Publications

serum fructosamine concentration in cats with overt hyperthyroidism.	to determine the effect of hyperthyroidism on serum fructosamine concentration in cats.	1999	10553441
the influence of different intravascular volume replacement regimens on renal function in the elderly.	elderly patients are at risk of developing renal dysfunction. synthetic colloids are often used perioperatively, but they may have detrimental effects on renal function. in a prospective, randomized study, we assessed the influence of different intravascular volume replacement regimens on renal function in elderly (>65 yr) and younger (< 65 yr) patients without preoperative renal dysfunction who were undergoing major abdominal surgery. either 6% low molecular weight hydroxyethyl starch (hes) sol ...	1999	10553822
tumor angiogenesis predicts recurrence with normal serum carcinoembryonic antigen in advanced rectal carcinoma patients.	many studies have established the usefulness of serum carcinoembryonic antigen (cea) oriented serial monitoring for predicting recurrence and prognosis; however, few studies have so far investigated serum cea-negative recurrence. the aim of this study was to elucidate the nature of cea-negative recurrence regarding tumor angiogenesis. fifty-seven patients with t3/t4 rectal cancer were divided into the two groups according to the serum cea status. angiogenesis was defined as the intratumoral vess ...	1999	10554319
combined resection of the thoracic esophagus and thoracic descending aorta.	we conducted combined resection of the thoracic esophagus and thoracic descending aorta in 2 patients, one with advanced esophageal cancer with aortic invasion and the other aortoesophageal fistula caused by a false aortic aneurysm. combined resection of esophageal tumor and adjacent involved organs was conducted in 14 patients with a3:t4 esophageal cancer but none survived 3 years and resecting tumor-invaded organs did not improve patient survival. one major problem of combined resection of the ...	1999	10554419
can we get aids from mosquito bites?	human immunodeficiency virus, or hiv, is a human retrovirus that infects lymphocytes and other cells bearing the cd4 surface marker. the virus is transmitted primarily by sexual and parental routes. there are two ways blood feeding arthropods can spread disease, mechanically, by simple transfer of virus between hosts by contaminated mouth parts, or, biologically, which would require virus replication in arthropod tissues (especially salivary glands). there are some important factors which have p ...	1999	10554479
[low t3 syndrome in multiple trauma patients--a phenomenon or important pathogenetic factor?].	many nonthyroidal illnesses, such as major trauma, severe burn injury, sepsis or immune deficiency are associated with a reduced t3 concentration without increased serum tsh secretion. the pathopysiologic meaning of this phenomenon was controversely discussed since its investigation 20 years ago. the identification of the type i 5-iodthyronine-deiodinase as a selenoenzyme brought many new aspects into this discussion.	1999	10554534
force generation upon hydrostatic pressure release in tetanized intact frog muscle fibres.	single intact muscle fibres isolated from the tibialis anterior muscle of the frog were exposed to hydrostatic pressures of 1-10 mpa, at 2-4 degrees c and sarcomere length of 2.1-2.2 microm. the pressure was rapidly released (ca. 1 ms) to atmospheric level (0.1 mpa) during the plateau of a tetanic contraction (po) and the resultant tension (= force) transient examined. the pressure release induced tension transient consisted of an initial tension drop coincident with pressure release (ca. 4% po ...	1999	10555066
high prevalence of hypothyroidism in patients with primary pulmonary hypertension.	to characterize the prevalence of hypothyroidism in a population with primary pulmonary hypertension (pph).	1999	10555089
a new classification for malignant tumors involving the anterior skull base.	to propose our clinical classification of malignant ethmoid tumors and to compare it with the last american joint committee on cancer (ajcc)-union internationale contre le cancer (uicc) classification, published in 1997.	1999	10555698
prognostic factors in follicular carcinoma of the thyroid--a multivariate survival analysis.	multivariate studies of the diagnosis, treatment and prognosis of patients with follicular carcinoma of the thyroid gland are relatively scarce. the aim of our multivariate analysis was to study the factors associated with survival of patients with follicular carcinoma in slovenia, in an iodine-deficient region.	1999	10556007
substitution with selenomethionine can enhance the stability of methionine-rich proteins.	the availability of a series of phage t4 lysozymes with up to 14 methionine residues incorporated within the protein has made it possible to systematically compare the effect on protein stability of selenomethionine relative to methionine. wild-type lysozyme contains two fully buried methionine residues plus three more on the surface. the substitution of these methionine residues with selenomethionine slightly stabilizes the protein. as more and more methionine residues are substituted into the ...	1999	10556025
biochemical markers of bone turnover in patients with thyroid dysfunctions and in euthyroid controls: a cross-sectional study.	hyperthyroidism is associated with reduced bone mineral density. conflicting data exist regarding the effects of thyroxine therapy on bone metabolism. the aim of the present study was to assess changes in markers of bone turnover in thyroid dysfunction. a total of 28 patients with overt hyperthyroidism, eight patients with suppressed tsh levels (thyroid hormones within the euthyroid range, no t4 therapy), 25 euthyroid and four hypothyroid patients were included in the present study. hyperthyroid ...	1999	10556662
two new early bacteriophage t4 genes, repea and repeb, that are important for dna replication initiated from origin e.	two new, small, early bacteriophage t4 genes, repea and repeb, located within the origin e (orie) region of t4 dna replication, affect functioning of this origin. an important and unusual property of the orie region is that it is transcribed at early and late periods after infection, but in opposite directions (from complementary dna strands). the early transcripts are mrnas for repea and repeb proteins, and they can serve as primers for leading-strand dna synthesis. the late transcripts, which ...	1999	10559179
lymphocyte subsets and sister-chromatid exchanges in the students exposed to formaldehyde vapor.	the present report evaluates the effects of formaldehyde (fa) exposure on peripheral lymphocytes by using both genetic and immunological parameters. twenty-three non-smoking students in the study had inhalation exposure to 0.508 +/- 0.299 mg/m3 of fa for a period of 8 weeks (3h x 3 times each week) during anatomy classes. as for composition of lymphocyte subsets after fa exposure, significant increase was found in the percentage of cd19 (b cells), while significant decrease was observed in cd3 ( ...	1999	10560533
immunoglobulins of untreated graves' patients with or without thyrotropin receptor antibody (determined by porcine thyrocytes) universally elicit potent thyroid hormone-releasing activity in cultured human thyroid follicles.	thyrotropin receptor antibody (trab), comprising thyrotropin binding inhibitor immunoglobulin (tbii) and thyroid-stimulating antibody (tsab), both of which are conventionally determined using porcine thyrocytes in japan, is not always positive in patients with untreated graves' disease. to elucidate whether immunoglobulin g (igg) obtained from tbii/tsab-positive (+) or negative (-) graves' disease patients are responsible for hyperthyroidism, we investigated the thyroid hormone-releasing activit ...	1999	10560951
anaplastic thyroid cancer with transient thyrotoxicosis: case report and literature review.	a 55-year-old woman with anaplastic thyroid carcinoma presented with hyperthyroidism and neck swelling, hoarseness, and cervical lymphadenopathy. on physical examination, she was found to be clinically hyperthyroid with an enlarged, nontender multinodular goitre. her serum thyroid hormone levels confirmed hyperthyroidism and technetium-99m pertechnetate scan failed to visualize the thyroid gland. open biopsy showed an invasion of the thyroid gland by anaplastic thyroid carcinoma. the thyrotoxic ...	1999	10560959
impact of preoperative bimodality induction including twice-daily radiation on tumor regression and survival in stage iii non-small-cell lung cancer.	the objective of this prospective study was to assess the feasibility, toxicity, and efficacy of an intensive trimodality approach in stage iii non-small-cell lung cancer (nsclc).	1999	10561177
definitive chemoradiotherapy for t4 and/or m1 lymph node squamous cell carcinoma of the esophagus.	to investigate the efficacy and feasibility of concurrent chemoradiotherapy for locally advanced carcinoma of the esophagus.	1999	10561371
thyroid development in relation to the development of endothermy in the red-winged blackbird (agelaius phoeniceus).	we investigated the development of thyroid function during the transition to endothermy in red-winged blackbirds (agelaius phoeniceus). thermoregulatory capabilities of blackbirds improve markedly over their relatively short nestling period (10-12 days), with the most striking improvements occurring between days 6 and 8. we hypothesized that the development of endothermy in these birds is dependent in part on the development of thyroid function. we assessed thyroid development by measuring chang ...	1999	10562450
end results of a prospective trial on elective lateral neck dissection vs type iii modified radical neck dissection in the management of supraglottic and transglottic carcinomas. brazilian head and neck cancer study group.	either modified type iii radical neck dissection (mrnd) or lateral neck dissections (lnds) are considered valid treatments for patients with laryngeal carcinoma with clinically negative neck findings (n0). the object of this prospective study was to compare complications, neck recurrences, and survival results of elective mrnd and lnd on the management of laryngeal cancer patients. patients and methods this prospective randomized study began in 1990, and patient accrual was closed on december 19 ...	1999	10562681
cancer of the base of the tongue: past and future.	squamous cell carcinomas of the base of the tongue often are diagnosed at advanced stages, in a context of undernutrition with a history of smoking and alcoholism. the local treatment of these tumours is based on external irradiation, either alone or combined with brachytherapy, followed by salvage surgery in the case of failure. surgery was rarely performed as first-line treatment in our institution until 1992.	1999	10562689
a randomized trial comparing regimens of four reverse transcriptase inhibitors given together or cyclically in hiv-1 infection--the quattro trial. quattro steering committee.	to assess if cyclical therapy with four reverse transcriptase inhibitors is less toxic and as active, based on virological and immunological markers, as the same four drugs given together over a 64-week period.	1999	10563706
a chronic model for intravital microscopic study of microcirculatory disorders and leukocyte/endothelial cell interaction during normotensive endotoxemia.	sepsis-induced microvascular leukocyte/endothelial cell interaction may result in a deterioration of capillary perfusion that finally leads to septic organ dysfunction. the aim of the present study was to characterize a novel, sublethal, two-hit model of chronic systemic sepsis that allows the repeated analysis of microcirculation by intravital microscopy. in syrian golden hamsters the effect of a single i.v. endotoxin (lps, 2 mg/kg, e. coli) injection (sh-lps group, n = 5 animals) vs. a double ...	1999	10565610
effect of methimazole pretreatment on serum thyroid hormone levels after radioactive treatment in graves' hyperthyroidism.	radioiodine (131i) is the preferred definitive treatment for graves' hyperthyroidism. pretreatment with antithyroid drugs is often used to avoid thyroid hormone discharge after 131i ablation. however, this may represent an unnecessary increase in risk and costs. fifty-one patients with graves' disease were randomly assigned to receive 131i alone (28 patients) or 131i plus pretreatment with methimazole (30 mg/day; 23 patients). methimazole was interrupted 4 days before 131i therapy. serum t4, fre ...	1999	10566642
quantitative reverse transcription-polymerase chain reaction of circulating thyroglobulin messenger ribonucleic acid for monitoring patients with thyroid carcinoma.	patients with thyroid cancer are monitored for disease recurrence by measurement of serum thyroglobulin (tg) and iodine-131 (131i) scanning. to enhance sensitivity and to circumvent antibodies that interfere with tg immunoassays, we have developed rt-pcr assays that detect circulating thyroid messenger rna (mrna) transcripts. we now report results using a sensitive quantitative tg mrna assay (taqman; abi, foster city, ca) in comparison with immunoassay in patients previously treated for thyroid ...	1999	10566646
regulation of uncoupling protein-2 and -3 by growth hormone in skeletal muscle and adipose tissue in growth hormone-deficient adults.	the newly described uncoupling proteins, ucp2 and ucp3, may play a role in regulating energy expenditure (ee) in humans. gh deficiency (ghd) is associated with decreased lean body mass, increased adiposity, and reduced ee, which are reversed by gh treatment. in the present study we investigated whether gh treatment for 4 months influenced the expression of ucps in skeletal muscle and adipose tissue in 22 ghd patients who were investigated before and after gh (n = 11) or placebo (n = 11) treatmen ...	1999	10566652
streptococcus pyogenes isolated in portugal: macrolide resistance phenotypes and correlation with t types. portuguese surveillance group for the study of respiratory pathogens.	from january 1998 to june 1999, 302 clinical isolates of streptococcus pyogenes were collected from 10 microbiology laboratories in portugal. all strains were highly sensitive to penicillin (mic90 = 0.012 mg/liter). the prevalence of erythromycin resistance was 35.8% and of tetracycline resistance 41.4%. the majority (79.6 %) of erythromycin-resistant strains were of the mlsb constitutive resistance (cr) phenotype with high-level resistance to erythromycin (mic90 >256 mg/liter) and to clindamyci ...	1999	10566873
[spontaneous spinal cord herniation: a little-known cause of brown-sequard syndrome. report of two cases and review of the literature].	we report two cases of spinal cord herniation. the first one concerns a 28 year-old female who presented with an eighteen-month past history of spasticity of the right lower limb associated with somesthetic sensorial disturbances of the left side with a t4 level, related to a t3-t4 spinal cord herniation. the second case concerned a 58 year-old female with a past history of a left lower limb pyramidal syndrome associated with somesthetic and proprioceptive sensibilities disturbances of the right ...	1999	10567963
response of the pituitary and thyroid to tropic hormones in sprague-dawley versus fischer 344 male rats.	modulation of endocrine function is frequently a confounding factor in the interpretation of chronic rodent toxicology studies. of particular interest are agents that cause deviation of thyroid hormone homeostasis and result in thyroid cancer for rodents. an endocrine challenge test (ect), commonly used to study endocrine organ health in human and veterinary medicine, quantifies the response of the thyroid to tropic hormones. this study compared the response of fischer (f344) and sprague-dawley ...	1999	10568704
lipids in rat liver submitted to acute and chronic hyperthyroidism.	the effect of acute and chronic hyperthyroidism was studied in serum and liver lipids in rats. wistar adult female rats were separated into three groups. the first group, injected with saline solution was used as control (co), while the second and third were injected daily with tetraiodothyronine (t4) 10 microg/100 g body weight; the second group (ht-i) for one week and the third group (ht-ii) for five weeks. in ht-i, serum t4 level was higher than in ht-ii. triiodothyronine (t3) concentration i ...	1999	10569253
intra-strand biases in bacteriophage t4 genome.	in bacteriophage t4, a major portion of dna replication is initiated at random along the map, although several proven and putative origins have been described for early replication. in order to analyze the contribution of transcription and translation as well as dna replication to intra-strand bias from a = t and g = c, we examined the pattern of the intra-strand biases in the first, second, and third codon positions of the coding regions as well as the intergenic regions of the t4 genome. we fo ...	1999	10570984
evaluation of thyroid function in lithium-naive bipolar patients.	a high prevalence of thyroid hypofunction has been found in bipolar patients. however, the samples used in previous studies included a high percentage of patients in treatment with lithium and carbamazepine. since the use of these drugs may explain the high prevalence of thyroid disturbances found in bipolar patients, we designed the present study to assess thyroid function in a sample of bipolar patients who had not been treated previously with lithium or carbamazepine. patients included in the ...	1999	10572366
limited t4 exonuclease activity and partial fill-in expand insertion site options for pcr subcloning.		1999	10572636
association of prevalent vertebral fractures, bone density, and alendronate treatment with incident vertebral fractures: effect of number and spinal location of fractures. the fracture intervention trial research group.	vertebral fractures are the most common osteoporotic fracture and are associated with significant pain and disability. prior vertebral fracture and low bone mineral density (bmd) are strong predictors of new vertebral fracture. using data from 6082 women, ages 55-80 years, in the fracture intervention trial (a randomized, placebo-controlled trial of the antiresorptive agent, alendronate), we explored the association of the number of prior vertebral fractures with the risk of new fractures and wh ...	1999	10574584
glycyl radical enzymes: a conservative structural basis for radicals.	the first structures of glycyl radical enzymes, the anaerobic ribonucleotide reductase from bacteriophage t4 and pyruvate formate lyase from escherichia coli, have been recently determined. this work provides new insights into the structure and chemistry of glycyl radical sites.	1999	10574800
plasma insulin-like growth factor-i and serum igf-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in african-american and hispanic women.	in vitro studies have shown that insulin-like growth factor (igf) is a mitogen for breast cancer cells. however, the associations of plasma igf-i with tumor histopathology in high-risk groups need further investigation. we hypothesize that plasma igf-i and serum igfbp3 concentrations in breast cancer patients may provide useful information on the progression of their disease, and determine the probability of recurrence and survival. we have carried out a retrospective study on 130 minority breas ...	1999	10575321
positive impact on surgical treatment for asymptomatic patients with esophageal carcinoma.	the prognosis of patients with esophageal carcinoma remains unsatisfactory. the purpose of this study was to clarify the clinicopathologic characteristics of asymptomatic patients.	1999	10576360
predictive value of decreased p27kip1 protein expression for the recurrence-free and long-term survival of prostate cancer patients.	the p27kip1 gene has been identified as inductor of cell cycle arrest at the g1 checkpoint to prevent entry of somatic cells into the s phase of the cell cycle when substantial dna damage has occurred. it has been suggested that decreased expression of the p27kip1 protein may contribute to the development of human malignancies due to loss of critical antiproliferative mechanisms. in the present study, 95 specimens (t1-t4) from 95 randomly selected patients undergoing radical prostatectomy at the ...	1999	10576664
radiotherapy in bladder cancer.	in the present review, we have evaluated the outcome of radiotherapy in patients with bladder cancer. the exact value of radical radiotherapy is difficult to establish because changes in treatment techniques and selection of patients have biased the results. the 5-year survival rates are reported to be 35-71% in t1 tumors, 27-59% in t2 tumors, 10-38% in t3 tumors and 0-16% in t4 tumors. several other factors, like performance status and hemoglobin level, are important for the outcome. morbidity ...	1999	10577680
nutritional assessment in head injured patients through the study of rapid turnover visceral proteins.	nutritional monitoring of rapid turnover visceral protein is important in the recognition of malnutrition in patients admitted to the intensive care unit (icu). we studied prealbumin and retinol-binding protein in patients who received three different kinds of artificial nutrition in order to evaluate the appropriateness of artificial nutrition.	1999	10578025
complete cervical or thoracic spinal cord transections delay gastric emptying and gastrointestinal transit of liquid in awake rats.	to determine the changes on gastric emptying and gastrointestinal transit of liquid throughout the first week after spinal cord transection (sct) in rats.	1999	10578251
hormonal profiles correlated with season, cold, and starvation in rana catesbeiana (bullfrog) tadpoles.	bullfrog (rana catesbeiana) tadpoles are of value to amphibian researchers because of their large size, and year-round availability due to overwintering in many latitudes. concern over a possible difference in hormonal parameters in tadpoles obtained at different times of the year prompted us to investigate thyroid gland secretion in vitro, plasma and ocular melatonin, and plasma corticosteroids in late pre- to early prometamorphic larvae on 12l:12d. winter tadpoles exposed to 22 degrees c for 3 ...	1999	10579655
human immunodeficiency virus infection in vitro activates naturally integrated human papillomavirus type 18 and induces synthesis of the l1 capsid protein.	human papillomavirus (hpv) infections are prevalent in human immunodeficiency virus (hiv)-positive individuals. to highlight the effect of hiv on hpv expression, hpv-18-positive hiv-permissive hela-t4 cells were either infected with hiv-1 or treated with tat or with the cytokines il-1alpha, il-1beta, il-6 and tnf-alpha. the presence of hpv-18 e1 (early) and l1 (late) transcripts was then determined by dot-blot or northern blot hybridization with e1 and l1 or with genomic hpv-18 dna probes, respe ...	1999	10580055
effect of streptozotocin-induced diabetes mellitus on type 1 deiodinase (d1) in inherited d1-deficient mice.	we investigated the effects of streptozotocin (stz)-induced diabetes on thyroid hormone levels, type 1 deiodinase (d1) activity and messenger rna (mrna) levels in inherited d1 deficient c3h mice in a comparative manner with control c57 mice. the apparent maximum velocity (vmax) d1 values in c3h mice were 3% (liver) and 26% (kidney) of those in c57 mice. in c3h mice, similar serum t3, slightly higher t4, and 2.6-fold higher rt3 levels were observed compared with c57 mice. in stz-induced diabetes, ...	1999	10580741
levothyroxine-induced liver dysfunction in a primary hypothyroid patient.	here we report a case of levothyroxine-induced liver dysfunction. t4 (levothyroxine) has been more commonly used for the treatment of hypothyroidism than t3 active hormone (triiodothyronine), because with the former drug a stabler plasma concentration is obtained after oral administration. although there are few reports on levothyroxine-induced liver dysfunction, we treated a primary hypothyroid patient with high serum aminotransferase after administration of levothyroxine. liver dysfunction was ...	1999	10580751
gene amplification as a common cause of inherited thyroxine-binding globulin excess: analysis of one familial and two sporadic cases.	t4-binding globulin (tbg) is the major thyroid hormone transport protein in humans. inherited abnormalities in the level of serum tbg have been classified as partial deficiency, complete deficiency and excess. a single nucleotide deletion or substitution in the tbg gene, located on xq22, has been detected in partial and complete deficiencies. as for inherited tbg excess, the gene amplification has been recognized in two japanese families recently. in this study, an additional three japanese fami ...	1999	10580756
primary hypothyroidism associated with leishmaniasis in a dog.	a case of primary hypothyroidism associated with leishmaniasis is described in a four-year-old, male yorkshire terrier. clinical diagnosis of hypothyroidism was confirmed by a low baseline serum tetraiodothyronine (t4), a reduced response to thyroid-stimulating hormone (tsh) stimulation, an increased serum tsh concentration, and scintigraphic thyroid gland examination. examination of a thyroid biopsy showed many leishmania amastigotes, both inside and outside of macrophages, together with signs ...	1999	10580908
role of exonucleolytic degradation in group i intron homing in phage t4.	homing of the phage t4 td intron is initiated by the intron-encoded endonuclease i-tevi, which cleaves the intronless allele 23 and 25 nucleotides upstream of the intron insertion site (is). the distance between the i-tevi cleavage site (cs) and is implicates endo- and/or exonuclease activities to resect the dna segment between the is and cs. furthermore, 3' tails must presumably be generated for strand invasion by 5'-3' exonuclease activity. three experimental approaches were used to probe for ...	1999	10581261
intron homing with limited exon homology. illegitimate double-strand-break repair in intron acquisition by phage t4.	the td intron of bacteriophage t4 encodes a dna endonuclease that initiates intron homing to cognate intronless alleles by a double-strand-break (dsb) repair process. a genetic assay was developed to analyze the relationship between exon homology and homing efficiency. because models predict exonucleolytic processing of the cleaved recipient leading to homologous strand invasion of the donor allele, the assay was performed in wild-type and exonuclease-deficient (rnh or dexa) phage. efficient hom ...	1999	10581262
giant cervico-thoracic schwannoma with long clinical history. case report.	an unusual case of a giant intraspinal schwannoma in a 45-year-old woman with 14-year history of preoperative symptoms was presented. mri of the spine revealed an intradural, extramedullary tumor extending from the intervertebral space c4/c5 to t4 vertebral body level (2 x 1.2 x 12 cm) and filling almost the entire spinal canal. microscopical examination showed a typical neurinoma pattern with two distinct zones of antoni a and antoni b tissue. some areas exhibited nuclear atypia and hyperchroma ...	1999	10581856
[vascular pedicle flap of the thyroid or submandibular gland in the reconstruction following partial laryngectomy].	the paper presents the merits and drawbacks of vascular pedicled flaps of thyroid and submandibular glands in the reconstructive surgery following partial laryngectomy (combined with the resection of tongue base if necessary), as well as the results of clinical, radiological, radionucleoloid++ and histological investigation carried out in 81 cases with various extend of neoplasm (t1-t4). the average observation period was 8.2 (min. 1, max. 14) years. the discussed flaps were satisfactorily elast ...	1999	10581945
[the level of diagnosis and treatment results in nasopharyngeal cancer patients].	a group of twenty patients with nasopharyngeal cancer treated in lower silesian oncological centre from year 1991 to 1995 have been presented. in seven of them the extent of the primary tumor was small (t1 or t2), but the rest of them (thirteen) had large extent of it (t3 or t4). in seven patients metastases to the cervical lymphonodes were not observed. the histopathology exam showed in eight cases well differentiated carcinoma, in another eight--lymphoepitelioma, in three--undifferentiated car ...	1999	10581947
docetaxel (taxotere) in the neo-adjuvant setting in non-small-cell lung cancer.	there is a potential for neo-adjuvant chemotherapy to provide significant benefit in outcome for patients with locally advanced non-small-cell lung cancer (nsclc). patients with n2/t3 nsclc have a poor prognosis when treated by surgery alone since micrometastases result in relapse in the majority of cases. the same is true of patients with n3/t4 disease treated only with radiotherapy. systemic therapy is therefore required, and cisplatin-based induction chemotherapy prior to surgery or radiother ...	1999	10582143
[amiodarone and thyroid disorders--prospective study and review of the literature].	a well-known adverse effect of amiodarone is the induction of thyroid dysfunction. the numerous studies evaluating the incidence of amiodarone-induced thyroid dysfunction have given very dissimilar results, because of the variability in the criteria of hyper- and hypothyroidism, on the one hand, and in the iodine intake of the studied population on the other hand. the aim of our study was to evaluate the incidence of amiodarone-induced thyroid dysfunction. one hundred and twelve patients without ...	1999	10582476
changes in serum apolipoprotein concentrations after l-thyroxine therapy in infants with congenital hypothyroidism.	to further characterize the impact of thyroid hormones on the serum lipid profile, we studied serum apolipoproteins in infants with congenital hypothyroidism before and after l-thyroxine (l-t4) replacement therapy. serum high-density lipoprotein cholesterol (hdlc) decreased after l-t4 therapy. total cholesterol (tc) and low-density lipoprotein cholesterol (ldlc) levels did not change significantly after therapy. two months after l-t4 replacement therapy, serum apolipoprotein a-i (apo a-i), c-iii ...	1999	10582538
postpartum thyroid dysfunction: clinical assessment and relationship to psychiatric affective morbidity.	postpartum thyroid dysfunction (pptd), diagnosed using biochemical criteria, is usually transient with a wide range of reported prevalence rates. the specific clinical and psychiatric morbidity associated with pptd is still uncertain. the aims of the study were to determine the point prevalence of pptd in australian women at 6 months postpartum and to assess the specific clinical and psychiatric morbidity in these women.	1999	10583309
abnormal circadian rhythm and increased non-pulsatile secretion of thyrotrophin in sheehan's syndrome.	it has previously been shown that patients with postpartum pituitary necrosis (sheehan's syndrome, ss) have paradoxically increased tsh levels and loss of the nocturnal tsh surge. this study sought to determine the circadian and pulsatile characteristics of tsh secretion underlying those abnormalities.	1999	10583310
iopanoic acid-induced decrease of circulating t3 causes a significant increase in gh responsiveness to gh releasing hormone in thyrotoxic patients.	thyroid hormones participate in gh synthesis and secretion, and an impaired gh response to many pharmacological stimuli, including gh releasing hormone (ghrh), has been found in thyrotoxicosis. although the mechanisms involved in this process have not been fully elucidated, there is evidence that thyroid hormones could act at both hypothalamic and pituitary levels. there are no data in the literature about the effect of an acute reduction of circulating t3 levels on gh secretion in hyperthyroidi ...	1999	10583313
[thyrotoxic periodic paralysis. a report of 2 cases].	thyrotoxic hypokalemic periodic paralysis is characterized by recurrent episodes of motor weakness of variable intensity associated with thyroid overactivity. it is usually associated with low plasma potassium levels and is often precipitated by physical activity or ingestion of carbohydrates.	1999	10584263
efflux of t4 from the in situ perfused liver of rainbow trout: effect of t4, dithiothreitol and cysteine in the perfusate.	a cortland saline-perfused rainbow trout (oncorhynchus mykiss) liver model was used to study aspects of t4 efflux from the intact organ system. there was a consistent efflux of t4 in the absence of t4 in the perfusate, and the t4 efflux was increased in the presence of t4 in the perfusate, but the efflux was not t4-dose dependent. the addition of the thiol-containing compound dithiothreitol (dtt, 2 mm) to the perfusate had no significant effect on the flux of t4 from the liver, whereas the addit ...	1999	10584300
recurrent fetal thyrotoxicosis in a woman with graves' disease: case report.	the thyroid stimulating immunoglobulins are generally believed to be the cause of hyperthyroidism in graves' disease. placental transfer of these antibodies from a mother with autoimmune thyroid disease can result in fetal thyroid disorders. we report the case of a 31-year-old woman who had a history of graves' disease. she received thyroxine therapy for post thyroidectomy hypothyroidism. two years after the thyroidectomy, she became pregnant. unfortunately, intrauterine fetal death occurred in ...	1999	10584424
a multidisciplinary surgical approach to superior sulcus tumors with vertebral invasion.	vertebral body invasion by superior sulcus tumor has traditionally been considered a contraindication to surgical resection. attempts at definitive radiation or chemoradiation have not been successful. recent advances in spinal instrumentation have allowed more complete resection of vertebral body tumors. we, therefore, reviewed our recent experience with vertebral resection of superior sulcus tumors.	1999	10585058
in vitro reconstitution of the bacteriophage t4 clamp loader complex (gp44/62).	the clamp loader complex (clc) of bacteriophage t4 is essential for viability and has analogs in both prokaryotes and eukaryotes. the gp44 and gp62 subunits of the t4 clc, in a 4:1 ratio, tightly associate such that the two proteins co-purify. using transformed escherichia coli, we were able to demonstrate for the first time purification of the unique protein gp62 in the absence of gp44. we experimentally determined the isoelectric point for the individual subunits. an in vitro physical interact ...	1999	10585481
the impact of primary tumor volume on local control for oropharyngeal squamous cell carcinoma treated with radiotherapy.	a study was needed to determine the effect of primary tumor volume on local control of oropharyngeal carcinoma treated with radiation therapy, with or without induction chemotherapy.	2000	10585598
survival and functional results of pearson's near-total laryngectomy for larynx and pyriform sinus carcinoma.	current treatment for most t3 and t4 transglottic and pyriform sinus carcinomas is total laryngectomy or total laryngectomy with partial pharyngectomy. voice rehabilitation usually requires the use of a tracheoesophageal puncture (tep). pearson's near-total laryngectomy (ntl) is an option for voice preservation in selected cases with no invasion of the interarythenoid space and limited invasion of the subglottis. the purpose of this study is to report the functional and survival results of 42 co ...	2000	10585600
[clinical phase ii-evaluation of neoadjuvant, cytostatic combination chemotherapy with docetaxel and epidoxorubicin in female breast cancer patients (t1-4, n0-2, m0)].	preoperative (neo-adjuvant) chemotherapy is very effective in downstaging primary tumors and moreover is able to prevent advancing metastatic growth early in the course of the disease.	1999	10586489
determination of protein secondary structure and solvent accessibility using site-directed fluorescence labeling. studies of t4 lysozyme using the fluorescent probe monobromobimane.	we report an investigation of how much protein structural information could be obtained using a site-directed fluorescence labeling (sdfl) strategy. in our experiments, we used 21 consecutive single-cysteine substitution mutants in t4 lysozyme (residues t115-k135), located in a helix-turn-helix motif. the mutants were labeled with the fluorescent probe monobromobimane and subjected to an array of fluorescence measurements. thermal stability measurements show that introduction of the label is sub ...	1999	10587464
translational regulation by modifications of the elongation factor tu.	ef-tu from e. coli, one of the superfamily of gtpase switch proteins, plays a central role in the fast and accurate delivery of aminoacyl-trnas to the translating ribosome. an overview is given about the regulatory effects of methylation, phosphorylation and phage-induced cleavage of ef-tu on its function. during exponential growth, ef-tu becomes monomethylated at lys56 which is converted to me2lys upon entering the stationary phase. lys56 is in the gtpase switch-1 region (residues 49-62), a str ...	1999	10588048
association between lower serum free t4 and greater mood instability and depression in lithium-maintained bipolar patients.	this investigation evaluated the relationship between changes in thyroid indices and mood stability during lithium and carbamazepine prophylaxis for bipolar disorder.	1999	10588404
the ulinastatin-induced effect on neuromuscular block caused by vecuronium.	we examined the effect of ulinastatin, a protease inhibitor purified from human urine, on neuromuscular block caused by vecuronium. sixty adult patients were randomly divided into four groups of 15 patients each: ulinastatin-posttetanic count (u-ptc), ulinastatin-train-of-four (u-tof), control-posttetanic count (c-ptc) or control-train-of-four (c-tof) group. in the u-ptc and u-tof groups, a bolus dose of ulinastatin 5000 u/kg was administered 2 min before the injection of vecuronium 0.1 mg/kg. i ...	1999	10589650
tp53 accumulation predicts improved survival in patients resistant to systemic cisplatin-based chemotherapy for muscle-invasive bladder cancer.	to examine retrospectively the prognostic significance of tp53 immunoreactivity for both tumor response and patient survival in 83 patients with nonmetastatic muscle-invasive bladder cancer treated with a single transurethral resection (tur) of tumor and combined cisplatin-based systemic chemotherapy followed by repeat tur, paraffin-embedded sections of a bladder tumor obtained at tur before chemotherapy (1 t2, 52 t3, and 30 t4) were immunostained for tp53 using monoclonal pab1801 and do-7 antib ...	1999	10589764
dna helicase mutants of bacteriophage t4 that are defective in dna recombination.	we previously isolated a plasmid-borne, recombination-deficient mutant derivative of the bacteriophage t4 dna helicase gene 41. we have now transferred this 41rrh1 mutation into the phage genome in order to characterize its mutational effects further. the mutation impairs a recombination pathway that is distinct from the pathway involving uvsx, which is essential for strand transfer, and it also eliminates most homologous recombination between a plasmid and the t4 genome. although 41rrh1 does no ...	1999	10589841
variations in eeg coherence as an index of the affective content of dreams from rem sleep: relationships with face imagery.	eeg coherence was examined in relation to four measures of socioemotional dream content, including a new measure--the proportional representation of a character's face. twenty-four healthy subjects, recorded for sleep stages and eeg activity, were awakened from rem sleep to report dream mentation and to rate it on these variables. coherence scores were calculated for homologous interhemispheric electrode pairs (fp1-fp2, f3-f4, f7-f8, c3-c4, p3-p4, o1-o2, t3-t4, t5-t6) and for left and right intr ...	1999	10590819
high-dose-rate brachytherapy for primary carcinomas of the oral cavity and oropharynx.	local control for patients treated with primary radiation therapy for tumors of the oral cavity is improved using low-dose-rate brachytherapy. oropharyngeal carcinomas have also been treated with brachytherapy. the few reports in the literature regarding high-dose-rate brachytherapy (hdrbt) for head and neck cancer involve small numbers of patients and often contain a mix of palliative and curative cases. the purpose of this study is to evaluate the feasibility of hdrbt in the largest reported c ...	1999	10591356
neurological complications of spinal tuberculosis in children.	neurological complications of thoracic and lumbar spinal tuberculosis were studied in 32 patients under the age of 16 years. the majority had lesions involving three or more vertebral bodies. paraplegia occurred in 8 patients and was always associated with bladder and bowel dysfunction. lesions located at t4/5 were most commonly accompanied by paraplegia. deterioration of the neurological status was related to the degree of spinal stenosis, whereas the degree of kyphosis was of less importance. ...	1999	10591936
[serotype distribution and antimicrobial susceptibility of group a streptococci (streptococcus pyogenes) isolated in taiwan].	t-protein serotypes and antimicrobial susceptibility of a total of 139 group a streptococci (gas) strains isolated in taiwan area in 1993 and during the outbreak of scarlet fever in 1994 were analyzed. all strains were t-typable, and t12 (42.46%) and t4 (38.85%) were the dominant t types. according to the results of analysis of antimicrobial susceptibility, all gas strains were divided into 9 resistotypes, a (all susceptible), b (resistant to tetracycline), c (resistant to erythromycin and tetra ...	1996	10592797
extending low-dose epidural analgesia for emergency caesarean section. a comparison of three solutions.	we conducted a prospective double-blind randomised trial to compare bupivacaine 0.5%; a 50 : 50 mixture of bupivacaine 0.5%/lignocaine 2% with 1 : 200 000 adrenaline (final concentration); and lignocaine 2% with 1 : 200 000 adrenaline for converting a low-dose labour epidural into a block adequate for emergency caesarean section. ninety patients were studied, 30 in each group. there was no difference between the groups in the time taken for bilateral loss of cold sensation to reach t4. onset tim ...	1999	10594415
comparison of the effects of desflurane and isoflurane anaesthesia on hepatocellular function assessed by alpha glutathione s-transferase.	the purpose of this study was to investigate the influence of isoflurane and desflurane on hepatocellular function. twenty male patients undergoing elective surgery were randomly assigned to receive either isoflurane or desflurane anaesthesia. alpha glutathione s-transferase concentrations and aminotransferase activities were measured at induction of anaesthesia (t0), 15 min (t1), 90 min after induction (t2), end of surgery (t3) and 2 h thereafter (t4). a significant increase in alpha glutathion ...	1999	10594421
serum thyroxine binding capacity-dependent bias in an automated free thyroxine assay.	the magnitude of serum thyroxine (t4) binding capacity (sbc) dependent bias in the axsym free thyroxine (ft4) assay was assessed using two recently described tests. one of the tests uses a direct equilibrium dialysis (ed) ft4 assay as the reference method. the results obtained with the axsym method were compared with those obtained by the ed ft4 method in patient sera having a wide range of sbc. the other test involves comparison of the ft4 results obtained following dilution of sera by an inert ...	1999	10595855
[a superior vena cava syndrome due to a surgical retractor].	a 56-year-old male diagnosed of epidermoid carcinoma of the right lung (t4 n0 m0, stage iiib) is described. he had earlier received chemotherapy and radiotherapy and was scheduled for removal of the right lung. during surgery the need to resect tumor infiltration of the right atrium became evident. during weaning from by-pass sudden deterioration of hemodynamics occurred with poor response to volume and inotropic drugs. superior vena cava syndrome due to traction of the innominate trunk from a s ...	1999	10596345
thyroid hormone modulates insulin-like growth factor-i(igf-i) and igf-binding protein-3, without mediation by growth hormone, in patients with autoimmune thyroid diseases.	the expression and synthesis of insulin-like growth factor-1 (igf-i) and igf-binding protein-3 (igfbp-3) are regulated by various hormones and nutritional conditions. we evaluated the effects of thyroid hormones on serum levels of igf-i and igfbp-3 levels in patients with autoimmune thyroid diseases including 54 patients with graves' disease and 17 patients with hashimoto's thyroiditis, and in 32 healthy age-matched control subjects. patients were subdivided into hyperthyroid, euthyroid and hypo ...	1999	10596968
autoimmune thyroid disorders in juvenile chronic arthritis and systemic lupus erythematosus.	the appearance of autoimmune thyroiditis in the course of other autoimmune diseases, which do not affect specific organs (systemic lupus erythematosus, sjögren syndrome, rheumatoid arthritis and others), is more frequent than is usually believed. nevertheless, it is scarcely studied, especially in children. the purpose of this study was to look for autoimmune lesions of the thyroid gland in children suffering from juvenile chronic arthritis (jca) and systemic lupus erythematosus (sle). twenty se ...	1999	10599323
diagnosis of hidden central hypothyroidism in survivors of childhood cancer.	to determine how often central hypothyroidism remains undetected by routine out-patient tests of thyroid hormone, we studied 208 pediatric cancer survivors referred for evaluation because of signs of subtle hypothyroidism or hypopituitarism. of the 208 (68 females and 140 males), 110 had brain tumors, 14 had other head/neck tumors, 11 had solid tumors remote from head and neck, and 73 had leukemia. patients were evaluated 1-16 yr (mean, 6.1+/-4.1 yr) after tumor diagnosis. the nocturnal tsh surg ...	1999	10599705
levothyroxine suppression of thyroglobulin in patients with differentiated thyroid carcinoma.	for patients with differentiated thyroid carcinoma, the appropriate degree of tsh suppression by levothyroxine (l-t4) is still unknown. to find the target level of tsh suppression, we analyzed the relationship between the degree of tsh suppression determined by third generation assay and thyroglobulin (tg) response during the titration of the dosage of l-t4. ninety-two patients with differentiated thyroid carcinoma (19 males and 73 females; age, 40.5+/-13.5, mean +/- sd) were included. all of th ...	1999	10599717
relationship between hexamerization and ssdna binding affinity in the uvsy recombination protein of bacteriophage t4.	in bacteriophage t4, homologous genetic recombination events are catalyzed by a presynaptic filament containing stoichiometric quantities of the t4 uvsx recombinase bound cooperatively to single-stranded dna (ssdna). the formation of this filament requires the displacement of cooperatively bound gp32 (the t4 ssdna-binding protein) from the ssdna, a thermodynamically unfavorable reaction. this displacement is mediated by the t4 uvsy protein (15.8 kda, 137 amino acids), which interacts with both u ...	1999	10600121
review: electron crystallography: present excitement, a nod to the past, anticipating the future.	from a modest beginning with negatively stained samples of the helical t4 bacteriophage tail, electron crystallography has emerged as a powerful tool in structural biology. high-resolution density maps, interpretable in terms of an atomic structure, can be obtained from specimens prepared as well-ordered, two-dimensional crystals, and the resolution achieved with helical specimens and icosahedral viruses is approaching the same goal. a hybrid approach to determining the molecular structure of co ...	1999	10600552
[iodine therapy for iodine deficiency goiter and autoimmune thyroiditis. a prospective study].	there is epidemiological and clinical evidence that iodine may induce or promote the manifestation of autoimmune thyroiditis. for this reason it is important to know if substitution of alimentary iodine deficiency or iodine treatment of endemic goitre can cause formation of thyroid antibodies. on the other hand the practical importance of this phenomenon should be evaluated.	1999	10603730
relation between endoscopic ultrasound evaluation and survival of patients with inoperable thoracic squamous cell carcinoma of the oesophagus treated by combined radio- and chemotherapy.	purpose of this study was to assess prognostic value of endoscopic ultrasound in patients with inoperable squamous cell carcinoma of oesophagus treated by radio-chemotherapy.	1999	10604099
effect of von willebrand factor and its proteolytic fragments on kinetics of interaction between the light and heavy chains of human factor viii.	it was previously shown that vwf increases the rate of divalent cation-mediated fviii reconstitution from isolated light chain (lch) and heavy chain (hch) subunits. we examined the effect of vwf on kinetic parameters for interaction between lch and hch in the presence of ca2+ and mn2+ ions, the most effective mediators of fviii reconstitution from isolated subunits, and determined the minimal structural portion of vwf able to enhance fviii formation. we found that affinity (kd) for lch/hch bindi ...	1999	10605949
new reporter cell lines to study macrophage-tropic hiv envelope protein-mediated cell-cell fusion.	the infection of human cells by hiv-1 virus can be mimicked by a fusion process between cells expressing the hiv envelope protein (env) and cells expressing both human cd4 (hucd4) and appropriate human chemokine receptors. in this study, a macrophage-tropic (m-tropic) hiv cell-cell fusion assay was established that utilized hucd4, human ccr5 (huccr5), and hiv adagpl60 as fusion components and a gal4/vp16-activated luciferase as a reporter system. by combining cho cells expressing hucd4 and huccr ...	1999	10606089
thyrotoxicosis, unstable angina and normal coronary angiogram.	it is well known that thyrotoxicosis may elicit acute myocardial ischemia even in patients with angiographically normal coronary vessels. the involved mechanisms are not clearly defined although some hypothesis have been suggested. we report a case of a 54-year-old woman affected by graves' disease with thyrotoxicosis which was referred to our institute because of unstable angina. during hospitalization a two dimensional echocardiogram, performed during chest discomfort, showed left ventricular ...	1999	10609135
iodine and brain development.	the development of the brain is critically dependent on an adequate supply of iodine. iodine is an integral part of thyroid hormone, which acts on brain development by regulating the expression of target genes. the active thyroid hormone, t3, is generated in part in the thyroid gland, but about 80% of t3 in brain is formed locally from t4 deiodination mainly by the action of a specific iodothyronine deiodinase. this enzyme is highly expressed in astrocytes, which take up t4 from the blood and de ...	1999	10609893
integration-proficient plasmids for pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains.	an improved method for integration of exogenous dna fragments at a defined site within the genome of pseudomonas aeruginosa was developed. the method relies on two integration-proficient vectors, mini-ctx1 and mini-ctx2. these two vectors contain (1) a tetracycline (tet) selectable marker, (2) an orit for conjugation-mediated plasmid transfer, (3) the pmb1-derived origin of replication, (4) a modified φctx integrase (int) gene, (5) a versatile multiple cloning site (mcs) flanked by t4 transc ...	2000	10610820
glucuronidation of thyroxine in primary monolayer cultures of rat hepatocytes: in vitro induction of udp-glucuronosyltranferases by methylcholanthrene, clofibrate, and dexamethasone alone and in combination.	induction of udp-glucuronosyltransferases (ugts) toward thyroxine (t4) and p-nitrophenol (pnp) by 3-methylcholanthrene (mc), dexamethasone (dex), clofibrate (cl), and mc combined with dex or cl was studied in rat hepatocyte culture. we have developed a sensitive method for the measurement of glucuronide conjugates of the two substrates based on hplc analysis of culture medium. mc, cl, or dex increased the activity of t4 ugt. combination of mc and cl showed additive effect, enzyme activity was en ...	2000	10611137
an antitumor drug-induced topoisomerase cleavage complex blocks a bacteriophage t4 replication fork in vivo.	many antitumor and antibacterial drugs inhibit dna topoisomerases by trapping covalent enzyme-dna cleavage complexes. formation of cleavage complexes is important for cytotoxicity, but evidence suggests that cleavage complexes themselves are not sufficient to cause cell death. rather, active cellular processes such as transcription and/or replication are probably necessary to transform cleavage complexes into cytotoxic lesions. using defined plasmid substrates and two-dimensional agarose gel ana ...	2000	10611238
structure and folding of bacteriophage t4 gene product 9 triggering infection. i. production and properties of recombinant protein.	gene product 9 (gp9, 288 amino acid residues per monomer, molecular weight 30.7 kd) of bacteriophage t4 triggers the baseplate reorganization and the sheath contraction after interaction of the long tail fibers with the receptors of the bacterial cell. in this work we have produced the recombinant protein and determined that gp9 is a stable homotrimer and active in in vitro complementation assay completing the defective phage particles which lack gp9. according to cd-spectroscopy data, the gp9 p ...	1999	10611531
dose- intensified, preoperative and adjuvant chemotherapy in patients with t3- and t4- breast cancer: toxicity, clinical and pathological remission.	the aim of the study was to investigate a dose-intensified, preoperative chemotherapy with 3 cycles (cy) of epirubicin 60 mg/m2, ifosfamide 5 g/m2 with mesna 5 g/m2, biweekly with g-csf 5 micrograms/kg (filgrastim), in terms of toxicity, clinical and pathological remission rates and changes of immunohistochemical characteristics (er, pr, c-erbb2, p53) during chemotherapy of inoperable patients (pt) with poor prognosis (locally advanced (labc, 9 pt), inflammatory breast cancer (ibc, 12 pt) and m0 ...	1999	10612219
long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism.	the aim of the study was to evaluate serum thyroid hormone balance in children receiving long-term therapy with carbamazepine (cbz), valproate (vpa), and phenobarbital (pb).	1999	10612341
hyperthyroidism decreases thyrotropin-releasing hormone gene expression in the caudal raphe nuclei and the parapyramidal regions in rats.	altered thyroid statuses are associated with autonomic disorders. medullary thyrotropin-releasing hormone (trh) and substance p (sp) regulate autonomic nervous activity. the influences of thyroid statuses on trh and sp gene expressions in the caudal raphe nuclei and the parapyramidal regions were studied using quantitative in situ hybridization histochemistry. in male rats thyroidectomized (tx) for 30 days, the serum t4 levels decreased by 64% and the medullary pro-trh mrna signals (silver grain ...	1999	10612637
survival and postoperative complications after extended surgery for non-small-cell lung cancer. a retrospective study.	we evaluated survival after extended surgery in patients with non-small-cell lung cancer and the effects of induction therapy on results and complications.	1999	10614094