Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [unfortunately without effectiveness: chlamydia eradication after infarct]. | 2002 | 12014269 | |
| mycoplasma pneumoniae and chlamydia pneumoniae cause lower respiratory tract disease in paediatric patients. | new studies suggest that mycoplasma pneumoniae and chlamydia pneumoniae play a more significant role as causes of lower respiratory tract infections in childhood than was previously thought. in particular, the incidence of infections caused by these pathogens is high in children aged less than 5 years, the infections themselves seem to be a possible cause of wheezing, and may present a more complicated course when not treated with adequate antimicrobial agents. however, despite the increasing pa ... | 2002 | 12015465 |
| chlamydia pneumoniae infection of endothelial cells induces transcriptional activation of platelet-derived growth factor-b: a potential link to intimal thickening in a rabbit model of atherosclerosis. | smooth muscle cell (smc) proliferation and intimal thickening are hallmark features of atherosclerotic disease, and chlamydia pneumoniae may contribute to atherogenesis by imparting biological effects on smcs. an in vitro endothelial cell model and a normocholesterolemic rabbit model were used to test the hypothesis that infection with c. pneumoniae induces smc growth factor production, smc proliferation, and aortic intimal thickening. using reverse-transcriptase polymerase chain reaction, it wa ... | 2002 | 12023768 |
| effect of macrolide antibiotics on human endothelial cells activated by chlamydia pneumoniae infection and tumor necrosis factor-alpha. | this study investigated the potential anti-inflammatory activity of 3 macrolide antibiotics, clarithromycin, roxithromycin, and azithromycin, in an in vitro model of transendothelial migration (tem). human umbilical vein endothelial cells (huvecs) were seeded in transwell inserts, treated with serial dilutions of the antibiotics, and infected with chlamydia pneumoniae or stimulated with tumor necrosis factor (tnf)-alpha. in huvecs infected with c. pneumoniae or stimulated with tnf-alpha, both az ... | 2002 | 12023769 |
| parachlamydiaceae: potential emerging pathogens. | parachlamydiaceae, which naturally infect amoebae, form a sister taxon to the chlamydiaceae on the basis of the chlamydia-like cycle of replication and 80% to 90% homology of ribosomal rna genes. because intra-amoebal growth could increase the virulence of some intracellular bacteria, parachlamydiaceae may be pathogenic. arguments supporting a pathogenic role are that chlamydia pneumoniae, a well-recognized agent of pneumonia, was shown to infect free-living amoebae and that another member of th ... | 2002 | 12023921 |
| species specific chlamydiae antibodies in voluntary blood donors of delhi. | different species of genus chlamydia have been associated with ocular, genitourinary and respiratory infections, and coronary artery disease. since the majority of these infections remain asymptomatic or subclinical, antibodies may be present in apparently healthy individuals, and the determination of species specific chlamydia antibodies in a healthy population may reflect exposure. we therefore screened the sera of healthy blood donors for species specific chlamydia antibodies by microimmunofl ... | 2001 | 12025256 |
| [biochemical risk factor for atherosclerosis in young men. preliminary report]. | atherosclerotic damage of cardiovascular system, including kidneys, is an increasing problem not only in the modern cardiology but also in nephrology and dialysotherapy. the purpose of our study was to evaluate the frequency of particular biochemical risk factors for atherosclerosis (rffa) in young men being over-pressed with psychological stress because of decisive character of their professional job. there were 68 men in mean age 33.3 +/- 7.4 years, being employed in the state administration f ... | 2001 | 12026514 |
| chlamydia pneumoniae infections in patients with community-acquired pneumonia in slovenia. | it is well known that chlamydia pneumoniae is an important respiratory pathogen. in this study, the prevalence of specific antibodies to c. pneumoniae in hospitalized patients with community-acquired pneumonia (943 adult females, 990 adult males and 185 children) was evaluated over a period of 7 y (1993-99). two serum samples were obtained from all of the patients: 1 on admission and the other 3 weeks later. the specimens were tested for c. pneumoniae igg, igm and iga antibodies by means of a mi ... | 2002 | 12030388 |
| quantitative detection of respiratory chlamydia pneumoniae infection by real-time pcr. | real-time pcr was evaluated as a quantitative diagnostic method for chlamydia pneumoniae infection using different respiratory samples. real-time pcr had efficiency equal to or better than that of nested touchdown pcr. this study confirmed sputum as the best sampling material to detect an ongoing c. pneumoniae infection. | 2002 | 12037108 |
| infections and body weight: an emerging relationship? | 2002 | 12037642 | |
| [submitral annular aneurysm, postpartum cardiomyopathy, and anti-chlamydia pneumoniae antibodies in niamey (niger)]. | idiopathic annular submitral left ventricular aneurysm has been described mainly in young africans living in tropical countries. association with peripartum cardiomyopathy has been previously pointed out. the purpose of this report is to describe 3 patients with idiopathic annular submitral left ventricular aneurysm identified in a series 50 patients with peripartum cardiomyopathy in niamey, republic of niger. anti-chlamydia pneumoniae antibody status was determined in all 50 patients using the ... | 2002 | 12038186 |
| roxithromycin treatment prevents progression of peripheral arterial occlusive disease in chlamydia pneumoniae seropositive men: a randomized, double-blind, placebo-controlled trial. | evidence has been provided that the atherosclerotic process may be associated with chronic infection with chlamydia pneumoniae. the effect of antibiotic treatment on peripheral arterial occlusive disease has not been investigated yet. | 2002 | 12045171 |
| in vitro activity of levofloxacin against contemporary clinical isolates of legionella pneumophila, mycoplasma pneumoniae and chlamydia pneumoniae from north america and europe. | to assess the activities of levofloxacin and the comparator agents erythromycin, clarithromycin, azithromycin and doxycycline against atypical respiratory pathogens. | 2002 | 12047413 |
| chlamydia pneumoniae, helicobacter pylori and cytomegalovirus infections and the risk of peripheral arterial disease in young women. | sero-epidemiological case control studies have observed positive relations between infections with chlamydia pneumoniae, helicobacter pylori or cytomegalovirus (cmv) and the occurrence of coronary artery disease (cad) and stroke. moreover, positive relations between 'infection burden' and cad and the role of inflammation have recently been described. however, the relations between infection, inflammation and the occurrence of peripheral arterial disease (pad) have not been reported so far. we pe ... | 2002 | 12048133 |
| chlamydia pneumoniae infection is not involved in carotid artery stenosis. | recent studies have suggested the existence of a close relationship between chlamydia pneumoniae infection and atherosclerosis. however, it has been speculated that c. pneumoniae infection is not associated with early atherosclerosis but with advanced atherosclerosis. in the present study, we test this hypothesis. in 524 consecutive patients who underwent cerebral angiography were recruited for the study. from the films obtained during angiography, percent stenosis of neck internal carotid arter ... | 2002 | 12048135 |
| monoclonal antibody of igg isotype against a cross-reactive lipopolysaccharide epitope of chlamydia and salmonella re chemotype enhances infectivity in l-929 fibroblast cells. | a murine monoclonal antibody (mab) 202d7 of igg3 isotype recognizes a lipopolysaccharide (lps) epitope of chlamydia spp. and cross-reacts with the re chemotype lps of salmonella and escherichia coli. the antibody exhibits strong complement activating properties and stimulates phagocytosis of salmonella enterica serovar minnesota re mutant by murine macrophages. salmonella re mutants are non-invasive for cell monolayers but still can enter and replicate in l-929 murine fibroblast cells. the entry ... | 2002 | 12052561 |
| chlamydia pneumoniae seropositivity is associated with increased plasma levels of soluble cellular adhesion molecules in community-dwelling subjects: the shimanami health promoting program (j-shipp) study. | in vitro studies have demonstrated that chlamydia pneumoniae infection of the endothelium increases the expression of adhesion molecules and chemokines, indicating that c pneumoniae infection affects the adhesion and recruitment of leukocytes to the endothelium, which is believed to be involved in the initial steps of atherosclerosis. however, whether chronic c pneumoniae infection increases these molecules in vivo has not been elucidated. | 2002 | 12052977 |
| [effect of chlamydia pneumoniae infection on carotid atherosclerosis development]. | recently, a growing number of epidemiological, histopathological and microbiological studies have shown that chronic chlamydia pneumoniae (c. pneumoniae) infection accelerates the progression of atherosclerosis of carotid and cerebral arteries and thus could constitute a risk factor for stroke. we present a number of mechanisms postulated in recent papers that link c. pneumoniae infection with the development of atherosclerosis. the one most important seems to be the effect of activation of nucl ... | 2002 | 12053604 |
| biological effects of secretory phospholipase a(2) group iia on lipoproteins and in atherogenesis. | secretory phospholipase a(2) group iia(spla(2) iia) can be produced and secreted by various cell types either constitutionally or as an acute-phase reactant upon stimulation by proinflammatory cytokines. the enzyme prefers phosphatidylethanolamine and phosphatidylserine as substrates. one important biological function may be the hydrolytic destruction of bacterial membranes. it has been demonstrated, however, that spla(2) can also hydrolyse the phospholipid monolayers of high density lipoprotein ... | 2002 | 12059982 |
| pneumonia in children. | 2002 | 12063383 | |
| [chlamydia pneumoniae and cytomegalovirus in degenerative aortic valve stenoses]. | recent evidence suggests a causal relationship between inflammatory as well as infectious pathomechanisms and valvular degeneration. based on the concept of chronic chlamydia pneumoniae and cytomegalovirus (cmv) infections, and of variable stressors working on valvular microecology, the present study sought to assess the presence of the specific chlamydial heat shock protein (chsp) 60, of cmv, of macrophages and of the human homologue hhsp60. serial sections of high-grade degenerated native (n = ... | 2002 | 12063700 |
| does chlamydia pneumoniae have a role in atherosclerosis? | 2002 | 12063818 | |
| clinical presentation of community-acquired chlamydia pneumoniae pneumonia in adults. | to investigate the clinical presentation of community-acquired chlamydia pneumoniae pneumonia in adults. | 2002 | 12065338 |
| mycoplasma pneumoniae and chlamydia pneumoniae in asthma: effect of clarithromycin. | to determine the effect of clarithromycin therapy in patients with asthma. | 2002 | 12065339 |
| identification of chlamydia pneumoniae-derived mouse cd8 epitopes. | chlamydia pneumoniae is a common intracellular human pathogen that has been associated with several severe pathological conditions, including coronary heart disease and atherosclerosis. there is no vaccine against c. pneumoniae infection, but cd8(+) t cells have been shown to be crucial for protection during experimental infection. however, the effector functions and epitope specificity of the protective cd8(+) t cell remain unknown. the aim of this study was to identify c. pneumoniae-derived mo ... | 2002 | 12065471 |
| cytokines induce indoleamine 2,3-dioxygenase expression in human atheroma-asociated cells: implications for persistent chlamydophila pneumoniae infection. | this study shows that vascular smooth muscle cells express significantly higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (ido) activity than endothelium or mononuclear cells. since ido activity is linked to persistent chlamydophila pneumoniae infection, our results suggest that smooth muscle cells may be an important reservoir of that organism in atherosclerosis. | 2002 | 12065543 |
| chlamydia in anterior ischemic optic neuropathy. | there is an increasing body of evidence linking the common respiratory human pathogen chlamydia pneumoniae with atherosclerosis and other vascular disorders. our research was designed to investigate the association of this organism with anterior ischemic optic neuropathy (aion), representing an acute ischemic disorder of the optic nerve head. sera were examined of 14 consecutive patients with aion and of 14 age- and sex-matched control subjects with noncardiovascular, nonpulmonary disorders. ant ... | 2002 | 12065860 |
| a survey of infectious agents as risk factors for primary sclerosing cholangitis: are chlamydia species involved? | the aetiology of primary sclerosing cholangitis (psc) is unknown, and the role of micro-organisms has been studied only to a limited extent. we tested the hypothesis that past or persisting infection with common viruses or atypical bacteria might play a role in genetically susceptible hosts. | 2002 | 12072598 |
| chlamydia pneumoniae infection among healthy children and children hospitalised with pneumonia in greece. | chlamydia pneumoniae has been recognized as a cause of respiratory tract infection in humans, and its prevalence has been shown to vary among different age groups and populations. the prevalence of chlamydia pneumoniae antibody was determined by serological investigation in 343 healthy children and in 77 children consecutively hospitalised for pneumonia in southwestern greece. seventy-eight (22.7%) healthy children had igg chlamydia pneumoniae titers > or =1/8. the prevalence of chlamydia pneumo ... | 2002 | 12072942 |
| association between past infection with chlamydia pneumoniae and body mass index, low-density lipoprotein particle size and fasting insulin. | chlamydia pneumoniae infection has been linked to the development of coronary heart disease (chd), but its relationship to chd risk factors is less clear. | 2002 | 12075572 |
| relative frequency of haemophilus influenzae type b pneumonia in chinese children as evidenced by serology. | it is commonly held that haemophilus influenzae pneumonia among children in asia is mostly caused by serotypes other than b (hib). if so, hib conjugate vaccines would play little role in the prevention of pneumonia. in two prospective series of children hospitalized for pneumonia in china, the causative agents were searched for with a wide panel of microbiologic assays. | 2002 | 12075755 |
| review of evidence for a connection between chlamydia pneumoniae and atherosclerotic disease. | established risk factors account for no more than 50% of coronary artery disease cases; therefore, the search continues for other modifiable risk factors. in recent years, there has been renewed interest in the infectious theory of atherosclerosis. chlamydia pneumoniae has been implicated as a potential cause of atherosclerotic disease. | 2002 | 12075941 |
| chlamydophila pneumoniae specific antibodies in thai patients with myocardial infarction. | to investigate the correlation between chlamydia pneumoniae infection and acute myocardial infarction (ami), a total of 101 serum specimens collected from patients with ami admitted to the coronary care unit, bhumibol adulyadej hospital, and serum specimens collected from healthy blood donors (control group) were examined by using the micro-immunofluorescence test. c. pneumoniae antibody-positive cases were found in 52 (52%) patients, consisting of 30 males and 22 females, though no significant ... | 2002 | 12082308 |
| seroprevalence of chronic chlamydia pneumoniae infection in patients affected by chronic stable asthma. | to evaluate the seroprevalence of chlamydia pneumoniae and age, gender and smoking habits in stable asthmatic patients. | 2002 | 12084104 |
| infections and their role in atherosclerotic vascular disease. | complications of atherosclerosis are the leading cause of mortality in developed countries, and infections may play a role in the pathogenesis. numerous studies have addressed this issue in the past decade. | 2002 | 12085725 |
| molecular evidence to support the expansion of the hostrange of chlamydophila pneumoniae to include reptiles as well as humans, horses, koalas and amphibians. | the chlamydiales are a family of unique intracellular pathogens that cause significant disease in humans, birds and a wide range of animal hosts. of the currently recognized species, chlamydophila (previously chlamydia) pneumoniae, unlike the other chlamydial species, has been previously considered to be solely a pathogen of humans, causing significant respiratory disease and has also been strongly connected with cardiovascular disease. here we report the finding that strains of c. pneumoniae ar ... | 2002 | 12086181 |
| systemic inflammation, chlamydia pneumoniae dna in circulating leukocytes and coronary atherosclerosis. | earlier studies have suggested that c. pneumoniae may be involved in the progression of atherosclerosis by contributing to the pathogenesis of inflammation in the vessel wall. the aim of the present study was to determine the prevalence of c. pneumoniae dna in circulating white blood cells of patients with ischaemic heart disease and to correlate these findings with the extent of coronary atherosclerosis and serum markers of inflammation. | 2002 | 12088179 |
| comparison of an industry-derived lcx chlamydia pneumoniae pcr research kit to in-house assays performed in five laboratories. | in a multicenter comparison of pcr assays utilizing 120 quantitated samples of 16 chlamydia pneumoniae isolates, an lcx research-use-only (ruo) pcr developed by abbott laboratories demonstrated 100% sensitivity on 48 samples with >1 copy of dna per microl of specimen. the sensitivities of five in-house pcr assays ranged from 54 to 94% for the same samples. all six assays showed decreased sensitivities as the dna copy numbers of the samples decreased. overall, sensitivities ranged from 68% for th ... | 2002 | 12089248 |
| eradication of chlamydia pneumoniae from coronary artery endothelium. | 2002 | 12090910 | |
| performance of three microimmunofluorescence assays for detection of chlamydia pneumoniae immunoglobulin m, g, and a antibodies. | the microimmunofluorescence (mif) test is considered the "gold standard" for laboratory diagnosis of acute and chronic chlamydia pneumoniae infection. the performance of a mif test based on c. pneumoniae antigen from washington research foundation (wrf) was compared with those of assays from labsystems (lab) and mrl diagnostics (mrl) by investigation of sera from three groups of patients: group i, 83 sera from 28 patients with atypical pneumonia; group ii, 37 sera from 16 patients with acute c. ... | 2002 | 12093682 |
| advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. | cardiovascular mortality is excessive in young adults with end-stage renal disease (esrd). the factors contributing to esrd-related vascular disease are incompletely understood. young adults with childhood-onset chronic renal failure (crf) are uniquely suited for risk factor assessment because of their long-term exposure at an age when vascular pathology in the general population is still minimal. | 2002 | 12093777 |
| chlamydia pneumoniae in atherosclerotic lesions of patients undergoing vascular surgery. | the pathophysiological implications of chlamydia pneumoniae in atherosclerotic lesions and its contribution to atherosclerotic complications remain unclear. therefore, the purpose of the present study was to evaluate whether or not there is an association between the presence of chlamydia pneumoniae in atherosclerotic lesions and the clinical manifestations as well as risk factors of atherosclerotic disease in patients undergoing vascular surgery. specimens from atherosclerotic arteries were col ... | 2002 | 12098020 |
| smoking, season, and detection of chlamydia pneumoniae dna in clinically stable copd patients. | the prevalence and role of chlamydia pneumoniae in chronic obstructive pulmonary disease (copd) remain unclear, and molecular methods of detection may help clarify this relationship. | 2002 | 12098361 |
| characterization of a secreted chlamydia protease. | chlamydiae are obligate intracellular bacteria that are important human pathogens. the chlamydia genomes contain orthologues to secretion apparatus proteins from other intracellular bacteria, but only a few secreted proteins have been identified. most likely, effector proteins are secreted in order to promote infection. effector proteins cannot be identified by motif or similarity searches. as a new strategy for identification of secreted proteins we have compared 2d-page profiles of [35s]-label ... | 2002 | 12102687 |
| identification of mek- and phosphoinositide 3-kinase-dependent signalling as essential events during chlamydia pneumoniae invasion of hep2 cells. | the ability of chlamydia pneumoniae to survive and cause disease is predicated on efficient invasion of cellular hosts. while it is recognized that chlamydial determinants are important for mediating attachment and uptake into non-phagocytic cells, little is known about the bacterial ligands and cellular receptors that facilitate invasion or host cell signal transduction pathways implicated in this process. we used transmission and scanning electron microscopy to demonstrate that attachment of b ... | 2002 | 12102690 |
| cd14 c(-260)-->t polymorphism, plasma levels of the soluble endotoxin receptor cd14, their association with chronic infections and risk of stable coronary artery disease. | we sought to investigate the association of cd14 genotype and plasma levels of soluble (s)cd14 with risk of stable coronary artery disease (cad), chronic infections and sensitive markers of systemic inflammation. | 2002 | 12103253 |
| predisposition to atherosclerosis by infections: role of endothelial dysfunction. | several microorganisms have been implicated in the pathogenesis of atherosclerosis. we hypothesized that infections may predispose to atherosclerosis by inflicting endothelial injury. | 2002 | 12105156 |
| failure to correlate c. pneumoniae with late onset alzheimer's disease. | 2002 | 12105327 | |
| determination of pcr efficiency in chelex-100 purified clinical samples and comparison of real-time quantitative pcr and conventional pcr for detection of chlamydia pneumoniae. | chlamydia pneumoniae infection has been detected by serological methods, but pcr is gaining more interest. a number of different pcr assays have been developed and some are used in combination with serology for diagnosis. real-time pcr could be an attractive new pcr method; therefore it must be evaluated and compared to conventional pcr methods. | 2002 | 12106506 |
| detection of chlamydia pneumoniae deoxyribonucleic acid in blood samples taken from coronary sinus after coronary angioplasty. | 2002 | 12106855 | |
| the detection of chlamydia pneumoniae in atherosclerotic plaques of australian subjects. | to determine whether the common respiratory pathogen, chlamydia pneumoniae, was associated with atherosclerotic plaques in australian subjects. | 2002 | 12109790 |
| cost-effective approaches to the treatment of community-acquired pneumonia in the era of resistance. | community-acquired pneumonia (cap) infects upwards of four million people in the us each year, of which 20% require subsequent hospitalisation. consequently, it is a large contributor to excessive healthcare resource consumption and cost. since the aetiology of cap is not identified in a majority of patients, treatment is often empiric, aimed at the most common causes, streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis, and the atypical pathogens (mycoplasma pneumoniae, chla ... | 2002 | 12109917 |
| clinical manifestations of atherosclerosis in an elderly population are related to plasma neopterin, ngal and endothelin-1, but not to chlamydia pneumoniae serology. | inflammatory mediators secreted by leukocytes are implicated in atherogenesis. chlamydia (c.) pneumoniae infection has been suggested as a trigger of this process. we investigated relationships between c. pneumoniae serology, inflammatory mediators and symptomatic cardiovascular disease in old age. | 2002 | 12110780 |
| identification and characterization of a novel chlamydia trachomatis reticulate body protein. | the genome of the obligate intracellular bacterium chlamydia trachomatis comprises 894 genes predicted by computer-based analysis. as part of a large-scale proteome analysis of c. trachomatis, a small abundant protein encoded by a previously unrecognized novel 204-bp open reading frame was identified by tandem mass spectrometry. no homology of this protein was observed to proteins from other organisms. the protein was conserved in c. trachomatis but not found in chlamydia pneumoniae. using prote ... | 2002 | 12113934 |
| aspirin inhibits chlamydia pneumoniae-induced nuclear factor-kappa b activation, cytokine expression, and bacterial development in human endothelial cells. | chlamydia pneumoniae has been associated with atherosclerosis. infection of vascular endothelial cells with c pneumoniae increases the expression of proatherogenic cytokines mediated by nuclear factor (nf)-kappab, a transcription factor. the present study was designed to test the effect of aspirin on c pneumoniae-induced nf-kappab activation, interleukin expression, and bacterial development in cultured human endothelial cells. | 2002 | 12117719 |
| positive chlamydia pneumoniae serology is associated with elevated levels of tumor necrosis factor alpha in patients with coronary heart disease. | infectious agents are possible stimulators of inflammation in atherogenesis. the aim of this study was to investigate if chlamydia pneumoniae and helicobacter pylori were associated with elevated levels of tumor necrosis factor alpha (tnfalpha) and interleukin-6 in coronary heart disease (chd) patients (n=193) and age- and sex-matched controls (n=193) as markers of increased inflammatory activity. c reactive protein (crp) and fibrinogen were also included. serologic status towards the two bacter ... | 2002 | 12119204 |
| an open, comparative pilot study of thiamphenicol glycinate hydrochloride vs clarithromycin in the treatment of acute lower respiratory tract infections due to chlamydia pneumoniae. | the aim of this study was to evaluate the efficacy and tolerability of thiamphenicol glycinate hydrochloride (tgh) i.m. versus clarithromycin in acute lower respiratory infections due to chlamydia pneumonia. 113 patients with suspected pneumonia were screened. 40 patients with igm and/or iga titers > or = 1:16 and/or igg titers > or = 1:512 were assigned to 10 days of treatment with tgh 1500 mg daily or clarithromycin 1000 mg daily. 34 patients were considered a clinical success. 33 patients wer ... | 2002 | 12120881 |
| recent clinical evidence of the efficacy and safety of thiamphenicol glycinate acetylcysteinate and thiamphenicol glycinate. | thiamphenicol is a broad-spectrum antimicrobial agent active against penicillin-resistant streptococcus pneumoniae, staphylococcus aureus visa strains, most methicillin-resistant isolates and atypical pathogens such as mycoplasma pneumoniae and chlamydia pneumoniae). thiamphenicol is present as glycinate hydrochloride (tg) and glycinate acetylcysteinate (tga) esters in the parenteral and aerosol dosage form. this multicenter, double-blind, randomized clinical trial aimed to evaluate the efficacy ... | 2002 | 12120883 |
| culturing chlamydophila pneumoniae. | 2002 | 12120889 | |
| influence of clarithromycin on early atherosclerotic lesions after chlamydia pneumoniae infection in a rabbit model. | chlamydia pneumoniae may play a role in atherogenesis and vascular diseases, and antibiotics may prove useful in these conditions. three groups of new zealand white rabbits (24 per group) were infected via the nasopharynx with c. pneumoniae on three separate occasions (2 weeks apart). group i was untreated and sacrificed at 12 weeks; group ii received clarithromycin at 20 mg/kg/day for 8 days, beginning 5 days after each inoculation (early treatment); and group iii received a similar dose of cla ... | 2002 | 12121899 |
| immunoblotting analysis of abdominal aortic aneurysms using antibodies against chlamydia pneumoniae recombinant momp. | antibodies against chlamydia pneumoniae have been associated with atherosclerosis and with expansion of abdominal aortic aneurysms (aaa). c. pneumoniae has been demonstrated in coronary arteries, aaa and the carotid arteries by use of polymerase chain reactions (pcr), immunohistochemical procedures and electron microscopy. however, the correlation between demonstrating c. pneumoniae dna or antigen in tissue from plaque material or aneurysms and the antibody titres in serum is controversial. the ... | 2002 | 12127853 |
| [association between cardiovascular disease and anti-chlamydia pneumoniae antibodies]. | to evaluate the association between cardiovascular disease (cvd) and antibodies against chlamydia in mexican population. | 2002 | 12132322 |
| the role of chlamydia trachomatis in prostatitis. | ascending chlamydial infections have been thought to be an infective cause of prostatitis for the last three decades. unfortunately, the definitive association between isolation of an infective agent and its prostatic origin is limited by various factors, although modern techniques of molecular biology for identification of the microorganisms are available. two major problems are: (1) diagnostic material passing the urethra may reflect only urethral contamination, (2) prostatic biopsy specimens ... | 2002 | 12135834 |
| [coinfection with chlamydia and mycoplasma. incidence in our environment]. | to investigate the presence mycoplasma pneumoniae and chlamydia pneumoniae and to determine their importance as the cause of community-acquired pneumonia in childhood. | 2002 | 12139864 |
| role of infection in atherosclerosis and coronary artery disease: a new therapeutic target? | there is growing evidence that inflammatory processes may be involved in the development of atherosclerosis and its complications. viral and bacterial pathogens have been implicated as possible causative factors in the pathogenesis of coronary artery disease and postangioplasty restenosis. antibiotic trials have been completed examining which treatment of infection can prevent the complications of coronary artery disease. in high-risk patients, the results of these most recent studies have not r ... | 2002 | 12144730 |
| detection and differentiation of chlamydiae by fluorescence in situ hybridization. | chlamydiae are important pathogens of humans and animals but diagnosis of chlamydial infections is still hampered by inadequate detection methods. fluorescence in situ hybridization (fish) using rrna-targeted oligonucleotide probes is widely used for the investigation of uncultured bacteria in complex microbial communities and has recently also been shown to be a valuable tool for the rapid detection of various bacterial pathogens in clinical specimens. here we report on the development and eval ... | 2002 | 12147510 |
| immunological basis of inflammation in dialysis. | several studies indicate that chronic inflammation is the major determinant of the 'dialysis syndrome' characterized by malnutrition, cachexia and vasculopathy and responsible for the high mortality and morbidity rate in dialysed patients. uraemia together with repeated contact with the dialytic devices are considered the most important factors eliciting the immune system response resulting in inflammation. dialysis may also contribute by means of bacterial contamination of dialysis fluids or ac ... | 2002 | 12147772 |
| atherosclerosis in dialysis patients: does chlamydia pneumoniae infection contribute to cardiovascular damage? | cardiovascular risk in the dialysis population is exceedingly high, and there is now convincing evidence that inflammation is strongly linked to atherosclerosis in this population. the source of inflammation in dialysis patients still remains undefined. bacterial contamination during the extracorporeal circulation and bioincompatibility explain only a very small part of the high prevalence of inflammation [as defined by raised c-reactive protein (crp)] in these patients. in the general populatio ... | 2002 | 12147773 |
| chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatment. | a study was undertaken to evaluate chlamydia pneumoniae chronic infection, other respiratory infections, and functional impairment in patients with chronic bronchitis (stage 1) and to examine chronic c pneumoniae infection, rate of acute exacerbations of chronic bronchitis, and rate of c pneumoniae eradication following antibiotic treatment (stage 2). | 2002 | 12149525 |
| clinical efficacy of new antibacterial therapies in at-risk populations. | infections of the lower respiratory tract, such as community-acquired pneumonia (cap) and acute bacterial exacerbations of chronic bronchitis (aecb), comprise the more serious respiratory tract infections (rtis), and are associated with considerable morbidity and mortality, particularly in groups such as the very young, the elderly and those with co-morbid illness. up to 80% of community-acquired rtis are caused by streptococcus pneumoniae, haemophilus influenzae or moraxella catarrhalis and are ... | 2002 | 12150492 |
| absence of chlamydia pneumoniae in surgical specimens of coronary and carotid arteries by polymerase chain reaction. | several recent articles indicate the renewed interest that chlamydia pneumoniae is associated with and contributes to arterial diseases. associations have been established for coronary arteries, carotid arteries and abdominal aortic aneurysms by serological studies, immunofluorescence and dna-specific testing. the purpose of this study was to determine the presence of c. pneumoniae in coronary artery plaques, carotid artery plaques and old vein grafts that were harvested at the time of surgery. | 2001 | 12160763 |
| antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, chlamydia pneumoniae and streptococcus group a. | we measured autoantibodies against nine different neuron-specific antigens and three cross-reactive peptides in the sera of autistic subjects and healthy controls by means of enzyme-linked immunosorbent assay (elisa) testing. the antigens were myelin basic protein (mbp), myelin-associated glycoprotein (mag), ganglioside (gm1), sulfatide (sulf), chondroitin sulfate (conso4), myelin oligodendrocyte glycoprotein (mog), alpha,beta-crystallin (alpha,beta-crys), neurofilament proteins (nafp), tubulin ... | 2002 | 12161033 |
| measuring genome divergence in bacteria: a case study using chlamydian data. | we have studied the relative contribution of inversions, transpositions, deletions, and nucleotide substitutions to the evolution of chlamydia trachomatis and chlamydia pneumoniae. the minimal number of rearrangement events required for converting the gene order structure of one genome into that of the other was estimated to 59 +/- 6 events, including 13% inversions, 38% short inversions, and 49% transpositions. in contrast to previous findings, no examples of horizontal gene transfer subsequent ... | 2002 | 12165840 |
| is chlamydia pneumoniae found in spinal fluid samples from multiple sclerosis patients? conflicting results. | cerebrospinal fluid samples from controls and patients with multiple sclerosis (ms) were split and sent to laboratories with different experiences for the detection of chlamydia pneumoniae by polymerase chain reaction. vanderbilt investigators identified c. pneumoniae in the majority of patients with ms and uncommonly in controls. laboratories at johns hopkins university, university of umeå, and the centers for disease control and prevention did not identify c. pneumoniae in any of the samples. ... | 2002 | 12166498 |
| detection of chlamydia pneumoniae by polymerase chain reaction-enzyme immunoassay in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls. | it has been suggested that chlamydia is an organism that may have the potential to cause inflammatory bowel disease (ibd) in susceptible individuals. chlamydia pneumoniae has emerged as an important human pathogen in the last decade. the objective of the present study was to investigate the frequency of the presence of c. pneumoniae dna in intestinal biopsies from patients with ibd and from non-ibd controls. | 2002 | 12167120 |
| microevolutionary genomics of bacteria. | the availability of multiple complete genome sequences from the same species can facilitate attempts to systematically address basic questions in genome evolution. we refer to such efforts as "microevolutionary genomics". we report the results of comparative analyses of complete intraspecific genome (and proteome) sequences from four bacterial species--chlamydophila pneumoniae, escherichia coli, helicobacter pylori and neisseria meningitidis. comparisons of average synonymous (k(s)) and nonsynon ... | 2002 | 12167363 |
| chlamydia pneumoniae pathogenesis. | 2002 | 12171291 | |
| comparison of two microimmunofluorescence tests for detecting antibodies to chlamydia pneumoniae. | two microimmunofluorescence (mif) tests were compared for detection of antibodies to chlamydia pneumoniae: the microimmunofluorescence of washington university and the microimmunofluorescence of chlamydia serofia. concordant positive results at the same dilution were observed for igg in 37.33% of sera tested and concordant negative results were found in 44%. variations of one fold dilution were observed in 36 sera. extensive variations (2-3 two-fold dilutions) in the numeric titer values were ob ... | 2002 | 12173771 |
| [antibodies seroprevalence for mycoplasma pneumoniae antigens in patients with bronchial asthma]. | microorganisms causing respiratory system infections, mainly viruses but also bacteria, among which there are atypical such as chlamydophila pneumoniae, play a role in etiopathogenesis of bronchial asthma. mycoplasma pneumoniae is suggested to take part in the initiation and the bronchial asthma exacerbation. the aim of the paper was to determine the frequency of occurrence of anti-mycoplasma pneumoniae antibodies in serum of patients suffering from bronchial asthma in comparison with the contro ... | 2002 | 12182000 |
| chlamydia pneumoniae and hyperlipidemia are co-risk factors for atherosclerosis: infection prior to induction of hyperlipidemia does not accelerate development of atherosclerotic lesions in c57bl/6j mice. | chlamydia pneumoniae has been shown to accelerate atherosclerotic lesion development in hyperlipidemic animals. this study showed that c. pneumoniae did not accelerate lesion development in mice if a high-fat/high-cholesterol diet was started after infection, indicating that c. pneumoniae is a co-risk factor with hyperlipidemia for cardiovascular disease. | 2002 | 12183595 |
| [chlamydia pneumoniae infections--diagnostic methods]. | gram-negative bacteria chlamydia pneumonia was found in 1989 to cause acute and chronic respiratory tract infections. this agent has been as well associated with other disease: atherogenesis and coronary heart disease. this study is aimed both at making an introduction to the issues related to c. pneumoniae diagnosis and presenting contemporary laboratory methods. given the limitations of traditional diagnostics methods, serodiagnosis (eia) and nucleic acids amplification (pcr, hybridisation) pr ... | 2002 | 12184026 |
| [chlamydia pneumoniae infection and multiple sclerosis]. | possible association of chlamydia pneumoniae and multiple sclerosis is the subject of recent interest. the findings concerning the isolation of the agent from csf and tissue from postmortem brain are controversial, similarly as absorption of oligoclonal bands in csf by this antigen. the hypothesis should be further studied to establish whether an association of ch. pneumoniae with ms exists or not. | 2002 | 12185805 |
| immune activation as effect modifier of atherogenesis in chronic infection. | although no study has proven that infections cause atherosclerotic disease, findings suggest that exposure to infections such as chlamydia pneumoniae, helicobacter pylori, and bacterial infections related to periodontal disease or smoking might influence the development of heart, carotid, and peripheral vascular disease. epidemiological data convincingly demonstrate risk for atherosclerotic disease associated with bacterial infection and endotoxemia; however, the independent contributions to dis ... | 2002 | 12187843 |
| could an infectious trigger explain the differential maternal response to the shared placental pathology of preeclampsia and normotensive intrauterine growth restriction? | preeclampsia/eclampsia remains an important cause of maternal and perinatal morbidity and mortality. its origins lie in a mismatch between fetoplacental demands and the ability of the uteroplacental arteries to supply those demands, a situation that also arises in normotensive intrauterine growth restriction (the fetal syndrome of preeclampsia in isolation). why is there this differential response to the same underlying pathology? this review summarises the evidence surrounding a potential trigg ... | 2002 | 12190839 |
| prevalence, rate of persistence and respiratory tract symptoms of chlamydia pneumoniae infection in 1211 kindergarten and school age children. | is a common cause of respiratory disease, but little is known about asymptomatic infection, duration of persistent respiratory tract infection and seasonal changes of prevalence in a normal large sample size pediatric population. | 2002 | 12192165 |
| [autoantibodies and anti-factor viii and chlamydia pneumoniae infection]. | we report the case of a 64-year-old man without hemorrhagic history experiencing epistaxis. the standard hemostasis assessment including prothrombin index, activated partial thromboplastin time (aptt) and platelet count found an isolated abnormal aptt (105 sec vs 33 sec). therefore, coagulation factors were explored. an acquired factor viii deficiency (5%) with anti-fviii antibody (4.5 bethesda unit.ml-1) was recognised. this anti-fviii antibody was related to a chlamydia pneumoniae pulmonary in ... | 2002 | 12192696 |
| multiple chlamydia pneumoniae antigens prime cd8+ tc1 responses that inhibit intracellular growth of this vacuolar pathogen. | cd8(+) t cells play an essential role in immunity to chlamydia pneumoniae (cpn). however, the target ags recognized by cpn-specific cd8(+) t cells have not been identified, and the mechanisms by which this t cell subset contributes to protection remain unknown. in this work we demonstrate that cpn infection primes a pathogen-specific cd8(+) t cell response in mice. eighteen h-2(b) binding peptides representing sequences from 12 cpn ags sensitized target cells for mhc class i-restricted lysis by ... | 2002 | 12193722 |
| macrolide treatment does not influence serum homocysteine in chlamydia pneumoniae-seropositive patients suffering from atherosclerosis. | 2002 | 12194961 | |
| proinflammatory cytokines, antibodies to chlamydia pneumoniae and age-associated diseases in danish centenarians: is there a link? | plasma levels of tumour necrosis factor (tnf)-alpha levels increase with age. high levels are associated with dementia and atherosclerosis in centenarians. chlamydia pneumoniae induces the production of proinflammatory cytokines and has been related to the pathogeneses of alzheimer's disease and cardiovascular diseases. the purpose of this study was to test the hypothesis that circulating levels of tnf-alpha represent a link between c. pneumoniae, high prevalences of dementia and cardiovascular ... | 2002 | 12195874 |
| [chlamydia pneumoniae and acute respiratory tract infections in breast-feeding infants: simultaneous mother-child serological study in niamey (niger)]. | the age and the origin of chlamydia pneumoniae primary infection in sahelian areas are unknown. to evaluate the prevalence of c. pneumoniae antibodies, the authors studied the serological status of c. pneumoniae-, c. psittaci- and c. trachomatis-specific antibodies of 50 mother-child couples using the microimmunofluorescence technique. children were 10 to 34 month-old (18,1 6,2, mean sd), breast-fed and hospitalized with acute respiratory tract infections in niamey (republic of niger). speci ... | 2002 | 12196294 |
| association of chlamydia pneumoniae with coronary artery disease and its progression is dependent on the modifying effect of mannose-binding lectin. | the possible association between coronary artery disease (cad) and chlamydia pneumoniae (c pneumoniae) infection is controversial. on the basis of the recent suggestion that mannose-binding lectin (mbl) variant alleles are related to an increased risk of severe atherosclerosis, and on the in vitro interaction of mbl with c pneumoniae, we asked whether mbl might contribute to cad in conjunction with c pneumoniae. | 2002 | 12196331 |
| [the role of infection and inflammation in the pathogenesis of atherosclerosis]. | pathogenesis of the atherosclerotic process is deemed as multifactorial. to the most important risk factors, besides certain family predisposition, there belongs hypercholesterolemia, arterial hypertension, obesity, diabetes mellitus, smoking and others. in the last years there are more and more data about the role of inflammation and infection in the whole development of atherosclerosis. the witness for this hypothesis is the findings of high parameters of inflammation in involved vessels as we ... | 2002 | 12197410 |
| chlamydia pneumoniae seropositivity and early carotid atherosclerosis in a suburban japanese population. | to evaluate the association between chlamydia pneumoniae (c. pneumoniae) infection and carotid atherosclerosis (ca), we investigated ca assessed by carotid b-mode ultrasound and known or suspected atherosclerotic risk factors including c. pneumoniae igg and iga antibodies in 2410 residents (mean age 54.5+/-13.6 years, 697 men) of a suburban japanese town. ca was found in 30.1% of men and in 14.0% of women, igg in 59.4% and in 51.4%, and iga in 36.9% and in 32.4%, respectively. in univariate anal ... | 2002 | 12204803 |
| comparative in vitro activity of garenoxacin against chlamydia spp. | the in vitro susceptibilities of 33 isolates of chlamydia trachomatis, chlamydia pneumoniae and chlamydia psittaci to a new quinolone drug, garenoxacin (bms-284756), in comparison with levofloxacin, ciprofloxacin, doxycycline, erythromycin and roxithromycin, were determined. garenoxacin was the most active of the quinolone drugs tested, with identical mic and mbc, which ranged from 0.007 to 0.03 mg/l. the mic and mbc of the other two quinolones tested, levofloxacin and ciprofloxacin, were also i ... | 2002 | 12205067 |
| [role of viral infections and chlamydia pneumoniae and mycoplasma pneumoniae infections in asthma in infants and young children. epidemiologic study of 118 children]. | wheezing associated with upper respiratory tract infections is common in children. using conventional techniques (viral culture and immunofluorescence) and molecular techniques (pcr), we studied the prevalence of viral, chlamydia pneumoniae (cp) and mycoplasma pneumoniae (mp) infections in 118 children hospitalised for acute asthma exacerbation. a virus was identified by conventional techniques in 40 of the 118 nasal swabs (34%), while pcr allowed identification of virus cp and mp in 80 samples ... | 2002 | 12205810 |
| [cardiovascular prevention: new biochemical plasmatic markers of risk]. | the primary prevention of acute coronary syndromes is an open question. the scientific progress has discovered new biochemical markers of cardiovascular disease risk that may be useful for primary prevention. they are plasmatic markers of inflammation (serum amyloid a, c-reactive protein, phospholipase a2) and of infection (seropositivity to chlamydia pneumoniae, cytomegalovirus). they are plasmatic markers of endothelial activation (adhesion molecules such as icam-1, vcam-1) immunological marke ... | 2002 | 12207197 |
| role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by chlamydia pneumoniae. | chlamydia pneumoniae stimulates potently maturation of and cytokine secretion by bone marrow-derived dendritic cells (bmddc). bmddc responses depend mainly on toll-like receptor (tlr)2 and to a minor extent on tlr4. we demonstrate here using c. pneumoniae in an infectious model with the replication-permissive epithelial cell line hep2 that hsp60 is produced in substantial amounts in chlamydial inclusions during infection. electron microscopy of chlamydial inclusions revealed that hsp60 was mainl ... | 2002 | 12207330 |
| chlamydia pneumoniae activates ikk/i kappa b-mediated signaling, which is inhibited by 4-hne and following primary exposure. | chlamydia pneumoniae may be involved in atherosclerosis by inducing inflammation as well as ldl oxidation. the transcription factor nf-kappa b is found in an active state in atherosclerotic lesions. this study examined the effect of c. pneumoniae exposure on the nf-kappa b system in human monocytic lineage cells. short exposure to c. pneumoniae as well as chlamydial heat shock protein 60 activated nf-kappa b, accompanied by increased cytokine production. incubation with c. pneumoniae-induced dep ... | 2002 | 12208473 |
| effect of treatment for chlamydia pneumoniae and helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: south thames trial of antibiotics in myocardial infarction and unstable angina (stamina). | infection with helicobacter pylori and chlamydia pneumoniae is associated with coronary heart disease. we conducted an intervention study using antibiotics against these bacteria in patients with acute coronary syndromes to determine whether antibiotics reduce inflammatory markers and adverse cardiac events. | 2002 | 12208796 |
| chlamydophila pneumoniae infection of human aortic endothelial cells induces the expression of fc gamma receptor ii (fcgammarii). | chronic endothelial infection is believed to be one of the factors able to cause endothelial cell damage and trigger the onset of human atherosclerosis. chlamydophila pneumoniae infects endothelial cells and has received special attention because of both epidemiological and experimental evidence supporting its role as a risk factor for atherosclerosis. it is also possible that otherwise independent risk factors for atherosclerosis may have synergistic effects. immune phenomena, such as the forma ... | 2002 | 12217337 |