Publications

changes in lysosomal enzymes of peritoneal exudate cells in albino rats and mastomys natalensis during plasmodium berghei infection.	activities of certain lysosomal enzymes of peritoneal exudate cells were followed during plasmodium berghei infection in two experimental hosts. in albino rats, where sterile immunity against the infection develops, levels of beta-d-glucuroniodase and acid phosphatase activities were increased several times the normal values. on the other hand, in mastomys natalensis, which succumbs to infection, levels of both the enzymes decreased considerably. cathepsin d activity did not change to a signific ...	1980	7003382
characterization of surface proteins and glycoproteins on red blood cells from mice infected with haemosporidia: plasmodium berghei infections of balb/c mice.	the surface proteins and glycoproteins of red cells from plasmodium berghei-infected blood have been radio-isotope labelled and compared with those of normal mouse erythrocytes using the following protein labelling probes: lactoperoxidase-catalysed radio-iodination of tyrosyl residues, periodate oxidation and nab3h4 reduction of sialic acid and oxidation of galactosyl/n-acetylgalactosaminyl residues by galactose oxidase with subsequent nab3h4 reduction. during p. berghei infection, new tyrosyl-l ...	1980	7003500
complement-mediated defect in clearance and sequestration of sensitized, autologous erythrocytes in rodent malaria.	we investigated the ability of malaria-infected and normal mice to clear particulate immune complexes consisting of autologous erythrocytes sensitized with either igg or complement. normal mice rapidly clear autologous erythrocytes optimally sensitized with igg and the liver plays a major role in their sequestration. clearance of optimally sensitized erythrocytes is complement-dependent because cobra venom factor-treated, normal mice failed to clear these cells rapidly, unless they had been pre- ...	1981	7005263
antimalarials. 12. preparation of carbon isosteres of selected 4-pyridinemethanols as suppressive antimalarials.	four carbon isosteres related to the highly active 4-pyridylcarbinolamines were prepared and evaluated for suppressive antimalarial activity against plasmodium berghei in mice. three of the four examples possessed significant activity but were approximately one dose level less active than the corresponding pyridines.	1980	7005445
primaquine liposomes in the chemotherapy of experimental murine malaria.		1980	7006530
the antimalarial activity of n-benzyloxydihydrotriazines. i. the activity of clociguanil (brl 50216) against rodent malaria, and studies on its mode of action.		1980	7006531
plasmodium berghei: the in vitro immune response.		1981	7007068
evaluation of plasmodium berghei for endotoxin by the limulus lysate assay.		1980	7007601
autocytotoxins during rodent malaria.		1980	7007602
action of chymotrypsin on experimental plasmodium berghei infection in albino mice.		1980	7008478
selection of a sulphanilamide resistant strain of plasmodium berghei.		1980	7009422
permethyl analogue of the pyrrolic antibiotic distamycin a.	the synthesis of an analogue of distamycin a, a pyrrolic oligopeptide possessing antiviral and antibiotic activity, is described in which each of the three pyrrole rings is fully methylated. this structural modification results in pyrrole rings which are extraordinarily electron rich and required the development of a new synthetic approach to these polypyrrolic amides. the key reactions involved development of a general method for the synthesis of 3-aminopyrroles and for formation of an amide bo ...	1981	7009865
synthesis and antimalarial effects of n2-aryl-n4-[(dialkylamino)alkyl]- and n4-aryl-n2-[(dialkylamino)alkyl]-2,4-quinazolinediamines.	a series of n2(and n4)-aryl-n4(and n2)-[(dialkylamino)alkyl]-2,4-quinazolinediamines has been synthesized for antimalarial evaluation. condensation of the appropriate 2,4-dichloroquinazoline (iv) with the requisite n,n-dialkylalkylenediamine afforded a series of 2-chloro-n-[(dialkylamino)alkyl]-4-quinazolinamines (v) which were condensed with the appropriate arylamine to provide the corresponding n2-aryl-n4-[(dialkylamino)alkyl]-2,4-quinazolinediamines (vi). hydrolysis of 2,4-dichloroquinazoline ...	1981	7009867
folate antagonists. 18. synthesis and antimalarial effects of n6-(arylmethyl)-n6-methyl-2,4,6-pteridinetriamines and related n6,n6-disubstituted 2,4,6-pteridinetriamines.	n6-(arylmethyl)-n6-methyl-2,4,6-pteridinetriamines (1-15) and related n6-substituted 2,4,6-pteridinetriamines (16-20) were obtained by the condensation of 6-chloro-2,4-pteridinediamine with n-methylarylmethanamine and other selected secondary amines. the requisite n-methylarylmethanamines (21-32) were prepared by the hydrogenation over pt/c of the corresponding arylcarboxaldehyde in the presence of methanamine. several of the n6-(arylmethyl)-n6-methyl-2,4,6-pteridinetriamines exhibited exception ...	1981	7009868
[combined effect of chloroquine and quinine in rodent malaria (plasmodium berghei)].		1980	7010106
vaccines against parasitic diseases - malaria.		1980	7010373
a genetic study of the susceptibility of anopheles gambiae to plasmodium berghei.	in a study of the genetics of susceptibility and refractoriness of anopheles gambiae to plasmodium species, nine generations of selection resulted in a completely susceptible line and an entirely refractory line to plasmodium berghei (a rodent malaria). the f1 progeny from reciprocal crosses between the lines differed in their susceptibility to the parasite. backcrosses to the parent did not produce proportions of susceptible and refractory individuals consistent with single gene inheritance or ...	1980	7010688
[some patterns of the in vivo plasmodium berghei entry into erythrocytes as revealed by scanning electron microscopy (author's transl)].		1981	7011156
quantification of hyperbaric oxygen-induced toxicity utilizing a malarial system.	this study was undertaken in recognition of the need to develop quantitative systems to evaluate the toxicity associated with hyperbaric oxygen (hbo) exposure. malaria-infected (p. berghei berghei) mice were briefly exposed to 100% oxygen at 3 ata on day 10 of infection. at 25, 48, and 72 h thereafter, the levels of circulating erythrcytes and percent parasitized rbc were monitored and compared to those of infected non-exposed controls. the total erythrocyte counts of the infected hbo-exposed an ...	1981	7011300
immunopathological aspects of plasmodium berghei infection in five strains of mice. i. immune complexes and other serological features during the infection.	the development of circulating immune complexes was studied in mice of the balb/c, a/j, of1, cba and c57b1 strains infected with p. berghei. complexes were evaluated in relation to levels of parasitaemia, soluble antigen, specific antibody and c3. susceptibility to infection was greatest in balb/c, a/j and of/a mice. the maximum parasitaemia was 30% in cba and 70% in all other strains. levels of soluble antigen paralleled those of parasitaemia. specific antibody was detected in all strains, but ...	1980	7011606
immunopathological aspects of plasmodium berghei infection in five strains of mice. ii. immunopathology of cerebral and other tissue lesions during the infection.	histological changes during the course of p. berghei infection were investigated in a/j, balb/c, of1, cba and c57b1 mice. the findings were studied in relation to serological aspects (contreras et al., 1980). high mortality and acute deaths occurred in a/j, balb/c and of1 mice and marked cerebral lesions were found in these strains from day 15, including congestion of meningeal and cerebral veins and capillaries, blocking of these vessels by heavily parasitized rbc, cerebral oedema and haemorrha ...	1980	7011607
two distinct types of non-specific immunosuppression in murine malaria.	a comparative study of non-specific immunosuppression by malaria has been carried out in five situations: in both unvaccinated and vaccinated mice infected with the lethal plasmodium yoelii or the lethal plasmodium berghei, and in the unvaccinated non-lethal p. yoelii infection. spleen cells showed a suppressive effect on the normal blastogenic response to mitogens. this suppression was strongest in the mice vaccinated before infection with the lethal p. yoelii and in those infected with non-let ...	1980	7011609
host defenses in murine malaria: failure of vaccination with formolized blood parasites to protect athymic mice from plasmodium berghei.	the thymus dependency of immunity to erythrocytic plasmodium berghei (nyu-2) infection generated in response to injections of formalin-killed mixed blood parasites was shown by the demonstration that the vaccine protected immunologically intact nu/+ mice, but not their athymic nu/nu littermates.	1980	7011989
host defenses in murine malaria: analysis of plasmodial infection-caused defects in macrophage microbicidal capacities.	macrophage-dependent killing of facultative intracellular bacteria was markedly impaired by overt erythrocytic plasmodium yoelii or plasmodium berghei infection of mice. p. yoelii infection was capable of ablating not only the macrophage microbicidal capacity of "normal" animals but also the bactericidal capacities of "activated" macrophages. the uptake by spleen and liver of an intravenous challenge of listeria monocytogenes was not altered by plasmodial infection, but within hours of injection ...	1981	7012000
effect of route of mycobacterium bovis bcg administration on induction of suppression of sporozoite immunity in rodent malaria.	intravenous immunization of mice with 16,000, 60co--gamma-irradiated, attenuated sporozoites produced solid immunity to sporozoite-induced malaria when the mice were challenged 21 days after immunization. in contrast, mice injected by various routes with 10(7) viable units of mycobacterium bovis (bcg) before immunization with irradiated sporozoites were not completely immune to challenge. the extent of reduced protection against viable sporozoites demonstrated with these animals was dependent up ...	1981	7012001
complement does not facilitate plasmodial infections.	the influence of the complement (c) system on plasmodial infections in vivo (plasmodium berghei in rats) and in vitro (plasmodium falciparum) has been determined. in rats c3 depletion by treatment of animals with the c3 inactivator isolated from cobra venom factor results in infection that develops more rapidly, reaches a higher peak of parasitemia and is associated with an increased mortality rate (60%), in contrast to a lower degree of parasitemia and lack of mortality in c3-intact rats. the i ...	1981	7012239
an ultrastructural study of developing stages of exo-erythrocytic plasmodium berghei in rat hepatocytes.	the ultrastructure of immature exo-erythrocytic forms of plasmodium berghei in rat hepatocytes was studied at stages between 25 and 51 h of development. a new method was successfully applied to localize the parasites in a small portion of the liver by temporary ligature of blood vessels to the majority of the liver, and from the spleen and the pancreas. nuclear profiles appeared to be part of a highly lobed nuclear reticulum. peripheral vesiculation and vacuolization of the cytoplasm was increas ...	1981	7012764
plasmodium berghei: glycolytic enzymes of the infected mouse erythrocyte.		1981	7014240
role of spleen in morbidity and mortality of plasmodium berghei infection in mice.	splenectomy has a strain-specific effect on plasmodium berghei infection in mice. mean survival time either was unchanged or increased to three times the value observed in intact controls. a delay of early mortality, which was otherwise observed in the second week of infection, was a general feature of susceptible strains. delayed mortality was also observed when splenectomy was performed shortly before expected mortality. ineffectiveness of splenectomy as to increased survival time was independ ...	1980	7014442
relationship of alterations in splenic clearance function and microcirculation to host defense in acute rodent malaria.	during the course of plasmodium berghei malaria in the rat, splenic clearance of damaged uninfected erythrocytes (heated or heinz body-containing) underwent changes strikingly similar to those of infected erythrocytes. splenic trapping of abnormal erythrocytes was impaired during the period of rising parasitemia but became supernormal just before the onset of resolution of the acute infection. these changes could be related to the development of splenomegaly and alterations in splenic cordal mic ...	1981	7014635
[synthesis and study of the acute toxicity and antiparasitic activity on 6-nitro (amino)-4-dialkylaminoalkylaminoquinolines].		1981	7015098
active immunization and passive transfer of resistance against sporozoite-induced malaria in infant mice.		1981	7015150
pregnancy associated recrudescence in murine malaria (plasmodium berghei).	depending on the strain, a variable proportion of mice solidly immune to the rodent malaria parasite plasmodium berghei developed a recrudescence during pregnancy that was either transient or lethal. recrudescence was not observed in all mice, and the rate was lower in gravida ii as compared to gravida i mice. on the other hand a proportion of the mice that did not develop recrudescence exhibited a pregnancy associated clearance of persisting parasites in immune mice (premunition-sterile immunit ...	1980	7015633
plasmodium berghei: glycolytic intermediate concentrations of the infected mouse erythrocyte.		1981	7016570
[scanning electron microscopy study of initiation by plasmodium berghei of "metabolic windows" in the surface of parasitized erythrocytes (author's transl)].		1981	7018346
sequestration of the chloroquine receptor in cell-free preparations of erythrocytes infected with plasmodium berghei.	when mouse erythrocytes infected with plasmodium berghei were preincubated with [14c]chloroquine and then lysed by hypotonic shock, chloroquine remained bound to the resulting cell-free preparation. in an isotonic medium at ph 7.4 and 25 degrees c, chloroquine was bound to the cell-free preparation with an apparent dissociation constant of 1.8 x 10(-7) m. the bound [14c]chloroquine could be displaced by nonradioactive chloroquine, amodiaquine, quinacrine, and mefloquine, as would be predicted fr ...	1981	7018392
glucan-enhanced immunogenicity of killed erythrocyte stages of plasmodium berghei.	intravenous injections of glucan simultaneously with formalin-killed erythrocytic stages of plasmodium berghei elicited a greater degree of resistance in mice against subsequent infection with viable parasites than injections of killed erythrocytic stages alone. in two experiments with p. berghei strain nk 65, 100% of mice immunized with the glucan-dead parasite preparation survived challenge, whereas only 28.6% of mice receiving dead parasites alone survived. in the third experiment, using p. b ...	1981	7019074
erythrocyte destruction and protective immunity to malaria: enhancement of the immune response by phenylhydrazine treatment.	malaria infection is characterized by extensive destruction of erythrocytes. in addition, the surface membrane of parasitized erythrocytes becomes biochemically and antigenically modified. thus during infection the host immune system is exposed to massive amounts of modified erythrocytes on a scale not normally considered in conventional immunological experiments. the haemocytoxic drug phenylhydrazine hydrochloride has been used to mimic, in otherwise normal animals, the effect of the modificati ...	1981	7020185
the effect of cryopreservation on gametocytogenesis of plasmodium berghei berghei: a preliminary report.		1980	7020321
effect of plasmodium berghei on membranes of murine erythrocytes.	membranes from normal and plasmodium berghei-infected mice were analyzed to determine: 1) if any antigenic changes were present; and 2) the nature of these changes. polyacrylamide gel electrophoresis (page), immunological and biochemical analyses were performed on whole ghosts and glycoprotein fractions extracted from whole ghosts by chloroform-methanol. page profiles and biochemical analyses revealed quantitative, but not qualitative, differences between membrane proteins and glycoproteins of n ...	1981	7020448
host defenses in murine malaria: nonspecific resistance to plasmodium berghei generated in response to mycobacterium bovis infection or corynebacterium parvum stimulation.	infection with mycobacterium bovis (bcg) or injection of killed corynebacterium parvum protected some strain b6d2 f1 (c57bl/6xdba/2) mice but did not protect strain icr or a mice from lethal challenge with plasmodium berghei strain nyu-2. b6d2 mice were not protected against challenges delivered immediately after intravenous injection of these materials, but rather protection developed by day 7 and persisted through at least day 84. infections in protected mice progressed to about 10% parasitemi ...	1981	7021424
endotoxin-induced serum factor kills malarial parasites in vitro.	we investigated the possibility that malarial parasites may be killed by nonspecific soluble mediators, such as those in tumor necrosis serum, that are obtained from mice given macrophage-activating agents like corynebacterium parvum or mycobacterium bovis bcg, followed by endotoxin. such sera killed parasites in vitro after overnight incubation; killing was measured directly by using an in vivo infectivity assay. parasite infectivity was not decreased by incubation in sera from mice given c. pa ...	1981	7021427
autoantibodies to red blood cells in rats infected with plasmodium berghei.	a radio-iodinated protein a (125spa) binding assay was used to identify autoantibodies to red blood cells (rbc's) in sera of rats infected with plasmodium berghei. sera taken from rats at various times after infection were reacted with washed, normal rbc's, then the rbc's were washed and treated with 125spa. the bound radioactivity was taken as a measure of the amount of ig attached to the rbc's membranes. using this test, anti-rbc autoantibodies were detected in rat sera as early as 5 days afte ...	1981	7021787
in vitro cultivation of the exoerythrocytic stage of plasmodium berghei from sporozoites.	when inoculated with sporozoites of plasmodium berghei, the human embryonic lung cell line wi38 supports the complete asexual developmental cycle of the exoerythrocytic stage. cultured parasites were sensitive to primaquine, were shown to resemble parasites in living hosts by immunofluorescent antibody tests, and on subinoculation into mice induced a red blood cell infection, the gametocytes of which produced sporozoites in anopheline mosquitoes.	1981	7022652
babesia rodhaini and plasmodium berghei. a highly active series of chlorophenoxyalkoxy-substituted diamino-dihydrotriazines against experimental infections in mice.		1981	7023398
chloroquine resistant malaria: association with enhanced plasmodial protease activity.		1981	7023481
plasmodium berghei: effect of carrageenan on the course of infection of the a/j mouse.		1981	7024158
[general characteristics of the chemotherapeutic properties of a new experimental antimalarial preparation dabequin].		1981	7024771
[hemostatic system disorders in malaria (a review of the literature)].		1981	7024773
[search for new antimalarial compounds (a review of patents)].		1981	7024774
adoptive transfer of immunity to plasmodium berghei after busulfan and cyclophosphamide treatment of recipient mice.	balb/c mice injected with p. berghei die about 21 days after infection. successful cell transfer in mice was made possible by the pretreatment of the recipient with a combination of busulfan and cyclophosphamide. cell counts showed that drug-treated mice contain 20 times less bone marrow cells than normal mice, and when injected with p. berghei die significantly later than normal controls. the animals were injected with normal (nbm) and immune bone marrow and normal (nsp) and immune spleen (isp) ...	1981	7025493
[complex morphologic modifications observed on the surface of red blood cells parasitized by plasmodium berghei (1)].		1981	7025979
blood schizontocidal activity of antibiotics against plasmodium berghei sensitive as well as resistant to chloroquine, pyrimethamine and primaquine.		1981	7026431
biosynthesis of pb44, the protective antigen of sporozoites of plasmodium berghei.	in a previous paper (2) we identified a protective antigen (pb44) of the surface membrane of sporozoites of plasmodium berghei by means of a monoclonal antibody. immunoprecipitation of extracts of mature salivary gland sporozoites, metabolically labeled with l[35s]methionine using the same monoclonal antibody, revealed three specific polypeptides: pb44, pb52, and pb54. metabolically labeled pb44 is probably identical to the protective antigen previously identified by surface labeling. both p ...	1981	7026723
chloroquine resistant p. berghei: association with variation in plasmodial protease activity.		1981	7027269
hemin lyses malaria parasites.	malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin ix chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. this effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. the toxicity of the chloroquine-hemin complex may explain the selective antimalarial action o ...	1981	7027441
[oxidative and antioxidative system of the blood in mechanisms of erythrocyte protection and damage upon invasion by plasmodium berghei].	in the course of experimental infection with pl. berghei, the mice demonstrated an abrupt lowering in the activity of blood enzymes (superoxide dismutase and glutathione peroxidase) and a rise in the concentration of the lipid peroxidation product (malonic dialdehyde) with the growth of parasitemia. the evidence obtained are discussed in the light of the defence and injury blood mechanisms of red cell membranes.	1981	7028174
immunosuppression in murine malaria: a soluble immunosuppressive factor derived from plasmodium berghei-infected blood.	mice infected with plasmodium berghei have a depressed immune response to a variety of antigens. we report the extraction, purification, and characterization of a soluble immunosuppressive substance derived from p. berghei-infected mouse blood. a crude extract, prepared by solubilization of infected erythrocytes in a parr cell disruption bomb, reduced the anti-dnp pfc response of mice injected with the extract 1 day before immunization. purification of the immunosuppressant was accomplished by p ...	1981	7028864
treatment of rodent malaria with levamisole.		1981	7028880
malarial antibodies and parasitaemias in immunosuppressed mice.		1981	7028884
atypical reticulocytes in rats with malaria as a possible consequence of the pitting function of the spleen.		1981	7030237
synthesis of some novel amodiaquine analogues as potential antimalarial and antifilarial compounds.	ten amodiaquine analogues, which are hybridized molecules of amodiaquine and diethylcarbamazine, were designed and synthesized. six analogues, all bearing a basic tertiary amino function at their side chain, were active against plasmodium berghei in mice and inhibited the mobility of adult worms and microfilariae of breinlia booliati in vitro. they were inactive against litomosoides carinii in mastomys natalensis. the most active antimalarial compound, 7-chloro-4-[alpha-[[n-(4-methyl-1-piperazin ...	1981	7031248
studies on the infectivity of plasmodium berghei sporozoites in experimental hosts.		1981	7032427
sustained-release implants in the chemotherapy of experimental rodent malaria i. a comparison of the effects of some antimalarials in polydimethylsiloxane matrices.		1981	7032430
sustained-release implants in the chemotherapy of experimental rodent malaria ii. the effects of sulphadiazine, pyrimethamine and cycloguanil in biodegradable polymer matrices.		1981	7032431
leishmania donovani, plasmodium berghei, trypanosoma rhodesiense: antiprotozoal effects of some amidine types.		1981	7032963
[synthesis of benzo(g)quinoline derivatives. xv. di[benzo(g)-quinolylpiperazinyl]alkanes possessing antimalarial activity].		1981	7033752
[erythrocyte enzymes at different stages of plasmodium berghei schizogony].		1981	7033753
dietary suppression of rodent malaria.		1981	7034320
[morphological incidences of plasmodium berghei preference for reticulocytes (author's transl)].		1981	7034621
role of a serum factor in enhancement of in vitro interactions between plasmodium berghei sporozoites and hamster peritoneal macrophages.	interactions between plasmodium berghei sporozoites and hamster peritoneal macrophages were studied. hamster serum was shown to enhance the percentage of sporozoites tha attached to macrophages, thus confirming previous studies by other workers using mouse macrophages and mouse serum. the enhancement factor within hamster serum was concentrated by a fractionation procedure consisting of ammonium sulfate precipitation followed by concanavalin a-sepharose affinity chromatography. this serum fracti ...	1981	7035641
syntheses of 9-acridine- and 2-phenanthridinemethanols as potential antimalarials.	alpha-(1-piperidinylmethyl)-9-acridinemethanol (3), alpha-[(dibutylamino)ethyl]-9-acridanmethanol (4a), and alpha-[(dibutylamino)methyl]-2-phenanthridinemethanol (5) have been made and all are ineffective as antimalarials against plasmodium berghei in mice. 9-acridinyloxirane showed no significant mutagenicity for strains ta 98 or ta 100 of salmonella typhimurium.	1981	7035667
the binding of antibodies from plasmodium berghei-infected rats to isoantigenic and parasite-specific antigenic sites on the surfaces of infected reticulocytes.	ferritin-labelling techniques at the ultrastructural level have shown that antiserum from august rats immune to p. berghei infection contains antibodies which bind to the surfaces of parasitized reticulocytes but not to uninfected cells. two antibody specificities have been demonstrated by comparing antisera i absorbed with infected reticulocytes, ii absorbed with uninfected reticulocytes, and iii unabsorbed. ferritin labeling was much increased with antiserum preabsorbed with uninfected reticul ...	1982	7036051
plasmodium berghei exoerythrocytic forms develop only in the liver.		1981	7036442
intraerythrocytic plasmodial calcium metabolism.		1981	7036992
plasmodium berghei: architectural analysis by freeze-fracturing of the intraoocyst sporozoite's pellicular system.		1982	7037440
antibodies to the protective antigen of plasmodium berghei sporozoites prevent entry into cultured cells.		1982	7037957
mesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats.	the disposal of immune complexes by the glomerulus and the participation of infiltrating monocytes were studied in acute malaria-associated glomerulonephritis. young sprague-dawley rats were infected with plasmodium berghei. parasitemia reached a maximum after 8 to 12 days, ending by day 20. in all infected rats, renal immunofluorescence microscopy showed in all glomeruli granular deposition of rat igg, igm, and c3 in a mesangial distribution. the staining was strongest from days 8 to 12, then d ...	1982	7038293
isolation and characterisation of ribosomal rna from the human malaria parasite plasmodium falciparum.	ribosomal rna isolated from the malaria parasite plasmodium falciparum consists of two species with molecular weight of 1.49 +/- 0.09 x 10(6) and 0.78 +/- 0.02 x 10(6) present in equimolar quantities. their molecular weights are comparable with those of other protozoa but quite distinct from those of the human host. the overall base composition of the rrna (40% g+c) is close to that of the rodent parasite plasmodium berghei, unlike the latter, however, p. falciparum has no nick in the rna from i ...	1981	7038480
identification of a schizont- and species-specific surface glycoprotein on erythrocytes infected with rodent malarias.	erythrocytes infected with mature trophozoites of plasmodium chabaudi and reticulocytes infected with p. berghei were labelled metabolically in vitro with [35s]methionine. the labelled cells were incubated with normal and immune serum and washed to remove unbound antibody. solubilisation of the antibody-coated cells in detergent was followed by co-precipitation of antibody/antigen complexes and analysis of the immunoprecipitates by sds-page and fluorography. one major parasite polypeptide of 250 ...	1982	7038481
cellular and humoral immune responses in rats experimentally infected with plasmodium berghei.		1981	7040220
chronic, patent plasmodium berghei malaria in splenectomized mice.	it was shown that splenectomized mice could develop a certain resistance to plasmodium berghei but usually no real immunity, since the infection became chronic, often with high parasitemias. a patent infection lasting at least 2 weeks was necessary for the development of this degree of protection. prolonged suppression to subpatent levels (sulfonamide treatment), rather than radical cure (chloroquine), after 2 weeks of patency yielded a higher proportion of mice resistant to superinfection. an i ...	1982	7040249
antimalarial activity of cyclosporin a.	cyclosporin a has been shown to possess antimalarial activity in mice infected with plasmodium berghei nk 65 or plasmodium chabaudi. significant antimalarial effects were obtained with five daily oral doses of 25 mg/kg. cyclosporin a treatment started concurrently with the inoculation of parasites was less effective than treatment started when parasitaemia was already established. evidence so far suggests that the antimalarial action results from a direct toxic effect on the parasite. combined t ...	1981	7041571
lymphocyte traffic and lymphocyte destruction in murine malaria.	normal lymphocytes labelled with 51cr were injected into mice at various stages of lethal and non-lethal malaria infections. marked alterations were seen in the uptake into spleen and liver, which correlated with the outcome of the infection. non-lethal infections and lethal infections in mice protected by vaccination caused increased uptakes, especially in the liver. in lethal infections, particularly plasmodium berghei, uptakes were below normal values at certain times: this was apparently due ...	1982	7042547
inhibition of antibody-binding as a radioimmunoassay for plasmodium berghei infection in rats.	sonicated red blood cells of rats infected with plasmodium berghei (pb) were used to coat plastic tubes, which were subsequently tested for capacity to bind anti-p, berghei antibodies. binding was detected using radioiodinated staphylococcus protein a. two antigenic preparations were used to make the solid-phase adsorbent (and also as inhibitors in the inhibition tests): sonicated red blood cells (sirc), and a supernate of frozen-thawed, infected red blood cells (fte). treatment of the antigen-c ...	1982	7042946
infectivity of in vitro-formed plasmodium berghei ookinetes to mosquitoes.		1982	7042949
superoxide dismutase (sod) in mouse red blood cells infected with plasmodium berghei.		1982	7042950
correlation between susceptibility to malaria and babesia parasites and to endotoxicity.	adult (185g) rats are about twice as sensitive to the harmful effects of injected endotoxin as are younger (65g) rats. this relationship correlates with an earlier report on the densities of plasmodium berghei at which deaths occur in rats of these two age groups. similarly lizards, which withstand very high parasitaemias of malaria parasites, are refractory to very large doses of endotoxin. this correlation appears to hold for malaria and babesiosis in all host species for which information is ...	1982	7043806
comparative studies on the immunogenicity of infective and attenuated sporozoites of plasmodium berghei.		1982	7043807
aspects of immunosuppression during plasmodium berghei infection in rats.	depression in immunological responsiveness was manifested in phase with parasitaemia in rats infected with plasmodium berghei. the spleen was the most affected organ. the response of spleen cells to phytohaemagglutinin (pha) and the number of plaque forming cells among spleen cells of rats injected with sheep red blood cells (srbc), were reduced especially at peak parasitaemia. at the onset of the disease the spleen was activated and the responses were amplified. antibody titres in the serum rev ...	1981	7043823
the antimalarial activity of n-benzyl-oxydihydrotriazines. iii. the activity of 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5,-trichloropropyloxy)-1,3,5-triazine hydrobromide (brl 51084) and hydrochloride (brl 6231).		1982	7044322
the antimalarial activity of n-benzyl-oxydihydrotriazines. iv. the development of resistance to brl 6231 (4,6-diamino-1,2-dihyydro-2-,2-dimethyl-1-(2,4,5-trichloropropyloxy)-1,3,5 triazine hydrochloride) by plasmodium berghei.		1982	7044325
[immunostimulating properties of an extract isolated from aloe vahombe. 2. protection in mice by fraction f1 against infections by listeria monocytogenes, yersinia pestis, candida albicans and plasmodium berghei].	a partially purified extract of leaves of aloe vahombe, a plant endemic in the south of madagascar, administered intravenously to mice, protects them against infection of bacteria (listeria monocytogenes, yersinia pestis), parasites (plasmodium berghei) and fungus (candida albicans). the protective fraction must be administered two days before inoculation of the pathogenic agent. these results significantly confirm those we obtained in earlier study on mice infection by klebsiella pneumoniae. cu ...	1981	7044327
plasmodium berghei: isolation and maintenance of an irradiation attenuated strain in the nude mouse.		1982	7044811
corticosterone regulation of the effector function of malarial immunity during pregnancy.	in the experimental plasmodium berghei mouse model, as in human malaria, reduced maternal responsiveness and even loss of immunity were observed during pregnancy. loss of immunity in the second half of pregnancy occurred during a period of elevated plasma corticoid levels. further analysis showed that plasma corticoid levels were significantly higher in immunodepressed mice than in mice that remained immune throughout pregnancy. plasma corticosterone levels differed increasingly from those in mi ...	1982	7044972
effects of malaria (plasmodium berghei) on the maternal-fetal relationship in mice.	plasmodium berghei infection was more severe in pregnant than in nonpregnant mice. infection initiated on gestation day 7 resulted in rapidly increasing parasitemia and deaths of all pregnant mice within 12 days, while some nonpregnant mice survived until day 21 postinfection. when mice were infected on gestation day 12 or 14, a proportion of mice died before parturition; but some animals survived to deliver living pups. reduced birthweights and increased spleen weight to body weight ratios were ...	1982	7045348
[malaria in the municipality of humaitá, state of amazonas, iv - seroepidemiological aspects of plasmodium berghei antigen].		1981	7046013
[malaria in the municipality of humaitá, state of amazonas. v - serological aspects of plasmodium falciparum and plasmodium berghei antigens].		1981	7046014
[inflammation and resistance of mice against "plasmodium berghei" (author's transl)].	an inflammatory reaction induced in mice by a subcutaneous injection of magnesium silicate embedded in a calcium phosphate gel is followed by an increased resistance against plasmodium berghei. the occurrence of this increased resistance against plasmodium berghei. the occurrence of this increased resistance is related to the time elapsed between the induction of the inflammatory process and the infection. the delayed mortality is correlated with a slowed development of parasitemia. it is hypoth ...	1982	7046621
cross-reactivity and cross-protection in murine malaria.		1982	7046657