Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| design of 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde as a reagent for ultrasensitive determination of primary amines by capillary electrophoresis using laser fluorescence detection. | amino acids and peptides, from both standard solutions and biological samples, were successfully reacted with 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde, at low concentration, to form highly fluorescent isoindole derivatives. the formed mixtures are effectively separated by high-performance capillary electrophoresis and their constituents detected by their laser-induced fluorescence signals. the minimum detectable quantities in the low attomole (10(-18) mol) range are encountered. | 2007 | 2064006 |
| biological warfare and infection control. | though many agents have been proposed as potential biological weapons, the feasibility of biological warfare is largely a matter of conjecture. the unpredictable and indiscriminate devastation caused by natural epidemics during wartime should warn us of the dangers of employing microbes as weapons. | 1991 | 2071880 |
| contralaterally projecting lamina viii interneurones in middle lumbar segments in the cat. | peripheral input to lamina viii interneurones was investigated by using extracellular and/or intracellular records from them. the interneurones were located in the l4-l5 spinal segments and projected to contralateral motor nuclei in the l7 segment. they constituted a non-homogeneous population but their input from muscle afferents (mainly group ii afferents of quadriceps, flexor digitorum longus and pretibial flexors and group i afferents of triceps surae and hamstring nerves) and from cutaneous ... | 1990 | 2073610 |
| deductive reasoning in pigeons. | 2007 | 2074897 | |
| [fractional analysis of urinary alpha-amylase as a probe-free method of diagnosis of biliary dyskinesia in children]. | to diagnose biliary dyskinesia (bd) in children, a method of urine alpha-amylase measurement is offered. it is based on the presence of a direct and close correlation between amylase activity and the amount of endogenous cholecystokinin-pancreozymin in the same portion of the urine. it is concluded that fractional measurement of urine alpha-amylase can be used for diagnosing bd in childhood as a tentative test. it is advisable that it may be used for examining younger children and in cases where ... | 2007 | 2075049 |
| [tuberculous meningitis in children and adolescents at present]. | 2007 | 2075066 | |
| [the design of a diagnostic test system based on magnetic sorbents and liposomes]. | the results obtained in the study of the possibility of using magnetic sorbents for the construction of a diagnostic assay system based on the antigen-antibody interaction are presented. as a model, yersinia pestis capsular antigen and immunoglobulins to it have been used. a solid-phase immunofluorescent liposomal assay method has been developed; this method can be used for the detection of biopolymers in the sample under study and for the determination of their activity. | 1990 | 2075755 |
| [the utilization of heme iron by yersinia pestis in human blood and blood sera]. | y. pestis, the causative agents of plague, have been found to be incapable of using heme iron bound to haptoglobin and hemopexin complexes in human blood and blood serum, and protein components of the serum are not the factors inhibiting this process. at the same time iron of free hemoglobin can be successfully utilized by y. pestis in the systems used in this study. on the contrary, hemin not only produces any stimulating effect on the growth of y. pestis in blood serum, but leads to the death ... | 1990 | 2075759 |
| [seroepidemiologic survey on plague in an endemic zone: cumulative results: 1987-1990]. | plague is a bacterial disease, induced by yersinia pestis growth in rodents, with human transmission by fleas. in numerous cases, lymph node reaction is important. this survey (329 patients and contacts) is the most extensive ever realised, associating plasmidic virulence and immunity studies. from the results, we can retain that: all the strains were 47 plasmid+. the immunity was precocious, specific, of high titer and persistent. in conclusion, in plaque endemic zone, high bacillus circulation ... | 1990 | 2078084 |
| [comparative study of 5 european tables of food composition (study of european tables of food composition)]. | a comparative study has been made of the following nutritional data base: (a) c.s.i.c. (spain); (b) deutsche forschungsanstalt für lebensmittel chemie, garching; (c) inserm (france); (d) geigy; (e) wander. the following values were researched: calorie, protein, carbohydrate, fiber, calcium, iron, magnesium, vit. b1, vit b2, niacin, folic acid, vit. b12 and vit. c. in order to assess the use of these tables under different conditions, the following were researched: 1) a group of 10 essential repr ... | 2007 | 2078596 |
| [health policy. who will continue to be a champion for the weak]. | 2006 | 2080457 | |
| [the use of biostatistical analysis in the expertise of disputed paternity]. | 2007 | 2080531 | |
| [a case of zoocoumarin poisoning]. | 2007 | 2080547 | |
| homocysteic acid as an endogenous excitatory amino acid. | 1990 | 2080552 | |
| identification and characterization of a gene and protein required for glycosylation in the yeast golgi. | the mnn2 gene of saccharomyces cerevisiae has been cloned by complementation of the mnn2 mutant phenotype scored by a change in cell surface carbohydrate structure resulting from a lack of alpha 1----2-mannose branching in the outer chain. the gene was subcloned as a 3 kb dna fragment that integrated at the mnn2 locus, and a gene disruption yielded the mnn2 phenotype. a lacz-mnn2 gene fusion protein, produced in escherichia coli, was used to raise a specific antiserum that recognized a 65 kd wil ... | 1990 | 2082155 |
| dietary carbohydrate source and copper bioavailability. | the accentuation of deficiency signs in male rats indicates that a high intake (60% of calories) of fructose and sucrose decreases the bioavailability of dietary copper as compared with the bioavailability when starch is the carbohydrate source. while there are few quantitative data, it appears that under these conditions copper bioavailability may be 30% lower in the presence of sucrose or fructose. this phenomenon has not been observed in female rats, and there is little evidence that the resu ... | 1990 | 2082222 |
| testosterone-induced acceleration of recovery from facial paralysis in male hamsters: temporal requirements of hormone exposure. | in this study, the temporal requirements of testosterone propionate (tp) exposure necessary for acceleration of recovery from facial paralysis to occur following facial nerve crush were examined. for each of two series of experiments, adult castrated male hamsters were subjected to crush axotomies of the facial nerve at its exit from the stylomastoid foramen. in the first experimental paradigm, one-half of the animals with facial nerve crush axotomies received subcutaneous tp capsules beginning ... | 1960 | 2082378 |
| [psycho-physiological evaluation of sleep and body-temperature biorhythm in neuroses treated by "morita therapy"]. | 1960 | 2082382 | |
| morbidity and mortality of myocardial infarction in the augsburg monica study area in 1985, 1986 and 1987. | in the years 1985, 1986 and 1987, the monica augsburg coronary event register recorded 1488 coronary events (1214 men and 274 women) occurring in 35-64 year old residents of the study region (population: 102,000 men and 105,000 women). the rates presented include all coronary events with a definite acute myocardial infarct (ami), possible ami, resuscitated cardiac arrest, and insufficient data. the age-standardized attack rates in men are 390 (1985) to 372 (1987) and in women 51 (1985) to 72 (19 ... | 1961 | 2082446 |
| long-term memory for a single infancy experience. | children's memory of a single infant experience was evaluated. children in the experimental groups (n = 16 for 2.5-year-olds; n = 8 for 1.5-year-olds) had participated at 6.5 months in a study of auditory localization where they reached in the light and dark for a sounding object. they were reintroduced to the laboratory and the dark procedure they had experienced on that one occasion either 1 or 2 years previously. the first 5 trials were uninstructed; for the remaining 5 trials, children were ... | 1956 | 2083499 |
| the structure of temperamental fear and pleasure in infants: a psychometric perspective. | despite the prominence of temperament constructs in the study of infant development, little evidence exists about the internal structure of temperament. we assessed temperament both via questionnaire and in repeated laboratory visits for 168 9-month-old twins and singletons. mothers' and fathers' agreement on temperament questionnaire scales was low, except for scales tapping negative emotionality and activity level. the factor structure of mothers' and fathers' questionnaire scales also differe ... | 1956 | 2083507 |
| interaction of lectins with yersinia pestis strains. | the ability of lectins to interact with yersinia pestis strains isolated from rodent fleas and human biological fluids, obtained from different geographic areas, was examined. lectins of canavalia ensiformis, ulex europaeus, phaseolus vulgaris, and triticum vulgaris, as well as a new autochthonous lectin of swartzia pickellii of undefined specificity, were used. most of the y. pestis strains did not agglutinate with u. europaeus or c. ensiformis lectin. however, p. vulgaris lectin agglutinated s ... | 1990 | 2091525 |
| [left ventricular performance following mitral valve replacement in patients with tight mitral stenosis combined with mild aortic regurgitation]. | the severity of aortic regurgitation is difficult to estimate prior to mitral valve replacement (mvr) in cases with tight mitral stenosis (ms), because low output state due to mitral obstruction masks signs of aortic regurgitation. this study clarified left ventricular performance, possibly affected by increased diastolic loading after mvr. the study subjects consisted of 12 patients with pure mitral stenosis (ms group) and 11 with combined mitral stenosis and aortic regurgitation (msar group). ... | 1967 | 2093749 |
| immunochemical localization of the fraction-1 antigen, a virulence determinant of yersinia pestis. | the distribution of yersinia pestis fraction-1 (f1) antigen was analyzed in cells grown at 28 degrees c and 37 degrees c. fractionation of y. pestis cells followed by analysis in sds-polyacrylamide gel electrophoresis indicated that the mature form of the f1 antigen is localized in the extracellular matrix and in the cytoplasm. localization of the f1 antigen was confirmed by immunoblots and a single peptide with a molecular weight of 17,000 daltons was recognized. electron microscopy of y. pesti ... | 1990 | 2094179 |
| [aminoacyl-trna synthetases (codases) and their noncanonical functions]. | the aim of this review is to summarize the data obtained in the author's laboratory during the last decade. the main objects of these investigations were mammalian aminoacyl-trna synthetases, mainly bovine tryptophanyl-trna synthetase (ec 6.1.1.2). the data are discussed and compared with those described in literature. in the course of these studies it turned out that some properties of mammalian aminoacyl-trna synthetases for instance, nuclear location of some of the synthetases, presence of ex ... | 1990 | 2094804 |
| [demand of community health services in the periphery of a metropolitan area]. | the content of 4,319 consultations in primary health care representing 7% of all consultations from march, 1985 to march, 1986 at the murialdo health center, was analyzed. the health center is located in the outskirts of porto alegre, rs (brazil). woman represented 67% of the total demand. most consultations were for children under 10 years of age (37%) and woman of childbearing age (21%). the first twenty reasons for the visit corresponded to 63% of the total, and the most common reason for vis ... | 2003 | 2094954 |
| comparative studies of yersinia pestis outer membrane isolation techniques and their potential use in plaque epidemiology. | in the present study three techniques for obtaining outer membrane enriched fractions from yersinia pestis were evaluated. the techniques analysed were: differential solubilization of the cytoplasmic membrane with sarkosyl or triton x-100, and centrifugation in sucrose density gradients. the sodium dodecyl-sulfate polyacrylamide gel electrophoresis (sds-page) of outer membrane isolated by the different methods resulted in similar protein patterns. the measurement of nadh-dehydrogenase and succin ... | 1990 | 2095628 |
| [the isolation and characteristics of variant plague microbes not producing the capsular antigen]. | fifteen stable variants of yersinia pestis strains exhibiting different degrees of virulence for white mice and guinea pigs were obtained. multiple passages of the organisms at 37 degrees c in a fluid nutrient medium containing antiplague agglutinating serum were found to be the most efficient method for obtaining noncapsular forms of the plague agent. acquisition of the fra(-) phenotype both by wild and laboratory strains was not associated with a loss of the high-molecular plasmid by cells but ... | 1990 | 2097497 |
| [the tissue heterogeneity of mononuclear phagocyte system cells interacting with yersinia pestis]. | the work deals with the determination of the heterogeneity of cells of the mononuclear phagocyte system, localized in different tissues, in their interaction with y. pestis. the macrophage populations under study have been found to be heterogeneous in their phagocytic activity with respect to y. pestis. the digestive activity of alveolar macrophages is considerably lower than that of macrophages localized in other tissues. macrophages obtained from different tissue are heterogeneous also in the ... | 1990 | 2097850 |
| [y. pestis phage of a new serovar]. | phage ii, isolated from y. pestis strain 2247 obtained from a desert focus in central asia, has been studied. the phage is classified with moderate phages and essentially differs from moderate phages of serovar 2. the sources of isolation, high specificity and the absence of common serological features with presently known y. pestis phages of serovars 1 and 2 permit the classification of this phage with new serovar 3 of y. pestis phages. | 1990 | 2097853 |
| quality of life in adults with insulin-dependent diabetes mellitus. | conventional measures of psychiatric or medical morbidity do not adequately reflect the consequences of chronic illness. quality of life refers to a more comprehensive assessment of the impact of illness. uncomplicated insulin-dependent diabetes is usually associated with mild reported reduction in quality of life. increased depressive and anxiety disorders have been reported in individuals with insulin-dependent diabetes mellitus, particularly in association with more severe medical complicatio ... | 2007 | 2098775 |
| [the lytic activity of yersinia pestis phage p 3d serovar]. | the lytic activity of plague phage ii, serovar 3, with respect to 1,800 bacterial strains has been studied: 760 yersinia pestis strains, 262 y. pseudotuberculosis strains, 252 y. enterocolitica strains, 166 escherichia coli strains, 90 shigella strains and 270 strains of other species. the phage has been found to lyse 81.8% of y. pestis strains, 1 y. pseudotuberculosis strain and 1 y. enterocolitica strain. the representatives of other 19 bacterial species have proved to be resistant to the phag ... | 1990 | 2099066 |
| [a polarographic method in assessing the cultural properties of the ev vaccinal strain]. | the kinetic and regulatory characteristics of the oxidation metabolism of glucose, whose differences in collection cultures correspond to their capacity for growth in fluid culture medium under the conditions of aeration and the periodic addition of glucose, have been proposed on the basis of the polarographic method used for the registration of microbial breath in vaccine strain ev. pronounced metabolic disturbances resulting from the prolonged storage of the stock culture and working standards ... | 1990 | 2099067 |
| [the use of the macrophage disappearance reaction for detecting delayed hypersensitivity to yersinia pestis antigens]. | the possibility of using the reaction of macrophage disappearance (rmd) for the detection of delayed hypersensitivity (dh) to y. pestis has been studied. as the result of these studies, rmd has been found suitable, in principle, for use in the quantitative evaluation of dh to y. pestis. high sensitivity and specificity of this reaction have been established. the presence of dh in the process of the formation of immunity after immunization with y. pestis antigen fia has been shown. rmd can be obs ... | 1990 | 2099076 |
| [the role of macrophages in the immunogenesis of plague]. | 1990 | 2099079 | |
| [derivative spectroscopy and its use in sanitary hygiene control]. | an analytical method is developed for defining the residual quantities of rodenticide "brodifacoum" (talon) used in the control of harmful field rodents and especially for species microtus. the method is based on extracting the pesticide with chloroform and making use of spectrophotometry in the ultraviolet field in intervals 340-240 nm. the second derivative of the absorption is utilized as well as the band with maximum 288 nm and minimum 228 nm. the peak height in this interval is in proportio ... | 2007 | 2099444 |
| serologic survey of selected zoonotic disease agents in black-tailed jack rabbits from western texas. | a serologic survey for the agents of rocky mountain spotted fever (rmsf) (rickettsia rickettsii), borrelia spp. including the causative agent for lyme disease (borrelia burgdorferi), and plague (yersinia pestis) was conducted on blood samples collected from 30 and 46 black-tailed jack rabbits (lepus californicus) from an urban environment in lubbock, texas (usa) during winter 1987 and the following spring 1988, respectively. antibody titers to the agents of rmsf and borreliosis were detected in ... | 1990 | 2106044 |
| cloning, sequence analysis, and expression of genes encoding xylan-degrading enzymes from the thermophile "caldocellum saccharolyticum". | a lambda recombinant bacteriophage coding for xylanase and beta-xylosidase activity has been isolated from a genomic library of the extremely thermophilic anaerobe "caldocellum saccharolyticum." partial sau3ai fragments of the lambda recombinant dna were ligated into pbr322. a recombinant plasmid with an insertion of ca. 7 kilobases of thermophilic dna expressing both enzymatic activities was isolated. the location of the genes has been established by analyzing deletion derivatives, and the dna ... | 1990 | 2111111 |
| interferon-gamma: mechanism of action and therapeutic potential. | 2007 | 2121146 | |
| imported bubonic plague--district of columbia. | 1990 | 2123285 | |
| secretion of yop proteins by yersiniae. | upon incubation at 37 degrees c in the absence of ca2+ ions, pathogenic strains of the genus yersinia cease growing and produce large amounts of a series of plasmid-encoded proteins involved in pathogenicity. these proteins, called yops (for yersinia outer membrane proteins), are detected in both the outer membrane fraction and the culture supernatant. we present here the nucleotide sequence of genes yop20 and yop25 from yersinia enterocolitica o:9. protein yop25 is very similar to yope, the cor ... | 1990 | 2129533 |
| [obesity in a walk-in consultation office]. | the weight, height, body mass index (bmi) and deviation from the ideal weight according to tables were measured in the patients over 24 years who spontaneously attended a demand clinic. these data permitted to calculate the prevalence of obesity in the demand clinic, and its relation with age, sex, frequentation rate and type of consultation were evaluated. 301 subjects were included, 113 males and 188 females, with a mean age of 53.43 +/- 10.68 years. according to their bmi, 52.62% were obese. ... | 1986 | 2129654 |
| [improvement of health care by studies of guaranteed quality]. | 1977 | 2129730 | |
| association-dissociation processes and supermolecular organisation of the capsule antigen (protein f1) of yersinia pestis. | the association-dissociation processes involving the capsule antigen of yersinia pestis were investigated. in aqueous salt solutions the material of the capsule (protein f1) exists in the form of associated species containing identical monomeric protein subunits. brief heating (100 degrees c, 3 min) of f1 dissolved in buffered salt solutions at phs between 4.4 and 7.5 leads to dissociation of the antigen into oligomers which reassociate at room temperature into aggregates of high molecular mass. ... | 1990 | 2133058 |
| [effect of ascorbic acid for periodontal ligament fibroblast of human deciduous and permanent teeth]. | ascorbic acid (asa) plays an important role in the formation of collagen in the periodontal ligaments. however, the biochemical role of asa on the cell metabolism of periodontal ligaments remains undeveloped. this study attempts to explore the effect of asa and l-ascorbic acid-2-phosphate (asa-p) on the cell proliferation and differentiation, and the activity of cell attachment and spreading of conditioned medium (cm) prepared from human fibroblasts derived from the periodontal ligaments of deci ... | 1990 | 2134885 |
| [effect of ascorbic acid for periodontal ligament fibroblast of human deciduous and permanent teeth]. | ascorbic acid (asa) plays an important role in the formation of collagen in the periodontal ligaments. however, the biochemical role of asa on the cell metabolism of periodontal ligaments remains undeveloped. this study attempts to explore the effect of asa and l-ascorbic acid-2-phosphate (asa-p) on the cell proliferation and differentiation, and the activity of cell attachment and spreading of conditioned medium (cm) prepared from human fibroblasts derived from the periodontal ligaments of deci ... | 1990 | 2134885 |
| [the regulation of re-selection form in the aesthetic factor of upper anterior artificial teeth]. | sixty one cases of selection error due to the esthetic factors of artificial tooth forms were investigated out of the 72 cases of selection error which were committed at the department of prodosthontics in nihon university school of dentistry at matsudo for 17 years from 1971 to 1988. the following were the results of investigation, 1. the cases of s-type were changed to those of st-type, which emphasized the tapering type factors. 2. the those of st-type were changed to those of so-type and s-t ... | 2007 | 2134951 |
| [clinical evaluation of protocol for the craniomandibular disorders. 2. craniomandibular disorders according to new classification]. | the purpose of this study is to clarify the actual state in the patients with extensive pathological states of craniomandibular disorders (cmds). 100 patients, with their ages ranging from 11 to 77 years old, were selected for the study and they were divided into 5 groups according to classification of japanese society for temporomandibular joint. the following results were obtained: 1. by classification type, the ratio was 88, 16, 8 and 2% for type iii, type i, type iv and type ii. type v was n ... | 2007 | 2134952 |
| testing for allergic disease. | 2007 | 2134986 | |
| limitations of double-blind trials. | 1956 | 2136594 | |
| the design and effectiveness of a graduate survey course in quality assurance and utilization review. | this paper reports on the design, presentation, and evaluation of a graduate university course in quality assurance and utilization review. the authors cite the need for expanded course offerings in this field and present descriptions of the course design and student participants, including program location, objectives, learning themes and content, instructor team, students, and course process. student feedback is reported including comments on course strengths and needs, teaching methods, and l ... | 1957 | 2136678 |
| oxytocin, vasoactive-intestinal peptide, and serotonin regulate the mating-induced surges of prolactin secretion in the rat. | in female rats the mating stimulus induces a bimodal pattern of prl secretion. a surge of prl occurs at approximately 0300 h, called the nocturnal surge (n). another surge occurs at 1700 h on the same day, called the diurnal surge (d). by lowering dopaminergic tone pharmacologically, we have recently demonstrated the existence of an endogenous rhythm stimulatory to prl secretion in female rats. the periods of this stimulatory influence coincide with the periods of the n and d surges of prl that ... | 1990 | 2136724 |
| serum ferritin as a marker of therapeutic response in stage iii and iv breast cancer. | ferritin concentrations have been measured in serum from 266 patients receiving primary endocrine therapy for advanced breast cancer. concentrations were significantly higher at presentation of advanced disease than in 55 tumour-free control patients. a positive correlation existed between increasing serum ferritin and tumour burden at presentation. a strong correlation was also found between therapeutic response and changes in serum ferritin (above 200 micrograms/l) in patients with distant met ... | 1964 | 2137790 |
| analysis of cis-acting requirements of the rh3 and rh4 genes reveals a bipartite organization to rhodopsin promoters in drosophila melanogaster. | the rhodopsin genes of drosophila melanogaster are expressed in nonoverlapping subsets of photoreceptor cells within the insect visual system. two of these genes, rh3 and rh4, are known to display complementary expression patterns in the uv-sensitive r7 photoreceptor cell population of the compound eye. in addition, we find that rh3 is expressed in a small group of paired r7 and r8 photoreceptor cells at the dorsal eye margin that are apparently specialized for the detection of polarized light. ... | 2007 | 2140105 |
| [the expression of fc gamma receptors on the surface of macrophages activated by a vaccinal strain of yersinia pestis]. | the expression of fc gamma r on the surface of macrophages in the process of antiplague immunity formation is analyzed. the stud is performed on the alveolar and peritoneal macrophages obtained from intact and immunized guinea pigs in different periods after vaccination (the 1st, 7th, 14th and 21st day). it is established that during the formation of the antiplague immunity there occurs activation of macrophages which is accompanied by an increase of the fc gamma r expression on the outer surfac ... | 1990 | 2142978 |
| [the role of t-suppressors in the formation of plague immunity in mice]. | antiplague immunization of mice causes an increase in the number of t-suppressors in their thymus and spleen; this increase is especially pronounced after injection of a low-immunogenic dose of the vaccine strain. t-suppressors specific to yersinia pestis antigens were detected in the thymus on day 3 after a single injection and on day 14 after two injections of the vaccine strain. | 1990 | 2143614 |
| [the epizootiological preconditions and clinico-epidemiological characteristics of a case of plague in 1988 in the settlement of kazbek, guryev province]. | 1990 | 2146843 | |
| [the sensitivity of yersinia to bacteriophage mu]. | various representatives of the genus yersinia were found to differ in their sensitivity to the lytic action of bacteriophage mu cts62, which could serve as an auxiliary test for the differentiation of y. pestis and y. pseudotuberculosis. among the strains under study, the causative agents of plague (34 strains) were sensitive to phage mu cts62, while the causative agents of enteric yersiniosis (42 strains) and pseudotuberculosis (73 strains), except 3 strains with the properties of y. pestis, we ... | 1990 | 2146845 |
| delay of puberty and impairment of growth in female rats given a non competitive antagonist of nmda receptors. | reportedly, excitatory amino acids are involved in the control of gonadotropin secretion of rats and non-human primates. the aim of this study was to investigate the effect of chronic blockade of nmda (n-methyl-d-aspartic acid) receptors by the non competitive receptor antagonist mk-801 on gonadotropin secretion and the onset of puberty in female rats. moreover, since in humans alterations of the timing of puberty frequently coexist with disturbances of body growth, suggesting a common etiology ... | 1990 | 2147050 |
| membrane potential and na(+)-k+ pump activity modulate resting and bradykinin-stimulated changes in cytosolic free calcium in cultured endothelial cells from bovine atria. | the effects of membrane potential on resting and bradykinin-stimulated changes in [ca2+]i were measured in fura-2 loaded cultured endothelial cells from bovine atria by spectrofluorimetry. the basal and bradykinin-stimulated release of endothelium-derived relaxing factor, monitored by bioassay methods, were dependent on extracellular ca2+. similarly, the plateau phase of the biphasic [ca2+]i response to bradykinin stimulation exhibited a dependence on extracellular ca2+, whereas the initial tran ... | 1990 | 2154452 |
| simultaneous primary infection with hiv and cmv leading to severe pancytopenia, hepatitis, nephritis, perimyocarditis, myositis, and alopecia totalis. | simultaneous primary infection with hiv and cmv in an 18-year-old woman led to an acute cytotoxic reaction, manifesting as pancytopenia, hepatitis, nephritis, perimyocarditis, and myositis. within 14 days parameters indicating acute cell damage reverted to normal. two weeks later transient alopecia totalis developed. initially, hiv-antigen but no hiv antibodies were present. within 3 weeks hiv-igg antibodies appeared while hiv antigen disappeared. anti-cmv-igm was clearly and anti-cmv-igg questi ... | 1990 | 2156107 |
| [protein phosphorylation in the causative agent of plague]. | the phenomenon of the reversible phosphorylation of proteins has been discovered in y. pestis cells. eight proteins with a molecular weight of 30-80 kilodaltons have been found capable of phosphorylation. the intensity of phosphorylation has been found to be influenced by the temperature of cultivation and the composition of the incubation medium. this newly found phenomenon of the chemical modification of proteins is supposed to play a certain role in the organization of rapid responses of the ... | 1990 | 2158704 |
| the lcre gene is part of an operon in the lcr region of yersinia enterocolitica o:3. | the low-calcium response (lcr) region of the virulence plasmid of yersinia pestis, yersinia pseudotuberculosis, and yersinia enterocolitica has been associated with calcium-dependent growth of bacteria. mutations in the previously identified lcre locus within the lcr region lack the repressor control of production of the lcr specific proteins, yersinia outer membrane proteins (yops) and v and w antigens. we sequenced a 3.3-kilobase-pair bamhi-clai fragment of the lcre locus of pyvo3, the virulen ... | 1990 | 2160939 |
| yersinia pestis ph 6 antigen: genetic, biochemical, and virulence characterization of a protein involved in the pathogenesis of bubonic plague. | we studied a protein antigen, designated ph 6 ag, that has the same regulation of expression as the previously described yersinia pestis ph 6 ag. monospecific antiserum to this antigen recognized several proteins, ranging from 15 to over 75 kilodaltons (kda), which were strongly expressed when y. pestis was cultivated at 37 degrees c and ph 6 but were expressed weakly, if at all, at 37 degrees c and ph 8 and at 26 degrees c. the antigen appeared to be composed of aggregates of a 15-kda subunit. ... | 1990 | 2164509 |
| [the use of mini-mu-replicons for cloning of various structural genes of yersinia pestis]. | the possibility to clone the structural leu gene of yersinia pestis in vivo using the mini-mu bacteriophages with the inserted plasmid replicones has been demonstrated. the e. coli k12 transductants having obtained the leu(+)-marker within the cloned 4.8-21 kb fragments stably inherited the leu-gene within the autonomous mini-mu replicones. the possibility to clone other yersinia pestis genes by the same technique has been demonstrated. | 1990 | 2166239 |
| comparison of double-burst and train-of-four stimulation to assess neuromuscular blockade in children. | double-burst stimulation (dbs), a new technique to evaluate neuromuscular function, consists of two 50-hz trains of 60-ms duration and 750 ms apart. dbs was compared with train-of-four (tof) stimulation in 21 children aged 3-10 yr, during halothane anesthesia. on one arm the ulnar nerve was stimulated supramaximally with tof stimulation every 12 s and the force of the evoked contraction of the adductor pollicis measured with an fto3 force transducer and recorded on paper. atracurium (0.4-0.5 mg. ... | 2007 | 2168135 |
| past and future of neuropsychopharmacology. | the advent of what is called the chemotherapy of mental diseases goes back to the early fifties, when a series of clinical observations led medical research to reconsider this field, that at the time was not particularly developed. the use of chlorpromazine and of reserpine in the therapy of some psychotic syndromes dates back to that time. a few years later meprobamate was introduced and proved active against anxiety. the success obtained with these drugs was followed by a flourishing of resear ... | 1990 | 2168139 |
| kinetics of the reaction of prostaglandin h synthase compound ii with ascorbic acid. | the reduction of prostaglandin h synthase compound ii by ascorbic acid in the presence of diethyldithiocarbamate was studied in 0.1 m phosphate buffer (ph 8.0) at 4.0 +/- 0.5 degrees c, by rapid scan spectrometry and transient state kinetics. a saturation effect and nonzero intercept were observed in the plot of pseudo-first-order rate constant versus ascorbic acid concentration. the saturation behavior suggests formation of a complex between prostaglandin h synthase compound ii and ascorbic aci ... | 1990 | 2168160 |
| detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas. | somatostatin (ss) receptor status was investigated in the tumor tissues from 62 patients with carcinoid tumors and 15 patients with islet cell carcinomas using receptor autoradiography techniques with two different iodinated somatostatin analogues as radioligands, a [leu8, dtrp22, tyr25]somatostatin-28 and a somatostatin octapeptide, tyr3-octreotide. the carcinoid tumors were either primaries (n = 32) or metastases (n = 43), sampled as surgical specimens or as small needle liver biopsies. fifty- ... | 2007 | 2168286 |
| the antiphospholipid antibody dilemma. | 2007 | 2168305 | |
| identification of genes affecting production of the adhesion organelle of caulobacter crescentus cb2. | transposon (tn5) mutagenesis was used to identify regions in the genome involved with production, regulation, or attachment to the cell surface of the adhesive holdfast of the freshwater bacterium caulobacter crescentus cb2. a total of 12,000 independently selected transposon insertion mutants were screened for defects in adhesion to cellulose acetate; 77 mutants were detected and examined by southern blot hybridization mapping methods and pulsed-field gel electrophoresis. ten unique sites of tn ... | 1990 | 2168382 |
| [control of interstitial pneumonia with the application of immune transfer]. | allogeneic bone marrow transplantation (bmt) has been used successfully to treat patients with hematological malignancies. however, interstitial pneumonia has remained a major complication following bmt. we investigated the possibility of immune transfer in recipients treated with bmt from immunized donors. bone marrow donors were vaccinated with tetanus toxoid (tt) before marrow harvest. after bmt, serum igg anti-tt antibody titer and in vitro igg anti-tt antibody production in recipients were ... | 1990 | 2168493 |
| determination of bhv1 specific immune reactivity in naturally infected and vaccinated animals by lymphocyte proliferation assays. | the in vitro bhv1-specific lymphocyte stimulation assay was used to investigate immune reactivity of cattle after natural infection or vaccination with bhv1. proliferative responses to live virus were shown in tests with peripheral blood lymphocytes of seropositive field virus-infected animals and of vaccinated animals. nineteen out of 36 seropositive field virus-infected animals did not show in vitro responses. nine out of 12 animals showed, at least transient, responsiveness after vaccination. ... | 1990 | 2168602 |
| protective effect of inactivated pasteurella haemolytica bacterin challenged in bovine herpesvirus-1 experimentally infected calves. | formalin-inactivated and sonicated pasteurella haemolytica bacterins were prepared from 1 h cultures of bacterial pellets in rpmi-1640 medium containing 7% fetal calf serum. the bacterial pellets were obtained from logarithmic phase growth of the organism by centrifugation. the protective effect of the vaccine was evaluated in 43 specific-pathogen-free hereford crossbred calves and yearlings in three experiments. cattle were either single vaccinated or boosted via three routes; intratracheally ( ... | 1990 | 2168606 |
| [brain stem auditory evoked potentials in the early period after a brain concussion]. | acoustic truncal evoked potentials (atep) were studied in 24 patients in the first 48 hours after concussion of the brain. the absolute peak latency of components 1, 3, and 5, the interpeak intervals 1-3, 3-5, and 1-5, and the interaural difference were determined. the results were compared with those of examination of a control group of 24 healthy individuals. individual and group appraisal failed to reveal any significant differences from normal values in none of the studied parameters in pati ... | 2007 | 2168645 |
| [the topographic anatomical basis for ventriculosinusal shunting in hydrocephalus in nursing and young infants]. | the peculiarities in the structure and topographic anatomical relations of the superior longitudinal, lateral, and sigmoid sinuses were studied on block preparations of the posterior cranial fossa of 14 children under 3 years of age who died from somatic diseases. it was shown that intrasinus inclusions preventing catheterization of the sinus (bands and septa) were absent at the junction of the first angle of the sigmoid sinus with its descending part. the authors recommend this area for shuntin ... | 2007 | 2168650 |
| mechanisms underlying the stimulation of pth release by gppnhp in permeabilized bovine parathyroid cells. | we examined changes in camp and inositol phosphate metabolism to assess the contribution of the guanine nucleotide regulatory (g) protein(s) regulating adenylate cyclase and phospholipase c in mediating the stimulatory effects of gppnhp on pth release from permeabilized bovine parathyroid cells. to examine the role of gs, the g protein stimulating adenylate cyclase, and camp on pth release, permeabilized cells were incubated with either gppnhp or isoproterenol, and the effects of these agents on ... | 1990 | 2168660 |
| effect of particle size and temperature on the conformation and physiological behavior of apolipoprotein e bound to model lipoprotein particles. | the effect of particle size and structural order/disorder of the lipid domain on the conformation and physiological behavior of lipid-associated apolipoprotein e (apoe) was evaluated. circular dichroic (cd) spectra of apoe bound to large (lme) and small (sme) microemulsion particles, composed of dimyristoylphosphatidylcholine (dmpc) and cholesteryl oleate (co), and to dmpc disks revealed that at 4 degrees c, where all of the lipid constituents were in an ordered state, apoe bound to lme displaye ... | 1990 | 2168737 |
| [a case of malignant aortico-pulmonary paraganglioma]. | a 64-year-old male was admitted to our hospital suffering from dysphagia and dyspnea. the chest x-ray films and chest ct films revealed huge tumor in his upper-anterior mediastinum. the filling defect at lower rim of the left brachiocephalic vein on venography indicated malignant potential of the tumor. there was no abnormal value in blood and urine examinations except ca 19-9 which was 31.8 u/ml. the tumor was resected with bilateral pleura, pericardium and left brachiocephalic vein. macroscopi ... | 2007 | 2168923 |
| characterization of vasoactive intestinal peptide receptors in retina. | vasoactive intestinal peptide (vip) is a neuropeptide having a wide range of effects on a large number of tissues. to gain insight into the role vip plays in retinal function, vip receptors in bovine retinal membranes were analyzed in competition binding assays and by affinity labeling studies and compared to vip receptors in rat liver membranes. in both membrane preparations, high affinity vip binding sites (kd approximately 1 nm) were detected. secretin and glucagon, each having close structur ... | 1990 | 2169429 |
| osteoblasts display receptors for and responses to leukemia-inhibitory factor. | specific binding of leukemia-inhibitory factor (lif) to osteoblasts, but not multinucleated osteoclasts, was demonstrated by receptor autoradiography by using cells isolated from newborn rat long bones. the clonal rat osteogenic sarcoma cells, umr 106-06, which have several phenotypic properties of osteoblasts, expressed 300 lif receptors per cell, with an apparent kd of 60 pm. treatment of calvarial osteoblasts or umr 106-01 cells with lif resulted in a dose-dependent inhibition of plasminogen ... | 1990 | 2170427 |
| biphasic effects of polarizing current on adenosine-sensitive generation of cyclic amp in rat cerebral cortex. | cyclic amp accumulation elicited by adenosine was investigated in cortical slices of rats following the application of a weak anodal direct current (anodal polarization) to the unilateral sensorimotor cortex. anodal polarization with 3.0 microa for 30 min caused an increase in the adenosine-elicited accumulation of cyclic amp in the polarized cortex, in which case the increase in the polarized cortical region was highlighted by repeated applications of the currents. polarization with 0.3 microa ... | 1990 | 2173816 |
| detection of bovine viral diarrhea virus in serum from cattle by dot blot hybridization assay. | a dot blot hybridization assay was developed for use as a rapid screening test to detect bovine viral diarrhea virus (bvdv) in serum from infected cattle. a 1.1. kilobase cdna, prepared from the bvdv genome, was molecularly cloned and used in this study. insert cdna was removed from the puc9 plasmid vector by pst-i restriction endonuclease digestion and purified from plasmid dna by agarose electrophoresis and electroelution. the hybridization probe was prepared by nick translation in the presenc ... | 1990 | 2175527 |
| [comparative evaluation of clinical and economic effectiveness of preventive therapy of affective and schizoaffective psychoses]. | the authors provide the results of a comparative study into the action of different drug approaches to the prevention of relapses of affective and schizoaffective psychoses with the aid of multifactorial consideration of different clinical, economic and socioeconomic indicators characterizing the "benefits and losses" because of the use of carbamazepine and lithium carbonate. the comparative analysis has shown a high normothymic activity of carbamazepine and lithium carbonate in the patients exa ... | 2007 | 2176049 |
| [a cyclic 3',5'-adenosine monophosphate-binding protein in the causative agent of plague]. | camp-binding protein was isolated from the plaque agent and purified to the homogeneous state. purification process included filtration of the initial preparation through the membrane able to transmit particles with mol. weight to 300,000 da, chromatography on cellulose "de-52" and biogel htp. the protein homogeneity was confirmed by electrophoresis in polyacrylamide gel and precipitation with commercial plague agglutinating serum. the protein with mol. weight of 180,000 da consisted of two iden ... | 1990 | 2177132 |
| [the role of is-elements of yersinia pestis (lehmann, neumann) in the emergence of calcium-independent mutations]. | calcium independent mutants of two yersinia pestis strains were studied. insertions of is100 element at three different sites of plasmid pcad within calcium dependence region were detected in y. pestis ev, as well as two extensive deletions covering the whole region. it was shown that is100 carries no hindiii sites. novel is element of y. pestis designated is101 was discovered in strain 358, in addition to is100. it is distinguished by a slightly smaller size, hindiii site presence and high spec ... | 1990 | 2178143 |
| [function of large plasmids of the plague pathogen]. | function of the largest plasmid of yersinia pestis was studied. assay of four strains of highly virulent y. pestis isolated from different natural sources demonstrated that the characters of endotoxin production, sugar and alcohol fermentation, nitrate reduction as well as requirement in nutrients are mediated by no y. pestis plasmids. on the contrary, fi and fii antigens are determined by the largest plasmid in some strains and are chromosome-mediated in others. it may well be that the genes fo ... | 1990 | 2178144 |
| stimulation of renin synthesis in the hydronephrotic kidney during sodium depletion. | 2008 | 2186360 | |
| [the discovery of yersinia pestis]. | 1990 | 2188341 | |
| [gennadiĭ mikhaĭlovich pavlov (on the centenary of his birth)]. | 2008 | 2190542 | |
| clinical manifestations of hiv infection, including persistent generalized lymphadenopathy and aids-related complex. | the ability to recognize disease related to the human immunodeficiency virus (hiv) and subsequent acquired immunodeficiency syndrome (aids) has improved in recent years with refinement of laboratory techniques. because of this progress, several clinical conditions can now be identified as "pre-aids" syndromes. these include the persistent generalized lymphadenopathy syndrome, immune thrombocytopenic purpura, the wasting syndrome, and certain predominantly neurologic presentations. all are charac ... | 1990 | 2193949 |
| applications of exercise radionuclide ventriculography in the clinical management of patients with coronary artery disease. | exercise radionuclide ventriculography is commonly used in patients with coronary artery disease, for both diagnostic purposes and patient management decisions. both applications are reviewed in this article. there has been much debate as to the diagnostic efficacy of this test. four factors influence this determination: (1) patient referral biases, (2) the optimal criteria for test interpretation, (3) the technique for performing radionuclide ventriculography, and (4) technical factors. the rol ... | 2002 | 2194040 |
| imaging techniques for assessing pulmonary artery hypertension and right ventricular performance with special reference to copd. | several imaging techniques, both noninvasive and minimally invasive, have now been applied widely for determining cardiovascular performance in patients with chronic respiratory disease, particularly copd. moreover, some of these techniques are useful for evaluating response to therapeutic intervention in these patients. the plain chest radiograph is useful primarily for detecting the presence of pulmonary artery hypertension in patients with copd. radionuclide angiocardiography, using either fi ... | 2002 | 2194041 |
| reversal of cardiogenic shock and asystole in a septic patient with hypertrophic cardiomyopathy on verapamil. | 2008 | 2194748 | |
| [the ability of flea species on the common vole from mountainous dagestan to transmit and preserve the causative agent of plague]. | the infection ability and terms of preservation of plague microbe in fleas of common vole from dagestan high-mountain plague focus (frontopsylla causasica, megabothris turbidus, ctenophthalmus intermedius and amphipsylla rossica) was studied experimentally. block formation and transmission of the infection by f. caucasica and m. turbidus was observed. the transmission of plague microbe by ct. intermedius fleas was first carried out. these species of fleas preserve the infection for a long time. ... | 1990 | 2195439 |
| [the efficiency of rhadinopsylla rothschildi and r. dahurica fleas as vectors of the causative agent of plague in a transbaikal natural focus]. | experiments have shown that a block of proventriculus arises in 2.1 to 12.5% of infected fleas of r. rothschildi and in 7.2 to 10.5% of r. dahurica. these fleas transmit the plague agent to different animals (brandt's vole, narrow-skulled vole, dahurian suslik). the plague microbe is preserved in the organism of infected insects till the end of the experiment, 74 and 24 days respectively. therefore, the fleas can play a part in the maintenance of plague epizootics in the transbaikal natural nidu ... | 1990 | 2195440 |
| association of intracranial meningioma with arteriovenous malformation. | simultaneous occurrence of a cerebral arteriovenous malformation and a primary brain tumor is rare. a case of a left occipital meningioma and a right parietotemporal arteriovenous malformation is reported. clinical, radiological, and postmortem findings are described. thirty previous reports of arteriovenous malformations associated with primary brain tumors are reviewed. in 18 cases the two lesions were intermixed or in close proximity. this spatial relationship between the lesions suggests mor ... | 1999 | 2195683 |
| effectiveness of cis-platin and carboplatin in the chemotherapy of squamous cell carcinoma grown as multicellular spheroids. | we compared cis-platin (ddp) and its analogue, carboplatin (jm8, cbdca) in their ability to inhibit spheroid growth. the activities of ddp and jm8 were also compared in an antimetabolic assay for their ability to inhibit (3h)-thymidine incorporation in multicellular tumor spheroids. the spheroids were derived from a squamous cell carcinoma cell line hn-1, originally derived from a tumor of the tongue. to produce equal levels of growth delay in spheroids, carboplatin was required at concentration ... | 2001 | 2195988 |
| cloning of the yeast sfl2 gene: its disruption results in pleiotropic phenotypes characteristic for tup1 mutants. | we have identified a yeast gene, sfl2 (suppressor gene for flocculation), which complemented a newly isolated sfl2 mutant. this mutation causes asexual cell aggregation. the strain bearing the sfl2 gene disruption exhibited pleiotropic phenotypes characteristic for tup1 mutants. physical mapping and complementation analysis suggested that the cloned sfl2 gene is identical to the tup1 gene. the sfl2 gene encodes a 669-amino acid protein which has domains rich in glutamine, as does the ssn6 protei ... | 1990 | 2197185 |
| [imaging procedures as principle aids in functional surgical therapy of the temporomandibular joint]. | 2006 | 2197195 |