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prostaglandin e2 derivative, enprostil, reduces hepatic triacylglycerol content in japanese quail.this study investigated the effect of prostaglandin e2 derivative, enprostil, on the hepatic lipid metabolism of japanese quail. in experiment 1, the birds received 0.1, 1, 10 or 100 micrograms enprostil/kg body weight intraperitoneally, and they were killed after 10, 30, 60 and 120 min. after 60 min, hepatic triacylglycerol content was reduced most effectively by 10 micrograms enprostil/kg body weight. in experiment 2, effect of enprostil (10 micrograms/kg body weight) on liver enzyme activitie ...19968799460
age-related changes in the ovalbumin gene of the japanese quail.northern hybridization studies showed that the level of ovalbumin mrna decreases in the oviduct of the japanese quail after adulthood. in order to find out if this is due to changes in the conformation of the chromatin containing the promoter region of the gene, nuclei of the oviduct of young, adult and old birds were digested by dnasei and micrococcal nuclease (mnase). southern hybridization with the labelled promoter showed that this region is less sensitive to the two enzymes in the old birds ...19968806640
ultrastructural modifications in cultured fetal quail hepatocytes exposed to pesticides and pcbs.there is increasing interest in cultured hepatocytes as a tool for solving toxicological and pharmacological problems while reducing laboratory animal experimentation. in the present study, fetal hepatocytes from the japanese quail (coturnix coturnix japonica) were used as an in vitro alternative model for evaluating the effects of pcbs and various pesticide-type chemicals on cell ultrastructure. major alterations were demonstrated. the most striking effects of toxicants were an increase in the ...19968812180
plasma thyroxine concentrations in farmed ostriches in relation to age, body weight, and growth hormone.thyroid hormones are of interest in ostriches because, in common with other ratites, ostriches are believed to have evolved through neoteny, a process which, in amphibia, is related to thyroid function. farmed ostriches show marked differences in growth rates, a problem which also could be related to abnormal thyroid function. in adult farmed ostriches (more than 3 years old), mean plasma thyroxine concentration was 1.8 nmol middle dot liter-1 (range 0.2 to 6.5 nmol middle dot liter-1). this is ...19968812401
testosterone effects on vasotocinergic innervation of sexually dimorphic medial preoptic nucleus and lateral septum during aging in male quail.vasotocin fibers are known to innervate regions important in the regulation of sexual behavior and neuroendocrine systems in quail. in this experiment, vasotocinergic innervation of the lateral septum and of the sexually dimorphic medial preoptic nucleus was studied during reproductive aging relative to sexual behavior or following testosterone (t). there were 4 groups of male japanese quail (coturnix japonica) studied: adult reproductive (6 month, n = 4), photoregressed adult (n = 5), old senes ...19968814893
vitamin c supplementation and fear-reduction in japanese quail: short-term cumulative effects.1. fear-related behaviour was measured in individually-housed japanese quail which had received either untreated drinking water (udw) or a vitamin c solution (ascorbyl-2-polyphosphate, app, 1 g l-ascorbic acid/1 for 1 or 4 d. behavioural tests were carried out at 24 or 27 d of age. water consumption was measured daily and plasma ascorbic acid (aa) content was assayed after differential treatment for 1 or 4 d. 2. the quail in the app treatment groups drank significantly more than did those receiv ...19968833525
cholecystokinin a receptor antagonist inhibits feed memory in japanese quail.cholecystokinin (cck) modulates learning and memory processes in mammals. the main objective of this work was to study the effect of two cholecystokinin receptor antagonists (ccka antagonist devazepide and cckb antagonist pd135158) on feed memory processes in japanese quail. memorization of colored food was measured by comparing the feeding behavior of 6- to 8-day-old quails during two successive sessions of 10 min after a 30-min fast in the test box, intersession interval: 24 h. the ccka antago ...19968840921
coexistence of nadph-diaphorase and tyrosine hydroxylase in the mesencephalic catecholaminergic system of the japanese quail.previous studies have shown the presence of a large number of tyrosine hydroxylase immunoreactive neurons and nicotinamide adenine dinucleotide phosphate (nadph)-diaphorase positive elements within the mesencephalic and pontine regions of the japanese quail. in the present study histochemical and immunohistochemical procedures reveal that cells expressing at least one of these two neurochemical markers coexist throughout a large part of the substantia nigra and of the area ventralis of tsai. als ...19968841887
body weights, carcase characteristics, organ weights, abdominal fat, and lipid content of liver and carcase in two lines of japanese quail (coturnix coturnix japonica), unselected and selected for four week body weight.1. the present study was conducted on quails to evaluate the effects of line and sex on body weight, carcase characteristics and organ weights and also to evaluate the effect of line on sex organs, and on carcase and liver lipid content of male quails. 2. chicks of both sexes were weighed weekly until 6 weeks when they were slaughtered. carcase yield, parts yield and measurement, weight of liver, heart, gizzard, abdominal fat and sex organs were obtained. carcase and liver lipid content of male ...19968842465
changes in retinal dopaminergic cells and dopamine rhythmic metabolism during the development of a glaucoma-like disorder in quails.to examine the possible correlation between a dysfunction of the daily rhythm of retinal dopamine (da) and the development of a glaucoma-like disorder in an animal model, the al mutant quail (coturnix coturnix japonica).19968843918
production and purification of japanese quail ovalbumin as fusion protein with glutathione s-transferase in escherichia coli.a plasmid encoding a fusion protein interlinked by thrombin recognition sequence between glutathione s-transferase and japanese quail ovalbumin (without 40 amino acid residues from the 5'-end of the orf) has been constructed, employing the expression system pgex-2t. the deglycosylated fusion protein (64 kda) was purified by affinity chromatography on glutathione agarose beads, analyzed by sds-polyacrylamide gel electrophoresis, immunochemically detected with antiserum raised against japanese qua ...19958851561
imitative learning in male japanese quail (coturnix japonica) using the two-action method.the study of imitative learning in animals has suffered from the presence of a number of confounding motivational and attentional factors (e.g., social facilitation and stimulus enhancement). the two-action method avoids these problems by exposing observers to demonstrators performing a response (e.g., operating a treadle) using 1 of 2 distinctive topographies (e.g., by pecking or by stepping). japanese quail (coturnix japonica) observers exposed to conspecific demonstrators showed a high correl ...19968858851
molecular cloning of quek 1 and 2, two quail vascular endothelial growth factor (vegf) receptor-like molecules.we have previously reported the cloning of two partial cdnas corresponding to two quail (coturnix coturnix japonica) receptor tyrosine kinases (rtks), named quek 1 and quek 2, and their expression in endothelial cells of the early avian embryo. we here report the cloning of the full-size cdnas for both molecules. sequence comparison shows that quek 1 and 2 share an overall amino acid (aa) identity of 49%. they both comprise seven extracellular immunoglobulin-like (ig-like) domains, a single tran ...19968863722
interactions of trans-acting factor(s) with the estradiol response element and nuclear factor 1 of the vitellogenin ii gene of japanese quail.this study was directed at achieving an understanding of the mechanisms by which steroid hormones control the synthesis of vitellogenin (vtg) protein in the liver of the japanese quail. northern hybridization shows that administration of estradiol alone or with progesterone stimulates the synthesis of vtg mrna. gel mobility shift assay of dna fragments containing the ere and nf 1 shows that estradiol alone or with progesterone increases the levels of nuclear proteins that bind to these cis-actin ...19968866005
pathological study of japanese quail embryo with acid alpha-glucosidase deficiency during early development.a pathological study was performed on the tissues of 11 japanese quail embryos with type ii glycogen storage disease (gsd ii) between incubation day (id) 3 and id 15. accumulation of glycogen in vacuoles derived from lysosomes was first seen in cardiac muscle at id 3, in liver at id 5, in wing muscle at id 7, and in pectoral muscle at id 10. the number and size of the glycogen vacuoles gradually increased during development, especially in cardiac muscle. cytoplasmic glycogen particles, showing t ...19968870826
effects of methyl parathion on reproduction in the japanese quail. 19968875837
glutathione s-transferases in the japanese quail: tissue distribution and purification of the liver isozymes.cytosolic glutathione s-transferase (gst) activities toward 1-chloro-2,4-dinitro-benzene (cdnb), 1,2-dichloro-4-nitrobenzene (dcnb), ethacrynic acid (ea), 1,2-epoxy-3-(p-nitrophenoxyl)propane (epnp), trans-4-phenyl-3-buten-2-one(t-pbo), delta 5-androstene-3,17-dione (asd) and trans-stilbene oxide (t-so); cytosolic glutathione peroxidase activity toward cumene hydroperoxide (cuooh); and microsomal gst activity toward cdnb were examined in liver, kidney, brain, and lung of adult male and female ja ...19968884469
distribution of aromatase-immunoreactive cells in the forebrain of zebra finches (taeniopygia guttata): implications for the neural action of steroids and nuclear definition in the avian hypothalamus.cells immunoreactive for the enzyme aromatase were localized in the forebrain of male zebra finches with the use of an immunocytochemistry procedure. two polyclonal antibodies, one directed against human placental aromatase and the other directed against quail recombinant aromatase, revealed a heterogeneous distribution of the enzyme in the telencephalon, diencephalon, and mesencephalon. staining was enhanced in some birds by the administration of the nonsteroidal aromatase inhibitor, r76713 rac ...19968885196
serum concentrations of thyroid hormones during egg laying in two types of japanese quail (coturnix coturnix japonica).in the present investigation a lighter white egg-type (l) and a heavier wild meat-type (m) of female japanese quails were compared with respect to egg production, body growth, abdominal fat pad, serum thyroxine (t4) and triiodothyronine (t3) concentrations, trh sensitivity and t4 5'-monodeiodinase activity in liver homogenates. during the investigation period l type layed considerably more eggs and m type was heavier in body weight. abdominal fat pad in l type quails was significantly higher tha ...19948891179
short-term selection for four-week body weight in japanese quail.japanese quail have been utilized as a research animal to establish genetic relationships that may be present in other poultry species. in this presentation, short-term selection experiments were reviewed. selection intensity appeared to be the most effective in improving bw when selection experiments were compared on a response per generation basis; however, when generation interval was reduced, the response per year was superior despite lower selection intensities for lines selected the same n ...19968893293
long-term selection for body weight in japanese quail under different environments.long-term selection was conducted for high 4-wk bw in japanese quail under different selection environments to investigate selection limits and to determine whether genetic parameters for growth are similar to those in chickens. quail lines were selected under an adequate 28% cp diet (p line) and under a low 20% cp diet (t line). mean realized heritabilities ranged from 0.32 (t line) to 0.49 (p line) during the first 10 generations. although genetic variation remained following 97 generations of ...19968893294
absence of coexistence between nadph-diaphorase and antidiuretic hormone in the hypothalamus of two galliforms: japanese quail (coturnix japonica) and chicken (gallus domesticus).based on previous studies demonstrating coexistence of nadph-diaphorase (nd) and vasopressin (vp) in the rat hypothalamus. nd histochemistry and vasotocin (vt) immunocytochemistry have been combined in order to study the distribution of both markers in the hypothalamus of the japanese quail (coturnix japonica) and chicken (gallus domesticus). no coexistence was found, however, close anatomical relationships between nd-positive and vt-immunoreactive elements were observed in specific preoptic and ...19968897481
disposition of metronidazole in hens (gallus gallus) and quails (coturnix coturnix japonica): pharmacokinetics and whole-body autoradiography.hens were given single intravenous or oral doses (30 mg/kg body weight) of metronidazole and the plasma concentrations of the drug were determined by high-performance liquid chromatography (hplc) at intervals from 10 min to 24 h after drug administration. pharmacokinetic variables were calculated by the lagrange algorithm technique. the elimination half-life (t1/2 beta) after the intravenous injection was 4.2 +/- 0.5 h, the volume of distribution (vd(ss) 1.1 +/- 0.2 l/kg and the total body clear ...19968905568
effect of dietary cholesterol on the activities of key enzymes of cholesterol metabolism in hyperlipidemia- and atherosclerosis-prone japanese quail.the hyperlipidemia- and atherosclerosis-prone (hap) japanese quail is a strain developed for the study of atherosclerosis by genetic selection from the commercially available (ca) japanese quail. to delineate the characteristics of cholesterol metabolism in this strain, concentrations of serum lipids as well as hepatic enzyme activities were compared between hap and ca quail. the hepatic enzymes studied are involved in the key step reaction in cholesterol metabolism: hmg-coa reductase, acat, and ...19968906630
effect of retinyl acetate, ascorbic acid and tocopherol supplementation of the feed on egg vitamin a content in japanese quail.the ration fed to laying japanese quails was supplemented either with retinyl acetate (ra) (50 x 10(3) iu/kg, group a), ascorbic acid (500 mg/kg, group c), or with both substances in combination with each other (group ac) and with tocopheryl acetate (37.8 iu/kg; groups ae and ace). on days 1, 8, 14, 20 and 28, some quantitative parameters of eggs (mass of egg-shell, albumen and egg yolk, retinoid content of egg yolk) were measured. the egg production parameters were not significantly affected by ...19968908745
inherited muscular disorder in mutant japanese quail (coturnix coturnix japonica): an immunohistochemical study.cryostat sections of myofibres from the musculus pectoralis thoracicus of a newly established mutant strain (lwc) of japanese quail with a myotonic dystrophy-like myopathy were labelled with antibody against myosin heavy chain (mhc) isoforms and neural cell adhesion molecule (n-cam). the characteristic lesions found in sections of muscle of lwc quail stained with haematoxylin and eosin were type 2b fibre atrophy, sarcoplasmic masses, and ring fibres. immunohistochemical examination failed to dis ...19968910742
gluconeogenesis and glucose replacement rate during long-term fasting of japanese quails.gluconeogenic activity and kinetic parameters of glucose metabolism were estimated during the different phases of prolonged food deprivation in quails. gluconeogenic activity, estimated from the rate of increase of incorporation of h14co-3 into circulating glucose, was significantly higher in fasted quails than in fed birds, whatever the period of food deprivation. however, gluconeogenic activity during phase ii, although higher than in the fed state, was significantly lower than in quails faste ...19968916549
host range, survival in dead hosts, cryopreservation, periodicity and morphology of plasmodium durae herman in experimental infections.in experimental infections, fowl, duck, guineafowl and canary were refractory to plasmodium durae, which in japanese quail produced low and transient infections, but a high and long-lasting parasitaemia in a lady amherst pheasant. heart, blood and brain of dead hosts injected into turkeys, allowed the recovery and further passaging of the live parasite. this technique could be useful for the recovery of malaria parasites from suspect postmortem material. intravenous infection produced parasitaem ...19968917860
fibromuscular dysplasia in intramuscular arteries of japanese quail (coturnix coturnix japonica).fibromuscular dysplasia (fmd) was found in the intramuscular arteries of both commercial (normal) and mutant (lwc) strains of japanese quail. the mutant strain lwc is afflicted with an inherited muscular dystrophy exhibiting myotonia. the arterial lesions were classified as medial fibroplasia or medial hyperplasia, both being subtypes of medial fmd. some lesions showed extensive proliferation of medial smooth muscle into the vascular lumen, resulting in partial occlusion of the affected blood ve ...19968920213
regeneration of myelinated fiber after crush injury is retarded in sciatic nerves of mutant japanese quails deficient in neurofilaments.regeneration of myelinated fibers in the sciatic nerve 2 weeks after crush injury was studied morphometrically in mutant japanese quails deficient in neurofilaments and in normal quails (controls). there were fewer regenerated myelinated fibers per nerve at 10 mm (r1) and 20 mm (r2) distal to the crush site in mutants than in controls (p < 0.05). both median and maximum diameters were smaller (p < 0.01) in mutants than in controls. on electron microscopy, transverse axonal area and axonal circum ...19968922058
distribution of avt gene expressing neurons in the prosencephalon of japanese quail and chicken.detailed anatomical studies about the distribution of arginine-vasotocin (avt) gene expressing neurons in the avian brain are so far non-existent. most of the investigations are limited to discrete brain nuclei in the chicken and concern particular experimental conditions. since no data on avt gene expression are up to now available in japanese quail, we report here the distribution of avt mrna containing neurons within the prosencephalon of this bird and a comparison with the same system of the ...19968929339
effect of niacin deficiency on the thermal stability of nad- and nadp-dependent dehydrogenases in liver and pectoral muscle of japanese quail.the objective of this study was to determine whether the concentration of pyridine nucleotides in muscle and liver tissue of quail affected the heat stability of aldolase and selected enzymes involved in the oxidation-reduction of these cofactors. the thermal stability of malic enzyme, glyceraldehyde-3-phosphate dehydrogenase, lactic dehydrogenase, and aldolase in liver, and in pectoral muscle of quail was studied at incubation temperatures ranging from 27 to 60 degrees c. the concentrations of ...19968930142
paired pineals in the developing quail (coturnix coturnix japonica) embryos.paired pineals were observed as an anomaly in embryonic quail brains between 7 and 9 days of incubation. the size of each pineal was almost the same as that of the normal pineal and it was located slightly lateral of the midline. histological examination of these paired pineals revealed that both had similar cytological features in comparison with the normal pineal of the same developmental stage. no abnormal features were detected in brains and eyes of the embryos with paired pineals. since the ...19968940911
tectal neurons that participate in centrifugal control of the quail retina: a morphological study by means of retrograde labeling with biocytin.an avian retinopetal nucleus, the isthmo-optic nucleus (ion), is known to receive predominant inputs from the ipsilateral optic tectum. we injected biocytin into the ion in the japanese quail, and retrogradely labeled tectal neurons projecting to the isthmo-optic (io) neurons, or the tecto-io neurons, with an extraordinary golgi-like quality. somata of the tecto-io neurons were located in layer 9 of the tectum. the tecto-io neurons did not have apical dendrites extending into superficial retino- ...20158961541
dietary cholesterol effects on plasma and yolk cholesterol fractions in selected lines of japanese quail.japanese quail from lines that had been divergently selected for high (hl) or low (ll) plasma total cholesterol and their unselected control line (cl) were fed an all vegetable diet to which 0 or 0.5% crystalline cholesterol were added. relationships between plasma and yolk cholesterol fractions were examined at 10, 14, and 18 wk of age, which followed 2, 6, and 10 wk consumption of the cholesterol-enriched diet, respectively. unesterified cholesterol (uc) and cholesteryl esters (ce) in plasma a ...19968966183
[the effect of hypodynamia on striated muscles in japanese quail].the effect of hypodynamia during 9, 30, 60 and 90 days on the striated muscle m. gastrocnemius in japanese quails was studied. we have found different developed dystrophic changes of mitochondria, myofibrils and sarcotubular system. changes of the studied tissue caused by hypodynamia in the first two groups (9 and 30 days hypodynamy) are the reaction to stress and developing situation. gradually japanese quails have come up to the influence of the hypodynamia (60 days hypodynamia). in the last e ...19968966966
retinal melatonin is not involved in corneal mitotic rhythms in the japanese quail: effects of formoguanamine hydrochloride and eye-lid suture.relation between retinal melatonin and corneal mitotic rhythms in the japanese quail was investigated in experiments manipulating the ocular physiology by treatments with formoguanamine hydrochloride (fg) and eye-lid suture. in experiment 1, we investigated the effects of fg, which is known to induce photoreceptor degeneration, on retinal melatonin and corneal mitotic rhythms. fg-treatment completely abolished the retinal melatonin rhythms in both ld 12:12 and constant darkness (dd), but the cor ...19968981259
effects of the glycoprotein sugar chains on the amino-carbonyl reaction of chicken and japanese quail ovomucoids with glucose.the amino-carbonyl reactions of two glycoproteins, chicken ovomucoid and quail ovomucoid, which have similar amino acid sequences but different sugar chains, were compared. the free guanidino groups, but not amino groups, of chicken ovomucoid decreased more rapidly than those of quail ovomucoid during reaction with glucose. protein polymerization and formation or brownish or fluorescent compounds also occurred more quickly in the chicken ovomucoid. these results suggested that the sugar chain mo ...19968987600
expression of fos-like immunoreactivity in the brain of quail chick emitting the isolation-induced distress calls.the social isolation intensively induces distress call in neonatal chicks of japanese quail. the brain regions activated during the isolation were mapped using immunocytochemical detection of c-fos (the product of immediate early gene c-fos). fos-like immunoreactivity was observed in a variety of brain regions in isolated chicks that had emitted distress calls. the density of fos-positive cells in dorso-medial mesencephalic areas (including the intercollicular nucleus and the central gray) was m ...19968994225
water transport in collecting ducts of japanese quail.previously, we reported that the countercurrent urine concentration mechanism in birds appears to operate by recycling of a single solute (nacl), in which the thick ascending limb of looped nephrons provides an energy source. to determine the importance of the medullary collecting duct (mcd) in the countercurrent multiplier system, we examined in isolated and perfused mcds from japanese quail, coturnix coturnix, the osmotic and/or diffusional water permeability and whether arginine vasotocin (av ...19968997350
dietary cholesterol metabolism in japanese quail lines selected for plasma cholesterol levels.dietary cholesterol metabolism was studied, using a single dose of emulsion, per os (test meal), in lines of japanese quail that were divergently selected for high (hl) and low (ll) plasma total cholesterol. the meal contained [3h] cholesterol, [14c] beta-sitosterol, unlabeled cholesterol, triolein, and bile salt. recovery of the nonabsorbable beta-sitosterol in the excreta permitted determination of the percentage of cholesterol absorbed. the amounts of [3h] in the plasma, egg yolks, and the ex ...19979012362
demonstration, localization, and development of galanin receptors in the quail oviduct.we recently isolated an oviposition-inducing peptide that was identified as avian galanin from the oviducts of the japanese quail. avian galanin was localized in neural fibers distributed in muscle layers in the uterine and vaginal oviduct regions, and potentiated spontaneous contractions of the uterus and vagina. to elucidate whether an oviposition-inducing effect of avian galanin is due to the direct action on the oviduct, therefore, a specific binding site for avian galanin was determined in ...19979018843
epidemiology of inclusion body hepatitis in poultry in northern india from 1990 to 1994.the epidemiology of inclusion body hepatitis (ibh) was studied in poultry in northern india, from april 1990 to march 1994, to evaluate the various factors responsible for causing and determining the severity of the disease. broiler chicks and japanese quail (coturnix coturnix japonica) were the species examined. the factor observed to be most commonly associated with ibh was the presence of aflatoxins in the feed at higher than permissible levels, i.e. 20 parts per billion. avian adenovirus-1 w ...19969025150
dilute down lethal: a new lethal mutation in japanese quail."dilute down lethal (ddl)" is a new mutation of japanese quail (coturnix japonica). neonatal plumage of the ddl mutant is the same as the wild type in pattern, but its coloration is slightly lighter than that of the wild type. in addition to the down color abnormality, some ddl chicks have bent digits. all ddl chicks die within three days of age. genetic analysis revealed that the ddl mutation is controlled by an autosomal recessive gene. the proposed gene symbol is ddl.19979027479
maturation and ovulation of japanese quail oocytes under in vitro conditions.1. an in vitro system for ovulation and maturation of japanese quail oocytes is described. 2. ovarian follicles removed from the ovary at 2, 4 or 6 h before the estimated time of ovulation may ovulate under in vitro conditions. 3. the presence of progesterone in the medium had a stimulatory effect on the process of maturation, as has been shown for xenopus oocytes.19969034583
eye and gonad: role in the dual-oscillator circadian system of female japanese quail.experiments were conducted to determine the anatomic and physiological basis of the dual-oscillator circadian system of female japanese quail. after blocking of ocular light perception by eye-patching, the circadian body temperature rhythm dissociates into two circadian components in continuous lighting (ll). one component free runs with a period significantly shorter than 24 h [mean period (tau) = 22.7 h] and is driven by an ocular pacemaker, whereas the other component free runs with a period ...19979039006
do sex differences in the brain explain sex differences in the hormonal induction of reproductive behavior? what 25 years of research on the japanese quail tells us.early workers interested in the mechanisms mediating sex differences in morphology and behavior assumed that differences in behavior that are commonly observed between males and females result from the sex specificity of androgens and estrogens. androgens were thought to facilitate male-typical traits, and estrogens were thought to facilitate female-typical traits. by the mid-20th century, however, it was apparent that administering androgens to females or estrogens to males was not always effec ...19969047287
intracerebral sex differences in the vasotocin system in birds: possible implication in behavioral and autonomic functions.the brain vasotocinergic system demonstrates clear sexual dimorphism in birds investigated so far. this paper examines the evidence obtained in studies on gallinaceous (domestic fowl, japanese quail) and passerine (canary, junco, zebra finch) birds. vasotocin (vt)-immunoreactive parvocellular neurons are present in the nucleus of stria terminalis of males, but they are less abundant or absent in the corresponding structure of females. a similar difference has been observed in the dorsal paravent ...19969047289
changes in multiple brain regions underlie species differences in a complex, congenital behavior.the evolutionary brain modifications that produce any complex, congenital behavioral difference between two species have never been identified. evolutionary processes may (i) alter a single, "higher" brain area that generates and/or coordinates the diverse motor components of a complex act; (ii) separately change independent, "lower" brain areas that modulate the fine motor control of the individual components; or (iii) modify both types of areas. this study explores the brain localization of a ...19979050894
aromatase immunoreactivity in axon terminals of the vertebrate brain. an immunocytochemical study on quail, rat, monkey and human tissues.intraneuronal production of estradiol from testosterone has been shown to play a pivotal role in gender-specific brain development of most vertebrates, and to participate in numerous functions of the adult central nervous system. previous biochemical and morphological approaches demonstrated that estrogen synthetase (aromatase) is present in specific limbic and hypothalamic structures. on the other hand, less attention has been paid to revealing its subcellular distribution. the possibility of a ...19969053779
changes in serum triiodothyronine, thyroxine, estradiol-17 beta, progesterone levels and egg production in hypocholesterolemia induced japanese quails coturnix coturnix japanica.mature healthy female japanese quails injected (i.p.) with gemfibrozil at two dose levels for 1,2,3 and 4 weeks induced hypocholesterolemia as observed by the serum cholesterol concentration which was more severe with the higher dose. liver and ovarian cholesterol contents decreased in 3rd and 4th week of the treatment. significant (p > 0.05) increase in serum triiodothyronine (t3) and thyroxine (t4) level were observed between 3rd and 4th week while serum estradiol-17 beta and progesterone leve ...19969055651
cloning and origin of the two forms of chicken vitamin d receptor.the cdna for the chicken vitamin d receptor (vdr) has been cloned in full length by screening cdna libraries from chicken intestine and chicken kidney. the chicken kidney cdna library constructed by both oligo(dt) and random primer methods yielded several full-length clones. these contained a 66-bp additional coding sequence at the 5' end in comparison to the cdnas of human, rat, and mouse vdr. the japanese quail vdr cdna was also cloned in full length. we found that the 5' coding sequence repor ...19979056239
inhibitory role of opioid peptides in the regulation of aggressive and sexual behaviors in male japanese quails.we have recently isolated three opioid peptides, i.e., met- and leu-enkephalins and met-enkephalin-arg6-phe7, from the avian brain. furthermore, electrophysiological studies have shown that the dominant effect of these enkephalins on preoptic and hypothalamic neurons is an inhibition of neuronal activities in the male japanese quail. the hypothalamus and preoptic area are known to be involved in the control of male reproductive behaviors, such as aggressive and sexual behaviors. to determine the ...19979057316
apolipoprotein a-1 of japanese quail: cdna sequence and modulation of tissue expression by cholesterol feeding.apolipoprotein (apo) a-1 cdna was amplified by the reverse-transcriptase-polymerase chain reaction (rt-pcr). primers were synthesized according to the nucleotide sequence of chicken apo a-1, and the identity of apo a-1 cdna was confirmed by comparing with the n-terminal amino acid sequence. the open reading frame of apo a-1 cdna consists of 795 nucleotides, and it is capable of coding a polypeptide of 264 amino acids. a comparison between quail and chicken apo a-1 revealed 94.5% homology in the ...19979058967
divergent selection for body weight and yolk precursor in coturnix coturnix japonica. 12. heterosis in reciprocal crosses between divergently selected lines.a selection experiment was started using japanese quail to study the genetics of bw and plasma yolk precursor (measured by total plasma phosphorus; tpp). lines were divergently selected for 4-wk bw (hw and lw) or plasma tpp (hp and lp). sublines of hw were developed by continuing to select the males for increased 4-wk bw while selecting the females for increased (hw-hp line) or decreased (hw-lp line) tpp. the purpose of the present study was to determine the inheritance of traits associated with ...19979068041
ease of capture in japanese quail of two lines divergently selected for adrenocortical response to immobilization.divergent lines of japanese quail have been genetically selected over several generations for a reduced (low stress, ls) or an exaggerated (high stress, hs) plasma corticosterone response to brief mechanical restraint. female quail were housed in one mixed-line group (18ls + 18 hs) in one of the top-tier compartments of a brooder. at 32 d of age, the quail were removed individually by the experimenter, their identity and position in the order of capture were noted, and then they were placed in a ...19979068046
effects of vasotocin on aggressive behavior in male japanese quail. 19979071374
intestinal growth in altricial european starling (sturnus vulgaris) and precocial japanese quail (coturnix coturnix japonica). a morphometric and cytokinetic study.this paper introduces the comparison of altricial and precocial birds as a model system for the study of patterns of intestinal growth. it reports on comparative morphometric and cytokinetic studies of intestinal growth in altricial european starling (sturnus vulgaris) and precocial japanese quail (coturnix coturnix japonica). morphometric data at five gut segments of neonates and adults of both species are provided to evaluate the growth of the intestine. a double labelling technique combining ...19969078400
existence of parvalbumin and biochemical characterization in quail and pigeon skeletal muscles with different fiber type compositions.the localization of parvalbumin was determined in skeletal muscles with different fiber type compositions from quails (coturnix japonica) and pigeons (columba livia) by sandwich elisa. the biochemical profiles of these muscles were evaluated by the assay of total lactate dehydrogenase (ldh) activity as well as the ldh isozymes for anaerobic metabolism, and by the analysis of myoglobin for aerobic metabolism. the quail fast posterior latissimus dorsi (pld) with a lower myoglobin content and highe ...19979097460
copulation activates fos-like immunoreactivity in the male quail forebrain.it has been demonstrated using fos immunocytochemistry that copulation activates specific cell populations in the mammalian brain. prior to this study, no similar work has been carried out in birds. in mammals, fos has identified brain circuits activated by genital (penile)/somatosensory and by olfactory/vomeronasal stimuli. such inputs, of course, should play little or no role in birds (no penis, little or no role for olfaction) and a differential responsiveness could therefore be expected. mal ...19979105572
aromatase inhibition blocks the activation and sexual differentiation of appetitive male sexual behavior in japanese quail.two experiments investigated the role of estrogens in the activation and sexual differentiation of appetitive sexual behavior (asb) in japanese quail (coturnix japonica) as measured by a learned social proximity response. injection of the aromatase inhibitor r767 13 in castrated, testosterone (t)-treated male quail completely suppressed asb, confirming that, like consummatory sexual behavior, asb is mediated by t aromatization. asb is not observed in female quail, even if they are treated with t ...19979106677
rnase a activity in japanese quail oocytes.the presence of rnase a activity was studied in vitro in homogenates of quail oocytes and early embryos using [3h]poly(u) as a substrate. the activity was measured by adsorption of the undegraded substrate onto de-81 filter paper discs and by chromatographic separation on a sephadex g-50 column. rnase a activity examined by these methods was almost undetectable in quail previtellogenic, vitellogenic and ovulated oocytes as well as in the embryos from laid eggs. it is estimated to be about 1.1 x ...19969117282
lipoprotein and apoprotein profiles of hyperlipidemic atherosclerosis-prone japanese quail.the purpose of this study was to characterize the lipoprotein and apoprotein profiles of hyperlipidemic atherosclerosis-prone (hap) japanese quail. hap and commercially available (ca) japanese quail were fed either a semi-purified diet containing 1% cholesterol or a cholesterol-free diet for two weeks. the lipoproteins of ca and hap quail fed cholesterol-free diet were composed of two fractions: densities ranging from 1.02 to 1.09 and from 1.09 to 1.21. the lipoprotein distribution patterns obta ...19979151240
c-fos expression in the putative avian suprachiasmatic nucleus.c-fos induction was investigated as a potential component in the avian photic entrainment pathway and as a possible means of locating the central pacemaker in birds. in both quail (coturnix coturnix japonica) and starlings (sturnus vulgaris) exposure to 1 h of light induced fos-lir in the visual suprachiasmatic nucleus but not in the medial suprachiasmatic nucleus. however, the degree of c-fos induction in the visual suprachiasmatic nucleus was similar at different circadian times despite the fa ...19979163930
the behavior of the japanese or domestic quail coturnix japonica.this paper reviews the literature pertaining to the behavior of the japanese or domestic quail coturnix japonica. details are given of the classification, characteristics, domestication and the economic and research potential of the species. further sections deal with sensation and perception (including taste and smell, vision and hearing), maintenance behavior (including feeding and drinking, dust bathing and thermoregulation), development and aging (including vocalization, filial imprinting, s ...19979168263
comparative toxicity of polychlorinated biphenyls to japanese quail (coturnix c. japonica) and american kestrels (falco sparverius).polychlorinated biphenyls (pcbs) and related halogenated hydrocarbons bioaccumulate to high concentrations in top predators, such as raptorial birds, yet little is known of pcb toxicity to such species. this study explored several aspects of both the acute and chronic response of american kestrels (falco sparverius) to three purified pcb congeners and a commercial mixture, aroclor 1254, and compared the response to that of the japanese quail (coturnix c. japonica), a more studied species known t ...19979169061
regulation of the neural crest cell fate by n-myc: promotion of ventral migration and neuronal differentiation.during neural crest development in avian embryos, transcription factor n-myc is initially expressed in the entire cell population. the expression is then turned off in the period following colonization in ganglion and nerve cord areas except for the cells undergoing neuronal differentiation. this was also recapitulated in the culture of japanese quail neural crest, and the cells expressing n-myc eventually coincided with those expressing neurofilaments. these findings suggested that n-myc is inv ...19979169842
differences in the sexual conditioned behavior of male and female japanese quail (coturnix japonica).the conditioned responses of male and female japanese quail (coturnix japonica) were compared in a pavlovian conditioning procedure in which presentation of a brief conditioned stimulus was immediately followed by the release of a copulation partner. male quail vigorously approached the conditioned stimulus and were much more likely to enter the compartment housing their copulation partner than were female birds (experiment 1). in females, sexual conditioning resulted in increased squatting (exp ...19979170278
oxygen consumption and vital organ masses in young growing quail (coturnix coturnix japonica). 19979179319
identification of catecholaminergic inputs to and outputs from aromatase-containing brain areas of the japanese quail by tract tracing combined with tyrosine hydroxylase immunocytochemistry.in the quail brain, aromatase-immunoreactive (aro-ir) neurons located in the medial preoptic nucleus (pom) and caudal paleostriatum ventrale/nucleus accumbens/nucleus striae terminalis complex (pvt/nac/nst) receive catecholaminergic inputs identified by the presence of tyrosine hydroxylase-immunoreactive (th-ir) fibers and punctate structures. the origin of these inputs was analyzed by retrograde tracing with cholera toxin b subunit (ctb) or red latex fluospheres (rlf) combined with th immunocyt ...19979183702
short latency vestibular evoked potentials in the japanese quail (coturnix coturnix japonica).short-latency vestibular-evoked potentials to pulsed linear acceleration were characterized in the quail. responses occurred within 8 ms following the onset of stimuli and were composed of a series of positive and negative peaks. the latencies and amplitudes of the first four peaks were quantitatively characterized. mean latencies at 1.0 g ms-1 ranged from 1265 +/- 208 microseconds (p1, n = 18) to 4802 +/- 441 microseconds (n4, n = 13). amplitudes ranged from 3.72 +/- 1.51 microv (p1/n1, n = 18) ...19979190045
unconditional discrimination as a paradigm for investigating visual processing in the avian brainstem.visual discrimination between colors and patterns was studied in telencephalectomized chicks of japanese quail lines that were artificially selected for early approach preferences for particular colors and patterns. since these preferences are not conditional on prior learning, they provide an effective experimental paradigm to study visual discrimination without reliance on acquired stimulus discrimination. the data indicate that the quail's brainstem-thalamus complex is sufficient for relative ...19979199697
standard values for reproductive and clinical chemistry parameters of japanese quail.historical control data of japanese quail collected from reproduction studies conducted at the federal institute for health protection of consumers and veterinary medicine between 1988 and 1994 are presented in this paper. reproductive and clinical chemistry data from control animals of 10 ecotoxicological studies are summarized and discussed to develop a normal data base of this species. the data obtained were compared to the control reproductive parameters of bob-white quail and mallard ducks ...19979200886
maternal thyroid hormones in japanese quail eggs and their influence on embryonic development.we addressed the relationship between the thyroid status of hens and the thyroid hormone content of their eggs, as well as the influences of egg hormones on embryonic development. methods for measuring thyroid hormones in egg yolk were verified by demonstrating consistency in the recovery of yolk thyroid hormones following a methanol/chloroform extraction and in the measurement of thyroid hormones by ria for a range of hormone concentrations in yolk extracts. untreated hens produced eggs with yo ...19979245523
antioxidant enzymes and atherosclerosis in japanese quail: heritability and genetic correlation estimates.to estimate, in male quail susceptible to atherosclerotic plaque formation (sus) fed a regular diet and an atherogenic diet, the genetic and phenotypic parameters associated with antioxidant enzymes and atherogenesis.19979251579
perceptual compensation for coarticulation by japanese quail (coturnix coturnix japonica).when members of a series of synthesized stop consonants varying in third-formant (f3) characteristics and varying perceptually from /da/ to /ga/ are preceded by /al/, human listeners report hearing more /ga/ syllables than when the members of the series are preceded by /ar/. it has been suggested that this shift in identification is the result of specialized processes that compensate for acoustic consequences of coarticulation. to test the species-specificity of this perceptual phenomenon, data ...19979265760
a novel and simple technique for ectopic transplantation of the pituitary gland.sites for ectopic transplantation of the pituitary include the kidney capsule of mammals, the anterior eye chamber, the so-called hypophysiotropic area of the brain, the third cerebral ventricle, and the tail of the amphibian tadpole. transplantation of pituitary in the kidney capsule of mammals is a simple technical procedure but most nonmammalian species do not offer such a convenient site. transplantation of pituitaries at other ectopic sites involves technical sophistication and cannot be un ...19979268611
comparison between oogenesis and related ovarian structures in a reptile, pseudemys scripta elegans (turtle) and in a bird coturnix coturnix japonica (quail).the aspect of the oogonia during their premitotic dna synthesis and of the premeiocytes during their premeiotic dna synthesis was studied in turtles by autoradiography, after injection of 3h-thymidine. as in the adult laying quail, the intrafollicular oocytes of the adult turtle go through three successive stages: prelampbrush, lampbrush and postlampbrush. during the prelampbrush and lampbrush stage two kinds of nucleoli exist: peripheral and central. in contrast to avian yolk, during its final ...20069269708
differential effects of d1 and d2 dopamine-receptor agonists and antagonists on appetitive and consummatory aspects of male sexual behavior in japanese quail.pharmacological studies in japanese quail based on behavioral tests with a variety of dopaminergic compounds suggest that the activation of d2 dopamine receptors inhibits, and the activation of d1 dopamine receptors enhances, appetitive and consummatory components of male sexual behavior. this hypothesis was tested by studying the behavioral effects of specific d1 and d2 dopaminergic-receptor agonists and antagonists in castrated male japanese quail chronically treated with exogenous testosteron ...19979272666
quail cystatin: isolation and characterisation of a new member of the cystatin family and its hypothetical interaction with cathepsin b.quail cystatin, a new cysteine proteinase inhibitor protein of the cystatin superfamily, was purified from egg albumen of japanese quail coturnix coturnix japonica. amino acid sequencing and mass spectrometry revealed the complete 116 amino acid residue primary structure of a phosphorylated form (13,173 da). the inhibitor has a 90% sequence identity with chicken cystatin. its interaction with papain is rapid and tight (ki = 4.4 pm; k(on) = 1.8x10(7) m(-1) s(-1); k(off) = 0.8x10(-4) s(-1)) and ve ...19979276465
effect of growth rate and body mass on resting metabolic rate in galliform chicks.in this study, we asked whether within-species variation in chick resting metabolic rate was related to variation in growth and whether this relationship changed during development in three galliform species (turkey, meleagris gallopavo, guinea fowl, numida meleagris, and japanese quail, coturnix coturnix japonica). resting metabolic rate increased by a bi- or triphasic pattern with body mass. for each phase, the relationship between metabolic rate and growth was studied by residual analysis, wi ...19979279916
effects of dopamine agonists on appetitive and consummatory male sexual behavior in japanese quail.the effects of pharmacological manipulations of dopaminergic transmission on appetitive and consummatory aspects of male sexual behavior were investigated in castrated male japanese quail treated with exogenous testosterone. appetitive male sexual behavior was assessed by measuring a learned social proximity response and consummatory behavior was assessed by measuring copulatory behavior per se. the nonselective dopamine receptor agonist, apomorphine, inhibited in a dose-dependent manner both co ...19979300599
anatomically specific colocalization of nadph-diaphorase and choline acetyltransferase in the quail brainstem.on the basis of previous studies demonstrating a wide colocalization of nadph-diaphorase (nd) and choline acetyltransferase (chat) in mammalian and reptilian brainstem, nd histochemistry and chat immunocytochemistry have been combined to study the distribution of both markers in the mesopontine region of an avian species, the japanese quail (coturnix japonica). co-existence of the two neurochemical markers is present only in part of the system, namely, in the nucleus tegmentalis pedunculo-pontin ...19979300644
effect of gonadotrophin and sex steroid on the scotoresponses of day old chicks of japanese quail, coturnix coturnix japonica.luteinizing hormone (lh) and testosterone propionate (tp) were tested for their effects on the development of scotorefractoriness in japanese quail. day old chicks of both the sexes were divided into four groups and treated with normal saline, lh (1 microg/100 g body weight) and two doses of tp (100 microg/100 g body weight- tp1 and 1 mg/100 gm body weight- tp2) over a periods of 14 weeks. in the male chicks, compared to control, lh treatment advanced and low dose of tp suppressed the developmen ...19979328228
photoperiodically driven changes in fos expression within the basal tuberal hypothalamus and median eminence of japanese quail.the rapid photoperiodic response in japanese quail is so precise that it allows neural analyses of how photoperiodic information is transduced into an endocrine response. after transfer from short [sd; 6l:18d (6:18 hr light/dark cycle)] to long (ld; 20l:4d) days, luteinizing hormone (lh) first rises 20 hr after dawn. using fos immunocytochemistry, we examined the basal tuberal hypothalamus (bth) to determine the relationship between brain cell activation and the first endocrine changes. two sepa ...19979348357
bh (black at hatch) gene appears to be expressed in melanocytes of feather germs in the japanese quail (coturnix coturnix japonica).the bh (black at hatch) gene was examined to determine whether it is expressed in plumage melanocytes by analyzing pigmentation patterns of bh melanocytes placed in the micro-environment of the feather germs of quail embryos with pink eyes. these host quails genetically lack a large part of plumage melanin. the bh locus in these almost white quails is wild-type. when bh neural crest cells were transplanted orthotopically into the host embryos, wild-type and bh/+ melanocytes, which differentiated ...19979352198
transport characteristics of the colonic epithelium of the japanese quail (coturnix coturnix).the colon of the domestic fowl sustains a reabsorptive na+ current on both high- and low-sodium diets. however, there is a marked shift in the apical transport step under these two extreme conditions, from amino acid/hexose cotransport on high-salt diets to amiloride-sensitive na+ channels on low-salt diets. the present experiments were performed to study colonic na+ transport in another galliform species, the japanese quail (coturnix coturnix). birds were maintained on a commercial game feed co ...19979366053
morphological evidence of ototoxicity of the iron chelator deferoxamine.recent reports of the role of iron-catalyzed free radical formation in gentamicin ototoxicity and the successful attenuation of gentamicin ototoxicity by iron chelators led us to re-examine experimental material from a previously unpublished study of deferoxamine. deferoxamine was injected i.m. into adult japanese quail at either 300 or 750 mg/kg body weight for 30 days. examination of sections from the basilar papilla at the light microscope level indicated that supporting cells were damaged af ...19979367228
gicerin, a cell adhesion molecule, participates in the histogenesis of retina.gicerin is a novel cell adhesion molecule that belongs to the immunoglobulin superfamily. gicerin protein adheres to neurite outgrowth factor (nof), an extracellular matrix protein in the laminin family, and also exhibits homophilic adhesion. heterophilic adhesion of gicerin to nof is thought to play an active role in neurite outgrowth of developing retinal cells in vitro. in this study, we examined the adhesion activity of gicerin during the retinal development of japanese quail using an antibo ...19979369150
neuroendocrine regulation of gnrh and behavior during aging in birds.avian species exhibit a great variety of life-long patterns in reproduction. japanese quail are relatively short lived and undergo an age-related loss of reproductive function, making this species an excellent model for the study of the basic biology of aging. because individuals age at variable rates, sexual behavior has provided a useful index to assess reproductive status of individuals of the same chronological age. further, exogenous testosterone restores sexual behavior in reproductively s ...19979370213
induction of the zenk protein after sexual interactions in male japanese quail.we mapped cells immunoreactive (ir) for the protein encoded by the immediate early gene zenk in the brains of male japanese quail after they engaged in either appetitive or consummatory sexual behavior (i.e. copulation). castrated males treated with testosterone were either allowed to copulate with a female or exhibited a learned social proximity response indicative of appetitive sexual behavior, and were compared with control males in their home cage or in the experimental chamber but not exhib ...19979376540
a direct comparison of photoperiodic time measurement and the circadian system in european starlings and japanese quail.the extent to which circadian rhythms are involved in photoperiodic time measurement in quail is enigmatic, and earlier investigations have produced results consistent with an hourglass clock or one involving damped circadian oscillators. to address the problem further, the present authors carried out a direct comparison between the clocks in quail and those in starlings. starlings possess strongly self-sustaining circadian oscillators. in experiment 1, comparisons of testicular growth were made ...19979376642
plasmodium forresteri n. sp., from raptors in florida and southern georgia: its distinction from plasmodium elongatum morphologically within and among host species and by vector susceptibility.plasmodium forresteri n. sp. naturally infects eastern screech-owls (otus asio), great horned owls (bubo virginianus), barred owls (strix varia), bald eagles (haliaeetus leucocephalus), red-shouldered hawks (buteo lineatus), broad-winged hawks (buteo platypterus), and red-tailed hawks (buteo jamaicensis) in florida and southern georgia. schizonts occur in mature or nearly mature erythrocytes, produce 2-6 merozoites arranged most commonly in fan or cruciform configuration, with mean dimensions am ...19979379302
the annual testicular cycle of the domestic quail (coturnix coturnix japonica).a morphometric study was conducted on the testis of the domestic quail coturnix coturnix japonica to determine testicular kinetics. we investigated the variability along the year of testicular parameters such as seminiferous tubule diameter, germinal epithelium height and amount of meiotic figures of maturing spermatids in the seminiferous epithelium and of sperm in the tubular lumen. the results of morphometric analysis showed the occurrence of an annual testicular cycle defined by four distinc ...19979400052
predominant expression of a z-chromosome-linked immunoglobulin superfamily gene, zov3, in steroidogenic cells of ovarian follicles and in embryonic gonads of chickens.a cdna clone, pzov3, was isolated from the cdna library of immature chicken ovaries and its gene was mapped to the middle of the short arm of the z chromosome. the cdna sequence suggests that zov3 is a novel member of the immunoglobulin superfamily. cdna clones of homologues of chicken zov3 were also obtained from japanese quail and pigeon. northern blot hybridization suggests that the high-level expression of the zov3 gene is restricted to the gonads: embryonic, immature and mature ovaries, and ...19979404001
conditioned place preference in 12-day-old japanese quail.four experiments assessed the ability of 12-day-old japanese quail to learn a conditioned place preference (cpp). in experiment 1, immature quail learned to prefer a place paired with normal food over a place paired with tainted food. experiment 2 indicated that this kind of learning can be achieved with as few as 2 days of training. it was discovered in experiment 3 that place preferences can be established with exposure to only one hedonic event. quail learned to prefer a chamber paired with e ...19979413672
filtering effect of cone oil droplets detected in the p-iii response spectra of japanese quail.while absorption spectra of bird cone visual pigments have been well studied, physiological study of bird cone cells has been less advanced owing to their small sizes. we measured the p-iii components of electroretinograms (erg) from isolated retinas of japanese quail. we recorded responses to monochromatic flashes of equal photon numbers, and found that the shape of the response spectrum is dependent on the incident direction of the flashes. the spectrum obtained with the flashes from the corne ...19979415363
proteolytic enzymes in yolk-sac membrane of quail egg. purification and enzymatic characterisation.degradation of yolk protein is essential for the early development of the avian embryo. in japanese quail (coturnix coturnix japonica), proteolysis in the surrounding tissue of the yolk, the yolk-sac membrane, can be inhibited by class-specific inhibitors of cysteine proteinases as well as of aspartic proteinases. purification of the enzymes leads to one cysteine proteinase and one aspartic proteinase with an apparent molecular mass of 29 kd and 44 kd, respectively. both enzymes were purified in ...19979418005
a direct dopaminergic control of aromatase activity in the quail preoptic area.in the quail preoptic area (poa) anatomical and pharmacological data suggest that catecholamines may be implicated in the control of testosterone (t) aromatization into estrogens. the biochemical mechanism(s) mediating this control of the enzyme activity is (are) however unexplored. the present studies were carried out to investigate whether the catecholamines, dopamine (da) and norepinephrine (ne) are able to directly affect aromatase activity (aa) measured during in vitro incubations of poa ho ...19979449211
clinical and metabolic correction of pompe disease by enzyme therapy in acid maltase-deficient quail.pompe disease is a fatal genetic muscle disorder caused by a deficiency of acid alpha-glucosidase (gaa), a glycogen degrading lysosomal enzyme. gaa-deficient (amd) japanese quails exhibit progressive myopathy and cannot lift their wings, fly, or right themselves from the supine position (flip test). six 4-wk-old acid maltase-deficient quails, with the clinical symptoms listed, were intravenously injected with 14 or 4.2 mg/kg of precursor form of recombinant human gaa or buffer alone every 2-3 d ...19989466978
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