for musculoskeletal dysfunction. in conjunction with other testing procedures it assists in establishing the clinical diagnosis. tenderness in the thoracic spine has been reported in the literature as a clinical feature in musculoskeletal conditions where pain and dysfunction are located primarily in the upper quadrant. this study aimed to establish whether pressure pain thresholds (ppts) of the mid-thoracic region ... | 2001 | 11243907 |
| substitutions in bacteriophage t4 asia and escherichia coli sigma(70) that suppress t4 mota activation mutations. | bacteriophage t4 middle-mode transcription requires two phage-encoded proteins, the mota transcription factor and asia coactivator, along with escherichia coli rna polymerase holoenzyme containing the sigma(70) subunit. a mota positive control (pc) mutant, mota-pc1, was used to select for suppressor mutations that alter other proteins in the transcription complex. separate genetic selections isolated two asia mutants (s22f and q51e) and five sigma(70) mutants (y571c, y571h, d570n, l595p, and s60 ... | 2001 | 11244069 |
| [a case of non-small-cell lung cancer with intramedullary spinal cord metastasis diagnosed pre-mortem]. | the patient was a 54-year-old man who in may 1999 received a diagnosis of squamous cell carcinoma, t4 n2 m1, stage iv. systemic chemotherapy and stereotactic radiosurgery were performed only to result in further progression of the disease. in august 1999, he experienced gait disturbance due to lumbar pain. rehabilitation improved the gait disturbance and he was discharged. in october, since the pain reappeared and there was numbness in the right leg, he was readmitted. brain mri revealed multipl ... | 2000 | 11244733 |
| relationships between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (ursus maritimus) at svalbard. | associations were determined between retinol and the thyroid hormones thyroxine (t4) and triiodothyronine (t3), respectively, and the organochlorine contaminants (ocs) polychlorinated biphenyls (pcbs), 1, 1-dichloro-2,2-bis-(4-chlorophenyl)ethylene (dde), hexachlorobenzene (hcb), and hexachlorocyclohexanes (hchs) in blood plasma from polar bears (ursus maritimus) caught at svalbard. the blood samples were collected from free-ranging polar bears of different age and sex in 1991-1994. the retinol ... | 2001 | 11245393 |
| bacillary angiomatosis: description of 13 cases reported in five reference centers for aids treatment in rio de janeiro, brazil. | the aim of this case series was to describe the clinical, laboratory and epidemiological characteristics and the presentation of bacillary angiomatosis cases (and/or parenchymal bacillary peliosis) that were identified in five public hospitals of rio de janeiro state between 1990 and 1997; these cases were compared with those previously described in the medical literature. thirteen case-patients were enrolled in the study; the median age was 39 years and all patients were male. all patients were ... | 2001 | 11246275 |
| thyroid hormone deiodination in tissues of american plaice, hippoglossoides platessoides: characterization and short-term responses to polychlorinated biphenyls (pcbs) 77 and 126. | we have described the tissue distribution and properties of thyroid hormone (th) deiodination activities of the marine american plaice, hippoglossoides platessoides. we then studied the 1- or 4-week responses of the plaice liver and brain deiodination activities and the plasma thyroxine (t4) and 3,5,3'-triiodothyronine (t3) levels to an intraperitoneal injection (5-500 ng/g) of the polychlorinated biphenyl (pcb) congeners 77 (3,3'-4,4'-tetrachlorobiphenyl) or 126 (3,3',4,4',5-pentachlorobiphenyl ... | 2000 | 11246509 |
| [use of atomic force microscopy to study the morphology and structure of viruses]. | the paper describes afm methodic approaches in the investigation of viruses (tmv, phage t4). a possibility is shown to use this method to obtain high-quality three-dimensional image of objects without additional treatment with salts of heavy metals. the phage t4 was also a model to study the object density, using the phase shift of the afm. such researches can determine the internal structure of a virion and folding of nucleic acid inside a virion. | 2000 | 11247349 |
| [radical cystectomy with ileoneocystoplasty]. | there were examined 32 patients with cancer of bladder, to whom radical cystectomy with ileoneocystoplasty in the author's modification was performed. operative intervention was done for the transitional cell carcinoma of bladder in t2-t4 stage. the method of the bladder formation using resection of the ileum segment 40-60 cm in length was adduced. the intestinal segment was transsected along the side opposite to mesentery, the transplant was placed in u-like fashion, the posterior wall of bladd ... | 2000 | 11247435 |
| combined spinal and epidural anesthesia for labor and cesarean delivery in a patient with guillain-barre syndrome. | the anesthetic management of labor, delivery, and cesarean delivery in patients with active or resolving guillain-barre syndrome is not well defined. using a combined spinal and epidural (cse) technique in such a rare clinical situation has not been previously reported. | 2001 | 11251144 |
| increased expression of s100a4 and its prognostic significance in esophageal squamous cell carcinoma. | s100a4 has been implicated in invasion and metastasis of cancer, but prognostic significance of its expression in esophageal squamous cell carcinoma remains unclear. in this study, we examined the expression of s100a4 by western blot analysis and immunohistochemistry in surgically resected esophageal squamous cell carcinoma. the relationship between s100a4 tissue status and clinicopathological findings was analyzed to assess the prognostic significance of s100a4 in esophageal squamous cell carci ... | 2001 | 11251165 |
| trimodality management of malignant pleural mesothelioma. | we reviewed our experience with trimodality management of malignant pleural mesothelioma (mpm). | 2001 | 11251277 |
| effect of excitatory amino acids on serum tsh and thyroid hormone levels in freely moving rats. | the actions of glutamate (l-glu), and glutamate receptor agonists on serum thyroid hormones (t4 and t3) and tsh levels have been studied in conscious and freely moving adult male rats. the excitatory amino acids (eaa), l-glu, n-methyl-d-aspartate (nmda), kainic acid (ka) and domoic acid (dom) were administered intraperitoneally. blood samples were collected through a cannula implanted in the rats jugular 0--60 min after injection. thyroid hormone concentrations were measured by enzyme immunoassa ... | 2000 | 11251371 |
| haematuria in africa: is the pattern changing? | to study the aetiological factors and clinical presentation of haematuria as seen in a tertiary healthcare centre in a developing country in africa. | 2001 | 11251524 |
| the x philes: structure-specific endonucleases that resolve holliday junctions. | genetic recombination is a critical cellular process that promotes evolutionary diversity, facilitates dna repair and underpins genome duplication. it entails the reciprocal exchange of single strands between homologous dna duplexes to form a four-way branched intermediate commonly referred to as the holliday junction. dna molecules interlinked in this way have to be separated in order to allow normal chromosome transmission at cell division. this resolution reaction is mediated by structure-spe ... | 2001 | 11251805 |
| gender specificity of resting anterior electroencephalographic asymmetry and defensiveness in the elderly. | it has been reported that defensiveness in women is associated with relative left-frontal electroencephalogram (eeg) activation, while defensiveness in men is associated with relative right-frontal eeg activation. the present study examined whether this result generalized to men and women between the ages of 58 and 70. | 1999 | 11252841 |
| effects of caloric restriction on skeletal muscle mitochondrial proton leak in aging rats. | long-term caloric restriction (cr) retards aging processes and increases maximum life span. we investigated the influence of cr on mitochondrial proton leaks in rat skeletal muscle. because cr lowers oxidative damage to mitochondrial membrane lipids and proteins, we hypothesized that leak would be lower in mitochondria from old cr rats than in age-matched controls. three groups (n = 12) were studied: 4-month-old "young" control rats (body weight: 404 g +/- 7 sem), 33-month-old cr rats (body weig ... | 2001 | 11253148 |
| hypothalamus-hypophysis-thyroid axis, triiodothyronine and antithyroid antibodies in patients with primary and secondary sjögren's syndrome. | it has been well established that, anti-thyroglobulin antibodies (atg) and anti-microsomal antibodies (amc) may be present in various thyroid disorders and other systemic autoimmune diseases, including sjögren's syndrome (ss). however, presence of circulating autoantibodies to thyroid hormones, i.e. both to triiodothyronine (t3) and tetraiodothyronine (t4), has not been studied extensively in ss. autoantibodies to t3 and t4 are very important, because serum t3 and t4 levels may be detected spuri ... | 2001 | 11254240 |
| genetic analysis of the t4 holin: timing and topology. | the t protein of bacteriophage t4 shares with other holins the ability to cause the formation of a lethal membrane lesion which allows the phage endolysin to attack the peptidoglycan. moreover, t, like other holins, acts in a saltatory manner at a precisely programmed time in the vegetative cycle. unlike other holins, however, t has the unique ability to postpone its lethal function in response to a secondary infection by a t-even phage during the vegetative cycle. a signal transduction system t ... | 2001 | 11255004 |
| no detectable dna excision repair in uv-exposed hepatocytes from two catfish species. | dna repair is a critical process in protecting cellular genetic information from mutation. nucleotide excision repair (ner) is a mechanism by which cells correct dna damage caused by agents that form bulky covalent adducts and uv photoproducts such as thymine dimers and 6-4 photoproduct. ner, sometimes called dark repair, is generally accepted as being low in fish compared to mammals. this study was designed to quantitate ner in two related catfish species that have known differential sensitivit ... | 2001 | 11255108 |
| expression and properties of bacteriophage t4 gene product 11. | a plasmid vector for expression of bacteriophage t4 gene product 11 (gp11) in e. coli cells has been constructed. gp11 is a baseplate protein that connects short tail fibers providing irreversible adsorption of the virus on a cell. a method based on chromatography on hydroxyapatite has been developed for purification of recombinant gp11. the protein is active in an in vitro complementation assay and transforms defective phage particles lacking gp11 into infective ones. gel filtration data sugges ... | 2001 | 11255120 |
| intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials. | preoperative radiation treatment with concomitant intravenous infusion of 5-fluorouracil (5-fu) is known to be effective in shrinking and downstaging of tumors. however, chemotherapy has often been limited by its toxicity and poor patient compliance. oral 5-fu is known to have several advantages over conventional intravenous 5-fu infusion such as lower toxicity and higher quality of life without compromising the efficacy of the treatment. the aim of this study was to compare intravenous 5-fu wit ... | 2001 | 11256837 |
| efficacy of standard ten millicurie dose of radio-iodine in management of autonomously functioning toxic thyroid nodules. | therapeutic effect of radio-iodine treatment on thyroid patients with autonomously functioning toxic thyroid nodule was evaluated. fifty one patients were given a standard dose of 10 mci of radioiodine (i-131) and were followed up for 2-3 years. the failure rate (relapse after 10 mci of radioiodine) of this regime was 10%. it was found that the nodules less than or equal to 3 cms. in size were completely cured after a dose of 10 mic. of radio-iodine therapy, over a follow up period of next 6 mon ... | 1995 | 11256900 |
| flexural strength of cerec 2 machined and jointed inceram-alumina and inceram-zirconia bars. | the flexural strength of cerec 2 inceram-alumina and inceram-zirconia bars is evaluated. the focus of the in vitro study is to identify a jointing procedure for inceram which may be used for producing full-ceramic fixed-partial-denture frameworks. | 2001 | 11257300 |
| [chemotherapy with cisplatinum, carboplatin and 5fu-folinic acid, followed by concomitant chemo-radiotherapy in unresectable esophageal carcinomas]. | the best chemotherapeutic regimen for advanced carcinoma of the esophagus remains to be determined. we have evaluated a combination of carboplatin, cisplatin and 5fu modulated by folinic acid. patients. twenty-seven patients (median age 57 yrs) with an unresectable carcinoma of the esophagus were included in this trial: 9 patients with a local relapse after surgery, 6 patients with a locally advanced (t4) tumor, and 12 patients with metastasis. treatment schedule. initial chemotherapy : carbopla ... | 2001 | 11257595 |
| [danish endocrinologists' examination and treatment of non-toxic multinodular goiter. a questionnaire study]. | to assess the attitudes towards the management of the non-toxic multinodular goitre by means of a questionnaire concerning on case history, which was circulated to all danish endocrinologists ("a 42-year-old woman with an irregular, non-tender, bilaterally enlarged thyroid of 50-80 g and no clinical suspicion of malignancy"). | 2001 | 11258250 |
| changes in serum thyroid hormone levels in newborn calves as a diagnostic index of endemic goiter. | maximum serum thyroxine (t4) and triiodothyronine (t3) levels of healthy calves were seen at 1 day after birth, and thereafter rapidly decreased until 5 days after birth. they stabilized until 2 weeks after birth, then gradually decreased until 4 weeks after birth. serum t4 levels of calves with endemic goiter tended to be lower than those of healthy ones, but showed similar levels to those of adult cows. t3 levels of calves with goiter were similar to those of healthy ones, but showed higher va ... | 2001 | 11258455 |
| introduction of an rna stability element at the 5'-end of an antisense rna cassette increases the inhibition of target rna translation. | this communication describes improvement strategies used on a previously described two-unit antisense rna cassette system. this cassette system encodes rna with noncontiguous regions of complementarity to a bacterial target rna, laci mrna. one of the units of complementarity was contained within an rna stem-loop resembling that of the very efficient, naturally occurring antisense rna copa. as relatively low inhibitory activity was obtained previously, we tested variants in which several stem-loo ... | 2001 | 11258619 |
| evaluation of health aspects of kojic acid in food. | kojic acid is a fungal metabolite commonly produced by many species of aspergillus, acetobacter, and penicillium. the aspergillus flavus group has traditionally been used in the production of a number of foods, including miso (soybean paste), shoyu (soy sauce), and sake. kojic acid is widely used as a food additive for preventing enzymatic browning, and in cosmetic preparations as a skin-lightening or bleaching agent. because kojic acid is often produced during the fermentation of historically u ... | 2001 | 11259181 |
| circannual pattern of hypothalamic-pituitary-thyroid (hpt) function and mood during extended antarctic residence. | the seasonal variation in thyroid function and mood was examined in 10 men and two women who spent the 1997 or 1998 austral winter at mcmurdo station, antarctica. serum samples of tsh, free t3 and free t4 were collected each month over a 10-month period (october-august), along with responses to the profile of mood states (poms) and the center for epidemiologic studies - depression (ces-d) scale. both tsh and mood (a summary score created from the poms depression, anger, fatigue and confusion sub ... | 2001 | 11259861 |
| influence of source and ratio of xanthophyll pigments on broiler chicken pigmentation and performance. | one experiment was conducted using 960 1-d-old, sexed broilers of ross 308 strain from 1 to 43 d to evaluate if one type of chemically isomerized marigold with 25% of xanthophylls as zeaxanthin (sme-25) could produce pigmentation equivalent to the current addition of conventional marigold with 10% of xanthophylls as zeaxanthin (sme-10) plus canthaxanthin (ctx) in practical broiler diets (maize-wheat-soybean). birds were allocated in 32 pens, in a randomized complete block design (four blocks x f ... | 2001 | 11261563 |
| [the use of bi-pedical rotatory door muscle-skin flap reconstruction in extended partial laryngectomy for late (t3 and t4) glottic cancer]. | the purpose is to radical treatment for late glottic cancer by surgery, to restore the essential function of the larynx, 62 patients of late (t3 and t4) glottic cancer were treated by extended vertical partial and subtotal laryngectomy. at the same time, an appropriate method of reconstruction of laryngeal function by bi-pedical rotatory door muscle-skin flap was presented. the decannulation rate was 87.1% and 85.0% cases enjoyed satisfactory voice. all cases resumed normal mouth-food-taking. th ... | 1998 | 11263209 |
| [speech reconstruction after laryngectomy by using modified pearson's operation]. | since 1990, 16 patients received speech reconstruction after laryngectomy by using modified pearson's operation. among them, t3, t4 laryngeal cancer 12 cases, t4 hypopharyngeal cancer 4 case, 14 were male and 2 were female, the eldest was 73 years old and the youngest 51 years old, and the average age was 58 years. in the operation, the tracheo-pharyngeal speech tube were sewn up with mucosa remained at laryngopharynx. during 1-5 years follow up, the speech function and swallow function were sat ... | 1998 | 11263212 |
| side-effects of iodized oil administration in patients with simple goiter. | the objective of this study was to determine side-effects associated with iodized oil injection in patients with simple goiter. in an iodine-deficient population, 3420 patients with simple goiter, who were not taking supplemental iodine, were chosen for this study. they received a single intramuscular injection of 1 ml iodized oil, containing 480 mg iodide. clinical and laboratory evaluations were performed every 3 months for one year and every 6 months for the next 4 years. the incidence of hyp ... | 2001 | 11263474 |
| intellectual outcome of patients with congenital hypothyroidism detected by neonatal screening. | mental retardation is a major sequela of delayed treatment for congenital hypothyroidism; congenital hypothyroidism can be treated early if detected with neonatal screening. we evaluated the intellectual outcomes of 62 patients with congenital hypothyroidism detected by neonatal screening at a major teaching hospital in northern taiwan. the effects of thyroid pathology, age at the initiation of treatment, socioeconomic status, and severity of hypothyroidism on intellectual outcome were also anal ... | 2001 | 11265259 |
| [long-term survival of a patient with postoperative liver metastasis of stage iva gallbladder cancer responding to hepatic arterial infusion chemotherapy]. | a 58-year-old man was diagnosed as having advanced gallbladder cancer (t4, p0, h0, n0, stage iva) with direct invasion to the liver, transverse colon and duodenum. therefore, extended cholecystectomy and bile duct resection with a partial resection of the transverse colon and the duodenum were performed in march 1992. histopathological examination revealed moderately differentiated tubular adenocarcinoma of si, ly1, v1, hinf3, binf3, n0. three years and eight months after the operation, multiple ... | 2001 | 11265412 |
| methylation by a mutant t2 dna [n(6)-adenine] methyltransferase expands the usage of reca-assisted endonuclease (rare) cleavage. | properties of a mutant bacteriophage t2 dna [n:(6)-adenine] methyltransferase (t2 dam mtase) have been investigated for its potential utilization in reca-assisted restriction endonuclease (rare) cleavage. steady-state kinetic analyses with oligonucleotide duplexes revealed that, compared to wild-type t4 dam, both wild-type t2 dam and mutant t2 dam p126s had a 1.5-fold higher k(cat) in methylating canonical gatc sites. additionally, t2 dam p126s showed increased efficiencies in methylation of non ... | 2001 | 11266550 |
| extended resection of locally advanced (t4) stomach cancer. | the surgical management of locally advanced (t4) stomach cancer remains controversial and many still question the benefits of an extended resection. the aims of this study were to examine the morbidity and mortality associated with extended resection and also to determine the survival benefit. | 2000 | 11269977 |
| [experience in the treatment of 98 carcinomas of the nasopharynx. long-term follow-up and analysis of prognostic factors]. | this was a retrospective study of 98 patients (pts.) with histologically confirmed nasopharyngeal carcinoma. the clinico-demographic characteristics were: median age of 53 years (11-83); 74 males and 24 females (ratio 3:1); histology subtype oms 2-3 in 89 pts. (90.8%); cranial nerve deficits in 11 pts. (11.2%); 50 (51%) were stage t3t4; 68 pts. (69.4%) n2n3 and 77 pts. (78.6%) stage iv. the therapeutic modalities were: radical radiotherapy (rt) alone in 42 pts., chemotherapy (ct) alone in 4 pts. ... | 2000 | 11270103 |
| clinical and laboratory evaluation of hyperlipemic and hypothyroid patients. | to determine the frequency of hypothyroidism in a sample of hyperlipemic patients and evaluate clinical and laboratory factors indicative of thyropathy among them. | 2001 | 11270315 |
| routine measurement of serum calcitonin is useful for early detection of medullary thyroid carcinoma in patients with nodular thyroid diseases. | medullary thyroid carcinoma (mtc) is characterized by a high concentration of serum calcitonin. routine measurement of serum calcitonin concentration has been advocated for detection of mtc among patients with nodular thyroid diseases. however, a minimal to moderate increase of serum calcitonin concentration has been frequently observed in diseases other than mtc. fine-needle aspiration cytology (fnac) is not a reliable method for detection of mtc. therefore, we evaluated the usefulness of routi ... | 2001 | 11272100 |
| early development of transient hypothyroidism after i131 therapy for thyrotoxicosis. | 295 patients of graves' disease were studied for early development of transient hypothyroidism (th) and its prognostic value following i131 therapy. 278 patients received i131 < 10 mci (6.4 +/- 1.7 mci) and 17, a dose of > 10 mci (12.6 +/- 2.6). th was diagnosed on the basis of low t4 regardless of tsh within the first year after i131 therapy followed by normal t4 and tsh. 32 patients developed th following administration of < 10 mci i131 and it was symptomatic in 10 patients. no instance of th ... | 1998 | 11273344 |
| stress response in infants undergoing cardiac surgery: a randomized study of fentanyl bolus, fentanyl infusion, and fentanyl-midazolam infusion. | there have been significant changes in the management of neonates and infants undergoing cardiac surgery in the past decade. we have evaluated in this prospective, randomized, double-blinded study the effect of large-dose fentanyl anesthesia, with or without midazolam, on stress responses and outcome. forty-five patients < 6 mo of age received bolus fentanyl (group 1), fentanyl by continuous infusion (group 2), or fentanyl-midazolam infusion (group 3). epinephrine, norepinephrine, cortisol, adre ... | 2001 | 11273919 |
| computational method to reduce the search space for directed protein evolution. | we introduce a computational method to optimize the in vitro evolution of proteins. simulating evolution with a simple model that statistically describes the fitness landscape, we find that beneficial mutations tend to occur at amino acid positions that are tolerant to substitutions, in the limit of small libraries and low mutation rates. we transform this observation into a design strategy by applying mean-field theory to a structure-based computational model to calculate each residue's structu ... | 2001 | 11274394 |
| effects of transient neonatal hyperthyrotropinemia on intellectual quotient and psychomotor performance. | transient neonatal hyperthyrotropinemia (tnh) occurs frequently in areas of iodine deficiency. to evaluate the effect of tnh in intellectual function and psychomotor performance, a historical cohohrt study was performed in 9 years old children with documented tnh at birth. 18 children with tnh who had been born in mahdieh hospital were studied at age 9 and compared to 19 matcheal children born at the same time, but having normal thyroid function at birth. global intelligence (iq) and psychomotor ... | 2001 | 11276926 |
| the escherichia coli rna polymerase.anti-sigma 70 asia complex utilizes alpha-carboxyl-terminal domain upstream promoter contacts to transcribe from a -10/-35 promoter. | during infection of escherichia coli, the phage t4 early protein asia inhibits open complex formation by the rna polymerase holoenzyme efinal sigma(70) at -10/-35 bacterial promoters through binding to region 4.2 of the final sigma(70) subunit. we used the -10/-35 lacuv5 promoter to study the properties of the efinal sigma(70). asia complex in the presence of the glutamate anion. under these experimental conditions, inhibition by asia was significantly decreased. kmno(4) probing showed that the ... | 2001 | 11278617 |
| evidence for a functional monomeric form of the bacteriophage t4 dda helicase. dda does not form stable oligomeric structures. | the active form of many helicases is oligomeric, possibly because oligomerization provides multiple dna binding sites needed for unwinding of dna. in order to understand the mechanism of the bacteriophage t4 dda helicase, the potential requirement for oligomerization was investigated. chemical cross-linking and high pressure gel filtration chromatography provided little evidence for the formation of an oligomeric species. the specific activity for ssdna stimulated atpase activity was independent ... | 2001 | 11278788 |
| neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats. | spinal cord transection (sct) delays gastric emptying (ge), and intestinal and gastrointestinal (gi) transit of liquid in awake rats. this study evaluates the neural mechanisms involved in this phenomenon. male wistar rats (n = 147) were fasted for 16 h and had the left jugular vein cannulated followed by laminectomy or laminectomy + complete sct between t4 and t5 vertebrae. the next day, a test meal (1.5 ml of a phenol red solution, 0.5 mg/ml in 5% glucose) was administered by gavage feeding an ... | 2001 | 11280307 |
| prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an italian multicenter study. | many afflictions have been associated with celiac disease, but chance associations may exists. the aim of this study was to establish, by means of a multicenter prospective study, the prevalence of thyroid impairment among adult patients with newly diagnosed celiac disease and to evaluate the effect of a 1-yr gluten withdrawal on thyroid function. | 2001 | 11280546 |
| influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial. | to investigate whether early selenium (se) supplementation can modify the post-traumatic alterations of thyroid hormone metabolism, since the first week after trauma is characterised by low plasma se and negative se balances. | 2001 | 11280679 |
| inhibition of t3 production in levothyroxine-treated female mice by the root extract of convolvulus pluricaulis. | an investigation was made to evaluate the role of convolvulus pluricaulis root extract in the regulation of hyperthyroidism in female mice. its possible site of action was also studied. l-thyroxine treatment for 30 days increased serum concentrations of thyroxine (t4) and triodothyronine (t3). the activity of hepatic 5'-monodeiodinase (5'-di) and glucose-6-phosphatase (g-6-pase) was also enhanced. on the other hand, administration of the plant extract either alone or with l-t4, decreased serum t ... | 2001 | 11280709 |
| impact of high-flux/high-efficiency dialysis on folate and homocysteine metabolism. | high-flux/high-efficiency (hf/he) dialysis may have detrimental effects on micro-nutrients and water-soluble vitamins, such as vitamin b6, whose levels are lowered. folate deficiency may increase cardiovascular risk through an increase in homocysteine (hcy) serum levels. we therefore investigated the effects of dialysis with a high-flux (hf) membrane on folate and hcy metabolism. twelve patients without any folate supplementation, receiving dialysis with a low-flux membrane prior to the study (t ... | 2001 | 11281342 |
| serum thyroid-stimulating-hormone concentration as an index of severity of major depression. | alterations in thyroid axis are common in depression and subclinical hypothyroidism may predispose to recurrent depressive episodes and resistance to antidepressants. the same normal reference ranges are used in both depressive and non-psychiatric patients to detect hypothyroidism. we hypothesized that in depressive patients, serum tsh (thyrotropin) elevation within the normal reference range (>/= upper 25th percentile) may be related to patients' characteristics reflecting the severity of the d ... | 1999 | 11281977 |
| uncoupling protein1 mrna, mitochondrial gtp-binding, and t4 5'-deiodinase of brown adipose tissue in euthermic daurian ground squirrel during cold exposure. | regulation of thermogenic activity and uncoupling protein1 (ucp1) expression in brown adipose tissue (bat) were studied in euthermic daurian ground squirrel after acute and chronic cold exposure at 4 degrees c. the ucp1 concentration was indirectly determined by titration with its specific ligand [3h]-labeled gtp, and ucp1 mrna was detected by using a [32p]-labeled antisense oligonucleotide probe. both acute and chronic cold exposure stimulated up-regulation of ucp1 mrna. although ucp1 concentra ... | 2001 | 11282325 |
| transcriptional regulation at a distance in bacteria. | transcriptional enhancers are cis-acting dna elements that are binding sites for regulatory proteins and function at large distances from promoter elements to stimulate transcription. once thought to be unique to eukaryotes, enhancer-like elements have been discovered in a wide variety of bacteria. the regulatory proteins that bind to these bacterial enhancers must contact rna polymerase to activate transcription. in principle, interactions between bacterial enhancer-binding proteins and rna pol ... | 2001 | 11282468 |
| uvsw protein regulates bacteriophage t4 origin-dependent replication by unwinding r-loops. | the uvsw protein of bacteriophage t4 is involved in many aspects of phage dna metabolism, including repair, recombination, and recombination-dependent replication. uvsw has also been implicated in the repression of origin-dependent replication at late times of infection, when uvsw is normally synthesized. two well-characterized t4 origins, ori(uvsy) and ori(34), are believed to initiate replication through an r-loop mechanism. here we provide both in vivo and in vitro evidence that uvsw is an rn ... | 2001 | 11283250 |
| [endocrinology 1999-2000]. | long-lasting problem on the differentiation of adenohypophyseal cell, which prepares them for their specific tasks (somatotropic, lactotropic ect.), becomes elucidated after recognition of the differentiational effect of transcription factor pit-1. expression of that factor in somatotrops results in sth secretion, contrary to lactotrops producing prolactin. subclinical hypothyreosis (increased tsh with normal t3 and t4) endangers vessel not because of hypercholesterolemia, but because of changes ... | 2001 | 11284421 |
| solution structure of the transcriptional activation domain of the bacteriophage t4 protein, mota. | bacteriophage t4 encodes a transcription factor, mota, that binds to the -30 region of middle-mode promoters and activates transcription by host rna polymerase. the crystal structure of the n-terminal domain of mota (motnf) revealed a six-helix domain in which the two c-terminal alpha-helices mediate the formation of a dimer via a coiled-coil motif and hydrophobic interactions. this structure suggested that full-length mota binds dna as a dimer, but subsequent biochemical results have shown that ... | 2001 | 11284685 |
| molecular mechanisms of the functional coupling of the helicase (gp41) and polymerase (gp43) of bacteriophage t4 within the dna replication fork. | processive strand-displacement dna synthesis with the t4 replication system requires functional "coupling" between the dna polymerase (gp43) and the helicase (gp41). to define the physical basis of this functional coupling, we have used analytical ultracentrifugation to show that gp43 is a monomeric species at physiological protein concentrations and that gp41 and gp43 do not physically interact in the absence of dna, suggesting that the functional coupling between gp41 and gp43 depends signific ... | 2001 | 11284703 |
| computer-assisted assessment of spinal sagittal plane radiographs. | the sagittal shape of the spine, particularly its sagittal balance, currently is being extensively investigated. the major purpose of this study is to examine the measurement repeatability of spineview software, which calculates 13 independent variables, to shorten and facilitate the measurement of lateral spinal radiographs; another purpose is to collect physiological data for nonpathologic spines, which can be used as a reference in future research. this article also presents two new parameter ... | 2001 | 11285426 |
| endoscopic clipping in video-assisted thoracoscopic sympathetic blockade for axillary hyperhidrosis. an analysis of 26 cases. | endoscopic thoracic sympathectomy or sympathicotomy is the standard method for the treatment of axillary hyperhidrosis. but postoperative compensatory sweating may be troublesome in some patients. therefore, we use endoclips to perform the t3 and t4 sympathetic blockade instead of permanently interrupting the transmission of nerve impulses from the sympathetic trunk. | 2001 | 11285952 |
| cognitive function and neurophysiological evaluation in early-treated hypothyroid children. | in this study, we assessed cognitive function and neurophysiological development in congenitally hypothyroid (ch) children. we performed a cross-sectional study at the outpatient pediatric clinic and department of neurophysiology at san raffaele hospital, milan. the study enrolled 25 ch patients (6.00-10.83 years of age) detected by neonatal screening, and 34 healthy control children (4-11 years of age). patients and controls had comparable scores at neuropsychological tests (wisc-r), and at aud ... | 2000 | 11286043 |
| genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage t4 fibritin. | the utility of adenovirus (ad) vectors for gene therapy is restricted by their inability to selectively transduce disease-affected tissues. this limitation may be overcome by the derivation of vectors capable of interacting with receptors specifically expressed in the target tissue. previous attempts to alter ad tropism by genetic modification of the ad fiber have had limited success due to structural conflicts between the fiber and the targeting ligand. here we present a strategy to derive an a ... | 2001 | 11287567 |
| effect of glutathione (gsh) depletion on the serum levels of triiodothyronine (t3), thyroxine (t4), and t3/t4 ratio in allyl alcohol-treated male rats and possible protection with zinc. | the current study is an attempt to elucidate the link between glutathione (gsh) as a major endogenous antioxidant and the thyroid hormone levels. rats were treated with a single intraperitoneal (ip) dose of either zncl2 (5 mg/kg) or allyl alcohol (aiai) (1.5 mmol/kg), which acts as a gsh-depleting agent. zncl2 and aiai were administered either alone (zn- and alal-treated groups) or in combination (aiai + zn-treated group). blood and liver samples were collected 5 hours post treatment in all grou ... | 2001 | 11288928 |
| identification of thyroglobulin in orbital tissues of patients with thyroid-associated ophthalmopathy. | thyroid-associated ophthalmopathy (tao) is thought to have an autoimmune pathogenesis because of its association with autoimmune thyroid disease, in particular with graves' disease. nevertheless, the nature of the autoimmune reaction is unclear, and a target orbital autoantigen has not been conclusively identified. a widely discussed hypothesis is that antigens constitutively shared by the thyroid and orbital tissues are targets of an autoimmune reaction. it has been also postulated that a thyro ... | 2001 | 11288989 |
| dukes b colorectal cancer: distinct genetic categories and clinical outcome based on proximal or distal tumor location. | the aim of this study was to determine whether tumor location proximal or distal to the splenic flexure is associated with distinct molecular patterns and can predict clinical outcome in a homogeneous group of patients with dukes b (t3-t4, n0, m0) colorectal cancer. it has been hypothesized that proximal and distal colorectal cancer may arise through different pathogenetic mechanisms. although p53 and ki-ras gene mutations occur frequently in distal tumors, another form of genomic instability as ... | 2001 | 11289282 |
| effect of topically applied t4 endonuclease v in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. xeroderma pigmentosum study group. | in patients with xeroderma pigmentosum the frequency of all forms of skin cancer is higher than in the general population, owing to a genetic defect in dna repair. the bacterial dna repair enzyme, t4 endonuclease v, delivered intracellularly, increases the rate of repair of sunlight-induced dna damage in human cells. we tested the ability of this enzyme in a liposomal delivery vehicle applied topically (t4n5 liposome lotion) to lower the rate of new skin cancers in patients with xeroderma pigmen ... | 2001 | 11289350 |