Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [patterns of initial treatment failure of esophageal cancer following radiotherapy]. | sixty patients with stage i-iii esophageal squamous cell cancer treated by definitive radiotherapy (rt) were analyzed for patterns of treatment failure. patients were treated by external rt alone (n = 45) or in combination with intraluminal rt (n = 15) when suitable, with prescribed total doses ranging from 59.4 to 104.4 gy. concurrent chemotherapy consisting of cisplatin and/or 5-fluorouracil was administered to 19 patients. the two-year actuarial survival rate and two-year disease-free surviva ... | 1999 | 10614106 |
| [cervical lymphnode metastasis of early or late t2 tongue carcinoma]. | between 1986 and 1997, 72 patients (47 males, 25 females) with previously untreated tongue cancer were treated at our institution (surgery: 67, interstitial radiotherapy: 3, palliative therapy: 2). these patients, especially t2 tongue cancer, were classified into two groups (early t2: < or = 3 cm, late t2: > 3 cm) according to the maximum diameter of the primary lesion, and were analyzed for treatment outcome and cervical lymphnode metastasis. (1) the cumulative 5-year survival rates were 65.9% ... | 1999 | 10614116 |
| [a case of acute transverse myelopathy and bilateral optic neuritis associated with anticardiolipin antibodies, lupus anticoagulant and perinuclear antineutrophil cytoplasmic antibodies]. | a 69-year-old woman developed paraplegia and hypesthesia on upper extremities and below t4 level. examination of cerebrospinal fluid showed increased protein levels and pleocytosis. mri of the cervical spinal cord revealed syrinx formation from c3 to upper thoracic cord. a diagnosis of acute transverse myelitis was made. a high dose of corticosteroid including pulse therapy did not improve her symptoms and signs of myelopathy, but the syrinx could not be found thereafter. one year later, she dev ... | 1999 | 10614163 |
| developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of rc3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain. | polychlorinated biphenyls (pcbs) are a class of industrial compounds consisting of paired phenyl rings with various degrees of chlorination. they are now ubiquitous, persistent environmental contaminants that are routinely found in samples of human and animal tissues and are known to affect brain development. the effects of pcbs on brain development may be attributable, at least in part, to their ability to reduce circulating levels of thyroid hormone. however, the developmental effects of pcb e ... | 2000 | 10614638 |
| characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. | the type 2 iodothyronine deiodinase (d2) catalyzes t4 activation. in humans, unlike rodents, it is widely expressed, and its action probably contributes to both intracellular and plasma t3 pools. we have isolated the 6.5-kb 5'-flanking region (fr) and the previously uncloned 553 nucleotides (nt) of the 5'-untranslated region (utr) of hdio2. the 5'-utr is complex, with three transcription start sites (tss) (708, 31, and approximately 24 nt 5' to the atg), an alternatively spliced approximately 30 ... | 2000 | 10614643 |
| [economic evaluation od the value of early diagnosis and management of hypothyroidism in hypercholesterolemia]. | the aim of the study was to assess the economic consequences of the early screening and management for overt hypothyrodism in elderly women suffering from hypercholesterolaemia. | 1999 | 10615519 |
| [squamous cell carcinoma of the head and neck and pulmonary cancer. report of 50 cases]. | association of a squamous cell carcinoma of the head and neck and a pulmonary cancer is frequent: prevalence is about 5 to 10 percent. the purpose of this study was to present the survival analysis of 50 patients, previously treated for a squamous cell carcinoma of the head and neck, and then treated for a pulmonary cancer between 1979 and 1996. four patients were excluded from the analysis. five pulmonary cancers were synchronous with the head and neck cancer, 41 were metachronous. metachronous ... | 1999 | 10615525 |
| nutrition, thyroid function and basal metabolism of the evenki of central siberia. | considerable research has shown that indigenous circumpolar populations have elevated basal metabolic rates (bmr). such elevations are likely promoted by changes in thyroid hormone levels; however, to date, this link between thyroid function and variation in bmr has not been explicitly demonstrated in an indigenous northern group. thus, the purpose of this paper is to examine 1) the influence of dietary and nutritional factors on variation in thyroid hormone levels, and 2) the influence of thyro ... | 1999 | 10615833 |
| sensitivity of bacteriophage rb69 dna polymerase to n2-(p-n-butylphenyl)-2'-deoxyguanosine nucleotides. | the response of bacteriophage rb69 dna polymerase to n2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate (bupdgtp), related nucleotides and non-nucleoside inhibitors was measured and compared to values obtained for the closely related dna polymerase from bacteriophage t4. both enzymes showed similar responses to inhibitors in terms of ki values and the ability to utilize bupdgtp as a substrate. these results provide the relevance of using the recent crystal structure of rb69 dna polymerase fo ... | 1999 | 10616725 |
| solid-state synthesis and mechanical unfolding of polymers of t4 lysozyme. | recent advances in single molecule manipulation methods offer a novel approach to investigating the protein folding problem. these studies usually are done on molecules that are naturally organized as linear arrays of globular domains. to extend these techniques to study proteins that normally exist as monomers, we have developed a method of synthesizing polymers of protein molecules in the solid state. by introducing cysteines at locations where bacteriophage t4 lysozyme molecules contact each ... | 2000 | 10618384 |
| post-tetanic count and train-of-four responses during neuromuscular block produced by vecuronium and infusion of nicardipine. | we have examined onset and recovery of neuromuscular block produced by vecuronium using either post-tetanic count (ptc), or the first twitch of the train-of-four (tof) (t1/t0) and tof ratio (t4/t1) during continuous infusion of nicardipine. sixty adult patients were allocated to one of four groups of 15 patients each: nicardipine-ptc, nicardipine-tof, control-ptc and control-tof. in the nicardipine-ptc and nicardipine-tof groups, nicardipine 0.03 mg kg-1 was given before vecuronium 0.1 mg kg-1 a ... | 1999 | 10618956 |
| withania somnifera and bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. | the effects of daily administration of withania somnifera root extract (1.4 g/kg body wt.) and bauhinia purpurea bark extract (2.5 mg/kg body wt.) for 20 days on thyroid function in female mice were investigated. while serum triiodothyronine (t3) and thyroxine (t4) concentrations were increased significantly by bauhinia, withania could enhance only serum t4 concentration. both the plant extracts showed an increase in hepatic glucose-6-phosphatase (g-6-pase) activity and antiperoxidative effects ... | 1999 | 10619390 |
| muscle mass and function in thyrotoxic patients before and during medical treatment. | development of muscle weakness and atrophy are well known complications of thyrotoxicosis, although little is known about its clinical course. the present longitudinal study was therefore undertaken to monitor muscle mass and strength before and during treatment of hyperthyroidism. | 1999 | 10619973 |
| initial characterization of the gh-igf axis and nutritional status of the ati negritos of the philippines. | the ati negritos are a pygmy-like aboriginal population from the philippines with physical characteristics of short stature, dark skin and woolly, kinked hair. their final height, components of their gh-igf axis and various nutritional markers are described. subjects, design and measurements: auxological data and sera for the components of the gh-igf axis and nutritional parameters were collected from 9 adult ati negritos in their native environment and 10 filipinos in sydney. | 1999 | 10619979 |
| detection of a peripheral blood t cell clone is an independent prognostic marker in mycosis fungoides. | t cell receptor gene analysis is a sensitive method for assessment of peripheral blood involvement in mycosis fungoides. this study uses polymerase chain reaction/single-strand conformational polymorphism (pcr/sscp) analysis of the t cell receptor gamma gene and relates the results to skin stage and outcome in mycosis fungoides. seventy-five peripheral blood samples from 66 patients were obtained from 1990 onwards and subjected to pcr/sscp. both southern blot analysis and pcr/sscp analysis were ... | 2000 | 10620126 |
| topical treatment with liposomes containing t4 endonuclease v protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-alpha. | exposing human skin to ultraviolet radiation causes dna damage, sunburn, immune alterations, and eventually, skin cancer. we wished to determine whether liposomes containing a dna repair enzyme could prevent any of the acute effects of irradiation when applied after ultraviolet exposure. fifteen human patients with a prior history of skin cancer were exposed to two minimal erythema doses of ultraviolet radiation on their buttock skin. liposomes containing t4 endonuclease v or heat-inactivated en ... | 2000 | 10620131 |
| a trial of thyroxine in acute renal failure. | a trial of thyroxine in acute renal failure. | 2000 | 10620211 |
| the introduction of strain and its effects on the structure and stability of t4 lysozyme. | in order to try to better understand the role played by strain in the structure and stability of a protein a series of "small-to-large" mutations was made within the core of t4 lysozyme. three different alanine residues, one involved in backbone contacts, one in side-chain contacts, and the third adjacent to a small cavity, were each replaced with subsets of the larger residues, val, leu, ile, met, phe and trp. as expected, the protein is progressively destabilized as the size of the introduced ... | 2000 | 10623513 |
| active-site determination of a pyrimidine dimer glycosylase. | one mechanism for the repair of uv-induced dna damage is the base excision repair pathway. the initial step in this pathway and the specificity for the type of damage that is to be repaired reside in dna glycosylase/abasic (ap) lyases. cleavage of the glycosyl bond of the 5' pyrimidine of a cyclobutane pyrimidine dimer is hypothesized to occur through the destabilization of the glycosyl bond by protonation of the base or sugar with a concomitant nucleophilic attack on c1' of the deoxyribose moie ... | 2000 | 10623540 |
| is radiation therapy a preferred alternative to surgery for squamous cell carcinoma of the base of tongue? | to evaluate irradiation alone for treatment of base-of-tongue cancer. | 2000 | 10623691 |
| widespread distribution of a group i intron and its three deletion derivatives in the lysin gene of streptococcus thermophilus bacteriophages. | of 62 streptococcus thermophilus bacteriophages isolated from various ecological settings, half contain a lysin gene interrupted by a group ia2 intron. phage mrna splicing was demonstrated. five phages possess a variant form of the intron resulting from three distinct deletion events located in the intron-harbored open reading frame (orf 253). the predicted orf 253 gene sequence showed a significantly lower gc content than the surrounding intron and lysin gene sequences, and the predicted protei ... | 2000 | 10623722 |
| mri of local disease in nasopharyngeal carcinoma: tumour extent vs tumour stage. | the purpose was to use mri to study in detail local tumour extension in patients presenting with nasopharyngeal carcinoma (npc) and to compare the extent of local disease with the current t-stage classification. mr images of 150 patients with newly diagnosed nasopharyngeal carcinoma were obtained on a 1.5 t unit. 10 extranasopharyngeal sites were analysed for tumour involvement. the number of concurrently involved sites was determined. the extent of tumour invasion was compared with staging as d ... | 1999 | 10624338 |
| comparisons of pressure and temperature activation parameters for amide hydrogen exchange in t4 lysozyme. | activation enthalpies and entropies are reported for proton-deuteron exchange at 42 amide sites in t4 lysozyme and compared with activation volumes for the same residues obtained earlier [hitchens, t. k., and bryant, r. g. (1998) biochemistry 37, 5878-5887]. there is no correlation found between activation volume and activation entropy or activation enthalpy. the activation enthalpy is linearly related to the activation entropy in part as a consequence of a relatively narrow sampling window for ... | 2000 | 10625500 |
| purification and characterization of the trna-processing enzyme rnase bn. | rnase bn, a trna-processing enzyme previously shown to be required for the 3'-maturation of certain bacteriophage t4-encoded trnas, was overexpressed and purified to near homogeneity from escherichia coli. the purified enzyme, which is free of nucleic acid, is an alpha(2)-dimer with a molecular mass of approximately 65 kda. rnase bn displays a number of unusual catalytic properties compared with the other exoribonucleases of e. coli. the enzyme is most active at ph 6.5 in the presence of co(2+) ... | 2000 | 10625642 |
| cardiovascular responses to intrathecal dopamine receptor agonists in conscious doca-salt hypertensive rats. | previous studies have demonstrated that in conscious deoxycorticosterone acetate (doca)-salt hypertensive rats, the hypotensive action of intravenous (i.v.) bromocriptine, a selective dopamine d2 receptor agonist, was mediated partly by peripheral and partly by spinal dopamine d2 receptor stimulation, and that this effect was greater and longer-lasting than that in uninephrectomized control rats. to determine whether this amplification results partly from a putative spinal hypersensitivity pheno ... | 1999 | 10626749 |
| the phototumorigenic fluoroquinolone lomefloxacin photosensitizes pyrimidine dimer formation in human keratinocytes in vitro. | the fluoroquinolone antibiotic lomefloxacin is phototoxic, photogenotoxic, photomutagenic and photosensitizes tumorigenesis in mouse skin. we have used t4 endonuclease v to demonstrate that lomefloxacin photosensitizes pyrimidine dimer formation in a human keratinocyte line (hacat). a possible mechanism for this effect would be triplet-triplet energy transfer. however, there is indirect evidence that the lomefloxacin triplet yield is very low, making this reaction less likely. the finding that l ... | 1999 | 10628309 |
| neuroendocrine responses following graded traumatic brain injury in male adults. | in an effort to characterize thyroid, gonadal and adrenal function following neurotrauma, the present study determined serum concentrations of thyroid-stimulating hormone (tsh), total triiodothyronine (t3), thyroxine (t4), testosterone and cortisol over a 7 day period in 31 patients with traumatic brain injury. the study group consisted of eight patients with mild closed head injury (glasgow coma scale--gcs 13-15), 10 patients with extensive penetrating head injury (gcs 4-6) and 13 patients with ... | 1999 | 10628505 |
| [controversies in the new tnm staging system]. | the latest revision of the international system for staging lung cancer was published in june 1997. we discuss the following 4 major items in the new tnm staging system. 1) the fact that stage i was divided into stage ia (t1n0m0) and ib (t2n0m0) is reasonable, as the survival prospects for the subsets differ significantly. 2) the fact that stage ii was divided into stage iia (t1n1m0) and iib (t2n1m0) is not appropriate, however, there is no significant survival difference between the t1n1m0 subs ... | 1999 | 10629834 |
| [the prevalence of thyroid functional disorders in the province of lleida]. | to assess the prevalence of thyroidal disorders in our area using a representative sample of the population in terms of age and distribution by sex. | 1999 | 10630030 |
| [conservative treatment of anal canal carcinoma with external radiotherapy and interstitial brachytherapy, with or without chemotherapy: long-term results]. | a retrospective analysis of conservative treatment of anal canal cancers with external radiation therapy and interstitial brachytherapy with or without chemotherapy. | 1999 | 10630158 |
| enhanced chemotaxis of macrophages by strenuous exercise in trained mice: thyroid hormones as possible mediators. | exercise modulates the macrophage activity via 'stress hormones'. three experiments were performed. (1) the effect of strenuous exercise performed by trained mice on macrophage chemotactic capacity was evaluated; (2) peritoneal macrophages from control mice were incubated with plasma from exercised mice or control mice and the differences in chemotaxis were measured; (3) changes in plasma t3 and t4 levels after exercise were measured, and the effect of incubation with the post-exercise levels of ... | 1999 | 10630621 |
| evaluation of antioxidant status in liver tissues: effect of iron supplementation in experimental hyperthyroidism. | the antioxidant defense system in liver tissue in experimental hyperthyroidism and/or in iron supplementation was investigated. thyroid hormones (t3, t4, tsh), ferritin (marker of iron status), antioxidant status components (glutathione [gsh], glutathione peroxidase [gsh-px], superoxide dismutase [sod]), and serum transaminases (got and gpt, both of which are known to be released from damaged hepatocytes), were measured. hyperthyroidism in rats, induced by l-thyroxine administration, significant ... | 1999 | 10631595 |
| thyroid function and effects on reproduction in ewes exposed to the organochlorine pesticides lindane or pentachlorophenol (pcp) from conception. | there is concern over the potential endocrine-modulating effects of long-term exposure to pesticides. in this study, ewe lambs were exposed to lindane and pentachlorophenol (pcp) from conception to necropsy at 67 wk. of age. the ewe lambs (and their mothers) were given untreated feed (n = 6) or feed treated with 1 mg/kg body weight/day of lindane (n = 8) or pcp (n = 13). estrus was synchronized at 32 wk. of age, and ewe lambs were exposed to vasectomized rams. ewe lambs were then exposed to inta ... | 1999 | 10632142 |
| retromolar trigone tumors: evaluation by magnetic resonance imaging and correlation with pathological data. | the aim of this study was to evaluate the diagnostic accuracy of magnetic resonance (mr) images to establish both the t stage and the relationships between the tumors and the surrounding structures in retromolar trigone tumors. twenty-two patients with squamous cell carcinoma of the retromolar trigone were examined by mr with a superconductive scanner operating at 1.5t. the study was performed with spin-echo (se) t1 and t2 and short se t1 sequences (tr 180 ms, te 15 ms) after the administration ... | 1999 | 10632555 |
| bacteriophage t4 self-assembly: in vitro reconstitution of recombinant gp2 into infectious phage. | t4 gene 2 mutants have a pleiotropic phenotype: degradation of injected phage dna by exonuclease v (exov) in the recbcd(+) host cell cytoplasm and a low burst size due, at least in part, to a decreased ability for head-to-tail (h-t) joining. the more n terminal the mutation, the more pronounced is the h-t joining defect. we have overexpressed and purified the recombinant gene 2 product (rgp2) to homogeneity in order to test its role in h-t joining, during in vitro reconstitution. when we mix ext ... | 2000 | 10633100 |
| bacteriophage t4 self-assembly: localization of gp3 and its role in determining tail length. | gene 3 of bacteriophage t4 participates at a late stage in the t4 tail assembly pathway, but the hypothetical protein product, gp3, has never been identified in extracts of infected cells or in any tail assembly intermediate. in order to overcome this difficulty, we expressed gp3 in a high-efficiency plasmid expression vector and subsequently purified it for further analysis. the n-terminal sequence of the purified protein showed that the initial methionine had been removed. variant c-terminal a ... | 2000 | 10633101 |
| p27 cell-cycle inhibitor is inversely correlated with lymph node metastases in right-sided colon cancer. | p27, a cyclin-dependent kinase inhibitor, suppresses proliferation of normal and neoplastic cells. expression of p27 is correlated with survival in colon cancer. to some degree, right-sided colon cancers differ biologically and clinically from left-sided colon cancers. we analyzed 41 patients with right-sided colon cancers, including 18 cases with regional lymph node metastases and 23 cases with negative lymph nodes. immunostaining for p27 was performed on histologic sections of primary cancers ... | 1999 | 10633297 |
| overexpression, purification, and partial characterization of adp-ribosyltransferases moda and modb of bacteriophage t4. | there is increasing experimental evidence that adp-ribosylation of host proteins is an important means to regulate gene expression of bacteriophage t4. surprisingly, this phage codes for three different adp-ribosyltransferases, gene products alt, moda, and modb, modifying partially overlapping sets of host proteins. while gene product alt already has been isolated as a recombinant protein and its action on host rna polymerases and transcription regulation have been studied, the nucleotide sequen ... | 1999 | 10634320 |
| physiologic fluctuations of serum estradiol levels influence biochemical markers of bone resorption in young women. | we investigated the effect of physiologic variations in sex hormone levels during the menstrual cycle on biomarkers of bone turnover. blood and 24-h and fasting urine samples were obtained in nine women (age, 25.1+/-3.0 yr) with regular menstrual cycles during the early follicular period (t1), 3 days before ovulation (t2), 3 days after ovulation (t3), at the midluteal period (t4) and again during the early follicular period of the next cycle (t5). all subjects had a calcium intake covering curre ... | 2000 | 10634371 |
| cardiac function, physical exercise capacity, and quality of life during long-term thyrotropin-suppressive therapy with levothyroxine: effect of individual dose tailoring. | as recently claimed, tsh-suppressive therapy with l-t4 may have adverse effects on the heart, but these results have not been consistently confirmed. we assessed cardiac function by clinical, echocardiographic, and ergometabolic criteria in 19 patients (16 women and 3 men) receiving long term l-t4 at a fixed daily dose ranging from 1.8-4.0 microg/kg. the results showed significant alterations in several cardiac parameters suggestive of subclinical hyperthyroidism. in particular, intraventricular ... | 2000 | 10634380 |
| is diagnostic iodine-131 scanning useful after total thyroid ablation for differentiated thyroid cancer? | a diagnostic iodine-131 (131i) total body scan (tbs) is usually recommended 6 to 12 months after thyroid ablation for differentiated thyroid carcinoma. its usefulness was evaluated in 256 consecutive patients treated and followed up at the institut gustave roussy for papillary (n = 200), well differentiated (n = 27), or poorly differentiated (n = 29) follicular thyroid carcinomas. all patients underwent a near-total or total thyroidectomy and 131i ablation with 3.7 gbq (100 mci). no tbs was perf ... | 2000 | 10634383 |
| identification of thyroxine-binding globulin-san diego in a family from houston and its characterization by in vitro expression using xenopus oocytes. | t4-binding globulin (tbg) is a liver glycoprotein that transports iodothyronines in serum. several tbg variants with reduced t4 binding affinity have been described, all of which are also characterized by reduced serum tbg concentrations and reduced heat stability. their loss of binding thus appears to be due to a general defect of the molecule. we now report the occurrence of a variant tbg, detected in a family from houston, tx, with half the normal t4 binding affinity and heat stability but no ... | 2000 | 10634412 |
| neonatal hypoglycaemia in nepal 2. availability of alternative fuels. | to study early neonatal metabolic adaptation in a hospital population of neonates in nepal. | 2000 | 10634843 |
| [thyroid hormone resistance syndromes: clinical aspects]. | introduction: syndromes of resistance to thyroid hormone correspond to variable clinical states which are usually transmitted as autosomal dominant traits and characterized by the lack of sensitivity of target tissues to triiodothyronine (t3). the diagnosis has to be performed in order to offer an appropriate therapy. current knowledge and key points: clinical states range between two extremes: the generalized form, with global euthyroidism, and the predominantly pituitary form, with thyrotoxico ... | 1999 | 10635073 |
| conservation surgery for laryngeal and hypopharyngeal cancer. | the charts of 173 patients treated by conservation laryngectomy and pharyngolaryngectomy were retrospectively reviewed. the patients treated by endoscopic laser resection were excluded of this study. glottic carcinoma was diagnosed in 101 patients, supraglottic carcinoma in 44 patients, hypopharyngeal carcinoma in 24 patients and oropharyngeal carcinoma in 4 patients. the median follow-up period was 44 months, 84/101 glottic cancer, 34/44 supraglottic cancer, 23/24 hypopharyngeal cancer and 2/4 ... | 1999 | 10635394 |
| current and potential chemotherapeutic agents used for induction chemotherapy in the treatment of breast cancer. | a substantial proportion of breast cancers are large (<3 cm) or locally advanced (t3, t4, txn2) at the time of initial presentation. the therapeutic goals that must be achieved in patients with such cancers are to obtain adequate local disease control so that surgery can be performed and to abolish occult distant metastases therefore improving survival. over the past three decades conventional adjuvant chemotherapy regimens have been employed pre-operatively (neo-adjuvant or primary chemotherapy ... | 2000 | 10637382 |
| [simultaneous presentation of actinomycosis and metastatic pharyngeal carcinoma]. | although actinomycosis frequently presents as a pseudotumoral syndrome, the simultaneous diagnosis of actinomycosis and cancer is exceptional. actinomycosis can occur as an opportunistic infection secondary to the antineoplastic treatment and even the cancer itself can act as facilitating factor. we report a patient who was diagnosed simultaneously of advanced oropharinx cancer (t4-n1-m0) and actinomycosis associated to the tumoral mass. this exceptional association and the importance of its ear ... | 1999 | 10638002 |
| physicochemical stability of two types of intravenous lipid emulsion as total nutrient admixtures. | recent data have demonstrated that total nutrient admixtures (tnas) are unstable when the percentage of fat (pfat) globules >5 microm in diameter constitute >0.4% of the total fat present and therefore can be considered pharmaceutically unfit for human administration. | 2000 | 10638467 |
| effectiveness of physiotherapy after meniscectomy. | to evaluate the effect of physiotherapy after partial arthroscopic meniscectomy, we performed a prospective, randomised and partially blinded study. this pilot study was performed from october 1996 to june 1997. the control group received the standard treatment, consisting of verbal and written advice and exercises. the physiotherapy group performed exercises according to a dynamic protocol under the supervision of a physiotherapist. during a 3-week period, nine treatment sessions were given of ... | 1999 | 10639654 |
| evaluation of thyroid hormones in chronic renal failure. | when chronic renal failure becomes advanced, the serum levels of most hormones are altered because of several interplaying mechanisms. this study was carried out to evaluate the level of total thyroxine (t4), triiodothyronine (t3) and thyrotropin (tsh) in 96 clinically euthyriod patient with chronic renal failure and 25 healthy individual as control. the patients were grouped into two groups, 62 patient on conservative management and 34 patients on chronic haemodialysis. the patient of both grou ... | 1999 | 10639771 |
| age-related variation in the treatment and outcomes of patients with breast carcinoma. | there is controversy regarding the effect of age on breast carcinoma, and previous analyses have often excluded the most elderly patients as well as those with advanced cancers. this study assessed treatment variations and outcome in relation to age for a complete series of patients who presented with breast carcinoma within a defined geographic district. | 2000 | 10640970 |
| nasopharyngeal carcinoma in children under 15 years of age: a retrospective review of 65 patients. | nasopharyngeal carcinoma constitutes comprises up to 5% of primary childhood cancers but literature lacks modern uniformly treated large series. | 1999 | 10643543 |
| parenteral selenium supplementation in extremely low birth weight infants: inadequate dosage but no correlation with hypothyroidism. | selenium is an essential trace element, known to be important in thyroid metabolism. we speculated that parenteral selenium supplementation is inadequate in preterm infants and may contribute to the development of hypothyroidism. | 1999 | 10645521 |
| improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone. | we report an improved heterologous radioimmunoassay (ria) for the measurement of thyrotropin (tsh) in mouse serum. the assay components are: antirat thyrotropin (rtsh) serum from the national hormone and pituitary program, a commercial [125i]-labeled rtsh and mouse thyrotropin (mtsh) serum standards produced by dilution of a serum pool from hypothyroid mice with high tsh with a serum pool from mice treated with excess levothyroxine (lt4) (mtsh-0). sensitivity was increased by reducing the amount ... | 1999 | 10646670 |
| acanthamoeba strains isolated from organs of freshwater fishes. | contrary to data on acanthamoeba infections in humans, little is known about infections in fishes. the present study combines the description of strains isolated from fishes with presentation of an improved method for subgeneric classification. acanthamoeba spp. were isolated aseptically from tissues of 14 (1.7%) of 833 asymptomatic fishes collected in rivers and streams in the czech republic. acanthamoebae successfully cloned from 10 of the 14 isolated strains were examined here. morphology of ... | 1999 | 10647044 |
| is adrenalectomy a necessary component of radical nephrectomy? ucla experience with 511 radical nephrectomies. | we determine the incidence and characteristics of adrenal involvement in localized and advanced renal cell carcinoma, and evaluate the role of adrenalectomy as part of radical nephrectomy. | 2000 | 10647649 |
| neural network analysis of clinicopathological and molecular markers in bladder cancer. | to evaluate retrospectively the ability of an artificial neural network (ann) to predict bladder cancer recurrence within 6 months of diagnosis and stage progression in patients with ta/t1 bladder cancer, and 12-month cancer-specific survival in patients with t2-t4 bladder cancer. | 2000 | 10647699 |
| disclosing subclinical thyroid disease. an approach to mild laboratory abnormalities and vague or absent symptoms. | patients with subclinical thyroid disease often have no apparent symptoms or only nonspecific complaints. however, increasing evidence that early disease is associated with behavioral, psychiatric, biochemical, and organ-specific abnormalities has led several specialty organizations to publish or modify position papers. serum tsh testing is the most sensitive method of identifying early thyroid dysfunction. it should be considered in patients who have risk factors for mild thyroid failure, have ... | 2000 | 10649671 |
| vertebral scale system to measure heart size in radiographs of cats. | to determine absolute and relative heart size in clinically normal cats by correlating heart size and selected skeletal structures. | 2000 | 10649755 |
| intron conservation in a uv-specific dna repair gene encoded by chlorella viruses. | large dsdna-containing chlorella viruses encode a pyrimidine dimer-specific glycosylase (pdg) that initiates repair of uv-induced pyrimidine dimers. the pdg enzyme is a homologue of the bacteriophage t4-encoded endonuclease v. the pdg gene was cloned and sequenced from 42 chlorella viruses isolated over a 12-year period from diverse geographic regions. surprisingly, the pdg gene from 15 of these 42 viruses contain a 98-nucleotide intron that is 100% conserved among the viruses and another 4 viru ... | 2000 | 10654262 |
| hyperthyroidism after surgery for primary hyperparathyroidism. | the coexistence of hyperthyroidism and primary hyperparathyroidism (phpt) has been reported. we have questioned whether hypercalcemia or surgical trauma contribute to transient hyperthyroidism following parathyroid surgery. | 1999 | 10654273 |
| effect of lithium on thyroidal 131iodine uptake, its clearance, and circulating levels of triiodothyronine and thyroxine in lead-treated rats. | the influence of lead acetate (50 mg per kg body weight) on the 131iodine (131i) biokinetics (uptake and retention) in rat thyroid and serum levels of triiodothyronine (t3) as well as thyroxine (t4) was evaluated as a function of time and in combination with lithium treatment. the 2-h and 24-h uptake of 131i in the thyroid was stimulated significantly by lead treatment. the 24-h uptake showed a maximum stimulation after 4 months of lead treatment. lithium supplementation, however, showed the opp ... | 1999 | 10654347 |
| extended resections for bronchogenic carcinoma invading the superior vena cava system. | extended resection of non-small-cell lung cancer (nsclc) involving the superior vena cava (svc) system is infrequently performed and oncologic benefits are still uncertain. | 2000 | 10654520 |
| smoking and alcohol use may be risk factors for poorer outcome in patients with clear cell renal carcinoma. | to correlate the clinical outcomes of 148 patients with clear cell renal carcinoma treated at a single institution with a variety of other factors. | 2000 | 10654890 |
| augmentation of vecuronium-induced neuromuscular block during sevoflurane anaesthesia: comparison with balanced anaesthesia using propofol or midazolam. | we have quantified the potentiating effects of 1.7% sevoflurane (n = 12) on vecuronium-induced neuromuscular block and compared the results with those obtained during balanced anaesthesia with propofol (n = 12) or midazolam (n = 12) in 36 patients. neuromuscular function was monitored using an accelerograph and the train-of-four responses of the adductor pollicis muscle to ulnar nerve stimulation. vecuronium 0.1 mg kg-1 was administered as an intubating dose, and maintenance doses of 0.02 mg kg- ... | 1999 | 10655928 |
| [seasonal changes in the triiodothyronine level of the blood evoked by ultraviolet irradiation in vitro]. | ultraviolet irradiation (lambda = 254 nm) of the whole blood of juvenile bulls in vitro results in a plasmatic t3 increase dependent on the time of exposure. dynamics of the growth of hormone content because of uv varies with season. no negative correlation between plasmatic t3 and t4 in irradiated and non-irradiated blood samples was stated. hence, increased t3 levels in blood after uv irradiation in vitro is a consequence of the output of erythrocyte-deposited hormone rather than photoactivati ... | 1999 | 10656136 |
| ability of baclofen in reducing alcohol craving and intake: ii--preliminary clinical evidence. | accumulating evidence shows the efficacy of the gamma-aminobutyric acid (gaba(b)) receptor agonist baclofen in reducing alcohol intake in rats, but no studies have been performed in alcoholics. in the present preliminary study we investigated the effect of short-term baclofen administration on craving for alcohol, ethanol intake, and abstinence from alcohol in alcoholic individuals. | 2000 | 10656195 |
| continuum electrostatic analysis of preferred solvation sites around proteins in solution. | to understand water-protein interactions in solution, the electrostatic field is calculated by solving the poisson-boltzmann equation, and the free energy surface of water is mapped by translating and rotating an explicit water molecule around the protein. the calculation is applied to t4 lysozyme with data available on the conservation of solvent binding sites in 18 crystallographically independent molecules. the free energy maps around the ordered water sites provide information on the relatio ... | 2000 | 10656264 |
| prognostic significance of tissue prostate-specific antigen in endocrine-treated prostate carcinomas. | fine-needle aspiration biopsy is a minimally invasive technique for obtaining sample material suitable not only for cytological grading but also for flow cytometry and for biochemical analyses. the prognostic value of tissue prostate-specific antigen (t-psa) from fine-needle aspiration biopsies was compared with serum total and free prostate-specific antigen, the ratio of free:total serum prostate-specific antigen, tumor stage, cytological grade, and dna ploidy in 179 patients with stage t2-t4 p ... | 2000 | 10656445 |
| repeat transthoracic endoscopic sympathectomy for palmar and axillary hyperhidrosis. | patients undergoing an unsuccessful sympathectomy experience dryness on one hand and excessive sweating on the other. this is embarrassing for the patients, and resolution of both a previous failed sympathectomy and recurrent hyperhidrosis is important. | 2000 | 10656945 |
| surgery for advanced stage lung cancer. | therapeutic strategy in advanced stage disease remains controversial. theoretically resectable, stage iiia disease includes a high proportion of non-resectable nodal diseases. overall 5-year survival after surgery remains lower than 15%. randomized trials comparing the results of surgery alone with induction chemotherapy followed by surgery showed a significant benefit to induction therapy. currently, stage iiib diseases are considered unresectable; nevertheless, selected patients are able to un ... | 2000 | 10657915 |
| the management of superior sulcus tumors. | lung cancers arising from the extreme apex of the lung-superior sulcus tumors (sst)-have distinct symptoms and signs at presentation and a characteristic appearance on imaging. however, in their early stages, these tumors are often missed by traditional anterior/posterior chest x-rays. recent advances in computed tomography (ct) and magnetic resonance imaging (mri) have made selection of patients with potentially resectable of sst more accurate. if mediastinoscopy reveals no mediastinal lymph no ... | 2000 | 10657917 |
| the effect of diet composition and feeding state on the response to exercise in feed-restricted horses. | eight thoroughbred horses were used to determine the effects of long-term calorie restriction and diet composition on serum t4 and t3 concentrations and metabolic responses with exercise. horses were randomly assigned to 2 treatment groups (n = 4): group 1, horses were fed a calorie-restricted diet designed to have 70% of the calories from the roughage source (rhr); group 2, horses were fed a calorie-restricted diet designed to have 70% of the calories from the concentrate source (rhc). horses t ... | 1999 | 10659310 |
| exertional rhabdomyolysis in quarter horses and thoroughbreds: one syndrome, multiple aetiologies. | the purpose of this study was to determine if chronic exertional rhabdomyolysis (er) in quarter horses and thoroughbreds represents one or several distinct myopathies. eighteen quarter horses and 18 thoroughbreds with er were selected from cases presented to the veterinary hospital on the basis of a history of er, assessment of muscle histopathology, and serum ck activity before and 4 h post exercise. in addition, 2 of 3 of the following parameters were evaluated: muscle glycogen concentrations, ... | 1999 | 10659313 |
| photodynamic therapy for residual or recurrent cancer of the nasopharynx. | adequate or effective treatments are not always available for most recurrent or residual nasopharyngeal cancers (npc). photodynamic therapy (pdt) using hematoporphyrin derivative (hpd) was evaluated for its effectiveness in treating patients, who conventionally failed, with curative or palliative intent. thirteen patients were treated from march 1994 to november 1998. pdt was given to eradicate tumor cells, debulk tumor mass for other treatment options, and to resolve obstruction. long-term tumo ... | 1999 | 10659546 |
| knee kinetics during functional electrical stimulation induced cycling in subjects with spinal cord injury: a preliminary study. | the purpose of this preliminary study was to describe pedal effectiveness parameters and knee-joint reaction forces generated by subjects with chronic spinal cord injury (sci) during functional electrical stimulation (fes)-induced bicycling. three male subjects (age 33-36 years old), who were post-traumatic sci (asia-modified level a, level t4-c5) and enrolled in an fes rehabilitation program, signed informed consent forms and participated in this study. kinematic data and pedal forces during bi ... | 1999 | 10659804 |
| rad51 uses one mechanism to drive dna strand exchange in both directions. | the rad51 protein of saccharomyces cerevisiae, like its bacterial counterpart reca, promotes strand exchange between circular single-stranded dna (ssdna) and linear double-stranded dna (dsdna) in vitro. however, the two proteins differ in the requirement for initiating joint molecules and in the polarity of branch migration. whereas reca initiates joint molecules from any type of ends on the dsdna and branch migration proceeds exclusively in the 5'- to 3'-direction with respect to the single str ... | 2000 | 10660552 |
| activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. | to determine whether cytokine release or activation of the hypothalamo-pituitary-adrenal (hpa) axis is predominantly involved in the development of the euthyroid sick syndrome (ess). | 1999 | 10660848 |
| effect of time interval between breast-conserving surgery and radiation therapy on ipsilateral breast recurrence. | to examine the effect of the time interval (interval) between breast-conserving surgery (bcs) and the start of radiation therapy (rt) on the subsequent risk of ipsilateral breast cancer recurrence (ibr). | 2000 | 10661343 |
| limited value of zinc protoporphyrin as a marker of iron status in chronic hemodialysis patients. | in an attempt to find new parameters able to evaluate the actual iron availability by bone marrow cells, zinc protoporphyrin (znpp), a metabolic intermediate generated in the red blood cell by the incorporation of zinc instead of iron, has been proposed. znpp is a good marker of iron-deficiency anemia in non-uremic people, as red blood cell znpp concentration rises specifically (except for lead intoxication) in this condition. existing data on znpp as a marker of iron deficiency in uremic patien ... | 2000 | 10661481 |
| temperature and kclo(4)-induced metamorphosis in the sea lamprey (petromyzon marinus). | larval sea lampreys (petromyzon marinus) were exposed to either a warm (18 degrees c) or a cold (3 degrees c) water temperature and either with (treated) or without (untreated) the presence of potassium perchlorate (kclo4). after 23 weeks, larvae were examined for signs of metamorphosis and serum samples were collected to assay thyroxine (t4) and 3,5,3'-triiodothyronine (t3) concentrations. water temperature did not significantly affect serum t4 or t3 concentrations in untreated larvae and no me ... | 1999 | 10661717 |
| bta test is superior to voided urine cytology in detecting malignant bladder tumours. | in a prospective study, bard bta (bladder tumour antigen) test was compared to voided urine cytology (vuc) in detecting primary and recurrent bladder cancer (bc). | 1999 | 10661829 |
| alpha-melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. | the hypothalamic arcuate nucleus has an essential role in mediating the homeostatic responses of the thyroid axis to fasting by altering the sensitivity of prothyrotropin-releasing hormone (pro-trh) gene expression in the paraventricular nucleus (pvn) to feedback regulation by thyroid hormone. because agouti-related protein (agrp), a leptin-regulated, arcuate nucleus-derived peptide with alpha-msh antagonist activity, is contained in axon terminals that terminate on trh neurons in the pvn, we ra ... | 2000 | 10662844 |
| influence of age and sex on vertebral shape indices assessed by radiographic morphometry. | vertebral shape indices (vsi) assessed by radiographic morphometry are currently used to define vertebral fractures in clinical trials and epidemiologic studies on osteoporosis. however, there is little information concerning the influence of sex or age on vsi. furthermore, previous reports on the variation of vsi with age showed conflicting results. the aim of this study was to assess the influence of sex and age on vsi in order to better define reference values for the clinical and epidemiolog ... | 1999 | 10663344 |
| altered response to thyroid hormones by prostate and breast cancer cells. | transferrin, an abundant bone marrow constituent, has been shown to be a potent mitogen in vitro in the prostate cancer cell line pc3. t4 (l-thyroxine) and t3 (3',3,5-tri-iodo-l-thyronine) are regulators of cell metabolism. in this study, the effects of nonphysiological concentrations (about two orders of magnitude higher) of t4, t3, t2 (3,5-di-iodo-l-thyronine), rt3 (reverse t3, 3',5', 3-tri-iodo-l-thyronine) and transferrin (about three orders of magnitude lower) were tested on the prostate ca ... | 2000 | 10663623 |
| anticodon nucleases. | a trnalys-specific anticodon nuclease is kept in a latent form in a rare escherichia coli strain, complexed with a dna restriction enzyme. a phage t4 inhibitor of dna restriction activates anticodon nuclease, but other t4 proteins restore trnalys. detection of a homologous system in neisseria and a different anticodon nuclease in colicin e5 suggest ubiquity and diversity of such trna toxins. analysis of these systems could reveal novel rna recognition and cleavage mechanisms. | 2000 | 10664586 |
| grading and staging of bladder carcinoma in transurethral resection specimens. correlation with 105 matched cystectomy specimens. | we compared the grading and staging of transurethral resection of the bladder (turb) and cystectomy specimens for 105 patients who underwent radical cystectomy for urothelial carcinoma between 1980 and 1984. of 105 patients, 96% underwent cystectomy within 100 days of turb (median interval, 10 days). grading was performed according to the 1998 world health organization/international society of urologic pathology grading system and staging according to the 1997 tnm classification. histologic grad ... | 2000 | 10664630 |
| cell viability and protein turnover in nongrowing bacillus megaterium at sporulation suppressing temperature. | in bacillus megaterium, a temperature that suppresses sporulation (43 degrees c) only slightly exceeds both the optimum growth temperature and the temperature still permitting sporulation (40-41 degrees c). here we show that, when cells grown at 35 degrees c and transferred to a sporulation medium, were subjected to shifts between 35 degrees c and the sporulation suppressing temperature (sst, 43 degrees c), their development and proteolytic activities were deeply affected. during the reversible ... | 1999 | 10664882 |
| radiation therapy and concurrent cisplatin in management of locoregionally advanced nasopharyngeal carcinomas. | radiation therapy in combination with chemotherapy in the management of locoregionally advanced nasopharyngeal carcinomas is evaluated in an attempt to improve locoregional response, reduce locoregional failure and reduce systemic failure. the current study was designed to investigate radiation therapy and concurrent cisplatin in this context. from 1992 through 1997, 70 patients with locoregionally advanced nasopharyngeal carcinomas were treated with radiation therapy and concurrent cisplatin. e ... | 1999 | 10665758 |
| effects of tranylcypromine on thyroid hormone metabolism and concentrations in rat brain. | the effect of 14 days administration of the anti-depressant tranylcypromine (tcp) on iodothyronine deiodinase activities and the concentrations of thyroxine (t4) and triiodothyronine (t3) were investigated in homogenates of up to nine regions of the rat brain. the activity of the 5iii deiodinase isoenzyme, which catalyses the inactivation of t3 to 3,3'-diiodothyronine (3,3'-t2), was enhanced in eight brain regions. however, the brain levels of t4 were completely unchanged and the t3 concentratio ... | 2000 | 10665823 |
| use of differentially substituted selenomethionine proteins in x-ray structure determination. | using heavily methionine-substituted t4 lysozyme as an example, it is shown how the addition or deletion of a small number of methionines can simplify the location of selenium sites for use in mad phasing. by comparing the x-ray data for a large number of singly substituted lysozymes, it is shown that the optimal amino acid to be substituted by methionine is leucine, followed, in order of preference, by phenylalanine, isoleucine and valine. the identification of leucine as the first choice agree ... | 1999 | 10666571 |
| crystallization and preliminary x-ray analysis of a bacteriophage t4 primase fragment. | the primase from bacteriophage t4 is a single-stranded dna-dependent rna polymerase that is one of the seven proteins that constitute the dna-replication machinery of bacteriophage t4. in an attempt to crystallize the protein, a number of variants were generated. one such construct, which includes the c-terminal region (residues 196-340), gave four different crystal forms which diffract in the 3. 5-6.0 a resolution range. | 2000 | 10666640 |
| a comparison study of two therapeutic protocols for neurosyphilis. | in morocco, neurosyphilis is a serious public health problem. in the neurology service at the specialist hospital in rabat, two drug treatments were used. treatment a consisted of infusion over a period of 4 h of 20 mui of penicillin g per day for 3 weeks. treatment b consisted of infusion over a period of 6 h of 30 mui of penicillin g per day for 10 days. each treatment was tested on a group of eight neurosyphilitic patients as first-line treatment. on the first day of treatment, both blood and ... | 1999 | 10667099 |
| primary tumors and mediastinal lymph nodes after neoadjuvant concurrent chemoradiotherapy of lung cancer: serial ct findings with pathologic correlation. | the purpose of this work was to describe the changes of primary tumor and mediastinal lymph nodes on ct after neoadjuvant concurrent chemoradiotherapy and to correlate the ct findings with pathology. | 2000 | 10667655 |
| apoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspases 3, 6 and 8 and apoptosis regulating proteins bcl-2, mcl-1 and bax. | in this study we investigated apoptosis and the expression of caspases 3, 6 and 8 and bcl-2, mcl-1 and bax in 39 gallbladder carcinomas and 7 epithelial dysplasias. the average apoptotic index was 0.68 +/- 0.91%. the extent of apoptosis was higher in grade ii-iii than grade i tumours or epithelial dysplasias (p = 0.003). also, tumours invading beyond serosa or into other organs (t3-t4) had a higher apoptotic index than other tumours (p = 0.05). caspase 3 expression was found in 37 (95%) and casp ... | 2000 | 10668195 |
| complications associated with the use of indwelling epidural catheters in dogs: 81 cases (1996-1999). | to evaluate complications associated with use of indwelling epidural catheters in dogs in a clinical setting. | 2000 | 10668535 |
| laryngeal long-term morbidity after supraglottic laryngectomy and postoperative radiation therapy. | this study was performed to investigate factors associated with laryngeal morbidity when postoperative radiation therapy (rt) is added to supraglottic laryngectomy. | 2000 | 10668672 |
| bacteriophage t4 gene 59 helicase assembly protein binds replication fork dna. the 1.45 a resolution crystal structure reveals a novel alpha-helical two-domain fold. | the bacteriophage t4 gene 59 helicase assembly protein is required for recombination-dependent dna replication, which is the predominant mode of dna replication in the late stage of t4 infection. t4 gene 59 helicase assembly protein accelerates the loading of the t4 gene 41 helicase during dna synthesis by the t4 replication system in vitro. t4 gene 59 helicase assembly protein binds to both t4 gene 41 helicase and t4 gene 32 single-stranded dna binding protein, and to single and double-stranded ... | 2000 | 10669611 |
| [preoperative radiotherapy of rectal cancer. the lyons experience, 1985-1996. prognostic study apropos of 312 patients]. | preoperative radiotherapy is used increasingly in rectal cancer in europe. this study is a retrospective analysis of a series of 312 patients with rectal adenocarcinoma treated by preoperative radiotherapy. | 1999 | 10670149 |
| assessing the effects of thyroid suppression on benign solitary thyroid nodules. a model for using quantitative research synthesis. | systematic review of the available information with a modified, largely quantitative method of research synthesis disclosed that an initial trial of thyroid hormone suppression therapy leads to clinically significant (> or = 50%) reduction of nodule size or arrest of nodule growth in a subset of patients with benign solitary thyroid nodules. in fact, in addition to objective improvements due to decreasing nodule size, l-t4 suppression therapy may benefit patients by reducing perinodular thyroid ... | 2000 | 10670406 |